NGF count. Threshold estimates: 411 NGFs 604 NGFs 501 NGFs age (years)

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Bennett Baldwin
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1 NGF count Threshold estimates: 411 NGFs 604 NGFs 501 NGFs age (years)

2 Regression model for NGF count and age: mean of log(ngf count): 12.29(0.16) (0.015) age ( ) age 2 standard deviation of log (NGF count): exp{ 0.45(0.12) (0.0042) age} Derived distribution of menopausal ages: critical NGF count threshold: 498(88) standard deviation of log (NGF count): exp{ 0.81(0.19) (0.0042) age} Both models: skewness of log(ngf count) residual distribution: 0.33(0.037) Supplemental Figure 2. Maximum likelihood parameter estimates (with standard errors in brackets) of components of the model for declining NGF count with increasing age and the derived distribution of menopausal ages from the NGF count falling below a critical threshold.

3 Supplemental Table 1 Specimen Publication Age NGF Count Medical condition allowing ovary removal Age source date single ovary Group Hansen perinatal asphyxia 0 Hansen diaphragmatic hernia 0 Hansen congenital heart failure 0 Hansen ,5 sepsis 0 Forabosco cranial trauma 0 Hansen asthma attack 0 Hansen congenital heart failure 0 Block sudden death 0 Block sudden death 0 Block sudden death 0 Block sudden death 0 Hansen pulmonary hypertension 0 Block sudden death 0 Hansen head injury 0 Hansen hydrocephaly 0 Block sudden death 0 Hansen asphyxiation 0 Block sudden death 0 Block sudden death 0 Hansen ,5 motor vehicle accident 0 Hansen motor vehicle accident 0 Block sudden death 0 Hansen drug overdose 0 Hansen intracranial hemorrhage 1 Hansen motor vehicle accident 1 Block sudden death 1 Hansen motor vehicle accident 1 Hansen motor vehicle accident 1 Hansen ,5 cerebrovascular accident 1 Block sudden death 1 Block sudden death 1 Hansen motor vehicle accident 1 Block sudden death 1 Gougeon surgery for breast cancer, cervical cancer, fibroadenomas 1 Hansen motor vehicle accident 1 Block sudden death 1 Block sudden death 1 Hansen motor vehicle accident 1 Hansen motor vehicle accident 1 Hansen ,5 motor vehicle accident 1

4 Hansen ,5 pelvic pain/ endometriosis 1 Hansen seizure 1 Hansen motor vehicle accident 1 Block sudden death 1 Hansen pelvic pain/ endometriosis 1 Hansen pelvic pain/ endometriosis 1 Block sudden death 1 Hansen cerebrovascular accident 1 Block sudden death 1 Block sudden death 1 Gougeon surgery for breast cancer, cervical cancer, fibroadenomas 1 Hansen head trauma 1 Hansen dysmenorrhea, fibroids 1 Block sudden death 1 Hansen ,5 pulmonary embolism 1 Block sudden death 1 Hansen motor vehicle accident 1 Block sudden death 1 Block sudden death 1 Hansen pelvic pain/ endometriosis 1 Block sudden death 1 Hansen ,5 pulmonary embolism 1 Hansen pelvic pain 1 Hansen pelvic pain/ endometriosis 1 Block sudden death 1 Hansen pelvic pain/ endometriosis 2 Block sudden death 2 Block sudden death 2 Block sudden death 2 Gougeon surgery for breast cancer, cervical cancer, fibroadenomas 2 Hansen ,5 carotid artery aneurysm 2 Hansen pulmonary embolism 2 Hansen pelvic pain 2 Block sudden death 2 Block sudden death 2 Block sudden death 2 Hansen ,5 head trauma 2 Hansen pelvic pain/ endometriosis 2 Hansen cerebrovascular accident 2 Hansen menorrhagia/ endometriosis 2 Hansen motor vehicle accident 2 Block sudden death 2 Block sudden death 2

5 Hansen pelvic pain/ adenomyosis 2 Gougeon surgery for breast cancer, cervical cancer, fibroadenomas 2 Hansen ,5 pelvic pain/ endometriosis 2 Hansen pelvic pain 2 Gougeon surgery for breast cancer, cervical cancer, fibroadenomas 2 Gougeon surgery for breast cancer, cervical cancer, fibroadenomas 2 Hansen ,5 pelvic pain/ endometriosis 2 Hansen cerebral aneurysm 2 Hansen endometriosis 2 Hansen endometriosis 2 Hansen pelvic pain 2 Block sudden death 2 Gougeon surgery for breast cancer, cervical cancer, fibroadenomas 2 Gougeon surgery for breast cancer, cervical cancer, fibroadenomas 2 Hansen ,5 motor vehicle accident 2 Hansen dysmenorrhea, pelvic pain 2 Hansen cerebrovascular accident 2 Block sudden death 2 Hansen endometriosis, fibroids 2 Hansen pelvic pain, fibroids 2 Hansen pelvic pain/ endometriosis 2 Hansen dysmenorrhea/ adenomyosis 2 Hansen pelvic pain/ adenomyosis 2 Block sudden death 2 Gougeon surgery for breast cancer, cervical cancer, fibroadenomas 2 Hansen endometriosis/ adenomyosis 2 Hansen menorrhagia 2 Hansen ,5 pelvic pain/ adenomyosis 2 Hansen pelvic pain/ endosalpingitis 2 Hansen ,5 pelvic pain/ endometriosis 2 Hansen pelvic pain/ adhesions 2 Hansen cerebrovascular accident 2 Hansen motor vehicle accident 2 Gougeon surgery for breast cancer, cervical cancer, fibroadenomas 2 Gougeon surgery for breast cancer, cervical cancer, fibroadenomas 2 Hansen cerebral aneurysm 2 Block sudden death 2 Block sudden death 2 Gougeon surgery for breast cancer, cervical cancer, fibroadenomas 2 Hansen cerebral aneurysm 2 Hansen menorrhagia/ fibroids 2 Hansen ,5 menorrhagia/ fibroids 2 Block sudden death 2

6 Hansen ,5 menorrhagia/ fibroids 2 Hansen pelvic pain/ fibroids 2 Hansen menometrorrhagia/ fibroids 2 Hansen pelvic pain/ menorrhagia 2 Hansen menorrhagia/ fibroids 2 Hansen menorrhagia/ fibroids 2 Block sudden death 2 Gougeon surgery for breast cancer, cervical cancer, fibroadenomas 2 Hansen ,5 pelvic pain/ endometriosis 2 Hansen pelvic pain/ endometriosis 2 Hansen ,5 dysmenorrhea/ fibroids 2 Hansen menorrhagia 2 Hansen menorrhagia/ fibroids 2 Block sudden death 2 Block sudden death 2 Gougeon surgery for breast cancer, cervical cancer, fibroadenomas 2 Gougeon surgery for breast cancer, cervical cancer, fibroadenomas 2 Hansen ,5 menorrhagia/ fibroids 2 Hansen cardiac arrest 2 Hansen menorrhagia/ adenomyosis 2 Hansen hydrosalpinx, fibroids 2 Hansen menorrhagia/ fibroids 2 Hansen pelvic pain 2 Hansen menorrhagia/ fibroids 2 Block sudden death 2 Gougeon surgery for breast cancer, cervical cancer, fibroadenomas 2 Gougeon surgery for breast cancer, cervical cancer, fibroadenomas 2 Gougeon surgery for breast cancer, cervical cancer, fibroadenomas 2 Gougeon surgery for breast cancer, cervical cancer, fibroadenomas 2 Gougeon surgery for breast cancer, cervical cancer, fibroadenomas 2 Hansen cerebrovascular accident 2 Hansen ,5 menorrhagia 2 Hansen endometrial hyperplasia 2 Hansen ,5 menorrhagia/ fibroids 2 Hansen pelvic pain/ endometriosis 2 Hansen ,5 menorrhagia/ fibroids 2 Hansen pelvic pain/ fibroids 2 Hansen menorrhagia 2 Hansen ,5 menorrhagia/ fibroids 2 Hansen ,5 menorrhagia/ fibroids 2 Hansen menorrhagia/ fibroids 2 Hansen ,5 pelvic pain 2 Richardson elective hysterectomy/oophorectomy 2

7 Richardson elective hysterectomy/oophorectomy 2 Gougeon surgery for breast cancer, cervical cancer, fibroadenomas 2 Gougeon surgery for breast cancer, cervical cancer, fibroadenomas 2 Gougeon surgery for breast cancer, cervical cancer, fibroadenomas 2 Gougeon surgery for breast cancer, cervical cancer, fibroadenomas 2 Gougeon surgery for breast cancer, cervical cancer, fibroadenomas 2 Hansen ,5 sepsis 3 Hansen menorrhagia/ adenomyosis 3 Hansen menorrhagia/ fibroids 3 Richardson elective hysterectomy/oophorectomy 3 Richardson elective hysterectomy/oophorectomy 3 Richardson elective hysterectomy/oophorectomy 3 Gougeon surgery for breast cancer, cervical cancer, fibroadenomas 3 Gougeon surgery for breast cancer, cervical cancer, fibroadenomas 3 Gougeon surgery for breast cancer, cervical cancer, fibroadenomas 3 Gougeon surgery for breast cancer, cervical cancer, fibroadenomas 3 Gougeon surgery for breast cancer, cervical cancer, fibroadenomas 3 Gougeon surgery for breast cancer, cervical cancer, fibroadenomas 3 Hansen pelvic pain/ fibroids 3 Hansen incontinence, fibroids 3 Richardson elective hysterectomy/oophorectomy 3 Richardson elective hysterectomy/oophorectomy 3 Richardson elective hysterectomy/oophorectomy 3 Gougeon surgery for breast cancer, cervical cancer, fibroadenomas 3 Gougeon surgery for breast cancer, cervical cancer, fibroadenomas 3 Gougeon surgery for breast cancer, cervical cancer, fibroadenomas 3 Gougeon surgery for breast cancer, cervical cancer, fibroadenomas 3 Gougeon surgery for breast cancer, cervical cancer, fibroadenomas 3 Gougeon surgery for breast cancer, cervical cancer, fibroadenomas 3 Hansen menorrhagia/ fibroids 3 Hansen menorrhagia/ fibroids 3 Hansen pelvic pain/ menorrhagia 3 Gougeon surgery for breast cancer, cervical cancer, fibroadenomas 3 Gougeon surgery for breast cancer, cervical cancer, fibroadenomas 3 Hansen pelvic pain/ adenomyosis 3 Hansen menorrhagia/ fibroids 3 Richardson elective hysterectomy/oophorectomy 3 Richardson elective hysterectomy/oophorectomy 3 Richardson elective hysterectomy/oophorectomy 3 Gougeon surgery for breast cancer, cervical cancer, fibroadenomas 3 Hansen ,5 abnormal uterine bleeding 3 Hansen dysmenorrhea/ endometriosis 3 Richardson elective hysterectomy/oophorectomy 3

8 Gougeon surgery for breast cancer, cervical cancer, fibroadenomas 3 Gougeon surgery for breast cancer, cervical cancer, fibroadenomas 3 Gougeon surgery for breast cancer, cervical cancer, fibroadenomas 3 Hansen ,5 menorrhagia/ fibroids 3 Hansen menorrhagia/ adenomyosis 3 Richardson elective hysterectomy/oophorectomy 3 Supplementary table 1: Outline of the NGF dataset (Age Category: 0=0-15, 1=16-30, 2=31-45, 3=46-60)

STEPHEN P. NONN OFFICE OF THE CORONER MADISON COUNTY, ILLINOIS 157 MAIN STREET SUITE 354 EDWARDSVILLE, IL

MAIN OFFICE: (618) 692-7478 MORGUE: (618) 296-4525 FAX: (618) 692-6042 FAX: (618) 692-9304 STEPHEN P. NONN OFFICE OF THE CORONER MADISON COUNTY, ILLINOIS 157 MAIN STREET SUITE 354 EDWARDSVILLE, IL. 62025-1962