Understanding pathogenesis to develop treatments for respiratory diseases
|
|
|
- Helena Dixon
- 6 years ago
- Views:
Transcription
1 Understanding pathogenesis to develop treatments for respiratory diseases Phil Hansbro Research Centre for Healthy Lungs Univ of Newcastle & Hunter Medical Research Institute NSW, Australia 1
2 Aims Aim to develop effective preventions & treatments for COPD, asthma, infections, lung cancer Develop representative mouse models of human disease, interrogate, find new targets & develop new pharmaceutics Parallel human ex vivo & in vitro studies validate 2
3 Mouse model of COPD Directly expose airways to CS, smoke 2h/day, 5 d/wk, BALB/c or C57BL/6 mice Wk Air controls Cigarette smoke treated 3 Beckett J Allergy Clin Immunol 2013, Hansbro JBC 2014, Franklin Nat Immunol 3014, Hsu AJRCCM 2015, Haw Mucosal Immunol 2016, Liu JCI Insight 2017
4 numbers Develops hallmark features of Human COPD * Cells/ml BALF (10 4 ) ** 4 2 Air Smk M N L M N L d 8 wks atment TNFa (relative expression) wk 6wk 8wk 12wk MSCs (fold change from control) wk ** 6wk 8wk 12wk Control COPD 100 um 100 um Beckett J Allergy Clin Immunol 2013, Hansbro J Biol Chem 2014, Franklin Nat Immunol 2014, 4 Hsu Am J Respir Crit Care Med 2015, Haw Mucosal Immunol 2016
5 Emphysema & reduced lung function Control Smoke Airway RI (cmh 2 O.s/ml) weeks Transpulmonary RI (cmh 2 O.s/ml) cells/lung lobe Hysteresis (cmh 2 0.%maxVpl) Alveolar diameter (mm) Lung mast cell numbers 0 4wk * Weeks of treatment * * 6wk 8wk 12wk Work of breathing (abitrary units) ** Air Smk Beckett J Allergy Clin Immunol 2013, Hansbro J Biol Chem 2014, Franklin Nat Immunol 2014, 5 Hsu Am J Respir Crit Care Med 2015, Haw/Starkey Mucosal Immunol 2016, Liu JCI Insight 2017
6 COPD pathogenesis Findings Mast cell proteases Trypase-b & g: Beckett JACI 2013, Hansbro JBC 2014 ASC specks/inflammasomes: Franklin Nat Immunol 2014 Amine oxidase & inhibitors: Jarnicki Br J Pharm 2016 Fibulin-1c in remodelling & emphysema also IPF & asthma: Liu JCI Insight 2016 TRAIL & inhibitors: Haw/Starkey Mucosal Immunol 2016 COPD exacerbations mirna-125a/b inhibit A20 & MAVS to promote viral infection in COPD: Hsu JCI Insight 2017 SOCS5 suppresses influenza in COPD by inhibiting EGFR: Kedzierski elife 2017 Ongoing Microbiomes: Budden Nat Rev Microbiol 2017 mirnas, acetylation, proteomics, immunometabolism, ox stress 6
7 Refined model DEX (d32, 33, 34) d35 Endpoints d0 Sal/Ova i.p. d12, 13 Ova i.n. Cmu/Hinf/Flu SPG/Cmu (d14) /RSV Groups Ova Ova/DEX Ova/Cmu, Ova/Hinf, Ova/Flu, Ova/RSV Ova/Cmu/DEX, Ova/Hinf/DEX, Ova/Flu/DEX, Ova/RSV/DEX d33, 34 Ova i.n. Sham-infected controls receive vehicle for infections (SPG, PBS, Media) 7 Essilfie, Horvat Thorax 2015, Kim, Horvat J Allergy Clin Immunol
8 Chlamydia respiratory infection induces severe, neutrophilic, steroid-resistant AAD (SSRAAD) Chlamydia-induced SSRAAD: T H 1/T H 17-associated responses neutrophils, eosinophils Steroid-resistant airway inflammation & AHR Essilfie, Horvat Thorax 2015, Kim, Horvat J Allergy Clin Immunol
9 Investigation of Infection-associated, steroid-resistant asthma Chlamydia-induced neutrophilic SSRAAD Th1/Th17 & Th2 responses Haemophilus-induced neutrophilic SSRAAD Th17 & Th2 responses Influenza & RSV -induced eosinophilic SSRAAD Th1 & Th2 responses Used to discover mechanisms of pathogenesis & treatment targets (mirnas, epigenetics, inflammasomes) Microarrays & RNA-seq to correlate with human phenoptypes 9
10 Severe asthma Essilfie Thorax 2015 Kim, Horvat J Allergy Clin Immunol 2017 Kim Am J Respir Crit Care Med
11 Early life Chlamydia respiratory infection-induced chronic lung disease in mice 0 day, 3 week, 6 week C. muridarum profile 9wk old C. muridarum (Cmu) or sham-inoculation (SPG) Infection only Day 0 20 Inflammation profile Assess lung structure and function Ova sensitisation Ova challenge Ova-induced AAD CS-exposure 16wk old CS-induced experimental COPD Horvat AJRCCM 2007 Horvat/Starkey JACI 2010 Starkey/Haw Mucosal Immunol 2015 Starkey AJRCMB
12 Published & ongoing studies Neonatal & infant infection infection causes long term changes: immunity (switches T cell phenotype, modifies DC function), alveolar enlargement AHR increases severity of subsequent AAD In infants roles for IL-13 & TRAIL, inhibition suppresses features & subsequent AAD Horvat AJRCCM 2007, Horvat/Starkey JACI 2010, Starkey Mucosal Immunol 2013, 2014 IL-13, ILCs, TLR2, epigenetics, proteomics 12
13 Summary Early-life infection TLR2 IL-13 + ILC2s IL-13Rα1 Stat6 mir-21 Impaired lung function
14 Early-life asthma Jay Horvat Malcolm Starkey Richard Kim Duc Nguyen Severe asthma Jay Horvat Richard Kim James Pinkerton Ama Essilfie COPD Mike Fricker Emma Beckett Andrew Jarnicki Kurtis Budden Kamal Dua Rest of Hansbro group NHMRC, Asthma Fnd NSW, ARC Newcastle Paul Foster Peter Gibson & Katie Baines Peter Wark Darryl Knight Joerg Mattes Mast cells Rick Stevens - Harvard Microbiomes Phil Hugenholtz UQ Paul Dennis - UQ Mark Morrison UQ Inflammasomes Matt Cooper UQ Avril Robertson - UQ Luke O Neill Trinity Coll Ireland Eicke Latz Univ Bonn Omics data Sally Wenzel - Pittsburgh Ian Adcock Newcastle/Imperial DFCO Wayne Metzner Johns Hopkins 14
Macrolide therapy suppresses key features of experimental steroid-sensitive and steroid-insensitive asthma
Editor s choice Scan to access more free content Additional material is published online only. To view please visit the journal online (http://dx.doi.org/10.1136/ thoraxjnl-2014-206067). Centre for Asthma
MicroRNA-21 drives severe, steroid-insensitive experimental asthma by amplifying PI3K-mediated suppression of HDAC2
Accepted Manuscript MicroRNA-21 drives severe, steroid-insensitive experimental asthma by amplifying PI3K-mediated suppression of HDAC2 Richard Y. Kim, PhD, Jay C. Horvat, PhD, James W. Pinkerton, B Biomed
Mechanisms and treatments for severe, steroid- resistant allergic airway disease and asthma
DOI: 10.1111/imr.12543 INVITED REVIEW Mechanisms and treatments for severe, steroid- resistant allergic airway disease and asthma Philip M. Hansbro 1 Richard Y. Kim 1 Malcolm R. Starkey 1 Chantal Donovan
Identifying Biologic Targets to Attenuate or Eliminate Asthma Exacerbations
Identifying Biologic Targets to Attenuate or Eliminate Exacerbations exacerbations are a major cause of disease morbidity and costs. For both children and adults, viral respiratory infections are the major
Tumor necrosis factor-related apoptosis-inducing ligand translates neonatal respiratory infection into chronic lung disease
nature publishing group Tumor necrosis factor-related apoptosis-inducing ligand translates neonatal respiratory infection into chronic lung disease MR Starkey 1, DH Nguyen 1, AT Essilfie 1, RY Kim 1, LM
COPD, Asthma, Or Something In Between? Sharon R. Rosenberg Assistant Professor of Medicine Northwestern University December 4, 2013
COPD, Asthma, Or Something In Between? Sharon R. Rosenberg Assistant Professor of Medicine Northwestern University December 4, 2013 None Disclosures Definitions Asthma Asthma is a chronic inflammatory
Airway macrophages in health and disease Tracy Hussell
Prof. Airway Macrophages in Health and Disease Director, Manchester Collaborative Centre for Inflammation Research (MCCIR), Professor of Inflammatory Disease University of Manchester Manchester, M13 9PT
Asthma is a major chronic respiratory. Streptococcus pneumoniae infection suppresses allergic airways disease by inducing regulatory T-cells
Eur Respir J 11; 7: DOI: 1.11/919.91 CopyrightßERS 11 Streptococcus pneumoniae infection suppresses allergic airways disease by inducing regulatory T-cells J.A. Preston*,, A.N. Thorburn*,, M.R. Starkey*,
Severe Asthma(s): Can THEY be prevented or reversed?
Severe Asthma(s): Can THEY be prevented or reversed? Sally Wenzel, MD Professor of Medicine UPMC Chair in Translational Airway Biology Disclosures Sally Wenzel, M.D. Grant/Research Support: Boehringer-Ingelheim,
Asthma and obesity, implications for airway inflammation and Bronchial Hyperresponsiveness
Asthma and obesity, implications for airway inflammation and Bronchial Hyperresponsiveness Fernando Holguin MD MPH Asthma Institute University of Pittsburgh Obesity Trends* Among U.S. Adults BRFSS, 1990,
Emerging roles of pulmonary macrophages in driving the development of severe asthma
Review Emerging roles of pulmonary macrophages in driving the development of severe asthma Ming Yang,*,1 Rakesh K. Kumar, Philip M. Hansbro,*,2 and Paul S. Foster*,2 *Centre for Asthma and Respiratory
Professor Richard Beasley
Professor Richard Beasley University of Otago Director Medical Research Institute of New Zealand Wellington 14:00-14:55 WS #111: Towards Precision Medicine in Asthma -Treatable Traits 15:05-16:00 WS #121:
Heterogeneity of COPD and Asthma
Heterogeneity of COPD and Asthma from Heterogeneity to Stratification Dr. Y-M Oh Asan Medical Center Seoul Congratulations & Welcome Lee,SD Ohno, Y Park, JS Seo, JB 8 th Internat nal Workshop on Pul. Functional
Mechanisms of action of bronchial provocation testing
Mechanisms of action of bronchial provocation testing TSANZ / ANZSRS Masterclass: April 3rd, 2016 13:00 13:30 John D. Brannan PhD Scientific Director - Dept. Respiratory & Sleep Medicine John Hunter Hospital,
Current Asthma Therapy: Little Need to Phenotype. Phenotypes of Severe Asthma. Cellular Phenotypes 12/7/2012
Subbasement Membrane Thickness(µm) 12/7/212 Current Asthma Therapy: Little Need to Phenotype Phenotypes of Severe Asthma Most mild and to some degree moderate asthmatics respond well to currently available
COPD and Asthma: Similarities and differences Prof. Peter Barnes
and Asthma: Similarities and Differences and Asthma: 1 Imperial College Peter Barnes FRS, FMedSci, National Heart & Lung Institute Imperial College, London, UK p.j.barnes@imperial.ac.uk Royal Brompton
Microbiome and Asthma
제 12 차천식연구회 COPD 연구회공동심포지엄 Microbiome and Asthma 한양대학교병원호흡기알레르기내과 김상헌 Disclosure 내용 1 Lung Microbiome 2 Lung Microbiome and Asthma 3 Gut Microbiome and Asthma Microbiome and Microbiota human microbiome
COPD: From Phenotypes to Endotypes. MeiLan K Han, M.D., M.S. Associate Professor of Medicine University of Michigan, Ann Arbor, MI
COPD: From Phenotypes to Endotypes MeiLan K Han, M.D., M.S. Associate Professor of Medicine University of Michigan, Ann Arbor, MI Presenter Disclosures MeiLan K. Han Consulting Research support Novartis
COPD or not COPD, that is the question.
COPD or not COPD, that is the question. Asthma-COPD Overlap Syndrome: ACOS Do we really need this? Michelle Harkins Disclosure Slide Slide help - William Busse, MD Organizational Interests ATS, ACCP, ACP
Gut Lung Axis Implication of the Gut Microbiota beyond its niche
Gut Lung Axis Implication of the Gut Microbiota beyond its niche Reema Subramanian PhD Candidate (4 th year) Supervisor: Prof. Margaret Ip Department of Microbiology, CUHK Joint Graduate Student Seminar
Potential public health impact of RSV vaccines. R. Karron December 2016
Potential public health impact of RSV vaccines R. Karron December 2016 1. RSV is The leading cause of hospitalization in infants and in many high-income countries; >2 million medical visits annually in
Class of We are pleased to provide support for the following new investigators who make up the Parker B. Francis Fellowship Class of 2016.
The Parker B. Francis Fellowship Program provides career development support to M.D. and Ph.D. scientists embarking on careers in clinical, laboratory or translational science related to Pulmonary, Critical
The Journal Club: COPD Exacerbations
252 The Journal Club: COPD Exacerbations Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation Journal Club The Journal Club: COPD Exacerbations Ron Balkissoon, MD, MSc, DIH, FRCPC 1 Abbreviations:
Defining Asthma: Clinical Criteria. Defining Asthma: Bronchial Hyperresponsiveness
Defining Asthma: Clinical Criteria Atopy 34% Recent wheeze 20% Asthma 11% AHR 19% n = 807 From: Woolcock, AJ. Asthma in Textbook of Respiratory Medicine, 2nd ed. Murray, Nadel, eds.(saunders:philadelphia)
Diagnosis and Management of Fungal Allergy Monday, 9-139
Diagnosis and Management of Fungal Allergy Monday, 9-139 13-2010 Alan P. Knutsen,, MD Director, Pediatric Allergy & Immunology Director, Jeffrey Modell Diagnostic Center for Primary Immunodeficiencies
Ioana Agache Transylvania University Brasov. Precision medicine in allergy and asthma
Ioana Agache Transylvania University Brasov Precision medicine in allergy and asthma Precision medicine and precision health Personalized care based on molecular, immunologic and functional endotyping
Pediatric Asthma. Fernando D. Mar,nez, M.D. Asthma and Airways Disease Research Center The University of Arizona
Pediatric Asthma Fernando D. Mar,nez, M.D. Asthma and Airways Disease Research Center The University of Arizona Disclosure Grant from Johnson and Johnson to study use of Amish dust to prevent asthma Advisor
Precision Asthma Therapy: Picking the Right Biologic for the Right Patient. The Asthma Umbrella. Asthma. Late onset. Early onset.
recision Asthma Therapy: icking the Right Biologic for the Right atient The Asthma Umbrella Asthma arly onset Late onset Symptoms xacerbations FV1 T H 2 inflammation No or less T H 2 inflammation henotype
Phenotypes of asthma; implications for treatment. Medical Grand Rounds Feb 2018 Jim Martin MD DSc
Phenotypes of asthma; implications for treatment Medical Grand Rounds Feb 2018 Jim Martin MD DSc No conflicts to declare Objectives To understand the varied clinical forms of asthma To understand the pathobiologic
WHAT ARE THE PHYSIOLOGICAL DETERMINANTS OF EXPIRATORY FLOW?
Lung Volume the physiology of breathing: OBSTRUCTIVE LUNG DISORDERS Dr. Andrew Fon MBBS FRACP Respiratory and Sleep Medicine Physician PhD Research Fellow Dept. of Thoracic Medicine, ROYAL ADELAIDE HOSPITAL
Epidemic of Asthma in Pittsburgh
Epidemic of Asthma in Pittsburgh Deborah A. Gentile, MD Associate Professor of Medicine Temple University School of Medicine Director of Clinical Research Division of Allergy, Asthma, Immunology Department
Chronic respiratory disease: towards better treatments
Chronic respiratory disease: towards better treatments Alaina J. Ammit PhD Alaina.Ammit@uts.edu.au Professor of Respiratory Pharmacology, UTS Director, Woolcock Emphysema Centre, Woolcock Institute of
Asthma Phenotypes, Heterogeneity and Severity: The Basis of Asthma Management
Asthma Phenotypes, Heterogeneity and Severity: The Basis of Asthma Management Eugene R. Bleecker, MD Professor and Director, Center for Genomics & Personalized Medicine Research Professor, Translational
Diet, Obesity and Asthma: evidence based advice on healthy eating for asthma A/Prof Lisa Wood
Diet, Obesity and Asthma: evidence based advice on healthy eating for asthma A/Prof Lisa Wood Centre for Asthma and Respiratory Disease University of Newcastle and Hunter Medical Research Institute NSW
Personalized medicine in childhood asthma. Dr Mariëlle Pijnenburg, Erasmus MC Sophia, Rotterdam, NL
Thank you for viewing this presentation. We would like to remind you that this material is the property of the author. It is provided to you by the ERS for your personal use only, as submitted by the author.
APSR RESPIRATORY UPDATES
APSR RESPIRATORY UPDATES Volume 5, Issue 7 Newsletter Date: July 2013 APSR EDUCATION PUBLICATION Inside this issue: Induced sputum A large subgroup of mild-to-moderate asthma is persistently noneosinophilic
PKU: Yahong Chen, MD, PhD UM: Steven K. Huang, MD
DNA Methylation Changes Induced by Particulate Matter in Air Pollution Contributes to Chronic Airway Inflammation in Moderate-to-Severe Uncontrolled Asthma PKU: Yahong Chen, MD, PhD UM: Steven K. Huang,
Update on Immunology 12/31/12. Disclosures. Outline. Outline. Outline. Pathophysiology of Allergic Disease. Allergy background Novel T cell subsets
Update on Immunology Mitchell H. Grayson, MD Associate Professor Medical College of Wisconsin Dec 2012 Disclosures Employer Medical College of Wisconsin Research support National Institutes of Health $100,000
Allergen and Environment in Severe Asthma
Allergen and Environment in Severe Asthma Hye-Ryun Kang MD., PhD. Department of Internal Medicine, Seoul National University Hospital Role of Allergen in Asthma Pathogenesis Early response of allergen
Defining COPD. Georgina Grantham Community Respiratory Team Leader/ Respiratory Nurse Specialist
Defining COPD Georgina Grantham Community Respiratory Team Leader/ Respiratory Nurse Specialist Defining COPD Chronic Obstructive Pulmonary Disease (COPD) is a common, preventable and treatable disease
Exhaled Nitric Oxide: An Adjunctive Tool in the Diagnosis and Management of Asthma
Exhaled Nitric Oxide: An Adjunctive Tool in the Diagnosis and Management of Asthma Jason Debley, MD, MPH Assistant Professor, Pediatrics Division of Pulmonary Medicine University of Washington School of
Searching for Targets to Control Asthma
Searching for Targets to Control Asthma Timothy Craig Distinguished Educator Professor Medicine and Pediatrics Penn State University Hershey, PA, USA Inflammation and Remodeling in Asthma The most important
Effects of omalizumab on RV infections, illnesses, and exacerbations of asthma. James Gern, MD Ann Esquivel, MD University of Wisconsin, Madison
Effects of omalizumab on RV infections, illnesses, and exacerbations of asthma James Gern, MD Ann Esquivel, MD University of Wisconsin, Madison Background: Omalizumab Mechanism of Action Primary Mechanism
Outcome, classification and management of wheezing in preschool children Paul L.P. Brand
Outcome, classification and management of wheezing in preschool children Paul L.P. Brand Princess Amalia Children s Clinic Isala klinieken, Zwolle the Netherlands p.l.p.brand@isala.nl Valle de la Luna,
an inflammation of the bronchial tubes
BRONCHITIS DEFINITION Bronchitis is an inflammation of the bronchial tubes (or bronchi), which are the air passages that extend from the trachea into the small airways and alveoli. Triggers may be infectious
1/30/2016 RESPIRATORY INFECTIONS AND ASTHMA NO DISCLOSURES NO FINANCIAL INTEREST INFORMATION OBTAINED JACI AJRCCM
RESPIRATORY INFECTIONS AND ASTHMA NO DISCLOSURES NO FINANCIAL INTEREST INFORMATION OBTAINED JACI AJRCCM 1 2 year old male HISTORY -Daycare since 9 months of age -Recurrent symptoms since 10 months of age:
EARN 3 FREE CPD POINTS
EARN 3 FREE CPD POINTS asthma and allergy Leader in digital CPD for Southern African healthcare professionals Asthma and allergy: Influence of EARLY LIFE RISK EXPOSURE Professor Peter Sly Director: World
The FDA Critical Path Initiative
The FDA Critical Path Initiative Clinical Considerations for Demonstration of Dose-response for Inhaled Corticosteroids - Exhaled Nitric Oxide Model Badrul A. Chowdhury, MD, PhD Director Division of Pulmonary
Different inflammatory phenotypes in adults and children with acute asthma
Eur Respir J 211; 38: 567 574 DOI: 1.1183/931936.1711 CopyrightßERS 211 Different inflammatory phenotypes in adults and children with acute asthma F. Wang*,#,", X.Y. He #,", K.J. Baines #,", L.P. Gunawardhana
Update on Biologicals for ABPA and Asthma
Update on Biologicals for ABPA and Asthma 5 th Advances Against Aspergillosis Istanbul 27 Jan 2012 Richard B. Moss MD Professor of Pediatrics Stanford University Palo Alto CA USA Disease of chronic airway
Potent and Selective CRTh2 Antagonists are Efficacious in Models of Asthma, Allergic Rhinitis and Atopic Dermatitis
Potent and Selective CRTh2 Antagonists are Efficacious in Models of Asthma, Allergic Rhinitis and Atopic Dermatitis Laura L. Carter, Yoshi Shiraishi, Yooseob Shin, Laurence Burgess, Christine Eberhardt,
Biologics in asthma Are we turning the corner? Roland Buhl Pulmonary Department Mainz University Hospital
Biologics in asthma Are we turning the corner? Roland Buhl Pulmonary Department Mainz University Hospital Biologics in asthma - are we turning the corner? Allergic asthma anti - IgE Allergic airway inflammation
MicroRNA-125a and -b inhibit A20 and MAVS to promote inflammation and impair antiviral response in COPD
MicroRNA-125a and -b inhibit A20 and MAVS to promote inflammation and impair antiviral response in COPD Alan C-Y. Hsu,, Philip M. Hansbro, Peter A. Wark JCI Insight. 2017;2(7):e90443.. Research Article
Distinguishing Type-2 Asthma
UPDATE ON ASTHMA THERAPY: MATCHING PHENOTYPE TO TREATMENT Sally E. Wenzel, MD Professor of Medicine University of Pittsburgh Asthma Institute@UPMC Subsection Chief of Allergy 1234567 891234 567891 2345678
Understanding How Allergic Responses End: The Allergy Resolvome. Lipid mediators
Understanding How Allergic Responses End: The Allergy Resolvome Lipid mediators Koichiro Asano Tokai University School of Medicine, Kanagawa, JAPAN ko-asano@tokai-u.jp Resolution of granulocytic inflammation
The Upper Airway. Trachea. The Human Airway. Nasopharynx Oropharynx Larynx
The Human Airway (with thanks to David N. Hager, MD, PhD Johns Hopkins University) The Upper Airway Nasopharynx Oropharynx Larynx voice airflow Gray, Anatomy of the Human Body Trachea Length: 9-15 cm Internal
The Link Between Viruses and Asthma
The Link Between Viruses and Asthma CATHERINE KIER, MD Professor of Clinical Pediatrics Division Chief, Pediatric Pulmonary, and Cystic Fibrosis Center Director, Pediatric Sleep Disorders Center SUNY Stony
Viral infections in airway remodeling
Viral infections in airway remodeling Nikos Papadopoulos As. Proffesor,Head, Allergy Dpt, 2 nd Pediatric Clinic, University of Athens Overview Acute events may have long term consequences Remodeling appears
Asthma and the Airway Microbiome: New Insights and Hypotheses
Asthma and the Airway Microbiome: New Insights and Hypotheses Yvonne J. Huang, MD Division of Pulmonary and Critical Care Medicine Department of Internal Medicine University of Michigan, Ann Arbor 3 rd
TORCH: Salmeterol and Fluticasone Propionate and Survival in COPD
TORCH: and Propionate and Survival in COPD April 19, 2007 Justin Lee Pharmacy Resident University Health Network Outline Overview of COPD Pathophysiology Pharmacological Treatment Overview of the TORCH
Potential risks of ICS use
Potential risks of ICS use Randomised controlled trial Observational study Systematic review Pneumonia Tuberculosis Bone fracture Skin thinning/easy bruising Cataract Diabetes No effect on fracture risk
Life-long asthma and its relationship to COPD. Stephen T Holgate School of Medicine University of Southampton
Life-long asthma and its relationship to COPD Stephen T Holgate School of Medicine University of Southampton Definitions COPD is a preventable and treatable disease with some significant extrapulmonary
Respiratory Toxicology
Respiratory Toxicology Loch-Caruso ENVIRON 310 2017 1 Breathing Oxygen Carbon Dioxide http://www.webmd.com/lung/picture-of-the-lungs Loch-Caruso ENVIRON 310 2017 2 Breathing Enlarged view of the airways,
Distinction and Overlap. Allergy Dpt, 2 nd Pediatric Clinic, University of Athens
Asthma Phenotypes: Distinction and Overlap Nikos Papadopoulos Allergy Dpt, 2 nd Pediatric Clinic, University of Athens Asthma as a syndrome From the Iliad to ADAM 33 and back again Bronchoconstriction,
Allergic Rhinitis and Its Impact on Ast. Rhinitis: A Risk Factor for Asthma? Ronald Dahl, Aarhus University Hospital, Denmark
Allergic Rhinitis and Its Impact on Ast Rhinitis: A Risk Factor for Asthma? Ronald Dahl, Aarhus University Hospital, Denmark Rhinitis and asthma SIT-SLIT Evidence A SIT-SLIT Evidence A? SIT Evidence? Rhinitis
Diet, Obesity and Asthma
Diet, Obesity and Asthma A/Prof Lisa Wood Centre for Asthma and Respiratory Disease University of Newcastle and Hunter Medical Research Institute NSW Australia email: lisa.wood@newcastle.edu.au OUTLINE:
Pulmonary Immunology. Chad Steele, Ph.D ; THT 437A
Pulmonary Immunology Chad Steele, Ph.D. 6-9598; THT 437A chadsteele@uab.edu Outline Significance of lung diseases Uniqueness of the lung: MCC, alveolar macrophages Asthma COPD/emphysema Intermingled Steele
How Gut Microbes Alter the Risks of RSV Infection and Asthma in Mice and Men
How Gut Microbes Alter the Risks of RSV Infection and Asthma in Mice and Men Dennis R. Ownby MD Medical College of Georgia at Augusta University Disclosures No commercial financial relationships No discussion
An Update on Topical Therapy for Atopic Dermatitis
An Update on Topical Therapy for Atopic Dermatitis Amy S. Paller, M.D. Professor and Chair of Dermatology Professor of Pediatrics Northwestern University Feinberg School of Medicine Chicago, Illinois Disclosures
Asthma Update A/Prof. John Abisheganaden. Senior Consultant, Dept Of Respiratory & Crit Care Medicine Tan Tock Seng Hospital
Asthma Update - 2013 A/Prof. John Abisheganaden Senior Consultant, Dept Of Respiratory & Crit Care Medicine Tan Tock Seng Hospital Asthma A complex syndrome Multifaceted disease Heterogeneous Genetic and
Airway Inflammation in Asthma Chih-Yung Chiu 1,2, Kin-Sun Wong 2 1 Department of Pediatrics, Chang Gung Memorial Hospital, Keelung, Taiwan.
REVIEW ARTICLE Chih-Yung Chiu 1,2, Kin-Sun Wong 2 1 Department of Pediatrics, Chang Gung Memorial Hospital, Keelung, Taiwan. 2 Division of Pediatric Pulmonology, Department of Pediatrics, Chang Gung Memorial
B Y L E S L I E K U M P F, R R T, C P F T, A E - C
FeNO B Y L E S L I E K U M P F, R R T, C P F T, A E - C LESLIE KUMPF RRT, CPFT, AE-C Graduated from Henry Ford with a degree in Respiratory Therapy in 2006 Currently working on my BSRT Help start the RRT
Role of C5 in the development of airway inflammation, airway hyperresponsiveness, and ongoing airway response
Research article Role of C5 in the development of airway inflammation, airway hyperresponsiveness, and ongoing airway response Tao Peng, 1 Liming Hao, 2 Joseph A. Madri, 2 Xiao Su, 1 Jack A. Elias, 3 Gregory
7/7/2015. Somboon Chansakulporn, MD. History of variable respiratory symptoms. 1. Documented excessive variability in PFT ( 1 test)
Definition of Asthma GINA 2010: Chronic inflammatory disorder of the airways Airway hyper-responsiveness Recurrent wheezing, breathlessness, chest tightness, coughing Variable, reversible airflow obstruction
The inhibitor of semicarbazide-sensitive amine oxidase, PXS-4728A, ameliorates key features of chronic obstructive pulmonary disease in a mouse model
British Journal of Pharmacology RESEARCH PAPER British Journal of Pharmacology (2016) 173 3161 3175 3161 The inhibitor of semicarbazide-sensitive amine oxidase, PXS-4728A, ameliorates key features of chronic
COPD: A Renewed Focus. Disclosures
COPD: A Renewed Focus Heath Latham, MD Assistant Professor Division of Pulmonary and Critical Care Medicine Disclosures No Business Interests No Consulting No Speakers Bureau No Off Label Use to Discuss
International Symposium of Environmental Medicine
International Symposium of Environmental Medicine Including Asthma, Rhinitis Eczema, Uti Urticaria i (hives) Drug, Food, and Insect allergy Asthma: ~3 3 10 8 patients in the world 250,000 asthma deaths
n Definition of asthma control n Main causes of asthma exacerbations n Physiopathology & treatment targets n How to prevent/manage exacerbations
Control and prevention of asthma exacerbations Louis-Philippe Boulet MD FRCPC FCCP Quebec Heart & Lung Institute Quebec City, Canada Synopsis Definition of asthma control Main causes of asthma exacerbations
Pro/Con: Pets Prevent Allergies and Asthma
Slide 1 Pro/Con: Pets Prevent Allergies and Asthma Slide 2 Special thanks to: n Dr. Dennis Ownby n Dr. Matt Perzanowski n Dr. Erica von Mutius and Dr. Charlotte Braun-Fahrlander n Dr. Andy Liu n Colleagues
SEVERE ASTHMA NUCALA 100MG SUBCUTANEOUS INJECTION THE FIRST TARGETED ANTI IL-5 ADD-ON TREATMENT FOR ADULTS WITH SEVERE REFRACTORY EOSINOPHILIC ASTHMA
SEVERE ASTHMA NUCALA 100MG SUBCUTANEOUS INJECTION THE FIRST TARGETED ANTI ADD-ON TREATMENT FOR ADULTS WITH SEVERE REFRACTORY EOSINOPHILIC ASTHMA FIND OUT MORE VISIT - WWW.NUCALA.CO.UK Vial not actual size
Cigarette smoke selectively enhances viral PAMP and virus-induced pulmonary innate immune and remodeling responses in mice
Related Commentary, page 2689 Research article Cigarette smoke selectively enhances viral PAMP and virus-induced pulmonary innate immune and remodeling responses in mice Min-Jong Kang, 1 Chun Geun Lee,
The case for extra fine particle ICS:! to cover the entire lung!
The case for extra fine particle ICS: to cover the entire lung Richard J. Martin, M.D. Chairman Department of Medicine National Jewish Health The Edelstein Chair in Pulmonary Medicine Professor of Medicine
Role of Tyk-2 in Th9 and Th17 cells in allergic asthma
Supplementary File Role of Tyk-2 in Th9 and Th17 cells in allergic asthma Caroline Übel 1*, Anna Graser 1*, Sonja Koch 1, Ralf J. Rieker 2, Hans A. Lehr 3, Mathias Müller 4 and Susetta Finotto 1** 1 Laboratory
Small Airways Disease. Respiratory Function In Small Airways And Asthma. Pathophysiologic Changes in the Small Airways of Asthma Patients
Small Airways Disease Respiratory Function In Small Airways And Relevant Questions On Small Airway Involvement In How can small airway disease be defined? What is the link between small airway abnormalities
The Human Microbiome in Chronic Obstructive Pulmonary Disease (COPD)
The Human Microbiome in Chronic Obstructive Pulmonary Disease (COPD) Jeffrey L. Curtis, M.D. University of Michigan & Ann Arbor VA Healthsystem Ning Shen, M.D. Peking University Third Hospital Outline
Class of We are pleased to provide support for the following new investigators who make up the Parker B. Francis Fellowship Class of 2015.
The Parker B. Francis Fellowship Program provides career development support to M.D. and Ph.D. scientists embarking on careers in clinical, laboratory or translational science related to Pulmonary, Critical
The Clinical Phenotype of Asthma in Obesity. Anne Dixon, MA, BM, BCh
The Clinical Phenotype of Asthma in Obesity Anne Dixon, MA, BM, BCh Outline Epidemiology How obesity effects clinical phenotype Phenotypes of asthma in the obese Obesity Trends* Among U.S. Adults BRFSS,
THE COPD-ASTHMA OVERLAP SYNDROME
THE COPD-ASTHMA OVERLAP SYNDROME NICOLA A. HANANIA, MD, MS, FRCP(C), FCCP, FACP ASSOCIATE PROFESSOR OF MEDICINE DIRECTOR OF ASTHMA & COPD CLINICAL RESEARCH CENTER BAYLOR COLLEGE OF MEDICINE HOUSTON, TX
Original Article Serum Levels of IL-17A Increase in Asthma But Don t Correlate with Serum Level of IgE and Asthma Severity
International Journal of Medical Laboratory 2015;2(1):25-33. Original Article Serum Levels of IL-17A Increase in Asthma But Don t Correlate with Serum Level of IgE and Asthma Severity Masouma Mowahedi
Viral-Induced Asthma:
Viral-Induced : Sorting through the Studies Malcolm R. Sears, MB, FRACP, FRCPC Presented at the Respirology Update Continuing Education Program, January 2005 Viral-associated wheezing is common and not
Advanced Medicine 2016 Lung Transplantation. Paul A Corris Newcastle University Newcastle Upon Tyne UK
Advanced Medicine 2016 Lung Transplantation Paul A Corris Newcastle University Newcastle Upon Tyne UK First Human Lung Transplantation 1963 JAMA 1963;186:1065-74 The lung donor was a NHBD who died from
#1 cause of school absenteeism in children 13 million missed days annually
Asthma Update 2013 Jennifer W. McCallister, MD, FACP, FCCP Associate Professor Pulmonary & Critical Care Medicine The Ohio State University Wexner Medical Center Disclosures None 2 Objectives Review burden
Supplementary Figure S1. Flow cytometric analysis of the expression of Thy1 in NH cells. Flow cytometric analysis of the expression of T1/ST2 and
Supplementary Figure S1. Flow cytometric analysis of the expression of Thy1 in NH cells. Flow cytometric analysis of the expression of T1/ST2 and Thy1 in NH cells derived from the lungs of naïve mice.
Methacholine versus Mannitol Challenge in the Evaluation of Asthma Clinical applications of methacholine and mannitol challenges
Methacholine versus Mannitol Challenge in the Evaluation of Asthma Clinical applications of methacholine and mannitol challenges AAAAI San Antonio Tx February 2013 Catherine Lemière MD, MSc Hôpital du
Allergic diseases and treatment. Feng Qian ( 钱峰 )
Allergic diseases and treatment Feng Qian ( 钱峰 ) fengqian@sjtu.edu.cn Hypersensitivity Antigen Host Adaptive responses protective to the host harmful to the host The deleterious consequences of the adaptive
TALKING POINTS. Ten Reasons Why the Ozone Air Quality Standard Must Be Strengthened
October 22, 2014 TALKING POINTS Ten Reasons Why the Ozone Air Quality Standard Must Be Strengthened 1. The current standard is not protective of public health. The Clean Air Act requires EPA to set National
Step up if needed (first, check adherence, environmental control and comorbid conditions) Patients ASSESS CONTROL. Step down if possible
12/9/212 Pharmacogenomics Treating the Individual Asthma Patient Elliot Israel, M.D. Professor of Medicine Harvard Medical School Brigham & Women s Hospital Partners Asthma Center Too much of a good thing?
Cytokine/anti-cytokine therapy novel treatments for asthma?
REVIEWbph_1219 81..95 British Journal of Pharmacology DOI:10.1111/j.1476-5381.2011.01219.x www.brjpharmacol.org Themed Issue: Respiratory Pharmacology Cytokine/anti-cytokine therapy novel treatments for
E-1 Role of IgE and IgE receptors in allergic airway inflammation and remodeling
E-1 Role of IgE and IgE receptors in allergic airway inflammation and remodeling Ruby Pawankar, MD, Ph.D. FRCP, FAAAAI Prof. Div of Allergy, Dept of Pediatrics Nippon Medical School Tokyo, Japan pawankar.ruby@gmail.com
Innate Immunity and Asthma Type 2 Inflammation in Asthma
Innate Immunity and Asthma Type 2 Inflammation in Asthma Dale T. Umetsu, MD, PhD Principal Medical Director Genentech The Prince Turki bin Abdul Azis al Saud Professor Harvard Medical School Boston Children