Now I look like I feel inside.

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1 Actual RADIESSE Patient Age 49 Now I look like I feel inside.

2 Collagen and the natural aging process. An abundance of healthy collagen is what gives skin a smooth, supple, youthful appearance. As you age, natural collagen breaks down, resulting in skin laxity, wrinkles and loss of facial volume which can make your skin look and feel old. Youthful appearance: Optimal volume distribution A sign of the times: Increased volume shift Aging process The best way to refresh your appearance is by replenishing the volume your skin has lost. This diminishes wrinkles, resulting in a much more youthful look. RADIESSE Volumizing Filler is an ideal choice. In addition to providing immediate volume correction, it also stimulates production of your own natural collagen - something that no other filler does! 1 The result is immediate and lasts a year in many patients. 2, 3

3 Immediate results, increased collagen production. How it works: RADIesse Volumizing Filler immediately provides the lift needed to diminish signs of aging because of the incredible lifting capacity of the product that comprises calcium-based microspheres and gel. What makes RADIesse Volumizing Filler truly unique is its ability to act like a scaffold under the skin, providing structure and lift and stimulating your own natural collagen to grow. This natural collagen growth continues for several months, 1 which extends the initial effect of RADIesse Volumizing Filler. In many patients, correction lasts for a year or more, so choose RADIesse Volumizing Filler for long-lasting, natural, and youthful results. 2,3 The calcium-based microspheres suspended in gel works instantly, resulting in an immediate correction. After injection, the new collagen tissue is stimulated to produce naturally. 1 Over time, the gel is absorbed and the calcium-based microspheres are metabolized by the body, leaving behind your own, natural collagen. 1

4 Refresh key areas with RADIesse Volumizing Filler. Targeting the areas below with RADIESSE Volumizing Filler helps lead to a more youthful looking you. See examples on the next panel showing how RADIESSE Volumizing Filler refreshes the appearance of actual patients in these key areas. Cheeks Smile Lines Corners of the Mouth Marionette Lines Chin Wrinkle Pre-Jowl Fold Hands *Individual results may vary.

5 Smile Lines Marionette Lines and Corners of the Mouth Pre-Jowl and Marionette Lines Nasolabial Folds and Chin Wrinkle Hand *Individual results may vary.

6 Real patients. Real results. Real satisfaction. It doesn t change the way I look, it just enhances it. Zetta. Age 51. I love the results, my husband loves the results. He s complimenting me every day! Damaris. Age 52. Patient featured to the right. It s an invisible, beautiful result. I love it. Blaine. Age 49. *Individual results may vary.

7 The RADIesse Difference. The only filler to both immediately replenish lost volume and stimulate the production of your own natural collagen. 1 Clinically proven to last a year or more in many patients. 2,3 With just one treatment of Radiesse Volumizing Filler wrinkles and folds may disappear.* Immediately. Subtly. And because Radiesse Volumizing Filler naturally stimulates your body s own collagen, your skin looks even better over time. 1 Begin your journey towards a better looking you today! Ask your healthcare provider what RADIesse Volumizing Filler can do for you. To learn more, visit *When wrinkle or fold is treated to full correction.

8 Intelligent solutions from Merz Aesthetics. Merz Aesthetics builds upon our proud 100-year heritage in healthcare. Renowned for exceptional quality and outstanding results, the Merz Aesthetics product portfolio is trusted by both patients and healthcare providers. Our expanding portfolio is geared toward helping patients around the world look as vibrant as they feel. Learn more at Radiesse.ca. Important RADIESSE VOLUMIZING FILLER Treatment ConSIDErations RADIESSE Volumizing Filler is indicated for subdermal implantation for the correction of moderate to severe facial wrinkles and folds, such as nasolabial folds and the rejuvenation of the hand. After injection, patients may experience redness, bruising, swelling or other local side effects. Most side effects of treatment resolve within a few days. More rare side effects may include swelling that lasts longer, unevenness or firmness in the area injected, and as with any injection, there may be a risk of infection. Please see instructions for use for full list of warnings and precautions. 1. Berlin A, Hussain M, Goldberg D. (2008) Calcium Hydroxlapatite Filler (RADIESSE ) for Facial Rejuvenation: A Histologic and Immonohistochemical Analysis. Dermatologic Surgery, Volume 34, S64-S Moers-Carpi M, Vogt S. (2007) A Multicenter, Randomized Trial Comparing Calcium Hydroxylapatite to Two Hyaluronic Acids for Treatment of Nasolabial Folds. Dermatologic Surgery, 33(S52), S144-S Bass LS, Smith S, Busso M, McClaren M. (2010) Calcium Hydroxylapatite (RADIESSE) for Treatment of Nasolabial Folds: Long-Term Safety and Efficacy Results. Aesthetic Surgery J, 30 (2): Merz Pharma Canada. All rights reserved. Merz Aesthetics and the Merz Aesthetics logo are trademarks of Merz Pharma GmbH & Co. KGaA. RADIESSE is a registered trademark of Merz North America, Inc.

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