CINA Deluxe Data Quality Profile
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1 CINA Deluxe Data Quality Profile Date DQP produced: February 9, 2018 Variable examined: CS Site-Specific Factor 1 (SSF1): Estrogen Receptor (ER) (NAACCR Data Item #: 2880) CS Site-Specific Factor 2 (SSF2): Estrogen Receptor (PR) (NAACCR Data Item #: 2890) CS Site-Specific Factor 15 (SSF15): Human Epidermal Growth Factor Receptor 2 (HER2) (NAACCR Data Item #: 2869) Filters: Invasive and ductal carcinoma in situ cases (DCIS) were evaluated separately. Lymphoma, leukemia, DCO, and autopsy cases were excluded. SSF15 was evaluated for invasive cases only. Histology of invasive breast cancer was based on AJCC7 histology inclusion criteria Histology of DCIS cases used the following ICD-O-3 codes: 8201, 8230, 8401, 8453, , , 8507, , 8541, and 8543 Female only Diagnosis Years covered: Diagnostic years for SSF1 and SSF2 since both SSFs were required for the 5 years. Diagnostic years for SSF15 since it was required by NAACCR for cases diagnosed in 2011 and after. Cancer Sites: Breast Database citation: CINA Analytic File, , Expanded Races Number of Registries included: 48 State Registries plus DC Cancer Registry (Three registries including Minnesota, Nevada, and New Mexico that did not meet the NAACCR data quality for years 2010 to 2014 were excluded.) 1
2 Data Dictionary: NAACCR Data Dictionary 16 ( *Access V16 by selecting 16 from the dropdown box at the top left hand corner of the page. Members: Meichin Hsieh, Bin Huang, Ahmedin Jemal, Carol Kruchko, Xiangrong Li, Baozhen Qiao, Recinda Sherman, Helmneh Sineshaw, Brad Wohler, Manxia Wu, Xiaocheng Wu, Qingzhao Yu Contact Information: Manxia Wu, MD, MPH Phone: (770) Technical Notes: 1. The ER, PR and HER2 status were created separately based on the three data item of CS Site-Specific Factor1 (NAACCR Data Item #: 2880), CS Site-Specific Factor 2 (NAACCR Data Item #: 2890), and CS Site-Specific Factor15 (NAACCR Data Item #: 2869), respectively. The unknown ER and PR were defined by test result of unknown (codes 988, 996, 997, 998 and 999) or blank. The unknown HER2 was defined by test result of unknown (codes 988, 997, 998, and 999) or blank. 2. Upper Whisker: extends to largest data point within the boundary of Q * (Q3-Q1). 3. Diagnostic confirmation: Microscopic confirmed includes positive histology, positive cytology, and positive microscopic confirmation, method not specified. 4. Urban/Rural 2013: The definition of metropolitan area is based on county using 2013 Rural/Urban Continuum Code. Metropolitan area includes county metro area with population 1million, county metro area with population between 25,000 and 1 million, and county metro area with population <25, Since ASCO/NCCN recommendation on SSF1 and SSF2 for breast in situ are only optional for DCIS, there is an expected higher percentage of missing for SSF1 and SSF2 for breast DCIS. 2
3 abltable 1. Unknown CS SSF1(ER) status among female invasive breast cancer, February 9, Registry Level total 7.1% 6.0% 5.5% 4.8% 4.4% 5.5% 25-75% Percentile (IQR) 2.9%-6.6% 2.4%-5.1% 2.5%-4.8% 2.0%-4.5% 1.7%-4.2% 2.3%-4.9% Minimum 1.4% 1.0% 1.1% 0.9% 0.9% 1.2% Median 4.3% 3.8% 3.2% 2.9% 2.6% 3.4% Maximum 23.6% 18.6% 18.9% 14.8% 14.1% 17.9% Upper Whisker 12.2% 9.2% 8.3% 8.3% 8.0% 8.8% # outside of upper whisker All cases combined % Unk Race White 12, % 10, % 9, % 8, % 7, % 49, % Black 1, % 1, % 1, % 1, % 1, % 7, % AI/AN % % % % % % Asian or Pacific Islander % % % % % 1, % Unknown race % % % % % 1, % Age years 2, % 2, % 2, % 1, % 1, % 10, % years 4, % 4, % 3, % 3, % 3, % 19, % years 3, % 2, % 2, % 2, % 2, % 13, % 75+ years 4, % 3, % 3, % 3, % 2, % 17, % Dx Confirmation Microscopic confirmed 12, % 42, % 10, % 8, % 8, % 42, % Non-microscopic confirmed 1, % 4, % 1, % % % 4, % Unknown % 3, % % % % 3, % Type of reporting source Hospital inpatient/outpatient or clinic 11, % 10, % 9, % 8, % 7, % 46, % Rad treatment/medical oncology center % % % % % 1, % Laboratory only (hospital or private) % % % % % 3, % Physicians off/private med. practitioner 1, % % % % % 4, % Nursing/convalescent home/hospice % % % % % % Other hospital outpatient/surgery center % % % % % 3, % Urban/Rural 2013 Metro 12, % 10, % 9, % 8, % 8, % 50, % Non-Metro 2, % 2, % 2, % 1, % 1, % 10, % Unknown % % % % % % 3
4 30.0% Figure 1. Percentage of unknown ER status among female invasive breast cancer by registry, % 20.0% 15.0% 10.0% US average 5.5% 5.0% 0.0% US Registry ID 4
5 TablTable 2. Unknown CS SSF2 (PR) status among female invasive breast cancer, February 9, Registry Level total 7.5% 6.3% 5.7% 5.0% 4.6% 5.8% 25-75% Percentile (IQR) 3.4%-6.9% 2.6%-5.6% 2.7%-5.0% 2.2%-4.7% 2.0%-4.5% 2.6%-5.2% Minimum 1.8% 1.1% 1.3% 1.3% 1.1% 1.5% Median 4.6% 4.0% 3.4% 3.2% 2.9% 3.6% Maximum 23.9% 18.8% 19.2% 15.0% 14.3% 18.1% Upper Whisker 12.2% 10.1% 8.5% 8.5% 8.3% 9.1% # outside of upper whisker All cases combined Race White 12, % 11, % 10, % 8, % 8, % 51, % Black 1, % 1, % 1, % 1, % 1, % 7, % AI/AN % % % % % % Asian or Pacific Islander % % % % % 2, % Unknown race % % % % % 1, % Age years 2, % 2, % 2, % 1, % 1, % 10, % years 4, % 4, % 3, % 3, % 3, % 20, % years 3, % 2, % 2, % 2, % 2, % 14, % 75+ years 4, % 3, % 3, % 3, % 2, % 18, % Dx Confirmation Microscopic confirmed 13, % 11, % 10, % 9, % 8, % 54, % Non-microscopic confirmed 1, % 1, % 1, % 1, % 1, % 5, % Unknown % % % % % 3, % Type of reporting source Hospital inpatient/outpatient or clinic 12, % 10, % 9, % 8, % 7, % 49, % Rad treatment/medical oncology center % % % % % 2, % Laboratory only (hospital or private) % % % % % 3, % Physicians off/private med practitioner 1, % % % % % 4, % Nursing/convalescent home/hospice % % % % % % Other hospital outpatient/surgery center % % % % % 3, % Urban/Rural 2013 Metro 12, % 11, % 10, % 10, % 10, % 52, % Non-Metro 2, % 2, % 2, % 2, % 2, % 10, % Unknown % % % % % % 5
6 Figure 2. Percentage of unknown PR status among female invasive breast cancer by registry, % 25.0% 20.0% 15.0% 10.0% US average 5.8% 5.0% 0.0% US Registry ID 6
7 TablTable 3. Unknown CS SSF15 (HER2) status among female invasive breast cancer, February 9, Registry Level total 11.9% 10.5% 9.1% 8.7% 10.0% 25-75% Percentile (IQR) 7.4%-11.9% % 5.6%-9.0% 5.4%-8.5% 6.4%-9.5% Minimum 3.7% 4.2% 3.6% 2.7% 4.6% Median 9.1% 7.7% 6.8% 6.6% 7.8% Maximum 27.3% 25.7% 21.6% 19.9% 23.5% Upper Whisker 18.7% 18.0% 14.1% 13.2% 14.2% # outside of upper whisker All cases combined Race White 21, % 18, % 16, % 16, % 72, % Black 3, % 2, % 2, % 2, % 11, % AI/AN % % % % % Asian or Pacific Islander % % % % 3, % Unknown race % % % % 1, % Age years 4, % 3, % 3, % 3, % 14, % years 8, % 7, % 6, % 6, % 29, % years 5, % 5, % 4, % 4, % 20, % 75+ years 6, % 6, % 5, % 5, % 23, % Dx Confirmation Microscopic confirmed 23, % 21, % 18, % 18, % 81, % Non-microscopic confirmed 1, % 1, % 1, % 1, % 4, % Unknown % % % % 2, % Type of reporting source Hospital inpatient/outpatient or clinic 21, % 18, % 16, % 15, % 72, % Rad treatment/medical oncology center % % % % 3, % Laboratory only (hospital or private) % % % % 3, % Physicians off/private medical practitioner 1, % % % % 3, % Nursing/convalescent home/hospice % % % % % Other hospital outpatient/surgery center 1, % 1, % 1, % 1, % 6, % Urban/Rural 2013 Metro 21, % 19, % 17, % 16, % 74, % Non-Metro 4, % 3, % 3, % 3, % 14, % Unknown % % % % % 7
8 30.0% Figure 3. Percentage of unknown HER2 status among female invasive breast cancer by registry, % 20.0% 15.0% US average 10% 10.0% 5.0% 0.0% US Registry ID Table 8
9 Table 4. Unknown CS SSF1 (ER) status among female breast ductal carcinoma in situ, Registry Level total 15.3% 13.1% 10.9% 9.6% 8.0% 11.3% 25-75% Percentile (IQR) 8.8%-18.0% 7.1%-17.3% 5.9%-14.2% 6.2%-12.2% 4.5%-10.7% 6.7%-14.6% Minimum 3.2% 1.1% 1.2% 2.1% 0.7% 3.8% Median 14.0% 10.2% 8.4% 7.8% 6.4% 9.3% Maximum 31.2% 32.8% 31.3% 27.5% 20.5% 26.9% Upper Whisker 31.8% 32.6% 26.7% 21.2% 20.0% 26.5% # outside of upper whisker All cases combined Race White 5, % 4, % 4, % 3, % 3, % 21, % Black % % % % % 3, % AI/AN % % % % % % Asian or Pacific Islander % % % % % 1, % Age Unknown race % % % % % % years 1, % 1, % 1, % % % 5, % years 2, % 2, % 1, % 1, % 1, % 10, % years 1, % 1, % 1, % 1, % % 6, % 75+ years 1, % % % % % 4, % Dx Confirmation Microscopic confirmed 6, % 6, % 5, % 4, % 3, % 26, % Non-microscopic confirmed % % % % % % Unknown % % Type of reporting source Hospital inpatient/outpatient or clinic 5, % 4, % 4, % 3, % 2, % 21, % Rad treatment/medical oncology center % % % % % 1, % Laboratory only (hospital or private) % % % % % 1, % Physicians off/private medical practitioner % % % % % % Nursing/convalescent home/hospice % % 0 0.0% 0 0.0% % Other hospital outpatient/surgery center % % % % % 2, % Urban/Rural 2013 Metro 5, % 5, % 4, % 3, % 3, % 22, % Non-Metro % % % % % 3, % Unknown % % % % % % 9
10 Figure 4. Percentage of unknown ER status among female DCIS by registry, % 70.0% 65.0% 60.0% 55.0% 50.0% 45.0% 40.0% 35.0% 30.0% 25.0% 20.0% 15.0% 10.0% 5.0% 0.0% US average 11.3% US 10
11 Table 5. Unknown CS SSF2 (PR) status among female breast ductal carcinoma in situ, Registry Level total 19.4% 17.4% 15.1% 13.7% 13.6% 15.8% 25-75% Percentile (IQR) 12.6%-24.0% 10.1%-20.6% 8.7%-18.9% 8.2%-17.0% 6.8%-16.5% 9.4%-18.4% Minimum 3.2% 1.1% 1.7% 3.4% 1.8% 4.0% Median 17.1% 15.5% 14.1% 12.8% 11.1% 14.4% Maximum 71.6% 78.7% 69.8% 69.3% 76.4% 73.0% Upper Whisker 41.1% 36.4% 34.2% 30.2% 31.1% 31.9% # outside of upper whisker All cases combined Race White 7, % 6, % 5, % 5, % 5, % 30, % Black % % % % % 4, % AI/AN % % % % % % Asian or Pacific Islander % % % % % 1, % Unknown race % % % % % % Age years 1, % 1, % 1, % 1, % 1, % 7, % years 3, % 3, % 2, % 2, % 2, % 15, % years 2, % 1, % 1, % 1, % 1, % 8, % 75+ years 1, % 1, % 1, % % % 5, % Dx Confirmation Microscopic confirmed 8, % 8, % 7, % 6, % 6, % 37, % Non-microscopic confirmed % % % % % % Unknown % % Type of reporting source Hospital inpatient/outpatient or clinic 7, % 6, % 5, % 5, % 5, % 30, % Rad treatment/medical oncology center % % % % % 1, % Laboratory only (hospital or private) % % % % % 1, % Physicians off/private medical practitioner % % % % % % Nursing/convalescent home/hospice % % 0 0.0% 0 0.0% % Other hospital outpatient/surgery center % % % % % 3, % Urban/Rural 2013 Metro 7, % 6, % 6, % 5, % 5, % 32, % Non-Metro 1, % 1, % % % % 4, % Unknown % % % % % % 11
12 75.0% 70.0% 65.0% 60.0% 55.0% 50.0% 45.0% 40.0% 35.0% 30.0% 25.0% 20.0% 15.0% 10.0% 5.0% 0.0% Figure 4. Percentage of unknown PR status among female DCIS by registry, US average 15.8% US 12
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