INMUNOTERAPIA II. Dra. Virginia Calvo
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1 INMUNOTERAPIA II Dra. Virginia Calvo
2 LBA53. IMpower130. Progression-free survival (PFS) and safety analysis from a randomised phase 3 study of carboplatin + nab-paclitaxel (CnP) with o without atezolizumab (atezo) as first-line (1L) therapy in advanced non-squamous NSCLC 20% Pemetrexed switch maintenance
3 LBA53. IMpower130. Progression-free survival (PFS) and safety analysis from a randomised phase 3 study of carboplatin + nab-paclitaxel (CnP) with o without atezolizumab (atezo) as first-line (1L) therapy in advanced non-squamous NSCLC
4 LBA53. IMpower130. Progression-free survival (PFS) and safety analysis from a randomised phase 3 study of carboplatin + nab-paclitaxel (CnP) with o without atezolizumab (atezo) as first-line (1L) therapy in advanced non-squamous NSCLC Cross over to immunotherapy 135 (59,2%)
5 LBA53. IMpower130. Progression-free survival (PFS) and safety analysis from a randomised phase 3 study of carboplatin + nab-paclitaxel (CnP) with o without atezolizumab (atezo) as first-line (1L) therapy in advanced non-squamous NSCLC
6 LBA53. IMpower130. Progression-free survival (PFS) and safety analysis from a randomised phase 3 study of carboplatin + nab-paclitaxel (CnP) with o without atezolizumab (atezo) as first-line (1L) therapy in advanced non-squamous NSCLC Benefit in this subgroup not confirmed
7 LBA53. IMpower130. Progression-free survival (PFS) and safety analysis from a randomised phase 3 study of carboplatin + nab-paclitaxel (CnP) with o without atezolizumab (atezo) as first-line (1L) therapy in advanced non-squamous NSCLC OS and PFS benefits were observed across all PD-L1 subgroups
8 LBA53. IMpower130. Progression-free survival (PFS) and safety analysis from a randomised phase 3 study of carboplatin + nab-paclitaxel (CnP) with o without atezolizumab (atezo) as first-line (1L) therapy in advanced non-squamous NSCLC Atezo + CnP had a safety profile consistent with AEs associated with single-agent therapy No new safety signals were identified
9 LBA53. IMpower130. Progression-free survival (PFS) and safety analysis from a randomised phase 3 study of carboplatin + nab-paclitaxel (CnP) with o without atezolizumab (atezo) as first-line (1L) therapy in advanced non-squamous NSCLC CONCLUSIONS
10 LBA54. IMpower132. Efficacy of atezolizumab (atezo) + carboplatin (carbo)/cisplatin (cis) + pemetrexed (pem) as 1L treatment in key subgroups with stage IV nonsquamous non-small cell lung cancer (NSCLC)
11 LBA54. IMpower132. Efficacy of atezolizumab (atezo) + carboplatin (carbo)/cisplatin (cis) + pemetrexed (pem) as 1L treatment in key subgroups with stage IV nonsquamous non-small cell lung cancer (NSCLC) Clear improvement of PFS and OS adding Atezolizumab
12 LBA54. IMpower132. Efficacy of atezolizumab (atezo) + carboplatin (carbo)/cisplatin (cis) + pemetrexed (pem) as 1L treatment in key subgroups with stage IV nonsquamous non-small cell lung cancer (NSCLC)
13 LBA54. IMpower132. Efficacy of atezolizumab (atezo) + carboplatin (carbo)/cisplatin (cis) + pemetrexed (pem) as 1L treatment in key subgroups with stage IV nonsquamous non-small cell lung cancer (NSCLC)
14 LBA54. IMpower132. Efficacy of atezolizumab (atezo) + carboplatin (carbo)/cisplatin (cis) + pemetrexed (pem) as 1L treatment in key subgroups with stage IV nonsquamous non-small cell lung cancer (NSCLC)
15 LBA54. IMpower132. Efficacy of atezolizumab (atezo) + carboplatin (carbo)/cisplatin (cis) + pemetrexed (pem) as 1L treatment in key subgroups with stage IV nonsquamous non-small cell lung cancer (NSCLC) CONCLUSIONS
16 LBA55. Primary efficacy results from B-F1RST, a prospective phase II trial evaluating blood-based tumour mutational burden (btmb) as a predictive biomarker for atezolizumab (atezo) in 1L non-small cell lung cancer (NSCLC)
17 LBA55. Primary efficacy results from B-F1RST, a prospective phase II trial evaluating blood-based tumour mutational burden (btmb) as a predictive biomarker for atezolizumab (atezo) in 1L non-small cell lung cancer (NSCLC)
18 LBA55. Primary efficacy results from B-F1RST, a prospective phase II trial evaluating blood-based tumour mutational burden (btmb) as a predictive biomarker for atezolizumab (atezo) in 1L non-small cell lung cancer (NSCLC) PFS and OS improvement were seen with increasing btmb cutoffs
19 LBA55. Primary efficacy results from B-F1RST, a prospective phase II trial evaluating blood-based tumour mutational burden (btmb) as a predictive biomarker for atezolizumab (atezo) in 1L non-small cell lung cancer (NSCLC) CONCLUSIONS B-F1RST is the first prospective evaluation of btmb as a predictive biomarker for patients with NSCLC receiving 1L atezolizumab monotherapy These primary data suggest that a btmb cutoff score of 16 showed a numerical improvement in clinical outcomes in patients with NSCLC treated with atezolizumab monotherapy: Median PFS in btmb high vs low subgroups, 4.6 vs 3.7 months (HR, 0.66 [90% CI: 0.42, 1.02]; P = 0.12) Confirmed ORR of 28.6% and 4.4% (P = ) was observed in the btmb high ( 16) and low (< 16) subgroups, respectively Median OS in the btmb high vs low subgroups was NE vs 13.1 months (HR, 0.77 [90% CI, ]; P = 0.48) and will continue to be followed Atezolizumab was well tolerated, and no new safety signals were observed btmb is being validated in a prospective, randomised Phase III study
20 ARCTIC: Durvalumab + Tremelimumab and Durvalumab monotherapy vs SoC in 3L advanced NSCLC treatment
21 ARCTIC: Durvalumab + Tremelimumab and Durvalumab monotherapy vs SoC in 3L advanced NSCLC treatment PD-L1 TC 25%: Durvalumab monotherapy resulted in a clinically meaningful improvement in OS vs SoC with 49.3% vs 31.3% of patients alive at 1 year PD-L1 TC <25%: Durvalumab + Tremelimumab demonstrated a non-significant numerical improvement in OS vs SoC with 49.5% vs 38.8% of patients alive at 1 year
22 ARCTIC: Durvalumab + Tremelimumab and Durvalumab monotherapy vs SoC in 3L advanced NSCLC treatment CONCLUSIONS ARCTIC demonstrated activity with both Durvalumab and Durvalumab + Tremelimumab in a heavily pretreated patient population with advanced/metastatic NSCLC Durvalumab and Tremelimumab had an acceptable toxicity profile Incorporation of TMB along with PD-L1 in the assessment of benefit may be useful Await Phase 3 MYSTIC OS data
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