International Symposium of Environmental Medicine
|
|
|
- Lauren Fitzgerald
- 5 years ago
- Views:
Transcription
1 International Symposium of Environmental Medicine
2 Including Asthma, Rhinitis Eczema, Uti Urticaria i (hives) Drug, Food, and Insect allergy Asthma: ~ patients in the world 250,000 asthma deaths occur in the world each year Rhinitis: i i 10% ~ 30 % of the population. Still steady increase in the prevalence ~30% 40% population affected WAO White Book on Allergy : Executive Summary
3 Taiwan Rhinitis = 30 40% Wheezing =10% Allergy 65: , 2010
4 Nat Rev Immunol 2008, 8: 205
5 Nat Med 2012, 18: 673
6 Hypothesis. Environmental EDCs Asthma To set up animal models relevant to human exposure To set up animal models relevant to human exposure To clarify immunological mechanisms of EDC effect
7 Akylphenol ethoxylate (APEs) Nonylphenol ethoxylate (NPE) Octylphenolethoxylate ethoxylate (OPE) Used as non ionic surfactants Industrial, household applications Personal care products NP and OP Detectable in many food products Lipophilic pollutant Long half life (bioaccumulation) Estrogen like activity Binding to estrogen receptors (ERs) or aryl hydrocarbon receptor (AhR) NPE
8 Sample Alkylphenol yp level N (%) * Location Human milk Adipose tissue Ui Urine NP Mean: 4.47±4.31 ng/g 59 (86%) OP Mean: 129± ±1.68 ng/g 59 (31%) NP Median: 57 (10 567) ng/g 20 (100% ) OP Median: 4.5 (nd 8.6) ng/g 20 (23.5%) NP Median: 0.1 (nd 1.6) mg/l 371 (51%) OP Median: 0.3 (nd 0.4) mg/l 2517 (57%) Taiwan Spain USA Mother plasma NP Median: 5.68 (nd 268) ng/g 42 (52.4%) Taiwan Umbilical cord plasma NP Median: 2.95 (nd 100) ng/g 42 (52.4%) Taiwan Tolerable daily intake of NP (Danish Environmental Agency) 5 g/kg B.W./day Suen JL et al. Kaohsiung J Med Sci. 28: S43 8, 2012
9 (Tolerable Daily Intake) Corn oil or NP (5 g/kg BW/day) Day Sensitization OVA in alum i.p. Challenge OVA aerosol BALF Low dose and daily exposure Pre condition of immune systems Pi Priming i event Mild allergic inflammation
10 BALF (cell infiltration) Splenic DC homeostasis
11 Splenic DC function cdc+naïve CD4 + T cell+anti CD3 Th1: IFN γ Th2: IL 4, IL 5, IL 10 NP exposure alter DCs function to favor Th2 differentiation.
12 Nuclear receptor superfamily of transcription factors ligand dependentd bhlh PAS family Cyp1A1 Cyp1B2 Annu Rev Pharmacol Toxicol 2000, 40:519
13 Adaptive responses to environmental changes Modulating estrogen/androgen pathway positively and negatively Exerting both estrogen and androgen related effects Intrinsic i function largely l unknown AhR is critical in controlling mast cell homeostasis. (Zhou YF and Huang SK. Blood 2013;121(16): ) 3204) AhR activity regulated by dietary compounds present in vegetables promotes intestinal immune function. (Cell. 147: 489, 2011)
14 BALF (cell infiltration) Normal AhR Mutant AhR NP exposure disturbs the physiologic function in an AhRdependent manner, leading to the enhanced allergic lung inflammation.
15 Splenic DC function Bone marrow cells NP GM CSF Immature DCs LPS IL 6 Normal AhR (AhR b ) Mutant AhR (AhR d )
16 NP AhR IL 6 in DC ChIP (IL 6 promoter) Western NP exposure disturbs AhR regulated IL 6 expression. NP s effect is lost in AhR d mice
17 IFN α/β IL 10 TNF α Th1 Inflamma on Inflamma on J Allergy Clin Immunol 2012;129:
18 Splenic pdc function Corn oil or NP (5 g/kg BW/day) Day Splenic pdcs
19 Western blotting (Nuclear IRF7) NP exposure may affect the immune regulation through the altered cytokine pattern in pdcs.
20 epithelial cells AhR + DCs IL 6 MHC II CD4 + T TCR Th2 IL 4 IL 5 Eosinophils Allergic inflammation pdcs IFN α/β IL 10 TNF α Th1 Inflamma on Inflammation Suen JL and Huang SK. Allergy Jun;68(6): Hung CH and Suen JL. PLoS One Sep 11;8(9):e73534
21 Used as plasticizer for polyvinyl chloride plastics (PVC) Non covalent bond to PVC Wide distributionib i ~3 million metric tons/year Food is major source for human exposure. Biological half life < 24 hours
22 Maternal urinary BBzP metabolites Early onset eczema in children (EHP, 2012) A prospectivecohort cohort of 407 women child pairs Settled dust DEHP/BBzP concentrations Childhood asthma, eczema, or rhinitis Three case control studies (Sweden 2004, Bulgaria 2008, Taiwan 2012) y Fractional exhaled NO in atopic children A cross sectional study (Am J Respir Crit Care Med Nov 1;186(9):830 7) Children s urinary DEP/BBzP metabolites
23 DEHP maternal exposure Windows of susceptibility Altered epigenetic programming of somatic cells Increased susceptibility to asthma/allergy Transgeneration Development of Immune System Modified from J Steroid Biochem Mol Bio 127: 204, 2011
24 Chronic & low level exposure Prenatal & postnatal exposure DEHP Ingestion F0 Breast F1 10 days feeding TDI: 37 g/kg/day/ / Naïve F2 OVA PND7/14 Endpoint measurement F3
25 The causal relationship between transgenerational DEHP exposureandallergic allergic inflammation DC differentiation or function? Epigenetic mechanism DC differentiation and functional changes DEHP CH3 C G G Altered gene expression persists Abnormal immune system development Allergic inflammation/diseases Human transgenerational study
26 Grant support KMU NHRI NSC Cooperation Cooperation Dr. SK Huang Dr. CH Hung
27 33
Early life nutrition and Inflammation
Early life nutrition and Inflammation Harry J McArdle and Graham Devereux Rowett institute of Nutrition and Health, University of Aberdeen. Aberdeen Royal Infirmary. The process of development Critical
Feed those babies some peanut products!!!
Disclosures Feed those babies some peanut products!!! No relevant disclosures Edward Brooks Case presentation 5 month old male with severe eczema starting at 3 months of age. He was breast fed exclusively
Endocrine Disrupters as Obesogens
Endocrine Disrupters as Obesogens Is the environment making us fat? Bruce Blumberg, Ph.D. Department of Developmental and Cell Biology Department of Pharmaceutical Sciences Developmental Biology Center
Immunology of Asthma. Kenneth J. Goodrum,Ph. Ph.D. Ohio University College of Osteopathic Medicine
Immunology of Asthma Kenneth J. Goodrum,Ph Ph.D. Ohio University College of Osteopathic Medicine Outline Consensus characteristics/incidence data Immune/inflammatory basis Etiology/Genetic basis Hygiene
Allergy and Immunology Review Corner: Chapter 75 of Middleton s Allergy Principles and Practice, 7 th Edition, edited by N. Franklin Adkinson, et al.
Allergy and Immunology Review Corner: Chapter 75 of Middleton s Allergy Principles and Practice, 7 th Edition, edited by N. Franklin Adkinson, et al. Chapter 75: Approach to Infants and Children with Asthma
The importance of early complementary feeding in the development of oral tolerance: Concerns and controversies
The importance of early complementary feeding in the development of oral tolerance: Concerns and controversies Prescott SL, Smith P, Tang M, Palmer DJ, Sinn J, Huntley SJ, Cormack B. Heine RG. Gibson RA,
Perinatal Nutrition. Disclosure Statement. Annual Meeting of the NASPGHAN. Keynote Lecture: Nutrients in the Perinatal Environment: Lessons Learned
Annual Meeting of the NASPGHAN Chicago, ILL October 10-13, 2013 Keynote Lecture: Nutrients in the Perinatal Environment: Lessons Learned Allan Walker, M.D. Boston, MA Disclosure Statement Dr. Allan Walker
Allergy overview. Mike Levin Division of Asthma and Allergy Department of Paediatrics University of Cape Town Red Cross Hospital
Allergy overview Mike Levin Division of Asthma and Allergy Department of Paediatrics University of Cape Town Red Cross Hospital Adaptive Immune Responses Adaptive immune responses allow responses against
Persistent food allergy might present a more challenging situation. Patients with the persistent form of food allergy are likely to have a less
Iride Dello Iacono Food allergy is an increasingly prevalent problem in westernized countries, and there is an unmet medical need for an effective form of therapy. A number of therapeutic strategies are
Triggers Allergens Allografts Helminths Viruses Tissue Injury
Rothenberg et al. Adv Immunol; 2001 Triggers Allergens Allografts Helminths Viruses Tissue Injury Rothenberg et al. Adv Immunol; 2001 Triggers Allergens Allografts Helminths Viruses Tissue Injury Cytotoxic
Allergy in young children
APAPARI TRAINING COURSE Allergy in young children Hugo Van Bever National University Singapore Phnom Penh, 26 May 2007 APAPARI 2005 Seoul, S-Korea APAPARI JACIN MEETING, JAKARTA APRIL 2006 APAPARI - Education
SAB Report to the Board of the Glass Packaging Institute
SAB Report to the Board of the Glass Packaging Institute A Brief Overview of Significant Studies on BPA During 2013 November, 2013 Glass is ENDLESSLY Recyclable Introduction Number and diversity of studies
E-1 Role of IgE and IgE receptors in allergic airway inflammation and remodeling
E-1 Role of IgE and IgE receptors in allergic airway inflammation and remodeling Ruby Pawankar, MD, Ph.D. FRCP, FAAAAI Prof. Div of Allergy, Dept of Pediatrics Nippon Medical School Tokyo, Japan pawankar.ruby@gmail.com
Diet during pregnancy. and atopic disease
Diet during pregnancy and atopic disease 1. Elimination diet 2. Probiotics 3. LCPUFA 4. Conclusions Maternal elimination diet during pregnancy? NO! Prescription of of an an antigen avoidance diet to to
Paediatric Food Allergy. Introduction to the Causes and Management
Paediatric Food Allergy Introduction to the Causes and Management Allergic Reactions in Children Prevalence of atopic disorders in urbanized societies has increased significantly over the past several
Environmental Exposures and Immune Function
Environmental Exposures and Immune Function Presented by Dr. B Paige Lawrence Professor of Environmental Medicine and of Microbiology & Immunology University of Rochester School of Medicine and Dentistry
TITOLO RELAZIONE Vitamina D ed infezioni respiratorie ricorrenti. DOCENTE Prof. Peroni Diego
TITOLO RELAZIONE Vitamina D ed infezioni respiratorie ricorrenti DOCENTE Prof. Peroni Diego Ruolo dell'ipovitaminosi D nelle infezioni respiratorie Diego Peroni U.O. Pediatria Università di Pisa Le basi
Food Allergy in Turkey
Food Allergy in Turkey Isil B Barlan Pediatric Allergy/ Immunology Marmara University Istanbul Brussels/ 07 Age distribution in Turkey over 65 % 65 %5 % 30 0-14 15-64 Median age 50 45 40 35 30 25 20 15
N-3 polyunsaturated fatty acids and allergic disease
N-3 polyunsaturated fatty acids and allergic disease Current Opinion in Clinical Nutrition and Metabolic Care Volume 7(2) March 2004 pp 123-129 Susan Prescott and Philip Calder Abbreviations DHA: EPA:
The Primary Prevention of Asthma
The Primary Prevention of Asthma Risk Factors Associated with Asthma Onset Ted Schettler Science and Environmental Health Network Collaborative on Health and Environment June, 2013 Asthma: a complex disease(s)
Identifying Biologic Targets to Attenuate or Eliminate Asthma Exacerbations
Identifying Biologic Targets to Attenuate or Eliminate Exacerbations exacerbations are a major cause of disease morbidity and costs. For both children and adults, viral respiratory infections are the major
Allergic Disorders. Allergic Disorders. IgE-dependent Release of Inflammatory Mediators. TH1/TH2 Paradigm
Allergic Disorders Anne-Marie Irani, MD Virginia Commonwealth University Allergic Disorders IgE-mediated immune reactions Clinical entities include: asthma allergic rhinitis atopic dermatitis urticaria
Allergic Disorders. Allergic Disorders. IgE-dependent Release of Inflammatory Mediators. TH1/TH2 Paradigm
Allergic Disorders Anne-Marie Irani, MD Virginia Commonwealth University Allergic Disorders IgE-mediated immune reactions Clinical entities include: asthma allergic rhinitis atopic dermatitis urticaria
Gene-Environment Interaction in Allergic Asthma
Gene-Environment Interaction in Allergic Asthma Renz, von Mutius, et al. Nature Immunology 211;12:273-7. Renz H, Autenrieth IB, Brandtzeag P, Cookson WO, Holgate S, von Mutius E, et al. JACI 211;128(6):25-49.
Housing Environment without a Driveway Associated with Early Allergic Symptoms and Allergic Sensitization
2012 International Conference on Environmental, Biomedical and Biotechnology IPCBEE vol.41 (2012) (2012) IACSIT Press, Singapore Housing Environment without a Driveway Associated with Early Allergic Symptoms
Innate immune regulation of T-helper (Th) cell homeostasis in the intestine
Innate immune regulation of T-helper (Th) cell homeostasis in the intestine Masayuki Fukata, MD, Ph.D. Research Scientist II Division of Gastroenterology, Department of Medicine, F. Widjaja Foundation,
Immunology of Asthma. Kenneth J. Goodrum,Ph. Ph.D. Ohio University College of Osteopathic Medicine
Immunology of Asthma Kenneth J. Goodrum,Ph Ph.D. Ohio University College of Osteopathic Medicine Outline! Consensus characteristics! Allergens:role in asthma! Immune/inflammatory basis! Genetic basis!
Multiple Sclerosis and Neuroinflammation: Considering Gender differences to design therapeutic agents HALINA OFFNER
Multiple Sclerosis and Neuroinflammation: Considering Gender differences to design therapeutic agents HALINA OFFNER Sex differences in autoimmune disease Ratio Target Sex distribution of major autoimmune
Essential fatty acids, asthma and allergies in children A summary of epidemiological evidence
Essential fatty acids, asthma and allergies in children A summary of epidemiological evidence Joachim Heinrich heinrich@helmholtz-muenchen.de Helmholtz Zentrum München Institute of Epidemiology I München,
The Link Between Viruses and Asthma
The Link Between Viruses and Asthma CATHERINE KIER, MD Professor of Clinical Pediatrics Division Chief, Pediatric Pulmonary, and Cystic Fibrosis Center Director, Pediatric Sleep Disorders Center SUNY Stony
Anti-IgE: beyond asthma
Anti-IgE: beyond asthma Yehia El-Gamal, MD, PhD, FAAAAI Professor of Pediatrics Pediatric Allergy and Immunology Unit Children s Hospital, Ain Shams University Member, WAO Board of Directors Disclosure
The g c Family of Cytokines Prof. Warren J. Leonard M.D.
The Family of Cytokines Chief, Laboratory of Molecular Immunology Director, Immunology Center National Heart, Lung, and Blood Institute National Institutes of Health Department of Health and Human Services
Endocrine Disruptors (EDs) ENVIRONMENTAL EXPOSURE TO ENDOCRINE DISRUPTORS AND SELECTED METABOLIC MARKERS IN CHILDREN. Polychlorinated Biphenyls (PCBs)
ENVIRONMENTAL EXPOSURE TO ENDOCRINE DISRUPTORS AND SELECTED METABOLIC MARKERS IN CHILDREN Palkovičov ová Ľubica, Patayová Henrieta, Lancz Kinga, Rausová Katarína na, Wimmerová Soňa, Chovancová Jana, Šovčíková
FOOD ALLERGY AND WHEEZING
FOOD ALLERGY AND WHEEZING Jarungchit Ngamphaiboon Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand The pattern of allergy in developed countries has been changing
Implications on therapy. Prof. of Medicine and Allergy Faculty of Medicine, Cairo University
Implications on therapy Dr. Hisham Tarraf MD,FRCP(Edinb.) Prof. of Medicine and Allergy Faculty of Medicine, Cairo University Need for better understanding Global health problem Impact on quality of life
Vitamina D: un ormone multifunzione
Vitamina D: un ormone multifunzione Introduction And Infections Diego Peroni Clinica Pediatrica Universita di Ferrara Food Allergy Asthma Conclusions diego.peroni@unife.it Holick, M. F. J. Clin. Invest.
Allergic rhinitis (Hay fever) Asthma Anaphylaxis Urticaria Atopic dermatitis
Hypersensitivity Disorders Hypersensitivity Disorders Immune Response IgE Disease Example Ragweed hay fever IgG Cytotoxic Immune complex T Cell Hemolytic anemia Serum sickness Poison ivy IgE-mediated Diseases
Effector T Cells and
1 Effector T Cells and Cytokines Andrew Lichtman, MD PhD Brigham and Women's Hospital Harvard Medical School 2 Lecture outline Cytokines Subsets of CD4+ T cells: definitions, functions, development New
Allergen Exposure and Asthma in US Inner-cities
Allergen Exposure and Asthma in US Inner-cities Elizabeth C. Matsui, MD MHS Assistant Professor of Pediatrics Division of Allergy and Immunology Johns Hopkins University May 18, 2006 Pathophysiology of
Pro/Con: Pets Prevent Allergies and Asthma
Slide 1 Pro/Con: Pets Prevent Allergies and Asthma Slide 2 Special thanks to: n Dr. Dennis Ownby n Dr. Matt Perzanowski n Dr. Erica von Mutius and Dr. Charlotte Braun-Fahrlander n Dr. Andy Liu n Colleagues
Eosinophilic Esophagitis (EoE)
Eosinophilic Esophagitis (EoE) 01.06.2016 EoE: immune-mediated disorder food or environmental antigens => Th2 inflammatory response. Key cytokines: IL-4, IL-5, and IL-13 stimulate the production of eotaxin-3
T Cell Effector Mechanisms I: B cell Help & DTH
T Cell Effector Mechanisms I: B cell Help & DTH Ned Braunstein, MD The Major T Cell Subsets p56 lck + T cells γ δ ε ζ ζ p56 lck CD8+ T cells γ δ ε ζ ζ Cα Cβ Vα Vβ CD3 CD8 Cα Cβ Vα Vβ CD3 MHC II peptide
Airway Inflammation in Asthma Chih-Yung Chiu 1,2, Kin-Sun Wong 2 1 Department of Pediatrics, Chang Gung Memorial Hospital, Keelung, Taiwan.
REVIEW ARTICLE Chih-Yung Chiu 1,2, Kin-Sun Wong 2 1 Department of Pediatrics, Chang Gung Memorial Hospital, Keelung, Taiwan. 2 Division of Pediatric Pulmonology, Department of Pediatrics, Chang Gung Memorial
DOHaD: Role of environmental chemical exposures
DOHaD: Role of environmental chemical exposures Linda S. Birnbaum, Ph.D., D.A.B.T., A.T.S. Director, National Institute of Environmental Health Sciences and National Toxicology Program PPTox-IV Boston,
Inflammation in the clinic
Inflammation in the clinic Stephen T. Holgate MRC Clinical Professor of Immunopharmacology ILSI Europe Workshop, Seville, May 14-15 2012 The immune system acts in four general ways to ensure host defence
1. Digestion of foods and absorption of nutrients takes place in stomach and small bowel in only 2-3 h.
1. Digestion of foods and absorption of nutrients takes place in stomach and small bowel in only 2-3 h. 2. The waste is then stored for 2 days in the large bowel. 3. Do modern humans need a large bowel?
HYPERSENSITIVITY REACTIONS D R S H O AI B R AZ A
HYPERSENSITIVITY REACTIONS D R S H O AI B R AZ A HYPERSENSITIVITY REACTIONS Are exaggerated immune response upon antigenic stimulation Individuals who have been previously exposed to an antigen are said
Environmental programming of respiratory allergy in childhood: the applicability of saliva
Environmental programming of respiratory allergy in childhood: the applicability of saliva 10/12/2013 to study the effect of environmental exposures on DNA methylation Dr. Sabine A.S. Langie Flemish Institute
DOHaD ANZ. Rae-Chi HUANG MBBS, PhD, FRACP, DCH. A/Professor Telethon Kids Institute
DOHaD ANZ Rae-Chi HUANG MBBS, PhD, FRACP, DCH Rae-chi.huang@uwa.edu.au A/Professor Telethon Kids Institute The effects of the early environment can last a lifetime Early environment (diet, microbes, toxins,
Fatty acids and allergy a fishy story?
Fatty and allergy a fishy story? JOHAN CARLSSON, Nutritionist / PhD student UNIVERSITY OF GOTHENBURG Sahlgrenska Academy Institute of Biomedicine Department of Infectious Diseases johan.carlsson@microbio.gu.se
TITOLO RELAZIONE Vitamina D e aspetti immunologici. DOCENTE Michele Miraglia del Giudice
TITOLO RELAZIONE Vitamina D e aspetti immunologici DOCENTE Michele Miraglia del Giudice ????? bone skin placenta adrenal glands Vitamin D Receptors (VDR) are present in different tissues intestine kidneys
Supplementary Figure 1. ETBF activate Stat3 in B6 and Min mice colons
Supplementary Figure 1 ETBF activate Stat3 in B6 and Min mice colons a pstat3 controls Pos Neg ETBF 1 2 3 4 b pstat1 pstat2 pstat3 pstat4 pstat5 pstat6 Actin Figure Legend: (a) ETBF induce predominantly
B-cell. Astrocyte SCI SCI. T-cell
RF #2015 P-01 PI: Azizul Haque, PhD Grant Title: Targeting Enolase in Spinal Cord Injury 12-month Technical Progress Report Progress Report (First Six Months): Enolase is one of the most abundantly expressed
Gifu University Graduate School of Medicine, Gifu Asahi University School of Dentistry, Gifu Sakihai Institute, Gifu
2 3 2 3 Chisato NAGATA, Naoyoshi TAKATSUKA, Noriyuki TAKEDA 2 and Hiroyuki SHIMIZU 3 Gifu University Graduate School of Medicine, Gifu 50-94 2 Asahi University School of Dentistry, Gifu 50-0296 3 Sakihai
Immune dysfunction in children with prenatal immunotoxicant exposures
IV Immune dysfunction in children with prenatal immunotoxicant exposures Berit Granum Norwegian Institute of Public Health 27 th October 2014 Developmental Immunology Colourbox Immune system develops extensively
Part III Innate and Adaptive Immune Cells: General Introduction
Innate and Adaptive Immune Cells: General Introduction Iván López-Expósito As an organ specialized in food digestion and nutrient absorption, the intestinal mucosa presents a huge surface area (almost
Regulation of Type 2 Immunity by Basophils Prof. Dr. David Voehringer
Regulation of Type 2 Immunity by Basophils Department of Infection Biology Institute of Clinical Microbiology, Immunology and Hygiene Outline of the presentation The concept of type 2 immunity Basophil
A. Incorrect! It s not correct. Synergism of cytokines refers to two or more cytokines acting together.
Immunology - Problem Drill 11: Cytokine and Cytokine Receptors Question No. 1 of 10 1. A single cytokine can act on several different cell types, which is known as. Question #1 (A) Synergism (B) Pleiotropism
Evolution of asthma from childhood. Carlos Nunes Center of Allergy and Immunology of Algarve, PT
Evolution of asthma from childhood Carlos Nunes Center of Allergy and Immunology of Algarve, PT allergy@mail.telepac.pt Questionnaire data Symptoms occurring once or several times at follow-up (wheeze,
DNA vaccine, peripheral T-cell tolerance modulation 185
Subject Index Airway hyperresponsiveness (AHR) animal models 41 43 asthma inhibition 45 overview 41 mast cell modulation of T-cells 62 64 respiratory tolerance 40, 41 Tregs inhibition role 44 respiratory
ACTIVATION AND EFFECTOR FUNCTIONS OF CELL-MEDIATED IMMUNITY AND NK CELLS. Choompone Sakonwasun, MD (Hons), FRCPT
ACTIVATION AND EFFECTOR FUNCTIONS OF CELL-MEDIATED IMMUNITY AND NK CELLS Choompone Sakonwasun, MD (Hons), FRCPT Types of Adaptive Immunity Types of T Cell-mediated Immune Reactions CTLs = cytotoxic T lymphocytes
Impact of Asthma in the U.S. per Year. Asthma Epidemiology and Pathophysiology. Risk Factors for Asthma. Childhood Asthma Costs of Asthma
American Association for Respiratory Care Asthma Educator Certification Prep Course Asthma Epidemiology and Pathophysiology Robert C. Cohn, MD, FAARC MetroHealth Medical Center Cleveland, OH Impact of
The Skinny of the Immune System
The Skinny of the Immune System Robert Hostoffer, DO, FACOP, FAAP Associate Professor of Pediatrics Case Western Reserve University, Cleveland, Ohio Overview 1. Immune system of the skin 2. Immune Players
Carsten Flohr ISAAC Steering Committee 2011
Carsten Flohr Industrialised countries 20% asthma 20% eczema 30% allergic rhinitis Developing countries less allergy rural-urban gradient big cities similar prevalence levels to industrialised countries
Eat Dirt: Why Cleanliness is Bad for Asthma
Eat Dirt: Why Cleanliness is Bad for Asthma Joel N. Kline MD MSc Professor, Pulmonary Medicine Director: UI Adult Asthma Center Director, Clinical Research ICTS University of Iowa Iowa City, IA 1 Disclosures:
Allergy and Breast Feeding CON (?) Hugo Van Bever Department of Pediatrics NUHS Singapore
Allergy and Breast Feeding CON (?) Hugo Van Bever Department of Pediatrics NUHS Singapore WAC, Cancun, December 2011 As a pediatrician are you crazy? Breast milk is the best! 1. Nutritional 2. Psychological
Abstract. IgE. IgE Th2. x x IL-4 IL-5 IgE CD4 +
D. o ƒf 6,''!" # + % %$ '& ' '' & " k n k x k k k k k x k IgE k x IgE Ò1Ó k Ò2Ó v k x IgE Th2 x } x x IL-4 IL-5 IgE IgE j IFN-γ IgG j j CD4 + { k d «d j B7 w k k x IgE k 1 k Abstract Parental immunization
Distinction and Overlap. Allergy Dpt, 2 nd Pediatric Clinic, University of Athens
Asthma Phenotypes: Distinction and Overlap Nikos Papadopoulos Allergy Dpt, 2 nd Pediatric Clinic, University of Athens Asthma as a syndrome From the Iliad to ADAM 33 and back again Bronchoconstriction,
Airway macrophages in health and disease Tracy Hussell
Prof. Airway Macrophages in Health and Disease Director, Manchester Collaborative Centre for Inflammation Research (MCCIR), Professor of Inflammatory Disease University of Manchester Manchester, M13 9PT
Innate immunity (rapid response) Dendritic cell. Macrophage. Natural killer cell. Complement protein. Neutrophil
1 The immune system The immune response The immune system comprises two arms functioning cooperatively to provide a comprehensive protective response: the innate and the adaptive immune system. The innate
Skin prick testing: Guidelines for GPs
INDEX Summary Offered testing but where Allergens precautions are taken Skin prick testing Other concerns Caution Skin testing is not useful in these following conditions When skin testing is uninterpretable
Objectives. Protein and Allergy. IgE mediated Food Allergy 11/1/2016. Manifestations of Food Allergy to Cow Milk Proteins
Objectives tein and Allergy Kent Woo, MD (USA) Allergy/Immunology Internal Medicine Describe manifestations of cow milk protein allergy Go over the relevant cow milk protein allergens Discuss on what hydrolyzed
Path2220 INTRODUCTION TO HUMAN DISEASE ALLERGY. Dr. Erika Bosio
Path2220 INTRODUCTION TO HUMAN DISEASE ALLERGY Dr. Erika Bosio Research Fellow Centre for Clinical Research in Emergency Medicine, Harry Perkins Institute of Medical Research University of Western Australia
2011 International Conference of Inflammation, Cancer and Metabolic Disorders Program
Friday, November 4 th, 2011 09:00-09:30 Registration 09:30-09:40 Welcome & Opening Remarks Kenneth K. Wu, M.D., Ph.D. Fu-Tong Liu, M.D., Ph.D. Plenary Lecture I Chair: Kenneth K. Wu, M.D., Ph.D. 09:40-10:40
How close are we to predicting allergenicity of new proteins? 13 April 2012, Praha Corinne Herouet-Guicheney, PhD
How close are we to predicting allergenicity of new proteins? 13 April 2012, Praha Corinne Herouet-Guicheney, PhD Agenda/ Content Potential risk and basic principles Current status in developing a model
Current Asthma Therapy: Little Need to Phenotype. Phenotypes of Severe Asthma. Cellular Phenotypes 12/7/2012
Subbasement Membrane Thickness(µm) 12/7/212 Current Asthma Therapy: Little Need to Phenotype Phenotypes of Severe Asthma Most mild and to some degree moderate asthmatics respond well to currently available
Gut Lung Axis Implication of the Gut Microbiota beyond its niche
Gut Lung Axis Implication of the Gut Microbiota beyond its niche Reema Subramanian PhD Candidate (4 th year) Supervisor: Prof. Margaret Ip Department of Microbiology, CUHK Joint Graduate Student Seminar
THINGS CLINICIANS AND CONSUMERS SHOULD QUESTION. Developed by the Australasian Society of Clinical Immunology and Allergy
THINGS CLINICIANS AND CONSUMERS SHOULD QUESTION Developed by the Australasian Society of Clinical Immunology and Allergy 1 Don t use antihistamines to treat anaphylaxis prompt administration of adrenaline
Grup de fisiologia digestiva i adaptacions nutricionals Institut de Nutrició i Seguretat Alimentaria
Grup de fisiologia digestiva i adaptacions nutricionals Institut de Nutrició i Seguretat Alimentaria 1 Outline Weaning and the consequences of stress Animal blood plasma Spray-drying SDP SDP in a model
Adaptive Immunity. Jeffrey K. Actor, Ph.D. MSB 2.214,
Adaptive Immunity Jeffrey K. Actor, Ph.D. MSB 2.214, 500-5344 Lecture Objectives: Understand role of various molecules including cytokines, chemokines, costimulatory and adhesion molecules in the development
IL-17 in health and disease. March 2014 PSO13-C051n
IL-17 in health and disease March 2014 PSO13-C051n Originally Researchers Suggested That IL-12 and IL-4 drove Th Cell Differentiation Naïve CD4 + T cell Question: Which of these cell types is responsible
and its clinical implications
The Immunology of Allergy and its clinical implications By Dr Priya Bowry Sikand MBBS MRCGP DFFP DIC MSc(Allergy) Back to the Basics. Objectives Understand immunological mechanisms behind Type 1 Hypersensitivity
T cell Receptor. Chapter 9. Comparison of TCR αβ T cells
Chapter 9 The αβ TCR is similar in size and structure to an antibody Fab fragment T cell Receptor Kuby Figure 9-3 The αβ T cell receptor - Two chains - α and β - Two domains per chain - constant (C) domain
R. Masekela. Paediatric Pulmonologist and Allergist
R. Masekela Paediatric Pulmonologist and Allergist Outline Definitions i i Biomass fuels Atopy Respiratory tract Environmental tobacco smoke (ETS) Respiratory tract. HIV Atopy Traffic related air pollutants
The Epigenetics of Obesity: Individual, Social, and Environmental Influences. K. J. Claycombe, Ph.D.
The Epigenetics of Obesity: Individual, Social, and Environmental Influences K. J. Claycombe, Ph.D. What can happen to our gene(s) that would cause obesity? Modification via Epigenetic alterations C
Anti-IL-33 (ANB020) Program
Anti-IL-33 (ANB020) Program Phase 2a Peanut Allergy Clinical Trial Interim Data Update March 26 th 2018 NASDAQ: ANAB Safe Harbor Statement This presentation and the accompanying oral presentation contain
% of live splenocytes. STAT5 deletion. (open shapes) % ROSA + % floxed
Supp. Figure 1. a 14 1 1 8 6 spleen cells (x1 6 ) 16 % of live splenocytes 5 4 3 1 % of live splenocytes 8 6 4 b 1 1 c % of CD11c + splenocytes (closed shapes) 8 6 4 8 6 4 % ROSA + (open shapes) % floxed
The HOME Study: A Cincinnati Cohort Examining Health Outcomes & Measures of the Environment
The HOME Study: A Cincinnati Cohort Examining Health Outcomes & Measures of the Environment Kimberly Yolton, PhD Associate Professor Division of General & Community Pediatrics Cincinnati Children s Hospital
The Burden of Foodborne Chemicals
The Burden of Foodborne Chemicals Herman Gibb, Ph.D. Sciences International, Inc. WHO Consultation to Develop a Strategy for Estimating the Global Burden of Foodborne Diseases WHO Headquarters, Geneva
Evaluation of in utero sensitization by screening antigenspecific immunoglobulin E levels in umbilical cord blood
Original paper Evaluation of in utero sensitization by screening antigenspecific immunoglobulin E levels in umbilical cord blood Tamay Gürbüz, Burcu Karakol, Zehra Esra Önal, Yonca Tabak, Çağatay Nuhoğlu,
Differential effects of risk factors on infant wheeze and atopic dermatitis emphasize a different etiology
Differential effects of risk factors on infant wheeze and atopic dermatitis emphasize a different etiology Allan Linneberg, MD, PhD, a Jacob B. Simonsen, MSc, b Janne Petersen, MSc, a Lone G. Stensballe,
Supplementary Figures
Supplementary Figures Supplementary Figure 1. NKT ligand-loaded tumour antigen-presenting B cell- and monocyte-based vaccine induces NKT, NK and CD8 T cell responses. (A) The cytokine profiles of liver
Diet, microbiota and the immune system: A gut feeling about type 1 diabetes. Dr. Eliana Mariño Monash University Melbourne, Australia
Diet, microbiota and the immune system: A gut feeling about type 1 diabetes Dr. Eliana Mariño Monash University Melbourne, Australia Diet, gut microbiota and Western lifestyle diseases Asthma Fatty liver
Jillian M. Ashley-Martin. Submitted in partial fulfilment of the requirements for the degree of Doctor of Philosophy
Prenatal Exposure to Environmental Contaminants and Newborn Immune System Biomarkers by Jillian M. Ashley-Martin Submitted in partial fulfilment of the requirements for the degree of Doctor of Philosophy
Gender Differences in Autoimmune Diseases
//9 Impact of Gender on the Pathogenesis of Crohn s Disease Theresa T. Pizarro Department of Pathology, CWRU Gender Differences in Autoimmune Diseases n Autoimmune diseases affect ~.7-. million people
Professor, of Human Nutrition
ω-3 fatty acids: The Effects during Pregnancy and Breast feeding Antonis Zampelas Professor, of Human Nutrition Director, Laboratory of Food Chemistry and Human Nutrition, Department of Food Science and
TBBPA. 31 August 2014 Green Science Policy Madrid, Spain. National Institutes of Health U.S. Department of Health and Human Services
TBBPA Linda S. Birnbaum, Ph.D., D.A.B.T., A.T.S. Director, National Institute of Environmental Health Sciences and National Toxicology Program Principle Investigator, National Cancer Institute 31 August
12/10/2009. Department of Pathology, Case Western Reserve University. Mucosal Cytokine Network in IBD
Cytokine-Mediated Inflammation in IBD Theresa T. Pizarro Department of Pathology, Case Western Reserve University Mucosal Cytokine Network in IBD Andoh, et al., 2008 1 Interleukin-1 (IL-1) Family Cytokine
Prevention of Food Allergy. From Pre-conception to Early Post- Natal Life
Prevention of Food Allergy From Pre-conception to Early Post- Natal Life Does Atopic Disease Start in Foetal Life? [Jones et al 2000] Foetal cytokines are skewed to the Th2 type of response Suggested that