Welke bijdrage levert ctdna analyse bij de behandeling van longkanker
|
|
|
- Evelyn Peters
- 5 years ago
- Views:
Transcription
1 Welke bijdrage levert ctdna analyse bij de behandeling van longkanker Liquid biopsies & Lung cancer
2 Disclosures: (Potential) conflict of interest Sponsorship or research funding Fee or other (financial payment) AstraZeneca, BMS, Merck Serono, MSD, Novartis, Pfizer, Roche, Roche Diagnostics, AstraZeneca, Pfizer, BMS, Roche, MSD, Abbvie, Novartis
3 Unmet clinical need For metastasized disease Predictive non-invasive biomarkers for response to therapy To develop early response tools For locally advanced or early stage disease Minimal residual disease Screening Now Future
4 Take home messages NU: CtDNA diagnostiek is zinvol en soms cruciaal MORGEN: CtDNA NGS panel CtDNA gaat beschikbaar komen voor beoordeling respons / ziekteactiviteit TOEKOMST Minimal residual disease biomarkers Liquid biopsies bij longkankerscreening
5 Treatment algorithm NSCLC IV Current diagnostic strategy (2019) NSCLC IV Immunotherapy 1 st line: - 50: Pembrolizumab - 1% Pembrolizumab - All comers (or PDL1<1%?) - Pembrolizumab /Pem/Cispl - Atezolizumab/Ca/T/Bev 2 nd line: - All comers: - Nivolumab - Atezolizumab - 50: Pembrolizumab PDL1 Molecular analysis PS 0/1 TTF1/P63 Histology-driven chemotherapy EGFR BRAF ALK ROS PDL1 <1%? Contra-indication for immunotherapy Targeted therapy - Erlotinib, Gefitinib, Afatinib, Dacomitinib - Osimertinib - Trametinib and dafrafenib - Crizotinib, Ceritinib, Alectinib, Brigatinib, Lorlatinib Off label: MET Targets to be expected: HER2, RET, NTRK, MEK1,..
6
7 Diagnostische waarde Liquid Biopsy Merker, Oxnard, JCO 2017
8 NSCLC, SCC, female 48yr 12/2015
9 ctdna-ngs
10 Insufficient tissue ctdna, NGS - Guardant 360 (70 gene panel) - 93patients with unsufficient tissue - NSCLC St IV, Adeno (53% Rx naïve) - 89% ctdna+ - 13days turn around time Mitogenic drivers VUS 10% 9% 24% 57% 14% (n=13) EGFR, ROS, BRAF, MET 20% (19) KRAS Zugazogoitia et al, ASCO 2018
11 Commercial Next Generation Sequencing Liquid Biopsy Tests Presented By Sai-Hong Ou at 2018 ASCO Annual Meeting
12 Liquid Biopsy to Determine Tumor Mutation Burden (TMB)
13 ctdna Pro s Niet invasief Ook indien geen biopten beschikbaar Beter voor FU ziekte Kansen: Assessing MRD Screening? Con s Minder genen Nog geen gevalideerde test voor: Fusie detectie TMB NGS Beperkte klinische date Vals positief agv clonale hematopoiesis (CHIP)
14 Slide 4 Presented By Sai-Hong Ou at 2018 ASCO Annual Meeting
15 Flowchart gebruik liquid biopsies-cfdna
16 Alleen interessant voor bloed?
17 Wakelee HA et al. ASCO annual meeting 2016 cfdna Urine
18 Conclusions cfdna Liquid biopsies Ready for clinical use 18
19 ctdna / protein monitoring tijdens de behandeling Non-invasive Genotyping Tumor burden Local tx (eg radiotherapy) Systemic tx (eg TKI) Development sec. resistancy 2 nd line Systemic tx Time
20 Early response biomarkers ctdna - Immunotherapy Agreement ctdna and radiographic response Timing ctdna and radiographic response Goldberg CCR 2018
21 Minimal residual disease
22 Post-operatief ctdna voorspelt NSCLC relapse TracerX consortium Nature 2017
23 N=37( Stage I-III) NGS plasma Capp Seq Sampling weeks to months following Rx N=23 ( 18 x surgery, 5 x radiotherapy) NGS plasma, Guardant360 (70genes) Sampling weeks to months following Rx Chaudury, Canc Discov 2018;Zugazagoitia, ASCO 2018
24 cfdna for screening for lungcancer?
25 Slide 4 Presented By Geoffrey Oxnard at 2018 ASCO Annual Meeting
26 CCGA is a Prospective Longitudinal Cohort Study Designed for Early Cancer Detection: First Training and Test Set Analyses Presented By Geoffrey Oxnard at 2018 ASCO Annual Meeting
27 Consistent Biological Signal Across Lung Cancer Stages in Training and Test Sets Presented By Geoffrey Oxnard at 2018 ASCO Annual Meeting
28 Take home messages NU: CtDNA diagnostiek is zinvol en soms cruciaal Serum tumormarkers kunnen nu gebruikt worden ivm beoordeling respons MORGEN: CtDNA NGS panel komen eraan CtDNA gaat beschikbaar komen voor beoordeling respons / ziekteactiviteit TOEKOMST Betrouwbare minimal residual ziekte biomarkers komen eraan Liquid biopsies gaan een rol spelen bij longkankerscreening
29 29 Questions?
NCCN Non-Small Cell Lung Cancer V Meeting June 15, 2018
Guideline Page and Request Illumina Inc. requesting to replace Testing should be conducted as part of broad molecular profiling with Consider NGS-based assays that include EGFR, ALK, ROS1, and BRAF as
OTRAS TERAPIAS BIOLÓGICAS EN CPNM: Selección y Secuencia Óptima del Tratamiento
OTRAS TERAPIAS BIOLÓGICAS EN CPNM: Selección y Secuencia Óptima del Tratamiento Dolores Isla Servicio de Oncología Médica HCU Lozano Besa de Zaragoza 2008 Selection Factors in Advanced NSCLC ( 8y ago)
Recent Advances in Lung Cancer: Updates from ASCO 2017
Recent Advances in Lung Cancer: Updates from ASCO 2017 Charu Aggarwal, MD, MPH Assistant Professor of Medicine Division of Hematology-Oncology Abramson Cancer Center University of Pennsylvania 6/15/2017
Tissue or Liquid Biopsy? ~For Diagnosis, Monitoring and Early detection of Resistance~
16 th Dec. 2016. ESMO Preceptorship Program Non-Small-Cell Lung Cancer @Singapore Tissue or Liquid Biopsy? ~For Diagnosis, Monitoring and Early detection of Resistance~ Research Institute for Disease of
Personalized Treatment Approaches for Lung Cancer
Personalized Treatment Approaches for Lung Cancer California Thoracic Society 2018 Annual Carmel Conference January 27, 2018 Matthew Gubens, MD, MS Associate Professor of Medicine Chair, Thoracic Oncology
Targeted therapy in NSCLC: do we progress? Prof. Dr. V. Surmont. Masterclass 27 september 2018
Targeted therapy in NSCLC: do we progress? Prof. Dr. V. Surmont Masterclass 27 september 2018 Outline Introduction EGFR TKI ALK TKI TKI for uncommon driver mutations Take home messages The promise of
Lung Cancer Update 2016 BAONS Oncology Care Update
Lung Cancer Update 2016 BAONS Oncology Care Update Matthew Gubens, MD, MS Assistant Professor Chair, Thoracic Oncology Site Committee UCSF Helen Diller Family Comprehensive Cancer Center Disclosures Consulting
Personalized Therapies for Lung Cancer. Questions & Answers
Personalized Therapies for Lung Cancer Questions & Answers What are Personalized Therapies for lung cancer? Like people, no two lung cancer tumors are the same. Personalized medicine (also known as precision
Nieuwe targets en cfdna
Nieuwe targets en cfdna dr. A.J. van der Wekken Universitair Medische Centrum Groningen Leek meeting 2017 Disclosure Advisory board: Lilly Boehringer-Ingelheim Pfizer AstraZeneca MSD Lectures: Lilly Boehringer-Ingelheim
Molecular Targets in Lung Cancer
Molecular Targets in Lung Cancer Robert Ramirez, DO, FACP Thoracic and Neuroendocrine Oncology November 18 th, 2016 Disclosures Consulting and speaker fees for Ipsen Pharmaceuticals, AstraZeneca and Merck
Case Studies. Ravi Salgia, MD, PhD
Case Studies Ravi Salgia, MD, PhD Professor and Arthur & Rosalie Kaplan Chair Medical Oncology and Therapeutics Research Associate Director for Clinical Sciences Research City of Hope 04-21-2018 Objectives
Joachim Aerts Erasmus MC Rotterdam, Netherlands. Drawing the map: molecular characterization of NSCLC
Joachim Aerts Erasmus MC Rotterdam, Netherlands Drawing the map: molecular characterization of NSCLC Disclosures Honoraria for advisory board/consultancy/speakers fee Eli Lilly Roche Boehringer Ingelheim
Lung Cancer Genetics: Common Mutations and How to Treat Them David J. Kwiatkowski, MD, PhD. Mount Carrigain 2/4/17
Lung Cancer Genetics: Common Mutations and How to Treat Them David J. Kwiatkowski, MD, PhD Mount Carrigain 2/4/17 Histology Adenocarcinoma: Mixed subtype, acinar, papillary, solid, micropapillary, lepidic
Advances in Pathology and molecular biology of lung cancer. Lukas Bubendorf Pathologie
Advances in Pathology and molecular biology of lung cancer Lukas Bubendorf Pathologie Agenda The revolution of predictive markers Liquid biopsies PD-L1 Molecular subtypes (non-squamous NSCLC) Tsao AS et
PROGRESSION AFTER THIRD GENERATION TKI
PROGRESSION AFTER THIRD GENERATION TKI What next? National Cancer Center Hospital Yuichiro Ohe, MD Name of lead presenter Yuichiro Ohe employee of company and/or profit-making organization adviser of company
NCCN Non Small Cell Lung Cancer V Meeting July 8, 2016
NSCL 3 Submission from Myriad requesting the following statement to be listed as an additional high risk factor in footnote p : For lung ADC, a highrisk 46 gene molecular prognostic score determined by
Targeted Therapy for NSCLC: EGFR and ALK Fadlo R. Khuri, MD
EGFR and ALK Fadlo R. Khuri, MD President, American University of Beirut Professor of Medicine July 26, 2018 A great year end! Targeted Therapy for NSCLC: Evolving Landscape of Lung Adenocarcinoma NSCLC
Targeted therapies for advanced non-small cell lung cancer. Tom Stinchcombe Duke Cancer Insitute
Targeted therapies for advanced non-small cell lung cancer Tom Stinchcombe Duke Cancer Insitute Topics ALK rearranged NSCLC ROS1 rearranged NSCLC EGFR mutation: exon 19/exon 21 L858R and uncommon mutations
Practice changing studies in lung cancer 2017
1 Practice changing studies in lung cancer 2017 Rolf Stahel University Hospital of Zürich Cape Town, February 16, 2018 DISCLOSURE OF INTEREST Consultant or Advisory Role in the last two years I have received
Incorporating Immunotherapy into the treatment of NSCLC
Incorporating Immunotherapy into the treatment of NSCLC Suresh S. Ramalingam, MD Roberto C. Goizueta Chair for Cancer Research Assistant Dean for Cancer Research Deputy Director, Winship Cancer Institute
Plotting the course: optimizing treatment strategies in patients with advanced adenocarcinoma
Pieter E. Postmus University of Liverpool Liverpool, UK Plotting the course: optimizing treatment strategies in patients with advanced adenocarcinoma Disclosures Advisor Bristol-Myers Squibb AstraZeneca
Corporate Medical Policy
Corporate Medical Policy Molecular Analysis for Targeted Therapy for Non-Small Cell Lung File Name: Origination: Last CAP Review: Next CAP Review: Last Review: molecular_analysis_for_targeted_therapy_for_non_small_cell_lung_cancer
Lung Cancer Case. Since the patient was symptomatic, a targeted panel was sent. ALK FISH returned in 2 days and was positive.
Lung Cancer Case Jonathan Riess, M.D. M.S. Assistant Professor of Medicine University of California Davis School of Medicine UC Davis Comprehensive Cancer Center 63 year-old woman, never smoker, presents
Targeted/Immunotherapy & Molecular Profiling State-of-the-art in Cancer Care
Targeted/Immunotherapy & Molecular Profiling State-of-the-art in Cancer Care Manmeet Ahluwalia, MD, FACP Miller Family Endowed Chair in Neuro-Oncology Director Brain Metastasis Research Program Cleveland
Diagnostic with alternative sample types (liquid biopsy)
MOLECULAR DIAGNOSTICS OF EGFR AND T790M MUTATIONS CHALLENGES AND SOLUTIONS Diagnostic with alternative sample types (liquid biopsy) James CH Yang, MD, PhD Director, Professor, Graduate Institute of Oncology
State of the Art Treatment of Lung Cancer Ravi Salgia, MD, PhD
State of the Art Treatment of Lung Cancer Ravi Salgia, MD, PhD Professor and Chair Arthur & Rosalie Kaplan Chair Medical Oncology and Therapeutics Research Nothing to disclose DISCLOSURE Objectives Lung
LUNG CANCER IN FOCUS. ALK Inhibitors in Non Small Cell Lung Cancer: How Many Are Needed and How Should They Be Sequenced?
LUNG CANCER IN FOCUS Current Developments in the Management of Section Editor: Mark A. Socinski, MD ALK Inhibitors in Non Small Cell : How Many Are Needed and How Should They Be Sequenced? Alice T. Shaw,
Molecular Testing in Lung Cancer
Molecular Testing in Lung Cancer Pimpin Incharoen, M.D. Assistant Professor, Thoracic Pathology Department of Pathology, Ramathibodi Hospital Genetic alterations in lung cancer Source: Khono et al, Trans
CURRENT STANDARD OF CARE OF LUNG CANCER. Maroun El-Khoury, MD Consultant Oncologist/Hematologist American Hospital Dubai President of Medical staff
CURRENT STANDARD OF CARE OF LUNG CANCER Maroun El-Khoury, MD Consultant Oncologist/Hematologist American Hospital Dubai President of Medical staff Biopsy: Establish Diagnosis, Determine Histologic Subtype,
Aggiornamenti in oncologia tra ricerca e clinica: Carcinoma del polmone
Convegno Interregionale AIOM Lombardia, Liguria, Piemonte e Valle D Aosta Coniugare innovazione, sostenibilità e continuità di cura in oncologia: il ruolo delle Reti regionali Milano, 19 Novembre 2016
Non-Small Cell Lung Cancer:
Non-Small Cell Lung Cancer: Where We Are Today Sila Shalhoub, PharmD PGY2 Oncology Pharmacy Resident Shalhoub.Sila@mayo.edu Pharmacy Grand Rounds September 26, 2017 2017 MFMER slide-1 Objectives Identify
Integration of Genomics Into Clinical Pathways. Precision Medicine and Decision Support
Integration of Genomics Into Clinical Pathways Precision Medicine and Decision Support Faculty Andrew Hertler, MD, FACP Chief Medical Officer New Century Health Andrew Hertler, MD, FACP is employed by
Qué hemos aprendido hasta hoy? What have we learned so far?
Qué hemos aprendido hasta hoy? What have we learned so far? Luís Costa Hospital de Santa Maria & Instituto de Medicina Molecular Faculdade de Medicina de Lisboa Disclosures Research Grants: Amgen; Novartis;
Circulating Tumor DNA for Management of Non-Small-Cell Lung Cancer (Liquid Biopsy)
Circulating Tumor DNA for Management of Non-Small-Cell Lung Cancer (Liquid Biopsy) Policy Number: 2.04.143 Last Review: 1/2019 Origination: 1/2018 Next Review: 1/2020 Policy Blue Cross and Blue Shield
Biomarcatori per la immunoterapia: cosa e come cercare Paolo Graziano
Biomarcatori per la immunoterapia: cosa e come cercare Paolo Graziano Unit of Pathology Fondazione IRCCS Casa Sollievo della Sofferenza San Giovanni Rotondo, Foggia,Italy p.graziano@operapadrepio.it Disclosure
NSCLC 2 nd and further line therapies. Egbert F. Smit MD PhD. Dept. Thoracic Oncology, Netherlands Cancer Institute
NSCLC 2 nd and further line therapies Egbert F. Smit MD PhD. Dept. Thoracic Oncology, Netherlands Cancer Institute e.smit@nki.nl ESMO Guidelines 2016: Treatment of Stage IV nonsquamous NSCLC at progression
Role of the pathologist in the diagnosis and mutational analysis of lung cancer Professor J R Gosney
Role of the pathologist in the diagnosis and mutational analysis of lung cancer Professor J R Gosney Consultant Thoracic Pathologist Royal Liverpool University Hospital Disclosure JRG is a paid advisor
biomarker testing What you need to know about... LUNG CANCER TREATMENTS
LUNG CANCER TREATMENTS What you need to know about... biomarker testing Copyright 2018 LUNGevity Foundation All rights reserved. No part of this publication may be reproduced, distributed, or transmitted
Drug Resistance in ALK- and ROS1-Rearranged Lung Cancers. Alice T. Shaw, MD PhD Director, Center for Thoracic Cancers September 16, 2017
Drug Resistance in ALK- and ROS1-Rearranged Lung Cancers Alice T. Shaw, MD PhD Director, Center for Thoracic Cancers September 16, 2017 ALK and ROS1 are Related Tyrosine Kinases, and Both are Targeted
Corporate Medical Policy
Corporate Medical Policy Proteomic Testing for Targeted Therapy in Non-Small Cell Lung File Name: Origination: Last CAP Review: Next CAP Review: Last Review: proteomic_testing_for_targeted_therapy_in_non_small_cell_lung_cancer
MP Circulating Tumor DNA Management of Non-Small-Cell Lung Cancer (Liquid Biopsy)
Medical Policy BCBSA Ref. Policy: 2.04.143 Last Review: 10/18/2018 Effective Date: 10/18/2018 Section: Medicine Related Policies 2.04.121 Miscellaneous Genetic and Molecular Diagnostic Tests 2.04.45 Molecular
The oncologist s point of view: the promise and challenges of increasing options for targeted therapies in NSCLC
The oncologist s point of view: the promise and challenges of increasing options for targeted therapies in NSCLC Egbert F. Smit Department of Thoracic Oncology, Netherlands Cancer Institute, and Department
Activity of osimertinib and the selective RET inhibitor BLU-667 in an EGFR-mutant patient with acquired RET rearrangement.
Activity of osimertinib and the selective RET inhibitor in an EGFR-mutant patient with acquired RET rearrangement. Z Piotrowska 1, H Isozaki 1, JK Lennerz 1, S Digumarthy 1, JF Gainor 1, N Marcoux 1, M
Recent Advances in Lung Cancer: Updates from ASCO Updates from ESMO, AACR and ASCO
Recent Advances in Lung Cancer: Updates from ASCO 2018 Updates from ESMO, AACR and ASCO Charu Aggarwal, MD, MPH Assistant Professor of Medicine Division of Hematology-Oncology Abramson Cancer Center University
NGS in Lung Cancer Cytology
Institute of Pathology NGS in Lung Cancer Cytology Spasenija Savic University Hospital Basel, Switzerland Disclosures Speakers honoraria and advisory boards: Astra Zeneca, BMS, MSD, Novartis, Pfizer, Roche
Medical Policy An independent licensee of the Blue Cross Blue Shield Association
Circulating Tumor DNA Management of Non-Small-Cell Lung Cancer (Liquid Biopsy) Page 1 of 36 Medical Policy An independent licensee of the Blue Cross Blue Shield Association Title: Circulating Tumor DNA
Targeted Cancer Therapies
Targeted Cancer Therapies Primary Care Training Programme 14 th February 2018 Sin Chong Lau Consultant in Medical Oncology Financial Disclosure Honoraria: Amgen, Pfizer, Roche, Sanofi, Servier Meetings:
REPORT ASCO 2018 CHICAGO: RESPIRATORY ONCOLOGY Johan Vansteenkiste / Christophe Dooms, Univ. Hospital KU Leuven and Leuven Lung Cancer Group
1 REPORT ASCO 2018 CHICAGO: RESPIRATORY ONCOLOGY Johan Vansteenkiste / Christophe Dooms, Univ. Hospital KU Leuven and Leuven Lung Cancer Group OUR 10 MESSAGE HIGHLIGHTS 1/ Advanced NSCLC 1 st line: IO
Liquid biopsy: the experience of real life case studies
Liquid biopsy: the experience of real life case studies 10 th September 2018 Beatriz Bellosillo Servicio de Anatomía Patológica Hospital del Mar, Barcelona Agenda Introduction Experience in colorectal
NSCLC: Terapia medica nella fase avanzata. Paolo Bidoli S.C. Oncologia Medica H S. Gerardo Monza
NSCLC: Terapia medica nella fase avanzata Paolo Bidoli S.C. Oncologia Medica H S. Gerardo Monza First-line Second-line Third-line Not approved CT AND SILENT APPROVAL Docetaxel 1999 Paclitaxel Gemcitabine
Lung Cancer Update on Pathology Zhaolin Xu, MD, FRCPC, FCAP
Lung Cancer Update on Pathology Zhaolin Xu, MD, FRCPC, FCAP Professor, Dept of Pathology, Dalhousie University Pulmonary Pathologist and Cytopathologist, QEII HSC Senior Scientist, Beatrice Hunter Cancer
Lung Cancer in Paul Wheatley-Price BSc, MBChB, MRCP (UK), MD
Lung Cancer in 2015 Paul Wheatley-Price BSc, MBChB, MRCP (UK), MD Assistant Professor, Division of Medical Oncology, Department of Medicine, University of Ottawa 1 Disclosures Honorarium for advisory boards,
MICROSCOPY PREDICTIVE PROFILING
Immunomodulatory therapy in NSCLC: a year into clinical practice Professor J R Gosney Consultant Thoracic Pathologist Royal Liverpool University Hospital Disclosure JRG is a paid advisor to and speaker
Recent Advances in Lung Cancer: Updates from ASCO 2016
Recent Advances in Lung Cancer: Updates from ASCO 2016 Charu Aggarwal, MD, MPH Assistant Professor of Medicine Division of Hematology-Oncology Abramson Cancer Center University of Pennsylvania 6/23/2016
TARGETED THERAPY FOR LUNG CANCER. Patient and Caregiver Guide
TARGETED THERAPY FOR LUNG CANCER Patient and Caregiver Guide TARGETED THERAPY FOR LUNG CANCER Patient and Caregiver Guide TABLE OF CONTENTS Why Targeted Therapy?...2 Lung Cancer Basics...2 Changes in
LUNG CANCER. pathology & molecular biology. Izidor Kern University Clinic Golnik, Slovenia
LUNG CANCER pathology & molecular biology Izidor Kern University Clinic Golnik, Slovenia 1 Pathology and epidemiology Small biopsy & cytology SCLC 14% NSCC NOS 4% 70% 60% 50% 63% 62% 61% 62% 59% 54% 51%
Dr. Andres Wiernik. Lung Cancer
Dr. Andres Wiernik Lung Cancer Lung Cancer Facts - Demographics World Incidence: 1 8 million / year World Mortality: 1 6 million / year 5-year survival rates vary from 4 17% depending on stage and regional
Medical Treatment of Advanced Lung Cancer
Medical Treatment of Advanced Lung Cancer Oncology for Scientists April 26, 2018 Edwin Yau, MD., Ph.D. Assistant Professor of Oncology Department of Medicine Department of Cancer Genetics and Genomics
3/13/2018. Case 1. Multidisciplinary Management of Cancers Thoracic Oncology Tumor Board
Multidisciplinary Management of Cancers Thoracic Oncology Tumor Board Matthew Gubens, MD MS, UC San Francisco, Chair Julia Rotow, MD, UC San Francisco, Fellow Colin Blakely, MD PhD, UC San Francisco GigI
A Look at the Near Future of Lung Cancer Treatment
A Look at the Near Future of Lung Cancer Treatment Dates of certification: May 31, 2016, to May 31, 2017 Medium: Print with online posttest, evaluation, and request for credit The American Journal of Hematology/Oncology
Other Driver Mutations: cmet, B-RAF, RET, NTRK
Other Driver Mutations: cmet, B-RAF, RET, NTRK Luis E. Raez MD FACP FCCP Chief of Hematology/Oncology and Medical Director, Memorial Cancer Institute Clinical Professor of Medicine Herbert Wertheim College
Management Strategies for Lung Cancer Sensitive or Resistant to EGRF Inhibitors
Management Strategies for Lung Cancer Sensitive or Resistant to EGRF Inhibitors Conor E. Steuer, MD Assistant Professor The Winship Cancer Institute of Emory University July 27, 2017 1 Lung Cancer One
Giorgio V. Scagliotti Università di Torino Dipartimento di Oncologia
Giorgio V. Scagliotti Università di Torino Dipartimento di Oncologia giorgio.scagliotti@unito.it Politi K & Herbst R. Clin. Cancer Res. 2015; 21:2213 Breast Colorectal Gastric/GE Junction Tumor Type Head
Molecular Testing Updates. Karen Rasmussen, PhD, FACMG Clinical Molecular Genetics Spectrum Medical Group, Pathology Division Portland, Maine
Molecular Testing Updates Karen Rasmussen, PhD, FACMG Clinical Molecular Genetics Spectrum Medical Group, Pathology Division Portland, Maine Keeping Up with Predictive Molecular Testing in Oncology: Technical
GENETIC TESTING FOR TARGETED THERAPY FOR NON-SMALL CELL LUNG CANCER (NSCLC)
CANCER (NSCLC) Non-Discrimination Statement and Multi-Language Interpreter Services information are located at the end of this document. Coverage for services, procedures, medical devices and drugs are
Personalized Genetics
Personalized Genetics Understanding Your Genetic Test Results Tracey Evans, MD September 29, 2017 Genetics 101 Punnett Square Genetic Pedigree 2 Genetics 101 Punnett Square Genetic Pedigree 3 It s not
What is new in Immunotherapy, Biomarkers and Side Effects
What is new in Immunotherapy, Biomarkers and Side Effects Prof Dr Christian Rolfo, MD, PhD, MBA Director of Phase I Early Clinical Trials Unit Director of Clinical Trial Management Program Oncology Department
Reimbursement Perspectives on Precision Medicine. CADTH Symposium Ferg Mills, Dr. Natasha Leighl, Dr. David Shum, Olaf Koester
Reimbursement Perspectives on Precision Medicine CADTH Symposium 2017 Ferg Mills, Dr. Natasha Leighl, Dr. David Shum, Olaf Koester Perspectives Natasha Leighl MD MMSc FRCPC Professor of Medicine, University
BRAIN METS IN 2018: ANY CLOSER TO THE END OF A LONG AND WINDING ROAD?
BRAIN METS IN 2018: ANY CLOSER TO THE END OF A LONG AND WINDING ROAD? M.J. van den Bent The Brain Tumor Center at Erasmus MC Cancer Center Rotterdam, the Netherlands Molecular targets in primary cancers
Clinical Updates and Issues: Advanced Non-Small Cell Lung Cancer
Clinical Updates and Issues: Advanced Non-Small Cell Lung Cancer Tracy Ruegg, MSN, ARNP, AOCN Miami Cancer Institute formerly of The Ohio State University Comprehensive Cancer Center James Cancer Hospital
ASCP Immuno-Oncology Scientific Updates Liquid Biopsies: Current Limitations and Potential Applications
ASCP Scientific Updates: Liquid Biopsies: Current Limitations and Potential Applications December 2018 Faculty Alexander J Lazar MD, PhD Professor Departments of Pathology, Genomic Medicine, & Translational
Quale sequenza terapeutica nella malattia EGFR+
Trattamento della malattia avanzata oncogene-addicted Quale sequenza terapeutica nella malattia EGFR+ Chiara Bennati AUSL della Romagna Ravenna, Italy A matter of fact Outline Can we improve PFS/OS with
May 9, Dr. James Almas Medical Director MolDX 17 Technology Circle AG-315 Columbia, SC Dear Dr. Almas:
May 9, 2018 Dr. James Almas Medical Director MolDX 17 Technology Circle AG-315 Columbia, SC 29202 Dear Dr. Almas: On behalf of LUNGevity Foundation, the nation s preeminent lung cancer nonprofit that funds
Liquid biopsy in lung cancer: The EGFR paradigm
Liquid biopsy in lung cancer: The EGFR paradigm Lynette M. Sholl, M.D. Brigham and Women s Hospital Dana Farber Cancer Institute Department of Pathology Boston, MA Disclosure of Relevant Financial Relationships
Keytruda (pembrolizumab)
Keytruda (pembrolizumab) Line(s) of Business: HMO; PPO; QUEST Integration Akamai Advantage Original Effective Date: 10/01/2015 Current Effective Date: 07/24/2017TBD03/01/2018 POLICY A. INDICATIONS The
Circulating Tumor DNA in GIST and its Implications on Treatment
Circulating Tumor DNA in GIST and its Implications on Treatment October 2 nd 2017 Dr. Ciara Kelly Assistant Attending Physician Sarcoma Medical Oncology Service Objectives Background Liquid biopsy & ctdna
State of the Art in Molecular Testing and Current Diagnostic Challenges
State of the Art in Molecular Testing and Current Diagnostic Challenges. 2017 Conversations in Oncology in Shanghai, China Mike Zhu, MD/PhD Amoy Diagnostics Co., Ltd BI Symposium Headline Update on molecular
Medical Policy. MP Proteomic Testing for Targeted Systemic in Non-Small-Cell Lung Cancer
Medical Policy MP 2.04.125 Proteomic Testing for Targeted Systemic in Non-Small-Cell Lung Cancer BCBSA Ref. Policy: 2.04.125 Last Review: 11/15/2018 Effective Date: 11/15/2018 Section: Medicine Related
Proteomic Testing for Systemic Therapy in Non-Small Cell Lung Cancer
Proteomic Testing for Systemic Therapy in Non-Small Cell Lung Cancer Policy Number: 2.04.125 Last Review: 6/2018 Origination: 12/2014 Next Review: 12/2018 Policy Blue Cross and Blue Shield of Kansas City
Special Thanks! 10/5/2018. Page 1
Disclaimer This slide deck in its original and unaltered format is for educational purposes. All materials contained herein reflect the views of the faculty, and not those of Creative Educational Concepts,
MANEJO ACTUAL DEL PACIENTE CON CPNM CON REORDENACIONES ALK/ROS O MUTACIONES EN EGFR Rosario García Campelo Complejo Hospitalario Universitario A
MANEJO ACTUAL DEL PACIENTE CON CPNM CON REORDENACIONES ALK/ROS O MUTACIONES EN EGFR Rosario García Campelo Complejo Hospitalario Universitario A Coruña The seventies IMAGINE The eighties The Ninety 2000
Optimum Sequencing of EGFR targeted therapy in NSCLC. Dr. Sema SEZGİN GÖKSU Akdeniz Univercity, Antalya, Turkey
Optimum Sequencing of EGFR targeted therapy in NSCLC Dr. Sema SEZGİN GÖKSU Akdeniz Univercity, Antalya, Turkey Lung cancer NSCLC SCLC adeno squamous EGFR ALK ROS1 BRAF HER2 KRAS EGFR Transl Lung Cancer
Updates in Lung Cancer
Updates in Lung Cancer J. Tanner Ringley, PharmD, BCOP, CPP Levine Cancer Institute Learning Objectives: Discuss incorporation of liquid biopsies into practice and interpretation of immunotherapy biomarker
Updates in Lung Cancer. J. Tanner Ringley, PharmD, BCOP, CPP Levine Cancer Institute
Updates in Lung Cancer J. Tanner Ringley, PharmD, BCOP, CPP Levine Cancer Institute Learning Objectives: Discuss incorporation of liquid biopsies into practice and interpretation of immunotherapy biomarker
AFATINIB FOLLOWED BY OSIMERTINIB IN REAL-WORLD PATIENTS WITH EGFR MUTATION-POSITIVE NSCLC: AN OBSERVATIONAL STUDY
AFATINIB FOLLOWED BY OSIMERTINIB IN REAL-WORLD PATIENTS WITH EGFR MUTATION-POSITIVE NSCLC: AN OBSERVATIONAL STUDY Maximilian J. Hochmair, 1 Alessandro Morabito, 2 Desiree Hao, 3 Cheng-Ta Yang, 4 Ross A.
Impact of Targeted/Immunotherapy on Gamma Knife Radiosurgery
Impact of Targeted/Immunotherapy on Gamma Knife Radiosurgery Veronica Chiang, MD Yale University Department of Neurosurgery IGKRF Scientific Session University of Pennsylvania, Philadelphia June 23-24,
Leading the Way to Precision Care: Molecular Diagnostics and Therapeutics in Lung Cancers. Mark G Kris, MD Memorial Sloan Kettering New Amsterdam USA
Leading the Way to Precision Care: Molecular Diagnostics and Therapeutics in Lung Cancers Mark G Kris, MD Memorial Sloan Kettering New Amsterdam USA Molecular Therapeutics in Lung Cancers Financial Disclosures
Overview of Biomarker Development for Immune PD-1/L1 Checkpoint Blockade
Overview of Biomarker Development for Immune PD-1/L1 Checkpoint Blockade David L. Rimm MD-PhD Professor Departments of Pathology and Medicine (Oncology) Director, Yale Pathology Tissue Services Disclosures
REFERENCE CODE GDHC207DFR PUBLICAT ION DATE JUNE 2013 GILOTRIF (NON-SMALL CELL LUNG CANCER) FORECAST AND MARKET ANALYSIS TO 2022
REFERENCE CODE GDHC207DFR PUBLICAT ION DATE JUNE 2013 GILOTRIF (NON-SMALL CELL LUNG CANCER) GILOTRIF (NON-SMALL CELL LUNG CANCER) - Executive Summary Gilotrif: Key Metrics in NSCLC Markets 2022 Gilotrif
Resistances to EGFR tyrosine kinase inhibitors in lung cancer how to routinely track them in a molecular pathology laboratory?
Review Article Resistances to EGFR tyrosine kinase inhibitors in lung cancer how to routinely track them in a molecular pathology laboratory? Véronique Hofman 1,2,3, Paul Hofman 1,2,3 1 Laboratory of Clinical
INNOVATION IN LUNG CANCER MANAGEMENT. Federico Cappuzzo Department of Oncology-Hematology, AUSL della Romagna, Ravenna, Italy
INNOVATION IN LUNG CANCER MANAGEMENT Federico Cappuzzo Department of Oncology-Hematology, AUSL della Romagna, Ravenna, Italy FIRST-LINE THERAPY FOR METASTATIC NSCLC IN 216 Stratification for EGFR, ALK
Squamous Cell NSCLC: Differentiating Between Progression and Pseudoprogression
Squamous Cell NSCLC: Differentiating Between Progression and Pseudoprogression David R. Spigel, M.D. Program Director, Lung Cancer Research Sarah Cannon Research Institute Nashville, TN Case of NR: Initial
PAVING THE PATH TO PRECISION MEDICINE IN NSCLC
PAVING THE PATH TO PRECISION MEDICINE IN NSCLC Using Biomarkers to Determine Treatment Course Disclaimer This slide deck in its original and unaltered format is for educational purposes. All materials
Molecular Pathology and Lung Cancer. A. John Iafrate MD-PhD Department of Pathology Massachusetts General Hospital Boston, MA
Molecular Pathology and Lung Cancer A. John Iafrate MD-PhD Department of Pathology Massachusetts General Hospital Boston, MA aiafrate@partners.org Disclosures Preliminary patent application NGS AMP Fusion
Multi-drug, genetic-marker-directed, non-comparative, multi-centre, multi-arm phase II trial in non-small cell lung cancer
Multi-drug, genetic-marker-directed, non-comparative, multi-centre, multi-arm phase II trial in non-small cell lung cancer Sponsor: University of Birmingham Chief Investigator: Gary Middleton Chief Biostatistician:
Medical Policy An independent licensee of the Blue Cross Blue Shield Association
Proteomic Testing for Systemic Therapy in Non-Small-Cell Lung Cancer Page 1 of 43 Medical Policy An independent licensee of the Blue Cross Blue Shield Association Title: Proteomic Testing for Systemic
14,30 18,20. II Sessione. Moderatori: Giovanni Apolone, Roberto Labianca
14,30 18,20 II Sessione Moderatori: Giovanni Apolone, Roberto Labianca 15,10 15,30 Ca polmonare (never smokers): attualità e prospettive di ricerca Giulio Metro Ca polmonare (never smokers): attualità
Medical Policy An independent licensee of the Blue Cross Blue Shield Association
Proteomic Testing for Systemic Therapy in Non-Small-Cell Lung Cancer Page 1 of 41 Medical Policy An independent licensee of the Blue Cross Blue Shield Association Title: Proteomic Testing for Systemic
Take home message. Emilio Bria. II SESSIONE: Immunoterapia nel tumore del polmone
II SESSIONE: Immunoterapia nel tumore del polmone Take home message Emilio Bria Oncologia, Dipart. di Medicina, Università di Verona, Az. Osp. Univ. Int., Verona emilio.bria@univr.it Roma, 28 Marzo 2017
Targeting Acquired Resistance to EGFR Kinase Inhibitors: Beyond T790M Mutation
Targeting Acquired Resistance to EGFR Kinase Inhibitors: Beyond T790M Mutation James Chih-Hsin Yang, MD, PhD National Taiwan University Hospital National Taiwan University Cancer Center Taipei, Taiwan