Phototherapy Device Effectiveness in Nigeria: Irradiance Assessment and Potential for Improvement
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1 JOURNAL OF TROPICAL PEDIATRICS, VOL. 59, NO. 4, 2013 Brief Report Phototherapy Device Effectiveness in Nigeria: Irradiance Assessment and Potential for Improvement by Benjamin K. Cline, 1,2 Hendrik J. Vreman, 3 Kelly Faber, 4 Hannah Lou, 1 Krista M. Donaldson, 1,5 Emmanuel Amuabunosi, 6 Gabriel Ofovwe, 6 Vinod K. Bhutani, 3 Bolajoko O. Olusanya, 7 and Tina M. Slusher 8,9 1 D-Rev: Design Revolution, San Francisco, CA 94107, USA 2 Department of Mechanical Engineering, Stanford University Medical Center, Stanford, CA 94305, USA 3 Department of Pediatrics, Stanford University, Stanford, CA 94305, USA 4 Pediatrics, University of Louisville, Louisville, KY 40202, USA 5 Hasso Plattner Institute of Design, Stanford University, Stanford, CA 94305, USA 6 Paediatrics, University of Benin, Benin City, Edo State, Nigeria 7 Department of Community Health and Primary Care, College of Medicine, University of Lagos, Lagos, Lagos State, Nigeria 8 Department of Pediatrics, University of Minnesota, Minneapolis, MN 55415, USA 9 Hennepin County Medical Center, Minneapolis, MN 55415, USA Correspondence: B. O. Olusanya, Department of Community Health and Primary Care, College of Medicine, University of Lagos, Lagos, Lagos State, Nigeria. Tel: þ <bolajoko.olusanya@uclmail.net>. Summary This study investigated the effectiveness of simple-to-implement adjustments of phototherapy devices on irradiance levels in a cross-section of Nigerian hospitals. A total of 76 phototherapy devices were evaluated in 16 hospitals while adjustments were implemented for a subset of 25 devices for which consent was obtained. The mean irradiance level was mw/cm 2 /nm for all devices prior to adjustments. The average irradiance level improved from 9.0 mw/cm 2 /nm to 27.3 mw/cm 2 /nm for the adjusted group (n ¼ 25) compared with mw/cm 2 /nm for the unadjusted group (n ¼ 51). Simple, inexpensive adjustments to phototherapy devices with sub-optimal irradiance levels can significantly improve their effectiveness to acceptable international standards and should be widely promoted in resource-constrained settings. Key words: newborn jaundice, hyperbilirubinemia, phototherapy, irradiance, developing countries. Acknowledgements The authors gratefully acknowledge the doctors and nurses in Nigeria who spoke with us and provided access to their facilities. We would like to thank Prof. David K. Stevenson and his laboratory at the Stanford University School of Medicine, for their continued support of this project. Finally we would like to thank Serena Silvaggio, West Virginia University for her administrative support. Funding This work was supported and funded in part by the National Collegiate Inventors and Innovators Alliance Grant (B.K.C.) and the Christopher Hess Research Fund (H.J.V.). Introduction Neonatal hyperbilirubinemia (NHB) is ubiquitous in newborns and remains a major cause of post-partum hospital (re)admission globally [1, 2]. Although timely use of high performance phototherapy devices has been established in the effective management of NHB [3], the condition still remains a leading cause of morbidity and mortality in resource-constrained settings [4 7]. Exchange blood transfusions (EBT) are frequent and inevitable in these settings due to late or ineffective treatment with phototherapy [8 10] thus placing the survivors at risk of adverse life-long neurological outcomes including kernicterus, deafness and cerebral palsy [11 14]. Whereas over 99.5% of term newborns with severe NHB in the USA are treated solely and successfully with phototherapy [1], widespread use of sub-optimal phototherapy devices have been implicated for ß The Author [2013]. Published by Oxford University Press. All rights reserved. For Permissions, please journals.permissions@oup.com 321 doi: /tropej/fmt027 Advance Access published on 10 May 2013
2 unusually high rates of EBT in countries such as Nigeria [8]. A similar study which may not be unrelated to the effectiveness of treatment, found an uncommon risk of sensorineural hearing loss among newborns who received phototherapy prior to hospital discharge [15]. Irradiance is a key and easy-to-measure parameter for the effectiveness of phototherapy devices in resource-constrained settings [16]. Irradiance levels are not only determined by the quality of the light source but also based on the distance between the device and the patient [17]. We therefore set out to evaluate irradiance levels of phototherapy units in use in a sample of hospitals in Nigeria to identify practical and inexpensive measures to improve performance of sub-optimally operating devices. Materials and Methods Seventy-six functional phototherapy devices in 16 Nigerian hospitals were assessed and irradiance levels measured during March April Facilities included private and government hospitals with large catchment areas of rural and urban populations to ensure representative sampling of nurseries covering all socio-economic groups in Nigeria. Sites were selected using convenience sampling and included nine public, three private and four religiously affiliated hospitals. As an observational study with nested sub-cohort for remedial intervention, no patient data were evaluated or recorded, and IRB approval was not required. Only phototherapy devices currently in use and functional reserves were included in the study. Devices modified by hospital staff after our arrival and prior to evaluation (n ¼ 2) were excluded. Parameters of interest for each device are listed in Table 1. Initial measurements were taken for each device as they were normally used. Irradiance was measured using a GE Healthcare BiliBlanket Light Meter I or II, or Minolta Fluoro-Lite 451 meter, which yield similar irradiance values [Vreman unpublished data], with the meter positioned at the newborn s abdomen height (10 cm above the mattress). Phototherapy devices not in use for patient care were turned on and allowed a minimum of 5 min to fully warm lamps. Half of the facilities (n ¼ 8), gave consent to implement series of adjustments (Table 2) for a total of 25 devices. After implementing adjustments that could demonstratively improve device performance, irradiance and distance of lamp from baby were re-measured. Data using Student s t-test are presented as mean SD. Based on the guidelines from the American Academy of Pediatrics (AAP), irradiance levels of 8 10 mw/cm 2 /nm were considered as minimal or adequate while levels of up to TABLE 1 Parameters recorded for each phototherapy device 1. Spectral irradiance (mw/cm 2 /nm). 2. Distance between emissions surface of phototherapy device and abdominal surface of newborn (cm). 3. Total number of illumination sources. 4. Number of currently functional illumination sources. 5. Color of light emitted from each illumination source (assessed visually). 6. Device manufacturer and model. TABLE 2 Adjustments made to improve phototherapy device performance Decreasing the distance between device and patient. Improving alignment of device relative to the patient, ensuring illumination footprint is centered about the patient. Replacing bulbs: inserting functional bulbs for broken or missing bulbs, replacing non-blue bulbs with blue bulbs. Removing dust from lamps and from the plastic screen between the lamps and patient (for devices with such a screen). Turning all switches on for devices controlled by multiple switches. 30 mw/cm 2 /nm were considered as intensive phototherapy [18]. Results Mean irradiance of all PT devices was mw/ cm 2 /nm. The distribution of device irradiance is presented in Figure 1. Only one device (1.3%) exceeded the AAP standards. Twenty-nine devices (38.2%) were below 5 mw/cm 2 /nm. Commercially manufactured devices (n ¼ 68) had higher, statistically significant (p < 0.01) spectral irradiance ( mw/cm 2 / nm) than home-made devices ( mw/cm 2 /nm). Mean spectral irradiance of the adjusted devices (n ¼ 25) was significantly improved (p < 0.001) from mw/cm 2 /nm to mw/cm 2 /nm after the adjustments (Fig. 2). However, the observed trend toward higher mean irradiance among these 322 Journal of Tropical Pediatrics Vol. 59, No. 4
3 FIG. 1. Distribution of irradiance of all measured phototherapy devices (n ¼ 76), including n ¼ 68 commercially manufactured and n ¼ 8 locally made devices. Irradiance ranged from 0.3 mw/cm 2 /nm to 30 mw/cm 2 /nm. FIG. 2. Irradiances of devices before and after adjustments for the nested sub-group of devices that were adjusted (n ¼ 25). The results are in ascending order of irradiance before adjustments. devices compared to other devices ( vs mw/cm 2 /nm) did not reach statistical significance (p ¼ 0.06). Many devices were found to be at an excessive distance from the baby (Fig. 3). The mean distance was cm (range cm). This included both structurally fixed and adjustable height devices. For adjustable height devices in the nested sub-cohort, adjusting distance improved irradiance. Similarly, replacing widely used white bulbs with Journal of Tropical Pediatrics Vol. 59, No
4 FIG. 3. Distribution of distance of light source to patient for all overhead devices (n ¼ 73). Values ranged from 20 cm to 79 cm. spectrally superior blue illumination sources, available at comparable cost, also improved device effectiveness. Discussion This study demonstrated the efficacy of simple-to-implement adjustments in providing higher therapeutic irradiance levels from 9.0 mw/cm 2 /nm to 27.3 mw/ cm 2 /nm. After adjustments, 10 devices (40%) exceeded the AAP intensive phototherapy standard, compared with 0 device beforehand. This underscores the importance of education regarding delivery of phototherapy, as well as monitoring and maintenance of devices. The findings of sub-optimal irradiance levels in our sample which were partially due to the sub-optimal positioning and inadequate maintenance of devices are consistent with previous surveys in Nigeria [16] and other resource-constrained settings [19]. Phototherapy units typically costing US$3000 or more are prohibitively expensive for many developing countries. Even hospitals that provide phototherapy treatment lack the ability to measure device irradiance as only one hospital in this study had access to an irradiance meter, obtained through a research study. Further hindrances such as unreliable electrical power supply and surges often caused voltage spikes that exceed device design limits. Voltage stabilizers may be cost-prohibitive and may not function as rated to protect against device damage. Additionally, availability of replacement parts such as spectrally optimized special blue (BB) fluorescent tubes is a perennial challenge. Knowledge of technical requirements for effective phototherapy varied widely among medical staff. Many claimed that they had been taught to use 45 cm as the distance between device and newborn. Evidence from this study thus demonstrates the need for improved education on the correct positioning and maintenance of phototherapy devices wherever provided. In conclusion, a uniform maintenance checklist to assure effective phototherapy treatment in resourceconstrained settings is needed and should include elements of proper irradiance monitoring, availability of replacement parts and continuous education for relevant hospital staff. Such practical and inexpensive interventions would be pivotal to curtailing EBT as well as NHB-related morbidity and mortality in settings with access to phototherapy devices. References 1. Burke BL, Robbins JM, Bird TM, et al. Trends in hospitalizations for neonatal jaundice and kernicterus in the United States, Pediatrics 2009;123: The Young Infants Clinical Signs Study Group. Clinical signs that predict severe illness in children under age 2 months: a multicentre study. Lancet 2008;371: Bhutani VK, Johnson LH, Jeffrey Maisels M, et al. Kernicterus: epidemiological strategies for its 324 Journal of Tropical Pediatrics Vol. 59, No. 4
5 prevention through systems-based approaches. J Perinatol 2004;24: English M, Ngama M, Musumba C, et al. Causes and outcome of young infant admissions to a Kenyan district hospital. Arch Dis Child 2003;88: Kapoor RK, Srivastava AK, Misra PK, et al. Perinatal mortality in urban slums in Lucknow. Indian Pediatr 1996;33: Kilic S, Tezcan S, Tascilar E, et al. Morbidity and mortality characteristics of infants hospitalised in the Pediatrics Department of the largest Turkish military hospital in Military Med 2005;70: Ezeaka VC, Ogunbase AO, Awogbemi OT, et al. Why our children die: a review of paediatric mortality in a tertiary centre in Lagos, Nigeria. Nig Q J Hosp Med 2003;13: Owa JA, Ogunlesi TA. Why we are still doing so many exchange blood transfusion for neonatal jaundice in Nigeria. World J Pediatr 2009;5: Salas AA, Mazzi E. Exchange transfusion in infants with extreme hyperbilirubinemia: an experience from a developing country. Acta Paediatr 2008;97: Al-Hiali S, Al-Diwan JK, Al-Janabi M, et al. Exchange transfusion in a neonatal unit in western Iraq. Ann Trop Paediatr 2007;27: Mukhopadhyay K, Chowdhary G, Singh P, et al. Neurodevelopmental outcome of acute bilirubin encephalopathy. J Trop Pediatr 2010;56: Gordon AL, English M, Tumaini Dzombo J, et al. Neurological and developmental outcome of neonatal jaundice and sepsis in rural Kenya. Trop Med Int Health 2005;10: Olusanya BO, Somefun AO. Sensorineural hearing loss in infants with neonatal jaundice in a developing country: a community-based study. Ann Trop Paediatr 2009;29: Duggan MB, Ogala W. Cerebral palsy in Nigeria: a report from Zaria. Ann Trop Paediatr 1982;2: Olusanya BO. Newborns at risk of sensorineural hearing loss in low-income countries. Arch Dis Child 2009; 94: Owa JA, Adebami OJ, Fadero FF, et al. Irradiance readings of phototherapy equipment: Nigeria. Indian J Pediatr 2011;78: Strauss KA, Robinson DL, Vreman HJ, et al. Management of hyperbilirubinemia and prevention of kernicterus in 20 patients with Crigler-Najjar disease. Eur J Pediatr 2006;165: American Academy of Pediatrics Subcommittee on Hyperbilirubinemia. Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics 2004;114: Pejaver RK, Vishwanath J. An audit of phototherapy units. Indian J Pediatr 2000;67: Journal of Tropical Pediatrics Vol. 59, No
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