Plasmacytoid urothelial carcinoma: a case of histological variant of urinary bladder cancer with aggressive behavior

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1 Article / Clinical Case Reports Artigo / Relato de Caso Clínico Plasmacytoid urothelial carcinoma: a case of histological variant of urinary bladder cancer with aggressive behavior Leonardo Gomes da Fonseca a, Ciro Eduardo Souza a, Romulo Loss Mattedi b, Daniel Motta Girardi a, Álvaro Sadek Sarkis c, Paulo Marcelo Gem Hoff a Fonseca LG, Souza CE, Mattedi RL, Girardi DM, Sarkis AS, Hoff PMG. Plasmacytoid urothelial carcinoma: a case of histological variant of urinary bladder cancer with aggressive behavior. Autopsy Case Rep [Internet]. 2014;4(4): dx.doi.org/ /acr ABSTRACT Plasmocytoid variant urothelial carcinoma (PVUC) of the urinary bladder is a rare histological variant of transitional cell carcinoma. Data regarding PVUC shows that this neoplasia presents a distinctive clinical outcome represented by aggressive behavior and poor survival rate. The authors report a case of a 57-year-old male patient with a 3-month history of hematuria and pelvic pain. Radical cystectomy with lymphadenectomy was performed and pathological examination showed a pt3pn0 PVUC of the bladder. The patient remained free of recurrence for 8 months, but the disease recurred involving the abdominal wall and subcutaneous tissue. Chemotherapy provided a positive clinical response and relief of symptoms. The authors call attention to the aggressiveness of this rare variant of bladder cancer and recommend radical surgery and multidisciplinary management of this neoplasm. Keywords Carcinoma; Urothelium; Urinary Bladder Neoplasms; Cystectomy. CASE REPORT A 57-year-old man sought the Urology Service complaining of pelvic pain and hematuria for three months. His past medical history included heavy smoking. No familial history of cancer was present. The first diagnostic approach involved a cystoscopy, which revealed thickened urinary bladder mucosa. Therefore he was submitted to transurethral resection, which showed a muscle-invasive urothelial carcinoma on histological examination. Initial pelvic, abdominal and thoracic computed tomography (CT) showed bladder wall thickening (Figure 1) without regional or distant lymphadenopathy neither distant metastasis. A radical cystectomy with lymphadenectomy was performed. Pathological examination showed plasmocytoid urothelial carcinoma invading perivesical adipose tissue and anterior bladder wall. (Figure 2) The urethral margins were tumor free but perineural invasion was present. No tumoral involvement was observed in 9 dissected lymph nodes. The immunohistochemistry study revealed positivity to cytokeratin CK7, CK20, 34bE12 and CD138. Napsin A, CDX-2, p63 and E-cadherin were negative. Pathological staging was pt3pn0. (Figure 3) a Department of Clinical Oncology - Instituto do Câncer do Estado de São Paulo - São Paulo/SP, Brazil. b Department of Pathology - Instituto do Câncer do Estado de São Paulo - São Paulo/SP, Brazil. c Department of Urology - Instituto do Câncer do Estado de São Paulo - São Paulo/SP, Brazil. Autopsy and Case Reports. ISSN Copyright This is an Open Access article distributed of terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted noncommercial use, distribution, and reproduction in any medium provided article is properly cited.

Plasmacytoid urothelial carcinoma: a case of histological variant of urinary bladder cancer with aggressive behavior After 8 months, the patient presented progressive swelling and pain in the

A biopsy of the subcutaneous adipose tissue confirmed poorly cohesive and plasmocytoid features of the carcinoma compatible with high-grade urothelial carcinoma.

2 Plasmacytoid urothelial carcinoma: a case of histological variant of urinary bladder cancer with aggressive behavior After 8 months, the patient presented progressive swelling and pain in the suprapubic region and scrotum. CT scan showed a densification of adipose and muscle layers of the anterior abdominal wall extending to the scrotum. (Figure 4). A biopsy of the subcutaneous adipose tissue confirmed poorly cohesive and plasmocytoid features of the carcinoma compatible with high-grade urothelial carcinoma. (Figure 5) Chemotherapy (MVAC regimen) was prescribed as follow: methotrexate 30 mg/m2 on days 1, 15 and 22; vinblastine 3 mg/m2 on days 2, 15 and 22, doxorubicin 30 mg/m2 on day 2 and cisplatin 70 mg/m2 on day 2, every 28 days each cycle. After 3 cycles, the patients showed marked relief of pain and notably decrease of the suprapubic and scrotal swelling. DISCUSSION In 1991, Sahin et al.1 described the first case of plasmocytoid variant urothelial carcinoma (PVUC) of the bladder in a 63-year-old-man presenting a bladder tumor and multiple lytic bone lesions with histologic appearance that mimicked multiple myeloma. This neoplasm is a rare variant of transitional cell carcinoma. Figure 1. Axial pelvic CT showing bladder wall thickening (arrow). Recently, case series and case reports concerning this carcinoma variant have been published. 2,3 Data regarding PVUC show that this neoplasm presents a distinctive clinical outcome represented by high aggressiveness and poor survival rate.2-4 The number of case reports increased during the last decade, what Figure 2. Photomicrography of the bladder tumor - A - Invasive carcinoma with plasmocytoid features (HE, 100X); B - Detail of tumor cells spread in single cell formation (HE, 200X); C and D - Detail of tumor cells spread in Indian file (HE, 400X). 58

A - showing densification of adipose tissue and muscle layers of the anterior abdominal (arrows); B - extension of the infiltration to the scrotum.

3 Fonseca LG, Souza CE, Mattedi RL, Girardi DM, Sarkis AS, Hoff PMG Figure 3. Photomicrography of the bladder tumor - Immunohistochemistry. A - CD138 positive staining (400x); B - CK34BE12 positive staining (400x); C - E-cadherin negative staining (400x); D - p63 negative staining (400x). Figure 4. Axial CT of the pelvis. A - showing densification of adipose tissue and muscle layers of the anterior abdominal (arrows); B - extension of the infiltration to the scrotum. raised the suspicion of an unrecognized ongoing causative factor or a better recognition of this variant could explain this increment. Histopathological characteristics of PVUC show eccentrically placed nucleus and abundant eosinophilic cytoplasm. Nuclear grade are usually low to intermediate, with occasional pleomorphism. The tumor cells spread in single cell formation, known as Indian file, along nerve bundles. 2,5,6 Immunohistochemical profile of PVUC is characterized by positivity for CD138, a marker shared with myeloma cells. The cell adhesion marker E-cadherin is downregulated, suggesting a possible role of epithelialmesenchymal transition event in PVUC carcinogenesis. Loss of E-cadherin may also allow the discohesive nature of PVUC cells to invade into surrounding tissue, along fascial planes and draining lymph nodes.7 MUM-1 positivity, which occurs in myeloma cells, has not been observed in PVUC.5 Immunohistochemical markers considered specific for urothelial lineage was observed in PVUC in an analysis involving variants of urothelial carcinoma, such 59

4 Plasmacytoid urothelial carcinoma: a case of histological variant of urinary bladder cancer with aggressive behavior Figure 5. A - Carcinoma infiltration of the subcutaneous adipose tissue (HE x 100); B - poorly cohesive and plasmocytoid features consistent with metastatic plasmacytoid carcinoma (HE x400). as GATA3 (100%), S-100P (100%), Thrombomodulin (45%), CK7 (70%), CK20 (60%), p63(54%), HMCK (90%) and uroplakin (8%).8 Although retrospective cohorts studies of tertiary referral centers have been published, there is still paucity of published data on the clinical behavior and treatment of this malignancy. In a recent retrospective analysis, Kaimakliotis et al.9 analyzed 624 patients submitted to radical cystectomy from 2008 to Among them, 25 patients were diagnosed with PVUC. Positive paravesical margins, urethral surgical margins and lymph node involvement were higher in PVUC than in nonvariant subtype. These results indicated more aggressiveness of local spread and called attention for surgeons and pathologists on surgical margins in PVUCs.9 Local treatment for non muscle-invasive bladder urothelial carcinoma is based on transurethral resection with or without intravesical BCG therapy according to high risk factors. Some authors, however, tend to recommend early cystectomy in patients with other urothelial carcinoma variants, such as PVUC, due to the high risk of relapse and aggressive local dissemination.10 Similarly, there is no standard recommendation for initial management of locally-advanced or muscleinvasive PVUC. Dayyani et al. 3 reported the MD Anderson Cancer Center experience with 31 patients with PVUC. Sixteen patients had potentially surgically resectable tumor, 5 of them received neoadjuvant chemotherapy, 10 underwent initial surgery and 1 was treated with transurethral resection. Among the 60 patients who received neoadjuvant chemotherapy, pathological down staging was present in 80%. However, there was no difference in the survival rate between patients that received initial surgery or neoadjuvant chemotherapy. The median survival rate of this cohort was 17.7 months; 45.8 months for stages I-III and 13.3 months for stage IV. Patients with metastatic disease at presentation were treated with chemotherapy and showed the median survival rate of 12.6 months. In this cohort the peritoneum was a common site of recurrence (19 of 23 patients). In other cohort of patients with muscle-invasive bladder tumor after cystectomy, median overall survival rate of patients with PVUC was 22 months, which was significantly lower comparing with patients with nonvariant carcinoma. Therefore, among patients selected for cystectomy, those with PVUC had increased risk of mortality at cystectomy.11 Polychemotherapy regimen MVAC has improved survival and overall response rate in comparison with single-agent cisplastin in randomized phase III trial for metastatic or unresectable urothelial bladder carcinoma.12 There is no consensus nor strong evidence regarding the use of specific chemotherapeutic agents in PVUC. However, in the present case, MVAC regimen provided rapid symptoms relief associated with reasonable tolerance. The aggressive behavior of the present case is in accordance with the literature showing the poor outcome associated with PVUC. Chemotherapy may play a role in disease control and relief of symptoms in unresectable or recurrent disease, as showed in the

5 Fonseca LG, Souza CE, Mattedi RL, Girardi DM, Sarkis AS, Hoff PMG present case. However, neoadjuvant chemotherapy did not seem to impact in long-term survival in the retrospective cohort aforementioned. 11 We believe that early diagnosis and radical surgical approach are pivotal for modifying the clinical course of this subtype of bladder carcinoma. A multidisciplinary team in referral centers is the ideal scenario for managing PVUC treatment. CONCLUSION We presented a case of PVUC, a rare histological variant of urothelial bladder carcinoma. The patient s clinical course is in accordance with the literature data in terms of locally aggressiveness of this tumor. Morphologic distinction of the plasmocytoid phenotype is critical for clinician awareness with regard to the risk for early regional and metastatic progression of the disease. REFERENCES 1. Sahin AA, Myhre M, Ro JY, Sneige N, Dekmezian RH, Ayala AG. Plasmacytoid transitional cell carcinoma. Report of a case with initial presentation mimicking multiple myeloma. Acta Cytol. 1991;35(3): PMid: Keck B, Stoehr R, Wach S, et al. The plasmacytoid carcinoma of the bladder rare variant of aggressive urothelial carcinoma. Int J Cancer. 2011;129(2): PMid: Dayyani F, Czerniak BA, Sircar K, et al. Plasmacytoid urothelial carcinoma, a chemosensitive cancer with poor prognosis, and peritoneal carcinomatosis. J Urol. 2013;189(5): juro PMid: Mai KT, Park PC, Yazdi HM, et al. Plasmacytoid urothelial carcinoma of the urinary bladder report of seven new cases. Eur Urol. 2006;50(5): org/ /j.eururo PMid: Lopez-Beltran A, Requena MJ, Montironi R, Blanca A, Cheng L. Plasmacytoid urothelial carcinoma of the bladder. Hum Pathol. 2009;40(7): org/ /j.humpath PMid: Raspollini MR, Sardi I, Giunti L, et al. Plasmacytoid urothelial carcinoma of the urinary bladder: clinicopathologic, immunohistochemical, ultrastructural, and molecular analysis of a case series. Hum Pathol. 2011;42(8): PMid: Erdemir F, Ozcan F, Kilicaslan I, Parlaktas BS, Uluocak N, Gokce O. The relationship between the expression of E-cadherin and tumor recurrence and progression in high-grade stage T1 bladder urothelial carcinoma. Int Urol Nephrol. 2007;39(4): s PMid: Paner GP, Annaiah C, Gulmann C, et al. Immunohistochemical evaluation of novel and traditional markers associated with urothelial differentiation in a spectrum of variants of urothelial carcinoma of the urinary bladder. Hum Pathol. 2014;45(7): org/ /j.humpath PMid: Kaimakliotis HZ, Monn MF, Cheng L, et al. Plasmacytoid bladder cancer: variant histology with aggressive behavior and a new mode of invasion along fascial planes. Urology. 2014;83(5): urology PMid: Porten SP, Willis D, Kamat AM. Variant histology: role in management and prognosis of nonmuscle invasive bladder cancer. Curr Opin Urol. 2014;24(5): PMid: Kaimakliotis HZ, Monn MF, Cary KC, et al. Plasmacytoid variant urothelial bladder cancer: is it time to update the treatment paradigm? Urol Oncol. 2014;32(6): PMid: Loehrer PJ Sr, Einhorn LH, Elson PJ, et al. A randomized comparison of cisplatin alone or in combination with methotrexate, vinblastine, and doxorubicin in patients with metastatic urothelial carcinoma: a cooperative group study. J Clin Oncol. 1992;10(7): PMid: Conflict of interest: None Submitted on: September 10, 2014 Accepted on: November 17, 2014 Correspondence Instituto do Câncer do Estado de São Paulo (ICESP) Av. Dr. Arnaldo, 251 São Paulo/SP Brazil CEP: Phone +55 (11) leogfonseca@hotmail.com 61

Plasmacytoid Variant Urothelial Carcinoma: Diagnostic and Grossing Challenges. Kailyn Gibson MS, PA-ASCP, Congli Wang, MD

1 Plasmacytoid Variant Urothelial Carcinoma: Diagnostic and Grossing Challenges Kailyn Gibson MS, PA-ASCP, Congli Wang, MD Johns Hopkins Hospital Department of Surgical Pathology 2 Plasmacytoid Variant