Date Printed: 04/15/2008 Date Updated: 01/31/2006 Version 1.6 P-DIMETHYLAMINOAZOBENZENE CRYSTALLINE

Transcription

1 SIGMA-ALDRICH MATERIAL SAFETY DATA SHEET Date Printed: 04/15/2008 Date Updated: 01/31/2006 Version 1.6 Section 1 - Product and Company Information Product Name Product Number Brand P-DIMETHYLAMINOAZOBENZENE CRYSTALLINE D6760 SIGMA Company Address Technical Phone: Fax: Emergency Phone: Sigma-Aldrich Canada, Ltd 2149 Winston Park Drive Oakville ON L6H 6J8 CA Section 2 - Composition/Information on Ingredient Substance Name CAS # SARA DIMETHYLAMINOAZOBENZENE Yes Formula Synonyms C14H15N3 Atul Fast Yellow R * Azobenzene, p-dimethylamino- * Benzenamine, N,N-dimethyl-4-(phenylazo)- (9CI) * Benzeneazodimethylaniline * Brilliant Fast Oil Yellow * Brilliant Fast Spirit Yellow * Brilliant Fast Yellow * Brilliant Oil Yellow * Butter Yellow * Cerasine Yellow GG * C.I * C.I. Solvent Yellow 2 * DAB (carcinogen) * p-dimethylaminoazobenzen (Czech) * N,N-Dimethyl-p-aminoazobenzene * N,N-Dimethyl-4-aminoazobenzene * p-dimethylaminoazobenzene * 4-(N,N-Dimethylamino)azobenzene * 4-Dimethylaminoazobenzene (OSHA) * p-dimethylamino-azobenzol (German) * 4-Dimethylaminoazobenzol * 4-Dimethylaminophenylazobenzene * N,N-Dimethyl-p-azoaniline * N,N-Dimethyl-p-phenylazoaniline * N,N-Dimethyl-4-(phenylazo)benzamine * N,N-Dimethyl-4-(phenylazo)benzenamine * Dimethyl Yellow * Dimethyl Yellow Analar * Dimethyl Yellow N,N-dimethylaniline * DMAB * Enial Yellow 2G * Fast Oil Yellow B * Fast Yellow * Fat Yellow * Fat Yellow A * Fat Yellow AD OO * Fat Yellow ES * Fat Yellow ES Extra * Fat Yellow Extra Conc. * Fat Yellow R * Fat Yellow R (8186) * Grasal Brilliant Yellow * Iketon Yellow Extra * Jaune de beurre (French) * Methyl Yellow * Oil Yellow II * Oil Yellow 20 * Oil Yellow 2625 * Oil Yellow 7463 * Oil Yellow BB * Oil Yellow D * Oil Yellow DN * Oil Yellow FF * Oil Yellow FN * Oil Yellow G * Oil Yellow 2G * Oil Yellow G-2 * Oil Yellow GG * Oil Yellow GR * Oil Yellow N * Oil Yellow PEL * Oil Yellow S * Oleal Yellow 2G * Organol Yellow

2 RTECS Number: ADM * Orient Oil Yellow GG * P.D.A.B. * Petrol Yell BX Section 3 - Hazards Identification EMERGENCY OVERVIEW Toxic. Toxic if swallowed. Teratogen. Possible mutagen. Target organ(s): Liver. Bladder. Confirmed Carcinogen (US). Calif. Prop. 65 carcinogen. HMIS RATING HEALTH: 2* FLAMMABILITY: 0 REACTIVITY: 0 NFPA RATING HEALTH: 2 FLAMMABILITY: 0 REACTIVITY: 0 *additional chronic hazards present. For additional information on toxicity, please refer to Section 11. Section 4 - First Aid Measures ORAL EXPOSURE If swallowed, wash out mouth with water provided person is conscious. Call a physician. INHALATION EXPOSURE If inhaled, remove to fresh air. If breathing becomes difficult, call a physician. DERMAL EXPOSURE In case of contact, immediately wash skin with soap and copious amounts of water. EYE EXPOSURE In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician. Section 5 - Fire Fighting Measures FLASH POINT AUTOIGNITION TEMP FLAMMABILITY EXTINGUISHING MEDIA Suitable: Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. FIREFIGHTING Protective Equipment: Wear self-contained breathing apparatus SIGMA - D Page 2

3 and protective clothing to prevent contact with skin and eyes. Specific Hazard(s): Emits toxic fumes under fire conditions. Section 6 - Accidental Release Measures PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL Evacuate area. PROCEDURE(S) OF PERSONAL PRECAUTION(S) Wear self-contained breathing apparatus, rubber boots, and heavy rubber gloves. Wear disposable coveralls and discard them after use. METHODS FOR CLEANING UP Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete. Section 7 - Handling and Storage HANDLING User Exposure: Do not breathe dust. Do not get in eyes, on skin, on clothing. Avoid prolonged or repeated exposure. STORAGE Suitable: Keep tightly closed. Section 8 - Exposure Controls / PPE ENGINEERING CONTROLS Use only in a chemical fume hood. Safety shower and eye bath. PERSONAL PROTECTIVE EQUIPMENT Respiratory: Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Where risk assessment shows air-purifying respirators are appropriate use a full-face particle respirator type N100 (US) or type P3 (EN 143) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Hand: Compatible chemical-resistant gloves. Eye: Chemical safety goggles. GENERAL HYGIENE MEASURES Wash contaminated clothing before reuse. Wash thoroughly after handling. SPECIAL PRECAUTIONS For protection and handling requirements consult CFR title 29 part EXPOSURE LIMITS, RTECS Country Source Type Value USA NIOSH USE 29 CFR Section 9 - Physical/Chemical Properties Appearance Physical State: Solid Property Value At Temperature or Pressure Molecular Weight AMU SIGMA - D Page 3

4 ph BP/BP Range MP/MP Range 115 C Freezing Point Vapor Pressure Vapor Density Saturated Vapor Conc. SG/Density Bulk Density Odor Threshold Volatile% VOC Content Water Content Solvent Content Evaporation Rate Viscosity Surface Tension Partition Coefficient Decomposition Temp. Flash Point Explosion Limits Flammability Autoignition Temp Refractive Index Optical Rotation Miscellaneous Data Solubility = not available Section 10 - Stability and Reactivity STABILITY Stable: Stable. Materials to Avoid: Acids, Acid anhydrides, Oxidizing agents. HAZARDOUS DECOMPOSITION PRODUCTS Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide, Nitrogen oxides. HAZARDOUS POLYMERIZATION Hazardous Polymerization: Will not occur Section 11 - Toxicological Information cancer suspect agent ROUTE OF EXPOSURE Skin Contact: May cause skin irritation. Skin Absorption: May be harmful if absorbed through the skin. Eye Contact: May cause eye irritation. Inhalation: Material may be irritating to mucous membranes and upper respiratory tract. May be harmful if inhaled. Ingestion: Toxic if swallowed. TARGET ORGAN(S) OR SYSTEM(S) Liver. Bladder. Blood. Kidneys. SIGNS AND SYMPTOMS OF EXPOSURE Absorption into the body leads to the formation of methemoglobin which in sufficient concentration causes cyanosis. Onset may be delayed 2 to 4 hours or longer. SIGMA - D Page 4

5 TOXICITY DATA Oral Rat 200 mg/kg LD50 Intraperitoneal Rat 230 MG/KG LD50 Remarks: Lungs, Thorax, or Respiration:Cyanosis. Lungs, Thorax, or Respiration:Dyspnea. Oral Mouse 300 mg/kg LD50 Intraperitoneal Mouse 230 MG/KG LD50 Remarks: Lungs, Thorax, or Respiration:Cyanosis. Lungs, Thorax, or Respiration:Dyspnea. CHRONIC EXPOSURE - CARCINOGEN Result: This is or contains a component that has been reported to be carcinogenic based on its IARC, OSHA, ACGIH, NTP, or EPA classification. Dose: 5426 MG/KG Exposure Time: 17W Result: Liver:Tumors. Tumorigenic:Carcinogenic by RTECS criteria. Route of Application: Skin Dose: 1440 MG/KG Exposure Time: 90W Frequency: I Result: Skin and Appendages: Other: Tumors. Tumorigenic:Neoplastic by RTECS criteria. Route of Application: Intraperitoneal Dose: 3830 UG/KG Result: Liver:Tumors. Tumorigenic:Neoplastic by RTECS criteria. Route of Application: Subcutaneous Result: Lungs, Thorax, or Respiration:Tumors. Tumorigenic Effects: Uterine tumors. Tumorigenic:Carcinogenic by RTECS criteria. Route of Application: Multiple Dose: 400 MG/KG Frequency: I SIGMA - D Page 5

6 Result: Tumorigenic:Tumors at site or application. Liver:Tumors. Tumorigenic:Equivocal tumorigenic agent by RTECS criteria. Species: Dog Dose: 9600 MG/KG Exposure Time: 69W Result: Kidney, Ureter, Bladder:Tumors. Tumorigenic:Equivocal tumorigenic agent by RTECS criteria. Species: Hamster Dose: 9600 MG/KG Exposure Time: 42W Frequency: I Result: Liver:Change in gall bladder structure or function. Blood:Other hemolysis with or withot anemia. Tumorigenic:Equivocal tumorigenic agent by RTECS criteria. Dose: 2600 MG/KG Exposure Time: 13W Result: Liver:Tumors. Tumorigenic:Neoplastic by RTECS criteria. Dose: 13 GM/KG Exposure Time: 53W Result: Tumorigenic:Neoplastic by RTECS criteria. Liver:Tumors. Dose: 1920 MG/KG Exposure Time: 14W Result: Liver:Tumors. Tumorigenic:Equivocal tumorigenic agent by RTECS criteria. Dose: 1800 MG/KG Exposure Time: 14W Result: Liver:Tumors. Tumorigenic:Equivocal tumorigenic agent by RTECS criteria. Dose: 2331 MG/KG Exposure Time: 7W Frequency: I Result: Liver:Tumors. Tumorigenic:Equivocal tumorigenic agent by RTECS criteria. Dose: MG/KG Exposure Time: 17W SIGMA - D Page 6

7 Result: Liver:Tumors. Tumorigenic:Neoplastic by RTECS criteria. Dose: 8316 MG/KG Exposure Time: 33W Result: Liver:Tumors. Tumorigenic:Neoplastic by RTECS criteria. Dose: 3990 MG/KG Exposure Time: 19W Result: Lungs, Thorax, or Respiration:Consolidation. Liver:Tumors. Tumorigenic:Neoplastic by RTECS criteria. Route of Application: Intraperitoneal Dose: 11 MG/KG Result: Liver:Tumors. Tumorigenic:Neoplastic by RTECS criteria. Dose: 800 MG/KG Exposure Time: 64D Result: Tumorigenic:Equivocal tumorigenic agent by RTECS criteria. Liver:Tumors. OSHA CARCINOGEN LIST cancer suspect agent IARC CARCINOGEN LIST Rating: Group 2B NTP CARCINOGEN LIST Rating: Anticipated to be a carcinogen. CHRONIC EXPOSURE - TERATOGEN Result: May cause congenital malformation in the fetus. Dose: 200 MG/KG Route of Application: Subcutaneous Exposure Time: (10D PREG) Result: Specific Developmental Abnormalities: Musculoskeletal system. CHRONIC EXPOSURE - MUTAGEN Result: Laboratory experiments have shown mutagenic effects. Species: Human Dose: 10 NMOL/L Cell Type: HeLa cell Species: Human SIGMA - D Page 7

8 Dose: 4 MG/L Cell Type: fibroblast Species: Human Dose: 100 UMOL/L Cell Type: HeLa cell Mutation test: DNA inhibition Dose: 1 UMOL/L Cell Type: liver Dose: 12 MG/L Cell Type: Embryo Route: Oral Dose: 300 MG/KG Mutation test: DNA Dose: 150 MG/KG Mutation test: DNA Dose: 1 UMOL/L Cell Type: liver Dose: 600 MG/KG Cell Type: S. typhimurium Mutation test: Body fluid assay Route: Oral Dose: 756 MG/KG Exposure Time: 3W Mutation test: Cytogenetic analysis Dose: 6400 UG/KG Mutation test: Micronucleus test Dose: 6250 UG/L (+S9) Cell Type: lymphocyte Mutation test: Mutation in microorganisms Dose: 89 UMOL/L Cell Type: Embryo SIGMA - D Page 8

9 Dose: 120 MG/KG Mutation test: DNA Route: Skin Dose: 192 UMOL/KG Mutation test: DNA Route: Oral Dose: 500 MG/KG Mutation test: DNA damage Dose: 1 UMOL/L Cell Type: liver Dose: 20 GM/KG Mutation test: DNA inhibition Route: Oral Dose: 100 MG/KG Mutation test: DNA inhibition Dose: 29 MG/KG Mutation test: Sister chromatid exchange Dose: 89 UMOL/L Cell Type: lymphocyte Mutation test: Mutation in mammalian somatic cells. Dose: 255 MG/KG Exposure Time: 3H Cell Type: S. typhimurium Mutation test: Host-mediated assay Dose: 3 GM/KG Exposure Time: 5D Mutation test: sperm Species: Hamster Dose: 500 MG/KG Species: Hamster Dose: 50 UG/L Cell Type: Embryo Species: Hamster Dose: 25 MG/L SIGMA - D Page 9

10 Cell Type: kidney Species: Hamster Dose: 1 UMOL/L Cell Type: liver Species: Non-mammalian Dose: 250 UG/L Cell Type: Other cell types CHRONIC EXPOSURE - REPRODUCTIVE HAZARD Dose: 3 GM/KG Route of Application: Intraperitoneal Exposure Time: (5D MALE) Result: Paternal Effects: Spermatogenesis (including genetic material, sperm morphology,motility, and count). Section 12 - Ecological Information No data available. Section 13 - Disposal Considerations APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION Contact a licensed professional waste disposal service to dispose of this material. Observe all federal, state, and local environmental regulations. (DN)Requires special label: "Contains a substance which is regulated by Dannish work environmental law due to the risk of carcinogenic properties." Section 14 - Transport Information DOT Proper Shipping Name: Toxic solids, organic, n.o.s. UN#: 2811 Class: 6.1 Packing Group: Packing Group III Hazard Label: Toxic substances. PIH: Not PIH IATA Proper Shipping Name: Toxic solid, organic, n.o.s. IATA UN Number: 2811 Hazard Class: 6.1 Packing Group: III Section 15 - Regulatory Information EU ADDITIONAL CLASSIFICATION Symbol of Danger: T Indication of Danger: Toxic. R: Risk Statements: Toxic if swallowed. Limited evidence of a carcinogenic effect. S: 36/37-45 Safety Statements: Wear suitable protective clothing and gloves. In case of accident or if you feel unwell, seek medical advice SIGMA - D Page 10

11 immediately (show the label where possible). US CLASSIFICATION AND LABEL TEXT Indication of Danger: Toxic. Risk Statements: Toxic if swallowed. Safety Statements: Avoid exposure - obtain special instructions before use. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). US Statements: Teratogen. Possible mutagen. Target organ(s): Liver. Bladder. Confirmed Carcinogen (US). Calif. Prop. 65 carcinogen. UNITED STATES REGULATORY INFORMATION SARA LISTED: Yes DEMINIMIS: 0.1 % NOTES: This product is subject to SARA section 313 reporting requirements. TSCA INVENTORY ITEM: Yes UNITED STATES - STATE REGULATORY INFORMATION OSHA Remarks: OSHA-regulated carcinogen. See CFR title 29 part CALIFORNIA PROP - 65 California Prop - 65: This product is or contains chemical(s) known to the state of California to cause cancer. CANADA REGULATORY INFORMATION WHMIS Classification: This product has been classified in accordance with the hazard criteria of the CPR, and the MSDS contains all the information required by the CPR. DSL: Yes NDSL: No Section 16 - Other Information DISCLAIMER For R&D use only. Not for drug, household or other uses. WARRANTY The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Inc., shall not be held liable for any damage resulting from handling or from contact with the above product. See reverse side of invoice or packing slip for additional terms and conditions of sale. Copyright 2008 Sigma-Aldrich Co. License granted to make unlimited paper copies for internal use only. SIGMA - D Page 11