ORAL MAXILLOFACIAL PATHOLOGY REPORT RL;MMR; 1 of 1. A Copy was sent to: DR. JANE O. DOE 456 SAMPLE BLVD DIAGNOSIS

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1 Batch#: ccession: Obtained: 04/07/20XX Received: 04/07/20XX MIN ST FLUSHING, NY (718) DOB: 01/02/19XX 8:34 pm PTIENT: JCK JONES ORL MXILLOFCIL PTHOLOGY REPORT RL;MMR; 1 of 1 Specimen Preliminary Date Final Report Date cct#: 1018 ge: 58 Sex: Male Submitted: 1 vial- Copy was sent to: DR. JNE O. DOE 456 SMPLE BLVD DIGNOSIS BC SURGERY CENTER PHYSICIN: JOHN O. SMITH 1234 FIRST VE, Suite: 8 cct # LT LTERL TONGUE POSTERIOR SPECT DIGNOSIS: SQUMOUS CELL CRCINOM, POORLY DIFFERENTITED Notes: Carcinoma extends to the lateral edges of the biopsy. Deep margin appears to be free of carcinoma. Dr. Lee reviewed the case and concurred with the diagnosis. Microscopic Description: There are irregular masses of atypical keratinocytes in the submucosa and muscle. Surface ulcer is present. Preliminary Reasons: In House Review Grossing Information: Received in 10% Formalin is a specimen measuring 10x07x01 mm, color is white tan, shape is Irregular and submitted in 1 block, 1 piece. Clinical Impression: NON HELING ULCER. This SR has been prepared and validated according to manufacturer recommendations and its performance characteristics have been evaluated as to how they contribute to the global clinical applications within cupath s diagnostic services. With the exception of HercepTest, this reagent has not been cleared by The U.S. Food Drug dministration. The FD has determined that such clearance or approval is not necessary. This test is used for clinical applications only. This laboratory is certified under CLI-88 amendments to perform high complexity clinical laboratory testing. Color Key: Cancer Precancer/Dysplasia Benign Infectious Inflammatory Suspicious Other typical Photomicrograph of John Brown Olga Falkowski, M.D., Medical Director : (LT LTERL TONGUE POSTERIOR SPECT) SQUMOUS CELL CRCINOM, POORLY DIFFERENTITED JCK JONES JCK JONES Submitted: 1 vial- : (LT LTERL TONGUE POSTERIOR SPECT) SQUMOUS CELL CRCINOM, POORLY DIFFERENTITED JCK JONES Submitted: 1 vial- JCK JONES 04/07/20XX Page 1 of 1

2 Patient: JOHN JONES Date Obtained: 4/7/20XX Date of Birth: 01/02/19XX Doctor: Dr. JOHN O. SMITH For Site(s): (212) PTIENT FCT SHEET TM SQUMOUS CELL CRCINOM Definition: The second most common type of skin cancer, originating in the cells of the skin known as keratinocytes. It usually presents as a red scaly patch, nodule, or ulceration and is most commonly found on the rim of the ear, the back of the hand, the forearms, and around the mouth. RISK FCTORS The sun is the most significant factor in the development of squamous cell carcinoma, but x-ray exposure, chronic skin disease, burns, genetic disease, and carcinogens such as tar, pitch, and soot may increase risk. When detected early, cure rates exceed 95%. METHOD OF DIGNOSIS Many clinicians can diagnose squamous cell carcinoma by careful observation. However, the removal of a small sample from the affected area for analysis at a reputable pathology laboratory was required for absolute confirmation of the diagnosis, as other conditions can mimic it clinically. Your sample was studied by a specialized pathologist at cupath Laboratories, Inc. before being conclusively diagnosed as Squamous Cell Carcinoma. COMMON TRETMENTS Squamous cell carcinoma may be treated by a variety of minor surgical procedures. Your doctor will decide which type of therapy is best for you. PREVENTTIVE MESURES - Examine all areas of your skin, looking for growths or changes in moles, and seek prompt medical assistance in the case of any abnormality. - void excessive sun exposure, especially burns. - Use sunscreens and protective clothing. - See your doctor annually for a complete exam, alerting him/her of any irregularities you may have noticed. COMMENTS Provided as a service by cupath Laboratories in cooperation with your doctor. cupath Laboratories, Inc. "For the absolute highest standard in pathology services."

3 Batch#: ccession: Obtained: 04/07/20XX Received: 04/07/20XX MIN ST FLUSHING, NY (718) DOB: 01/02/19XX 8:34 pm PTIENT: JCK JONES ORL MXILLOFCIL PTHOLOGY REPORT RL;MMR; 1 of 1 Specimen Preliminary Date Final Report Date cct#: 1018 ge: 58 Sex: Male Submitted: 1 vial- Duplicate Report For: DR. JNE O. DOE 456 SMPLE BLVD DIGNOSIS BC SURGERY CENTER PHYSICIN: JOHN O. SMITH 1234 FIRST VE, Suite: 8 cct # LT LTERL TONGUE POSTERIOR SPECT DIGNOSIS: SQUMOUS CELL CRCINOM, POORLY DIFFERENTITED Notes: Carcinoma extends to the lateral edges of the biopsy. Deep margin appears to be free of carcinoma. Dr. Lee reviewed the case and concurred with the diagnosis. Microscopic Description: There are irregular masses of atypical keratinocytes in the submucosa and muscle. Surface ulcer is present. Preliminary Reasons: In House Review Grossing Information: Received in 10% Formalin is a specimen measuring 10x07x01 mm, color is white tan, shape is Irregular and submitted in 1 block, 1 piece. Clinical Impression: NON HELING ULCER. This SR has been prepared and validated according to manufacturer recommendations and its performance characteristics have been evaluated as to how they contribute to the global clinical applications within cupath s diagnostic services. With the exception of HercepTest, this reagent has not been cleared by The U.S. Food Drug dministration. The FD has determined that such clearance or approval is not necessary. This test is used for clinical applications only. This laboratory is certified under CLI-88 amendments to perform high complexity clinical laboratory testing. Color Key: Cancer Precancer/Dysplasia Benign Infectious Inflammatory Suspicious Other typical Photomicrograph of John Brown Olga Falkowski, M.D., Medical Director : (LT LTERL TONGUE POSTERIOR SPECT) SQUMOUS CELL CRCINOM, POORLY DIFFERENTITED JCK JONES JCK JONES Submitted: 1 vial- : (LT LTERL TONGUE POSTERIOR SPECT) SQUMOUS CELL CRCINOM, POORLY DIFFERENTITED JCK JONES Submitted: 1 vial- JCK JONES 04/07/20XX DR. JNE O. DOE 456 SMPLE BLVD Rte 6 Page 1 of 1

4 BC SURGERY CENTER JOHN O. SMITH, M.D First venue New York, NY pril 8, 20XX Dr. Jane O. Doe 456 Sample Blvd Re: Jack S. Jones Dear Dr. O. Doe: I had the pleasure of treating your patient Jack S Jones, a 58 year old male, on pril 7, 20XX. The specimen was sent for pathologic interpretation to cupath Laboratories, Inc. The histopathologic interpretation of the specimen from the () LT LTERL TONGUE POSTERIOR SPECT revealed squamous cell carcinoma, poorly differentiated. Carcinoma extends to the lateral edges of the biopsy. Deep margin appears to be free of carcinoma. Dr. Lee reviewed the case and concurred with the diagnosis. I would like to personally thank you for your kind referral. If you have any additional questions, please do not hesitate to contact me at Sincerely, JOHN O. SMITH, M.D.

5 Batch#: ccession: Obtained: 05/01/20XX Received: 05/01/20XX 12:23 pm PTIENT: 1234 NYWHERE NYWHERE, NY (516) DOB: 06/05/19XX Specimen Final Report Date cct#: 1012 ge: 80 Sex: Female Submitted: 1 vial- CYTOPTHOLOGY REPORT *RL;MMR; 1 of 1 05/02/XX Chart//C#20XXX5 Copy was sent to: DR. JNE GE. DOE 456 SMPLE BLVD. NEW YORK, NY DIGNOSIS BC SURGERY CENTER PHYSICIN: JOHN Y SMITH 1234 FIRST VE, Suite: 8 cct # SPUTUM DIGNOSIS: FRGMENTS OF BENIGN PPERING SUPERFICIL SQUMOUS EPITHELIUM; CYTOSPIN REVELS BENIGN SQUMOUS EPITHELIL CELLS ONLY Notes: The case was discussed with Dr. Lee on 5/2/20XX. Microscopic Description: Sections reveal superficial fragments of squamous epithelium. Grossing Information: Received in 10% Formalin is a specimen measuring 24x03x02 mm, color is tan, shape is Irregular and submitted in 3 blocks, multiple pieces. Grossing Comments: Largest piece measured - see above Photomicrograph of Diagram not indicated John Brown Olga Falkowski, M.D., Medical Director : (SPUTUM) FRGMENTS OF BENIGN PPERING SUPERFICIL SQU...See Report (516) DOB: 06/05/19XX Submitted: 1 vial- : (SPUTUM) FRGMENTS OF BENIGN PPERING SUPERFICIL SQU...See Report (516) DOB: 06/05/19XX Submitted: 1 vial- 05/01/20XX Page 1 of 1

6 MOLECULR ISH REPORT RL;MMR; Page 1 of 1 CCESSION: Obtained: 01/23/20XX Received: PRCTICE: PHYSICIN: 01/28/20XX 12:00 am BC SURGERY CENTER JOHN D. SMITH 1234 FIRST VE Suite: 8 ccount # Rte 6 Indications: Posterior Tongue Source of Tissue: Tongue Date Reported: 01/31/20XX Copy was sent to: DR. JNE DOE 456 SMPLE BLVD NEW YORK, NY 2:51PM PTIENT: JCK S. JONES MIN ST FLUSHING, NY Phone #: (718) Chart//C#2XXXX6 ge: 63 DOB: 01/02/19XX Sex: Male cct: 1018 TEST RESULT ISH/Probe Marker For Results HPV WS Wide Screen HPV Positive HPV 6/11 HPV Types 6/11 Negative HPV 16/18 HPV Types 16/18 Negative HPV 31/33 HPV Types 31/33 Negative INTERPRETTION: This specimen is POSITIVE for one or more of the following strains of HPV: 6/11/16/18/31/33/35/45/51/52. The following subtypes were: NEGTIVE for Low-Risk HPV strains 6/11 NEGTIVE for High-Risk HPV strains 16/18 NEGTIVE for High-Risk HPV strains 31/33 The HPV Wide Spectrum is used to detect HPV DN by In Situ Hybridization (ISH) in biopsies; it does not discriminate between the HPV subtype. The HPV Wide Spectrum detects subtypes 6, 11, 16, 18, 30, 31, 33, 35, 45, 51, and 52. The absence of hybridization with HPV subtypes 6, 11, 16, 18, 31, and 33 may indicate other subtypes that were not analyzed in this study. This analysis is an adjunct to the evaluation of the referring physician and does not represent a final diagnosis. Photomicrographs: HPV ISH WS Electronically signed by: This test was developed and its performance characteristics determined by cupath Laboratories, Inc. It has not been cleared or approved by the U.S. Food and Drug dministration. The FD has determined that such clearance or approval is not necessary. This test is used for clinical purposes. Pursuant to the requirements of CLI 88, this laboratory has established the test s accuracy and precision. This test has been approved by New York State as a laboratory specific assay. This test cannot be used as sole evidence for or against cancer and has to be interpreted in the context of all available clinical and pathological information.

7 Patient: JCK S. JONES Date Obtained: 01/23/20XX Date of Birth: 01/02/19XX Doctor: Dr. JOHN D. SMITH For Site(s): (212) PTIENT FCT SHEET TM CONDYLOM CUMINT Definition: Commonly known as genital warts, Condyloma cuminata is a sexually transmitted disease caused by the Human Papilloma Virus (HPV). It is characterized by wart-like growths on the penis, vagina, vulva, and/or rectum. In rarer cases HPV may cause warts on the throat, tongue, and mouth. FCTS/RISK FCTORS Over 50 different types of HPV have been identified. Some lead to rough raised warts, while others to soft flat ones. Several types have been associated with abnormal pap smears in women, which may indicate an increased risk for cervical cancer. Unsafe sexual practices such as multiple/unknown sexual partners and lack of condom use increase the risk of contracting HPV. SYMPTOMS lthough many patients display no symptoms at all, infection by HPV may cause: - warts/lesions in the genital and/or anal areas - cauliflower-like growths around the genitals and/or anus - dampness - itching METHOD OF DIGNOSIS Many clinicians can diagnose Condyloma by careful observation. However, the removal of a small sample from the affected area for analysis at a reputable pathology laboratory is required for absolute confirmation of the diagnosis, as other conditions can mimic it clinically. Your sample is studied by a specialized pathologist at cupath Laboratories, Inc. before being conclusively diagnosed as Condyloma cuminata. METHODS OF TRETMENT Methods of treatment include both topical medications and minor surgical procedures. Your doctor will decide which type of therapy is best suited for you. COMMENTS Provided as a service by cupath Laboratories in cooperation with your doctor. cupath Laboratories, Inc. "For the absolute highest standard in pathology services."

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