Ensuring Safety of Anticoagulation Therapy
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1 Ensuring Safety of Anticoagulation Therapy Abha Agrawal, MD, FACP Chief Medical Officer Kings County Hospital Clinical Associate Dean SUNY Downstate College of Medicine Brooklyn, NY NYACP Webinar April
2 CME Disclosure Abha Agrawal has no relationships with any entity producing, marketing, re-selling, or distributing health care goods or services consumed by, or used on, patients.
3 Kings County Hospital Center 650-bed academic tertiary hospital Level-1 1 Trauma Center 26,000 discharges 750,000 clinic visits 130,000 ED visits
4 NYC HHC Largest municipal health system in the country 11 acute care hospitals >100 diagnostic and treatment centers 7,700 beds 23,000 deliveries 227,000 admissions
5 Agenda Risks of anticoagulants Safety strategies Using health IT to improve anticoagulation safety Case study 1: Electronic anticoagulation protocol Case study 2: Root cause analysis of a medication error
6 Balancing the Risk Bleeding Thromboembolism
7 Problem PE remains the commonest preventable cause of hospital deaths. Many at-risk patients don t t receive VTE prophylaxis (Lancet Jun 2008 ENDORSE study): TOTAL: >68,000 patients Surgical 65% at-risk,, medical 42% at-risk Of at-risk patients Surgical 59% received recommended prophylaxis Medical 40% received recommended prophylaxis
8 VTE Occurs Despite Prophylaxis NEJM PROTECT Apr study Critically ill patients 3764 patients 1873 in dalteparin arm 5.1% had DVT despite prophylaxis 1.3% had PE 1873 in UFH arm 5.8% had DVT despite prophylaxis 2.3% had PE
9 Risk of Anticoagulants Disturbing Numbers Ahead!!
10 Medicare OIG study Nov Medicare beneficiaries discharged in Oct %: adverse events Additional 13.5% - temporary harm 44% preventable 1.5% - contributed to their deaths = 15,000 Medicare beneficiaries in a month (based on ~ 1 million in a month)
11 OIG Medicare Study Infections 15% Medications 31% Surgery / Procedures 26% Ongoing Pt Care 28%
12 Medicare OIG Study (Contd.) Medication events 31% = 40 Excessive bleeding - 12 Delirium or change in mental status - 7 Hypoglycemic event 6 Acute renal insufficiency 4 Severe hypotension 4 Respiratory complications 4 Severe allergic reactions - 3
13 OIG Medicare Study 12 deaths 7 Meds Related 5 ACs Other 5 2 blood stream infection 2 aspiration 1 VAP Other 2 Hypoglycemic episodes
14 Drivers
15 Drivers ISMP: 3 of 14 high alert meds are anticoagulants AHRQ 2011: AC safety as 1 of 11 high impact interventions Leapfrog safety objective #18: march 2006 NPSG: 2011: goal: #3 AC included in IHI 5 million lives campaign
16 Joint Commission Sentinel Events Sentinel Events Alert #41: 2008 Anticoagulants: One of the 5 drugs associated with patient safety incidents. MEDMARX database: ,316 anticoagulants related errors reported 60% reached the patient 3% led to harm or death Performance error (e.g. administration is the most common cause of error).
17 Risk of Anticoagulants Hemorrhagic complications IV UFH: <3% Risk increases with increased dosage and age >70 years LMWH: less major bleeding than UFH Thrombolytic therapy increases the risk of major bleeding 1.5 3X in patients receiving AC therapy Chest 2008: ACCP Guidelines
18 Why anticoagulants are high risk meds? Narrow therapeutic range Interaction with many common foods and medications Need frequent and timely lab monitoring Special issues exist in the elderly, including bleeding complications associated with falls Special risks in neonates
19 Why anticoagulants are high risk meds? (contd.) Lack of standardization for the naming, labeling and packaging of anticoagulants creates confusion. Potentially confusing dosing regimens, newer agents. Special risk during transfers and hand- offs.
20 Anticoagulants: Risk Points Lack of critical patient information Ht, wt, allergies missing or dated Lab values PT/PTT/INR missing or didn t see Baseline monitoring Concomitant use of other anticoagulants Renal impairment Transfers and hand-offs
21 Agenda Risks of anticoagulants Safety strategies Using health IT to improve anticoagulation safety Case study 1: Electronic anticoagulation protocol Case study 2: Root cause analysis of a medication error
22 Steps in Medication Process Prescribing 39% CPOE / Decision Support Transcription 12% Dispensing 11% Robots / Pyxis machines Administration 38% Bar-coded med admin Bates, BMJ, 2000 Leape et al. JAMA. 1995
23
24 What s s in a name? Error Adverse Event Bates DW et al. J Gen Intern Med. 1993
25 Medication Errors Sharp End Errors = Active Errors Blunt End Errors = Latent Errors Reason, James. Human Error. Cambridge University Press, 1990
26 Reason s s Swiss Cheese Model
27 Human versus Systems: Complexity
28 I don t t want to make the wrong mistake. Yogi Berra
29 Agenda Risks of anticoagulants Safety strategies Using health IT to improve anticoagulation safety Case study 1: Electronic anticoagulation protocol Case study 2: Root cause analysis of a medication error
30 Case Study 1: Electronic Acute Anticoagulation Therapy Protocol Covers UFH, LMWH and Warfarin Integrated into hospital-wide EHR and CPOE Integrated into bar-cod medication administration module for nurses Used in ED and Inpatient all services Hirsh J et al. Chest June Antithrombotic and thrombolytic therapy. ACCP evidence-based clinical practice guidelines
31 Electronic AC Therapy Protocol Methodology Corporate-wide AC Committee Jan 2007 Representation from multiple hospitals Included MD, RN, Lab, Pharmacy, IT, Project Management Reviewed literature, recommended dosing guidelines, defined design specifications and workflow integration, beta testing. Nov 2007: pilot at Bellevue Hospital Next ~ 18 months: corporate-wide rollout
32 Electronic AC Therapy Protocol Objectives Improving adherence to evidence-based AC guidelines Reducing variations in dosing protocols across HHC Improving safety by providing point-of of-care decision support during ordering process Improving communication between physicians, nurses, and pharmacists
33 Features Dosing recommendations for UFH, LMWH, Warfarin based on evidence-based guidelines Automated ordering of corollary lab orders such as CBC, aptt and platelet count with medication ordering Trend report, built in the order set, summarizing historic anticoagulation medication and pertinent lab ordering from the last 10 calendar days available from the order entry screen
34 Point-of of-care Decision Support No weight alert Weight consideration alert if >72 hr old Baseline lab warning Platelet warning <100 k or >50% drop Creatinine clearance calculation and warning Embedded mandatory HIT question
35 Anticoagulation Order Set
36 UFH Order Set
37 Heparin bolus order
38 Rx / Lab Report
39 Corollary Orders with Heparin
40 UFH Adjustment Dose
41 Decision Support Features
42 Enoxaparin
43 Enoxaparin
44 Fondaparinux order set
45 Fondaparinux
46 Fondaparinux To order fondaparinux, patient must have a cr clearance of >= 30 ml/min, determined from the most recent weight and serum creatinine results. If any of these three are missing or not recent, enter or order the appropriate values.
47 Coumadin
48 Warfarin Nomogram
49 Warfarin Nomogram: : Patient s s INR is 1.2
50 Select therapy day
51 Day 5 of the Nomogram
52 Day 6 of the Nomogram
53 Case Study 2: Medication Error 74 year old man with multisystem illness in MICU develops PE. Started on heparin infusion develops Heparin- induced thrombocytopenia Prescribed correct weight-based dose of Argatroban. Pharmacist dispenses correct IV mixed bag Nurse mistakenly infuses 20X greater dose of the medication. Patient dies of bleeding complications within 12 hours.
54 Argatroban Order
55 Label on the IV bag
56 Kǘbler-Ross Stages: Medication Safety I - Denial II - Anger The data are wrong The data are right, but it s not a problem III - Bargaining The data are right; it s a problem, but it s not my problem IV - Depression It s my problem, but there is nothing I can do about it V - Acceptance I accept the burden of improvement Adapted from Donald Berwick, MD, IHI 2004 Frontiers of Healthcare conference
57 Knowing is not enough; we must apply. Willing is not enough; we must do. Johann Wolfgang von Goethe.
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