Genetic Aspects of Inherited colorectal cancer (CRC)
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1 Genetic Aspects of Inherited colorectal cancer (CRC) New data New insights DNA repair Cancer Hub 3/2014
2 2004 Service for genetics of GI Cancer Oncology Tamar Peretz A. Hubert L. Kadouri N. Halpern M. Plesser Tamar Hamburger Genetic I. Lerer D. Abeliovich L. Ben Avi V. Meiner M. Sagi A. Eilat Pathology E. Pikarsky H. Goldshmith E. Ben Avraham R. Porat Surgery A.Nissan A. Pikarsky Gynecology Gastroenterology Rabin Medical Center TASMC K. Wimmer I. Tomlinson * The Israeli Cancer Association
3 GI-Oncogenetic Service in Hadassah
4 GI-Oncogenetic Service in Hadassah 1782 Patients > 1338 Families 124 Lynch families 3 C-MMRD families 7 MYH families 1 HMPS FAP, BMPR1A, STK11, P53 BRCA1 /BRCA2
5 GI-Oncogenetic Service in Hadassah Dedicated service for Surveillance: Healthy carriers special surveillance protocols; chemoprevention, disease biomarkers Affected patients personalized medicine High risk undiagnosed patients Ongoing diagnostic efforts
6 Colon Cancer can be prevented Early detection improves prognosis Aspirin reduced risk for CRC - CAPP1, 2, 3.. Normal epithelium Adenoma Carcinoma Metastases Multistep process Cancer Hub 3/2014
7 Inherited CRC A relatively large number of monogenic syndromes associated with a high lifetime risk of CRC. Normal epithelium Adenoma Carcinoma Metastases
8 Genetic Aspects of Inherited colorectal cancer (CRC) New data New insights DNA repair Variety of Syndromes and Genes Lynch Syndrome MSI in colon cancer Cancer Hub 3/2014
9 Inherited CRC HNPCC FAP (APC) Rare Polyposis Syndromes Cowden's disease (PTEN) PJS (STK11) JPS (SMAD4, BMPR1A) Adapted from Burt RW et al. Prevention and Early Detection of CRC Cancer Hub 3/2014
10 Inherited CRC HNPCC - Lynch / Syndrome X FAP (APC) MAP (MutYH) PPAP (POLE POLD1) Rare Polyposis Syndromes Cowden's disease (PTEN) PJS (STK11) JPS (SMAD4, BMPR1A) HMPS Adapted from Burt RW et al. Prevention and Early Detection of CRC Cancer Hub 3/2014
11 COLOSEQ NGS PANEL (UW) Gene Disease Association or Cancer Risk Complete Sequencing Del/Dup Added MLH1 Lynch, Muir-Torre Yes Yes November 2011 MSH2 Lynch, Muir-Torre Yes Yes November 2011 MSH6 Lynch Yes Yes November 2011 PMS2 Lynch Yes Yes November 2011 EPCAM Lynch Yes Yes November 2011 APC FAP, Turcot Yes Yes November 2011 MUTYH MAP Yes Yes November 2011 CDH1 HDGC Yes Yes June 2012 PTEN Cowden Yes Yes June 2012 STK11 Peutz-Jeghers Yes Yes June 2012 TP53 Li-Fraumeni Yes Yes June 2012 SMAD4 Juvenile Polyposis Yes Yes January 2013 BMPR1A Juvenile Polyposis Yes Yes January 2013 POLE Colon, endometrial cancer Yes Yes NEW October 2013 POLD1 Colon cancer Yes Yes NEW October 2013 GALNT12 Colon cancer Yes Yes NEW October 2013 GREM1 Polyposis Yes Yes NEW October 2013 AKT1 PIK3CA Breast, thyroid cancers, macrocephaly Breast, thyroid cancer, macrocephaly Yes Yes NEW October 2013 Yes Yes NEW October 2013
12 Post-GWAS science: GWAS have discovered over 100 haplotypetagging SNPs that are associated with cancer risk. Accumulation of functional evidence Cancer Hub 3/2014
13 Next-Generation Sequencing (NGS) ERA: Analyze entire human genome in a clinically useful time frame Faster & cheaper generation of data, increased accuracy Sufficient for clinical application NGS does not cover variety of complex gene@c aberra@ons : CNVs, structural changes, epigenomic changes post-sequencing analysis Bioinformatics
14 COLOSEQ NGS PANEL (UW) Gene Disease Association or Cancer Risk Complete Sequencing Del/Dup Added MLH1 Lynch, Muir-Torre Yes Yes November 2011 MSH2 Lynch, Muir-Torre Yes Yes November 2011 MSH6 Lynch Yes Yes November 2011 PMS2 Lynch Yes Yes November 2011 EPCAM Lynch Yes Yes November 2011 APC FAP, Turcot Yes Yes November 2011 MUTYH MAP Yes Yes November 2011 CDH1 HDGC Yes Yes June 2012 PTEN Cowden Yes Yes June 2012 STK11 Peutz-Jeghers Yes Yes June 2012 TP53 Li-Fraumeni Yes Yes June 2012 SMAD4 Juvenile Polyposis Yes Yes January 2013 BMPR1A Juvenile Polyposis Yes Yes January 2013 POLE Colon, endometrial cancer Yes Yes NEW October 2013 POLD1 Colon cancer Yes Yes NEW October 2013 GALNT12 Colon cancer Yes Yes NEW October 2013 GREM1 Polyposis Yes Yes NEW October 2013 AKT1 PIK3CA Breast, thyroid cancers, macrocephaly Breast, thyroid cancer, macrocephaly Yes Yes NEW October 2013 Yes Yes NEW October 2013
15 Hereditary mixed polyposis syndrome Jaeger E Tomlinson I.Nat Genet Ashkenazi kindreds with HMPS Autosomal Dominant multiple types of colorectal polyps, with CRC. Linkage analysis - A shared haplotype on chromosome 15q13.3 Sequencing the coding regions - no novel pathogenic changes search for CNV in the region - a heterozygous duplication of 40kb on chr 15 at the 3' end of the SCG5 gene An Ashkenazi founder mutation GREM1 expression in colon epithelium BMP pathway activity
16 Gene Disease Association or Cancer Risk Complete Sequencing Del/Dup Added MLH1 Lynch, Muir-Torre Yes Yes November 2011 MSH2 Lynch, Muir-Torre Yes Yes November 2011 MSH6 Lynch Yes Yes November 2011 PMS2 Lynch Yes Yes November 2011 EPCAM Lynch Yes Yes November 2011 APC FAP, Turcot Yes Yes November 2011 MUTYH MAP Yes Yes November 2011 CDH1 HDGC Yes Yes June 2012 PTEN Cowden Yes Yes June 2012 STK11 Peutz-Jeghers Yes Yes June 2012 TP53 Li-Fraumeni Yes Yes June 2012 SMAD4 Juvenile Polyposis Yes Yes January 2013 BMPR1A Juvenile Polyposis Yes Yes January 2013 POLE Colon, endometrial cancer Yes Yes NEW October 2013 POLD1 Colon cancer Yes Yes NEW October 2013 GALNT12 Colon cancer Yes Yes NEW October 2013 GREM1 Polyposis Yes Yes NEW October 2013 AKT1 PIK3CA Breast, thyroid cancers, macrocephaly Breast, thyroid cancer, macrocephaly COLOSEQ PANEL Three pathways involved in the repair of base pair-level mutations can predispose to CRC Yes Yes NEW October 2013 Yes Yes NEW October 2013
17 MUTYH-associated polyposis (MAP) MUTYH - a post-replicative DNA glycosylase Base excision repair (BER) repairs the majority of endogenous DNA damages (deaminations, depurinations, alkylations & oxidative damages) A signature of a defect in MUTYH is high proportion of GC TA transversions in tumor target genes APC & KRAS Cancer Hub 3/2014
18 MUTYH-associated polyposis (MAP) Autosomal recessive CRC Germline bi-allelic mutations in MYH predispose to multiple adenoma or polyposis coli. Phenotype is similar to attenuated FAP Cancer Hub 3/2014
19
20 Germline and somatic POLE & POLD1 mutations define a new class of hypermutated CRC & EC Sarah Briggs & Ian Tomlinson, J Pathol 2013 polymerase proofreading-associated polyposis (PPAP). A combination of whole-genome sequencing, linkage analysis, and studies of LOH Exonuclease domain (EDM) improves replication fidelity approximately 100-fold. Germline EDM mutations confer a high risk of multiple adenomas and CRC. POLD1 mutations also predispose to Endometrial cancer. ultramutated microsatellite-stable, cancer (> a million base substitutions/ tumor) Dominant inheritance Variable phenotype Cancer Hub 3/2014
21 The features of tumor mutations can indicate an inherited condition PPAP - ultramutated microsatellite-stable (mss) cancer MAP Exess of transvertions in tumor Lynch (MMR) - microsatellite-unstable (MSI), wtbraf tumors Sporadic MSI - microsatellite-unstable (MSI), mbraf tumors HMPS over expression of GREM1
22 Genetic Aspects of Inherited colorectal cancer (CRC) New data New insights DNA repair New data & perspective Variety of Syndromes and Genes Lynch Syndrome MSI tumors Cancer Hub 3/2014
23 100 years for Lynch Syndrome Warthin s report on Cancer Family Syndrome 1960 Henry Lynch re-identifying the syndrome 1993 The genetics behind Cancer Hub 3/2014
24 100 years for Lynch Syndrome Warthin s report on Cancer Family Syndrome 1960 Henry Lynch re-identifying the syndrome 1:1000 1:370 Hampel, H. & A. de la Chapelle, Cancer prevention research, (1): p ,800,000 carriers worldwide 61,700 newly diagnosed Lynch related CRC worldwide Jemal, A., et al., Cancer statistics, CA Cancer J Clin, (5): p LS is seriously under-diagnosed. <5 % of high risk patients received LS testing *Cross et al, Genet Med. 2013
25 Lynch Syndrome in Israel Incidence? 3 founder mutations among Ashkenazi 1 founder mutation among Jews from Georgia 3 recurrent mutations amon g jews from Afgamistan, Iran, Ethiopia Co-occurrence of BRCA and Lynch * Bias!
26 Cancer Risks in Carriers by 70y Compared to the General Population Cancer General population risk Risks Lynch Mean Age of Onset Colon 5.5% 80% 44 years Endometrium % <60% 46 years Stomach <1% % 56 years Ovary 1-1.6% 9-12% 42.5 years Hepatobiliary tract <1% 2-7% Not reported Urinary tract <1% 4-5% ~55 years Small bowel <1% 1-4% 49 years Brain/central nervous system <1% 1-3% ~50 years
27 Benefit of Surveillance (Jervinen 1995, 2000) 2-3y surveillance intervals A 63% reduction in the incidence of CRC A 65% reduction in overall mortality Gastroenterology (Vasen et. al) A cumulative risk of 6% after 10-years. Risk for advanced cancer was 0.6% after 10-years Screening for MMR is cost-effectiveness Cancer Prev Res (Phila) (Vasen et. al)
28 Colon Cancer can be prevented
29 Cancer Risks in Carriers by 70y Compared to the General Population Extracolonic cancer: Gene dependent MSH6>MSH2>MLH1 Tissue selectivity? Modifier genes? Target genes? Environment? Epigenetic?
30 MMR- Mutation Mismatch Repair MMR proteins recognize and repair base pair mismatches that occur during DNA replication - DNA caretakers MSH2 MMR-work in pairs MSH6 MLH1 PMS2 Cancer Hub 3/2014
31 Microsatellite instability (MSI) MMR Loss IDLs Microsatellite instability Genes with microsatellites in coding regions are at risk Target genes*: TGFBRII (PolyA 10) BAX (G8) IGFRIIR (G8) MSH3 (A)8 MSH6 TCF4 Cancer Hub 3/2014
32 Carrier LOH Cancer Hub 3/2014
33 Tumor Testing Surrogate Biomarker MSI Cancer Hub 3/2014
34 Mechanisms for LOH? LOH Cancer Hub 3/2014
35 The role of epigenetics in Lynch no pathogenic mutation is identifiable in 33% of cases with LS. Primary epimutation of MLH1 shows non-mendelian inheritance patterns varying from: apparent heritability to the reversion of the methylated allele Primary epimutation on MLH1 The role of epigenetics in Lynch syndrome Megan P. Hitchins. FamCan.2013 Cancer Hub 3/2014
36 The role of epigenetics in Lynch EPCAM 1-3% PMS2 <5% MLH % MSH2 50% Cancer Hub 3/2014
37 CMMR-D Autosomal recessive LS 2 8 Bladder Cancer Endometrial Cancer Colon Cancer MMR-D Carrier of c.686_687delct mutation in PMS2 Toledano, Goldberg, et al. FamCan. 2009
38 Microsatellite instability (MSI) Inactivation of the MMR system Either by: MMR gene mutations-inherited (1/3) Hypermethylation of MLH1 promoter-sporadic (2/3) Cancer Hub 3/2014
39 The Genomic Pathogenesis of Colorectal Cancer CIN 85 % Normal epithelium APC, K-ras 12p, DCC 18q, p53 17p,.. Adenoma Carcinoma Metastases hmlh1, hmsh2, TGF-ß RII, Bax, TCF4, ACVRII, Caspase 5. MSI 15 %
40 MSI cancers are relatively insensitive to 5-fluorouracil In vivo: Prognostic- those with tumors displaying MSI-H had a better five-year rate of overall survival. Predictive- There was no benefit of adjuvant chemotherapy in the group with MSI-H. Ribic et al, N Engl J Med, 2003 Cancer Hub 3/2014
41 Targeted therapies based on molecular alterations in MSI+ CRC Yamamoto et al. World J Gastroenterol 2012 Cancer Hub 3/2014
42 Thank you
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