The Challenge of Accelerating Medical Solutions Through Philanthropy. Steve Case, Case Foundation Mike Milken, FasterCures

Transcription

1 The Challenge of Accelerating Medical Solutions Through Philanthropy Steve Case, Case Foundation Mike Milken, FasterCures

2 U.S. BABY BOOMERS Sources: MetLife Mature Market Institute Analysis U.S. Census Bureau

3 Berkeley 1964

4 Who are the Baby Boomers?

5 Who are the Baby Boomers? 78 million Americans 27.5% of U.S.

6 Who are the Baby Boomers? $1.1 trillion in spending power

7 Who are the Baby Boomers? 28.5% have college degrees

8 Who are the Baby Boomers? 69% own their homes

9 Number of U.S. Non-Profit Organizations (millions)

10 Growth of U.S. Non-Profit Organizations (millions)

11 Charitable Giving 2003 Total Size: $ Billion Public-Society Benefit 5% International Environment Affairs & Animals 2% 3% Foundations 9% Religion 36% Arts, Culture & Humanities 5% Unallocated Giving 10% Human Services 8% Health 9% Education 13%

12 Charitable Giving 2003 By Type of Receipt Organization Total Size: $ Billion Public-Society Benefit $ % Arts, Culture, Humanities $ % Environment & Animals $6.95 3% Int l Affairs $5.3 2% Foundations $ % Religion $ % Unallocated Giving $ % Human Services $ % Health $ % Education $ %

13 Charitable Giving 2003 Total Size: $ Billion Bequests 9% Foundations 11% Corporations 6% Individuals 74%

14 Large Philanthropic Grants (Number of grants for $10 million or more) Source: Foundation Center

15 Worldwide Life Expectancy Growth Years 26 Years Years 49 Years United Nations Development Program

16 Between 1900 and 2000, life expectancy in the U.S. increased 54%, from 50 to 77 years. Sources: Centers for Disease Control

17 Healthcare Percent of U.S. GDP 18% 17.7% by % 12% 8% 4% Source: U.S. Department of Health and Human Services 2012

18 Lifestyle Makes a Difference 15% = health care spending $1.7 trillion U.S. Economy $11 trillion

19 Lifestyle Makes a Difference 70% of health-care spending $1 trillion is spent on lifestyle-related diseases. U.S. Economy $11 trillion

20 Obese U.S. Children Ages 6 to 11 9M 6M 3M 1970s Today Source: Institute of Medicine

21 Obese U.S. Children Ages 6 to 11 As a result, there has been a ten-fold increase in type-2 diabetes in children in just 10 years. This could produce the first decline in average lifespans in 200 years! Source: Institute of Medicine

22

23 Only in America

24 Obesity is a factor in 16% of U.S. cancer deaths. That s 90,000 deaths each year. Source: American Cancer Society

25 Lifetime Risks of Cancer in the U.S. Women: 1 in 3

26 Lifetime Risks of Cancer in the U.S. Men: 1 in 2

27 New Cancer Cases U.S. Men 2004 Colorectal 11% Urinary 6% Lung 13% Non-Hodgkins lymphoma 4% Other 32.8% Prostate 33%

28 Lifetime Risks of Prostate Cancer in the U.S. Men: 1 in 6

29 Heart Diseases Deaths vs. Cancer Deaths Heart Disease Cancer Source: FORTUNE magazine / March 2004

30 Cancer Death Rates Death per 100,000, age adjusted 60 Lung 40 Prostate 20 Colon Breast Source: FORTUNE / NCI, SEER Database

31 Leveraging Philanthropic Investment Total spent on prostate cancer research $25 million <$500 million

32 The March

33 The March

34 Andrew Von Eschenbach 1993 PCF Awardee Current Director, NCI I'll never forget that evening back in Walking up the Capitol steps and seeing that beautiful light on the dome and the gleaming white marble, I was awestruck. I couldn't believe that this kid from South Philly was walking into the Capitol of the United States of America and actually going to have dinner there. I only wish that my Dad, who died from prostate cancer, could have been there with me. But in a way he was.

35 PCF Therapy Consortium

36 Prostate Cancer Foundation Therapy Consortium Cedars-Sinai Prostate Cancer Center Dana-Farber Cancer Institute Johns Hopkins University Medical Institutions M.D. Anderson Cancer Center Memorial Sloan-Kettering Cancer Center University of California, San Francisco University of Michigan Comp. Cancer Center University of Wisconsin Medical School

37 PCF Therapy Consortium

38 2004 Nobel Prize in Chemistry Aaron Ciechanover The Technion, Haifa, Israel

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40 Economic Value of Eliminating Deaths $50T $48.4T $46.5T $57T H E A R T D I S E A S E C A N C E R $7.6T $7.5T U.S. B A L A N C E S H E E T STROKE AIDS Source: Kevin M. Murphy and Robert H. Topel/University of Chicago

41 Value of Life by Age in 1990 US$ Millions Males Females Age Source: Kevin M. Murphy and Robert H. Topel/University of Chicago

42 The 21 st Century will see a worldwide competition for human capital.

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44 Comparing Orders of Magnitude Shrek $450M 1

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47 Comparing Orders of Magnitude Shrek $450M 1 DJ/NYT/Wash Post average $5B 10 Yahoo + Google average $53B 100 Cure of cancer $47T 100,000 U.S. human capital $900T 2,000,000 World human capital $3,600T 8,000,000

48 Genentech 2005 Stock Price Avastin approved for lung cancer Avastin effective for breast cancer 3/15 3/16 4/14 4/15 $45.9 B Market Cap $72.5 B

49 Can we accelerate medical solutions?

50 An organization dedicated to shortening the time to find cures and better treatments for the most deadly and debilitating diseases.

51

52 In theory, 300 mph

53 In practice, same speed as 100 years ago.

54 19 th /20 th -Century Tracks 19 th /20 th -Century Thinking

55 Revolution Occurring in Medicine Reactive Predictive Preventive

56 Estimated Cost of Sequencing a Gene 1974 >$100,000, $ $ $ $0.03 (That s faster than Moore s Law.) Source: Dr. David Agus-Cedars-Sinai; Dr. Leroy Hood, Institute for Systems Biology

57 Financial Data Were Accessible

58 Medical Data Research Genomics Clinical Trials

59 One Person Cannot Do It

60 Two People Cannot Do It

61 Two People Cannot Do It It Takes Teamwork

62 Lance Armstrong José Azevedo Michael Barry Manuel Beltran Fumiyuki Beppu Volodymyr Bileka Janez Brajkovic Michael Creed Antonio Cruz Tom Danielson Stign Devolder Viatcheslav Ekimov Roger Hammond Ryder Hesjedal George Hincapie Benoît Joachim Jason McCartney Patrick McCarty Gennady Mikhailov Benjamin Noval Yaroslav Popovych Hayden Roulston José Luis Rubiera Paolo Savoldelli Jurgen Van den Broeck Max Van Heeswijk