Idiopathic inflammatory muscle diseases. Dr. Paul Etau Ekwom MBChB, MMED Kenyatta National Hospital, Nairobi-Kenya
|
|
- Luke Chapman
- 5 years ago
- Views:
Transcription
1 Idiopathic inflammatory muscle diseases. Dr. Paul Etau Ekwom MBChB, MMED Kenyatta National Hospital, Nairobi-Kenya
2 I.W, 28 YRS, FEMALE SHOP STEWARD Referred to KNH on 16/06/09 from Thika Nursing Home Weakness for 3/12 Difficulty swallowing for 3/52
3 Progressive weakness :neck muscles then limb girdle. Weakness had no diurnal pattern. No reported muscle pain. Progressive dysphagia, no odynophagia Associated fatigue. No diplopia, ptosis or sphincter involvement
4 h/o weight loss H/o arthralgia but no other no other historical features to suggest connective tissue disease No history of pregnancy losses or any clotting. No symptoms of thyroidal illness No h/o drug use reported, no alcohol use. No known exposure to any toxins or heavy metals. No vaginal bleeding, breast lump, altered bowel habits, cough reported
5 Seen initially by ENT team, came with barium meal that showed? Prox. Esophageal mass..panendoscopy and biopsy results were negative.
6 Examination Young female, ill looking with a nasogastric tube in place. Normal hair distribution and character, no oral ulcers, no malar rash, no cutaneous features of dermatomyositis or scleroderma noted. Limb girdle and neck weakness with decreased muscle power; power grade 2. normal deep tendon reflexes and tone. Distal muscle groups power grade 4-5
7 Laboratory tests TBC: Leucocytosis; WBC 15.1, Hb 14.7, plt 602 ESR 45 mm/hr. CPK: normal levels LDH: elevated 674 U/L, AST 60 u/l, ALT 45 u/l RBS: 4.6 mmol/l htsh: 0.48 uiu/ml (0.25-5) Urinalysis : normal
8 Creatinine 68 umol/l; egfr : 89.5 mls/min ANA: positive HIV 1 and 2 ELISA: Negative HBsAg: Negative. HCV serology: negative. Blood cultures: negative Anti-DSDNA: positive. RF: positive Tensilon test : negative
9 Plain radiograph chest: normal. ECG/echo: normal EMG: proximal upper and lower limb muscles showed myopathic potentials. Nerve conduction studies were normal. Histology: myositis; bundles of skeletal muscles with inflammation and degenerative changes. Heavy infiltration of lymphocytes with myolysis.
10 By Bohan Peter criteria (1975) fulfils diagnosis of polymyositis. Bohan and peter criteria Symmetric proximal muscle weakness Elevation of muscle enzymes: CK,LDH,AST, ALT Abnormal EMG with myopathic potentials, fibrillations Muscle biopsy with features of infiltration with lymphocytes, necrosis and regeneration. Typical skin rash for dermatomyositis ; for diagnosis of dermatomyositis. In view of young female, arthralgia and positive ANA, dsdna,? SLE Overlap syndrome
11 Differential diagnosis of I.I.M Viral myositis: Coxsackie virus, echo, influenza viruses, HIV, Hepatitis virus Bacterial and parasitic infections: Pyomyositis, Trichinella spiralis, Trypanosomiasis. Alcoholic myopathy Diabetes myopathy DRUGS :Statins, fibrates,zidovudine, HCQ, cimetidine,colchicine, glucocorticoids. Muscular dystrophies Thyroidal illness Vasculitis Myasthenia gravis. Neuropathies Granulomatous myositis: sarcoidosis
12 Treatment Prednisolone 60mg/day and taper. Methotrexate started at 7.5 mg/week Folate Omeprazole Calcium/vitamin D NGT feeding..currently removed, able to swallow. Physiotherapy: exercises.
13 I.I.M Rare disorders Combined incidence of 2-7 per million population. Three main subgroups, dermatomyositis (DM), polymyositis (PM) and inclusion body myositis (IBM) Polymyositis and dermatomyositis are commoner in Females than males; 3:1. Inclusion body myositis is commoner in men. Peak age (Though PM,DM may start at any age) They each may present in isolation or with a connective tissue disorder ;SLE, RA, Sjögren's syndrome, polyarteritis nodosa (PAN), scleroderma and mixed connective tissue disease.
14 Causes PM/DM are autoimmune diseases with association with with genetic HLA class II alleles. IBM is thought to be a degenerative disorder due to presence of tau proteins and amyloid. Association with viral infections. Association with malignancy in DM; haematological, lung, ovary, breast, colon. In polymyositis, association with malignancy is uncertain.
15 Clinical features Muscle weakness and fatigue. Cutaneous features : Gottron s changes, heliotrope rash, periungal capillary changes, mechanic hands, ulcers, livedo reticularis, subcutaneous calcinosis. Raynauds phenomenon Dyspnoea. Arthralgia and non-erosive arthritis. Dysphagia, reflux. Cardiovascular: congestive heart failure, conduction abnormalities, coronary artery disease. Amyopathic dermatomyositis.
16 Diagnosis Muscle enzymes: CPK, LDH, AST,ALT, ALDOLASE. Myoglobin EMG Muscle biopsy. Imaging: MRI-T1,2 and STIR sequences. Autoantibodies: ANA- in 60-70%. Anti aminoacyl t RNA synthetase ( Anti Jo-1) Anti Mi-2, anti-signal recognition particle (anti-srp). Anti in dermatomyositis associated with cancer Anti CADM 40 in amyopathic dermatomyositis. Anti-SUMO 1 antibodies in DM with ILD
17 Other tests ECG, ECHO Pulmonary function tests CT scan chest. Tests to r/o differentials: viral serologies, HIV tests, Blood sugar, thyroid profile
18 Screening for malignancies History and examination. DRE, breast and pelvic examination. Xray chest Mammogram. FOBT PNS examination Abdomen and pelvic imaging.
19 Treatment options Glucocorticoids Immunosuppressive therapy: Methotrexate Azathioprine MTX and AZA Cyclosporine Cyclophosphamide Mycophenolate mofetil Ivig ATG
20 Progress Muscle strength CPK ESR, CRP
21 asante any comments?
Inflammatory Myopathies 4 th year MBBS. Marwan Adwan MBChB, MSc, MRCPI, MRCP(rheum) Consultant Rheumatologist
Inflammatory Myopathies 4 th year MBBS Marwan Adwan MBChB, MSc, MRCPI, MRCP(rheum) Consultant Rheumatologist Case A 64 woman presents with erythematous itchy rash over back of hands & forehead. For 1 month
More informationAutoantibodies in the Idiopathic Inflammatory Myopathies
Autoantibodies in the Idiopathic Inflammatory Myopathies Steven R. Ytterberg, M.D. Division of Rheumatology Mayo Clinic Rochester, MN The Myositis Association Annual Conference St. Louis, MO Sept. 25,
More information2/23/18. Disclosures. Rheumatic Diseases of Childhood. Making Room for Rheumatology. I have nothing to disclose. James J.
Making Room for Rheumatology James J. Nocton, MD Disclosures I have nothing to disclose Rheumatic Diseases of Childhood Juvenile Idiopathic Arthritis (JIA) Systemic Lupus Erythematosus (SLE) Juvenile Dermatomyositis
More informationIDIOPATHIC INFLAMMATORY MYOPATHIES AND RELATED DISORDERS. Franclo Henning Division of Neurology Tygerberg Hospital
IDIOPATHIC INFLAMMATORY MYOPATHIES AND RELATED DISORDERS Franclo Henning Division of Neurology Tygerberg Hospital Classification systems Clinical (Bohan and Peter) Clinico-pathological (Dalakas & others)
More informationPOLYMYOSITIS (PM) DERMATOMYOSITIS (DM) Body myositis Eosinophilic myositis Giant cell myositis Focal / localised myositis Myopathies caused by
POLYMYOSITIS (PM) DERMATOMYOSITIS (DM) Body myositis Eosinophilic myositis Giant cell myositis Focal / localised myositis Myopathies caused by infections, drugs, toxins Definition Epidemiology Pathogenesis
More informationL. Nandini Moorthy, MD MS 2012
L. Nandini Moorthy, MD MS 2012 L Nandini Moorthy, MD MS 09 17 yo Ashkenazi male with proximal muscle pain and weakness, mild malar erythema and erythema over knees and dorsal aspect of PIPs Mild tenderness
More informationThe many faces of myositis. Marianne de Visser Academic Medical Centre Dept of Neurology Amsterdam The Netherlands
The many faces of myositis Marianne de Visser Academic Medical Centre Dept of Neurology Amsterdam The Netherlands Outline of the presentation Classification Diagnosis Therapy Prognosis Diagnostic criteria
More informationRheumatology E-learning. University of Szeged Department of Rheumatology and Immunology
Rheumatology E-learning University of Szeged Department of Rheumatology and Immunology Introduction Idiopathic inflammatory myopathies (IIM) are a group of systemic diseases characterized by an immune
More informationArthritis Superspeciality Center, Hubli, Karnataka and 2 Department of Rheumatology, SDM Medical College, Dharwad, Karnataka, India.
JOURNAL OF CASE REPORTS 2015;5(1):147-151 A Rare Case of Juvenile Dermatomyositis Vikram Haridas 1,2, Kiran Haridas 1 1,2 Arthritis Superspeciality Center, Hubli, Karnataka and 2 Department of Rheumatology,
More informationMyositis and Your Lungs
Myositis and Your Lungs 2013 TMA Annual Patient Meeting Louisville, Kentucky Chester V. Oddis, MD University of Pittsburgh Director, Myositis Center Myositis Heterogeneous group of autoimmune syndromes
More informationUndifferentiated Connective Tissue Disease and Overlap Syndromes. Mark S. Box, MD
Undifferentiated Connective Tissue Disease and Overlap Syndromes Mark S. Box, MD Overlap Syndromes As many as 25% of patients with rheumatic diseases with systemic symptoms cannot be definitely diagnosed
More information4/16/2018. Demystifying weakness: how to approach refractory myositis. Objectives. Disclosures. Off-label uses for medications will be discussed
Demystifying weakness: how to approach refractory myositis Jemima Albayda, MD Assistant Professor Johns Hopkins Myositis center Disclosures Off-label uses for medications will be discussed Objectives To
More informationHUNGARIAN MYOSITIS COHORT
CLINICAL ADVANCES OF ANTI- TIF1Γ AUTOANTIBODY IN A HUNGARIAN MYOSITIS COHORT Melinda Nagy-Vincze 1, Zoltán Griger 1, Levente Bodoki 1, Zsuzsa Szankai 1, Zoe E. Betteridge 2, Katalin Dankó 1 1 University
More informationDermatomyositis Advice from Experts: Improving Your Medical Dermatology Diagnostic and Management Skills Jeffrey P. Callen, MD Professor of Medicine
Dermatomyositis Advice from Experts: Improving Your Medical Dermatology Diagnostic and Management Skills Jeffrey P. Callen, MD Professor of Medicine (Dermatology) University of Louisville Learning Objectives
More informationBudsakorn Darawankul, MD. Maharat Nakhon Ratchasima Hospital
Budsakorn Darawankul, MD. Maharat Nakhon Ratchasima Hospital Outline What is ANA? How to detect ANA? Clinical application Common autoantibody in ANA diseases Outline What is ANA? How to detect ANA? Clinical
More informationDiscovery, Understanding, and Progress in Myositis
Discovery, Understanding, and Progress in Myositis Steven Ytterberg, M.D. TMA Annual Patient Conference New Orleans, LA Sept. 2, 2016 Disclosures Financial: Dynavax Corp. Pfizer Mallinckrodt American Board
More informationMyositis 101. Steven R. Ytterberg, M.D. Division of Rheumatology Mayo Clinic, Rochester, MN
Myositis 101 Steven R. Ytterberg, M.D. Rheumatology Mayo Clinic, Rochester, MN Myositis Association Annual Conference Louisville, KY Sept. 6 & 7, 2018 Disclosures Consulting: Dynavax Pfizer Off-label use:
More informationThis month, we are very pleased to introduce some new tests for Scleroderma as well as some test changes to our existing scleroderma tests/panels.
February 20, 2017 Client Letter Test Update February 2017 Dear Colleague: This month, we are very pleased to introduce some new tests for Scleroderma as well as some test changes to our existing scleroderma
More informationWhat your autoantibodies tell us about your disease. Mark Gourley, MD
What your autoantibodies tell us about your disease Mark Gourley, MD The Importance of the Immune System Defends us against foreign invaders Self (cancer) and Nonself (virus, bacteria, etc.) But, if the
More informationWhat are Autoantibodies and how do they work in Myositis?
What are Autoantibodies and how do they work in Myositis? Neil McHugh, University of Bath and Royal National Hospital for Rheumatic Diseases Orlando September 2015 Royal National Hospital for Rheumatic
More informationCase Report Repository Corticotropin Injection for Treatment of Idiopathic Inflammatory Myopathies
Case Reports in Rheumatology Volume 2016, Article ID 9068061, 4 pages http://dx.doi.org/10.1155/2016/9068061 Case Report Repository Corticotropin Injection for Treatment of Idiopathic Inflammatory Myopathies
More informationMYOSITIS. A physician s guide to the
MYOSITIS A physician s guide to the TABLE OF CONTENTS Myositis basics... 1 contents... 3 Causes... 7... 11 Affected populations... 15 Diagnosis... 17... 25... 31 PHYSICIAN S GUIDE TO MYOSITIS matory
More informationPAEDIATRIC VASCULITIS
PAEDIATRIC VASCULITIS Lawrence Owino Okong o, Mmed (UoN); Mphil. (UCT). Lecturer, Department of Paediatrics and Child Health, University of Nairobi. Paediatrician/ Rheumatologist. OUTLINE Introduction
More informationDR.JANANI RAVI DR.GNANABALAN S UNIT DR.MEHTA CHILDREN HOSPITAL
DR.JANANI RAVI DR.GNANABALAN S UNIT DR.MEHTA CHILDREN HOSPITAL 1 ½ year old girl c/o *Prolonged fever 20 days *Puffiness of face and legs 20 days *Rash in the lower limbs 20 days Child was suspected to
More informationJeopardy. What s the rash? $100 $100 $100 $100 $100 $200 $200 $200 $200 $200 $300 $300 $300 $300 $300 $400 $400 $400 $400 $400
Jeopardy Antibodies & more antibodies Aching joints What s the rash? Potpourri Image Challenge $100 $100 $100 $100 $100 $200 $200 $200 $200 $200 $300 $300 $300 $300 $300 $400 $400 $400 $400 $400 $500 $500
More informationRHEUMATOLOGY OVERVIEW. Carmelita J. Colbert, MD Assistant Professor of Medicine Division of Rheumatology Loyola University Medical Center
RHEUMATOLOGY OVERVIEW Carmelita J. Colbert, MD Assistant Professor of Medicine Division of Rheumatology Loyola University Medical Center What is Rheumatology? Medical science devoted to the rheumatic diseases
More informationJUVENILE DERMATOMYOSITIS
JUVENILE DERMATOMYOSITIS - how to diagnose, how to treat? Miloš Nikolić, MD, PhD Professor and Chairman Department of Dermatology, Division of Pediatric Dermatology University of Belgrade, School of Medicine,
More informationIdiopathic inflammatory myopathies excluding inclusion body myositis
Idiopathic inflammatory myopathies excluding inclusion body myositis Marianne de Visser, Dept. of Neurology, Academic Medical Centre, Amsterdam, The Netherlands The idiopathic inflammatory myopathies (IIMs),
More informationIs it Autoimmune or NOT! Presented to AONP! October 2015!
Is it Autoimmune or NOT! Presented to AONP! October 2015! Four main jobs of immune system Detects Contains and eliminates Self regulates Protects Innate Immune System! Epithelial cells, phagocytic cells
More informationIdiopathic inflammatory myopathies
Myositis and cancer Idiopathic inflammatory myopathies Primary idiopathic polymyositis Primary idiopathic dermatomyositis Juvenile poly/dermatomyositis Myositis associated with another CTD Myositis associated
More informationMuscle Pathology Surgical Pathology Unknown Conference. November, 2008 Philip Boyer, M.D., Ph.D.
Muscle Pathology Surgical Pathology Unknown Conference November, 2008 Philip Boyer, M.D., Ph.D. Etiologic Approach to Differential Diagnosis Symptoms / Signs / Imaging / Biopsy / CSF Analysis Normal Abnormal
More informationAutoantibodies in Idiopathic Inflammatory Myopathies. Vidya Limaye Rheumatology Department Royal Adelaide Hospital
Autoantibodies in Idiopathic Inflammatory Myopathies Vidya Limaye Rheumatology Department Royal Adelaide Hospital Idiopathic Inflammatory Myopathies (IIM) Heterogeneous group of systemic autoimmune syndromes
More informationAutoantibodies andprognosis. Jiří Vencovský Institute of Rheumatology, Prague, Czech Republic
Autoantibodies andprognosis Jiří Vencovský Institute of Rheumatology, Prague, Czech Republic HeterogeneityofIIMs Diagnosis Polymyositis Dermatomyositis IBM Necrotising myopathy Paraneoplastic Amyopathic
More informationEvolving Uses of IVIG in myositis
Evolving Uses of IVIG in myositis Rossitza I. Chichkova, MD, MS Associate Professor Depts of Neurology and Internal Medicine University of South Florida, Tampa, FL Immune Function In Normal State: Protects
More informationEssential Rheumatology. Dr Ellen Bruce Consultant Rheumatologist CMFT
Essential Rheumatology Dr Ellen Bruce Consultant Rheumatologist CMFT Saving the best for last! Apparently people recall best the first and last thing they re told. Far too difficult to include everything.
More informationClinical Laboratory. 14:42:00 SSA-52 (Ro52) (ENA) Antibody, IgG 1 AU/mL [0-40] Oct-18
Clinical Laboratory Procedure Result Units Ref Interval Accession Collected Received Rheumatoid Factor
More informationObjectives. Non-Traumatic Muscle Pathologies. Abnormal Muscle Signal Intensity. Inflammatory Myositis. Polymyostis / Dermatomyositis.
Non-Traumatic Muscle Pathologies Ali Naraghi Division of Musculoskeletal Radiology Joint Department of Medical Imaging University of Toronto Objectives Define the range of non-traumatic pathologies affecting
More informationDisclosures. Rheumatological Approaches to Differential Diagnosis, Physical Examination, and Interpretation of Studies. None
Rheumatological Approaches to Differential Diagnosis, Physical Examination, and Interpretation of Studies Sarah Goglin MD Assistant Professor of Medicine Division of Rheumatology Disclosures None 1 [footer
More informationComplex repetitive discharge on electromyography as a risk factor for malignancy in idiopathic inflammatory myopathy
ORIGINAL ARTICLE Korean J Intern Med 2014;29:814-821 Complex repetitive discharge on electromyography as a risk factor for malignancy in idiopathic inflammatory myopathy Na Ri Kim 1, Eon Jeong Nam 1, Jong
More informationPhysiotherapy in Juvenile Dermatomyositis
Journal of Research and Practice on the Musculoskeletal System JOURNAL OF RESEARCH AND PRACTICE Review Article Physiotherapy in Juvenile Dermatomyositis Theodora Polychronopoulou Physiotherapist, Athens,
More informationNovel Classification of Idiopathic Inflammatory Myopathies Based on Overlap Syndrome Features and Autoantibodies
Novel Classification of Idiopathic Inflammatory Myopathies Based on Overlap Syndrome Features and Autoantibodies Analysis of 100 French Canadian Patients Yves Troyanov, MD, Ira N. Targoff, MD, Jean-Luc
More informationAcute Emergencies in Rheumatology
Acute Emergencies in Rheumatology Clare Higgens Northwick Park hospital and St George s Hospital London Acute Rheumatological Emergencies The Acute Hot joint Inflammatory back pain.. Systemic lupus erythematosus(sle)
More informationClinical Laboratory. [None
Clinical Laboratory Procedure Result Units Ref Interval Accession Collected Received Double-Stranded DNA (dsdna) Ab IgG ELISA Detected * [None 18-289-900151 Detected] Double-Stranded DNA (dsdna) Ab IgG
More informationSCLERODERMA SPECTRUM DISEASE
SCLERODERMA SPECTRUM DISEASE Mohammed A. Omair MBBS, SF Rheum Consultant Rheumatologist Assistant Professor King Saud University President of the Charitable Association for Rheumatic Diseases Agenda Background
More informationSTUDIES ON INTERLEUKIN-1 IN IDIOPATHIC INFLAMMATORY MYOPATHIES
From the Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden STUDIES ON INTERLEUKIN-1 IN IDIOPATHIC INFLAMMATORY MYOPATHIES Christina Dorph Stockholm 2009 All previously
More informationTest Name Results Units Bio. Ref. Interval
LL - LL-ROHINI (NATIONAL REFERENCE 135091593 Age 25 Years Gender Male 30/8/2017 91600AM 30/8/2017 93946AM 31/8/2017 84826AM Ref By Final COLLAGEN DISEASES ANTIBODY ANEL ANTI NUCLEAR ANTIBODY / FACTOR (ANA/ANF),
More information9/13/2015. Nothing to disclose
Jared Bozeman Kathleen Luskin MD Bipin Thapa MD Medical College of Wisconsin Milwaukee, Wisconsin Nothing to disclose 24 Year old previously healthy woman presenting from OSH Fatigue Weakness Neck swelling
More informationDisorders of Muscle. Disorders of Muscle. Muscle Groups Involved in Myopathy. Needle Examination of EMG. History. Muscle Biopsy
Disorders of Muscle Disorders of Muscle Zakia Bell, M.D. Associate Professor of Neurology and Physical Medicine & Rehabilitation Virginia Commonwealth University Cardinal symptom of diseases of the muscle
More informationAUTOIMMUNE DISORDERS IN THE ACUTE SETTING
AUTOIMMUNE DISORDERS IN THE ACUTE SETTING Diagnosis and Treatment Goals Aimee Borazanci, MD BNI Neuroimmunology Objectives Give an update on the causes for admission, clinical features, and outcomes of
More informationClinical significance of serum surfactant protein D (SP-D) in patients with polymyositisudermatomyositis: correlation with interstitial lung disease
Rheumatology 2002;41:1268 1272 Clinical significance of serum surfactant protein D (SP-D) in patients with polymyositisudermatomyositis: correlation with interstitial lung disease H. Ihn, Y. Asano, M.
More informationCHECK LIST FORM-MONTH 27 (Please note Month 27 is from enrolment not randomisation)
CHECK LIST FORM-MONTH 27 (Please note Month 27 is from enrolment not randomisation) Participant Initials: Date of Birth: Were the following forms completed for this visit? Follow Up Form Done t Done BVASWG
More informationSignificance of antibody testing in idiopathic inflammatory myopathies
2/0/20 Significance of antibody testing in idiopathic inflammatory myopathies Jiří Vencovský Institute of Rheumatology, Prague Diagnosis Polymyositis Juvenile DM (JPM) Paraneoplastic Myositis in overlap
More informationCase 1: History of J.H. Outside Evaluation. Outside Labs. Question #1
Case 1: History of J.H. 64 yo man seen at UCSF 6-256 25-07. 9 months ago onset progressive weakness of arms and legs, with muscle atrophy in arms. 4 months ago red scaly rash on face, back of hands and
More informationSerologic Markers CONVENTIONAL ANTIBODIES ANTIBODIES UNCONVENTIONAL. AIH Type I
Autoimmune Hepatitis By Thomas Frazier Objective What we need to know about AIH Diagnosis Treatment Difficulties in both Liver transplantation concerns AASLD Guidelines: Hepatology. 2010 Jun;51(6):2193-213.
More informationClinical Laboratory. 14:41:00 Complement Component 3 50 mg/dl Oct-18
Clinical Laboratory Procedure Result Units Ref Interval Accession Collected Received Thyroid Peroxidase (TPO) Antibody 5.0 IU/mL [0.0-9.0] 18-289-900139 16-Oct-18 Complement Component 3 50 mg/dl 18-289-900139
More informationDiagnostic Tests in Rheumatic Disease: What s Old, What s New & What s Useful? COPYRIGHT
Diagnostic Tests in Rheumatic Disease: What s Old, What s New & What s Useful? Robert H. Shmerling, M.D. Beth Israel Deaconess Medical Center Boston, MA Diagnostic Tests in Rheumatic Disease: What's Old,
More informationMyasthenia Gravis. Mike Gilchrist 10/30/06
Myasthenia Gravis Mike Gilchrist 10/30/06 Overview Background Pathogenesis Clinical Manifestations Diagnosis Treatment Associated Conditions Background Severe muscle disease Most common disorder of neuromuscular
More informationMyosites du sujet âgé
Myosites du sujet âgé Olivier Benveniste Département de Médecine Interne Centre de Référence Maladies Neuro-Musculaires Equipe Muscle Inflammatoire U974 Groupe Hospitalier Pitié-Salpêtrière Myositis classification
More informationLUPUS CAN DO EVERYTHING, BUT NOT EVERYTHING IS LUPUS LUPUS 101 SLE SUBSETS AUTOIMMUNE DISEASE 11/4/2013 HOWARD HAUPTMAN, MD IDIOPATHIC DISCOID LUPUS
LUPUS 101 LUPUS CAN DO EVERYTHING, BUT NOT EVERYTHING IS LUPUS HOWARD HAUPTMAN, MD IDIOPATHIC DISCOID LUPUS SLE SUBSETS SUBACUTE CUTANEOUS LUPUS DRUG INDUCED LUPUS NEONATAL LUPUS LATE ONSET LUPUS ANTI-PHOSPHOLIPID
More informationSerum levels of soluble ST2 and interleukin-33 in patients with dermatomyositis and polymyositis
Serum levels of soluble ST2 and interleukin-33 in patients with dermatomyositis and polymyositis L. Yuan 1, L. Yao 2, L. Zhao 1, L. Xia 1, H. Shen 1, J. Lu 1 1 Department of Rheumatology, First Affiliated
More informationThe idiopathic inflammatory myopathies
REVIEW Idiopathic Inflammatory Myopathies: Current Trends in Pathogenesis, Clinical Features, and Up-to-Date Treatment Recommendations Floranne C. Ernste, MD, and Ann M. Reed, MD Abstract Recently, there
More informationClinical Commissioning Policy Proposition:
Clinical Commissioning Policy Proposition: Rituximab for the treatment of dermatomyositis and polymyositis (Adults) Reference: NHS England A13X05/01 Information Reader Box (IRB) to be inserted on inside
More informationImmune tolerance, autoimmune diseases
Immune tolerance, autoimmune diseases Immune tolerance Central: negative selection during thymic education deletion of autoreactive B-lymphocytes in bone marrow Positive selection in the thymus Negative
More informationSCLERODERMA OVERLAP SYNDROME: A CASE REPORT Diwakar K. Singh 1, Nataraju H. V 2
SCLERODERMA OVERLAP SYNDROME: A Diwakar K. Singh 1, Nataraju H. V 2 HOW TO CITE THIS ARTICLE: Diwakar K. Singh, Nataraju H. V. Scleroderma Overlap Syndrome: A Case Report. Journal of Evolution of Medical
More informationClinical features of seven Japanese patients with anti-pl- antibody frequent positivity for anti-cyclic citrullinated peptide antibody
Cace report Clinical features of seven Japanese patients with anti-pl- antibody frequent positivity for anti-cyclic citrullinated peptide antibody Yoichiro Akiyama 1, Takao Nagashima 1, Masahiro Iwamoto
More informationMyositis and Autoimmune ILD
Myositis and Autoimmune ILD 2018 AURA Annual Meeting Sedona, Arizona June 2, 2018 Chester V. Oddis, MD Director, Myositis Center University of Pittsburgh Disclosures Genentech: Clinical trial support Idera:
More informationComplete Resolution of Dermatomyositis with Refractory Cutaneous Vasculitis by Intravenous Cyclophosphamide Pulse Therapy
CASE REPORT Complete Resolution of Dermatomyositis with Refractory Cutaneous Vasculitis by Intravenous Cyclophosphamide Pulse Therapy Shizuyo Tsujimura, Kazuyoshi Saito and Yoshiya Tanaka Abstract Cutaneous
More informationPedsCases Podcast Scripts
Pedss Podcast Scripts This is a text version of a podcast from Pedscases.com on Juvenile Dermatomyositis. These podcasts are designed to give medical students an overview of key topics in pediatrics. The
More informationmyopathy and interstitial lung dise
NAOSITE: Nagasaki University's Ac Title Author(s) Citation A case of primary Sjögren's syndrom myopathy and interstitial lung dise Koga, Tomohiro; Kouhisa, Yukiko; Na Akinari; Motomura, Masakatsu; Kawak
More informationDisclosures. Clinical Approach: Evaluating CTD-ILD for the pulmonologist. ILD in CTD. connective tissue disease or collagen vascular disease
Disclosures Clinical Approach: Evaluating CTD-ILD for the pulmonologist Industry relationships: Actelion, atyr Pharma, Boehringer-Ingelheim, Genentech- Roche, Gilead Aryeh Fischer, MD Associate Professor
More informationDevelopment of SLE among Possible SLE Patients Seen in Consultation: Long-Term Follow-Up. Disclosures. Background. Evidence-Based Medicine.
Development of SLE among Patients Seen in Consultation: Long-Term Follow-Up Abstract # 1699 May Al Daabil, MD Bonnie L. Bermas, MD Alexander Fine Hsun Tsao Patricia Ho Joseph F. Merola, MD Peter H. Schur,
More informationMyasthenia gravis. David Hilton-Jones Oxford Neuromuscular Centre
Myasthenia gravis David Hilton-Jones Oxford Neuromuscular Centre SWIM, Taunton, 2018 Myasthenia gravis Autoimmune disease Nature of Role of thymus Myasthenia gravis Autoimmune disease Nature of Role of
More informationA CRP B FBC C LFT D blood culture E uric acid
1 A 39 year old lady with rheumatoid arthritis is admitted to hospital with a hot, swollen and painful right knee. Which is the most important blood test? A CRP B FBC C LFT D blood culture E uric acid
More informationACR 2017 SAN DIEGO HIGHLIGHTS - INFLAMMATORY MYOPATHIES. Nikolaos Marketos Rheumatologist Volos,
ACR 2017 SAN DIEGO HIGHLIGHTS - INFLAMMATORY MYOPATHIES Nikolaos Marketos Rheumatologist Volos, 1-6-2018 No disclosures Epidemiology PM & DM Peak 5 15 yrs & 30-50 yrs : = 2-3 : 1 IBM > 50yrs : = 1 : 3
More informationDocSpot what patients want to know
DocSpot what patients want to know Professor Chris Denton Royal Free Hospital London, UK Madrid, February 2012 Copyright 2011 Raynaud's & Scleroderma Association. Charity Reg. No. 326306 DocSpot Live!
More informationThe Johns Hopkins Hospital
The Johns Hopkins Hospital 19901006 2016/03/21-04/20 (rheumatology) (emergecny medicine) (rheumatology consult team) attending Dr. Haque, R2 Dr. Michailidou, fellow Dr. Adler "She is a so interesting case.
More informationLiving with Lupus: An Insider s Perspective
Living with Lupus: An Insider s Perspective Pamela Thorpe, MD, FACP Lupus Foundation of America, Inc. Philadelphia Tri-State Chapter Volunteer May 2014 My Own Story Is it Lupus Yet? The What What is this?
More informationAutoimmune Hepatobiliary Diseases PROF. DR. SABEHA ALBAYATI CABM,FRCP
Autoimmune Hepatobiliary Diseases PROF. DR. SABEHA ALBAYATI CABM,FRCP Autoimmune hepatobiliary diseases The liver is an important target for immunemediated injury. Three disease phenotypes are recognized:
More informationIdiopathic inflammatory myopathies are a group of autoimmune
Approach to Diagnosis and Management of an Idiopathic Inflammatory Myopathy Case Study and Commentary, Carrie Edelman, MD Idiopathic inflammatory myopathies are a group of autoimmune diseases characterized
More informationAnnual Rheumatology & Therapeutics Review for Organizations & Societies
Annual Rheumatology & Therapeutics Review for Organizations & Societies Update on Granulomatosis with Polyangiitis (Wegener s) Learning Objectives Identify the clinical features of granulomatosis with
More informationCASE REPORT. Introduction. Case Report
doi: 10.2169/internalmedicine.9553-17 http://internmed.jp CASE REPORT Successful Treatment of Rapidly Progressive Unclassifiable Idiopathic Interstitial Pneumonia with Anti-melanoma Differentiation-associated
More informationOverview of Diagnostic Autoantibodies in Inflammatory Myopathy
Overview of Diagnostic Autoantibodies in Inflammatory Myopathy Minoru Satoh, M.D., Ph.D. Research Associate Professor of Medicine Division of Rheumatology and Clinical Immunology University of Florida
More informationCHECK LIST FORM-SCREENING
CHECK LIST FORM-SCREENING Participant Initials: Date of Birth: Evaluation Date: Were the following forms completed for this visit? Eligibility Form Done t Done Baseline medical History Form Done t Done
More informationTools to Aid in the Accurate Diagnosis of. Connective Tissue Disease
Connective Tissue Disease Tools to Aid in the Accurate Diagnosis of Connective Tissue Disease Connective Tissue Disease High quality assays and novel tests Inova offers a complete array of assay methods,
More information*Pari Basharat ABSTRACT OVERVIEW OF IDIOPATHIC INFLAMMATORY MYOPATHIES
IDIOPATHIC INFLAMMATORY MYOPATHIES: ASSOCIATION WITH OVERLAP MYOSITIS AND SYNDROMES: CLASSIFICATION, CLINICAL CHARACTERISTICS, AND ASSOCIATED AUTOANTIBODIES *Pari Basharat University of Western Ontario,
More informationEveryday Vasculitis (or what questions do we get asked most!) Lucy Smyth Renal Consultant
Everyday Vasculitis (or what questions do we get asked most!) Lucy Smyth Renal Consultant What is it? Why have I got it? How can we treat it? Why do I feel like I do? What do the blood tests mean? Will
More informationDiseases of Muscle and Neuromuscular Junction
Diseases of Muscle and Neuromuscular Junction Diseases of Muscle and Neuromuscular Junction Neuromuscular Junction Muscle Myastenia Gravis Eaton-Lambert Syndrome Toxic Infllammatory Denervation Atrophy
More informationReporting Autoimmune Diseases in Hematopoietic Stem Cell Transplantation
Reporting Autoimmune Diseases in Hematopoietic Stem Cell Transplantation Marcelo C. Pasquini, MD, MSc HVD05_1.ppt Outline Review of autoimmune diseases (AID). Role of transplantation for AID Data collection:
More informationRheumatology Primer: What Labs and When
Rheumatology Primer: What Labs and When Irina Konon, MD Department of Internal Medicine Division of Rheumatology Medical College of Wisconsin Disclosures None 1 Objective Discuss principles of laboratory
More informationMYOSITIS 101. Your guide to understanding myositis
MYOSITIS 101 Your guide to understanding myositis Patients who are informed, who seek out other patients, and who develop helpful ways of communicating with their doctors have better outcomes. Because
More informationVasculitides in Surgical Neuropathology Practice
Vasculitides in Surgical Neuropathology Practice USCAP requires that all faculty in a position to influence or control the content of CME disclose any relevant financial relationship WITH COMMERCIAL INTERESTS
More informationSkin Manifestations of Dermatomyositis. Victoria P. Werth, M.D. University of Pennsylvania. Chief, Dermatology Philadelphia VAMC
Skin Manifestations of Dermatomyositis Victoria P. Werth, M.D. University of Pennsylvania Chief, Dermatology Philadelphia VAMC Overview Pathogenesis: Inflammatory cells in the skin, Interferon, medications
More informationDepartment of Paediatrics Clinical Guideline
Department of Paediatrics Clinical Guideline The child and young person with possible arthritis (joint swelling and/or pain, loss of function for >4 weeks) Definition: Juvenile Idiopathic Arthritis (JIA)
More informationDisclosures. Outline. Classification of scleroderma. Forms of SSc Like Syndromes. Systemic Sclerosis (Scleroderma)
Update in Rheumatic Diseases Scleroderma/Sjogrens/Myositis Intensive Review of Internal Medicine August 2012 Paul F Dellaripa MD Division of Rheumatology, Brigham and Women s Hospital, Boston MA Disclosures
More informationA RARE NEUROLOGICAL PRESENTATION OF SLE. Dr Yoganand M N Dr Prithvi P Nayak
A RARE NEUROLOGICAL PRESENTATION OF SLE Dr Jayachandra Dr Yoganand M N Dr Prithvi P Nayak Presenter: Dr Shambhavi K R CHIEF COMPLAINTS A 30 year old lady hailing from Nepal presented to OPD with complaints
More informationVasculitis and Vasculitides. OMONDI OYOO Physician/Rheumatologist; Senior Lecturer, Department of Medicine University of Nairobi
Vasculitis and Vasculitides OMONDI OYOO Physician/Rheumatologist; Senior Lecturer, Department of Medicine University of Nairobi Definition Presence of leucocytes in the vessel wall with reactive damage
More informationTest Name Results Units Bio. Ref. Interval
135091660 Age 44 Years Gender Male 29/8/2017 120000AM 29/8/2017 100219AM 29/8/2017 105510AM Ref By Final EXTRACTABLENUCLEAR ANTIGENS (ENA), QUANTITATIVE ROFILE CENTROMERE ANTIBODY, SERUM 20-30 Weak ositive
More informationAPPROACH TO PATIENTS WITH POLYARTHRALGIA
APPROACH TO PATIENTS WITH POLYARTHRALGIA Scott Vogelgesang, MD Division of Immunology University of Iowa No conflicts of interest DEFINITIONS Arthralgia joint pain with no evidence of inflammation Arthritis
More informationUnderstanding Myositis Medications
Understanding Myositis Medications 2015 TMA Annual Patient Conference Orlando, Florida Chester V. Oddis, MD University of Pittsburgh Director, Myositis Center Disclosures Mallinckrodt: Research Grant Genentech:
More informationRituximab Therapy for Myopathy Associated With Anti Signal Recognition Particle Antibodies: A Case Series
Arthritis Care & Research Vol. 62, No. 9, September 2010, pp 1328 1334 DOI 10.1002/acr.20219 2010, American College of Rheumatology ORIGINAL ARTICLE Rituximab Therapy for Myopathy Associated With Anti
More information