VISION. for a world free from infectious and neglected diseases

Transcription

1 VISION for a world free from infectious and neglected diseases Annual Report 2015

2 Our Mission is to reduce needless human suffering from vaccine-preventable and neglected tropical diseases (NTDs) by developing new vaccines, advocating increased use of existing vaccines and promoting expanded access to affordable medical treatments.

3 Table of Contents 2 Leadership 3 Letter from the Chairman and the CEO 4 Vaccine Development 10 Vaccine Advocacy and Education 18 Global Network 24 Sabin Foundation Europe 26 Awards and Recognition 27 Finances 1

4 Leadership Axel Hoos, M.D., Ph.D. Chairman, Sabin Vaccine Institute; Senior Vice President, Oncology R&D, GlaxoSmithKline Pharmaceuticals Amy Finan Chief Executive Officer Peter J. Hotez, M.D., Ph.D. President, Sabin Vaccine Institute; Director, Sabin PDP, Sabin Vaccine Institute and Texas Children s Hospital Center for Vaccine Development at Baylor College of Medicine Jon Andrus, M.D. Executive Vice President, Sabin Vaccine Institute; Director, Vaccine Advocacy and Education Brian Davis, C.P.A. Chief Operating Officer 2

5 Charting our Future Letter from the Chairman and the CEO It is an honor for us to lead and serve the Sabin Vaccine Institute as Chairman and CEO. For 22 years, this organization has fought tirelessly to improve health for marginalized communities around the world by strengthening immunization programs, improving access to basic medical treatments and advancing novel vaccines to prevent infectious and neglected tropical diseases (NTDs). Sabin continues to embody the indefatigable drive for progress of our namesake, Dr. Albert B. Sabin, inventor of the oral polio vaccine and lifelong crusader against poverty and preventable disease. Even as we celebrate the near success of the decades-long effort to eradicate polio, we face threats both new and familiar Zika, the resurgence of dengue and measles, which continues to be one of the leading causes of death among young children. Sabin s mission is as important as ever. Despite tremendous progress, 20 percent of children miss out on routine vaccines, more than a billion people suffer from NTDs, and we have learned just how vulnerable we are to unforeseen disease outbreaks. To meet these challenges will require a concerted effort to develop new vaccines, build capacity to introduce vaccines, encourage country ownership of immunization programs, and improve not only immunization rates but also access to data for informed decision making. Through education and training, advocacy and vaccine development, Sabin advances solutions to some of the world s most prevalent health problems. Sabin acts as a catalyst, a champion and a coalescing force to focus the use of immunization science in the service of people everywhere. In 2015, years of effort by Sabin bore striking results. Sabin s collaboration with the governments of Nepal and Uganda helped these countries take strong steps toward country ownership through legislation, as both countries passed laws to establish and protect domestic funding for immunization. The International Association of Immunization Managers held its first global conference, attended by immunization managers from more than 70 countries. Sabin completed a dengue surveillance project in 2015 with the Pan American Health Organization and is providing the information countries need to make informed decisions regarding new dengue vaccines. Sabin also advanced our vaccine candidates, including initiating clinical trials for a vaccine candidate to prevent schistosomiasis, the second most common parasitic disease after malaria and the deadliest of the most common NTDs saw significant global policy wins, with commitments from the G7 and BRICS countries to invest in NTDs. We thank Ambassador Michael Marine for his leadership as CEO over the past six years and look forward to his ongoing guidance as a member of Sabin s board of trustees. We are excited to define Sabin s next chapter, guided by the principles of equity, sustainability and country ownership. Through the passion of our dedicated team, the board and our partners, Sabin will continue to lead the way toward a healthier future Morton P. Hyman Chairman Michael W. Marine, Ambassador (Ret.) CEO Peter J. Hotez, M.D., Ph.D. President 3

6 4 VACCINE DEVELOPMENT Developing safe, low-cost vaccines

7 Vaccine Development NTDs affect an estimated one-sixth of the world s population, but these diseases do not receive nearly their share of investments in research and development. The Sabin PDP translates scientific research into life-saving products to prevent NTDs and emerging viral infections. For more than 15 years, the Sabin Vaccine Institute Product Development Partnership (Sabin PDP) has pioneered the development and testing of low-cost vaccines to prevent and treat NTDs and emerging viral infections. Because NTDs overwhelmingly affect people living in poverty, this research is typically overlooked by pharmaceutical companies. In partnership with academic institutions, non-profit organizations and governmental agencies around the globe, the Sabin PDP has built a platform to develop and test vaccine candidates and advance them through early product and clinical development. The Sabin PDP is conducting vaccine research and development for hookworm, schistosomiasis, leishmaniasis, Chagas disease, trichuriasis (whipworm), ascariasis (roundworm), onchocerciasis (river blindness), West Nile virus, severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). As vaccine candidates for hookworm and schistosomiasis advance through clinical trials, the Sabin PDP is evaluating opportunities to partner with developing country vaccine manufacturers for the eventual scale up of production for NTD vaccines and build the case for investment in these products. 5

8 Vaccine Development Building Global Research Expertise Sabin is helping low- and middleincome countries establish vaccine development capacity to respond to the burden of NTDs and prevent future disease outbreaks. Peter Hotez, MD, PhD, is president of Sabin and director of the Sabin PDP. WHAT'S NEXT The Sabin PDP will train counterparts from King Saud University in vaccine development at its headquarters at the Texas Medical Center in Houston, Texas, in partnership with Texas Children s Hospital and Baylor College of Medicine. Less than a year after the Ebola crisis, the spread of Zika once again exposed the critical need for increased vaccine research and development capacity around the world. To prevent and control future outbreaks, Sabin is committed to advancing global capacity for vaccine research and development. In his role as U.S. Science Envoy, Sabin s President, Dr. Peter Hotez, is bringing attention to the growing threat of disease in the Middle East and North Africa due to conflict and post-conflict conditions. To build capacity for vaccine research in the region, Sabin is partnering with King Saud University in Saudi Arabia, leveraging a training model established with the University of Malaya in Malaysia. 6

9 Vaccine Development Preventing Snail Fever Schistosomiasis is a parasitic disease carried by freshwater snails, which infects people in as many as 78 countries, with the vast majority of the burden in Africa. In 2015, the Sabin PDP began the first clinical trial in humans for a vaccine candidate to prevent schistosomiasis also known as snail fever which infects more than 250 million people worldwide and kills an estimated 280,000 people each year in Africa alone. Schistosomiasis is the second most common parasitic disease after malaria and the deadliest of the most common NTDs. WHAT'S NEXT The Sabin PDP plans to test the vaccine in schistosomiasis-endemic areas of South America and Africa. The Sabin PDP is developing a business case for the schistosomiasis vaccine that will address the global need for the vaccine; the process of research, development and commercialization; financial modeling; and a funding strategy. 7

10 Vaccine Development Protecting Against Hookworm Hookworm infection is both a symptom and a source of poverty. Infecting nearly half a billion people worldwide, it is a major cause of malnutrition and anemia in pregnant women and children. Dr. Maria Elena Bottazzi is Deputy Director of the Sabin PDP, based in the Texas Medical Center in Houston, Texas, at Texas Children s Hospital and Baylor College of Medicine. WHAT'S NEXT The Human Hookworm Vaccine will be evaluated for its safety and immune response in healthy adults and children in Brazil and Gabon. In 2015, the Sabin PDP completed clinical trials in Washington, D.C. and Brazil for its most advanced product, the Human Hookworm Vaccine. These trials evaluated safety and immune response for two promising vaccine candidates to prevent human hookworm infection, which infects one-quarter to one-third of all pregnant women in Africa and can lead to serious health risks during pregnancy and childbirth. Additional clinical trials are ongoing in the United States, as well as in hookworm-endemic areas in Gabon and Brazil. The successful completion of these trials would be a significant step toward the first vaccine specifically targeting iron-deficiency anemia in low- and middle-income countries, where hookworm infection is widespread. 8

11 Vaccine Development Disease Prevalence SCHISTOSOMIASIS HUMAN HOOKWORM SOIL-TRANSMITTED HELMINTHS CHAGAS DISEASE CUTANEOUS LEISHMANIASIS ONCHOCERCIASIS WEST NILE DISEASE SARS AND MERS 9

12 10 VACCINE ADVOCACY AND EDUCATION Expanding access to vaccines

13 Vaccine Advocacy and Education Successful immunization programs require much more than just vaccines. Sabin works to improve the delivery, technical capacity and financing of national immunization programs around the world. One in five children does not receive basic immunizations. Guided by the principles of equity, sustainability and country ownership, Sabin s Vaccine Advocacy and Education programs seek to extend the benefit of immunization to everyone. Sabin brings together national governments, policy makers, immunization specialists, researchers and advocates to strengthen immunization programs and achieve the 2020 goals set by the Global Vaccine Action Plan. New vaccines can take years to reach low-income countries. Sabin works to accelerate access to lifesaving vaccines for those most at risk, advocating for effective vaccines and better data for decision making, conducting research, training immunization professionals and working with countries to expand and protect their immunization budgets. 11

14 Vaccine Advocacy and Education Fighting Typhoid Together The Coalition against Typhoid (CaT) works to prevent typhoid through research, education and advocacy. 200,000 the number of people that die every year from typhoid fever. 27 countries have reported drugresistant strains of typhoid fever. WHAT'S NEXT CaT will implement new activities in 2016, such as convening leaders to share best practices and providing advocacy training and resources to typhoid leaders in Africa and Asia. CaT will continue working on typhoid surveillance in Bangladesh, India, Nepal and Pakistan to determine the burden of disease in these countries. Typhoid fever, an infection spread through contaminated food and water, kills more than 200,000 people every year, most of whom are children. CaT engages stakeholders to support solutions for typhoid and related diseases, including vaccines and clean water. In 2015, CaT convened more than 200 researchers, policy makers and representatives from international organizations from 43 countries at its ninth international conference in Indonesia. The conference highlighted the spread of drug-resistant typhoid across Africa and Asia, underscoring the urgent need to introduce new vaccines to protect young children and other at-risk populations. CaT launched a new strategy to increase advocacy activities and expand coalition membership to additional health sectors including water, sanitation and hygiene. A leader in research, CaT initiated the second phase of its Surveillance for Enteric Fever in Asia Project (SEAP) in SEAP is one of the few studies to characterize the complications and severity of typhoid in addition to disease burden, which will assist countries in making decisions regarding vaccine implementation. 12

15 Vaccine Advocacy and Education Fostering Country Ownership of Immunization Programs The Sustainable Immunization Financing (SIF) program works alongside government officials in Europe, Africa and Asia to achieve country ownership of immunization through domestic immunization financing. As low- and middle-income countries grow their economies, they become ineligible for the donor funding that had supported many of their immunization programs. These countries are now developing long-term, domestic financing solutions to support immunization. SIF works with health and finance officials in these countries as they navigate this transition. Photo: Hon. A.B.D. Sesay, parliamentarian from Sierra Leone, speaks at 2015 peer review workshop. Following a 2015 workshop, three countries secured substantial budget increases for immunization. and Africa. Approved Government Routine Immunization Budgets SIF is supporting 16 of its partner countries in legislative projects. In 2015, SIF played a vital role in the passage of immunization legislation in Uganda and Nepal, providing briefings on novel financing approaches and bringing parliamentarians together with ministry officials to draft and advance legislation. SIF provides country officials with tools to analyze budgets and advocate for increased government immunization spending. During a 2015 SIF workshop, representatives from Mali, Senegal and Cameroon prepared evidence-based investment cases and practiced advocating for increased immunization budgets. Within six months, all three countries secured budget increases. Sources: Ministry of Health Reports to Sabin SIF field officers. WHAT'S NEXT In 2016, SIF is hosting four regional workshops and its third international colloquium, which will bring together counterparts from each of SIF s partner countries to exchange ideas and share news regarding their progress on immunization financing. 13

16 Vaccine Advocacy and Education Improving Immunization Programs through Management Training The International Association of Immunization Managers (IAIM) is the only international professional association dedicated to immunization managers, offering opportunities to connect, share knowledge and strengthen management and leadership skills in order to advance immunization program performance. WHAT'S NEXT IAIM will host a regional meeting in China for its members from Asia and the Pacific in A key theme will be the elimination of measles and rubella as an opportunity to strengthen health systems and promote global health security. Photo: Theresia Sandra Diah Ratih, IAIM member from Indonesia, at the 2015 global conference. IAIM helps members from more than 100 countries prepare for the future by investing in management skills to advance their immunization programs. Better performing programs will be required not only to extend the benefits of life-saving vaccines to the 20 percent of children who do not currently receive them, but also to introduce a new generation of vaccines targeting older children and adults was a year of firsts for IAIM, which held its first global conference, attended by members from more than 70 countries, and empowered IAIM members to take ownership of the association, electing their own governing council for the first time. IAIM launched its Training Scholarship Program in 2015, facilitating journeys across the country or around the world for its members to participate in valuable training programs. IAIM also grew its membership in 2015, particularly in Francophone countries. 14

17 Vaccine Advocacy and Education Training Scholarships & Peer-to-Peer Exchanges IAIM members from 19 countries have participated in Training Scholarships and Peer-to-Peer Exchanges since IAIM's launch in Peer-to-Peer Training Scholarships 15

18 Vaccine Advocacy and Education Special Projects Sabin helps endemic countries make informed decisions about introducing new and underutilized vaccines. LEADERSHIP IN DENGUE PREVENTION Sabin and the Pan American Health Organization (PAHO) completed the Dengue Surveillance Project in 2015, which created a disease surveillance model to help countries in Latin America and the Caribbean make decisions regarding new dengue vaccines. Sabin also hosted the First Regional Dengue Symposium in Brazil, where attendees from 16 countries learned about new research that will inform decisions on dengue vaccine introduction in endemic countries. CIRO DE QUADROS VACCINOLOGY COURSE Since 2011, Sabin s vaccinology course has trained more than 175 delegates from Latin America and Caribbean on the fundamentals of epidemiology and immunology, current immunization recommendations, funding mechanisms, effective communication, and challenges facing immunization programs. At this year s course, more than 40 participants were introduced to an entirely new curriculum, which will be the basis of a bilingual vaccinology textbook. 16

19 Vaccine Advocacy and Education PROVAC INTERNATIONAL WORKING GROUP Sabin partners with PAHO on the ProVac Initiative, which works with developing countries to strengthen their ability to make data-driven decisions on vaccine introduction. In 2015, Sabin designed a strategy to implement the ProVac methodology in countries engaged in Sabin s Sustainable Immunization Financing Program, to provide guidance as these countries carry out their own studies to assess the cost-effectiveness of introducing new vaccines. CONVENING THOUGHT LEADERS Over the past five years, Sabin has brought together more than 2,000 attendees from nearly 100 countries at more than 20 meetings. In 2015 alone, Sabin convened attendees from more than 25 countries at conferences and meetings concerning the status of the global measles control program, research on rubella, surveillance strategies for meningococcal disease, and more. WHAT'S NEXT Sabin looks to expand its work into monitoring and evaluation while continuing to develop evidence to ensure vaccines and immunization strategies are saving more lives more quickly. 17

20 18 GLOBAL NETWORK Putting the spotlight on neglected tropical diseases

21 Global Network Neglected tropical diseases (NTDs) impact more than a billion people around the world, yet they receive scant political or public attention, and programs to prevent and control these devastating diseases are chronically underfunded. NTDs are inextricably linked to poverty. They impact vulnerable populations, causing disfigurement and disability, and leading to physical and developmental delays in children. Many of these diseases can be treated with medicine donated by pharmaceutical companies; it s just a matter of getting these drugs to the people who need them. In fact, it costs less than 50 cents per year to protect one person against the most common NTDs. Sounds simple, right? But more than 800 million children are still at risk of contracting one or more NTD. Through the work of the Global Network, Sabin has been a leading advocacy organization for NTDs, dedicated to raising the awareness, political will and funding required to eliminate these diseases as a public health threat to the world s poorest communities. Sabin works to achieve this by cultivating advocates at every level from college students to parliamentarians to get NTDs onto national, regional and international development agendas. We also work with in-country partners to improve the success of NTD prevention and treatment programs. For example, the Global Network coordinated with the Indian government and partners in 2015 to arrange a site visit for Indian journalists to learn about lymphatic filariasis (also known as elephantiasis). The journalists interviewed people living with lymphatic filariasis to understand the challenges they face in the rural, remote villages where they live. This resulted in more than a dozen unique media pieces in four languages, encouraging participation in nationwide drug distribution programs. 19

22 Global Network NTDs on the Global Stage The Global Network contributed to significant global policy victories in 2015, unifying partners to secure a place for NTDs on the global development agenda. Photo: NTD Special Envoy Dr. Mirta Roses met with Professor Keizo Takemi, member of Japan's legislature, to urge Japan to prioritize NTDs on the G7 agenda. With relatively little material effort, the suffering of hundreds of millions of people could be combatted. German Chancellor Angela Merkel, on the subject of NTDs, World Health Assembly Opening Address WHAT'S NEXT Sabin is working to persuade global policy makers to translate their commitments to fight NTDs into concrete initiatives, advancing efforts to achieve NTD-related targets in the SDGs and improving health outcomes for people around the world. Leading up to the 2015 G7 Summit, the Global Network facilitated the first-ever NTD community letter to G7 Heads of State. This letter, which brought together more than 100 signatories, was a key component of Sabin s strategy to ensure a robust, concrete outcome for NTDs. Prior to the Summit, the Global Network and the German NTD Network also raised awareness within Germany of the pressing need for greater access to NTD treatments and the resource gaps for neglected diseases. These efforts came to fruition at the 2015 Summit, where member countries renewed commitments to fight NTDs, pledging to invest in prevention, treatment and research. Other countries play a vital role in NTD control and elimination. In 2015, the Global Network urged officials from BRICS countries Brazil, Russia, India, China and South Africa to renew their commitments to combatting NTDs. BRICS leaders incorporated the fight against NTDs into two separate declarations in 2015, demonstrating their commitment to relieving suffering for those in need. Following a successful two-year effort to secure a place for NTDs in the Sustainable Development Goals (SDGs), the Global Network fought for the inclusion of an indicator to measure progress against NTDs. After months of advocacy, the indicator received a green light in late

23 Global Network Mobilizing the Next Generation of Advocates Through END7, the Global Network is inspiring and educating a new generation of global health professionals to combat NTDs. END7, an international advocacy campaign led by Sabin, engages the public to raise awareness of NTDs and urge world leaders to prioritize these diseases of poverty. In 2015, thousands of people around the world joined END7 s advocacy campaign to the UN, asking their ambassadors to support an NTD indicator in the SDGs. Thousands more Americans wrote to their Members of Congress and President to ask that they protect NTD funding. In 2015, END7 s student outreach program grew to include young leaders at more than 50 universities in 15 countries. Students published op-eds and research papers, led creative advocacy campaigns, and engaged in education and fundraising on university campuses from Scotland to Sierra Leone. To date, END7 students have raised more than $100,000 for NTD treatment programs. END7 held its first Student Advocacy Day in 2015, bringing 20 students to Washington, D.C., for nearly two dozen meetings with Members of Congress and their staff, urging them to maintain and grow USAID funding for NTDs. This event grew in 2016, with 40 students from 15 universities participating in 39 meetings with key congressional offices. The day concluded with a keynote address from Barbara Bush, co-founder and CEO of Global Health Corps and daughter of President George W. Bush. WHAT'S NEXT END7 will continue to advocate for increased U.S. support of NTD treatment programs. This year, the campaign is approaching $1 million in donations to help deliver medications and support treatment programs. 21

24 Global Network Making NTDs a Priority The Global Network cultivates support for NTD treatment from key governments and influencers. Sabin works closely with stakeholders at the Vatican, resulting in highprofile public statements on NTDs, including a 2015 speech in which Pope Francis included NTDs in a list of health issues requiring urgent political attention. WHAT'S NEXT Sabin will serve as an official planning partner for the November 2016 International Conference of the Pontifical Council for Health Care Workers at the Vatican on Diseases of Solidarity both rare and neglected tropical diseases. Through regular engagement with members of the U.S. Congress, the Global Network and its END7 campaign helped protect the USAID NTD budget against proposed cuts in With leadership from Sabin s U.K.-based sister organization, Sabin Foundation Europe, advocacy by the Global Network contributed to the inclusion of NTDs in the 1 billion Ross Fund to fight malaria and NTDs, launched by the U.K. Government in As two key international donors to global NTD treatment programs, the Global Network pushed the U.S. and U.K. Governments to continue championing NTDs and encouraged other governments to join the global fight against NTDs, emphasizing the vital importance of increasing resources in order to reach control and elimination goals. 22

25 Global Network Building Global Awareness The END7 campaign s How to Shock a Celebrity video, featuring celebrities including Eddie Redmayne, Priyanka Chopra and Emily Blunt, reached 7 million views in The Global Network advocated for an increased NTD budget on the Hill through testimonies, community letters, petitions and personal engagement with Members of Congress. Photo: Sabin President Dr. Peter Hotez testifies before the U.S. House Subcommittee on Africa, Global Health, Global Human Rights and International Organizations on the threat of NTDs. 23

26 24 SABIN FOUNDATION EUROPE Promoting proven solutions to the world s most pervasive health issues

27 Sabin Foundation Europe Sabin Foundation Europe is Sabin s sister organization based in the U.K., supporting the fight against vaccinepreventable and neglected tropical diseases through efforts across Europe. Sabin Foundation Europe is a U.K.-registered charity founded in 2011 to support vaccine research and development, advocacy efforts and treatment programs for vaccine-preventable and neglected tropical diseases (NTDs). Sabin Foundation Europe collaborates with global health partners and coalitions to influence U.K. Government policy on neglected health issues by engaging key decision and policy makers. Sabin Foundation Europe was elected in 2015 to chair the advocacy group for the U.K. Coalition against NTDs, a group of U.K.-based NTD researchers, implementers and advocates committed to raising awareness, influencing U.K. Government policy decisions and getting NTD control on the national, regional and international development agendas. In 2015, funds raised by the Foundation supported programs to prevent and control lymphatic filariasis and soil-transmitted helminths in Guyana and India, in partnership with Sabin City Group and the END7 campaign. Sabin Foundation Europe was also named the official charity partner of the Thomson Reuters Capital Conference, a banking conference in the heart of London s financial district, where the Foundation was able to introduce the issue of NTDs to a private-sector audience and cultivate new champions. WHAT'S NEXT Sabin Foundation Europe will co-author an annual parliamentary NTD report to be launched in 2016 and will forge partnerships in the U.K. to advance Sabin s mission to end preventable diseases, targeting U.K. decision and policy makers. 25

28 Awards & Recognition Awards & Recognition Ambassador Michael W. Marine retired from his role as Sabin s CEO in April 2016 after helming the organization for six years. We thank Ambassador Marine for his leadership, under which Sabin expanded its advocacy programs for vaccinepreventable diseases and NTDs, grew its vaccine development program through a partnership with Texas Children s Hospital and Baylor College of Medicine, and launched END7, the world s largest grassroots advocacy campaign supporting NTD control and elimination programs. Ambassador Marine will continue to serve Sabin s mission on the Board of Trustees. Sabin awarded its 2015 Albert B. Sabin Gold Medal Award to Dr. Roger I. Glass for his pioneering role in research and vaccine development for rotavirus. Rotavirus vaccines, including several that he has helped to develop, are now in use in more than 70 national immunization programs, and have had a major impact in reducing both deaths and diarrheal hospitalizations, improving the health of millions of children worldwide. In 2015, Sabin s President, Dr. Peter Hotez, served as U.S. Science Envoy for the White House and the U.S. Department of State. In this role, Dr. Hotez has worked with the international scientific community to stimulate increased scientific cooperation and foster economic prosperity. He is now laying the groundwork to establish centers of excellence for vaccine development in the Middle East and North Africa. Dr. Hotez will continue to serve in this role in Sabin awarded the Albert B. Sabin Humanitarian Award in 2015 to Dr. Gary Michelson, a distinguished orthopedic spinal surgeon and inventor, in recognition of his extraordinary philanthropy and commitment toward the control and elimination of NTDs through high-level advocacy and vaccine research and development. As an innovator and a philanthropist, Dr. Michelson s contributions to the field of science and technology have enabled millions of people to live healthier, more productive lives. Carol Ruth Shepherd passed away in May 2016 at age 93. Carol Ruth and her late husband, HR Shepherd, founded Sabin in memory of Dr. Albert B. Sabin in 1993 with Dr. Sabin's widow, Mrs. Heloisa Sabin; Dr. Robert Chanock; and Dr. Philip Russell. The Shepherds forged a vision for Sabin s future, inspiring a commitment to developing vaccines and advocating greater use of existing vaccines and medicine. At age 91, Carol Ruth and many family members proudly attended Sabin s 20th Anniversary. 26

29 FINANCES Sabin has received the highest possible rating on Charity Navigator for nearly a decade. 27

30 Finances Condensed Statement of Activities DECEMBER 31, 2015 AND 2014 REVENUE AND SUPPORT Sabin's Board of Trustees and executive leadership are fully committed to responsible and effective stewardship of donor funding. For the eigth consecutive year, Sabin received Charity Navigator's highest rating possible for consistently executing our mission in a fiscally responsible way. Grants, contributions and other support received Future portion of grants as of year-end Investment income TOTAL EXPENSES Program services General, administrative and fundraising TOTAL 0 20M 40M 60M 80M 0 20M 40M 60M 80M EXCESS OF REVENUES, COMMITMENTS AND SUPPORT OVER EXPENSES 0 20M 40M 60M 80M SPENDING EFFICIENCY RATIO: 89% 11% Program Services General, Administrative and Fundraising 28

31 Finances Condensed Statement of Financial Position DECEMBER 31, 2015 AND 2014 ASSETS Cash, equivalents and other current assets Investments Other assets The financial statements presented have been summarized from Sabin's audited financial statements. Sabin's full audit report, completed by Rogers & Co, LLP, is available at TOTAL ASSETS 0 10M 20M 30M LIABILITIES AND NET ASSETS Accounts payable and accrued expenses Other liabilities TOTAL LIABILITIES ALLOCATION OF PROGRAM EXPENSES: 45% Vaccine Development Unrestricted net assets Temporarily restricted net assets TOTAL NET ASSETS TOTAL LIABILITIES AND NET ASSETS 0 10M 20M 30M 0 10M 20M 30M 0 10M 20M 30M 41% Vaccine Advocacy and Education 14% Global Network 29

32 Thank you to all of our partners. We are grateful for your support, which makes Sabin s important work possible. View all of Sabin's partners at sabin.org/thank-you-2015 Sabin Vaccine Institute 2000 Pennsylvania Avenue, NW Suite 7100 Washington, D.C Visit sabin.org Donate at sabin.org/donate : facebook.com/sabinvaccine Credits PHOTO CREDITS: Olivier Asselin, Baylor College of Medicine, Mignonette Dooley, Anna Grove Photography, Yannis Guibinga, Esther Havens, Join the Lights, Timothy Mwaura, Víctor Norambuena, Naveen Pun DESIGN CREDIT: büro svenja DEVELOPMENT CREDIT: paperplane.co, Echo & Co.