Using Research to Advocate for Your Child and to Inform Your Decision-Making
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1 Using Research to Advocate for Your Child and to Inform Your Decision-Making David Mandell ScD Paul Turcotte MPH
2 Agenda Why do we care about research? What are the different types of research? How do I find research? How do I evaluate research? Where to get lay friendly syntheses of research How to use research in treatment and education planning Question and Answer
3 Why do we care about research? To describe observations in life and nature Placebo Response in Autism Studies amantadine, King et al., 2001 aripiprazole; Owen et al., 2009 aripiprazole; Owen et al., 2009 atomoxetine; Arnold et al., 2006 divalproex; Hollander et al., 2009 citalopram; King et al., 2009 fluvoxamine; McDougle et al., 1996 methylphenidate; RUPP, 2005 olanzapine; Hollander et al., 2006 Oral IG; Handen et al., 2009 ORG 2766; Buitelaar et al., 1995 risperidone; McDougle et al., 1998 risperidone; Nagaraj et al., 2006 risperidone; Pandina et al., 2006 risperidone; RUPP, 2002 secretin; Carey et al., 2002 secretin; Chez et al., 2000 secretin; Coniglio et al., 2001 secretin; Dunn-Geier et al., 2000 secretin; Sandler et al., 1999 secretin; Spondheim et al., 2002 valproate; Hellings et al., 2005 Bryan King, Number of Individuals
4 What types of research are there? Basic Research Designed to answer a fundamental question Example: biomedical research Applied Research Taking basic research and applying it to everyday life Example: a pilot program Source: OAR
5 How to find research Online Resources: Pubmed ERIC Offline Resources Medical and University Libraries Contact Researchers
6 How to evaluate research
7 Levels of evidence
8 What are the components of a research article? Abstract Background/ Introduction Methods Results Discussion At the top of the article A brief snapshot of the study Provides context to the study What came first? The recipe for the study Design, participants (characteristics and number), procedure The findings were they significant? Figures to demonstrate the findings How the authors interpreted the findings Limitations? Source: OAR
9 Example of research article components
10 What do results mean? Mean Statistically Significant n Average score, result, etc. of all study participants Findings are only meaningful if they are statistically significant**. If the probability that the difference could be due to chance is less than 5% or 1%, depending on the study. Often indicated with an * in the findings tables. The number of study participants Be wary of studies with small n s Source: OAR
11 What do results mean? Tonge B1, Brereton A, Kiomall M, Mackinnon A, Rinehart NJ. A randomised group comparison controlled trial of 'preschoolers with autism': a parent education and skills training intervention for young children with autistic disorder. Autism Feb;18(2):
12 Where to get lay friendly syntheses of research Autism Research Autism Autism Speaks Video Glossary 0.1/autismspeaks/login Autism Science Foundation Scientist Interviews Thinking Person s Guide to Autism National Institute of Mental Health
13 How to use research in treatment and education planning Objective: what is the challenge you re trying to address? Strategy: how does the clinician/educator/parent plan to address to address this objective? What is the evidence for that strategy? how does it compare with the evidence for other strategies? Implementation What training does frontline staff have in this method? Who will train/supervise them? How will their use of the method be monitored? Evaluation What data will be collected with what frequency to determine outcomes? What timeframe is needed to determine effectiveness?
14 Participating in research Rights Advantages disadvantages
15 What are My Rights as a Study Participant? To know why the research is being conducted To understand the potential risks/side effects To know your information will be secure To ask questions at any time and who to ask To know the alternatives to the research study treatments To know you can dis-enroll at anytime To keep a copy of your consent form Source: Harvard School of Public Health
16 What Questions Should I ask Before Being in a Study? How will I benefit from being in this study? Why is this research study being done? What will be done to me? What happens if I don t want to be in the study anymore? How long will the study last? What will be done with my information? Will being in this research study cost me anything? Source: HHS
17 Takeaways from this Session Reading Research Articles Be a discerning reader; not all research is good research Participating in Research Studies Know your rights The discussion section will help unpack the findings Stay up to date on ASD research by visiting OAR and ASAT Ask questions and understand the study thoroughly Research participation can be time consuming but rewarding
18 Q&A PERIOD
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