Vaccines, Autism, and Blue Marble Health
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1 Vaccines, Autism, and Blue Marble Health Peter Hotez, M.D., Ph.D. Texas Children s Hospital Endowed Chair in Tropical Dean, National School of Tropical Medicine at Baylor College of Medicine US Science Envoy
2 Houston, Texas Page 2 xxx00.#####.ppt 9/21/2017 4:12:50 PM
3 Global health & disease in the 2020s Page 3 xxx00.#####.ppt 9/21/2017 4:12:50 PM
4 New World Order The term "new world order" has been used to refer to any new period of history evidencing a dramatic change in world political thought and the balance of power. Post WWI League of Nations Post WWII United Nations Cold War Current New World Order Anti-science Regional Conflicts Climate Change US/UK Retreat from Globalization, China s neo-silk Road, & Blue Marble Health Page 4 xxx00.#####.ppt 9/21/2017 4:12:51 PM
5 Page 5 xxx00.#####.ppt 9/21/2017 4:12:51 PM
6 The Global Burden of Disease Expanded use of vaccines 83% reduction in measles deaths 82% reduction in tetanus deaths 57% reduction in diphtheria/pertussis deaths 45% reduction in Hib deaths Development new vaccines Pneumococcal disease (36% reduction in deaths) Rotavirus (63% reduction in deaths) 2.5 million childhood lives saved through these initiatives Page 6 xxx00.#####.ppt 9/21/2017 4:12:51 PM
7 Page 7 xxx00.#####.ppt 9/21/2017 4:12:51 PM
8 Page 8 xxx00.#####.ppt 9/21/2017 4:12:52 PM
9 Personal belief exemptions and Texas Page 9 xxx00.#####.ppt 9/21/2017 4:12:52 PM
10 Texas ranks at the bottom of fully immunized children 45,000 Personal Belief Exemptions in Texas Page 10 xxx00.#####.ppt 9/21/2017 4:12:52 PM
11 Page 11 xxx00.#####.ppt 9/21/2017 4:12:52 PM
12 Measles outbreak Twin Cities MN Page 12 xxx00.#####.ppt 9/21/2017 4:12:52 PM
13 Nation of Islam and Antivaccine Page 13 xxx00.#####.ppt 9/21/2017 4:12:53 PM
14 Is Vaccine Hesitancy Expanding Nationally? Page 14 xxx00.#####.ppt 9/21/2017 4:12:53 PM
15 State Vaccine Exemptions Page 15 xxx00.#####.ppt 9/21/2017 4:12:53 PM
16 Page 16 xxx00.#####.ppt 9/21/2017 4:12:54 PM
17 Page 17 xxx00.#####.ppt 9/21/2017 4:12:54 PM
18 Page 18 xxx00.#####.ppt 9/21/2017 4:12:54 PM
19 The Neurobiology of Autism Page 19 xxx00.#####.ppt 9/21/2017 4:12:54 PM
20 Globalization of Vaccine Hesitancy Page 20 Larson H et al EBioMedicine , DOI: ( /j.ebiom ) xxx00.#####.ppt 9/21/2017 4:12:54 PM
21 How the Anti-Vaxxers are Winning Page 21 xxx00.#####.ppt 9/21/2017 4:12:54 PM
22 Page 22 xxx00.#####.ppt 9/21/2017 4:12:55 PM
23 New survey findings: ResearchAmerica Page 23 xxx00.#####.ppt 9/21/2017 4:12:55 PM
24 New Vaccines for 21 st Century Neglected diseases Page 24 xxx00.#####.ppt 9/21/2017 4:12:55 PM
25 Texas Children s Hospital Center for Vaccine Development 2000 to 2004 Built structure Launched Hookworm Program 2004 to 2011 Expanded Hookworm Program Schisto Program Relocated to TMC 2011 to 2015 Added 7 additional programs Expansion of capabilities Page 25 xxx00.#####.ppt 9/21/2017 4:12:55 PM
26 Rino Rappuoli: Reverse Vaccinology Page 26 xxx00.#####.ppt 9/21/2017 4:12:56 PM
27 Reverse vaccinology as a holy grail for complex eukaryotic organisms Large genomes of similar complexity to human genome Inadequacy of bacterial expression systems for eukaryotic antigens Low throughput not high throughput Deficiencies in animal models Page 27 xxx00.#####.ppt 9/21/2017 4:12:56 PM
28 Vaccine Targeting Hookworm and Schistosomiasis Co-Infections A MULTIVALENT VACCINE TARGETING HOOKWORM + SCHISTO W/F/Y P C C EC-2 EC-1 G C C E/Q C G C membrane G/A G/A E/Q G/A E/Q G/A F/Y K Page 28 xxx00.#####.ppt 9/21/2017 4:12:56 PM
29 Three Major Drivers of 21 st Century NTDs Health system collapse Conflict Poverty Blue Marble Health Poverty Conflict Climate Page 29 xxx00.#####.ppt 9/21/2017 4:12:56 PM
30 BLUE MARBLE HEALTH: The Poor Living Among the Wealthy (G20 + Nigeria) WHO + GBD % Leprosy 61-78% Chagas 60-61% Dengue 57-60% TB 45-67% VL 50-52% Helminths G20 + Nigeria = 54% Population and 86% Global Economy STH Schistosomiasis Lymphatic Filariasis Onchocerciasis Page 30 xxx00.#####.ppt 9/21/2017 4:12:57 PM
31 US Gulf Coast: America s Underbelly NTDs Toxocariasis 2.2 M Trichomoniasis 1.4 M Chagas disease 58,000 WNV 8,365 Typhus 1,762 Leprosy Dengue, Zika, chik Cysticercosis 21 st Century Forces Poverty Climate Change Urbanization Human migrations Transportation Page 31 xxx00.#####.ppt 9/21/2017 4:12:57 PM
32 Therapeutic Chagas Disease Vaccine Increased Ag-specific IFNγ Decreased T. cruzi burden Decreased Cardiac fibrosis Experimental Chagas disease vaccine improves Cardiac Echocardiography function Page 32 xxx00.#####.ppt 9/21/2017 4:12:57 PM
33 CONFLICT & POLITICAL DESTABILIZATION: ISIS-occupied Syria, Iraq, Libya, Yemen Measles/Polio Leishmaniasis Schistosomiasis Brucellosis MERS CoV Dengue and RVF Malaria/TB Cholera Page 33 xxx00.#####.ppt 9/21/2017 4:12:58 PM
34 Bivalent recombinant vaccine NH36 Sandfly antigens: LJM19 LJM143 GLA or CpG Leishmaniasis Vaccine Page 34 xxx00.#####.ppt 9/21/2017 4:12:58 PM
35 Coronaviruses MERS-CoV SARS-CoV Coronavirus 3 groups of coronaviruses. MERS-CoV is the 6th new type of coronavirus like SARS-CoV. SARS-CoV and MERS-CoV are β coronaviruses. MERS-CoV was first identified in 2012, and causes increased cases of infections in humans and camels. MERS-CoV Page 35 xxx00.#####.ppt 9/21/2017 4:12:59 PM
36 U.S. Science Envoy Program Page 36 xxx00.#####.ppt 9/21/2017 4:12:59 PM
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