CURRICULUM VITAE. Assistant Professor of Diagnostic and Interventional Imaging

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1 CURRICULUM VITAE July 22, 2013 NAME: PRESENT TITLE: Sushmita Datta, Ph.D. Assistant Professor of Diagnostic and Interventional Imaging ADDRESS: 3780 Copperfield Drive, Apt. 928 Bryan, TX BUSINESS ADDRESS: Department of Diagnostic and Interventional Imaging The University of Texas-Houston Health Science Center, Medical School, MSE R Fannin Street Houston, Texas BIRTHDATE: July 13, 1973 CITIZENSHIP: UNDERGRADUATE EDUCATION: GRADUATE EDUCATION: India Maharshi Dayanand Saraswati University, Ajmer Rajasthan, India B.Sc. Indian Institute of Technology Kanpur, India 2003 Ph.D., Mathematics Indian Institute of Technology Kanpur, India 1995 M.Sc., Mathematics ACADEMIC APPOINTMENTS: Assistant Professor Diagnostic and Interventional Imaging Medical School University of Texas-Houston Health Science Center 2008-Present Post-doctoral Fellow Department of Diagnostic and Interventional Imaging Medical School University of Texas-Houston Health Science Center PROFESSIONAL ORGANIZATIONS: International Society of Magnetic Resonance in Medicine in Medicine (ISMRM) present 1

2 EDITORIAL Reviewer, Abstracts for IEEE Engineering in Medicine and Biology POSITIONS: Society Conference Reviewer, Abstracts for ISMRM Conference present Reviewer, Radiology present MENTOR: Students (Summer 2009 & 2010), Research Associates (2011, 2012) AWARDS: Radiology Editor s Recognition Award for reviewing with Distinction (2011, 2012) CURRENT GRANT SUPPORT: ACTIVE 1 R01 NS A1 (Narayana) 9/1/2012 5/31/ Calendar NIH/NINDS Annual DC $ 218,750 Lesion Activity and Atrophy in Multiple Sclerosis: Analysis of Multi-center MRI Major Goals: The analysis of longitudinal MRI data on a multi-center cohort GMO / PO# RGC (Lincoln) 9/1/13-8/30/ Calendar UT Southwestern Medical Center Annual DC $322,717 Alternative Treatment Paradigm for Natalizumab trial Major Goals: HMR1726/EFC6260 (Wolinsky) 10/1/07 3/1/ Calendar Study Efc6260: Teriflunomide Teriflunomide in clinically isolated syndrome (early MS). A randomized, double-blind, placebocontrolled, parallel-group design study. Major Goals: To evaluate the efficacy & safety of teriflunomide in subjects with a first clinical episode suggestive of MS. PUBLICATIONS A. ABSTRACTS: 1. Datta, S., Staewen, T.D., Goel, P., Cofield, S.S., Cutter, G.R., Lublin, F.D., Wolinsky, J.S., and Narayana, P.A. Regional Gray Matter Atrophy in Multiple Sclerosis using Tensor Based Morphometry: A Multi-Center Study. Proc. 21st Scientific Meeting of ISMRM at Salt Lake City, USA, April, Datta, S., Narayana, P.A. Automated Identification of Lesion Activity in Multiple Sclerosis BMES Annual Meeting at Atlanta, USA, October Datta, S., Sun, X., Shukla, K., and Narayana, P.A. Improving lesion classification using an empirical knowledge of false classifications in multiple sclerosis. Proc. 20th Scientific Meeting of ISMRM at Melbourne, Australia, May

3 4. Datta, S., Sun, X., Shukla, K., and Narayana, P.A. Improved segmentation with highresolution 3D MR images in MS. Proc. 17th Annual Meeting of the Organization of human Brain Mapping at Quebec City, Canada, June Datta, S., Sun, X., and Narayana, P.A. Cerebellar GM-WM segmentation accuracy in assessing brain atrophy. Proc. 19th Scientific Meeting of ISMRM at Montreal, Quebec, Canada, May, Datta, S., Wolinsky, J.S., and Narayana, P.A. Knowledge-Driven Automated Segmentation of Cortical Lesions on MR Brain Images in MS. Proc. 18th Scientific Meeting of ISMRM at Stockton, Sweden, May Tao, G., Datta, S., He, R., and Narayana, P.A. Atrophy and Shape Changes in Deep Gray Matter in Multiple Sclerosis: A Tensor Based Morphometry. Proc. 17th Scientific Meeting of ISMRM at Hawaii, USA, April Poonawalla, A.H., Datta, S., Juneja, V., Nelson, F., Wolinsky, J.S., Cutter, G., and Narayana, P.A. Improved correlation of composite MRI scores with EDSS in Multiple Sclerosis. Proc. 17th Scientific Meeting of ISMRM at Hawaii, USA, April Poonawalla, A.H., Datta, S., Juneja, V., Nelson, F., Wolinsky, J.S., Cutter, G., and Narayana, P.A. Inverse dependence between patient population and correlation of composite MRI scores with EDSS in Multiple Sclerosis. Proc. 17th Scientific Meeting of ISMRM at Hawaii, USA, April Hasan, K.M., Kamali, A., Iftikhar, A., Datta, S., Nelson, F., Wolinsky, J.S., and Narayana, P.A. Diffusion Tensor Tractogrpahy Quantification of Wallerian Degeneration of the Uncinate Fasciculus in Multiple Sclerosis. Proc. 17th Scientific Meeting of ISMRM at Hawaii, USA, April He, R., Datta, S., Tao, G., and Narayana, P.A. Information Measures-Based Intensity Standardization of MRI. IEEE EMBS International Conference, Vancouver, Canada, August Tao, G., Datta, S., He, R., and Narayana, P.A. Mutual Information Driven Inverse Consistent Nonlinear Registration. IEEE EMBS International Conference, Vancouver, Canada, August Datta, S., Sajja, B.R., He, R., Dieber, J.M., Wolinsky, J.S., and Narayana P.A. Segmentation of MR Brain Images with Intensity Correction and Partial Volume Averaging. Proc. 16th Scientific Meeting of ISMRM at Toronto, Canada, May Tao, G., He, R., Datta, S., and Narayana, P.A. Inverse Consistent Geometric Flow based Nonlinear Registration Driven by Mutual Information. Proc. 16th Scientific Meeting of ISMRM at Toronto, Canada, May Poonawalla, A.H., Datta, S., Nelson, F., Wolinsky, J.S., and Narayana, P.A. High Resolution 3

4 3D MRI of Cortical Lesions in Multiple Sclerosis. Proc. 15th Scientific Meeting of ISMRM at Berlin, Germany, May Sajja, B.R., Datta, S., He, R., and Narayana, P.A. Fast Segmentation of MR Brain at 3T using Phase Sensitive Inversion Recovery Images. Proc. 15th Scientific Meeting of ISMRM at Berlin, Germany, May Datta, S., Sajja, B.R., He, R., Wolinsky, J.S., and Narayana, P.A. Segmentation of Gray- And White Matter on MR Brain Images in Multiple Sclerosis. Proc. 14th Scientific Meeting of ISMRM at Seattle, USA, May He, R., Datta, S., Sajja, B.R., and Narayana, P.A. Histogram-Based Acceleration of EM Algorithm for Segmentation of Multi-Spectral MRI with Contextual Constraints. Proc. 14th Scientific Meeting of ISMRM at Seattle, USA, May Mogatadakala, K.V., Datta, S., Poonawalla, A.H., Hasan, K.M., Wolinsky, J.S., and Narayana, P.A. Identification of Abnormal White Matter in Multiple Sclerosis. Proc. 14th Scientific Meeting of ISMRM at Seattle, USA, May Bhat, H.V., Sajja, B.R., Datta, S., and Narayana, P.A. Fast Analysis of 1H Magnetic Resonance Spectroscopic Imaging Data: An Artificial Neural Network Based Approach. Proc. 14th Scientific Meeting of ISMRM at Seattle, USA, May Datta, S., Sajja, B.R., He, R., and Narayana, P.A. Automatic Segmentation of Black Holes in Multiple Sclerosis on MR Images. Proc.13th Scientific Meeting of ISMRM at Miami, USA, May Sajja, B.R., Datta, S., He, R., and Narayana, P.A. Minimization of False MS Lesion Classifications on MR Images: Quantitative Validation. Proc. 13th Scientific Meeting of ISMRM at Miami, USA, May Sajja, B.R., Datta, S., He, R., and Narayana, P.A. A Unified Approach for Lesion Segmentation on MRI of Multiple Sclerosis. IEEE EMBS International Conference, San Francisco, USA, September He, R., Datta, S., Sajja, B.R., Mehta, M., and Narayana, P.A. Adaptive FCM with contextual constrains for segmentation of multi-spectral MRI. IEEE EMBS International Conference, San Francisco, USA, September Rathore, R.K.S., Datta, S., Gupta, R.K., Rao, S.B., and Verma, R. An MLE Based Segmentation Method for Quantitation in MR Images. Proc. 9th Scientific Meeting of ISMRM at Glasgow, April Datta, S., Rao, S.B., Rathore, R.K.S., Gupta, R.K., and Verma, R. A Segmentation Method Based on Maximum Likelihood Estimation for Quantitation in MR Images. Symposium on Spatially Resolved Magnetic Resonance & 7th NMRS Symposium, Chennai, February 7-10,

5 27. Rao, S.B., Datta, S., Rathore, R.K.S., Gupta, R.K., and Verma, R. A Numerical Study of Errors in Tissue Parameter Estimation. Symposium on Spatially Resolved Magnetic Resonance & 7th NMRS Symposium, Chennai, February 7-10, Rathore, R.K.S., Gupta, R.K., Kaliprasad, V.S.N., Rao, S.B., and Datta, S. Iterative Sharpening of the Resolution in Magnetic Resonance Imaging. Proc. Scientific Meeting of ISMRM at Colorado, USA, April Datta, S., Gupta, R.K., Rao, S.B., Kaliprasad, V.S.N., and Rathore, R.K.S. Segmentation of Lesions in MRI using Cubic Splines. National Symposium on Magnetic Resonance and Biomolecular Structure and Function, TIFR India, January 17-20, Rao, S.B., Gupta, R.K., Kaliprasad, V.S.N., Datta, S., and Rathore, R.K.S. A Robust Method for Tissue Parameters Estimation in MR Imaging. National Symposium on Magnetic Resonance and Biomolecular Structure and Function, TIFR India, January 17-20, B. REFEREED ORIGINAL ARTICLES IN JOURNALS: 1. Wolinsky, J.S., Narayana, P.A., Nelson, F., Datta, S., O'Connor, P., Confavreux, C., Comi, G., Kappos, L., Olsson, T.P., Truffinet, P., Wang, L., Miller, A., Freedman, M.S.; for the Teriflunomide Multiple Sclerosis Oral (TEMSO) Trial Group. Magnetic resonance imaging outcomes from a phase III trial of teriflunomide. Multiple Sclerosis, 2013 (in press). 2. Narayana, P.A., Zhou, Y., Hasan, K.M., Datta, S., Sun, X., and Wolinsky, J.S. Hypoperfusion and T1-hypointense lesions in white matter in multiple sclerosis. Multiple Sclerosis Journal, 2013 (accepted). 3. Datta, S., and Narayana, P.A. A comprehensive approach to the segmentation of multichannel three-dimensional MR brain images in multiple sclerosis. Neuroimage: Clinical 2: , Narayana, P.A., Govindarajan, K.A., Goel, P., Datta, S., Lincoln, J.A., Cofield, S.S., Cutter, G.R., Lublin, F.D., and Wolinsky, J.S. Regional cortical thickness in relapsing remitting multiple sclerosis: A multi-center study. Neuroimage: Clinical 2: , Hasan, K.M., Walimuni, I.S., Abid, H., Datta, S., Wolinsky, J.S., and Narayana, P.A. Human brain atlas-based multimodal MRI analysis of volumetry, diffusimetry, relaxometry and lesion distribution in multiple sclerosis patients and healthy adult controls: Implications for understanding the pathogenesis of multiple sclerosis and consolidation of quantitative MRI results in MS. Journal of the Neurological Sciences 314:99-109, Nelson, F., Datta, S., Garcia, N., Rozario, N.L., Perez, F., Cutter, G., Narayana, P.A., and Wolinsky, J.S. Intracortical lesions by 3T magnetic resonance imaging and correlation with cognitive impairment in multiple sclerosis. Multiple Sclerosis 17: , Datta, S. and Narayana, P.A. Automated brain extraction from T2-weighted magnetic resonance images. Journal of Magnetic Resonance Imaging 33:: , Yu, X., Zhang, Y., Lasky, R.E., Datta, S., Parikh, N.A., and Narayana, P.A. Comprehensive Brain MRI Segmentation in High Risk Preterm Newborns. PLoS One 5:e13874,

6 9. Poonawalla, A.H., Datta, S., Juneja, V., Nelson, F., Wolinsky, J.S., Cutter, G., and Narayana, P.A. Composite MRI Scores Improve Correlation with EDSS in Multiple Sclerosis. Multiple Sclerosis 16: , Narayana, P.A., Datta, S., Tao, G., Steinberg, J.L., and Moeller, F.G. Effect of Cocaine on Structural Changes in Brain: MRI Volumetry using Tensor-Based Morphometry. Drug and Alcohol Dependence 111: , Datta, S., Tao, G., He, R., Wolinsky, J.S., and Narayana, P.A. Improved Cerebellar Tissue Classification on Magnetic Resonance Images of Brain. Journal of Magnetic Resonance Imaging 29: , Tao, G., He, R., Datta, S., and Narayana, P.A. Symmetric inverse consistent nonlinear registration driven by mutual information. Computer Methods and Programs in Biomedicine 95: , Tao, G., Datta, S., He, R., Nelson, F., Wolinsky, J.S., and Narayana, P.A. Deep Gray Matter Atrophy in Multiple Sclerosis: A Tensor Based Morphometry. Journal of the Neurological Sciences 282:39-46, He, R., Sajja, B.R., Datta, S., and Narayana, P.A. Volume and Shape in Feature Space on Adaptive FCM in MRI Segmentation. Annals of Biomedical Engg. 36: , He, R., Datta, S., Sajja, B.R., and Narayana, P.A. Generalized Fuzzy Clustering for Segmentation of Multi-Spectral Magnetic Resonance Images. Computerized Medical Imaging and Graphics 32: , Datta, S., Sajja, B.R., He, R., Gupta, R.K., Wolinsky, J.S., and Narayana, P.A. Segmentation of gadolinium-enhanced lesions on MRI in multiple sclerosis. Journal of Magnetic Resonance Imaging 25: , Datta, S., Sajja, B.R., He, R., Wolinsky, J.S., Gupta, R.K., and Narayana, P.A. Narayana, Segmentation and quantification of black holes in Multiple Sclerosis. Neuroimage 29: , Sajja, B.R., Datta, S., He, R., Mehta, M., Gupta, R.K., Wolinsky, J.S., and Narayana, P.A. Unified Approach for Multiple Sclerosis Lesion Segmentation on Brain MRI. Annals of Biomedical Engg. 34: , Gupta, R.K., Husain, N., Kathuria, M.K., Datta, S., Rathore, R.K.S., and Husain, M. Magnetization Transfer MR Imaging Correlation with Histopathology in Intracranial Tuberculomas. Clinical Radiology 56: ,