Predictive Biomarkers in GBM
|
|
- Gabriel Walsh
- 5 years ago
- Views:
Transcription
1 Predictive Biomarkers in GBM C. David James, Ph.D. Professor & Associate Director, Brain Tumor Research Center Dept. Neurological Surgery and Helen Diller Comprehensive Cancer Center, University of California San Francisco
2 During the past 10 years, glioblastoma diagnosis has been refined by including molecular profiling that has promoted tumor subclassification Initial tumor classification, however, continues to be based on morphologic characteristics Presumed cell of origin: Astryocytes -> astrocytoma -> glioblastoma? Oliododendrocytes -> oligodendroglioma Ependymal Cells -> ependymoma oligodendroglioma astrocytoma
3 Numerical malignancy grading based on the presence or absence of specific morphologic features grade II vs. grade III: absence vs. presence of mitotic figures grade III vs. grade IV: absence vs. presence of necrosis and/or endothelial cell proliferation
4 Prognosis based on morphology is very imprecise Early attempt at glioma classification based on tumor genetic characteristics Am J Pathology 159: , 2001 Cancer Cell: 1: , 2002
5 First, widely referred to molecular classification scheme Cancer Cell 9: , 2006
6 The current, most frequently cited classifcation scheme for GBM was developed in association with The Cancer Genome Atlas project Cancer Cell 17:98-110, 2010.
7 The transcriptome defined GBM subtypes are associated with specific gene alterations Cancer Cell 17:98-110, 2010.
8 The TCGA analysis of GBM highlighted three core pathways that are deregulated during tumor development
9 Johns Hopkins Duke initiative sequenced 20,661 protein coding genes Identified IDH1 mutation in secondary GBM. This mutation was subsequently identified in large percentages of grade II and grade III gliomas. N Engl J Med. 360:765-73, 2009
10 The most recent additions to the catalogue of common GBM alterations involve genes that encode chromatin packaging and modifying proteins. Nature 482: , 2012
11 Recent presentation and attempt of a comprehensive, integrated model to account for GBM subgroups Cancer Cell 22: , 2012 Highlights an emerging avenue of investigation in brain tumor research: gene alterations causing GBM may have temporal (age) and neuroanatomical dependencies
12 All information presented thus far has involved tumor classifications based on somatic gene alterations What about inherited predisposition? Recent GWAS studies suggest inherited risk factors. Cancer Genetics 205: , 2012 Original source publications: Nat Genet. 44:1122-5, 2012 Nat Genet. 41:905-8, 2009
13 Attempts at associating molecular classification with morphologic features Is this necessary? A major point of the molecular classification is to move away from morphologic, descriptive classification. J Am Med Inform Assoc 19:317-23, 2012
14 Where does this leave us regarding treatment options, as informed by tumor molecular profiling? Each pathway provides multiple opportunities for treatment intervention
15 IDH mutations Brain Tumor Pathol 29:
16 Chromatin packaging/modifying mutations Cancer Cell 21: , 2012
17 13 years ago my lab began establishing GBM xenografts that are serially-passaged s.c. in athymic mice, rather than propagated in tissue culture X
18 GBM Panel of Genetically-Characterized Xenografts
19 This xenograft series found its way into the TCGA pipeline With their expression profile and genomic analysis revealing representation of 3 of the 4 GBM subtypes. Cancer Cell 17:98-110, 2010.
20 Many of the xenografts produce infiltrative intracranial tumors that are not typically formed when using established cell lines GBM 6 U87 c b a a b c
21 Predictive biomarkers for GBM response to therapy Complicating issue: standard of care Radiation 2 Gy M, W, F x 2 = 12 Gy total
22 Temozolomide ~ 40% GBM do not express MGMT MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med 352: , 2005.
23 Xenograft TMZ response analyses 66 mg/kg
24 EGFR was the first therapeutic target investigated for small molecule inhibition (erlotinib), using the xenograft panel. Mol Cancer Ther 6: , 2007
25 EGFR amplified xenograft showing erlotinib sensitivity
26 Phase I/II trial of erlotinib and temozolomide with radiation therapy in the treatment of newly diagnosed glioblastoma multiforme: North Central Cancer Treatment Group Study N0177. J Clin Oncol 26:5603-9, Because the favorable survival response in the current trial could have been a result of the TMZ, N0177 was compared with EORTC 26981/22981-NCIC, a trial of similar patients treated with RT and TMZ alone. Comparing the study results, there were no significant differences in OS between the two trials, which suggests there is no additional benefit for erlotinib when combined with RT and TMZ.
27 Therapeutic targeting points of oncogene addiction is a concept that is reasonably well accepted as a rational strategy for treating cancer. Most pre-clinical & clinical efforts to date have focused on targeting single points of addiction. Is it rational to simultaneously target multiple points of addiction?
28 BRAFV600E-p16 null mouse allograft results BRAFV600E-p16 null human xenograft results Huillard et al., PNAS 109:8710-5, 2012
29 Major obstacles to improved treatment outcomes Selection for and/or creation of therapy resistant subpopulations
30 Tumor adaptation to erlotinib in press, Cancer Discovery
31 2. The blood-brain-barrier: limits therapeutic access to intracranial tumor ~ 85 direct intratumoral ~ 90 ~ 17,000 < 1 Liposomal Packing Liposomal Packing + Direct Intratumoral Delivery
32 Direct intratumoral administration promotes increased extent of therapeutic anti-tumor activity, resulting in a reduced rate of tumor growth and improved survival * * Note high cure rate
33 Deserving of additional investigation? Sequencing of cytotstatic and cytotoxic therapies
34 Improved treatment outcomes for GBM may require innovative therapeutic fomulations as well as innovative approaches for administering therapy, in order to circumvent the limiting influence of the blood brain barrier. Summary and Conclusions As for nearly all types of cancer, our understanding and treatment of brain tumors, especially glioblastoma (GBM), is in an interesting time of transition that is being driven by the rapid increase in information about tumor-associated gene alterations. Appreciation of the need for multi-modality treatment of GBM is now pervasive within the field of neuro-oncology, and it can be anticipated that there will be a substanial increase in testing novel, molecularly informed combination therapies for treating this cancer. Standard of care therapy for treating GBM poses a complication for evaluating new therapies and therapeutic combinations.
35 Many colleagues/collaborators have contributed to these studies Mayo Clinic Jann Sarkaria Ajay Pandita Caterina Giannini UCSF Tomoko Ozawa Mike Prados Scott VandenBerg Rintaro Hashizume Martin McMahon Laura Serwer David Rowitch Claudia Petritsch Other Todd Waldman, GLCCC David Solomon, GLCCC Paul Mischel, UCLA David Nathanson, UCLA
Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma
Supplementary information for: Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma Rintaro Hashizume 1, Noemi Andor 2, Yuichiro Ihara 2, Robin Lerner 2, Haiyun
More informationContemporary Management of Glioblastoma
Contemporary Management of Glioblastoma Incidence Rates of Primary Brain Tumors Central Brain Tumor Registry of the United States, 1992-1997 100 Number of Cases per 100,000 Population 10 1 0.1 x I x I
More informationCorporate Medical Policy
Corporate Medical Policy Analysis of MGMT Promoter Methylation in Malignant Gliomas File Name: Origination: Last CAP Review: Next CAP Review: Last Review: analysis_of_mgmt_promoter_methylation_in_malignant_gliomas
More informationGlioblastoma: Adjuvant Treatment Abdulrazag Ajlan, MD, MSc, FRCSC, UCNS(D)
Glioblastoma: Adjuvant Treatment Abdulrazag Ajlan, MD, MSc, FRCSC, UCNS(D) *Neurosurgery Consultant, King Saud University, Riyadh, KSA *Adjunct Teaching Faculty, Neurosurgery, Stanford School Of Medicine,
More informationAdvances in Brain Tumor Research: Leveraging BIG data for BIG discoveries
Advances in Brain Tumor Research: Leveraging BIG data for BIG discoveries Jill Barnholtz-Sloan, PhD Associate Professor & Associate Director for Bioinformatics and Translational Informatics jsb42@case.edu
More informationWhat yield in the last decade about Molecular Diagnostics in Neuro
What yield in the last decade about Molecular Diagnostics in Neuro Oncology? Raphael Salles S.Medeiros Neuropathologist at HC FMUSP Clinical Research Project Manager at Oncology department at Hospital
More informationNeuro-Oncology Program
Neuro-Oncology Program The goals of the Neuro-oncology Committee are: 1) to improve duration and quality of life of brain tumor patients; 2) to assess disease and treatment-related effects on neurocognitive
More informationSystemic Treatment. Third International Neuro-Oncology Course. 23 May 2014
Low-Grade Astrocytoma of the CNS: Systemic Treatment Third International Neuro-Oncology Course São Paulo, Brazil 23 May 2014 John de Groot, MD Associate Professor, Neuro-Oncology UT MD Anderson Cancer
More informationMALIGNANT GLIOMAS: TREATMENT AND CHALLENGES
MALIGNANT GLIOMAS: TREATMENT AND CHALLENGES DISCLOSURE No conflicts of interest to disclose Patricia Bruns APRN, CNS Givens Brain Tumor Center Abbott Northwestern Hospital October 12, 2018 OBJECTIVES THEN
More informationPROCARBAZINE, lomustine, and vincristine (PCV) is
RAPID PUBLICATION Procarbazine, Lomustine, and Vincristine () Chemotherapy for Anaplastic Astrocytoma: A Retrospective Review of Radiation Therapy Oncology Group Protocols Comparing Survival With Carmustine
More information21/03/2017. Disclosure. Practice Changing Articles in Neuro Oncology for 2016/17. Gliomas. Objectives. Gliomas. No conflicts to declare
Practice Changing Articles in Neuro Oncology for 2016/17 Disclosure No conflicts to declare Frances Cusano, BScPharm, ACPR April 21, 2017 Objectives Gliomas To describe the patient selection, methodology
More informationUniversity of Zurich. Temozolomide and MGMT forever? Zurich Open Repository and Archive. Weller, M. Year: 2010
University of Zurich Zurich Open Repository and Archive Winterthurerstr. 190 CH-8057 Zurich Year: 2010 Temozolomide and MGMT forever? Weller, M Weller, M (2010). Temozolomide and MGMT forever? Neuro-Oncology,
More informationRINDOPEPIMUT (CDX-110) IN GLIOBLASTOMA
RINDOPEPIMUT (CDX-110) IN GLIOBLASTOMA MULTIFORM GEINO 2014 Dra Estela Pineda Madrid Hospital Clínic Barcelona EGFRvIII in glioblastoma multiform The most common mutation of EGFR in GBM Expressed in 30%
More informationLow grade glioma: a journey towards a cure
Editorial Page 1 of 5 Low grade glioma: a journey towards a cure Ali K. Choucair SIU School of Medicine, Springfield, IL, USA Correspondence to: Ali K. Choucair, MD. Professor of Neurology, Director of
More informationImmunotherapy for Malignant Brain Cancer: Overcoming Immune Suppression to Improve the Clinical Experience
Immunotherapy for Malignant Brain Cancer: Overcoming Immune Suppression to Improve the Clinical Experience Derek Wainwright, PhD Assistant Professor Departments of Neurological Surgery, Microbiology-Immunology
More informationOff-Label Treatments. Clinical Trials for Recurrent GBM UCSF Radiation Oncology Course: Management of Recurrent Disease. Outline
Off-Label Treatments Clinical Trials for Recurrent GBM UCSF Radiation Oncology Course: Management of Recurrent Disease Jennifer Clarke, MD, MPH Assistant Professor Division of Neuro-Oncology Depts of Neurological
More informationThe New WHO Classification and the Role of Integrated Molecular Profiling in the Diagnosis of Malignant Gliomas
The New WHO Classification and the Role of Integrated Molecular Profiling in the Diagnosis of Malignant Gliomas Stefan Prokop, MD Neuropathology Fellow Hospital of the University of Pennsylvania Background
More informationConcomitant (without adjuvant) temozolomide and radiation to treat glioblastoma: A retrospective study
Concomitant (without adjuvant) temozolomide and radiation to treat glioblastoma: A retrospective study T Sridhar 1, A Gore 1, I Boiangiu 1, D Machin 2, R P Symonds 3 1. Department of Oncology, Leicester
More informationEpidemiology of Adult Glioma
Epidemiology of Adult Glioma Joseph Wiemels, PhD San Francisco, CA August 2, 2017 Proportion of Primary Brain Tumors by Histologic Type Other 29% Glioma 44% Meningioma 27% Total Number Cases for 2004 =
More informationPRINCESS MARGARET CANCER CENTRE CLINICAL PRACTICE GUIDELINES
PRINCESS MARGARET CANCER CENTRE CLINICAL PRACTICE GUIDELINES CENTRAL NERVOUS SYSTEM ANAPLASTIC GLIOMAS CNS Site Group Anaplastic Gliomas Author: Dr. Norm Laperriere Date: February 20, 2018 1. INTRODUCTION
More informationPrecision medicine for gliomas
Precision medicine for YAZMIN ODIA, MD MS LEAD PHYSICIAN OF MEDICAL NEURO-ONCOLOGY DISCLOSURES Novocure: Advisory Board for Optune in No other financial conflicts of interest Glioma OVERVIEW INFILTRATIVE,
More informationPrecision medicine: How to exploit the growing knowledge on the evolving genomes of cells to improve cancer prevention and therapy.
Precision medicine: How to exploit the growing knowledge on the evolving genomes of cells to improve cancer prevention and therapy Joe Costello, PhD Department of Neurological Surgery A more accurate and
More informationDouglas Jolly Executive VP R&D Tocagen Inc.
REPLICATING RETROVIRUSES FOR MANIPULATION OF THE TUMOR IMMUNE ECOSYSTEM: PRECLINICAL AND CLINICAL OUTCOMES. Douglas Jolly Executive VP R&D Tocagen Inc. PEGS 2018 IT Track Boston May 1 2018 Outline Phase
More informationPRINCESS MARGARET CANCER CENTRE CLINICAL PRACTICE GUIDELINES
PRINCESS MARGARET CANCER CENTRE CLINICAL PRACTICE GUIDELINES CENTRAL NERVOUS SYSTEM LOW GRADE GLIOMAS CNS Site Group Low Grade Gliomas Author: Dr. Norm Laperriere 1. INTRODUCTION 3 2. PREVENTION 3 3. SCREENING
More informationScottish Medicines Consortium
Scottish Medicines Consortium temozolomide 5, 20, 100 and 250mg capsules (Temodal ) Schering Plough UK Ltd No. (244/06) New indication: for the treatment of newly diagnosed glioblastoma multiforme concomitantly
More informationCilengitide (Impetreve) for glioblastoma multiforme. February 2012
Cilengitide (Impetreve) for glioblastoma multiforme February 2012 This technology summary is based on information available at the time of research and a limited literature search. It is not intended to
More informationChemotherapy in malignant brain tumors
Chemotherapy in malignant brain tumors Frank Zimmermann Institut für Radioonkologie Universitätsspital Basel Petersgraben 4 CH 4031 Basel zimmermannf@uhbs.ch Tumor types Neuro-epithelial tumors - Glioblastoma
More informationIDH1 R132H/ATRX Immunohistochemical validation
IDH1 R132H/ATRX Immunohistochemical validation CIQC/DSM 2016 12 June 2016 0835-0905 Stephen Yip, M.D., Ph.D., FRCPC University of British Columbia Disclosure Statement I have nothing to disclose I will
More informationCNS SESSION 3/8/ th Multidisciplinary Management of Cancers: A Case based Approach
CNS SESSION Chair: Ruben Fragoso, MD/PhD UC Davis Fellow: Michael Cardenas, MD UC Davis Panel: Gordon Li, MD Stanford Seema Nagpal, MD Stanford Jennie Taylor, MD UCSF HPI: 46 yo right handed woman who
More informationIs there a role for EGFR Tyrosine Kinase Inhibitors in recurrent glioblastoma?
Is there a role for EGFR Tyrosine Kinase Inhibitors in recurrent glioblastoma? Juan M Sepúlveda Sánchez Neurooncology Unit Hospital Universitario 12 de Octubre. Madrid Topics 1.-EGFR pathway as a potential
More informationCurrent and Future Treatment Options for Glioblastoma
Current and Future Treatment Options for Glioblastoma Santosh Kesari, MD, PhD, FANA, FAAN Chair, Department of Translational Neurosciences and Neurotherapeutics John Wayne Cancer Institute & Pacific Neuroscience
More informationInnovative Multimodal Imaging Techniques in Brain Tumor Clinical Trials
Innovative Multimodal Imaging Techniques in Brain Tumor Clinical Trials Benjamin M. Ellingson, Ph.D. Assistant Professor of Radiology, Biomedical Physics, and Bioengineering Brain Tumor Imaging Laboratory
More informationGlioblastoma. In this fact sheet: What is a glioblastoma?
Glioblastoma Glioblastomas are the most common primary brain tumours in adults. (Primary means the tumour starts in the brain, rather than starting elsewhere in the body then spreading to the brain). It
More informationGlioblastoma and CNS tumors
Glioblastoma and CNS tumors PRECEPTORSHIP PROGRAMME IMMUNO-ONCOLOGY Amsterdam, 27 May 2017 Patrick Roth Department of Neurology and Brain Tumor Center University Hospital Zurich Challenges in immunooncology
More informationClinical Trials for Adult Brain Tumors - the Imaging Perspective
Clinical Trials for Adult Brain Tumors - the Imaging Perspective Whitney B. Pope, M.D., Ph.D. Department of Radiology David Geffen School of Medicine at UCLA August 22, 2015 1 Disclosure of Financial Relationships
More informationAntibody-Drug Conjugates in Glioblastoma Multiforme: Finding Ways Forward
Transcript Details This is a transcript of a continuing medical education (CME) activity accessible on the ReachMD network. Additional media formats for the activity and full activity details (including
More informationGliomas in the 2016 WHO Classification of CNS Tumors
Gliomas in the 2016 WHO Classification of CNS Tumors Hindi N Al-Hindi, MD, FCAP Consultant Neuropathologist and Head Section of Anatomic Pathology Department of Pathology and Laboratory Medicine King Faisal
More informationNational Horizon Scanning Centre. Bevacizumab (Avastin) for glioblastoma multiforme - relapsed. August 2008
Bevacizumab (Avastin) for glioblastoma multiforme - relapsed August 2008 This technology summary is based on information available at the time of research and a limited literature search. It is not intended
More informationNew Approaches in Brain Tumor Treatment. Virginia Stark-Vance, M.D.
New Approaches in Brain Tumor Treatment Virginia Stark-Vance, M.D. The Primary Brain Tumors es for PicturesMCD for 004.JPG 00 Meningioma 30% Glioblastoma 20% Astrocytoma 10% Nerve sheath 8% Pituitary 6%
More informationCollection of Recorded Radiotherapy Seminars
IAEA Human Health Campus Collection of Recorded Radiotherapy Seminars http://humanhealth.iaea.org The Role of Radiosurgery in the Treatment of Gliomas Luis Souhami, MD Professor Department of Radiation
More informationNovel Concepts to Tackle the Most Aggressive Form of Brain Cancer
Key Opinion Leader Event: Novel Concepts to Tackle the Most Aggressive Form of Brain Cancer Frank A. Giordano, MD Vice Chair & Associate Professor, Dept. of Radiation Oncology, University Medical Center
More informationExamining large groups of cancer patients to identify ways of predicting which therapies cancers might respond to.
Stratified Medicine Examining large groups of cancer patients to identify ways of predicting which therapies cancers might respond to. Looking in detail at cancer cells and their genetic make up. Permit
More informationDOWNLOAD OR READ : THE GLIOMA BOOK PDF EBOOK EPUB MOBI
DOWNLOAD OR READ : THE GLIOMA BOOK PDF EBOOK EPUB MOBI Page 1 Page 2 the glioma book the glioma book pdf the glioma book A glioma is a type of tumor that starts in the glial cells of the brain or the spine.
More informationHypofractionated radiation therapy for glioblastoma
Hypofractionated radiation therapy for glioblastoma Luis Souhami, MD, FASTRO Professor McGill University Department of Oncology, Division of Radiation Oncology Montreal Canada McGill University Health
More informationRadioterapia no Tratamento dos Gliomas de Baixo Grau
Radioterapia no Tratamento dos Gliomas de Baixo Grau Dr. Luis Souhami University Montreal - Canada Low Grade Gliomas Relatively rare Heterogeneous, slow growing tumors WHO Classification Grade I Pilocytic
More informationPioneering vaccines that transform lives.
Pioneering vaccines that transform lives. Immunomic Therapeutics, Inc. LAMP-Vax for Glioblastoma: CMV-LAMP-Vax Executive Summary Executive Summary pp65-lamp-vax First Line Therapy for Glioblastoma Multiforme
More informationMolecular targeted therapeutics for the treatment of cancer patients. August 1, 2016
Molecular targeted therapeutics for the treatment of cancer patients August 1, 2016 Company overview Experienced team with value creating track record in the field of targeted oncology Validated targets
More informationTumors of the Nervous System
Tumors of the Nervous System Peter Canoll MD. PhD. What I want to cover What are the most common types of brain tumors? Who gets them? How do they present? What do they look like? How do they behave? 1
More informationCase Presentation: USCAP Jason T. Huse, MD, PhD Assistant Member Department of Pathology Memorial Sloan Kettering Cancer Center
Case Presentation: USCAP 2016 Jason T. Huse, MD, PhD Assistant Member Department of Pathology Memorial Sloan Kettering Cancer Center Case History 53 year old female with a long standing history of migraines
More informationTreatment with Tumor-Treating Fields therapy and pulse dose bevacizumab in patients with bevacizumab-refractory recurrent glioblastoma: A case series.
School of Medicine Digital Commons@Becker Open Access Publications 2016 Treatment with Tumor-Treating Fields therapy and pulse dose bevacizumab in patients with bevacizumab-refractory recurrent glioblastoma:
More informationBevacizumab in combination with temozolomide and regional radiation therapy for up-front treatment of patients with newly-diagnosed glioblastoma
Bevacizumab in combination with temozolomide and regional radiation therapy for up-front treatment of patients with newly-diagnosed glioblastoma Design and analysis of single-arm Phase II clinical trial
More informationVAL-083: Validated DNA-targeting Agent for Underserved Cancer Patients. September 2018
VAL-083: Validated DNA-targeting Agent for Underserved Cancer Patients September 2018 Forward-Looking Statements Any statements contained in this presentation that do not describe historical facts may
More information2011 Oncology Highlights News from ASCO 2011:
2011 Oncology Highlights News from ASCO 2011: Malignant Glioma David A. Reardon, M.D. Clinical Director Center for Neuro-Oncology Dana-Farber Cancer Institute 450 Brookline Avenue SW-430 Boston, MA 02215
More informationCarmustine implants and Temozolomide for the treatment of newly diagnosed high grade glioma
National Institute for Health and Clinical Excellence Health Technology Appraisal Carmustine implants and Temozolomide for the treatment of newly diagnosed high grade glioma Personal statement Conventional
More informationMorphological features and genetic alterations
Morphological features and genetic alterations Tutor : Audrey Rousseau Caget Lise: Université d Angers Iorio Vittoria: Seconda Università degli studi di Napoli Manaila Roxana: Iuliu Hatieganu University
More informationMOLECULAR DIAGNOSTICS OF GLIOMAS
MOLECULAR DIAGNOSTICS OF GLIOMAS Arie Perry, M.D. Director, Neuropathology Division DIFFUSE GLIOMAS Cell types Astrocytomas (A) Oligodendrogliomas (O) Mixed oligoastrocytoma (MOA) Three WHO grades: II,
More informationMathematical Modeling of PDGF-Driven Glioblastoma Reveals Optimized Radiation Dosing Schedules
Mathematical Modeling of PDGF-Driven Glioblastoma Reveals Optimized Radiation Dosing Schedules Kevin Leder, Ken Pittner, Quincey LaPlant, Dolores Hambardzumyan, Brian D. Ross, Timothy A. Chan, Eric C.
More informationModeling origin and natural evolution of low-grade gliomas
Modeling origin and natural evolution of low-grade gliomas Mathilde Badoual Paris Diderot University, IMNC lab 2nd HTE workshop: Mathematical & Computer Modeling to study tumors heterogeneity in its ecosystem,
More informationMelanoma Research Alliance-Pfizer Academic-Industry Partnership Awards
Melanoma Research Alliance-Pfizer Academic-Industry Partnership Awards Wendy K.D. Selig, President & CEO, MRA Julia Perkins, M.D. Medical Director, Oncology, Pfizer Melanoma Research Alliance Mission:
More informationColorectal Cancer in 2017: From Biology to the Clinics. Rodrigo Dienstmann
Colorectal Cancer in 2017: From Biology to the Clinics Rodrigo Dienstmann MOLECULAR CLASSIFICATION Tumor cell Immune cell Tumor microenvironment Stromal cell MOLECULAR CLASSIFICATION Biomarker Tumor cell
More informationHow genetic & biochemical alterations in brain tumors contribute to epileptogenesis
How genetic & biochemical alterations in brain tumors contribute to epileptogenesis December 2 nd, 2012 Joon H. Uhm, MD FRCPC Departments of Neurology & Oncology Mayo Clinic, Rochester, MN American Epilepsy
More informationUPDATES ON CHEMOTHERAPY FOR LOW GRADE GLIOMAS
UPDATES ON CHEMOTHERAPY FOR LOW GRADE GLIOMAS Antonio M. Omuro Department of Neurology Memorial Sloan-Kettering Cancer Center II International Neuro-Oncology Congress Sao Paulo, 08/17/12 CHALLENGES IN
More informationPrecision oncology through responses and resistance to anti-cancer therapies
Precision oncology through responses and resistance to anti-cancer therapies Barry S. Taylor, Ph.D. Departments of Epidemiology/Biostatistics Medicine/Hematology-Oncology Helen Diller Family Comprehensive
More informationISPOR 4 th Asia Pacific Conference IP2 Gilberto de Lima Lopes
Health Economic Considerations for Personalized Medicine in Asia: Using Genomic Profiling to Guide Treatment Decisions in Early Breast Cancer Gilberto de Lima Lopes, Jr., M.D., M.B.A Assistant Director
More informationGlioblastoma and CNS tumors
Glioblastoma and CNS tumors PRECEPTORSHIP PROGRAMME IMMUNO-ONCOLOGY Amsterdam, 1 October 2016 Patrick Roth Department of Neurology and Brain Tumor Center University Hospital Zurich Immunology in the CNS
More informationWHO 2016 CNS Tumor Classification Update. DISCLOSURES (Arie Perry, MD) PATTERN RECOGNITION. Arie Perry, M.D. Director, Neuropathology
WHO 2016 CNS Tumor Classification Update Arie Perry, M.D. Director, Neuropathology DISCLOSURES (Arie Perry, MD) I have no financial relationships to disclose. - and - I will not discuss off label use or
More informationCNS pathology Third year medical students. Dr Heyam Awad 2018 Lecture 12: CNS tumours 2/3
CNS pathology Third year medical students Dr Heyam Awad 2018 Lecture 12: CNS tumours 2/3 Pilocytic astrocytoma Relatively benign ( WHO grade 1) Occurs in children and young adults Mostly: in the cerebellum
More informationEsophageal Cancer in Tanzania
Esophageal Cancer in Tanzania Katherine Van Loon, MD, MPH Assistant Clinical Professor Director of Global Oncology Program Helen Diller Family Comprehensive Cancer Center University of California, San
More informationNicholas Szerlip, MD Department of Neurosurgery Wayne State University Karmanos Cancer Institute
Nicholas Szerlip, MD Department of Neurosurgery Wayne State University Karmanos Cancer Institute Many different names (Heregulin, Aria) Found when investigating ligands that activated HER2 (it actually
More informationA clinical perspective on neuropathology and molecular genetics in brain tumors
A clinical perspective on neuropathology and molecular genetics in brain tumors M.J. van den Bent Erasmus MC Cancer Institute Rotterdam, the Netherlands Disclosures Member speakersbureau: MSD Consultancy:
More informationGlioblastoma: Current Treatment Approach 8/20/2018
Glioblastoma: Current Treatment Approach 8/20/2018 Overview What is Glioblastoma? How is it diagnosed How is it treated? Principles of Treatment Surgery, Radiation, Chemotherapy Current Standard of care
More information성균관대학교삼성창원병원신경외과학교실신경종양학 김영준. KNS-MT-03 (April 15, 2015)
성균관대학교삼성창원병원신경외과학교실신경종양학 김영준 INTRODUCTIONS Low grade gliomas (LGG) - heterogeneous group of tumors with astrocytic, oligodendroglial, ependymal, or mixed cellular histology - In adults diffuse, infiltrating
More informationClinical significance of genetic analysis in glioblastoma treatment
Clinical significance of genetic analysis in glioblastoma treatment Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan Koji Yoshimoto Can we get prognostic
More informationPrognostic value of ADC in glioblastoma multiforme and its correlation with survival and MGMT promoter methylation status.
Prognostic value of ADC in glioblastoma multiforme and its correlation with survival and MGMT promoter methylation status. R. Zalazar, M.D. Hernández, M. Páramo, P. Slon, M. Millor Muruzabal, J. Solorzano
More information2015 EUROPEAN CANCER CONGRESS
2015 EUROPEAN CANCER CONGRESS 25-29 September 2015 Vienna, Austria SUMMARY The European Cancer Congress (ECC 2015) combined the 40th European Society for Medical Oncology (ESMO) congress with the 18th
More informationSYSTEMIC MANAGEMENT OF PEDIATRIC PRIMARY BRAIN TUMORS
SYSTEMIC MANAGEMENT OF PEDIATRIC PRIMARY BRAIN TUMORS María E. Echevarría, MD Assistant Professor University of Puerto Rico Medical Sciences Campus DISCLOSURES No disclosures INTRODUCTION Pediatric CNS
More informationAccelerating Translation at Dana-Farber Cancer Institute*
Accelerating Translation at Dana-Farber Cancer Institute* *and our partner institutions February 12, 2013 Edward J Benz JR, MD Dana Farber Cancer Institute 1 2 Academic Structure All Dana-Farber faculty
More informationGeneral: Brain tumors are lesions that have mass effect distorting the normal tissue and often result in increased intracranial pressure.
1 Lecture Objectives Know the histologic features of the most common tumors of the CNS. Know the differences in behavior of the different tumor types. Be aware of the treatment modalities in the various
More informationPredictive Assays in Radiation Therapy
Outline Predictive Assays in Radiation Therapy Radiation Biology Introduction Early predictive assays Recent trends in predictive assays Examples for specific tumors Summary Lecture 4-23-2014 Introduction
More informationImaging of glycolytic metabolism in primary glioblastoma cells with
63 Chapter 5 Imaging of glycolytic metabolism in primary glioblastoma cells with RIMChip 5.1. Introduction Glioblastoma(GBM) is one of the most common brain tumors 1. It is composed of heterogeneous subpopulations
More informationContemporary Classification of Breast Cancer
Contemporary Classification of Breast Cancer Laura C. Collins, M.D. Vice Chair of Anatomic Pathology Professor of Pathology Beth Israel Deaconess Medical Center and Harvard Medical School Boston, MA Outline
More informationUNIVERSITY OF MEDICINE AND PHARMACY CRAIOVA PhD SCHOOL. PhD THESIS
UNIVERSITY OF MEDICINE AND PHARMACY CRAIOVA PhD SCHOOL PhD THESIS THE IMPORTANCE OF TUMOR ANGIOGENESIS IN CEREBRAL TUMOR DIAGNOSIS AND THERAPY ABSTRACT PhD COORDINATOR: Prof. univ. dr. DRICU Anica PhD
More informationAnti-tumor Effects of Activated Human Natural Killer Cells in Orthotopic Human Brain Tumor Models
Anti-tumor Effects of Activated Human Natural Killer Cells in Orthotopic Human Brain Tumor Models William Murphy, PhD Depts. of Dermatology and Internal Medicine Neal Goodwin, PhD Jackson Laboratories
More informationAdvanced treatment in high-grade gliomas
JBUON 2019; 24(2): 424-430 ISSN: 1107-0625, online ISSN: 2241-6293 www.jbuon.com E-mail: editorial_office@jbuon.com REVIEW ARTICLE Advanced treatment in high-grade gliomas Lai Xiong 1 *, Feng Wang 1 *,
More informationIon channels in the pathophysiology and therapeutics of brain tumors
Workshop dipartimentale 2 dicembre 2015 Gruppo di ricerca Fisiopatologia Cellulare e Molecolare Main research Ion channels in the pathophysiology and therapeutics of brain tumors Components: Fabio Franciolini,
More informationTGFβR1 Kinase Inhibitor
TGFβR1 Kinase Inhibitor Galunisertib, LY2157299 H 2 0 Derived from Prud homme GJ 1 ; Flavell RA, et al. 2 Drug Discovery Platform: Cancer Angiogenesis and Tumor Microenvironment/Immuno-Oncology A Phase
More informationIt s s Always Something!
It s s Always Something! New Approaches in Brain Tumor Treatment Virginia Stark-Vance, M.D. When Something Is a Brain Tumor Brain tumors aren t rare: there are over 100,000/yr Most originate as other cancers
More informationDeveloping New Therapies to Treat Glioblastoma
Transcript Details This is a transcript of an educational program accessible on the ReachMD network. Details about the program and additional media formats for the program are accessible by visiting: https://reachmd.com/programs/focus-on-cancer/developing-new-therapies-to-treat-glioblastoma/4077/
More informationNeuro-Oncology. Martin J. van den Bent. Department of Neuro-oncology/Neurology, Erasmus M.C. Cancer Institute, Rotterdam, Netherlands
Neuro-Oncology Neuro-Oncology 16(12), 1570 1574, 2014 doi:10.1093/neuonc/nou297 Advance Access date 29 October 2014 Practice changing mature results of RTOG study 9802: another positive PCV trial makes
More informationAmy Lin, Ph.D. November 14, 2018
PD L1 checkpoint blockade using a single chain variable fragment targeting PD L1 delivered by retroviral replicating vector (Toca 521) enhances anti tumor effect in murine cancer models Amy Lin, Ph.D.
More informationProvocative Questions from a Clinical Perspective
AAPM 2017 Provocative Questions from a Clinical Perspective Glenn Liu, MD Professor of Medicine and Medical Physics Leader, Developmental Therapeutics Program Director, Genitourinary Oncology Research
More informationEpidemiology and outcome research of glioma patients in Southern Switzerland: A population based analysis
Epidemiology and outcome research of glioma patients in Southern Switzerland: A population based analysis G. Pesce 1, A. Bordoni, F. Montanaro, R. Renella 3, A. Richetti 1, D. Boscherini 3, S. Mauri 4,
More informationTargeted Therapeutics for the Treatment of Cancer
Targeted Therapeutics for the Treatment of Cancer Company overview Three promising targeted anti-cancer programs Irreversible pan-erbb inhibitor EGFR/HER2/HER4 inhibitor PARP inhibitor Strategy Focus on
More informationCorporate Medical Policy
Corporate Medical Policy BRAF Gene Variant Testing to Select Melanoma or Glioma Patients File Name: Origination: Last CAP Review: Next CAP Review: Last Review: braf_gene_variant_testing_to_select_melanoma_or_glioma_patients_for_targeted_
More informationResearch Article Isocitrate Dehydrogenase-1 Mutations as Prognostic Biomarker in Glioblastoma Multiforme Patients in West Bohemia
BioMed Research International, Article ID 735659, 5 pages http://dx.doi.org/10.1155/2014/735659 Research Article Isocitrate Dehydrogenase-1 Mutations as Prognostic Biomarker in Glioblastoma Multiforme
More informationCHMP Oncology Working Party Workshop on: Histology Independent Indications in Oncology. Non-clinical models: Tumour Models - Proof of Concept
CHMP Oncology Working Party Workshop on: Histology Independent Indications in Oncology Non-clinical models: Tumour Models - Proof of Concept Edward C. Rosfjord Pfizer Worldwide R. & D. 14 December 2017
More informationmicrornas (mirna) and Biomarkers
micrornas (mirna) and Biomarkers Small RNAs Make Big Splash mirnas & Genome Function Biomarkers in Cancer Future Prospects Javed Khan M.D. National Cancer Institute EORTC-NCI-ASCO November 2007 The Human
More informationChapter 1 Introduction
Chapter 1 Introduction Men think epilepsy divine, merely because they do not understand it. But if they called everything divine which they do not understand, why, there would be no end to divine things.
More informationPI3-Kinase Signaling. Rational Incorporation of Novel Agents into Multimodality Therapy. PI3-kinase. PI3-kinase 5/2/2010
Rational Incorporation of Novel Agents into Multimodality Therapy I3-Kinase Signaling EGF IRS1 I3K EGFR I2 I3 TEN Rictor GßL AKT RAS40 Survival Raptor GßL Daphne Haas-Kogan UCSF Annual Course April 30-May
More informationDifferential Connexin Function Enhances Self-Renewal in Glioblastoma
CSU ID: 2558414 Name: Sonal Patel Differential Connexin Function Enhances Self-Renewal in Glioblastoma Cancer is one of the most common disease in the US with more than a million people affected every
More information