Cancer in North America: Volume One: Combined Cancer Incidence for the United States, Canada, and North America

Transcription

1 Cancer in North America: Volume One: Combined Cancer Incidence for the United States, Canada, and North America Seattle / Puget Sound Greater Bay Area Metro Detroit Washington D.C. Los Angeles Metro Atlanta North American Association of Central Cancer Registries, Inc.

2

3 EXECUTIVE SUMMARY Members of the North American Association of Central Cancer Registries, Inc. (NAACCR) participate voluntarily in an annual call for data to develop a multi-registry, aggregated data resource for cancer surveillance and research. In May 2014, NAACCR released the three volume monograph, Cancer in North America (CINA): This release of cancer incidence statistics for the United States is the 24th publication in the series and the 22 nd release that includes statistics for both Canada and the United States. The monograph is organized into three volumes. Volume One presents the aggregated cancer incidence data representing North America including data from the high quality registries in the United States and Canada. The cancer incidence statistics for the Canadian and United States populations are provided. The combined United States data are presented by race (i.e., white, black, Asian/Pacific Islander, American Indian/Alaska Native) and for Hispanic/Latino ethnicity. Age-adjusted rates are provided standardized to three populations to enable national and international comparisons (2000 US, 1996 Canadian, and the world population standards). Volume One also includes combined pediatric cancer data for age groups 0-19 and US combined cancer stage at diagnosis data for cervix, colorectal, female breast, lung, prostate cancers by age group, race and ethnicity and gender. Volume Two describes the registry-specific cancer incidence rates by cancer site, sex, race, and ethnicity for all NAACCR members in good standing that submit data and elect to be included in the monograph. Volume Three presents the registry-specific cancer death rates by cancer site, sex, race, and ethnicity. All three volumes along with population data, supporting appendices, and cancer rates age-adjusted to the US, Canadian and World population standards are available free of charge from the NAACCR website. This year s publication includes cancer incidence data for 50 states, District of Columbia, Puerto Rico, all 5 SEER urban registries, and 12 Canadian registries. For the second time, CINA includes registry-specific data on stage at diagnosis for female breast, colon and rectum, lung, uterine cervix and prostate cancers for selected U.S and Canadian registries in Volume Two. Note that this publication utilizes population estimates that are based upon the United States 2010 and Canada 2011 censuses. Note also that Volume Three, on cancer mortality, will be published and available soon after 2011 U.S. mortality data become available. In addition to publication of cancer statistics for the most recent five-year period, the CINA data resource is used to create CINA+ Online database and NAACCR FastStats (graphic and tables by cancer sites, race/sex, race/ethnicity, age at diagnosis, sex, registry, and data type) for public queries regarding cancer incidence for the most recent five years. The CINA data is also used to develop a discretionary research data set (CINA Deluxe), including data from 1995 to 2011, to facilitate analytic studies conducted by epidemiologists and other qualified researchers. The data within this report are also available as an electronic reproduction of all cancer statistics reported in the CINA monograph for use in SAS analytic software and a discretionary data set of the data in CINA+ Online (named CINA Plus in SEER*Stat) in SEER*Stat software for approved uses by NAACCR members. These preeminent cancer data resources are unparalleled in geographic scope, timeliness of statistics, and assurance of standardization of information and data quality across all contributors, with standard data quality metrics reported for all contributors. We hope that Cancer in North America: , with the companion CINA products and resources, facilitate studies of cancer burden, so that we are better able to identify and understand appropriate and important measures to control the myriad diseases within the cancer rubric. The cancer surveillance infrastructure in the U.S. and Canada has been orchestrated to meet these objectives. We gratefully acknowledge the voluntary cooperation and recognize the commitment of NAACCR member registries to the achievement of high quality standardized cancer incidence data so that aggregation of information from across the states, provinces, territories, and regions in North America is possible and allows NAACCR to share meaningful information on our regions and countries. The Editors May 2014 EXECUTIVE SUMMARY i

4

5 CANCER IN NORTH AMERICA: VOLUME ONE: COMBINED CANCER INCIDENCE FOR THE UNITED STATES, CANADA AND NORTH AMERICA A Publication of the North American Association of Central Cancer Registries, Inc. (NAACCR) Editors: Glenn Copeland, Michigan Cancer Surveillance Program Andrew Lake, Information Management Services, Inc. Rick Firth, Information Management Services, Inc. Brad Wohler, Florida Cancer Data System Xiao-Cheng Wu, Louisiana Tumor Registry Carol Russell, Alberta Cancer Registry Dianne Zakaria, Statistics Canada Maria J. Schymura, New York State Cancer Registry Jim Hofferkamp, NAACCR, Inc. Recinda Sherman, NAACCR Inc. Betsy Kohler, NAACCR, Inc. May 2014 The Editorial Subcommittee of the NAACCR Standing Committee, Data Use and Research Committee publishes this monograph. We are grateful to the National Cancer Institute, National Institutes of Health (NCI/NIH) for providing support for the production under Contract No. HHSN C/ADB Contract No. PC We acknowledge partial support of NAACCR staff by cooperative agreement U75/CCU from the Centers for Disease Control and Prevention (CDC) and by the NCI/NIH Contract No. HHSN C/ADB Contract No. PC Its contents are solely the responsibility of the editors and do not necessarily represent the official view of CDC. iii

6

7 CINA PARTICIPANTS Seattle Puget Sound Greater Bay Area Metro Detroit Los Angeles Washington D.C. Metro Atlanta Participating Registries SUGGESTED CITATION: Copeland G, Lake A, Firth R, Wohler B, Wu XC, Russell C, Zakaria D, Schymura M, Hofferkamp J, Sherman R, Kohler B (eds). Cancer in North America: Volume One: Combined Cancer Incidence for the United States, Canada and North America. Springfield, IL: North American Association of Central Cancer Registries, Inc. May v

8 TABLE OF CONTENTS SECTION I: Introduction and Technical Notes... I-1 SECTION II: Top Five Most Commonly Diagnosed Cancers in North America Top Five Most Commonly Diagnosed Cancers in North America... II-1 Top Five Most Commonly Diagnosed Cancers in the U.S. by Race/Ethnicity Males... II-2 Females... II-3 SECTION III: Average-annual Age-adjusted NAACCR Combined Cancer Incidence Rates for the United States, Canada and North America Data Quality Indicators for the United States... III-1 Map: Registries included in U.S. Combined Incidence for All Races... III-3 Combined Registries, All Races (2000 U.S. and 1996 Canadian populations)... III-4 Five Most Commonly Diagnosed Cancers, Incidence Rates by Registry, All Races, Males (2000 U.S. population)... III-5 All Races, Males (1996 Canadian population)... III-7 All Races, Females (2000 U.S. population)... III-9 All Races, Females (1996 Canadian population)... III-11 Map: Registries included in U.S. Combined Incidence for White... III-13 Combined Registries, White (2000 U.S. and 1996 Canadian populations)... III-14 Five Most Commonly Diagnosed Cancers, Incidence Rates by Registry, White, Males (2000 U.S. population)... III-15 White, Males (1996 Canadian population)... III-17 White, Females (2000 U.S. population)... III-19 White, Females (1996 Canadian population)... III-21 Map: Registries included in U.S. Combined Incidence for Black... III-23 Combined Registries, Black (2000 U.S. and 1996 Canadian populations)... III-24 Five Most Commonly Diagnosed Cancers, Incidence Rates by Registry, Black, Males (2000 U.S. population)... III-25 Black, Males (1996 Canadian population)... III-27 Black, Females (2000 U.S. population)... III-29 Black, Females (1996 Canadian population)... III-31 Map: Registries included in U.S. Combined Incidence for Asian/Pacific Islander... III-33 Combined Registries, Asian/Pacific Islander (2000 U.S. and 1996 Canadian populations)... III-34 Five Most Commonly Diagnosed Cancers, Incidence Rates by Registry, Asian/Pacific Islander, Males (2000 U.S. population)... III-35 Asian/Pacific Islander, Males (1996 Canadian population)... III-37 Asian/Pacific Islander, Females (2000 U.S. population)... III-39 Asian/Pacific Islander, Females (1996 Canadian population)... III-41 Map: Selected CHSDA Counties included in U.S. Combined Incidence for American Indian/Alaskan Native... III-43 Combined Registries, American Indian/Alaskan Native (2000 U.S. and 1996 Canadian populations)... III-44 Five Most Commonly Diagnosed Cancers, Incidence Rates by Registry, American Indian/Alaskan Native, Males (2000 U.S. population)... III-45 American Indian/Alaskan Native, Males (1996 Canadian population)... III-47 American Indian/Alaskan Native, Females (2000 U.S. population)... III-49 American Indian/Alaskan Native, Females (1996 Canadian population)... III-51 Most Frequent Cancer Sites by IHS Region, American Indian/Alaskan Native, Males (2000 U.S. population)... III-53 American Indian/Alaskan Native, Females (2000 U.S. population)... III-55 Map: Registries included in U.S. Combined Incidence for Hispanic/Latino, All Races... III-57 Combined Registries, Hispanic/Latino, All Races (2000 U.S. and 1996 Canadian populations)... III-58 Commonly Diagnosed Cancers, Incidence Rates by Registry, Hispanic/Latino, All Races, Males (2000 U.S. population)... III-59 Hispanic/Latina, All Races, Females (2000 U.S. population)... III-63 vi TABLE OF CONTENTS

9 Contents Map: Registries included in U.S. Combined Incidence for Non-Hispanic White... III-67 Combined Registries, Non-Hispanic White (2000 U.S. and 1996 Canadian populations)... III-68 Commonly Diagnosed Cancers, Incidence Rates by Registry, Non-Hispanic White, Males (2000 U.S. population)... III-69 Non-Hispanic White, Females (2000 U.S. population)... III-73 Map: Registries included in U.S. Combined Incidence for Non-Hispanic Black... III-77 Combined Registries, Non-Hispanic Black (2000 U.S. and 1996 Canadian populations)... III-78 Commonly Diagnosed Cancers, Incidence Rates by Registry, Non-Hispanic Black, Males (2000 U.S. population)... III-79 Non-Hispanic Black, Females (2000 U.S. population)... III-83 Data Quality Indicators for Canada... III-88 Map: Registries included in Canadian Combined Incidence for All Races... III-89 Combined Registries, All Races (2000 U.S. and 1996 Canadian populations)... III-90 Five Most Commonly Diagnosed Cancers, Incidence Rates by Registry, All Races, Males (2000 U.S. and 1996 Canadian populations)... III-91 All Races, Females (2000 U.S. and 1996 Canadian populations)... III-92 Data Quality Indicators for North America... III-94 Map: Registries included in North America Combined Incidence for All Races... III-95 Combined Registries, All Races (2000 U.S. and 1996 Canadian populations)... III-96 Five Most Commonly Diagnosed Cancers, Incidence Rates by Registry, All Races, Males (2000 U.S. population)... III-97 All Races, Males (1996 Canadian population)... III-99 All Races, Females (2000 U.S. population)... III-101 All Races, Females (1996 Canadian population)... III-103 Map: Registries included in U.S. Pediatric Cancer Incidence... III-106 Age-specific Rates for the United States All Races, Males... III-107 All Races, Females... III-108 White, Males... III-109 White, Females... III-110 Black, Males... III-111 Black, Females... III-112 Asian/Pacific Islander, Males... III-113 Asian/Pacific Islander, Females... III-114 American Indian/Alaskan Native, Males... III-115 American Indian/Alaskan Native, Females... III-116 Hispanic/Latino, All Races, Males... III-117 Hispanic/Latina, All Races, Females... III-118 Non-Hispanic White, Males... III-119 Non-Hispanic White, Females... III-120 Non-Hispanic Black, Males... III-121 Non-Hispanic Black, Females... III-122 Age-adjusted Rates (2000 U.S. and 1996 Canadian population) (Ages 0-14, Ages 0-19) All Races, Males... III-123 All Races, Females... III-124 White, Males... III-125 White, Females... III-126 Black, Males... III-127 Black, Females... III-128 Asian/Pacific Islander, Males... III-129 Asian/Pacific Islander, Females... III-130 American Indian/Alaskan Native, Males... III-131 American Indian/Alaskan Native, Females... III-132 Hispanic/Latino, All Races, Males... III-133 Hispanic/Latina, All Races, Females... III-134 Non-Hispanic White, Males... III-135 Non-Hispanic White, Females... III-136 Non-Hispanic Black, Males... III-137 Non-Hispanic Black, Females... III-138 Map: Registries included in Canadian Pediatric Cancer Incidence... III-140 Age-specific Rates for Canada All Races, Males... III-141 All Races, Females... III-142 TABLE OF CONTENTS vii

10 Contents Age-adjusted Rates (2000 U.S. and 1996 Canadian population) (Ages 0-14, Ages 0-19) All Races, Males... III-143 All Races, Females... III-144 Map: Registries included in North American Pediatric Cancer Incidence... III-146 Age-specific Rates for North America All Races, Males... III-147 All Races, Females... III-148 Age-adjusted Rates (2000 U.S. and 1996 Canadian population) (Ages 0-14, Ages 0-19) All Races, Males... III-149 All Races, Females... III-150 SECTION IV: Stage at Diagnosis by Age for Select Cancer Sites United States Combined Registries... IV-1 Canada Combined Registries... IV-3 North America Combined Registries... IV-4 All Appendices are available on the NAACCR website: viii TABLE OF CONTENTS

11 Section I Introduction and Technical Notes Seattle Puget Sound Greater Bay Area Metro Detroit Los Angeles Washington D.C. Metro Atlanta Participating Registries

12

13 Cancer in North America: INTRODUCTION The North American Association of Central Cancer Registries, Inc. (NAACCR) is a professional organization that develops and promotes uniform data standards for cancer registration; provides education and training; certifies population based registries; aggregates and publishes data from central cancer registries; and promotes the use of cancer surveillance data and systems for cancer control and epidemiologic research, public health programs, and patient care to reduce the burden of cancer in North America. NAACCR annually produces this statistical monograph on cancer in North America to provide cancer incidence and mortality statistics for the United States, Canada, and North America. This year marks the 24th annual release of the series of Cancer in North America (CINA) monographs. The 2014 monograph includes data from 69 central population-based registries: 57 from the United States (50 states, the District of Columbia, Puerto Rico and 5 metropolitan areas) and 12 from Canada (9 provinces and 3 territories). The submitted data reflect 98% population coverage of Canada and the United States. Combined, five-year average annual incidence statistics for the United States, for Canada and for North America are created from registries that met or exceeded the NAACCR standards of fitness for use in aggregated incidence data for all years, The combined statistics presented in Volume One reflect 97% of the U.S. population (47 states and the District of Columbia). Volume One includes statistics from the 10 Canadian registries that met the CINA inclusion requirements, reflecting 38% of the Canadian population. This year Volume One presents the combined U.S. and Canadian statistics for cancer incidence rates across North America. This monograph would not be possible without the commitment by population-based cancer registries throughout the United States and Canada to collect timely, complete, and accurate data. NAACCR issues an annual call for data to member registries to create the CINA monograph and other useful CINA products for data analyses and cancer incidence information (e.g., CINA+ Online, NAACCR FastStats, CINA in SEER*Stat, CINA Plus in SEER*Stat, CINA Monograph data in SAS Data set and CINA Deluxe). An Editorial Board of member volunteers, with support from NAACCR staff and staff from Information Management Services, takes on the responsibility to oversee the call for data, evaluate all submissions, and make all editorial decisions and activities in production of the monograph. Our efforts are to provide timely and useful information on cancer incidence and mortality for all geographic areas and race/ethnic groups in the United States and Canada. The publication includes U.S. cancer incidence and mortality for white, black, Hispanic/Latino and Asian/Pacific Islander as combined and registry specific rates and American Indian and Alaskan Native populations presented for U.S. counties located in Indian Health Service Contract Health Service Delivery Areas (CHSDA) of the United States (excepting only for Kansas). CONTENTS OF THE CINA MONOGRAPH The CINA monograph is comprised of three volumes as described below. Rates are presented as averageannual, age-adjusted rates using three different standard million populations: the 2000 U.S., the 1996 Canadian, and the World standard populations. We believe that presenting cancer rates adjusted to all three standards enhances the meaning and utility of the rates for users in the United States, Canada, and international settings. All volumes of the CINA publication, including sections containing incidence rates standardized to the World Standard, and the population counts used in the calculation of cancer rates are available for download on the NAACCR website, Volume One, Combined Cancer Incidence for the United States, Canada, and North America presents cancer incidence data that have been combined to create five-year, average-annual data for cancers occurring in all persons and for children, aged 0 to 14, and 0 to 19. Registries submitting the data must meet the NAACCR criteria of high quality incidence data indicating that the data are fit for use at the time of data submission. The criteria for the standard are described in detail below in the Data Quality Indicator section. INTRODUCTION AND TECHNICAL NOTES I-1

14 In the United States, cancer counts and incidence rates are presented for all races combined, black, white, Asian/Pacific Islander, American Indian/Alaskan Native populations and for Hispanic/Latino, non-hispanic white, non-hispanic black. Volume One is comprised of three major sections: Section two includes the five most common types of cancer by sex in North America, the United States and Canada based on the combined United States and the combined Canadian data. The section also includes the top five most common types of cancer by sex, race and ethnicity in the United States based on the combined United States data. Section three provides cancer incidence rates for the United States, Canada and North America. The rates for the United States are presented for all races combined, white, black, Asian or Pacific Islander, American Indian/Alaska Native, Hispanic, non-hispanic white and non-hispanic black populations for all ages combined. The rates for Canada and North America are presented for all races combined and for all ages combined. Also included in section three are tables of cancer rates for children, aged 0-14 and 0-19 for the United States, Canada and North America. As with the tables for all ages, the pediatric tables are presented by race and ethnicity for the United States and for all races combined for Canada and North America. Section four contains the frequency counts, percent distribution and age-adjusted rate of cancer by summary stage at diagnosis (derived from the Collaborative Stage system) for female breast, prostate, lung, uterine cervix and colorectal cancers. Combined United States data are provided for white, black, Asian or Pacific Islander, and American Indian/Alaska Native population with American Indian/Alaska Native data limited to Contract Health Service Delivery Areas counties. In addition, combined United States data, combined Canadian data and combined North America data are provided for all races combined. U.S. data are also provided by Hispanic ethnicity. Volume Two, Registry-specific Cancer Incidence in the United States and Canada presents cancer incidence data for NAACCR-member, population-based central cancer registries in Canada and the United States that have agreed to participate in the CINA monograph. Five-year averages of data are presented for the years 2007 to Each set of data tables includes demographic and data quality information and registry descriptions to help interpret the statistics reported. For the second time, the 2014 publication includes registry specific data on stage at diagnosis for female breast, lung, colon and rectum, prostate and uterine cervix cases for all registries submitting stage data for 2007 through In the United States, cancer incidence rates are calculated for the following race/ethnic populations: all races combined, white, black, Asian or Pacific Islander, American Indian/Alaskan Native for CHSDA counties, Hispanic/Latino (all races), non-hispanic white, and non-hispanic black. Race and ethnicity information is not collected in Canada, and thus is not presented. Volume Three, Registry-specific Cancer Mortality in the United States and Canada presents cancer mortality data for all geographic areas of Canada and the United States, including each nation as a whole. SOURCES OF DATA Cancer Incidence. A cancer registry must be population-based and a NAACCR member in good standing to be included in NAACCR data publications. All cancer registries in the United States and Canada are NAACCR members, including the three territories in Canada and three U.S. territories. An annual request is sent to all members to submit voluntarily a data file for use in CINA, CINA research and data information products, the U.S. Annual Report to the Nation, and the American Cancer Society s Cancer Facts and Figures annual publication. All NAACCR member registries receive support from the state, province or territory. In the U.S., they also participate in the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) Program or the Centers for Disease Control and Prevention's National Program of Cancer Registries (NPCR) or both. In Canada, all registries submit data to the Canadian Cancer Registry maintained by Statistics Canada. I-2 INTRODUCTION AND TECHNICAL NOTES

15 Mortality Data. Mortality data for 2007 to 2011 for United States and Puerto Rico were obtained from the National Center for Health Statistics (NCHS) of the Centers for Disease Control and Prevention (CDC), as provided to the National Cancer Institute (NCI). The Canadian mortality data for 2007 to 2011 were obtained from Statistics Canada's Vital Statistics Death Database ( Function=getSurvey&SDDS=3233). Population Estimates. To assist the reader, population estimates by age, sex, and race/ethnicity (where relevant) used in the calculation of rates in the monograph are available for each central registry, the United States and Canada. These data are available online on the NAACCR website at Population estimates for 2007 through 2011 for the United States, individual states, and SEER metropolitan areas were obtained from the SEER program. These estimates were based on United States Census Bureau population estimates for these years and represent a modification of the annual time series population estimates produced by the Population Estimates Program of the Census Bureau with support from the NCI. The population estimates incorporate bridged, single race estimates that are derived from the original multiple race categories in the 2010 Census. These bridged estimates are consistent with the four race groups enumerated in the 1990 Census and were produced under a collaborative arrangement between the National Center for Health Statistics (NCHS) and the Census Bureau. The methodology implemented by the Census Bureau to develop these county estimates is comparable to that used to produce national and state intercensal estimates and is described on the Census Bureau s website (National Center for Health Statistics 2003). In 2007, the U.S. Census revised their methodology for population estimation. This revision impacts all population denominators for 2007 to The main effect of this approach was on specific age groups, particularly, two of the oldest age groups, ages and 75 and older. In many states, the new method results in a larger increase in the younger age category and fewer in the older age category than estimated in previous years. Subsequently, this revision contributed to a larger decrease in age-adjusted cancer mortality rates in some states than what was expected based on statistics from last year. The NCI modifies the Census data for the population estimates for the state of Hawaii. The Epidemiology Program of the Hawaii Cancer Research Center has developed its own set of population estimates, based on sample survey data collected by the Hawaii Department of Health. This effort grew out of a concern that the native Hawaiian population had been vastly undercounted in previous censuses. The Hawaii adjustment to the Census Bureau estimates has the net result of reducing the estimated white population and increasing the Asian and Pacific Islander population for the state. The Census Bureau estimates for the total population, black population, and American Indian and Alaska Native populations in Hawaii are unaffected. Refer to the SEER Cancer Statistics Review, and its methodologies for specific documentation regarding modifications made by the NCI to the Census Bureau estimates (Horner 2009). For Canada, Statistics Canada provided the estimates of the Canadian population for all Canadian provinces and territories, adjusted for census net under coverage ( Lang=eng&id= &pattern=population+estimates&tabMode=dataTable&srchLan=-1&p1=1&p2=-1). CANCER SITE CODING, Incidence Data. All cancer registries use the International Classification of Diseases for Oncology, third edition (ICD-O-3) to code the anatomic site and morphology. Cancer incidence statistics include invasive cancers only, with the exception of in situ cancer of the bladder. Although tables include incidence statistics for breast cancer in situ and benign tumors of the brain and central nervous system, these cases are not included in any counts or rates of total cancer incidence. The SEER program site recode groups were used for classifying types of cancer, using anatomic site and morphology. Using this standard ontology, only squamous and basal cell carcinomas of the lip and genital organs are included in the data reported. All categories used to present pediatric cancer rates in Volume One are based on the International Classification of Childhood Cancer, third edition (ICCC-3) (Steliarova-Foucher 2005). INTRODUCTION AND TECHNICAL NOTES I-3

16 Summary tables of all codes and site groups for incidence can be found in the electronic copy of the CINA Monograph Appendices on the NAACCR website, Mortality Data. Underlying cause of death was coded using the International Classification of Diseases version 10 (ICD-10). Cancer deaths were defined as those coded C00 through C97 in ICD-10. The SEER mortality recode scheme was used to classify cancer deaths into the groupings used in the volume III (see Appendix B on the NAACCR website, Multiple Primary Determination Rules. During 2007 a significant revision was made to the decision rules followed to determine when a multiple primary cancer is present. These new rules may have an effect on the number of subsequent primaries identified with these effects varying by cancer site and type. Preliminary data suggest that overall incidence rates will vary only marginally for most cancer sites. This new rule will affect data for the incidence years within the current publication. For more information on these new rules please see Hispanic/Latino Ethnicity Identification. The ethnicity available in medical records and reported to cancer registries is enhanced by the use of the NAACCR Hispanic Identification Algorithm, version 2 (NHIAv2). NHIAv2 uses a combination of NAACCR variables including direct identification of ethnicity from the Spanish/Hispanic Origin variable (NAACCR data element 190 values 1-6), and information indirectly derived based on an evaluation of the strength of the birthplace, race, and surname (including maiden name when available) associations with Hispanic ethnicity status. After applying NHIAv2, cases not ultimately classified as Hispanic are classified as non-hispanic, leaving no cases with unknown Hispanic status. The NHIAv2 algorithm allows the user to run the program using one of three possible options: 1) All Records: Surname portion is run on 0 (non-hispanic), 7 (surname only), and 9 (unknown) for all counties. After the algorithm, item 190 codes (0, 7, 9 ) are either NHIA - Hispanic or non-hispanic. 2) Option 1: (The default) For counties with 5% or more Hispanics - as for all records option. For counties with < than 5% Hispanic, surname portion is run on 7 (surname only) and 9 (unknown). After the algorithm, item 190 codes (7, 9 ) are either NHIA - Hispanic or non-hispanic. 3) Option 2: For counties with 5% or more Hispanics - as for all records option. For counties with < than 5% Hispanic, surname portion is run on 7 (surname only). These become either NHIA - Hispanic or non-hispanic. All cases coded to 9 on item 190 are converted to NHIA - non-hispanic. A comparison of the direct and indirect categorization of Hispanic ethnicity is provided in the Appendix F available from the NAACCR Website, The NHIAv2 method is described in detail elsewhere. (NAACCR Race and Ethnicity Work Group, 2011; NAACCR Guideline for Enhancing Hispanic-Latino Identification: Revised NAACCR Hispanic/Latino Identification Algorithm [NHIA v2.2.1], Revised September 12, 2011.) [URL: Last Accessed, April 23, 2014] Asian/Pacific Islander Identification. The information on Asian and Pacific Islander populations is also enhanced by submitting registries using a NAACCR developed algorithm (NAACCR, 2010). The NAACCR Asian Pacific Islander Identification Algorithm version 1 (NAPIIA v1.2.1) uses a combination of NAACCR variables to classify cases directly or indirectly as Asian/Pacific Islander for analytic purposes. It is focused on coding cases with a race code of Asian NOS (race code 96) or Pacific Islander NOS (race code 97) to a more specific Asian or Pacific Islander race category, using the birthplace and name fields (first, last, and maiden names). Birthplace can be used to indirectly assign a specific race to one of eight Asian groups (Chinese, Japanese, Vietnamese, Korean, Asian Indian, Filipino, Thai, and Cambodian) and three Pacific Islander groups (Samoan, Micronesian, and Polynesian). Names can be used to indirectly assign a specific race to one of seven Asian groups (Chinese, Japanese, Vietnamese, Korean, Asian Indian, Filipino, and Hmong) and three Pacific Islander groups (Hawaiian, Guamanian, and Samoan). The algorithm uses the following NAACCR standard I-4 INTRODUCTION AND TECHNICAL NOTES

17 variables: Race 1 through Race 5 (NAACCR Items 160 through 164), Name Last (NAACCR Item 2230), Name First (NAACCR Item 2240), Name Maiden (NAACCR Item 2390), Birthplace (NAACCR Item 250), Sex (NAACCR Item 220). Misclassification of American Indian and Alaskan Native Populations. The collection of accurate information on the cancer incidence in American Indian and Alaskan Native populations is hampered by misclassification of this population within cancer case reports. In order to address this problem, cancer registries in the United States coordinate with the Centers for Disease Control and the Bureau of Indian Affairs to link their case files to the enrollment files of the Indian Health Service (Espey, et al., 2008). This process identifies significant numbers of American Indians and Alaskan Natives that were otherwise classified within the cancer case report. The improved information on this population enables calculation of much more accurate cancer incidence rates. As presented in the incidence volumes, the data on American Indians and Alaskan natives are restricted to those counties where Indian Health Service Clinics are located, namely Contract Health Service Delivery Area (CHSDA) counties. This restriction assures that the incidence data presented is the best available data for this population. DATA QUALITY INDICATORS NAACCR assesses the quality of cancer incidence data from individual registries for a number of data quality indicators, which are described in detail below. Results for these indicators can be found in the Cancer in North America, Appendices on the NAACCR website. A dash in the tables indicates that data were not submitted for the year or were not able to be calculated. In order to be included in the NAACCR Combined rates presented in Volume One, the data had to meet the criteria for high quality incidence data. These criteria were applied to each year of data individually, except for the estimate of duplicate reports, which was calculated for the years 2007 to 2011 as a whole. _ Data for 2007 through 2011 had to be submitted to NAACCR by December 2, _ The estimate of duplicate case reports had to be less than 2 duplicate reports per 1000 cases. _ All cases had to pass the edits on variables needed to compute cancer incidence rates by site, sex, race, and tumor descriptions on the NAACCR Call for Data EDITS metafile. _ Fewer than 3% of cases had missing information for sex, county of residence at diagnosis, and age at diagnosis, and fewer than 5% of the cases had an unknown race. _ Death clearance must be completed for 2007 through 2011 mortality with the percent of all cases derived from death certificates only (DCOs) of less than 5%. _ The NAACCR method to estimate completeness of case ascertainment yielded an estimate of 90% or higher. _ All cases had to pass the inter-record edits on cases reporting multiple primary cancers, as determined by the standard Inter-record EDITS program developed for the NAACCR Call for Data submissions. Duplicate Case Records. Most central cancer registries rely on multiple reporting sources for cancer case reports. At the central cancer registry, multiple reports for the same patient must then be matched and the information from all records consolidated. In addition to determining whether multiple reports refer to the same individual, central cancer registry staff must also determine whether the tumor represents a new primary tumor or a duplicate report for a tumor already recorded. Failure to eliminate duplicate cases and duplicate tumors results in over-counting cancer cases. As a part of routine cancer registry operations, a variety of tools are used to ensure accurate case linkage and case consolidation. As part of the preparation of the data submission to NAACCR, each registry uses the NAACCR protocol to determine the adequacy of case linkage and consolidation operations in identifying duplicate records. The NAACCR protocol for assessing duplicate cases can be found on the NAACCR website, Completeness of Case Ascertainment. In order to evaluate case completeness for all geographic areas included in this monograph, the NAACCR Method to Estimate Completeness is used. The method is described in detail elsewhere (Wu, et al., 2002; Howe, 2007). A data analysis tool is available on the NAACCR website, INTRODUCTION AND TECHNICAL NOTES I-5

18 that documents and calculates sex-, race-, and sitespecific estimates based on observed incidence counts and rates, observed local cancer death rates, and a standard rate ratio of incidence to mortality. In addition, adjustments are made to the calculations to account for some variation in sex-, race- and site-specific variation in case fatality. The method assumes that the relationship between incidence rates and mortality rates are stable. However, with the recent annual decreases in cancer death rates, and the awareness that the decreases are not the same in all parts of the United States and Canada, it appears that this assumption is being challenged with a noticeable bias in an upward migration of completeness estimates for many locales. The completeness estimates provided in this publication used mortality data for the years to determine completeness in U.S. registries and for for Canadian registries. The percent completeness presented for each registry and used to determine inclusion of individual registry data in the combined rates presented in Volume One were based upon rate ratios of SEER 11 incidence rates divided by U.S. mortality rates. Missing Case Information. NAACCR has developed standards for completeness of data on key data items that are needed to produce meaningful cancer incidence statistics. These key data items include race, sex, county of residence at diagnosis, and age at diagnosis. Cases with unknown sex or age are omitted from all calculations. Cases with unknown race and county of residence were included in the cancer counts and rates for all races and/or all counties combined. Death Certificate Only Cases. The proportion of cases identified by death certificate only (DCO) is an indicator of data quality and completeness. Central cancer registries use death certificates to identify potentially missed cases and to conduct follow back on cases that have cancer on the death certificate but who are not incident cases in the registry. Cases without follow back information are considered to be DCO cases and may have incomplete or missing information, including date of diagnosis and stage at diagnosis. For DCO cases, the date of death is used as the date of diagnosis. Registries that did not use death certificates as a source of case ascertainment have na listed in the death certificate only row on the registry description page. Data Reliability and Accuracy. All data submitted to NAACCR are evaluated for reliability and accuracy using the EDITS program and a specific set of edits incorporated into a Call for Data Edits Metafile. An edit reviews the internal consistency between and among data elements, such as anatomic site and morphology. Cases that are identified as having errors are reviewed by registry staff and resolved prior to their NAACCR submission. The NAACCR Call for Data EDITS metafile is available on the NAACCR website. [URL Last accessed April 23, 2014]. An inter-record edits program, developed by the Centers for Disease Control and Prevention, is used to identify errors among the records reported for persons who have had multiple tumors diagnosed. For example, an inter-record edit will identify whether birthplace is the same on all reports of multiple tumors that are reported for one individual. Timeliness of Data. The NAACCR standard defines timely data as data that are available for use in incidence statistics within 23 months of the close of a diagnostic year (i.e., December 2, 2013 for all cases diagnosed in 2011). Site-Specific Microscopic Confirmation. This criterion is not used by NAACCR to determine high quality for the purposes of this publication. However, it is a useful indicator of quality of data collection. A proportion of microscopically confirmed cases that is too high or low may suggest problems in case ascertainment or abstracting. However, this proportion varies by cancer site. For sites that are more likely to rely on a clinical or radiological diagnosis, e.g., cancers of the pancreas and brain, confirmation rates that are too high may suggest that some clinically diagnosed cases are missing. Also, registries that do not use death certificates for case finding have an artificially high proportion of microscopically confirmed cases, because DCO cases by definition do not have information on whether the tumor was microscopically confirmed. While no NAACCR standard has been determined for microscopic confirmation, the guideline we use is that the proportion should fall between 92 and 96 percent of all cancer cases, based on the experience of the SEER program. I-6 INTRODUCTION AND TECHNICAL NOTES

19 CALCULATION OF STATISTICS Rates. Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age (Ries, et al. 2005), the 1996 Canadian population standard (Statistics Canada, 2003), and to the World population standard (Parkin, et al., 2002). Rates for children and adolescents in Volume One were expressed per million population. The incidence and death rates in this monograph are annual averages for the period 2007 through The age distributions of the three population standards are as follows: AGE GROUP 2000 U.S CDN. WORLD 00 years 3,794,901 12,342 24, years 15,191,619 53,893 96, years 19,919,840 67, , years 20,056,779 67,716 90, years 19,819,518 67,841 90, years 18,257,225 67,761 80, years 17,722,067 72,914 80, years 19,511,370 87,030 60, years 22,179,956 88,510 60, years 22,479,229 80,055 60, years 19,805,793 71,847 60, years 17,224,359 55,812 50, years 13,307,234 44,869 40, years 10,654,272 40,705 40, years 9,409,940 37,858 30, years 8,725,574 32,589 20, years 7,414,559 23,232 10, years 4,900,234 15,424 5, years 4,259,173 11,617 5,000 Total 274,633,642 1,000,000 1,000,000 Standard Errors. Standard errors (S.E.) of the rates were calculated using the formula: w j n S.E. = 2 p where w j = the fraction of the standard population in age group j, n j = number of cases or deaths in that age group, and p j = person years denominator (Breslow and Day, 1987). For many registries, the standard errors of the rates are small, as the population covered is large. However, for registries that cover a small population, the standard error may be substantial. Confidence Intervals. Although not reproduced in the printed monograph, bar charts of the registry-specific, age-adjusted rates with 95 percent confidence intervals (Tiwari, et al., 2006) are available on the NAACCR website ( The confidence intervals allow the user to assess the precision of the estimate and is an approximate and conservative indicator of whether a registry s rate is statistically higher or lower than the rate for the combined United States, based on whether or not the upper or lower limit of the confidence interval overlaps the 95% confidence interval for the United States. 2 j j INTRODUCTION AND TECHNICAL NOTES I-7

20 Comparison of Rates. In addition to true regional variation in cancer risk, differences in cancer incidence or mortality rates between areas may be due to either differences in the demographic makeup of the population or differences in data quality. In making valid comparisons of cancer incidence rates among registries, it is important to review the data quality indicators for each registry and consider differences in the racial composition of the populations being compared before conclusions are drawn about variations in regional rates. Interpretation without consideration of these factors may contribute to misleading or inaccurate conclusions. The standard error of adjusted rates can be used to evaluate the statistical significance of rate differences among comparable populations. For example, if the adjusted rates in two populations are R 1 and R 2 and their standard errors are S.E. 1 and S.E. 2, an approximate confidence interval for the rate ratio can be calculated using the following formula: (R 1 /R 2 ) 1 ± z/x 2 where x = (R B R 2 ) / S E 1 S. E. 2 and z = 1.96 for 95% limits (Parkin, et al., 1992). If this interval does not include one, the two rates are statistically significantly different at a p value of This test can be inaccurate for rates based on fewer than 16 cases or deaths, and it should not be used for rates based on fewer than six cases or deaths. It should be emphasized that this kind of comparison of adjusted rates must be undertaken with caution as misleading conclusions may be drawn if the ratios of the age specific rates in the two populations are not constant in all age groups. In these circumstances, the ratios of the adjusted rates will vary according to the standard populations used (Esteve, et al., 1994). Cell Suppression. Counts and rates were suppressed (indicated by - ) in the tables if the race, gender, and site-specific number of cases or deaths was less than six. Complimentary cell suppression was employed, when necessary, to prevent the contents of a single suppressed cell from being calculated. These counts are included in the calculation of all sites combined. A dash is also used to indicate not applicable, as in the gender specific cancers. If the rate was less than 0.05 per 100,000 then the rate is listed as 0.0. REFERENCES Anderson RN, Minino AM, Hoyert DL, Rosenberg HM. Comparability of cause of death between ICD-9 and ICD-10: Preliminary estimates. National Vital Statistics Reports 2001;49:1-32. Breslow NE and Day NE. Statistical Methods in Cancer Research. Vol. II International Agency for Research on Cancer: Lyon, France. Espey DK, Wiggins CL, Jim MA, Miller BA, Johnson CJ, Becker TM. Methods for improving cancer surveillance data in American Indian and Alaska Native populations. Cancer Sep 1;113(5 Suppl): Espey DK, Wu XC, Swan J, Wiggins C, Jim MA, Ward E, Wingo PA, Howe HL, Ries LA, Miller BA, Jemal A, Ahmed F, Cobb N, Kaur JS, Edwards BK. Annual report to the nation on the status of cancer, , featuring cancer in American Indians and Alaska Natives. Cancer Nov 15;110(10): Esteve J, Benhamou E, and Raymond L. Statistical Methods in Cancer Research. Vol. V International Agency for Research on Cancer: Lyon, France. Horner MJ, Ries LAG, Krapcho M, Neyman N, Aminou R, Howlader N, Altekruse SF, Feuer EJ, Huang L, Mariotto A, Miller BA, Lewis DR, Eisner MP, Stinchcomb DG, Edwards BK (eds). SEER Cancer Statistics Review, , National Cancer Institute. Bethesda, MD [URL: based on November 2008 SEER data submission, posted to the SEER web site, 2009.] I-8 INTRODUCTION AND TECHNICAL NOTES

21 Howe HL, Carozza S, O Malley C, Dolecek TA, Finch JL, Kohler B, Wet D, Liu L, Schymura MJ, Williams M, Abe T, Agovino P, Chen VW, Firth R, Harkins D, Hotes, J, Lake A, Roney D, Suarez L (eds). Cancer in U.S. Hispanics/Latinos, Springfield (IL): North American Association of Central Cancer Registries, December Johnson CH, Peace S, Adamo P, Fritz A, Percy-Laurry A, Edwards BK. The 2007 Multiple Primary and Histology Coding Rules. National Cancer Institute, Surveillance, Epidemiology and End Results Program. Bethesda, MD, NAACCR Expert Panel in Hispanic Identification. Report of the NAACCR Expert Panel on Hispanic Identification Springfield (IL): North American Association of Central Cancer Registries, October NAACCR Latino Research Work Group. NAACCR Guideline for Enhancing Hispanic/Latino Identification: Revised NAACCR Hispanic/Latino Identification Algorithm [NHIA v2]. Springfield (IL): North American Association of Central Cancer Registries. September [URL: Last accessed April 23, 2014]. NAACCR Method to Estimate Completeness. A Data Analysis Tool for Calculations. [URL: Last accessed April 23, 2014]. NAACCR Race and Ethnicity Work Group. NAACCR Asian Pacific Islander Identification Algorithm [NAPIIA v1.2.1]. Springfield, IL: North American Association of Central Cancer Registries, September National Center for Health Statistics. U.S. Census Populations with Bridged Race Categories. September [URL: Last Accessed, April 23, 2014]. Parkin D.M., Whelan S.L., Ferlay J., Teppo L., Thomas D., Thomas D.B. Cancer Incidence in Five Continents. Vol. VIII International Agency for Research on Cancer: Lyon, France. SEER U.S. Standard Population vs. Standard Million. 13 December Steliarova-Foucher E, Stiller C, Lacour B, Kaatsch P. International Classification of Childhood Cancer, third edition. Cancer 2005;103: Tiwari RC, Clegg LX, Zou Z. Efficient interval estimation for age-adjusted cancer rates. Stat Methods Med Res 2006;15: Wu XC, Hotes J, Fulton JP, Cormier M, Correa C, McLaughlin CC, Kosary C, Howe HL, Chen VW (Eds.) Cancer in North America, , Volume One: Introduction and Technical Notes, Incidence. April [URL: Last accessed April 23, 2014]. INTRODUCTION AND TECHNICAL NOTES I-9

22

23 Section II Top Five Most Commonly Diagnosed Cancers in North America Seattle Puget Sound Greater Bay Area Metro Detroit Los Angeles Washington D.C. Metro Atlanta Participating Registries

24

25 Top Five Most Commonly Diagnosed Cancers 1 in North America by Sex, All Races Males/All Races United States Canada North America Cancer Sites Count Percent Cancer Sites Count Percent Cancer Sites Count Percent All Sites 3,837, All Sites 168, All Sites 4,006, Prostate 1,058, Prostate 45, Prostate 1,103, Lung & Bronchus 549, Colon & Rectum 22, Lung & Bronchus 571, Colon & Rectum 352, Lung & Bronchus 22, Colon & Rectum 375, Bladder 247, Bladder 11, Bladder 259, Melanomas of the Skin Non-Hodgkin Lymphoma 7, Melanomas of the Skin 184, Females/All Races United States Canada North America Cancer Sites Count Percent Cancer Sites Count Percent Cancer Sites Count Percent All Sites 3,588, All Sites 151, All Sites 3,740, Breast 1,043, Breast 43, Breast 1,086, Lung & Bronchus 477, Lung & Bronchus 20, Lung & Bronchus 497, Colon & Rectum 333, Colon & Rectum 18, Colon & Rectum 351, Uterus Corpus & Uterus NOS 218, Thyroid 151, Uterus Corpus & Uterus NOS Non-Hodgkin Lymphoma 9, Uterus Corpus & Uterus NOS 227, , Thyroid 156, Compiled by the North American Association of Central Cancer Registries, based on cases included in the combined incidence for North America. TOP 5 CANCERS Combined Incidence II-1

26 Top Five Most Commonly Diagnosed Cancers 1 in the U.S. by Race/Ethnicity, Males Hispanic/Latino, All Races White Black Cancer Sites Count Percent Cancer Sites Count Percent Cancer Sites Count Percent All Sites 253, All Sites 3,236, All Sites 414, Prostate 67, Prostate 839, Prostate 153, Colon & Rectum 26, Lung & Bronchus 471, Lung & Bronchus 60, Lung & Bronchus 22, Colon & Rectum 294, Colon & Rectum 40, Kidney & Renal Pelvis 13, Bladder 227, Kidney & Renal Pelvis 17, Non-Hodgkin Lymphoma 13, Melanomas of the Skin 169, Non-Hodgkin Lymphoma 12, American Indian/Alaskan Native 2 Chinese Japanese Cancer Sites Count Percent Cancer Sites Count Percent Cancer Sites Count Percent All Sites 12, All Sites 19, All Sites 8, Prostate 2, Prostate 3, Prostate 2, Lung & Bronchus 1, Lung & Bronchus 3, Colon & Rectum 1, Colon & Rectum 1, Colon & Rectum 2, Lung & Bronchus 1, Kidney & Renal Pelvis Liver & Intrahepatic Bile Duct Liver & Intrahepatic Bile Duct 1, Bladder Stomach 1, Stomach Filipino Vietnamese Korean Cancer Sites Count Percent Cancer Sites Count Percent Cancer Sites Count Percent All Sites 15, All Sites 8, All Sites 6, Prostate 4, Lung & Bronchus 1, Prostate 1, Lung & Bronchus 2, Liver & Intrahepatic Bile Duct 1, Colon & Rectum Colon & Rectum 1, Prostate 1, Lung & Bronchus Non-Hodgkin Lymphoma Liver & Intrahepatic Bile Duct Colon & Rectum 1, Stomach Non-Hodgkin Lymphoma Liver & Intrahepatic Bile Duct Compiled by the North American Association of Central Cancer Registries, based on cases included in the combined incidence for the United States. 2 Counts and percentages are based upon cancer cases diagnosed among the AI/AN population in CHSDA counties. Statistics exclude data for KS for all years. See Introduction for more information. TOP 5 CANCERS II-2 Combined Incidence

27 Top Five Most Commonly Diagnosed Cancers 1 in the U.S. by Race/Ethnicity, Females Hispanic/Latino, All Races White Black Cancer Sites Count Percent Cancer Sites Count Percent Cancer Sites Count Percent All Sites 261, All Sites 3,038, All Sites 380, Breast 74, Breast 876, Breast 117, Colon & Rectum 22, Lung & Bronchus 416, Lung & Bronchus 46, Thyroid 17, Colon & Rectum 275, Colon & Rectum 41, Lung and Bronchus 17, Uterus Corpus & Uterus NOS Uterus Corpus & Uterus NOS 185, Uterus Corpus & Uterus NOS 22, , Thyroid 127, Pancreas 12, American Indian/Alaskan Native 2 Chinese Japanese Cancer Sites Count Percent Cancer Sites Count Percent Cancer Sites Count Percent All Sites 13, All Sites 20, All Sites 11, Breast 3, Breast 6, Breast 3, Lung & Bronchus 1, Colon & Rectum 2, Colon & Rectum 1, Colon & Rectum 1, Lung & Bronchus 2, Lung & Bronchus 1, Uterus Corpus & Uterus NOS Kidney & Renal Pelvis Thyroid 1, Uterus Corpus & Uterus NOS Uterus Corpus & Uterus NOS , Pancreas Filipino Vietnamese Korean Cancer Sites Count Percent Cancer Sites Count Percent Cancer Sites Count Percent All Sites 20, All Sites 7, All Sites 8, Breast 7, Breast 1, Breast 2, Colon & Rectum 1, Colon & Rectum Colon & Rectum 1, Lung & Bronchus 1, Lung & Bronchus Lung & Bronchus Thyroid 1, Thyroid Thyroid Uterus Corpus & Uterus NOS 1, Liver & Intrahepatic Bile Duct Stomach Compiled by the North American Association of Central Cancer Registries, based on cases included in the combined incidence for the United States. 2 Counts and percentages are based upon cancer cases diagnosed among the AI/AN population in CHSDA counties. Statistics exclude data for KS for all years. See Introduction for more information. TOP 5 CANCERS Combined Incidence II-3

28

29 Section III Average-annual Age-adjusted NAACCR Combined Cancer Incidence Rates for the United States, Canada and North America Seattle Puget Sound Greater Bay Area Metro Detroit Los Angeles Washington D.C. Metro Atlanta Participating Registries

30 COMBINED CANCER INCIDENCE RATES UNITED STATES Race-Specific Population Counts by Year 1 Race All Races 290,574, ,318, ,908, ,388, ,581,907 White 232,239, ,751, ,131, ,453, ,635,690 Black 39,481,273 40,051,840 40,614,067 41,160,645 41,641,076 American Indian/Alaskan Native (AI/AN) 3,684,163 3,833,342 3,987,480 4,118,597 4,177,406 Asian/Pacific Islander (API) 15,168,943 15,682,158 16,175,889 16,656,530 17,127,735 All Races Population : 1,478,772,751 Distribution of Population by Race Black 13.7% AI/AN 1.3% White 79.5% API 5.5% Hispanic/Latino Population Counts by Year 1 Ethnicity Hispanic/Latino, All Races 45,155,607 46,703,646 48,198,087 49,585,787 50,692,432 Non-Hispanic White 191,296, ,564, ,764, ,979, ,193,137 Non-Hispanic Black 37,253,536 37,696,185 38,130,018 38,556,702 38,957,829 Hispanic/Latino Population, Census 2010: 49,324,785 Distribution of Hispanic/Latino Populations 2 Central Amer. 7.9% Dom. Rep. 2.9% South Amer. 5.5% Other 8.1% % Hispanic/Latino of Total Population By Census Year Cuban 3.6% Puerto Rican 9.3% 1 Source: NCI SEER Program, U.S. Population Data 2 Source: U.S. Census Bureau, 2010 Census Mexican 62.7% Census Year UNITED STATES III-1 Combined Incidence

31 Race-Specific Population Indicators ( ) Combined Population: All Races White Black American Indian/Alaskan Native Asian/Pacific Islander 1,478,772,751 1,175,211, ,948,901 19,800,988 80,811,255 COMBINED CANCER INCIDENCE RATES UNITED STATES Percentage of U.S. Population Reflected in the Combined Cancer Statistics: All Races White Black American Indian/Alaskan Native Asian/Pacific Islander 96.5% 96.2% 97.6% 96.3% 97.0% Hispanic/All Races Non-Hispanic White Non-Hispanic Black 240,335, ,798, ,594,270 Number of Cases in Combined Cancer Statistics: All Races 7,426,401 White 6,274,929 Black 795,029 American Indian/Alaskan Native 35,804 Asian/Pacific Islander 201,056 Hispanic/All Races Non-Hispanic White Non-Hispanic Black 97.7% 95.9% 97.5% Hispanic/All Races Non-Hispanic White Non-Hispanic Black 514,516 5,794, ,015 Data Quality Indicators ( ) Indicators (%) Missing Race Missing Sex Missing County Missing Age Death Certificate Only Cases Site-Specific Microscopic Confirmation ( ) Cancer Site % Micro. Confirm Cancer Site % Micro. Confirm All Sites 93.2 Prostate 97.0 Oral Cavity & Pharynx 97.5 Testis 99.0 Esophagus 94.5 Bladder (incl. in situ) 97.8 Stomach 95.9 Kidney & Renal Pelvis 89.9 Colon & Rectum 96.3 Brain & Other Nervous System 84.5 Liver 64.7 Thyroid Gland 99.3 Pancreas 79.7 Hodgkin Lymphoma 98.4 Lung & Bronchus 88.0 Non-Hodgkin Lymphoma 96.3 Melanomas of the Skin 99.0 Multiple Myeloma 87.8 Female Breast (excl. in situ) 98.2 Leukemias 88.0 Cervix uteri 97.3 Brain & ONS 1 benign/borderline 47.5 Uterus Corpus & Uterus NOS Breast in situ Ovary Abbreviations: NOS - Not Otherwise Specified; ONS - Other Nervous System UNITED STATES Combined Incidence III-2

32 NAACCR U.S. Combined Incidence , All Races Combined Seattle Puget Sound Greater Bay Area Metro Detroit Los Angeles Washington D.C. Metro Atlanta Participating Registries UNITED STATES III-3 Combined Incidence All Races

33 Total Cancer Cases and Average Annual Age-adjusted Cancer Incidence Rates* NAACCR United States Combined, , All Races MALES (ALL RACES) FEMALES (ALL RACES) SITES Count Adj. Rate 2000 U.S. S.E. Adj. Rate 1996 Cdn S.E. Count Adj. Rate 2000 U.S. S.E. Adj. Rate 1996 Cdn S.E. All Sites (invasive & in situ bladder) 3,837, ,588, Oral Cavity & Pharynx 127, , Lip 6, , Tongue 37, , Major salivary gland 11, , Floor of mouth 6, , Gum & other mouth 13, , Nasopharynx 6, , Oropharynx 6, , Hypopharynx 8, , Digestive System 717, , Esophagus 61, , Stomach 65, , Small intestine 18, , Colon excl. rectum 242, , Rectum & rectosigmoid 110, , Anus, anal canal & anorectum 10, , Liver 78, , Gallbladder 5, , Pancreas 97, , Respiratory System 606, , Larynx 48, , Lung & bronchus 549, , Bones & Joints 7, , Soft Tissue (incl. heart) 27, , Skin (excl. basal & sq.) 193, , Melanomas of the skin 178, , Breast (excl. in situ) 9, ,043, Female Genital System , Cervix uteri , Uterus Corpus , Uterus, NOS , Ovary , Male Genital System 1,104, Prostate 1,058, Testis 39, Penis 5, Urinary System 413, , Bladder (incl. in situ) 247, , Kidney & renal pelvis 156, , Ureter 5, , Eye & Orbit 6, , Brain & Other Nervous System 56, , Brain 53, , Endocrine System 54, , Thyroid gland 48, , Lymphomas 186, , Hodgkin Lymphoma 22, , Non-Hodgkin Lymphoma 163, , Multiple Myeloma 52, , Leukemias 114, , Acute lymphocytic 13, , Chronic lymphocytic 40, , Acute myeloid 31, , Chronic myeloid 14, , Other leukemias 15, , Mesothelioma 12, , Kaposi Sarcoma 5, Ill-defined & Unknown 140, , Selected tumors (non-invasive) Brain & ONS 1 (benign/borderline) 55, , Breast (in situ) 1, , * Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age and to the 1996 Canadian population standard. - Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. 1 Abbreviations: NOS - Not Otherwise Specified; ONS - Other Nervous System UNITED STATES Combined Incidence All Races III-4

34 UNITED STATES III-5 Combined Incidence All Races Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , All Races, Males All Sites Prostate Lung & Bronchus Colon & Rectum Bladder Melanoma of the Skin Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 3,837, ,058, , , , , Alabama 67, , , , , , Alaska 6, , Arizona 68, , , , , , California 404, , , , , , CA: Greater Bay Area 80, , , , , , CA: Los Angeles 97, , , , , , Colorado 54, , , , , , Connecticut 51, , , , , , Delaware 13, , , , District of Columbia 7, , Florida 284, , , , , , Georgia 113, , , , , , GA: Metropolitan Atlanta 33, , , , , , Hawaii 17, , , , Idaho 19, , , , , , Illinois 166, , , , , , Indiana 80, , , , , , Iowa 44, , , , , , Kansas 38, , , , , , Kentucky 64, , , , , , Louisiana 63, , , , , , Maine 21, , , , , Maryland 70, , , , , , Massachusetts 91, , , , , , Michigan 142, , , , , , MI: Metropolitan Detroit 59, , , , , , Mississippi 41, , , , , , Missouri 78, , , , , , Montana 14, , , , ,

35 UNITED STATES Combined Incidence All Races III-6 Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , All Races, Males All Sites Prostate Lung & Bronchus Colon & Rectum Bladder Melanoma of the Skin Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Nebraska 23, , , , , New Hampshire 19, , , , , , New Jersey 123, , , , , , New Mexico 23, , , , , , New York 271, , , , , , North Carolina 126, , , , , , North Dakota 9, , , , Ohio 155, , , , , , Oklahoma 49, , , , , , Oregon 50, , , , , , Pennsylvania 196, , , , , , Rhode Island 14, , , , , South Carolina 62, , , , , , South Dakota 10, , , , Tennessee 87, , , , , , Texas 256, , , , , , Utah 24, , , , , , Vermont 9, , , Virginia 94, , , , , , Washington 85, , , , , , WA: Seattle/Puget Sound 61, , , , , , West Virginia 29, , , , , , Wisconsin 77, , , , , , Wyoming 6, , Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: S.E. - Standard Error

36 UNITED STATES III-7 Combined Incidence All Races Total Cancer Cases and Average Annual Age-adjusted (1996 Canadian Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , All Races, Males All Sites Prostate Lung & Bronchus Colon & Rectum Bladder Melanoma of the Skin Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 3,837, ,058, , , , , Alabama 67, , , , , , Alaska 6, , Arizona 68, , , , , , California 404, , , , , , CA: Greater Bay Area 80, , , , , , CA: Los Angeles 97, , , , , , Colorado 54, , , , , , Connecticut 51, , , , , , Delaware 13, , , , District of Columbia 7, , Florida 284, , , , , , Georgia 113, , , , , , GA: Metropolitan Atlanta 33, , , , , , Hawaii 17, , , , Idaho 19, , , , , , Illinois 166, , , , , , Indiana 80, , , , , , Iowa 44, , , , , , Kansas 38, , , , , , Kentucky 64, , , , , , Louisiana 63, , , , , , Maine 21, , , , , Maryland 70, , , , , , Massachusetts 91, , , , , , Michigan 142, , , , , , MI: Metropolitan Detroit 59, , , , , , Mississippi 41, , , , , , Missouri 78, , , , , , Montana 14, , , , ,

37 UNITED STATES Combined Incidence All Races III-8 Total Cancer Cases and Average Annual Age-adjusted (1996 Canadian Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , All Races, Males All Sites Prostate Lung & Bronchus Colon & Rectum Bladder Melanoma of the Skin Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Nebraska 23, , , , , New Hampshire 19, , , , , , New Jersey 123, , , , , , New Mexico 23, , , , , , New York 271, , , , , , North Carolina 126, , , , , , North Dakota 9, , , , Ohio 155, , , , , , Oklahoma 49, , , , , , Oregon 50, , , , , , Pennsylvania 196, , , , , , Rhode Island 14, , , , , South Carolina 62, , , , , , South Dakota 10, , , , Tennessee 87, , , , , , Texas 256, , , , , , Utah 24, , , , , , Vermont 9, , , Virginia 94, , , , , , Washington 85, , , , , , WA: Seattle/Puget Sound 61, , , , , , West Virginia 29, , , , , , Wisconsin 77, , , , , , Wyoming 6, , Rates are per 100,000 and are age-adjusted to the 1996 Canadian population standard. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: S.E. - Standard Error

38 UNITED STATES III-9 Combined Incidence All Races Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , All Races, Females All Sites Breast Lung & Bronchus Colon & Rectum Uterus Corpus & Uterus, NOS 3 Thyroid Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 3,588, ,043, , , , , Alabama 57, , , , , , Alaska 6, , Arizona 66, , , , , , California 385, , , , , , CA: Greater Bay Area 76, , , , , , CA: Los Angeles 96, , , , , , Colorado 51, , , , , , Connecticut 51, , , , , , Delaware 12, , , , District of Columbia 7, , Florida 251, , , , , , Georgia 101, , , , , , GA: Metropolitan Atlanta 32, , , , , , Hawaii 16, , , , , Idaho 16, , , , , Illinois 161, , , , , , Indiana 79, , , , , , Iowa 41, , , , , , Kansas 34, , , , , , Kentucky 59, , , , , , Louisiana 52, , , , , , Maine 20, , , , , Maryland 69, , , , , , Massachusetts 92, , , , , , Michigan 128, , , , , , MI: Metropolitan Detroit 54, , , , , , Mississippi 34, , , , , , Missouri 76, , , , , , Montana 12, , , ,

39 UNITED STATES Combined Incidence All Races III-10 Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , All Races, Females All Sites Breast Lung & Bronchus Colon & Rectum Uterus Corpus & Uterus, NOS 3 Thyroid Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Nebraska 22, , , , , New Hampshire 18, , , , , New Jersey 120, , , , , , New Mexico 21, , , , , , New York 265, , , , , , North Carolina 114, , , , , , North Dakota 8, , Ohio 149, , , , , , Oklahoma 44, , , , , , Oregon 48, , , , , , Pennsylvania 189, , , , , , Rhode Island 15, , , , , South Carolina 55, , , , , , South Dakota 9, , , , Tennessee 78, , , , , , Texas 236, , , , , , Utah 20, , , , , , Vermont 8, , , Virginia 89, , , , , , Washington 80, , , , , , WA: Seattle/Puget Sound 57, , , , , , West Virginia 26, , , , , , Wisconsin 71, , , , , , Wyoming 5, , Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: NOS - Not Otherwise Specified; S.E. - Standard Error

40 UNITED STATES III-11 Combined Incidence All Races Total Cancer Cases and Average Annual Age-adjusted (1996 Canadian Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , All Races, Females All Sites Breast Lung & Bronchus Colon & Rectum Uterus Corpus & Uterus, NOS 3 Thyroid Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 3,588, ,043, , , , , Alabama 57, , , , , , Alaska 6, , Arizona 66, , , , , , California 385, , , , , , CA: Greater Bay Area 76, , , , , , CA: Los Angeles 96, , , , , , Colorado 51, , , , , , Connecticut 51, , , , , , Delaware 12, , , , District of Columbia 7, , Florida 251, , , , , , Georgia 101, , , , , , GA: Metropolitan Atlanta 32, , , , , , Hawaii 16, , , , , Idaho 16, , , , , Illinois 161, , , , , , Indiana 79, , , , , , Iowa 41, , , , , , Kansas 34, , , , , , Kentucky 59, , , , , , Louisiana 52, , , , , , Maine 20, , , , , Maryland 69, , , , , , Massachusetts 92, , , , , , Michigan 128, , , , , , MI: Metropolitan Detroit 54, , , , , , Mississippi 34, , , , , , Missouri 76, , , , , , Montana 12, , , ,

41 UNITED STATES Combined Incidence All Races III-12 Total Cancer Cases and Average Annual Age-adjusted (1996 Canadian Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , All Races, Females All Sites Breast Lung & Bronchus Colon & Rectum Uterus Corpus & Uterus, NOS 3 Thyroid Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Nebraska 22, , , , , New Hampshire 18, , , , , New Jersey 120, , , , , , New Mexico 21, , , , , , New York 265, , , , , , North Carolina 114, , , , , , North Dakota 8, , Ohio 149, , , , , , Oklahoma 44, , , , , , Oregon 48, , , , , , Pennsylvania 189, , , , , , Rhode Island 15, , , , , South Carolina 55, , , , , , South Dakota 9, , , , Tennessee 78, , , , , , Texas 236, , , , , , Utah 20, , , , , , Vermont 8, , , Virginia 89, , , , , , Washington 80, , , , , , WA: Seattle/Puget Sound 57, , , , , , West Virginia 26, , , , , , Wisconsin 71, , , , , , Wyoming 5, , Rates are per 100,000 and are age-adjusted to the 1996 Canadian population standard. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: NOS - Not Otherwise Specified; S.E. - Standard Error

42 NAACCR U.S. Combined Incidence , The White Population Seattle Puget Sound Greater Bay Area Metro Detroit Los Angeles Washington D.C. Metro Atlanta Participating Registries UNITED STATES III-13 Combined Incidence White

43 Total Cancer Cases and Average Annual Age-adjusted Cancer Incidence Rates* NAACCR United States Combined, , White MALES (WHITE) FEMALES (WHITE) SITES Count Adj. Rate 2000 U.S. S.E. Adj. Rate 1996 Cdn S.E. Count Adj. Rate 2000 U.S. S.E. Adj. Rate 1996 Cdn S.E. All Sites (invasive & in situ bladder) 3,236, ,038, Oral Cavity & Pharynx 109, , Lip 6, , Tongue 33, , Major salivary gland 10, , Floor of mouth 5, , Gum & other mouth 11, , Nasopharynx 3, , Oropharynx 4, , Hypopharynx 7, , Digestive System 591, , Esophagus 53, , Stomach 50, , Small intestine 15, , Colon excl. rectum 201, , Rectum & rectosigmoid 92, , Anus, anal canal & anorectum 8, , Liver 58, , Gallbladder 4, , Pancreas 82, , Respiratory System 518, , Larynx 40, , Lung & bronchus 471, , Bones & Joints 6, , Soft Tissue (incl. heart) 23, , Skin (excl. basal & sq.) 182, , Melanomas of the skin 169, , Breast (excl. in situ) 8, , Female Genital System , Cervix uteri , Uterus Corpus , Uterus, NOS , Ovary , Male Genital System 881, Prostate 839, Testis 35, Penis 5, Urinary System 368, , Bladder (incl. in situ) 227, , Kidney & renal pelvis 133, , Ureter 5, , Eye & Orbit 6, , Brain & Other Nervous System 50, , Brain 48, , Endocrine System 47, , Thyroid gland 42, , Lymphomas 161, , Hodgkin Lymphoma 19, , Non-Hodgkin Lymphoma 142, , Multiple Myeloma 41, , Leukemias 100, , Acute lymphocytic 11, , Chronic lymphocytic 35, , Acute myeloid 27, , Chronic myeloid 12, , Other leukemias 13, , Mesothelioma 11, , Kaposi Sarcoma 3, Ill-defined & Unknown 122, , Selected tumors (non-invasive) Brain & ONS 1 (benign/borderline) 46, , Breast (in situ) 1, , * Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age and to the 1996 Canadian population standard. - Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. 1 Abbreviations: NOS - Not Otherwise Specified; ONS - Other Nervous System UNITED STATES Combined Incidence White III-14

44 UNITED STATES III-15 Combined Incidence White Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , White, Males All Sites Prostate Lung & Bronchus Colon & Rectum Bladder Melanoma of the Skin Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 3,236, , , , , , Alabama 51, , , , , , Alaska 5, , Arizona 63, , , , , , California 327, , , , , , CA: Greater Bay Area 59, , , , , , CA: Los Angeles 71, , , , , , Colorado 48, , , , , , Connecticut 46, , , , , , Delaware 11, , , District of Columbia 1, Florida 249, , , , , , Georgia 82, , , , , , GA: Metropolitan Atlanta 20, , , , , , Hawaii 6, , Idaho 18, , , , , , Illinois 137, , , , , , Indiana 73, , , , , , Iowa 42, , , , , , Kansas 35, , , , , , Kentucky 59, , , , , , Louisiana 45, , , , , , Maine 21, , , , , Maryland 49, , , , , , Massachusetts 81, , , , , , Michigan 119, , , , , , MI: Metropolitan Detroit 43, , , , , , Mississippi 28, , , , , , Missouri 70, , , , , , Montana 13, , , ,

45 UNITED STATES Combined Incidence White III-16 Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , White, Males All Sites Prostate Lung & Bronchus Colon & Rectum Bladder Melanoma of the Skin Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Nebraska 21, , , , , New Hampshire 19, , , , , , New Jersey 102, , , , , , New Mexico 20, , , , , , New York 218, , , , , , North Carolina 99, , , , , , North Dakota 8, , , Ohio 134, , , , , , Oklahoma 41, , , , , , Oregon 46, , , , , , Pennsylvania 172, , , , , , Rhode Island 13, , , , , South Carolina 46, , , , , , South Dakota 10, , , , Tennessee 75, , , , , , Texas 220, , , , , , Utah 23, , , , , , Vermont 9, , , Virginia 73, , , , , , Washington 78, , , , , , WA: Seattle/Puget Sound 54, , , , , , West Virginia 28, , , , , , Wisconsin 71, , , , , , Wyoming 6, , Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: S.E. - Standard Error

46 UNITED STATES III-17 Combined Incidence White Total Cancer Cases and Average Annual Age-adjusted (1996 Canadian Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , White, Males All Sites Prostate Lung & Bronchus Colon & Rectum Bladder Melanoma of the Skin Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 3,236, , , , , , Alabama 51, , , , , , Alaska 5, , Arizona 63, , , , , , California 327, , , , , , CA: Greater Bay Area 59, , , , , , CA: Los Angeles 71, , , , , , Colorado 48, , , , , , Connecticut 46, , , , , , Delaware 11, , , District of Columbia 1, Florida 249, , , , , , Georgia 82, , , , , , GA: Metropolitan Atlanta 20, , , , , , Hawaii 6, , Idaho 18, , , , , , Illinois 137, , , , , , Indiana 73, , , , , , Iowa 42, , , , , , Kansas 35, , , , , , Kentucky 59, , , , , , Louisiana 45, , , , , , Maine 21, , , , , Maryland 49, , , , , , Massachusetts 81, , , , , , Michigan 119, , , , , , MI: Metropolitan Detroit 43, , , , , , Mississippi 28, , , , , , Missouri 70, , , , , , Montana 13, , , ,

47 UNITED STATES Combined Incidence White III-18 Total Cancer Cases and Average Annual Age-adjusted (1996 Canadian Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , White, Males All Sites Prostate Lung & Bronchus Colon & Rectum Bladder Melanoma of the Skin Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Nebraska 21, , , , , New Hampshire 19, , , , , , New Jersey 102, , , , , , New Mexico 20, , , , , , New York 218, , , , , , North Carolina 99, , , , , , North Dakota 8, , , Ohio 134, , , , , , Oklahoma 41, , , , , , Oregon 46, , , , , , Pennsylvania 172, , , , , , Rhode Island 13, , , , , South Carolina 46, , , , , , South Dakota 10, , , , Tennessee 75, , , , , , Texas 220, , , , , , Utah 23, , , , , , Vermont 9, , , Virginia 73, , , , , , Washington 78, , , , , , WA: Seattle/Puget Sound 54, , , , , , West Virginia 28, , , , , , Wisconsin 71, , , , , , Wyoming 6, , Rates are per 100,000 and are age-adjusted to the 1996 Canadian population standard. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: S.E. - Standard Error

48 UNITED STATES III-19 Combined Incidence White Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , White, Females All Sites Breast Lung & Bronchus Colon & Rectum Uterus Corpus & Uterus, NOS 3 Thyroid Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 3,038, , , , , , Alabama 44, , , , , , Alaska 4, , Arizona 61, , , , , , California 311, , , , , , CA: Greater Bay Area 55, , , , , , CA: Los Angeles 71, , , , , , Colorado 47, , , , , , Connecticut 46, , , , , , Delaware 10, , , District of Columbia 1, Florida 220, , , , , , Georgia 73, , , , , , GA: Metropolitan Atlanta 19, , , , Hawaii 4, , Idaho 16, , , , Illinois 134, , , , , , Indiana 72, , , , , , Iowa 40, , , , , , Kansas 31, , , , , , Kentucky 55, , , , , , Louisiana 37, , , , , , Maine 19, , , , , Maryland 48, , , , , , Massachusetts 85, , , , , , Michigan 109, , , , , , MI: Metropolitan Detroit 40, , , , , , Mississippi 23, , , , , Missouri 67, , , , , , Montana 11, , , ,

49 UNITED STATES Combined Incidence White III-20 Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , White, Females All Sites Breast Lung & Bronchus Colon & Rectum Uterus Corpus & Uterus, NOS 3 Thyroid Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Nebraska 20, , , , , New Hampshire 17, , , , , New Jersey 100, , , , , , New Mexico 18, , , , , New York 214, , , , , , North Carolina 90, , , , , , North Dakota 7, , Ohio 131, , , , , , Oklahoma 37, , , , , , Oregon 45, , , , , , Pennsylvania 168, , , , , , Rhode Island 14, , , , South Carolina 41, , , , , , South Dakota 9, , , , Tennessee 67, , , , , , Texas 202, , , , , , Utah 19, , , , , , Vermont 8, , , Virginia 69, , , , , , Washington 73, , , , , , WA: Seattle/Puget Sound 50, , , , , , West Virginia 25, , , , , Wisconsin 66, , , , , , Wyoming 5, , Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: NOS - Not Otherwise Specified; S.E. - Standard Error

50 UNITED STATES III-21 Combined Incidence White Total Cancer Cases and Average Annual Age-adjusted (1996 Canadian Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , White, Females All Sites Breast Lung & Bronchus Colon & Rectum Uterus Corpus & Uterus, NOS 3 Thyroid Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 3,038, , , , , , Alabama 44, , , , , , Alaska 4, , Arizona 61, , , , , , California 311, , , , , , CA: Greater Bay Area 55, , , , , , CA: Los Angeles 71, , , , , , Colorado 47, , , , , , Connecticut 46, , , , , , Delaware 10, , , District of Columbia 1, Florida 220, , , , , , Georgia 73, , , , , , GA: Metropolitan Atlanta 19, , , , Hawaii 4, , Idaho 16, , , , Illinois 134, , , , , , Indiana 72, , , , , , Iowa 40, , , , , , Kansas 31, , , , , , Kentucky 55, , , , , , Louisiana 37, , , , , , Maine 19, , , , , Maryland 48, , , , , , Massachusetts 85, , , , , , Michigan 109, , , , , , MI: Metropolitan Detroit 40, , , , , , Mississippi 23, , , , , Missouri 67, , , , , , Montana 11, , , ,

51 UNITED STATES Combined Incidence White III-22 Total Cancer Cases and Average Annual Age-adjusted (1996 Canadian Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , White, Females All Sites Breast Lung & Bronchus Colon & Rectum Uterus Corpus & Uterus, NOS 3 Thyroid Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Nebraska 20, , , , , New Hampshire 17, , , , , New Jersey 100, , , , , , New Mexico 18, , , , , New York 214, , , , , , North Carolina 90, , , , , , North Dakota 7, , Ohio 131, , , , , , Oklahoma 37, , , , , , Oregon 45, , , , , , Pennsylvania 168, , , , , , Rhode Island 14, , , , South Carolina 41, , , , , , South Dakota 9, , , , Tennessee 67, , , , , , Texas 202, , , , , , Utah 19, , , , , , Vermont 8, , , Virginia 69, , , , , , Washington 73, , , , , , WA: Seattle/Puget Sound 50, , , , , , West Virginia 25, , , , , Wisconsin 66, , , , , , Wyoming 5, , Rates are per 100,000 and are age-adjusted to the 1996 Canadian population standard. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: NOS - Not Otherwise Specified; S.E. - Standard Error

52 NAACCR U.S. Combined Incidence , The Black Population Seattle Puget Sound Greater Bay Area Metro Detroit Los Angeles Washington D.C. Metro Atlanta Participating Registries UNITED STATES III-23 Combined Incidence Black

53 Total Cancer Cases and Average Annual Age-adjusted Cancer Incidence Rates* NAACCR United States Combined, , Black MALES (BLACK) FEMALES (BLACK) SITES Count Adj. Rate 2000 U.S. S.E. Adj. Rate 1996 Cdn S.E. Count Adj. Rate 2000 U.S. S.E. Adj. Rate 1996 Cdn S.E. All Sites (invasive & in situ bladder) 414, , Oral Cavity & Pharynx 11, , Lip Tongue 2, , Major salivary gland Floor of mouth Gum & other mouth 1, , Nasopharynx Oropharynx Hypopharynx 1, Digestive System 87, , Esophagus 5, , Stomach 9, , Small intestine 2, , Colon excl. rectum 29, , Rectum & rectosigmoid 11, , Anus, anal canal & anorectum 1, , Liver 12, , Gallbladder , Pancreas 11, , Respiratory System 68, , Larynx 6, , Lung & bronchus 60, , Bones & Joints Soft Tissue (incl. heart) 2, , Skin (excl. basal & sq.) 1, , Melanomas of the skin Breast (excl. in situ) 1, , Female Genital System , Cervix uteri , Uterus Corpus , Uterus, NOS , Ovary , Male Genital System 155, Prostate 153, Testis 1, Penis Urinary System 29, , Bladder (incl. in situ) 11, , Kidney & renal pelvis 17, , Ureter Eye & Orbit Brain & Other Nervous System 3, , Brain 3, , Endocrine System 3, , Thyroid gland 2, , Lymphomas 15, , Hodgkin Lymphoma 2, , Non-Hodgkin Lymphoma 12, , Multiple Myeloma 9, , Leukemias 8, , Acute lymphocytic 1, Chronic lymphocytic 2, , Acute myeloid 2, , Chronic myeloid 1, , Other leukemias 1, , Mesothelioma Kaposi Sarcoma 1, Ill-defined & Unknown 12, , Selected tumors (non-invasive) Brain & ONS 1 (benign/borderline) 5, , Breast (in situ) , * Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age and to the 1996 Canadian population standard. - Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. 1 Abbreviations: NOS - Not Otherwise Specified; ONS - Other Nervous System UNITED STATES Combined Incidence Black III-24

54 UNITED STATES III-25 Combined Incidence Black Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Black, Males All Sites Prostate Lung & Bronchus Colon & Rectum Kidney & Renal Pelvis Non-Hodgkin Lymphoma Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 414, , , , , , Alabama 13, , , , Alaska Arizona 1, California 27, , , , , CA: Greater Bay Area 5, , CA: Los Angeles 11, , , , Colorado 1, Connecticut 3, , Delaware 2, District of Columbia 4, , Florida 28, , , , , Georgia 28, , , , , GA: Metropolitan Atlanta 11, , , , Hawaii Idaho Illinois 22, , , , Indiana 5, , , Iowa Kansas 1, Kentucky 3, , Louisiana 17, , , , Maine Maryland 17, , , , Massachusetts 4, , Michigan 17, , , , MI: Metropolitan Detroit 13, , , , Mississippi 12, , , , Missouri 7, , , Montana

55 UNITED STATES Combined Incidence Black III-26 Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Black, Males All Sites Prostate Lung & Bronchus Colon & Rectum Kidney & Renal Pelvis Non-Hodgkin Lymphoma Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Nebraska New Hampshire New Jersey 13, , , , New Mexico New York 37, , , , , , North Carolina 23, , , , , North Dakota Ohio 15, , , , Oklahoma 2, , Oregon Pennsylvania 16, , , , Rhode Island South Carolina 14, , , , South Dakota Tennessee 10, , , , Texas 28, , , , , Utah Vermont Virginia 17, , , , Washington 2, WA: Seattle/Puget Sound 2, West Virginia Wisconsin 3, , Wyoming Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: S.E. - Standard Error

56 UNITED STATES III-27 Combined Incidence Black Total Cancer Cases and Average Annual Age-adjusted (1996 Canadian Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Black, Males All Sites Prostate Lung & Bronchus Colon & Rectum Kidney & Renal Pelvis Non-Hodgkin Lymphoma Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 414, , , , , , Alabama 13, , , , Alaska Arizona 1, California 27, , , , , CA: Greater Bay Area 5, , CA: Los Angeles 11, , , , Colorado 1, Connecticut 3, , Delaware 2, District of Columbia 4, , Florida 28, , , , , Georgia 28, , , , , GA: Metropolitan Atlanta 11, , , , Hawaii Idaho Illinois 22, , , , Indiana 5, , , Iowa Kansas 1, Kentucky 3, , Louisiana 17, , , , Maine Maryland 17, , , , Massachusetts 4, , Michigan 17, , , , MI: Metropolitan Detroit 13, , , , Mississippi 12, , , , Missouri 7, , , Montana

57 UNITED STATES Combined Incidence Black III-28 Total Cancer Cases and Average Annual Age-adjusted (1996 Canadian Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Black, Males All Sites Prostate Lung & Bronchus Colon & Rectum Kidney & Renal Pelvis Non-Hodgkin Lymphoma Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Nebraska New Hampshire New Jersey 13, , , , New Mexico New York 37, , , , , , North Carolina 23, , , , , North Dakota Ohio 15, , , , Oklahoma 2, , Oregon Pennsylvania 16, , , , Rhode Island South Carolina 14, , , , South Dakota Tennessee 10, , , , Texas 28, , , , , Utah Vermont Virginia 17, , , , Washington 2, WA: Seattle/Puget Sound 2, West Virginia Wisconsin 3, , Wyoming Rates are per 100,000 and are age-adjusted to the 1996 Canadian population standard. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: S.E. - Standard Error

58 UNITED STATES III-29 Combined Incidence Black Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Black, Females All Sites Breast Lung & Bronchus Colon & Rectum Uterus Corpus & Uterus, NOS 3 Pancreas Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 380, , , , , , Alabama 12, , , , Alaska Arizona 1, California 24, , , , , CA: Greater Bay Area 5, , CA: Los Angeles 10, , , , Colorado 1, Connecticut 3, , Delaware 1, District of Columbia 4, , Florida 25, , , , , Georgia 25, , , , , GA: Metropolitan Atlanta 11, , , , Hawaii Idaho Illinois 21, , , , , Indiana 5, , Iowa Kansas 1, Kentucky 3, , Louisiana 14, , , , Maine Maryland 17, , , , , Massachusetts 3, , Michigan 15, , , , MI: Metropolitan Detroit 12, , , , Mississippi 10, , , , Missouri 7, , , Montana

59 UNITED STATES Combined Incidence Black III-30 Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Black, Females All Sites Breast Lung & Bronchus Colon & Rectum Uterus Corpus & Uterus, NOS 3 Pancreas Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Nebraska New Hampshire New Jersey 13, , , , New Mexico New York 35, , , , , , North Carolina 21, , , , , North Dakota Ohio 14, , , , Oklahoma 2, Oregon Pennsylvania 16, , , , Rhode Island South Carolina 12, , , , South Dakota Tennessee 10, , , , Texas 26, , , , , Utah Vermont Virginia 15, , , , Washington 1, WA: Seattle/Puget Sound 1, West Virginia Wisconsin 3, Wyoming Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: NOS - Not Otherwise Specified; S.E. - Standard Error

60 UNITED STATES III-31 Combined Incidence Black Total Cancer Cases and Average Annual Age-adjusted (1996 Canadian Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Black, Females All Sites Breast Lung & Bronchus Colon & Rectum Uterus Corpus & Uterus, NOS 3 Pancreas Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 380, , , , , , Alabama 12, , , , Alaska Arizona 1, California 24, , , , , CA: Greater Bay Area 5, , CA: Los Angeles 10, , , , Colorado 1, Connecticut 3, , Delaware 1, District of Columbia 4, , Florida 25, , , , , Georgia 25, , , , , GA: Metropolitan Atlanta 11, , , , Hawaii Idaho Illinois 21, , , , , Indiana 5, , Iowa Kansas 1, Kentucky 3, , Louisiana 14, , , , Maine Maryland 17, , , , , Massachusetts 3, , Michigan 15, , , , MI: Metropolitan Detroit 12, , , , Mississippi 10, , , , Missouri 7, , , Montana

61 UNITED STATES Combined Incidence Black III-32 Total Cancer Cases and Average Annual Age-adjusted (1996 Canadian Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Black, Females All Sites Breast Lung & Bronchus Colon & Rectum Uterus Corpus & Uterus, NOS 3 Pancreas Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Nebraska New Hampshire New Jersey 13, , , , New Mexico New York 35, , , , , , North Carolina 21, , , , , North Dakota Ohio 14, , , , Oklahoma 2, Oregon Pennsylvania 16, , , , Rhode Island South Carolina 12, , , , South Dakota Tennessee 10, , , , Texas 26, , , , , Utah Vermont Virginia 15, , , , Washington 1, WA: Seattle/Puget Sound 1, West Virginia Wisconsin 3, Wyoming Rates are per 100,000 and are age-adjusted to the 1996 Canadian population standard. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: NOS - Not Otherwise Specified; S.E. - Standard Error

62 NAACCR U.S. Combined Incidence , The Asian/Pacific Islander Population Seattle Puget Sound Greater Bay Area Metro Detroit Los Angeles Washington D.C. Metro Atlanta Participating Registries UNITED STATES III-33 Combined Incidence Asian/Pacific Islander

63 Total Cancer Cases and Average Annual Age-adjusted Cancer Incidence Rates* NAACCR United States Combined, , Asian/Pacific Islander (API) MALES (API) FEMALES (API) SITES Count Adj. Rate 2000 U.S. S.E. Adj. Rate 1996 Cdn S.E. Count Adj. Rate 2000 U.S. S.E. Adj. Rate 1996 Cdn S.E. All Sites (invasive & in situ bladder) 92, , Oral Cavity & Pharynx 3, , Lip Tongue Major salivary gland Floor of mouth Gum & other mouth Nasopharynx 1, Oropharynx Hypopharynx Digestive System 27, , Esophagus 1, Stomach 4, , Small intestine Colon excl. rectum 7, , Rectum & rectosigmoid 4, , Anus, anal canal & anorectum Liver 6, , Gallbladder Pancreas 2, , Respiratory System 13, , Larynx Lung & bronchus 12, , Bones & Joints Soft Tissue (incl. heart) Skin (excl. basal & sq.) Melanomas of the skin Breast (excl. in situ) , Female Genital System , Cervix uteri , Uterus Corpus , Uterus, NOS Ovary , Male Genital System 21, Prostate 20, Testis Penis Urinary System 7, , Bladder (incl. in situ) 3, , Kidney & renal pelvis 3, , Ureter Eye & Orbit Brain & Other Nervous System 1, , Brain 1, , Endocrine System 2, , Thyroid gland 2, , Lymphomas 5, , Hodgkin Lymphoma Non-Hodgkin Lymphoma 4, , Multiple Myeloma 1, , Leukemias 2, , Acute lymphocytic Chronic lymphocytic Acute myeloid 1, , Chronic myeloid Other leukemias Mesothelioma Kaposi Sarcoma Ill-defined & Unknown 3, , Selected tumors (non-invasive) Brain & ONS 1 (benign/borderline) 1, , Breast (in situ) , * Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age and to the 1996 Canadian population standard. - Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined 1 Abbreviations: NOS - Not Otherwise Specified; ONS - Other Nervous System. UNITED STATES Combined Incidence Asian/Pacific Islander III-34

64 UNITED STATES III-35 Combined Incidence Asian/Pacific Islander Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Asian/Pacific Islander, Males All Sites Prostate Lung & Bronchus Colon & Rectum Liver & IBD 3 Lymphoma Non-Hodgkin Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 92, , , , , , Alabama Alaska Arizona California 36, , , , , , CA: Greater Bay Area 12, , , , CA: Los Angeles 11, , , , Colorado Connecticut Delaware District of Columbia Florida 2, Georgia 1, GA: Metropolitan Atlanta Hawaii 10, , , , Idaho Illinois 3, Indiana Iowa Kansas Kentucky Louisiana Maine Maryland 1, Massachusetts 1, Michigan 1, MI: Metropolitan Detroit Mississippi Missouri Montana

65 UNITED STATES Combined Incidence Asian/Pacific Islander III-36 Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Asian/Pacific Islander, Males All Sites Prostate Lung & Bronchus Colon & Rectum Liver & IBD 3 Lymphoma Non-Hodgkin Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Nebraska New Hampshire New Jersey 3, New Mexico New York 10, , , , North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania 1, Rhode Island South Carolina South Dakota Tennessee Texas 3, Utah Vermont Virginia 2, Washington 3, WA: Seattle/Puget Sound 3, West Virginia Wisconsin Wyoming Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: IBD - Intrahepatic Bile Duct; S.E. - Standard Error

66 UNITED STATES III-37 Combined Incidence Asian/Pacific Islander Total Cancer Cases and Average Annual Age-adjusted (1996 Canadian Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Asian/Pacific Islander, Males All Sites Prostate Lung & Bronchus Colon & Rectum Liver & IBD 3 Lymphoma Non-Hodgkin Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 92, , , , , , Alabama Alaska Arizona California 36, , , , , , CA: Greater Bay Area 12, , , , CA: Los Angeles 11, , , , Colorado Connecticut Delaware District of Columbia Florida 2, Georgia 1, GA: Metropolitan Atlanta Hawaii 10, , , , Idaho Illinois 3, Indiana Iowa Kansas Kentucky Louisiana Maine Maryland 1, Massachusetts 1, Michigan 1, MI: Metropolitan Detroit Mississippi Missouri Montana

67 UNITED STATES Combined Incidence Asian/Pacific Islander III-38 Total Cancer Cases and Average Annual Age-adjusted (1996 Canadian Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Asian/Pacific Islander, Males All Sites Prostate Lung & Bronchus Colon & Rectum Liver & IBD 3 Lymphoma Non-Hodgkin Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Nebraska New Hampshire New Jersey 3, New Mexico New York 10, , , , North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania 1, Rhode Island South Carolina South Dakota Tennessee Texas 3, Utah Vermont Virginia 2, Washington 3, WA: Seattle/Puget Sound 3, West Virginia Wisconsin Wyoming Rates are per 100,000 and are age-adjusted to the 1996 Canadian population standard. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: IBD - Intrahepatic Bile Duct; S.E. - Standard Error

68 UNITED STATES III-39 Combined Incidence Asian/Pacific Islander Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Asian/Pacific Islander, Females All Sites Breast Colon & Rectum Lung & Bronchus Thyroid Uterus Corpus & Uterus, NOS 3 Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 108, , , , , , Alabama Alaska Arizona 1, California 42, , , , , , CA: Greater Bay Area 14, , , , CA: Los Angeles 13, , , , Colorado Connecticut Delaware District of Columbia Florida 2, Georgia 1, GA: Metropolitan Atlanta 1, Hawaii 11, , , , Idaho Illinois 3, , Indiana Iowa Kansas Kentucky Louisiana Maine Maryland 2, Massachusetts 2, Michigan 1, MI: Metropolitan Detroit Mississippi Missouri Montana

69 UNITED STATES Combined Incidence Asian/Pacific Islander III-40 Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Asian/Pacific Islander, Females All Sites Breast Colon & Rectum Lung & Bronchus Thyroid Uterus Corpus & Uterus, NOS 3 Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Nebraska New Hampshire New Jersey 4, , New Mexico New York 11, , , , North Carolina 1, North Dakota Ohio Oklahoma Oregon 1, Pennsylvania 1, Rhode Island South Carolina South Dakota Tennessee Texas 4, , Utah Vermont Virginia 2, Washington 4, , WA: Seattle/Puget Sound 3, , West Virginia Wisconsin Wyoming Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: NOS - Not Otherwise Specified; S.E. - Standard Error

70 UNITED STATES III-41 Combined Incidence Asian/Pacific Islander Total Cancer Cases and Average Annual Age-adjusted (1996 Canadian Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Asian/Pacific Islander, Females All Sites Breast Colon & Rectum Lung & Bronchus Thyroid Uterus Corpus & Uterus, NOS 3 Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 108, , , , , , Alabama Alaska Arizona 1, California 42, , , , , , CA: Greater Bay Area 14, , , , CA: Los Angeles 13, , , , Colorado Connecticut Delaware District of Columbia Florida 2, Georgia 1, GA: Metropolitan Atlanta 1, Hawaii 11, , , , Idaho Illinois 3, , Indiana Iowa Kansas Kentucky Louisiana Maine Maryland 2, Massachusetts 2, Michigan 1, MI: Metropolitan Detroit Mississippi Missouri Montana

71 UNITED STATES Combined Incidence Asian/Pacific Islander III-42 Total Cancer Cases and Average Annual Age-adjusted (1996 Canadian Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Asian/Pacific Islander, Females All Sites Breast Colon & Rectum Lung & Bronchus Thyroid Uterus Corpus & Uterus, NOS 3 Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Nebraska New Hampshire New Jersey 4, , New Mexico New York 11, , , , North Carolina 1, North Dakota Ohio Oklahoma Oregon 1, Pennsylvania 1, Rhode Island South Carolina South Dakota Tennessee Texas 4, , Utah Vermont Virginia 2, Washington 4, , WA: Seattle/Puget Sound 3, , West Virginia Wisconsin Wyoming Rates are per 100,000 and are age-adjusted to the 1996 Canadian population standard. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: NOS - Not Otherwise Specified; S.E. - Standard Error

72 NAACCR U.S. Combined Incidence , The American Indian/Alaskan Native CHSDA Counties Population UNITED STATES III-43 Combined Incidence American Indian/Alaskan Native

73 Total Cancer Cases and Average Annual Age-adjusted Cancer Incidence Rates* NAACCR United States Combined, , American Indian/Alaskan Native (AI/AN) for CHSDA 1 Counties MALES (AI/AN) FEMALES (AI/AN) SITES Count Adj. Rate 2000 U.S. S.E. Adj. Rate 1996 Cdn S.E. Count Adj. Rate 2000 U.S. S.E. Adj. Rate 1996 Cdn S.E. All Sites (invasive & in situ bladder) 12, , Oral Cavity & Pharynx Lip Tongue Major salivary gland Floor of mouth Gum & other mouth Nasopharynx Oropharynx Hypopharynx Digestive System 3, , Esophagus Stomach Small intestine Colon excl. rectum , Rectum & rectosigmoid Anus, anal canal & anorectum Liver Gallbladder Pancreas Respiratory System 1, , Larynx Lung & bronchus 1, , Bones & Joints Soft Tissue (incl. heart) Skin (excl. basal & sq.) Melanomas of the skin Breast (excl. in situ) , Female Genital System , Cervix uteri Uterus Corpus Uterus, NOS Ovary Male Genital System 2, Prostate 2, Testis Penis Urinary System 1, Bladder (incl. in situ) Kidney & renal pelvis Ureter Eye & Orbit Brain & Other Nervous System Brain Endocrine System Thyroid gland Lymphomas Hodgkin Lymphoma Non-Hodgkin Lymphoma Multiple Myeloma Leukemias Acute lymphocytic Chronic lymphocytic Acute myeloid Chronic myeloid Other leukemias Mesothelioma Kaposi Sarcoma Ill-defined & Unknown Selected tumors (non-invasive) Brain & ONS 1 (benign/borderline) Breast (in situ) * Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age and to the 1996 Canadian population standard. Statistics exclude data for KS for all years. - Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. 1 CHSDA - Indian Health Services Contract Health Service Delivery Areas (See Appendix G) 2 Abbreviations: NOS - Not Otherwise Specified; ONS - Other Nervous System UNITED STATES Combined Incidence American Indian/Alaskan Native III-44

74 UNITED STATES III-45 Combined Incidence American Indian/Alaskan Native Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , American Indian/Alaskan Native for CHSDA 3 Counties, Males All Sites Prostate Lung & Bronchus Colon & Rectum Kidney & Renal Pelvis Liver & IBD 4 Count Rate S.E. 4 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 12, , , , Alabama Alaska Arizona 1, California Colorado Connecticut Florida Idaho Indiana Iowa Louisiana Maine Massachusetts Michigan Mississippi Montana Nebraska New Mexico 1, New York North Carolina North Dakota Oklahoma 3, Oregon Pennsylvania Rhode Island South Carolina South Dakota Texas

75 Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , American Indian/Alaskan Native for CHSDA 3 Counties, Males All Sites Prostate Lung & Bronchus Colon & Rectum Kidney & Renal Pelvis Liver & IBD 4 Count Rate S.E. 4 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Utah Washington 1, WA: Seattle/Puget Sound Wisconsin Wyoming Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. Statistics exclude data for KS for all years. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. CHSDA - Indian Health Services Contract Health Service Delivery Areas (See Appendix G) 4. Abbreviations: IBD - Intrahepatic Bile Duct; S.E. - Standard Error UNITED STATES Combined Incidence American Indian/Alaskan Native III-46

76 UNITED STATES III-47 Combined Incidence American Indian/Alaskan Native Total Cancer Cases and Average Annual Age-adjusted (1996 Canadian Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , American Indian/Alaskan Native for CHSDA 3 Counties, Males All Sites Prostate Lung & Bronchus Colon & Rectum Kidney & Renal Pelvis Liver & IBD 4 Count Rate S.E. 4 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 12, , , , Alabama Alaska Arizona 1, California Colorado Connecticut Florida Idaho Indiana Iowa Louisiana Maine Massachusetts Michigan Mississippi Montana Nebraska New Mexico 1, New York North Carolina North Dakota Oklahoma 3, Oregon Pennsylvania Rhode Island South Carolina South Dakota Texas

77 Total Cancer Cases and Average Annual Age-adjusted (1996 Canadian Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , American Indian/Alaskan Native for CHSDA 3 Counties, Males All Sites Prostate Lung & Bronchus Colon & Rectum Kidney & Renal Pelvis Liver & IBD 4 Count Rate S.E. 4 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Utah Washington 1, WA: Seattle/Puget Sound Wisconsin Wyoming Rates are per 100,000 and are age-adjusted to the 1996 Canadian population standard. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. Statistics exclude data for KS for all years. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. CHSDA - Indian Health Services Contract Health Service Delivery Areas (See Appendix G) 4. Abbreviations: IBD - Intrahepatic Bile Duct; S.E. - Standard Error UNITED STATES Combined Incidence American Indian/Alaskan Native III-48

78 UNITED STATES III-49 Combined Incidence American Indian/Alaskan Native Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , American Indian/Alaskan Native for CHSDA 3 Counties, Females All Sites Breast Lung & Bronchus Colon & Rectum Uterus Corpus & Uterus, NOS 4 Kidney & Renal Pelvis Count Rate S.E. 4 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 13, , , , Alabama Alaska 1, Arizona 1, California Colorado Connecticut Florida Idaho Indiana Iowa Louisiana Maine Massachusetts Michigan Mississippi Montana Nebraska New Mexico 1, New York North Carolina North Dakota Oklahoma 3, , Oregon Pennsylvania Rhode Island South Carolina South Dakota Texas

79 Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , American Indian/Alaskan Native for CHSDA 3 Counties, Females All Sites Breast Lung & Bronchus Colon & Rectum Uterus Corpus & Uterus, NOS 4 Kidney & Renal Pelvis Count Rate S.E. 4 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Utah Washington 1, WA: Seattle/Puget Sound Wisconsin Wyoming Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. Statistics exclude data for KS for all years. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. CHSDA - Indian Health Services Contract Health Service Delivery Areas (See Appendix G) 4. Abbreviations: NOS - Not Otherwise Specified; S.E. - Standard Error UNITED STATES Combined Incidence American Indian/Alaskan Native III-50

80 UNITED STATES III-51 Combined Incidence American Indian/Alaskan Native Total Cancer Cases and Average Annual Age-adjusted (1996 Canadian Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , American Indian/Alaskan Native for CHSDA 3 Counties, Females All Sites Breast Lung & Bronchus Colon & Rectum Uterus Corpus & Uterus, NOS 4 Kidney & Renal Pelvis Count Rate S.E. 4 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 13, , , , Alabama Alaska 1, Arizona 1, California Colorado Connecticut Florida Idaho Indiana Iowa Louisiana Maine Massachusetts Michigan Mississippi Montana Nebraska New Mexico 1, New York North Carolina North Dakota Oklahoma 3, , Oregon Pennsylvania Rhode Island South Carolina South Dakota Texas

81 Total Cancer Cases and Average Annual Age-adjusted (1996 Canadian Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , American Indian/Alaskan Native for CHSDA 3 Counties, Females All Sites Breast Lung & Bronchus Colon & Rectum Uterus Corpus & Uterus, NOS 4 Kidney & Renal Pelvis Count Rate S.E. 4 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Utah Washington 1, WA: Seattle/Puget Sound Wisconsin Wyoming Rates are per 100,000 and are age-adjusted to the 1996 Canadian population standard. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. Statistics exclude data for KS for all years. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. CHSDA - Indian Health Services Contract Health Service Delivery Areas (See Appendix G) 4. Abbreviations: NOS - Not Otherwise Specified; S.E. - Standard Error UNITED STATES Combined Incidence American Indian/Alaskan Native III-52

82 Total Cancer Cases and Average Annual Age-Adjusted Cancer Incidence Rates* Most Frequent Cancer Sites by IHS 1 Region, NAACCR U.S. Combined Selected CHSDA 1 Counties , American Indian/Alaskan Native, Males U.S. (CHSDA Counties) Northern Plains Cancer site or type Rank Count Rate 95% CI S.E. Rank Count Rate 95% CI S.E. All Sites 12, , Prostate 1 2, Lung & Bronchus 2 1, Colon & Rectum 3 1, Kidney & Renal Pelvis Liver and Intrahepatic Bile Duct Non-Hodgkin Lymphoma Oral Cavity & Pharynx Urinary Bladder Leukemia Pancreas Stomach Testis Esophagus Melanoma of the Skin Brain & Other Nervous System Larynx Myeloma Thyroid Alaska Southern Plains Cancer site or type Rank Count Rate 95% CI S.E. Rank Count Rate 95% CI S.E. All Sites , Prostate Lung & Bronchus Colon & Rectum Kidney & Renal Pelvis Liver and Intrahepatic Bile Duct Non-Hodgkin Lymphoma Oral Cavity & Pharynx Urinary Bladder Leukemia Pancreas Stomach Testis Esophagus Melanoma of the Skin Brain & Other Nervous System Larynx Myeloma Thyroid * Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. The rates are based on cases and populations included in the combined incidence for the United States excluding KS. 1 Abbreviations: IHS - Indian Health Services; CHSDA - Contract Health Service Delivery Area ~ Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. UNITED STATES III-53 Combined Incidence American Indian/Alaskan Native

83 Total Cancer Cases and Average Annual Age-Adjusted Cancer Incidence Rates* Most Frequent Cancer Sites by IHS 1 Region, NAACCR U.S. Combined Selected CHSDA 1 Counties , American Indian/Alaskan Native, Males Pacific Coast Cancer site or type Rank Count Rate 95% CI S.E. Rank Count Rate 95% CI S.E. All Sites 2, Prostate Lung & Bronchus Colon & Rectum Kidney & Renal Pelvis Liver and Intrahepatic Bile Duct Non-Hodgkin Lymphoma Oral Cavity & Pharynx Urinary Bladder Leukemia Pancreas Stomach Testis Esophagus Melanoma of the Skin Brain & Other Nervous System Larynx Myeloma Thyroid East Southwest Cancer site or type Rank Count Rate 95% CI S.E. All Sites 2, Prostate Lung & Bronchus Colon & Rectum Kidney & Renal Pelvis Liver and Intrahepatic Bile Duct Non-Hodgkin Lymphoma Oral Cavity & Pharynx Urinary Bladder Leukemia Pancreas Stomach Testis Esophagus Melanoma of the Skin Brain & Other Nervous System Larynx Myeloma Thyroid * Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. The rates are based on cases and populations included in the combined incidence for the United States excluding KS. 1 Abbreviations: IHS - Indian Health Services; CHSDA - Contract Health Service Delivery Area ~ Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. UNITED STATES Combined Incidence American Indian/Alaskan Native III-54

84 Total Cancer Cases and Average Annual Age-Adjusted Cancer Incidence Rates* Most Frequent Cancer Sites by IHS 1 Region, NAACCR U.S. Combined Selected CHSDA 1 Counties , American Indian/Alaskan Native, Females U.S. (CHSDA Counties) Northern Plains Cancer site or type Rank Count Rate 95% CI S.E. Rank Count Rate 95% CI S.E. All Sites 13, , Breast 1 3, Lung & Bronchus 2 1, Colon & Rectum 3 1, Corpus & Uterus, NOS Kidney & Renal Pelvis Thyroid Non-Hodgkin Lymphoma Ovary Cervix Uteri Leukemia Pancreas Liver and Intrahepatic Bile Duct Stomach Melanoma of the Skin Oral Cavity & Pharynx Brain & Other Nervous System Myeloma Urinary Bladder Alaska Southern Plains Cancer site or type Rank Count Rate 95% CI S.E. Rank Count Rate 95% CI S.E. All Sites 1, , Breast , Lung & Bronchus Colon & Rectum Corpus & Uterus, NOS Kidney & Renal Pelvis Thyroid Non-Hodgkin Lymphoma Ovary Cervix Uteri Pancreas Leukemia Liver and Intrahepatic Bile Duct Stomach Melanoma of the Skin ~ ~ ~ ~ ~ Oral Cavity & Pharynx Brain & Other Nervous System Myeloma Urinary Bladder * Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. The rates are based on cases and populations included in the combined incidence for the United States excluding KS. 1 Abbreviations: IHS - Indian Health Services; CHSDA - Contract Health Service Delivery Area ~ Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. UNITED STATES III-55 Combined Incidence American Indian/Alaskan Native

85 Total Cancer Cases and Average Annual Age-Adjusted Cancer Incidence Rates* Most Frequent Cancer Sites by IHS 1 Region, NAACCR U.S. Combined Selected CHSDA 1 Counties , American Indian/Alaskan Native, Females Pacific Coast Cancer site or type Rank Count Rate 95% CI S.E. Rank Count Rate 95% CI S.E. All Sites 2, Breast Lung & Bronchus Colon & Rectum Corpus & Uterus, NOS Kidney & Renal Pelvis Thyroid Non-Hodgkin Lymphoma Ovary Cervix Uteri Pancreas Leukemia Liver and Intrahepatic Bile Duct Stomach Melanoma of the Skin Oral Cavity & Pharynx Brain & Other Nervous System Myeloma Urinary Bladder East Southwest Cancer site or type Rank Count Rate 95% CI S.E. All Sites 2, Breast Lung & Bronchus Colon & Rectum Corpus & Uterus, NOS Kidney & Renal Pelvis Thyroid Non-Hodgkin Lymphoma Ovary Cervix Uteri Pancreas Leukemia Liver and Intrahepatic Bile Duct Stomach Melanoma of the Skin Oral Cavity & Pharynx Brain & Other Nervous System Myeloma Urinary Bladder * Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. The rates are based on cases and populations included in the combined incidence for the United States excluding KS. 1 Abbreviations: IHS - Indian Health Services; CHSDA - Contract Health Service Delivery Area ~ Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. UNITED STATES Combined Incidence American Indian/Alaskan Native III-56

86 NAACCR United States Combined Incidence , Hispanic/Latino, All Races Combined Seattle Puget Sound Greater Bay Area Metro Detroit Los Angeles Washington D.C. Metro Atlanta Participating Registries UNITED STATES III-57 Combined Incidence Hispanic/Latino, All Races

87 Total Cancer Cases and Average Annual Age-adjusted Cancer Incidence Rates* NAACCR United States Combined, , Hispanic/Latino, All Races MALES (HISPANIC/LATINO) FEMALES (HISPANIC/LATINA) SITES Count Adj. Rate 2000 U.S. S.E. Adj. Rate 1996 Cdn S.E. Count Adj. Rate 2000 US. S.E. Adj. Rate 1996 Cdn S.E. All Sites (invasive & in situ bladder) 253, , Oral Cavity & Pharynx 7, , Lip Tongue 1, Major salivary gland Floor of mouth Gum & other mouth Nasopharynx Oropharynx Hypopharynx Digestive System 61, , Esophagus 3, Stomach 7, , Small intestine 1, , Colon excl. rectum 17, , Rectum & rectosigmoid 9, , Anus, anal canal & anorectum , Liver 11, , Gallbladder , Pancreas 6, , Respiratory System 26, , Larynx 3, Lung & bronchus 22, , Bones & Joints 1, Soft Tissue (incl. heart) 2, , Skin (excl. basal & sq.) 3, , Melanomas of the skin 2, , Breast (excl. in situ) , Female Genital System , Cervix uteri , Uterus Corpus , Uterus, NOS Ovary , Male Genital System 74, Prostate 67, Testis 6, Penis Urinary System 23, , Bladder (incl. in situ) 10, , Kidney & renal pelvis 13, , Ureter Eye & Orbit Brain & Other Nervous System 5, , Brain 4, , Endocrine System 4, , Thyroid gland 4, , Lymphomas 16, , Hodgkin Lymphoma 2, , Non-Hodgkin Lymphoma 13, , Multiple Myeloma 4, , Leukemias 10, , Acute lymphocytic 3, , Chronic lymphocytic 1, , Acute myeloid 2, , Chronic myeloid 1, Other leukemias 1, Mesothelioma Kaposi Sarcoma 1, Ill-defined & Unknown 9, , Selected tumors (non-invasive) Brain & ONS 1 (benign/borderline) 4, , Breast (in situ) , * Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age and to the 1996 Canadian population standard. - Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. 1 Abbreviations: NOS - Not Otherwise Specified; ONS - Other Nervous System N.B. In areas with small Latino populations, methods to indirectly identify Latinos (like NHIAv2) can overestimate the ethnicity-specific counts of cancer cases. Also, even small errors in Latino population estimates can affect the magnitude of the cancer rates. Data Item 190 used in place of NHIA for MA and RI, see technical notes. UNITED STATES Combined Incidence Hispanic/Latino, All Races III-58

88 UNITED STATES III-59 Combined Incidence Hispanic/Latino, All Races Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Hispanic/Latino, All Races, Males {Page 1 of 4} Kidney & Renal All Sites Prostate Colon & Rectum Lung & Bronchus Pelvis Non-Hodgkin Lymphoma Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 253, , , , , , Alabama Alaska Arizona 7, , California 67, , , , , , CA: Greater Bay Area 9, , CA: Los Angeles 23, , , , , , Colorado 5, , Connecticut 2, Delaware District of Columbia Florida 36, , , , , , Georgia 2, GA: Metropolitan Atlanta 1, Hawaii Idaho Illinois 8, , Indiana 1, Iowa Kansas 1, Kentucky Louisiana 1, Maine Maryland 1, Massachusetts 2, Michigan 2, MI: Metropolitan Detroit Mississippi Missouri

89 UNITED STATES Combined Incidence Hispanic/Latino, All Races III-60 Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Hispanic/Latino, All Races, Males {Page 2 of 4} Kidney & Renal All Sites Prostate Colon & Rectum Lung & Bronchus Pelvis Non-Hodgkin Lymphoma Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Montana Nebraska New Hampshire New Jersey 9, , New Mexico 6, , New York 25, , , , , North Carolina 1, North Dakota Ohio 1, Oklahoma 1, Oregon 1, Pennsylvania 3, Rhode Island South Carolina South Dakota Tennessee Texas 48, , , , , , Utah 1, Vermont Virginia 1, Washington 2, WA: Seattle/Puget Sound 1, West Virginia Wisconsin 1, Wyoming Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: S.E. - Standard Error N.B. In areas with small Latino populations, methods to indirectly identify Latinos (like NHIAv2) can overestimate the ethnicity-specific counts of cancer cases. Also, even small errors in Latino population estimates can affect the magnitude of the cancer rates. Data Item 190 used in place of NHIA for MA and RI, see technical notes.

90 UNITED STATES III-61 Combined Incidence Hispanic/Latino, All Races Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Hispanic/Latino, All Races, Males {Page 3 of 4} Oral Cavity & Liver & IBD 3 Leukemia Bladder Stomach Pharynx Pancreas Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 12, , , , , , Alabama Alaska Arizona California 3, , , , , , CA: Greater Bay Area CA: Los Angeles 1, Colorado Connecticut Delaware District of Columbia Florida 1, , , , Georgia GA: Metropolitan Atlanta Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan MI: Metropolitan Detroit Mississippi Missouri

91 UNITED STATES Combined Incidence Hispanic/Latino, All Races III-62 Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Hispanic/Latino, All Races, Males {Page 4 of 4} Oral Cavity & Liver & IBD 3 Leukemia Bladder Stomach Pharynx Pancreas Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Montana Nebraska New Hampshire New Jersey New Mexico New York 1, North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania Rhode Island South Carolina South Dakota Tennessee Texas 3, , , , , , Utah Vermont Virginia Washington WA: Seattle/Puget Sound West Virginia Wisconsin Wyoming Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: IBD - Intrahepatic Bile Duct; S.E. - Standard Error N.B. In areas with small Latino populations, methods to indirectly identify Latinos (like NHIAv2) can overestimate the ethnicity-specific counts of cancer cases. Also, even small errors in Latino population estimates can affect the magnitude of the cancer rates. Data Item 190 used in place of NHIA for MA and RI, see technical notes.

92 UNITED STATES III-63 Combined Incidence Hispanic/Latina, All Races Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Hispanic/Latina, All Races, Females {Page 1 of 4} All Sites Breast Colon & Rectum Lung & Bronchus Thyroid Uterus Corpus & Uterus NOS 3 Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 261, , , , , , Alabama Alaska Arizona 8, , California 70, , , , , , CA: Greater Bay Area 9, , CA: Los Angeles 25, , , , , , Colorado 5, , Connecticut 3, Delaware District of Columbia Florida 35, , , , , , Georgia 2, GA: Metropolitan Atlanta 1, Hawaii Idaho Illinois 9, , Indiana 1, Iowa Kansas 1, Kentucky Louisiana Maine Maryland 1, Massachusetts 3, Michigan 1, MI: Metropolitan Detroit 1, Mississippi Missouri

93 UNITED STATES Combined Incidence Hispanic/Latina, All Races III-64 Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Hispanic/Latina, All Races, Females {Page 2 of 4} All Sites Breast Colon & Rectum Lung & Bronchus Thyroid Uterus Corpus & Uterus NOS 3 Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Montana Nebraska New Hampshire New Jersey 9, , New Mexico 6, , New York 25, , , , , , North Carolina 2, North Dakota Ohio 1, Oklahoma 1, Oregon 1, Pennsylvania 3, Rhode Island South Carolina South Dakota Tennessee Texas 50, , , , , , Utah 1, Vermont Virginia 2, Washington 2, WA: Seattle/Puget Sound 1, West Virginia Wisconsin 1, Wyoming Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: NOS - Not Otherwise Specified; S.E. - Standard Error N.B. In areas with small Latino populations, methods to indirectly identify Latinos (like NHIAv2) can overestimate the ethnicity-specific counts of cancer cases. Also, even small errors in Latino population estimates can affect the magnitude of the cancer rates. Data Item 190 used in place of NHIA for MA and RI, see technical notes.

94 UNITED STATES III-65 Combined Incidence Hispanic/Latina, All Races Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Hispanic/Latina, All Races, Females {Page 3 of 4} Non-Hodgkin Lymphoma Cervix Kidney & Renal Pelvis Ovary Leukemia Pancreas Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 11, , , , , , Alabama Alaska Arizona California 3, , , , , , CA: Greater Bay Area CA: Los Angeles 1, , Colorado Connecticut Delaware District of Columbia Florida 1, , , Georgia GA: Metropolitan Atlanta Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan MI: Metropolitan Detroit Mississippi Missouri

95 UNITED STATES Combined Incidence Hispanic/Latina, All Races III-66 Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Hispanic/Latina, All Races, Females {Page 4 of 4} Non-Hodgkin Lymphoma Cervix Kidney & Renal Pelvis Ovary Leukemia Pancreas Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Montana Nebraska New Hampshire New Jersey New Mexico New York 1, North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania Rhode Island South Carolina South Dakota Tennessee Texas 2, , , , , , Utah Vermont Virginia Washington WA: Seattle/Puget Sound West Virginia Wisconsin Wyoming Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: S.E. - Standard Error N.B. In areas with small Latino populations, methods to indirectly identify Latinos (like NHIAv2) can overestimate the ethnicity-specific counts of cancer cases. Also, even small errors in Latino population estimates can affect the magnitude of the cancer rates. Data Item 190 used in place of NHIA for MA and RI, see technical notes.

96 NAACCR United States Combined Incidence , The Non-Hispanic White Population Seattle Puget Sound Greater Bay Area Metro Detroit Los Angeles Washington D.C. Metro Atlanta Participating Registries UNITED STATES III-67 Combined Incidence Non-Hispanic White

97 Total Cancer Cases and Average Annual Age-adjusted Cancer Incidence Rates* NAACCR United States Combined, , Non-Hispanic White MALES (NON-HISPANIC WHITE) FEMALES (NON-HISPANIC WHITE) SITES Count Adj. Rate 2000 U.S. S.E. Adj. Rate 1996 Cdn S.E. Count Adj. Rate 2000 U.S. S.E. Adj. Rate 1996 Cdn S.E. All Sites (invasive & in situ bladder) 3,000, ,793, Oral Cavity & Pharynx 102, , Lip 6, , Tongue 31, , Major salivary gland 9, , Floor of mouth 5, , Gum & other mouth 10, , Nasopharynx 3, , Oropharynx 4, , Hypopharynx 6, , Digestive System 533, , Esophagus 50, , Stomach 42, , Small intestine 14, , Colon excl. rectum 185, , Rectum & rectosigmoid 83, , Anus, anal canal & anorectum 8, , Liver 47, , Gallbladder 3, , Pancreas 76, , Respiratory System 493, , Larynx 37, , Lung & bronchus 449, , Bones & Joints 5, , Soft Tissue (incl. heart) 20, , Skin (excl. basal & sq.) 179, , Melanomas of the skin 166, , Breast (excl. in situ) 7, , Female Genital System , Cervix uteri , Uterus Corpus , Uterus, NOS , Ovary , Male Genital System 814, Prostate 779, Testis 30, Penis 4, Urinary System 346, , Bladder (incl. in situ) 218, , Kidney & renal pelvis 120, , Ureter 4, , Eye & Orbit 5, , Brain & Other Nervous System 45, , Brain 43, , Endocrine System 43, , Thyroid gland 39, , Lymphomas 146, , Hodgkin Lymphoma 16, , Non-Hodgkin Lymphoma 130, , Multiple Myeloma 37, , Leukemias 90, , Acute lymphocytic 7, , Chronic lymphocytic 34, , Acute myeloid 25, , Chronic myeloid 10, , Other leukemias 12, , Mesothelioma 10, , Kaposi Sarcoma 2, Ill-defined & Unknown 114, , Selected tumors (non-invasive) Brain & ONS 1 (benign/borderline) 42, , Breast (in situ) , * Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age and to the 1996 Canadian population standard. - Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. 1 Abbreviations: NOS - Not Otherwise Specified; ONS - Other Nervous System N.B. In areas with small Latino populations, methods to indirectly identify Latinos (like NHIAv2) can overestimate the ethnicity-specific counts of cancer cases. Also, even small errors in Latino population estimates can affect the magnitude of the cancer rates. Data Item 190 used in place of NHIA for MA and RI, see technical notes. UNITED STATES Combined Incidence Non-Hispanic White III-68

98 UNITED STATES III-69 Combined Incidence Non-Hispanic White Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Non-Hispanic White, Males {Page 1 of 4} Kidney & Renal All Sites Prostate Colon & Rectum Lung & Bronchus Pelvis Non-Hodgkin Lymphoma Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 3,000, , , , , , Alabama 51, , , , , , Alaska 5, , Arizona 56, , , , , , California 262, , , , , , CA: Greater Bay Area 50, , , , , , CA: Los Angeles 48, , , , , , Colorado 43, , , , , , Connecticut 43, , , , , , Delaware 10, , , District of Columbia 1, Florida 215, , , , , , Georgia 80, , , , , , GA: Metropolitan Atlanta 19, , , , Hawaii 5, , Idaho 18, , , , Illinois 129, , , , , , Indiana 72, , , , , , Iowa 42, , , , , , Kansas 34, , , , , , Kentucky 59, , , , , , Louisiana 44, , , , , , Maine 21, , , , Maryland 48, , , , , , Massachusetts 78, , , , , , Michigan 117, , , , , , MI: Metropolitan Detroit 42, , , , , , Mississippi 28, , , , , , Missouri 69, , , , , ,

99 UNITED STATES Combined Incidence Non-Hispanic White III-70 Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Non-Hispanic White, Males {Page 2 of 4} Kidney & Renal All Sites Prostate Colon & Rectum Lung & Bronchus Pelvis Non-Hodgkin Lymphoma Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Montana 13, , , , Nebraska 21, , , , New Hampshire 19, , , , New Jersey 93, , , , , , New Mexico 14, , , , New York 198, , , , , , North Carolina 97, , , , , , North Dakota 8, , , Ohio 133, , , , , , Oklahoma 40, , , , , , Oregon 45, , , , , , Pennsylvania 169, , , , , , Rhode Island 13, , , , South Carolina 45, , , , , , South Dakota 10, , , , Tennessee 75, , , , , , Texas 172, , , , , , Utah 22, , , , , Vermont 8, , , Virginia 71, , , , , , Washington 75, , , , , , WA: Seattle/Puget Sound 52, , , , , , West Virginia 28, , , , , , Wisconsin 70, , , , , , Wyoming 6, , Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: S.E. - Standard Error N.B. In areas with small Latino populations, methods to indirectly identify Latinos (like NHIAv2) can overestimate the ethnicity-specific counts of cancer cases. Also, even small errors in Latino population estimates can affect the magnitude of the cancer rates. Data Item 190 used in place of NHIA for MA and RI, see technical notes.

100 UNITED STATES III-71 Combined Incidence Non-Hispanic White Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Non-Hispanic White, Males {Page 3 of 4} Oral Cavity & Liver & IBD 3 Leukemia Bladder Stomach Pharynx Pancreas Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 51, , , , , , Alabama , , , , Alaska Arizona 1, , , , , California 5, , , , , , CA: Greater Bay Area 1, , , , , CA: Los Angeles , , , , Colorado , , , , Connecticut , , , , Delaware District of Columbia Florida 4, , , , , , Georgia 1, , , , , GA: Metropolitan Atlanta , Hawaii Idaho , Illinois 2, , , , , , Indiana 1, , , , , Iowa , , , , Kansas , , , Kentucky , , , , Louisiana , , , , Maine , Maryland , , , , Massachusetts 1, , , , , , Michigan 1, , , , , , MI: Metropolitan Detroit , , , , Mississippi , , Missouri 1, , , , ,

101 UNITED STATES Combined Incidence Non-Hispanic White III-72 Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Non-Hispanic White, Males {Page 4 of 4} Oral Cavity & Liver & IBD 3 Leukemia Bladder Stomach Pharynx Pancreas Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Montana Nebraska , New Hampshire , New Jersey 1, , , , , , New Mexico New York 3, , , , , , North Carolina 1, , , , , , North Dakota Ohio 2, , , , , , Oklahoma , , , Oregon , , , , Pennsylvania 2, , , , , , Rhode Island , South Carolina , , , , South Dakota Tennessee 1, , , , , , Texas 3, , , , , , Utah , Vermont Virginia 1, , , , , Washington 1, , , , , , WA: Seattle/Puget Sound 1, , , , , West Virginia , Wisconsin 1, , , , , , Wyoming Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: IBD - Intrahepatic Bile Duct; S.E. - Standard Error N.B. In areas with small Latino populations, methods to indirectly identify Latinos (like NHIAv2) can overestimate the ethnicity-specific counts of cancer cases. Also, even small errors in Latino population estimates can affect the magnitude of the cancer rates. Data Item 190 used in place of NHIA for MA and RI, see technical notes.

102 UNITED STATES III-73 Combined Incidence Non-Hispanic White Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Non-Hispanic White, Females {Page 1 of 4} All Sites Breast Colon & Rectum Lung & Bronchus Thyroid Uterus Corpus & Uterus NOS 3 Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 2,793, , , , , , Alabama 43, , , , , , Alaska 4, , Arizona 53, , , , , , California 242, , , , , , CA: Greater Bay Area 46, , , , , , CA: Los Angeles 46, , , , , , Colorado 42, , , , , , Connecticut 43, , , , , , Delaware 9, , , District of Columbia 1, Florida 187, , , , , , Georgia 71, , , , , , GA: Metropolitan Atlanta 18, , , , Hawaii 4, , Idaho 15, , , , Illinois 125, , , , , , Indiana 70, , , , , , Iowa 39, , , , , , Kansas 30, , , , , , Kentucky 54, , , , , , Louisiana 36, , , , , , Maine 19, , , , , Maryland 47, , , , , , Massachusetts 81, , , , , , Michigan 107, , , , , , MI: Metropolitan Detroit 39, , , , , , Mississippi 23, , , , , Missouri 66, , , , , ,

103 UNITED STATES Combined Incidence Non-Hispanic White III-74 Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Non-Hispanic White, Females {Page 2 of 4} All Sites Breast Colon & Rectum Lung & Bronchus Thyroid Uterus Corpus & Uterus NOS 3 Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Montana 11, , , , Nebraska 20, , , , , New Hampshire 17, , , , , New Jersey 92, , , , , , New Mexico 12, , , , New York 193, , , , , , North Carolina 88, , , , , , North Dakota 7, , Ohio 130, , , , , , Oklahoma 36, , , , , , Oregon 44, , , , , , Pennsylvania 165, , , , , , Rhode Island 13, , , , South Carolina 40, , , , , , South Dakota 9, , , , Tennessee 66, , , , , , Texas 153, , , , , , Utah 18, , , , , , Vermont 8, , , Virginia 67, , , , , , Washington 70, , , , , , WA: Seattle/Puget Sound 49, , , , , , West Virginia 25, , , , , Wisconsin 65, , , , , , Wyoming 5, , Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: NOS - Not Otherwise Specified; S.E. - Standard Error N.B. In areas with small Latino populations, methods to indirectly identify Latinos (like NHIAv2) can overestimate the ethnicity-specific counts of cancer cases. Also, even small errors in Latino population estimates can affect the magnitude of the cancer rates. Data Item 190 used in place of NHIA for MA and RI, see technical notes.

104 UNITED STATES III-75 Combined Incidence Non-Hispanic White Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Non-Hispanic White, Females {Page 3 of 4} Non-Hodgkin Lymphoma Cervix Kidney & Renal Pelvis Ovary Leukemia Pancreas Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 110, , , , , , Alabama 1, , , , , Alaska Arizona 1, , , , , California 9, , , , , , CA: Greater Bay Area 1, , , , CA: Los Angeles 1, , , , Colorado 1, , , , Connecticut 1, , , Delaware District of Columbia Florida 7, , , , , , Georgia 2, , , , , , GA: Metropolitan Atlanta Hawaii Idaho Illinois 4, , , , , , Indiana 2, , , , , , Iowa 1, , , , , Kansas 1, Kentucky 2, , , , , Louisiana 1, , , Maine Maryland 1, , , , , Massachusetts 2, , , , , Michigan 4, , , , , , MI: Metropolitan Detroit 1, , , , Mississippi Missouri 2, , , , , ,

105 UNITED STATES Combined Incidence Non-Hispanic White III-76 Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Non-Hispanic White, Females {Page 4 of 4} Non-Hodgkin Lymphoma Cervix Kidney & Renal Pelvis Ovary Leukemia Pancreas Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Montana Nebraska New Hampshire New Jersey 3, , , , , , New Mexico New York 8, , , , , , North Carolina 3, , , , , , North Dakota Ohio 5, , , , , , Oklahoma 1, , , Oregon 1, , , , Pennsylvania 6, , , , , , Rhode Island South Carolina 1, , , , South Dakota Tennessee 2, , , , , , Texas 6, , , , , , Utah Vermont Virginia 2, , , , , Washington 2, , , , , WA: Seattle/Puget Sound 1, , , , , West Virginia 1, Wisconsin 2, , , , , Wyoming Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: S.E. - Standard Error N.B. In areas with small Latino populations, methods to indirectly identify Latinos (like NHIAv2) can overestimate the ethnicity-specific counts of cancer cases. Also, even small errors in Latino population estimates can affect the magnitude of the cancer rates. Data Item 190 used in place of NHIA for MA and RI, see technical notes.

106 NAACCR United States Combined Incidence , The Non-Hispanic Black Population Seattle Puget Sound Greater Bay Area Metro Detroit Los Angeles Washington D.C. Metro Atlanta Participating Registries UNITED STATES III-77 Combined Incidence Non-Hispanic Black

107 Total Cancer Cases and Average Annual Age-adjusted Cancer Incidence Rates* NAACCR United States Combined, , Non-Hispanic Black MALES (NON-HISPANIC BLACK) FEMALES (NON-HISPANIC BLACK) SITES Count Adj. Rate 2000 U.S. S.E. Adj. Rate 1996 Cdn S.E. Count Adj. Rate 2000 U.S. S.E. Adj. Rate 1996 Cdn S.E. All Sites (invasive & in situ bladder) 408, , Oral Cavity & Pharynx 11, , Lip Tongue 2, , Major salivary gland Floor of mouth Gum & other mouth 1, , Nasopharynx Oropharynx Hypopharynx 1, Digestive System 85, , Esophagus 5, , Stomach 9, , Small intestine 2, , Colon excl. rectum 29, , Rectum & rectosigmoid 11, , Anus, anal canal & anorectum 1, , Liver 11, , Gallbladder , Pancreas 10, , Respiratory System 67, , Larynx 6, , Lung & bronchus 60, , Bones & Joints Soft Tissue (incl. heart) 2, , Skin (excl. basal & sq.) 1, , Melanomas of the skin Breast (excl. in situ) 1, , Female Genital System , Cervix uteri , Uterus Corpus , Uterus, NOS , Ovary , Male Genital System 153, Prostate 151, Testis 1, Penis Urinary System 28, , Bladder (incl. in situ) 11, , Kidney & renal pelvis 17, , Ureter Eye & Orbit Brain & Other Nervous System 3, , Brain 3, , Endocrine System 3, , Thyroid gland 2, , Lymphomas 15, , Hodgkin Lymphoma 2, , Non-Hodgkin Lymphoma 12, , Multiple Myeloma 9, , Leukemias 8, , Acute lymphocytic 1, Chronic lymphocytic 2, , Acute myeloid 2, , Chronic myeloid 1, , Other leukemias 1, , Mesothelioma Kaposi Sarcoma 1, Ill-defined & Unknown 12, , Selected tumors (non-invasive) Brain & ONS 1 (benign/borderline) 5, , Breast (in situ) , * Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age and to the 1996 Canadian population standard. - Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. 1 Abbreviations: NOS - Not Otherwise Specified; ONS - Other Nervous System N.B. In areas with small Latino populations, methods to indirectly identify Latinos (like NHIAv2) can overestimate the ethnicity-specific counts of cancer cases. Also, even small errors in Latino population estimates can affect the magnitude of the cancer rates. Data Item 190 used in place of NHIA for MA and RI, see technical notes. UNITED STATES Combined Incidence Non-Hispanic Black III-78

108 UNITED STATES III-79 Combined Incidence Non-Hispanic Black Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Non-Hispanic Black, Males {Page 1 of 4} Kidney & Renal All Sites Prostate Colon & Rectum Lung & Bronchus Pelvis Non-Hodgkin Lymphoma Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 408, , , , , , Alabama 13, , , , Alaska Arizona 1, California 27, , , , , CA: Greater Bay Area 5, , CA: Los Angeles 10, , , , Colorado 1, Connecticut 3, , Delaware 2, District of Columbia 4, , Florida 27, , , , Georgia 28, , , , , GA: Metropolitan Atlanta 11, , , , Hawaii Idaho Illinois 22, , , , Indiana 5, , , Iowa Kansas 1, Kentucky 3, , Louisiana 17, , , , Maine Maryland 17, , , , Massachusetts 4, , Michigan 17, , , , MI: Metropolitan Detroit 13, , , , Mississippi 12, , , , Missouri 7, , ,

109 UNITED STATES Combined Incidence Non-Hispanic Black III-80 Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Non-Hispanic Black, Males {Page 2 of 4} Kidney & Renal All Sites Prostate Colon & Rectum Lung & Bronchus Pelvis Non-Hodgkin Lymphoma Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Montana Nebraska New Hampshire New Jersey 13, , , , New Mexico New York 34, , , , , , North Carolina 23, , , , , North Dakota Ohio 15, , , , Oklahoma 2, , Oregon Pennsylvania 16, , , , Rhode Island South Carolina 14, , , , South Dakota Tennessee 10, , , , Texas 28, , , , , Utah Vermont Virginia 17, , , , Washington 2, WA: Seattle/Puget Sound 2, West Virginia Wisconsin 3, , Wyoming Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: S.E. - Standard Error N.B. In areas with small Latino populations, methods to indirectly identify Latinos (like NHIAv2) can overestimate the ethnicity-specific counts of cancer cases. Also, even small errors in Latino population estimates can affect the magnitude of the cancer rates. Data Item 190 used in place of NHIA for MA and RI, see technical notes.

110 UNITED STATES III-81 Combined Incidence Non-Hispanic Black Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Non-Hispanic Black, Males {Page 3 of 4} Oral Cavity & Liver & IBD 3 Leukemia Bladder Stomach Pharynx Pancreas Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 12, , , , , , Alabama Alaska Arizona California CA: Greater Bay Area CA: Los Angeles Colorado Connecticut Delaware District of Columbia Florida Georgia GA: Metropolitan Atlanta Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan MI: Metropolitan Detroit Mississippi Missouri

111 UNITED STATES Combined Incidence Non-Hispanic Black III-82 Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Non-Hispanic Black, Males {Page 4 of 4} Oral Cavity & Liver & IBD 3 Leukemia Bladder Stomach Pharynx Pancreas Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Montana Nebraska New Hampshire New Jersey New Mexico New York 1, North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania Rhode Island South Carolina South Dakota Tennessee Texas 1, Utah Vermont Virginia Washington WA: Seattle/Puget Sound West Virginia Wisconsin Wyoming Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: IBD - Intrahepatic Bile Duct; S.E. - Standard Error N.B. In areas with small Latino populations, methods to indirectly identify Latinos (like NHIAv2) can overestimate the ethnicity-specific counts of cancer cases. Also, even small errors in Latino population estimates can affect the magnitude of the cancer rates. Data Item 190 used in place of NHIA for MA and RI, see technical notes.

112 UNITED STATES III-83 Combined Incidence Non-Hispanic Black Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Non-Hispanic Black, Females {Page 1 of 4} All Sites Breast Colon & Rectum Lung & Bronchus Thyroid Uterus Corpus & Uterus NOS 3 Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 372, , , , , , Alabama 12, , , , Alaska Arizona 1, California 23, , , , , CA: Greater Bay Area 5, , CA: Los Angeles 10, , , , Colorado 1, Connecticut 3, , Delaware 1, District of Columbia 4, , Florida 24, , , , , Georgia 25, , , , , GA: Metropolitan Atlanta 11, , , , Hawaii Idaho Illinois 21, , , , , Indiana 5, , Iowa Kansas 1, Kentucky 3, , Louisiana 14, , , , Maine Maryland 17, , , , , Massachusetts 3, , Michigan 15, , , , MI: Metropolitan Detroit 12, , , , Mississippi 10, , , , Missouri 7, , ,

113 UNITED STATES Combined Incidence Non-Hispanic Black III-84 Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Non-Hispanic Black, Females {Page 2 of 4} All Sites Breast Colon & Rectum Lung & Bronchus Thyroid Uterus Corpus & Uterus NOS 3 Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Montana Nebraska New Hampshire New Jersey 12, , , , New Mexico New York 32, , , , , , North Carolina 21, , , , , North Dakota Ohio 14, , , , Oklahoma 2, Oregon Pennsylvania 16, , , , Rhode Island South Carolina 12, , , , South Dakota Tennessee 10, , , , Texas 25, , , , , Utah Vermont Virginia 15, , , , Washington 1, WA: Seattle/Puget Sound 1, West Virginia Wisconsin 2, Wyoming Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: NOS - Not Otherwise Specified; S.E. - Standard Error N.B. In areas with small Latino populations, methods to indirectly identify Latinos (like NHIAv2) can overestimate the ethnicity-specific counts of cancer cases. Also, even small errors in Latino population estimates can affect the magnitude of the cancer rates. Data Item 190 used in place of NHIA for MA and RI, see technical notes.

114 UNITED STATES III-85 Combined Incidence Non-Hispanic Black Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Non-Hispanic Black, Females {Page 3 of 4} Non-Hodgkin Lymphoma Cervix Kidney & Renal Pelvis Ovary Leukemia Pancreas Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 10, , , , , , Alabama Alaska Arizona California CA: Greater Bay Area CA: Los Angeles Colorado Connecticut Delaware District of Columbia Florida Georgia GA: Metropolitan Atlanta Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan MI: Metropolitan Detroit Mississippi Missouri

115 UNITED STATES Combined Incidence Non-Hispanic Black III-86 Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for Commonly Diagnosed Cancers Selected Areas in the NAACCR United States Combined 2, , Non-Hispanic Black, Females {Page 4 of 4} Non-Hodgkin Lymphoma Cervix Kidney & Renal Pelvis Ovary Leukemia Pancreas Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Montana Nebraska New Hampshire New Jersey New Mexico New York 1, , North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania Rhode Island South Carolina South Dakota Tennessee Texas Utah Vermont Virginia Washington WA: Seattle/Puget Sound West Virginia Wisconsin Wyoming Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the U.S. combined. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: S.E. - Standard Error N.B. In areas with small Latino populations, methods to indirectly identify Latinos (like NHIAv2) can overestimate the ethnicity-specific counts of cancer cases. Also, even small errors in Latino population estimates can affect the magnitude of the cancer rates. Data Item 190 used in place of NHIA for MA and RI, see technical notes.

116

117 Race-Specific Population Indicators ( ) Combined Population: All Races White Black American Indian/Alaskan Native Asian/Pacific Islander 63,669, Number of Cases in Combined Cancer Statistics: All Races 320,487 White - Black - American Indian/Alaskan Native - Asian/Pacific Islander - COMBINED CANCER INCIDENCE RATES CANADA Percentage of Canada Population Reflected in the Combined Cancer Statistics: All Races White Black American Indian/Alaskan Native Asian/Pacific Islander 37.9% Race-Specific Population Counts by Year Race All Races 12,399,602 12,569,752 12,754,809 12,907,493 13,037,384 Data Quality Indicators ( ) Indicators (%) Missing Race na na na na na Missing Sex Missing County Missing Age Death Certificate Only Cases Site-Specific Microscopic Confirmation ( ) Cancer Site % Micro. Confirm Cancer Site % Micro. Confirm All Sites 91.1 Prostate 95.1 Oral Cavity & Pharynx 97.8 Testis 98.9 Esophagus 95.3 Bladder (incl. in situ) 96.5 Stomach 95.2 Kidney & Renal Pelvis 84.6 Colon & Rectum 94.8 Brain & Other Nervous System 81.9 Liver 49.4 Thyroid Gland 99.3 Pancreas 59.9 Hodgkin Lymphoma 99.5 Lung & Bronchus 81.5 Non-Hodgkin Lymphoma 96.5 Melanomas of the Skin 99.6 Multiple Myeloma 90.9 Female Breast (excl. in situ) 98.7 Leukemias 93.5 Cervix uteri 98.7 Brain & ONS 1 benign/borderline 59.8 Uterus Corpus & Uterus NOS Breast in situ Ovary Abbreviations: NOS - Not Otherwise Specified; ONS - Other Nervous System CANADA Combined Incidence III-88

118 NAACCR Canadian Combined Incidence , All Races Combined Seattle Puget Sound Greater Bay Area Metro Detroit Los Angeles Washington D.C. Metro Atlanta Participating Registries CANADA III-89 Combined Incidence All Races

119 Total Cancer Cases and Average Annual Age-adjusted Cancer Incidence Rates* NAACCR Canadian Combined, , All Races MALES (ALL RACES) FEMALES (ALL RACES) SITES Count Adj. Rate 2000 U.S. S.E. Adj. Rate 1996 Cdn S.E. Count Adj. Rate 2000 U.S. S.E. Adj. Rate 1996 Cdn S.E. All Sites (invasive & in situ bladder) 168, , Oral Cavity & Pharynx 4, , Lip Tongue 1, Major salivary gland Floor of mouth Gum & other mouth Nasopharynx Oropharynx Hypopharynx Digestive System 37, , Esophagus 2, Stomach 3, , Small intestine Colon excl. rectum 14, , Rectum & rectosigmoid 8, , Anus, anal canal & anorectum Liver 2, Gallbladder Pancreas 3, , Respiratory System 24, , Larynx 1, Lung & bronchus 22, , Bones & Joints Soft Tissue (incl. heart) 1, Skin (excl. basal & sq.) 6, , Melanomas of the skin 6, , Breast (excl. in situ) , Female Genital System , Cervix uteri , Uterus Corpus , Uterus, NOS Ovary , Male Genital System 47, Prostate 45, Testis 1, Penis Urinary System 17, , Bladder (incl. in situ) 11, , Kidney & renal pelvis 5, , Ureter Eye & Orbit Brain & Other Nervous System 2, , Brain 2, , Endocrine System 1, , Thyroid gland 1, , Lymphomas 8, , Hodgkin Lymphoma Non-Hodgkin Lymphoma 7, , Multiple Myeloma 2, , Leukemias 5, , Acute lymphocytic Chronic lymphocytic 2, , Acute myeloid 1, Chronic myeloid Other leukemias Mesothelioma Kaposi Sarcoma Ill-defined & Unknown 5, , Selected tumors (non-invasive) Brain & ONS 1 (benign/borderline) 1, , Breast (in situ) , * Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age and to the 1996 Canadian population standard. - Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. 1 Abbreviations: NOS - Not Otherwise Specified; ONS - Other Nervous System CANADA Combined Incidence All Races III-90

120 CANADA III-91 Combined Incidence All Races Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR Canadian Combined 3, , All Races, Males All Sites Prostate Colon & Rectum Lung & Bronchus Bladder Non-Hodgkin Lymphoma Count Rate S.E. 4 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR Canadian Combined 168, , , , , , Alberta 40, , , , , , British Columbia 59, , , , , , Manitoba 15, , , , , New Brunswick 12, , , , Newfoundland and Labrador 8, , , , Northwest Territory Nova Scotia 15, , , , , Prince Edward Island 2, Saskatchewan 13, , , , Yukon Total Cancer Cases and Average Annual Age-adjusted (1996 Canadian Standard) Cancer Incidence Rates 2 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR Canadian Combined 3, , All Races, Males All Sites Prostate Colon & Rectum Lung & Bronchus Bladder Non-Hodgkin Lymphoma Count Rate S.E. 4 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR Canadian Combined 168, , , , , , Alberta 40, , , , , , British Columbia 59, , , , , , Manitoba 15, , , , , New Brunswick 12, , , , Newfoundland and Labrador 8, , , , Northwest Territory Nova Scotia 15, , , , , Prince Edward Island 2, Saskatchewan 13, , , , Yukon Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the Canadian combined. 2. Rates are per 100,000 and are age-adjusted to the 1996 Canadian population standard. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the Canadian combined. 3. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 4. Abbreviations: S.E. - Standard Error

121 Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR Canadian Combined 3, , All Races, Females All Sites Breast Lung & Bronchus Colon & Rectum Uterus Corpus & Uterus, NOS 4 Non-Hodgkin Lymphoma Count Rate S.E. 4 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR Canadian Combined 151, , , , , , Alberta 36, , , , , , British Columbia 52, , , , , , Manitoba 15, , , , , New Brunswick 10, , , , Newfoundland and Labrador 7, , , Northwest Territory Nova Scotia 13, , , , Prince Edward Island 1, Saskatchewan 12, , , , Yukon CANADA Combined Incidence All Races III-92 Total Cancer Cases and Average Annual Age-adjusted (1996 Canadian Standard) Cancer Incidence Rates 2 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR Canadian Combined 3, , All Races, Females All Sites Breast Lung & Bronchus Colon & Rectum Uterus Corpus & Uterus, NOS 4 Non-Hodgkin Lymphoma Count Rate S.E. 4 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR Canadian Combined 151, , , , , , Alberta 36, , , , , , British Columbia 52, , , , , , Manitoba 15, , , , , New Brunswick 10, , , , Newfoundland and Labrador 7, , , Northwest Territory Nova Scotia 13, , , , Prince Edward Island 1, Saskatchewan 12, , , , Yukon Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the Canadian combined. 2. Rates are per 100,000 and are age-adjusted to the 1996 Canadian population standard. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the Canadian combined. 3. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 4. Abbreviations: NOS - Not Otherwise Specified; S.E. - Standard Error

122

123 Race-Specific Population Indicators ( ) Combined Population: All Races White Black American Indian/Alaskan Native Asian/Pacific Islander 1,542,441, Number of Cases in Combined Cancer Statistics: All Races White 7,746,888 Black - American Indian/Alaskan Native - Asian/Pacific Islander - - Race-Specific Population Counts by Year COMBINED CANCER INCIDENCE RATES NORTH AMERICA Percentage of North America Population Reflected in the Combined Cancer Statistics: All Races White Black American Indian/Alaskan Native Asian/Pacific Islander Race All Races 302,973, ,888, ,663, ,296, ,619, % Data Quality Indicators ( ) Indicators (%) Missing Race na na na na na Missing Sex Missing County Missing Age Death Certificate Only Cases Site-Specific Microscopic Confirmation ( ) Cancer Site % Micro. Confirm Cancer Site % Micro. Confirm All Sites 93.1 Prostate 96.9 Oral Cavity & Pharynx 97.5 Testis 99.0 Esophagus 94.6 Bladder (incl. in situ) 97.7 Stomach 95.9 Kidney & Renal Pelvis 89.8 Colon & Rectum 96.2 Brain & Other Nervous System 84.4 Liver 64.2 Thyroid Gland 99.3 Pancreas 78.9 Hodgkin Lymphoma 98.5 Lung & Bronchus 87.7 Non-Hodgkin Lymphoma 96.3 Melanomas of the Skin 99.0 Multiple Myeloma 87.9 Female Breast (excl. in situ) 98.3 Leukemias 88.3 Cervix uteri 97.4 Brain & ONS 1 benign/borderline 47.7 Uterus Corpus & Uterus NOS Breast in situ Ovary Abbreviations: NOS - Not Otherwise Specified; ONS - Other Nervous System NORTH AMERICA Combined Incidence III-94

124 NAACCR North America Combined Incidence , All Races Combined Seattle Puget Sound Greater Bay Area Metro Detroit Los Angeles Washington D.C. Metro Atlanta Participating Registries NORTH AMERICA III-95 Combined Incidence All Races

125 Total Cancer Cases and Average Annual Age-adjusted Cancer Incidence Rates* NAACCR North America Combined, , All Races MALES (ALL RACES) FEMALES (ALL RACES) SITES Count Adj. Rate 2000 U.S. S.E. Adj. Rate 1996 Cdn S.E. Count Adj. Rate 2000 U.S. S.E. Adj. Rate 1996 Cdn S.E. All Sites (invasive & in situ bladder) 4,006, ,740, Oral Cavity & Pharynx 132, , Lip 7, , Tongue 39, , Major salivary gland 11, , Floor of mouth 7, , Gum & other mouth 14, , Nasopharynx 6, , Oropharynx 6, , Hypopharynx 9, , Digestive System 755, , Esophagus 63, , Stomach 69, , Small intestine 19, , Colon excl. rectum 256, , Rectum & rectosigmoid 119, , Anus, anal canal & anorectum 11, , Liver 80, , Gallbladder 5, , Pancreas 101, , Respiratory System 630, , Larynx 49, , Lung & bronchus 571, , Bones & Joints 8, , Soft Tissue (incl. heart) 28, , Skin (excl. basal & sq.) 199, , Melanomas of the skin 184, , Breast (excl. in situ) 10, ,086, Female Genital System , Cervix uteri , Uterus Corpus , Uterus, NOS , Ovary , Male Genital System 1,152, Prostate 1,103, Testis 40, Penis 6, Urinary System 430, , Bladder (incl. in situ) 259, , Kidney & renal pelvis 162, , Ureter 5, , Eye & Orbit 7, , Brain & Other Nervous System 59, , Brain 56, , Endocrine System 56, , Thyroid gland 50, , Lymphomas 194, , Hodgkin Lymphoma 23, , Non-Hodgkin Lymphoma 170, , Multiple Myeloma 54, , Leukemias 120, , Acute lymphocytic 13, , Chronic lymphocytic 42, , Acute myeloid 33, , Chronic myeloid 15, , Other leukemias 15, , Mesothelioma 12, , Kaposi Sarcoma 5, Ill-defined & Unknown 146, , Selected tumors (non-invasive) Brain & ONS 1 (benign/borderline) 56, , Breast (in situ) 1, , * Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age and to the 1996 Canadian population standard. - Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. 1 Abbreviations: NOS - Not Otherwise Specified; ONS - Other Nervous System NORTH AMERICA Combined Incidence All Races III-96

126 NORTH AMERICA III-97 Combined Incidence All Races Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR North American Combined 2, , All Races, Males All Sites Prostate Lung & Bronchus Colon & Rectum Bladder Melanoma of the Skin Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 3,837, ,058, , , , , Alabama 67, , , , , , Alaska 6, , Arizona 68, , , , , , California 404, , , , , , CA: Greater Bay Area 80, , , , , , CA: Los Angeles 97, , , , , , Colorado 54, , , , , , Connecticut 51, , , , , , Delaware 13, , , , District of Columbia 7, , Florida 284, , , , , , Georgia 113, , , , , , GA: Metropolitan Atlanta 33, , , , , , Hawaii 17, , , , Idaho 19, , , , , , Illinois 166, , , , , , Indiana 80, , , , , , Iowa 44, , , , , , Kansas 38, , , , , , Kentucky 64, , , , , , Louisiana 63, , , , , , Maine 21, , , , , Maryland 70, , , , , , Massachusetts 91, , , , , , Michigan 142, , , , , , MI: Metropolitan Detroit 59, , , , , , Mississippi 41, , , , , , Missouri 78, , , , , , Montana 14, , , , , Nebraska 23, , , , , New Hampshire 19, , , , , , New Jersey 123, , , , , , New Mexico 23, , , , , , New York 271, , , , , ,

127 Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR North American Combined 2, , All Races, Males All Sites Prostate Lung & Bronchus Colon & Rectum Bladder Melanoma of the Skin Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. North Carolina 126, , , , , , North Dakota 9, , , , Ohio 155, , , , , , Oklahoma 49, , , , , , Oregon 50, , , , , , Pennsylvania 196, , , , , , Rhode Island 14, , , , , South Carolina 62, , , , , , South Dakota 10, , , , Tennessee 87, , , , , , Texas 256, , , , , , Utah 24, , , , , , Vermont 9, , , Virginia 94, , , , , , Washington 85, , , , , , WA: Seattle/Puget Sound 61, , , , , , West Virginia 29, , , , , , Wisconsin 77, , , , , , Wyoming 6, , NORTH AMERICA Combined Incidence All Races III-98 NAACCR Canadian Combined 168, , , , , , Alberta 40, , , , , , British Columbia 59, , , , , , Manitoba 15, , , , , New Brunswick 12, , , , Newfoundland and Labrador 8, , , , Northwest Territory Nova Scotia 15, , , , , Prince Edward Island 2, Saskatchewan 13, , , , Yukon NAACCR North American Combined 4,006, ,103, , , , , Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the combined. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: S.E. - Standard Error

128 NORTH AMERICA III-99 Combined Incidence All Races Total Cancer Cases and Average Annual Age-adjusted (1996 Canadian Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR North American Combined 2, , All Races, Males All Sites Prostate Lung & Bronchus Colon & Rectum Bladder Melanoma of the Skin Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 3,837, ,058, , , , , Alabama 67, , , , , , Alaska 6, , Arizona 68, , , , , , California 404, , , , , , CA: Greater Bay Area 80, , , , , , CA: Los Angeles 97, , , , , , Colorado 54, , , , , , Connecticut 51, , , , , , Delaware 13, , , , District of Columbia 7, , Florida 284, , , , , , Georgia 113, , , , , , GA: Metropolitan Atlanta 33, , , , , , Hawaii 17, , , , Idaho 19, , , , , , Illinois 166, , , , , , Indiana 80, , , , , , Iowa 44, , , , , , Kansas 38, , , , , , Kentucky 64, , , , , , Louisiana 63, , , , , , Maine 21, , , , , Maryland 70, , , , , , Massachusetts 91, , , , , , Michigan 142, , , , , , MI: Metropolitan Detroit 59, , , , , , Mississippi 41, , , , , , Missouri 78, , , , , , Montana 14, , , , , Nebraska 23, , , , , New Hampshire 19, , , , , , New Jersey 123, , , , , , New Mexico 23, , , , , , New York 271, , , , , ,

129 Total Cancer Cases and Average Annual Age-adjusted (1996 Canadian Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR North American Combined 2, , All Races, Males All Sites Prostate Lung & Bronchus Colon & Rectum Bladder Melanoma of the Skin Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. North Carolina 126, , , , , , North Dakota 9, , , , Ohio 155, , , , , , Oklahoma 49, , , , , , Oregon 50, , , , , , Pennsylvania 196, , , , , , Rhode Island 14, , , , , South Carolina 62, , , , , , South Dakota 10, , , , Tennessee 87, , , , , , Texas 256, , , , , , Utah 24, , , , , , Vermont 9, , , Virginia 94, , , , , , Washington 85, , , , , , WA: Seattle/Puget Sound 61, , , , , , West Virginia 29, , , , , , Wisconsin 77, , , , , , Wyoming 6, , NORTH AMERICA Combined Incidence All Races III-100 NAACCR Canadian Combined 168, , , , , , Alberta 40, , , , , , British Columbia 59, , , , , , Manitoba 15, , , , , New Brunswick 12, , , , Newfoundland and Labrador 8, , , , Northwest Territory Nova Scotia 15, , , , , Prince Edward Island 2, Saskatchewan 13, , , , Yukon NAACCR North American Combined 4,006, ,103, , , , , Rates are per 100,000 and are age-adjusted to the 1996 Canadian population standard. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the combined. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: S.E. - Standard Error

130 NORTH AMERICA III-101 Combined Incidence All Races Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR North American Combined 2, , All Races, Females All Sites Breast Lung & Bronchus Colon & Rectum Uterus Corpus & Uterus, NOS 3 Thyroid Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 3,588, ,043, , , , , Alabama 57, , , , , , Alaska 6, , Arizona 66, , , , , , California 385, , , , , , CA: Greater Bay Area 76, , , , , , CA: Los Angeles 96, , , , , , Colorado 51, , , , , , Connecticut 51, , , , , , Delaware 12, , , , District of Columbia 7, , Florida 251, , , , , , Georgia 101, , , , , , GA: Metropolitan Atlanta 32, , , , , , Hawaii 16, , , , , Idaho 16, , , , , Illinois 161, , , , , , Indiana 79, , , , , , Iowa 41, , , , , , Kansas 34, , , , , , Kentucky 59, , , , , , Louisiana 52, , , , , , Maine 20, , , , , Maryland 69, , , , , , Massachusetts 92, , , , , , Michigan 128, , , , , , MI: Metropolitan Detroit 54, , , , , , Mississippi 34, , , , , , Missouri 76, , , , , , Montana 12, , , , Nebraska 22, , , , , New Hampshire 18, , , , , New Jersey 120, , , , , , New Mexico 21, , , , , , New York 265, , , , , ,

131 Total Cancer Cases and Average Annual Age-adjusted (2000 U.S. Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR North American Combined 2, , All Races, Females All Sites Breast Lung & Bronchus Colon & Rectum Uterus Corpus & Uterus, NOS 3 Thyroid Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. North Carolina 114, , , , , , North Dakota 8, , Ohio 149, , , , , , Oklahoma 44, , , , , , Oregon 48, , , , , , Pennsylvania 189, , , , , , Rhode Island 15, , , , , South Carolina 55, , , , , , South Dakota 9, , , , Tennessee 78, , , , , , Texas 236, , , , , , Utah 20, , , , , , Vermont 8, , , Virginia 89, , , , , , Washington 80, , , , , , WA: Seattle/Puget Sound 57, , , , , , West Virginia 26, , , , , , Wisconsin 71, , , , , , Wyoming 5, , NORTH AMERICA Combined Incidence All Races III-102 NAACCR Canadian Combined 151, , , , , , Alberta 36, , , , , , British Columbia 52, , , , , , Manitoba 15, , , , , New Brunswick 10, , , , Newfoundland and Labrador 7, , , Northwest Territory Nova Scotia 13, , , , Prince Edward Island 1, Saskatchewan 12, , , , Yukon NAACCR North American Combined 3,740, ,086, , , , , Rates are per 100,000 population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the combined. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: NOS - Not Otherwise Specified; S.E. - Standard Error

132 NORTH AMERICA III-103 Combined Incidence All Races Total Cancer Cases and Average Annual Age-adjusted (1996 Canadian Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR North American Combined 2, , All Races, Females All Sites Breast Lung & Bronchus Colon & Rectum Uterus Corpus & Uterus, NOS 3 Thyroid Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. NAACCR U.S. Combined 3,588, ,043, , , , , Alabama 57, , , , , , Alaska 6, , Arizona 66, , , , , , California 385, , , , , , CA: Greater Bay Area 76, , , , , , CA: Los Angeles 96, , , , , , Colorado 51, , , , , , Connecticut 51, , , , , , Delaware 12, , , , District of Columbia 7, , Florida 251, , , , , , Georgia 101, , , , , , GA: Metropolitan Atlanta 32, , , , , , Hawaii 16, , , , , Idaho 16, , , , , Illinois 161, , , , , , Indiana 79, , , , , , Iowa 41, , , , , , Kansas 34, , , , , , Kentucky 59, , , , , , Louisiana 52, , , , , , Maine 20, , , , , Maryland 69, , , , , , Massachusetts 92, , , , , , Michigan 128, , , , , , MI: Metropolitan Detroit 54, , , , , , Mississippi 34, , , , , , Missouri 76, , , , , , Montana 12, , , , Nebraska 22, , , , , New Hampshire 18, , , , , New Jersey 120, , , , , , New Mexico 21, , , , , , New York 265, , , , , ,

133 Total Cancer Cases and Average Annual Age-adjusted (1996 Canadian Standard) Cancer Incidence Rates 1 for the Five Most Commonly Diagnosed Cancers Selected Areas in the NAACCR North American Combined 2, , All Races, Females All Sites Breast Lung & Bronchus Colon & Rectum Uterus Corpus & Uterus, NOS 3 Thyroid Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. Count Rate S.E. North Carolina 114, , , , , , North Dakota 8, , Ohio 149, , , , , , Oklahoma 44, , , , , , Oregon 48, , , , , , Pennsylvania 189, , , , , , Rhode Island 15, , , , , South Carolina 55, , , , , , South Dakota 9, , , , Tennessee 78, , , , , , Texas 236, , , , , , Utah 20, , , , , , Vermont 8, , , Virginia 89, , , , , , Washington 80, , , , , , WA: Seattle/Puget Sound 57, , , , , , West Virginia 26, , , , , , Wisconsin 71, , , , , , Wyoming 5, , NORTH AMERICA Combined Incidence All Races III-104 NAACCR Canadian Combined 151, , , , , , Alberta 36, , , , , , British Columbia 52, , , , , , Manitoba 15, , , , , New Brunswick 10, , , , Newfoundland and Labrador 7, , , Northwest Territory Nova Scotia 13, , , , Prince Edward Island 1, Saskatchewan 12, , , , Yukon NAACCR North American Combined 3,740, ,086, , , , , Rates are per 100,000 and are age-adjusted to the 1996 Canadian population standard. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for the combined. 2. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. Abbreviations: NOS - Not Otherwise Specified; S.E. - Standard Error

134

135 NAACCR U.S. Combined Pediatric Cancer Incidence Seattle Puget Sound Greater Bay Area Metro Detroit Los Angeles Washington D.C. Metro Atlanta Participating Registries UNITED STATES Pediatric Cancer III-106

136 UNITED STATES III-107 Pediatric Age-specific Rates All Races Total Cancer Cases and Average Annual Age-specific Incidence Rates 1 for Pediatric Cancers NAACCR United States Combined 2, , All Races, Males Ages 0-4 Ages 5-9 Ages Ages Cancer Types Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. All Sites 12, , , , I. Leukemias 4, , , , I(a). Lymphoid leukemias 3, , , , I(b). Acute myeloid leukemias II. Lymphomas & reticuloendothelial neoplasms , , , II(a). Hodgkin lymphomas , II(b, c, e). Non-Hodgkin lymphomas , III. CNS 3 & misc. intracranial & intraspinal neoplasms 2, , , , III(a). Ependymomas and choroids plexus tumor III(b). Astrocytomas III(c). Intracranial and intraspinal embryonal tumors III(d). Other gliomas IV. Neuroblastoma and other peripheral nervous cell tumors 1, IV(a). Neuroblastoma & ganglioneuroblastoma 1, V. Retinoblastoma VI. Renal Tumors VI(a). Nephroblastoma and other nonepithelial renal tumors VII. Hepatic tumors VII(a). Hepatoblastoma VIII. Malignant bone tumors VIII(a). Osteosarcomas VIII(c). Ewing tumor and related sarcomas of bone IX. Soft tissue and other extraosseous sarcomas IX(a). Rhabdomyosarcomas X. Germ cell & trophoblastic tumors & neoplasms of gonads , X(a). Intracranial & intraspinal germ cell tumors X(c). Malignant gonadal germ cell tumors , XI. Other malignant epithelial neoplasms and melanomas , XI(b). Thyroid carcinomas XI(d). Malignant melanomas XII. Other & unspecified malignant neoplasms Rates are per million. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3 Abbreviations: S.E. - Standard Error; CNS - Central Nervous System.

137 Total Cancer Cases and Average Annual Age-specific Incidence Rates 1 for Pediatric Cancers NAACCR United States Combined 2, , All Races, Females UNITED STATES Pediatric Age-specific Rates All Races III-108 Ages 0-4 Ages 5-9 Ages Ages Cancer Types Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. All Sites 10, , , , I. Leukemias 3, , , , I(a). Lymphoid leukemias 2, , I(b). Acute myeloid leukemias II. Lymphomas & reticuloendothelial neoplasms , II(a). Hodgkin lymphomas , II(b, c, e). Non-Hodgkin lymphomas III. CNS 3 & misc. intracranial & intraspinal neoplasms 1, , , , III(a). Ependymomas and choroids plexus tumor III(b). Astrocytomas III(c). Intracranial and intraspinal embryonal tumors III(d). Other gliomas IV. Neuroblastoma and other peripheral nervous cell tumors 1, IV(a). Neuroblastoma & ganglioneuroblastoma 1, V. Retinoblastoma VI. Renal Tumors 1, VI(a). Nephroblastoma and other nonepithelial renal tumors 1, VII. Hepatic tumors VII(a). Hepatoblastoma VIII. Malignant bone tumors VIII(a). Osteosarcomas VIII(c). Ewing tumor and related sarcomas of bone IX. Soft tissue and other extraosseous sarcomas IX(a). Rhabdomyosarcomas X. Germ cell & trophoblastic tumors & neoplasms of gonads X(a). Intracranial & intraspinal germ cell tumors X(c). Malignant gonadal germ cell tumors XI. Other malignant epithelial neoplasms and melanomas , XI(b). Thyroid carcinomas , XI(d). Malignant melanomas XII. Other & unspecified malignant neoplasms Rates are per million. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3 Abbreviations: S.E. - Standard Error; CNS - Central Nervous System.

138 UNITED STATES III-109 Pediatric Age-specific Rates White Total Cancer Cases and Average Annual Age-specific Incidence Rates 1 for Pediatric Cancers NAACCR United States Combined 2, , White, Males Ages 0-4 Ages 5-9 Ages Ages Cancer Types Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. All Sites 9, , , , I. Leukemias 3, , , , I(a). Lymphoid leukemias 2, , , I(b). Acute myeloid leukemias II. Lymphomas & reticuloendothelial neoplasms , , II(a). Hodgkin lymphomas , II(b, c, e). Non-Hodgkin lymphomas III. CNS 3 & misc. intracranial & intraspinal neoplasms 1, , , , III(a). Ependymomas and choroids plexus tumor III(b). Astrocytomas III(c). Intracranial and intraspinal embryonal tumors III(d). Other gliomas IV. Neuroblastoma and other peripheral nervous cell tumors 1, IV(a). Neuroblastoma & ganglioneuroblastoma 1, V. Retinoblastoma VI. Renal Tumors VI(a). Nephroblastoma and other nonepithelial renal tumors VII. Hepatic tumors VII(a). Hepatoblastoma VIII. Malignant bone tumors VIII(a). Osteosarcomas VIII(c). Ewing tumor and related sarcomas of bone IX. Soft tissue and other extraosseous sarcomas IX(a). Rhabdomyosarcomas X. Germ cell & trophoblastic tumors & neoplasms of gonads , X(a). Intracranial & intraspinal germ cell tumors X(c). Malignant gonadal germ cell tumors , XI. Other malignant epithelial neoplasms and melanomas , XI(b). Thyroid carcinomas XI(d). Malignant melanomas XII. Other & unspecified malignant neoplasms Rates are per million. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3 Abbreviations: S.E. - Standard Error; CNS - Central Nervous System.

139 Total Cancer Cases and Average Annual Age-specific Incidence Rates 1 for Pediatric Cancers NAACCR United States Combined 2, , White, Females UNITED STATES Pediatric Age-specific Rates White III-110 Ages 0-4 Ages 5-9 Ages Ages Cancer Types Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. All Sites 8, , , , I. Leukemias 3, , , , I(a). Lymphoid leukemias 2, , I(b). Acute myeloid leukemias II. Lymphomas & reticuloendothelial neoplasms , II(a). Hodgkin lymphomas , II(b, c, e). Non-Hodgkin lymphomas III. CNS 3 & misc. intracranial & intraspinal neoplasms 1, , , III(a). Ependymomas and choroids plexus tumor III(b). Astrocytomas III(c). Intracranial and intraspinal embryonal tumors III(d). Other gliomas IV. Neuroblastoma and other peripheral nervous cell tumors 1, IV(a). Neuroblastoma & ganglioneuroblastoma 1, V. Retinoblastoma VI. Renal Tumors VI(a). Nephroblastoma and other nonepithelial renal tumors VII. Hepatic tumors VII(a). Hepatoblastoma VIII. Malignant bone tumors VIII(a). Osteosarcomas VIII(c). Ewing tumor and related sarcomas of bone IX. Soft tissue and other extraosseous sarcomas IX(a). Rhabdomyosarcomas X. Germ cell & trophoblastic tumors & neoplasms of gonads X(a). Intracranial & intraspinal germ cell tumors X(c). Malignant gonadal germ cell tumors XI. Other malignant epithelial neoplasms and melanomas , XI(b). Thyroid carcinomas , XI(d). Malignant melanomas XII. Other & unspecified malignant neoplasms Rates are per million. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3 Abbreviations: S.E. - Standard Error; CNS - Central Nervous System.

140 UNITED STATES III-111 Pediatric Age-specific Rates Black Total Cancer Cases and Average Annual Age-specific Incidence Rates 1 for Pediatric Cancers NAACCR United States Combined 2, , Black, Males Ages 0-4 Ages 5-9 Ages Ages Cancer Types Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. All Sites 1, , I. Leukemias I(a). Lymphoid leukemias I(b). Acute myeloid leukemias II. Lymphomas & reticuloendothelial neoplasms II(a). Hodgkin lymphomas II(b, c, e). Non-Hodgkin lymphomas III. CNS 3 & misc. intracranial & intraspinal neoplasms III(a). Ependymomas and choroids plexus tumor III(b). Astrocytomas III(c). Intracranial and intraspinal embryonal tumors III(d). Other gliomas IV. Neuroblastoma and other peripheral nervous cell tumors IV(a). Neuroblastoma & ganglioneuroblastoma V. Retinoblastoma VI. Renal Tumors VI(a). Nephroblastoma and other nonepithelial renal tumors VII. Hepatic tumors VII(a). Hepatoblastoma VIII. Malignant bone tumors VIII(a). Osteosarcomas VIII(c). Ewing tumor and related sarcomas of bone IX. Soft tissue and other extraosseous sarcomas IX(a). Rhabdomyosarcomas X. Germ cell & trophoblastic tumors & neoplasms of gonads X(a). Intracranial & intraspinal germ cell tumors X(c). Malignant gonadal germ cell tumors XI. Other malignant epithelial neoplasms and melanomas XI(b). Thyroid carcinomas XI(d). Malignant melanomas XII. Other & unspecified malignant neoplasms Rates are per million. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3 Abbreviations: S.E. - Standard Error; CNS - Central Nervous System.

141 Total Cancer Cases and Average Annual Age-specific Incidence Rates 1 for Pediatric Cancers NAACCR United States Combined 2, , Black, Females UNITED STATES Pediatric Age-specific Rates Black III-112 Ages 0-4 Ages 5-9 Ages Ages Cancer Types Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. All Sites 1, , I. Leukemias I(a). Lymphoid leukemias I(b). Acute myeloid leukemias II. Lymphomas & reticuloendothelial neoplasms II(a). Hodgkin lymphomas II(b, c, e). Non-Hodgkin lymphomas III. CNS 3 & misc. intracranial & intraspinal neoplasms III(a). Ependymomas and choroids plexus tumor III(b). Astrocytomas III(c). Intracranial and intraspinal embryonal tumors III(d). Other gliomas IV. Neuroblastoma and other peripheral nervous cell tumors IV(a). Neuroblastoma & ganglioneuroblastoma V. Retinoblastoma VI. Renal Tumors VI(a). Nephroblastoma and other nonepithelial renal tumors VII. Hepatic tumors VII(a). Hepatoblastoma VIII. Malignant bone tumors VIII(a). Osteosarcomas VIII(c). Ewing tumor and related sarcomas of bone IX. Soft tissue and other extraosseous sarcomas IX(a). Rhabdomyosarcomas X. Germ cell & trophoblastic tumors & neoplasms of gonads X(a). Intracranial & intraspinal germ cell tumors X(c). Malignant gonadal germ cell tumors XI. Other malignant epithelial neoplasms and melanomas XI(b). Thyroid carcinomas XI(d). Malignant melanomas XII. Other & unspecified malignant neoplasms Rates are per million. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3 Abbreviations: S.E. - Standard Error; CNS - Central Nervous System.

142 UNITED STATES III-113 Pediatric Age-specific Rates Asian/Pacific Islander Total Cancer Cases and Average Annual Age-specific Incidence Rates 1 for Pediatric Cancers NAACCR United States Combined 2, , Asian/Pacific Islander, Males Ages 0-4 Ages 5-9 Ages Ages Cancer Types Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. All Sites I. Leukemias I(a). Lymphoid leukemias I(b). Acute myeloid leukemias II. Lymphomas & reticuloendothelial neoplasms II(a). Hodgkin lymphomas II(b, c, e). Non-Hodgkin lymphomas III. CNS 3 & misc. intracranial & intraspinal neoplasms III(a). Ependymomas and choroids plexus tumor III(b). Astrocytomas III(c). Intracranial and intraspinal embryonal tumors III(d). Other gliomas IV. Neuroblastoma and other peripheral nervous cell tumors IV(a). Neuroblastoma & ganglioneuroblastoma V. Retinoblastoma VI. Renal Tumors VI(a). Nephroblastoma and other nonepithelial renal tumors VII. Hepatic tumors VII(a). Hepatoblastoma VIII. Malignant bone tumors VIII(a). Osteosarcomas VIII(c). Ewing tumor and related sarcomas of bone IX. Soft tissue and other extraosseous sarcomas IX(a). Rhabdomyosarcomas X. Germ cell & trophoblastic tumors & neoplasms of gonads X(a). Intracranial & intraspinal germ cell tumors X(c). Malignant gonadal germ cell tumors XI. Other malignant epithelial neoplasms and melanomas XI(b). Thyroid carcinomas XI(d). Malignant melanomas XII. Other & unspecified malignant neoplasms Rates are per million. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3 Abbreviations: S.E. - Standard Error; CNS - Central Nervous System.

143 Total Cancer Cases and Average Annual Age-specific Incidence Rates 1 for Pediatric Cancers NAACCR United States Combined 2, , Asian/Pacific Islander, Females UNITED STATES Pediatric Age-specific Rates Asian/Pacific Islander III-114 Ages 0-4 Ages 5-9 Ages Ages Cancer Types Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. All Sites I. Leukemias I(a). Lymphoid leukemias I(b). Acute myeloid leukemias II. Lymphomas & reticuloendothelial neoplasms II(a). Hodgkin lymphomas II(b, c, e). Non-Hodgkin lymphomas III. CNS 3 & misc. intracranial & intraspinal neoplasms III(a). Ependymomas and choroids plexus tumor III(b). Astrocytomas III(c). Intracranial and intraspinal embryonal tumors III(d). Other gliomas IV. Neuroblastoma and other peripheral nervous cell tumors IV(a). Neuroblastoma & ganglioneuroblastoma V. Retinoblastoma VI. Renal Tumors VI(a). Nephroblastoma and other nonepithelial renal tumors VII. Hepatic tumors VII(a). Hepatoblastoma VIII. Malignant bone tumors VIII(a). Osteosarcomas VIII(c). Ewing tumor and related sarcomas of bone IX. Soft tissue and other extraosseous sarcomas IX(a). Rhabdomyosarcomas X. Germ cell & trophoblastic tumors & neoplasms of gonads X(a). Intracranial & intraspinal germ cell tumors X(c). Malignant gonadal germ cell tumors XI. Other malignant epithelial neoplasms and melanomas XI(b). Thyroid carcinomas XI(d). Malignant melanomas XII. Other & unspecified malignant neoplasms Rates are per million. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3 Abbreviations: S.E. - Standard Error; CNS - Central Nervous System.

144 UNITED STATES III-115 Pediatric Age-specific Rates American Indian/Alaskan Native Total Cancer Cases and Average Annual Age-specific Incidence Rates 1 for Pediatric Cancers NAACCR United States Combined 2, , American Indian/Alaskan Native for CHSDA 3 Counties, Males Ages 0-4 Ages 5-9 Ages Ages Cancer Types Count Rate S.E. 4 Count Rate S.E. Count Rate S.E. Count Rate S.E. All Sites I. Leukemias I(a). Lymphoid leukemias I(b). Acute myeloid leukemias II. Lymphomas & reticuloendothelial neoplasms II(a). Hodgkin lymphomas II(b, c, e). Non-Hodgkin lymphomas III. CNS 4 & misc. intracranial & intraspinal neoplasms III(a). Ependymomas and choroids plexus tumor III(b). Astrocytomas III(c). Intracranial and intraspinal embryonal tumors III(d). Other gliomas IV. Neuroblastoma and other peripheral nervous cell tumors IV(a). Neuroblastoma & ganglioneuroblastoma V. Retinoblastoma VI. Renal Tumors VI(a). Nephroblastoma and other nonepithelial renal tumors VII. Hepatic tumors VII(a). Hepatoblastoma VIII. Malignant bone tumors VIII(a). Osteosarcomas VIII(c). Ewing tumor and related sarcomas of bone IX. Soft tissue and other extraosseous sarcomas IX(a). Rhabdomyosarcomas X. Germ cell & trophoblastic tumors & neoplasms of gonads X(a). Intracranial & intraspinal germ cell tumors X(c). Malignant gonadal germ cell tumors XI. Other malignant epithelial neoplasms and melanomas XI(b). Thyroid carcinomas XI(d). Malignant melanomas XII. Other & unspecified malignant neoplasms Rates are per million. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. Statistics exclude cases diagnosed for KS for all years. 2 See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. CHSDA - Indian Health Services Contract Health Service Delivery Areas (See Appendix G) 4 Abbreviations: S.E. - Standard Error; CNS - Central Nervous System.

145 Total Cancer Cases and Average Annual Age-specific Incidence Rates 1 for Pediatric Cancers NAACCR United States Combined 2, , American Indian/Alaskan Native for CHSDA 3 Counties, Females UNITED STATES Pediatric Age-specific Rates American Indian/Alaskan Native III-116 Ages 0-4 Ages 5-9 Ages Ages Cancer Types Count Rate S.E. 4 Count Rate S.E. Count Rate S.E. Count Rate S.E. All Sites I. Leukemias I(a). Lymphoid leukemias I(b). Acute myeloid leukemias II. Lymphomas & reticuloendothelial neoplasms II(a). Hodgkin lymphomas II(b, c, e). Non-Hodgkin lymphomas III. CNS 4 & misc. intracranial & intraspinal neoplasms III(a). Ependymomas and choroids plexus tumor III(b). Astrocytomas III(c). Intracranial and intraspinal embryonal tumors III(d). Other gliomas IV. Neuroblastoma and other peripheral nervous cell tumors IV(a). Neuroblastoma & ganglioneuroblastoma V. Retinoblastoma VI. Renal Tumors VI(a). Nephroblastoma and other nonepithelial renal tumors VII. Hepatic tumors VII(a). Hepatoblastoma VIII. Malignant bone tumors VIII(a). Osteosarcomas VIII(c). Ewing tumor and related sarcomas of bone IX. Soft tissue and other extraosseous sarcomas IX(a). Rhabdomyosarcomas X. Germ cell & trophoblastic tumors & neoplasms of gonads X(a). Intracranial & intraspinal germ cell tumors X(c). Malignant gonadal germ cell tumors XI. Other malignant epithelial neoplasms and melanomas XI(b). Thyroid carcinomas XI(d). Malignant melanomas XII. Other & unspecified malignant neoplasms Rates are per million. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. Statistics exclude cases diagnosed for KS for all years. 2 See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. CHSDA - Indian Health Services Contract Health Service Delivery Areas (See Appendix G) 4 Abbreviations: S.E. - Standard Error; CNS - Central Nervous System.

146 UNITED STATES III-117 Pediatric Age-specific Rates Hispanic/Latino, All Races Total Cancer Cases and Average Annual Age-specific Incidence Rates 1 for Pediatric Cancers NAACCR United States Combined 2, , Hispanic/Latino, All Races, Males Ages 0-4 Ages 5-9 Ages Ages Cancer Types Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. All Sites 2, , , , I. Leukemias 1, I(a). Lymphoid leukemias I(b). Acute myeloid leukemias II. Lymphomas & reticuloendothelial neoplasms II(a). Hodgkin lymphomas II(b, c, e). Non-Hodgkin lymphomas III. CNS 3 & misc. intracranial & intraspinal neoplasms III(a). Ependymomas and choroids plexus tumor III(b). Astrocytomas III(c). Intracranial and intraspinal embryonal tumors III(d). Other gliomas IV. Neuroblastoma and other peripheral nervous cell tumors IV(a). Neuroblastoma & ganglioneuroblastoma V. Retinoblastoma VI. Renal Tumors VI(a). Nephroblastoma and other nonepithelial renal tumors VII. Hepatic tumors VII(a). Hepatoblastoma VIII. Malignant bone tumors VIII(a). Osteosarcomas VIII(c). Ewing tumor and related sarcomas of bone IX. Soft tissue and other extraosseous sarcomas IX(a). Rhabdomyosarcomas X. Germ cell & trophoblastic tumors & neoplasms of gonads X(a). Intracranial & intraspinal germ cell tumors X(c). Malignant gonadal germ cell tumors XI. Other malignant epithelial neoplasms and melanomas XI(b). Thyroid carcinomas XI(d). Malignant melanomas XII. Other & unspecified malignant neoplasms Rates are per million. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3 Abbreviations: S.E. - Standard Error; CNS - Central Nervous System. N.B. In areas with small Latino populations, methods to indirectly identify Latinos (like NHIAv2) can overestimate the ethnicity-specific counts of cancer cases. Also, even small errors in Latino population estimates can affect the magnitude of the cancer rates. Data Item 190 used in place of NHIA for MA and RI, see technical notes.

147 Total Cancer Cases and Average Annual Age-specific Incidence Rates 1 for Pediatric Cancers United States NAACCR Combined 2, , Hispanic/Latina, All Races, Females UNITED STATES Pediatric Age-specific Rates Hispanic/Latina, All Races III-118 Ages 0-4 Ages 5-9 Ages Ages Cancer Types Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. All Sites 2, , , , I. Leukemias 1, I(a). Lymphoid leukemias I(b). Acute myeloid leukemias II. Lymphomas & reticuloendothelial neoplasms II(a). Hodgkin lymphomas II(b, c, e). Non-Hodgkin lymphomas III. CNS 3 & misc. intracranial & intraspinal neoplasms III(a). Ependymomas and choroids plexus tumor III(b). Astrocytomas III(c). Intracranial and intraspinal embryonal tumors III(d). Other gliomas IV. Neuroblastoma and other peripheral nervous cell tumors IV(a). Neuroblastoma & ganglioneuroblastoma V. Retinoblastoma VI. Renal Tumors VI(a). Nephroblastoma and other nonepithelial renal tumors VII. Hepatic tumors VII(a). Hepatoblastoma VIII. Malignant bone tumors VIII(a). Osteosarcomas VIII(c). Ewing tumor and related sarcomas of bone IX. Soft tissue and other extraosseous sarcomas IX(a). Rhabdomyosarcomas X. Germ cell & trophoblastic tumors & neoplasms of gonads X(a). Intracranial & intraspinal germ cell tumors X(c). Malignant gonadal germ cell tumors XI. Other malignant epithelial neoplasms and melanomas XI(b). Thyroid carcinomas XI(d). Malignant melanomas XII. Other & unspecified malignant neoplasms Rates are per million. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3 Abbreviations: S.E. - Standard Error; CNS - Central Nervous System. N.B. In areas with small Latino populations, methods to indirectly identify Latinos (like NHIAv2) can overestimate the ethnicity-specific counts of cancer cases. Also, even small errors in Latino population estimates can affect the magnitude of the cancer rates. Data Item 190 used in place of NHIA for MA and RI, see technical notes.

148 UNITED STATES III-119 Pediatric Age-specific Rates Non-Hispanic White Total Cancer Cases and Average Annual Age-specific Incidence Rates 1 for Pediatric Cancers NAACCR United States Combined 2, , Non-Hispanic White, Males Ages 0-4 Ages 5-9 Ages Ages Cancer Types Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. All Sites 6, , , , I. Leukemias 2, , , I(a). Lymphoid leukemias 1, , I(b). Acute myeloid leukemias II. Lymphomas & reticuloendothelial neoplasms , II(a). Hodgkin lymphomas , II(b, c, e). Non-Hodgkin lymphomas III. CNS 3 & misc. intracranial & intraspinal neoplasms 1, , III(a). Ependymomas and choroids plexus tumor III(b). Astrocytomas III(c). Intracranial and intraspinal embryonal tumors III(d). Other gliomas IV. Neuroblastoma and other peripheral nervous cell tumors IV(a). Neuroblastoma & ganglioneuroblastoma V. Retinoblastoma VI. Renal Tumors VI(a). Nephroblastoma and other nonepithelial renal tumors VII. Hepatic tumors VII(a). Hepatoblastoma VIII. Malignant bone tumors VIII(a). Osteosarcomas VIII(c). Ewing tumor and related sarcomas of bone IX. Soft tissue and other extraosseous sarcomas IX(a). Rhabdomyosarcomas X. Germ cell & trophoblastic tumors & neoplasms of gonads , X(a). Intracranial & intraspinal germ cell tumors X(c). Malignant gonadal germ cell tumors , XI. Other malignant epithelial neoplasms and melanomas , XI(b). Thyroid carcinomas XI(d). Malignant melanomas XII. Other & unspecified malignant neoplasms Rates are per million. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3 Abbreviations: S.E. - Standard Error; CNS - Central Nervous System. N.B. In areas with small Latino populations, methods to indirectly identify Latinos (like NHIAv2) can overestimate the ethnicity-specific counts of cancer cases. Also, even small errors in Latino population estimates can affect the magnitude of the cancer rates. Data Item 190 used in place of NHIA for MA and RI, see technical notes.

149 Total Cancer Cases and Average Annual Age-specific Incidence Rates 1 for Pediatric Cancers United States NAACCR Combined 2, , Non-Hispanic White, Females UNITED STATES Pediatric Age-specific Rates Non-Hispanic White III-120 Ages 0-4 Ages 5-9 Ages Ages Cancer Types Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. All Sites 6, , , , I. Leukemias 2, , I(a). Lymphoid leukemias 1, I(b). Acute myeloid leukemias II. Lymphomas & reticuloendothelial neoplasms , II(a). Hodgkin lymphomas , II(b, c, e). Non-Hodgkin lymphomas III. CNS 3 & misc. intracranial & intraspinal neoplasms 1, III(a). Ependymomas and choroids plexus tumor III(b). Astrocytomas III(c). Intracranial and intraspinal embryonal tumors III(d). Other gliomas IV. Neuroblastoma and other peripheral nervous cell tumors IV(a). Neuroblastoma & ganglioneuroblastoma V. Retinoblastoma VI. Renal Tumors VI(a). Nephroblastoma and other nonepithelial renal tumors VII. Hepatic tumors VII(a). Hepatoblastoma VIII. Malignant bone tumors VIII(a). Osteosarcomas VIII(c). Ewing tumor and related sarcomas of bone IX. Soft tissue and other extraosseous sarcomas IX(a). Rhabdomyosarcomas X. Germ cell & trophoblastic tumors & neoplasms of gonads X(a). Intracranial & intraspinal germ cell tumors X(c). Malignant gonadal germ cell tumors XI. Other malignant epithelial neoplasms and melanomas , XI(b). Thyroid carcinomas , XI(d). Malignant melanomas XII. Other & unspecified malignant neoplasms Rates are per million. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3 Abbreviations: S.E. - Standard Error; CNS - Central Nervous System. N.B. In areas with small Latino populations, methods to indirectly identify Latinos (like NHIAv2) can overestimate the ethnicity-specific counts of cancer cases. Also, even small errors in Latino population estimates can affect the magnitude of the cancer rates. Data Item 190 used in place of NHIA for MA and RI, see technical notes.

150 UNITED STATES III-121 Pediatric Age-specific Rates Non-Hispanic Black Total Cancer Cases and Average Annual Age-specific Incidence Rates 1 for Pediatric Cancers NAACCR United States Combined 2, , Non-Hispanic Black, Males Ages 0-4 Ages 5-9 Ages Ages Cancer Types Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. All Sites 1, , I. Leukemias I(a). Lymphoid leukemias I(b). Acute myeloid leukemias II. Lymphomas & reticuloendothelial neoplasms II(a). Hodgkin lymphomas II(b, c, e). Non-Hodgkin lymphomas III. CNS 3 & misc. intracranial & intraspinal neoplasms III(a). Ependymomas and choroids plexus tumor III(b). Astrocytomas III(c). Intracranial and intraspinal embryonal tumors III(d). Other gliomas IV. Neuroblastoma and other peripheral nervous cell tumors IV(a). Neuroblastoma & ganglioneuroblastoma V. Retinoblastoma VI. Renal Tumors VI(a). Nephroblastoma and other nonepithelial renal tumors VII. Hepatic tumors VII(a). Hepatoblastoma VIII. Malignant bone tumors VIII(a). Osteosarcomas VIII(c). Ewing tumor and related sarcomas of bone IX. Soft tissue and other extraosseous sarcomas IX(a). Rhabdomyosarcomas X. Germ cell & trophoblastic tumors & neoplasms of gonads X(a). Intracranial & intraspinal germ cell tumors X(c). Malignant gonadal germ cell tumors XI. Other malignant epithelial neoplasms and melanomas XI(b). Thyroid carcinomas XI(d). Malignant melanomas XII. Other & unspecified malignant neoplasms Rates are per million. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3 Abbreviations: S.E. - Standard Error; CNS - Central Nervous System. N.B. In areas with small Latino populations, methods to indirectly identify Latinos (like NHIAv2) can overestimate the ethnicity-specific counts of cancer cases. Also, even small errors in Latino population estimates can affect the magnitude of the cancer rates. Data Item 190 used in place of NHIA for MA and RI, see technical notes.

151 Total Cancer Cases and Average Annual Age-specific Incidence Rates 1 for Pediatric Cancers United States NAACCR Combined 2, , Non-Hispanic Black, Females UNITED STATES Pediatric Age-specific Rates Non-Hispanic Black III-122 Ages 0-4 Ages 5-9 Ages Ages Cancer Types Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. All Sites 1, , I. Leukemias I(a). Lymphoid leukemias I(b). Acute myeloid leukemias II. Lymphomas & reticuloendothelial neoplasms II(a). Hodgkin lymphomas II(b, c, e). Non-Hodgkin lymphomas III. CNS 3 & misc. intracranial & intraspinal neoplasms III(a). Ependymomas and choroids plexus tumor III(b). Astrocytomas III(c). Intracranial and intraspinal embryonal tumors III(d). Other gliomas IV. Neuroblastoma and other peripheral nervous cell tumors IV(a). Neuroblastoma & ganglioneuroblastoma V. Retinoblastoma VI. Renal Tumors VI(a). Nephroblastoma and other nonepithelial renal tumors VII. Hepatic tumors VII(a). Hepatoblastoma VIII. Malignant bone tumors VIII(a). Osteosarcomas VIII(c). Ewing tumor and related sarcomas of bone IX. Soft tissue and other extraosseous sarcomas IX(a). Rhabdomyosarcomas X. Germ cell & trophoblastic tumors & neoplasms of gonads X(a). Intracranial & intraspinal germ cell tumors X(c). Malignant gonadal germ cell tumors XI. Other malignant epithelial neoplasms and melanomas XI(b). Thyroid carcinomas XI(d). Malignant melanomas XII. Other & unspecified malignant neoplasms Rates are per million. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3 Abbreviations: S.E. - Standard Error; CNS - Central Nervous System. N.B. In areas with small Latino populations, methods to indirectly identify Latinos (like NHIAv2) can overestimate the ethnicity-specific counts of cancer cases. Also, even small errors in Latino population estimates can affect the magnitude of the cancer rates. Data Item 190 used in place of NHIA for MA and RI, see technical notes.

152 UNITED STATES III-123 Pediatric Age-adjusted Rates All Races Total Cancer Cases and Average Annual Age-adjusted Incidence Rates 1 for Pediatric Cancers NAACCR United States Combined 2, , All Races, Males Ages 0-14 Ages U.S Cdn 2000 U.S Cdn Cancer Types Count Rate S.E. 3 Rate S.E. Count Rate S.E. Rate S.E. All Sites 25, , I. Leukemias 8, , I(a). Lymphoid leukemias 6, , I(b). Acute myeloid leukemias 1, , II. Lymphomas & reticuloendothelial neoplasms 3, , II(a). Hodgkin lymphomas , II(b, c, e). Non-Hodgkin lymphomas 1, , III. CNS 3 & misc. intracranial & intraspinal neoplasms 5, , III(a). Ependymomas and choroids plexus tumor III(b). Astrocytomas 2, , III(c). Intracranial and intraspinal embryonal tumors 1, , III(d). Other gliomas , IV. Neuroblastoma and other peripheral nervous cell tumors 1, , IV(a). Neuroblastoma & ganglioneuroblastoma 1, , V. Retinoblastoma VI. Renal Tumors 1, , VI(a). Nephroblastoma and other nonepithelial renal tumors 1, , VII. Hepatic tumors VII(a). Hepatoblastoma VIII. Malignant bone tumors 1, , VIII(a). Osteosarcomas , VIII(c). Ewing tumor and related sarcomas of bone IX. Soft tissue and other extraosseous sarcomas 1, , IX(a). Rhabdomyosarcomas , X. Germ cell & trophoblastic tumors & neoplasms of gonads , X(a). Intracranial & intraspinal germ cell tumors X(c). Malignant gonadal germ cell tumors , XI. Other malignant epithelial neoplasms and melanomas , XI(b). Thyroid carcinomas XI(d). Malignant melanomas XII. Other & unspecified malignant neoplasms Rates are per million population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age and to the 1996 Canadian population standard. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. 2 See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3 Abbreviations: S.E. - Standard Error; CNS - Central Nervous System.

153 Total Cancer Cases and Average Annual Age-adjusted Incidence Rates 1 for Pediatric Cancers NAACCR United States Combined 2, , All Races, Females UNITED STATES Pediatric Age-adjusted Rates All Races III-124 Ages 0-14 Ages U.S Cdn 2000 U.S Cdn Cancer Types Count Rate S.E. 3 Rate S.E. Count Rate S.E. Rate S.E. All Sites 22, , I. Leukemias 7, , I(a). Lymphoid leukemias 5, , I(b). Acute myeloid leukemias 1, , II. Lymphomas & reticuloendothelial neoplasms 1, , II(a). Hodgkin lymphomas , II(b, c, e). Non-Hodgkin lymphomas , III. CNS 3 & misc. intracranial & intraspinal neoplasms 4, , III(a). Ependymomas and choroids plexus tumor III(b). Astrocytomas 2, , III(c). Intracranial and intraspinal embryonal tumors , III(d). Other gliomas , IV. Neuroblastoma and other peripheral nervous cell tumors 1, , IV(a). Neuroblastoma & ganglioneuroblastoma 1, , V. Retinoblastoma VI. Renal Tumors 1, , VI(a). Nephroblastoma and other nonepithelial renal tumors 1, , VII. Hepatic tumors VII(a). Hepatoblastoma VIII. Malignant bone tumors , VIII(a). Osteosarcomas VIII(c). Ewing tumor and related sarcomas of bone IX. Soft tissue and other extraosseous sarcomas 1, , IX(a). Rhabdomyosarcomas X. Germ cell & trophoblastic tumors & neoplasms of gonads , X(a). Intracranial & intraspinal germ cell tumors X(c). Malignant gonadal germ cell tumors XI. Other malignant epithelial neoplasms and melanomas 1, , XI(b). Thyroid carcinomas , XI(d). Malignant melanomas , XII. Other & unspecified malignant neoplasms Rates are per million population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age and to the 1996 Canadian population standard. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. 2 See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3 Abbreviations: S.E. - Standard Error; CNS - Central Nervous System.

154 UNITED STATES III-125 Pediatric Age-adjusted Rates White Total Cancer Cases and Average Annual Age-adjusted Incidence Rates 1 for Pediatric Cancers NAACCR United States Combined 2, , White, Males Ages 0-14 Ages U.S Cdn 2000 U.S Cdn Cancer Types Count Rate S.E. 3 Rate S.E. Count Rate S.E. Rate S.E. All Sites 20, , I. Leukemias 6, , I(a). Lymphoid leukemias 5, , I(b). Acute myeloid leukemias , II. Lymphomas & reticuloendothelial neoplasms 2, , II(a). Hodgkin lymphomas , II(b, c, e). Non-Hodgkin lymphomas 1, , III. CNS 3 & misc. intracranial & intraspinal neoplasms 4, , III(a). Ependymomas and choroids plexus tumor III(b). Astrocytomas 2, , III(c). Intracranial and intraspinal embryonal tumors 1, , III(d). Other gliomas IV. Neuroblastoma and other peripheral nervous cell tumors 1, , IV(a). Neuroblastoma & ganglioneuroblastoma 1, , V. Retinoblastoma VI. Renal Tumors VI(a). Nephroblastoma and other nonepithelial renal tumors VII. Hepatic tumors VII(a). Hepatoblastoma VIII. Malignant bone tumors , VIII(a). Osteosarcomas VIII(c). Ewing tumor and related sarcomas of bone IX. Soft tissue and other extraosseous sarcomas 1, , IX(a). Rhabdomyosarcomas X. Germ cell & trophoblastic tumors & neoplasms of gonads , X(a). Intracranial & intraspinal germ cell tumors X(c). Malignant gonadal germ cell tumors , XI. Other malignant epithelial neoplasms and melanomas , XI(b). Thyroid carcinomas XI(d). Malignant melanomas XII. Other & unspecified malignant neoplasms Rates are per million population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age and to the 1996 Canadian population standard. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. 2 See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3 Abbreviations: S.E. - Standard Error; CNS - Central Nervous System.

155 Total Cancer Cases and Average Annual Age-adjusted Incidence Rates 1 for Pediatric Cancers NAACCR United States Combined 2, , White, Females UNITED STATES Pediatric Age-adjusted Rates White III-126 Ages 0-14 Ages U.S Cdn 2000 U.S Cdn Cancer Types Count Rate S.E. 3 Rate S.E. Count Rate S.E. Rate S.E. All Sites 17, , I. Leukemias 5, , I(a). Lymphoid leukemias 4, , I(b). Acute myeloid leukemias , II. Lymphomas & reticuloendothelial neoplasms 1, , II(a). Hodgkin lymphomas , II(b, c, e). Non-Hodgkin lymphomas , III. CNS 3 & misc. intracranial & intraspinal neoplasms 3, , III(a). Ependymomas and choroids plexus tumor III(b). Astrocytomas 1, , III(c). Intracranial and intraspinal embryonal tumors III(d). Other gliomas IV. Neuroblastoma and other peripheral nervous cell tumors 1, , IV(a). Neuroblastoma & ganglioneuroblastoma 1, , V. Retinoblastoma VI. Renal Tumors 1, , VI(a). Nephroblastoma and other nonepithelial renal tumors 1, , VII. Hepatic tumors VII(a). Hepatoblastoma VIII. Malignant bone tumors , VIII(a). Osteosarcomas VIII(c). Ewing tumor and related sarcomas of bone IX. Soft tissue and other extraosseous sarcomas 1, , IX(a). Rhabdomyosarcomas X. Germ cell & trophoblastic tumors & neoplasms of gonads , X(a). Intracranial & intraspinal germ cell tumors X(c). Malignant gonadal germ cell tumors XI. Other malignant epithelial neoplasms and melanomas 1, , XI(b). Thyroid carcinomas , XI(d). Malignant melanomas , XII. Other & unspecified malignant neoplasms Rates are per million population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age and to the 1996 Canadian population standard. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. 2 See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3 Abbreviations: S.E. - Standard Error; CNS - Central Nervous System.

156 UNITED STATES III-127 Pediatric Age-adjusted Rates Black Total Cancer Cases and Average Annual Age-adjusted Incidence Rates 1 for Pediatric Cancers NAACCR United States Combined 2, , Black, Males Ages 0-14 Ages U.S Cdn 2000 U.S Cdn Cancer Types Count Rate S.E. 3 Rate S.E. Count Rate S.E. Rate S.E. All Sites 3, , I. Leukemias , I(a). Lymphoid leukemias I(b). Acute myeloid leukemias II. Lymphomas & reticuloendothelial neoplasms II(a). Hodgkin lymphomas II(b, c, e). Non-Hodgkin lymphomas III. CNS 3 & misc. intracranial & intraspinal neoplasms III(a). Ependymomas and choroids plexus tumor III(b). Astrocytomas III(c). Intracranial and intraspinal embryonal tumors III(d). Other gliomas IV. Neuroblastoma and other peripheral nervous cell tumors IV(a). Neuroblastoma & ganglioneuroblastoma V. Retinoblastoma VI. Renal Tumors VI(a). Nephroblastoma and other nonepithelial renal tumors VII. Hepatic tumors VII(a). Hepatoblastoma VIII. Malignant bone tumors VIII(a). Osteosarcomas VIII(c). Ewing tumor and related sarcomas of bone IX. Soft tissue and other extraosseous sarcomas IX(a). Rhabdomyosarcomas X. Germ cell & trophoblastic tumors & neoplasms of gonads X(a). Intracranial & intraspinal germ cell tumors X(c). Malignant gonadal germ cell tumors XI. Other malignant epithelial neoplasms and melanomas XI(b). Thyroid carcinomas XI(d). Malignant melanomas XII. Other & unspecified malignant neoplasms Rates are per million population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age and to the 1996 Canadian population standard. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. 2 See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3 Abbreviations: S.E. - Standard Error; CNS - Central Nervous System.

157 Total Cancer Cases and Average Annual Age-adjusted Incidence Rates 1 for Pediatric Cancers NAACCR United States Combined 2, , Black, Females UNITED STATES Pediatric Age-adjusted Rates Black III-128 Ages 0-14 Ages U.S Cdn 2000 U.S Cdn Cancer Types Count Rate S.E. 3 Rate S.E. Count Rate S.E. Rate S.E. All Sites 2, , I. Leukemias I(a). Lymphoid leukemias I(b). Acute myeloid leukemias II. Lymphomas & reticuloendothelial neoplasms II(a). Hodgkin lymphomas II(b, c, e). Non-Hodgkin lymphomas III. CNS 3 & misc. intracranial & intraspinal neoplasms III(a). Ependymomas and choroids plexus tumor III(b). Astrocytomas III(c). Intracranial and intraspinal embryonal tumors III(d). Other gliomas IV. Neuroblastoma and other peripheral nervous cell tumors IV(a). Neuroblastoma & ganglioneuroblastoma V. Retinoblastoma VI. Renal Tumors VI(a). Nephroblastoma and other nonepithelial renal tumors VII. Hepatic tumors VII(a). Hepatoblastoma VIII. Malignant bone tumors VIII(a). Osteosarcomas VIII(c). Ewing tumor and related sarcomas of bone IX. Soft tissue and other extraosseous sarcomas IX(a). Rhabdomyosarcomas X. Germ cell & trophoblastic tumors & neoplasms of gonads X(a). Intracranial & intraspinal germ cell tumors X(c). Malignant gonadal germ cell tumors XI. Other malignant epithelial neoplasms and melanomas XI(b). Thyroid carcinomas XI(d). Malignant melanomas XII. Other & unspecified malignant neoplasms Rates are per million population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age and to the 1996 Canadian population standard. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. 2 See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3 Abbreviations: S.E. - Standard Error; CNS - Central Nervous System.

158 UNITED STATES III-129 Pediatric Age-adjusted Rates Asian/Pacific Islander Total Cancer Cases and Average Annual Age-adjusted Incidence Rates 1 for Pediatric Cancers NAACCR United States Combined 2, , Asian/Pacific Islander, Males Ages 0-14 Ages U.S Cdn 2000 U.S Cdn Cancer Types Count Rate S.E. 3 Rate S.E. Count Rate S.E. Rate S.E. All Sites 1, , I. Leukemias I(a). Lymphoid leukemias I(b). Acute myeloid leukemias II. Lymphomas & reticuloendothelial neoplasms II(a). Hodgkin lymphomas II(b, c, e). Non-Hodgkin lymphomas III. CNS 3 & misc. intracranial & intraspinal neoplasms III(a). Ependymomas and choroids plexus tumor III(b). Astrocytomas III(c). Intracranial and intraspinal embryonal tumors III(d). Other gliomas IV. Neuroblastoma and other peripheral nervous cell tumors IV(a). Neuroblastoma & ganglioneuroblastoma V. Retinoblastoma VI. Renal Tumors VI(a). Nephroblastoma and other nonepithelial renal tumors VII. Hepatic tumors VII(a). Hepatoblastoma VIII. Malignant bone tumors VIII(a). Osteosarcomas VIII(c). Ewing tumor and related sarcomas of bone IX. Soft tissue and other extraosseous sarcomas IX(a). Rhabdomyosarcomas X. Germ cell & trophoblastic tumors & neoplasms of gonads X(a). Intracranial & intraspinal germ cell tumors X(c). Malignant gonadal germ cell tumors XI. Other malignant epithelial neoplasms and melanomas XI(b). Thyroid carcinomas XI(d). Malignant melanomas XII. Other & unspecified malignant neoplasms Rates are per million population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age and to the 1996 Canadian population standard. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. 2 See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3 Abbreviations: S.E. - Standard Error; CNS - Central Nervous System.

159 Total Cancer Cases and Average Annual Age-adjusted Incidence Rates 1 for Pediatric Cancers NAACCR United States Combined 2, , Asian/Pacific Islander, Females UNITED STATES Pediatric Age-adjusted Rates Asian/Pacific Islander III-130 Ages 0-14 Ages U.S Cdn 2000 U.S Cdn Cancer Types Count Rate S.E. 3 Rate S.E. Count Rate S.E. Rate S.E. All Sites , I. Leukemias I(a). Lymphoid leukemias I(b). Acute myeloid leukemias II. Lymphomas & reticuloendothelial neoplasms II(a). Hodgkin lymphomas II(b, c, e). Non-Hodgkin lymphomas III. CNS 3 & misc. intracranial & intraspinal neoplasms III(a). Ependymomas and choroids plexus tumor III(b). Astrocytomas III(c). Intracranial and intraspinal embryonal tumors III(d). Other gliomas IV. Neuroblastoma and other peripheral nervous cell tumors IV(a). Neuroblastoma & ganglioneuroblastoma V. Retinoblastoma VI. Renal Tumors VI(a). Nephroblastoma and other nonepithelial renal tumors VII. Hepatic tumors VII(a). Hepatoblastoma VIII. Malignant bone tumors VIII(a). Osteosarcomas VIII(c). Ewing tumor and related sarcomas of bone IX. Soft tissue and other extraosseous sarcomas IX(a). Rhabdomyosarcomas X. Germ cell & trophoblastic tumors & neoplasms of gonads X(a). Intracranial & intraspinal germ cell tumors X(c). Malignant gonadal germ cell tumors XI. Other malignant epithelial neoplasms and melanomas XI(b). Thyroid carcinomas XI(d). Malignant melanomas XII. Other & unspecified malignant neoplasms Rates are per million population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age and to the 1996 Canadian population standard. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. 2 See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3 Abbreviations: S.E. - Standard Error; CNS - Central Nervous System.

160 UNITED STATES III-131 Pediatric Age-adjusted Rates American Indian/Alaskan Native Total Cancer Cases and Average Annual Age-adjusted Incidence Rates 1 for Pediatric Cancers NAACCR United States Combined 2, , American Indian/Alaskan Native for CHSDA 3 Counties, Males Ages 0-14 Ages U.S Cdn 2000 U.S Cdn Cancer Types Count Rate S.E. 4 Rate S.E. Count Rate S.E. Rate S.E. All Sites I. Leukemias I(a). Lymphoid leukemias I(b). Acute myeloid leukemias II. Lymphomas & reticuloendothelial neoplasms II(a). Hodgkin lymphomas II(b, c, e). Non-Hodgkin lymphomas III. CNS 4 & misc. intracranial & intraspinal neoplasms III(a). Ependymomas and choroids plexus tumor III(b). Astrocytomas III(c). Intracranial and intraspinal embryonal tumors III(d). Other gliomas IV. Neuroblastoma and other peripheral nervous cell tumors IV(a). Neuroblastoma & ganglioneuroblastoma V. Retinoblastoma VI. Renal Tumors VI(a). Nephroblastoma and other nonepithelial renal tumors VII. Hepatic tumors VII(a). Hepatoblastoma VIII. Malignant bone tumors VIII(a). Osteosarcomas VIII(c). Ewing tumor and related sarcomas of bone IX. Soft tissue and other extraosseous sarcomas IX(a). Rhabdomyosarcomas X. Germ cell & trophoblastic tumors & neoplasms of gonads X(a). Intracranial & intraspinal germ cell tumors X(c). Malignant gonadal germ cell tumors XI. Other malignant epithelial neoplasms and melanomas XI(b). Thyroid carcinomas XI(d). Malignant melanomas XII. Other & unspecified malignant neoplasms Rates are per million population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age and to the 1996 Canadian population standard. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. Statistics exclude cases diagnosed for KS for all years. 2 See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. CHSDA - Indian Health Services Contract Health Service Delivery Areas (See Appendix G) 4 Abbreviations: S.E. - Standard Error; CNS - Central Nervous System.

161 Total Cancer Cases and Average Annual Age-adjusted Incidence Rates 1 for Pediatric Cancers NAACCR United States Combined 2, , American Indian/Alaskan Native for CHSDA 3 Counties, Females UNITED STATES Pediatric Age-adjusted Rates American Indian/Alaskan Native III-132 Ages 0-14 Ages U.S Cdn 2000 U.S Cdn Cancer Types Count Rate S.E. 4 Rate S.E. Count Rate S.E. Rate S.E. All Sites I. Leukemias I(a). Lymphoid leukemias I(b). Acute myeloid leukemias II. Lymphomas & reticuloendothelial neoplasms II(a). Hodgkin lymphomas II(b, c, e). Non-Hodgkin lymphomas III. CNS 4 & misc. intracranial & intraspinal neoplasms III(a). Ependymomas and choroids plexus tumor III(b). Astrocytomas III(c). Intracranial and intraspinal embryonal tumors III(d). Other gliomas IV. Neuroblastoma and other peripheral nervous cell tumors IV(a). Neuroblastoma & ganglioneuroblastoma V. Retinoblastoma VI. Renal Tumors VI(a). Nephroblastoma and other nonepithelial renal tumors VII. Hepatic tumors VII(a). Hepatoblastoma VIII. Malignant bone tumors VIII(a). Osteosarcomas VIII(c). Ewing tumor and related sarcomas of bone IX. Soft tissue and other extraosseous sarcomas IX(a). Rhabdomyosarcomas X. Germ cell & trophoblastic tumors & neoplasms of gonads X(a). Intracranial & intraspinal germ cell tumors X(c). Malignant gonadal germ cell tumors XI. Other malignant epithelial neoplasms and melanomas XI(b). Thyroid carcinomas XI(d). Malignant melanomas XII. Other & unspecified malignant neoplasms Rates are per million population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age and to the 1996 Canadian population standard. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. Statistics exclude cases diagnosed for KS for all years. 2 See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3. CHSDA - Indian Health Services Contract Health Service Delivery Areas (See Appendix G) 4 Abbreviations: S.E. - Standard Error; CNS - Central Nervous System.

162 UNITED STATES III-133 Pediatric Age-adjusted Rates Hispanic/Latino, All Races Total Cancer Cases and Average Annual Age-adjusted Incidence Rates 1 for Pediatric Cancers NAACCR United States Combined 2, , Hispanic/Latino, All Races, Males Ages 0-14 Ages U.S Cdn 2000 U.S Cdn Cancer Types Count Rate S.E. 3 Rate S.E. Count Rate S.E. Rate S.E. All Sites 6, , I. Leukemias 2, , I(a). Lymphoid leukemias 1, , I(b). Acute myeloid leukemias II. Lymphomas & reticuloendothelial neoplasms , II(a). Hodgkin lymphomas II(b, c, e). Non-Hodgkin lymphomas III. CNS 3 & misc. intracranial & intraspinal neoplasms , III(a). Ependymomas and choroids plexus tumor III(b). Astrocytomas III(c). Intracranial and intraspinal embryonal tumors III(d). Other gliomas IV. Neuroblastoma and other peripheral nervous cell tumors IV(a). Neuroblastoma & ganglioneuroblastoma V. Retinoblastoma VI. Renal Tumors VI(a). Nephroblastoma and other nonepithelial renal tumors VII. Hepatic tumors VII(a). Hepatoblastoma VIII. Malignant bone tumors VIII(a). Osteosarcomas VIII(c). Ewing tumor and related sarcomas of bone IX. Soft tissue and other extraosseous sarcomas IX(a). Rhabdomyosarcomas X. Germ cell & trophoblastic tumors & neoplasms of gonads X(a). Intracranial & intraspinal germ cell tumors X(c). Malignant gonadal germ cell tumors XI. Other malignant epithelial neoplasms and melanomas XI(b). Thyroid carcinomas XI(d). Malignant melanomas XII. Other & unspecified malignant neoplasms Rates are per million population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age and to the 1996 Canadian population standard. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. 2 See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3 Abbreviations: S.E. - Standard Error; CNS - Central Nervous System. N.B. In areas with small Latino populations, methods to indirectly identify Latinos (like NHIAv2) can overestimate the ethnicity-specific counts of cancer cases. Also, even small errors in Latino population estimates can affect the magnitude of the cancer rates. Data Item 190 used in place of NHIA for MA and RI, see technical notes.

163 Total Cancer Cases and Average Annual Age-adjusted Incidence Rates 1 for Pediatric Cancers NAACCR United States Combined 2, , Hispanic/Latina, All Races, Females UNITED STATES Pediatric Age-adjusted Rates Hispanic/Latina, All Races III-134 Ages 0-14 Ages U.S Cdn 2000 U.S Cdn Cancer Types Count Rate S.E. 3 Rate S.E. Count Rate S.E. Rate S.E. All Sites 5, , I. Leukemias 2, , I(a). Lymphoid leukemias 1, , I(b). Acute myeloid leukemias II. Lymphomas & reticuloendothelial neoplasms II(a). Hodgkin lymphomas II(b, c, e). Non-Hodgkin lymphomas III. CNS 3 & misc. intracranial & intraspinal neoplasms , III(a). Ependymomas and choroids plexus tumor III(b). Astrocytomas III(c). Intracranial and intraspinal embryonal tumors III(d). Other gliomas IV. Neuroblastoma and other peripheral nervous cell tumors IV(a). Neuroblastoma & ganglioneuroblastoma V. Retinoblastoma VI. Renal Tumors VI(a). Nephroblastoma and other nonepithelial renal tumors VII. Hepatic tumors VII(a). Hepatoblastoma VIII. Malignant bone tumors VIII(a). Osteosarcomas VIII(c). Ewing tumor and related sarcomas of bone IX. Soft tissue and other extraosseous sarcomas IX(a). Rhabdomyosarcomas X. Germ cell & trophoblastic tumors & neoplasms of gonads X(a). Intracranial & intraspinal germ cell tumors X(c). Malignant gonadal germ cell tumors XI. Other malignant epithelial neoplasms and melanomas XI(b). Thyroid carcinomas XI(d). Malignant melanomas XII. Other & unspecified malignant neoplasms Rates are per million population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age and to the 1996 Canadian population standard. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. 2 See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3 Abbreviations: S.E. - Standard Error; CNS - Central Nervous System. N.B. In areas with small Latino populations, methods to indirectly identify Latinos (like NHIAv2) can overestimate the ethnicity-specific counts of cancer cases. Also, even small errors in Latino population estimates can affect the magnitude of the cancer rates. Data Item 190 used in place of NHIA for MA and RI, see technical notes.

164 UNITED STATES III-135 Pediatric Age-adjusted Rates Non-Hispanic White Total Cancer Cases and Average Annual Age-adjusted Incidence Rates 1 for Pediatric Cancers NAACCR United States Combined 2, , Non-Hispanic White, Males Ages 0-14 Ages U.S Cdn 2000 U.S Cdn Cancer Types Count Rate S.E. 3 Rate S.E. Count Rate S.E. Rate S.E. All Sites 14, , I. Leukemias 4, , I(a). Lymphoid leukemias 3, , I(b). Acute myeloid leukemias II. Lymphomas & reticuloendothelial neoplasms 1, , II(a). Hodgkin lymphomas , II(b, c, e). Non-Hodgkin lymphomas 1, , III. CNS 3 & misc. intracranial & intraspinal neoplasms 3, , III(a). Ependymomas and choroids plexus tumor III(b). Astrocytomas 1, , III(c). Intracranial and intraspinal embryonal tumors III(d). Other gliomas IV. Neuroblastoma and other peripheral nervous cell tumors 1, , IV(a). Neuroblastoma & ganglioneuroblastoma 1, , V. Retinoblastoma VI. Renal Tumors VI(a). Nephroblastoma and other nonepithelial renal tumors VII. Hepatic tumors VII(a). Hepatoblastoma VIII. Malignant bone tumors , VIII(a). Osteosarcomas VIII(c). Ewing tumor and related sarcomas of bone IX. Soft tissue and other extraosseous sarcomas , IX(a). Rhabdomyosarcomas X. Germ cell & trophoblastic tumors & neoplasms of gonads , X(a). Intracranial & intraspinal germ cell tumors X(c). Malignant gonadal germ cell tumors , XI. Other malignant epithelial neoplasms and melanomas , XI(b). Thyroid carcinomas XI(d). Malignant melanomas XII. Other & unspecified malignant neoplasms Rates are per million population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age and to the 1996 Canadian population standard. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. 2 See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3 Abbreviations: S.E. - Standard Error; CNS - Central Nervous System. N.B. In areas with small Latino populations, methods to indirectly identify Latinos (like NHIAv2) can overestimate the ethnicity-specific counts of cancer cases. Also, even small errors in Latino population estimates can affect the magnitude of the cancer rates. Data Item 190 used in place of NHIA for MA and RI, see technical notes.

165 Total Cancer Cases and Average Annual Age-adjusted Incidence Rates 1 for Pediatric Cancers NAACCR United States Combined 2, , Non-Hispanic White, Females UNITED STATES Pediatric Age-adjusted Rates Non-Hispanic White III-136 Ages 0-14 Ages U.S Cdn 2000 U.S Cdn Cancer Types Count Rate S.E. 3 Rate S.E. Count Rate S.E. Rate S.E. All Sites 12, , I. Leukemias 3, , I(a). Lymphoid leukemias 3, , I(b). Acute myeloid leukemias II. Lymphomas & reticuloendothelial neoplasms 1, , II(a). Hodgkin lymphomas , II(b, c, e). Non-Hodgkin lymphomas III. CNS 3 & misc. intracranial & intraspinal neoplasms 2, , III(a). Ependymomas and choroids plexus tumor III(b). Astrocytomas 1, , III(c). Intracranial and intraspinal embryonal tumors III(d). Other gliomas IV. Neuroblastoma and other peripheral nervous cell tumors IV(a). Neuroblastoma & ganglioneuroblastoma V. Retinoblastoma VI. Renal Tumors VI(a). Nephroblastoma and other nonepithelial renal tumors VII. Hepatic tumors VII(a). Hepatoblastoma VIII. Malignant bone tumors VIII(a). Osteosarcomas VIII(c). Ewing tumor and related sarcomas of bone IX. Soft tissue and other extraosseous sarcomas , IX(a). Rhabdomyosarcomas X. Germ cell & trophoblastic tumors & neoplasms of gonads X(a). Intracranial & intraspinal germ cell tumors X(c). Malignant gonadal germ cell tumors XI. Other malignant epithelial neoplasms and melanomas , XI(b). Thyroid carcinomas , XI(d). Malignant melanomas XII. Other & unspecified malignant neoplasms Rates are per million population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age and to the 1996 Canadian population standard. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. 2 See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3 Abbreviations: S.E. - Standard Error; CNS - Central Nervous System. N.B. In areas with small Latino populations, methods to indirectly identify Latinos (like NHIAv2) can overestimate the ethnicity-specific counts of cancer cases. Also, even small errors in Latino population estimates can affect the magnitude of the cancer rates. Data Item 190 used in place of NHIA for MA and RI, see technical notes.

166 UNITED STATES III-137 Pediatric Age-adjusted Rates Non-Hispanic Black Total Cancer Cases and Average Annual Age-adjusted Incidence Rates 1 for Pediatric Cancers NAACCR United States Combined 2, , Non-Hispanic Black, Males Ages 0-14 Ages U.S Cdn 2000 U.S Cdn Cancer Types Count Rate S.E. 3 Rate S.E. Count Rate S.E. Rate S.E. All Sites 3, , I. Leukemias , I(a). Lymphoid leukemias I(b). Acute myeloid leukemias II. Lymphomas & reticuloendothelial neoplasms II(a). Hodgkin lymphomas II(b, c, e). Non-Hodgkin lymphomas III. CNS 3 & misc. intracranial & intraspinal neoplasms III(a). Ependymomas and choroids plexus tumor III(b). Astrocytomas III(c). Intracranial and intraspinal embryonal tumors III(d). Other gliomas IV. Neuroblastoma and other peripheral nervous cell tumors IV(a). Neuroblastoma & ganglioneuroblastoma V. Retinoblastoma VI. Renal Tumors VI(a). Nephroblastoma and other nonepithelial renal tumors VII. Hepatic tumors VII(a). Hepatoblastoma VIII. Malignant bone tumors VIII(a). Osteosarcomas VIII(c). Ewing tumor and related sarcomas of bone IX. Soft tissue and other extraosseous sarcomas IX(a). Rhabdomyosarcomas X. Germ cell & trophoblastic tumors & neoplasms of gonads X(a). Intracranial & intraspinal germ cell tumors X(c). Malignant gonadal germ cell tumors XI. Other malignant epithelial neoplasms and melanomas XI(b). Thyroid carcinomas XI(d). Malignant melanomas XII. Other & unspecified malignant neoplasms Rates are per million population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age and to the 1996 Canadian population standard. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. 2 See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3 Abbreviations: S.E. - Standard Error; CNS - Central Nervous System. N.B. In areas with small Latino populations, methods to indirectly identify Latinos (like NHIAv2) can overestimate the ethnicity-specific counts of cancer cases. Also, even small errors in Latino population estimates can affect the magnitude of the cancer rates. Data Item 190 used in place of NHIA for MA and RI, see technical notes.

167 Total Cancer Cases and Average Annual Age-adjusted Incidence Rates 1 for Pediatric Cancers NAACCR United States Combined 2, , Non-Hispanic Black, Females UNITED STATES Pediatric Age-adjusted Rates Non-Hispanic Black III-138 Ages 0-14 Ages U.S Cdn 2000 U.S Cdn Cancer Types Count Rate S.E. 3 Rate S.E. Count Rate S.E. Rate S.E. All Sites 2, , I. Leukemias I(a). Lymphoid leukemias I(b). Acute myeloid leukemias II. Lymphomas & reticuloendothelial neoplasms II(a). Hodgkin lymphomas II(b, c, e). Non-Hodgkin lymphomas III. CNS 3 & misc. intracranial & intraspinal neoplasms III(a). Ependymomas and choroids plexus tumor III(b). Astrocytomas III(c). Intracranial and intraspinal embryonal tumors III(d). Other gliomas IV. Neuroblastoma and other peripheral nervous cell tumors IV(a). Neuroblastoma & ganglioneuroblastoma V. Retinoblastoma VI. Renal Tumors VI(a). Nephroblastoma and other nonepithelial renal tumors VII. Hepatic tumors VII(a). Hepatoblastoma VIII. Malignant bone tumors VIII(a). Osteosarcomas VIII(c). Ewing tumor and related sarcomas of bone IX. Soft tissue and other extraosseous sarcomas IX(a). Rhabdomyosarcomas X. Germ cell & trophoblastic tumors & neoplasms of gonads X(a). Intracranial & intraspinal germ cell tumors X(c). Malignant gonadal germ cell tumors XI. Other malignant epithelial neoplasms and melanomas XI(b). Thyroid carcinomas XI(d). Malignant melanomas XII. Other & unspecified malignant neoplasms Rates are per million population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age and to the 1996 Canadian population standard. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. 2 See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3 Abbreviations: S.E. - Standard Error; CNS - Central Nervous System. N.B. In areas with small Latino populations, methods to indirectly identify Latinos (like NHIAv2) can overestimate the ethnicity-specific counts of cancer cases. Also, even small errors in Latino population estimates can affect the magnitude of the cancer rates. Data Item 190 used in place of NHIA for MA and RI, see technical notes.

168

169 NAACCR Canadian Combined Pediatric Cancer Incidence Seattle Puget Sound Greater Bay Area Metro Detroit Los Angeles Washington D.C. Metro Atlanta Participating Registries CANADA Pediatric Cancer III-140

170 CANADA III-141 Pediatric Age-specific Rates All Races Total Cancer Cases and Average Annual Age-specific Incidence Rates 1 for Pediatric Cancers NAACCR Canadian Combined 2, , All Races, Males Ages 0-4 Ages 5-9 Ages Ages Cancer Types Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. All Sites I. Leukemias I(a). Lymphoid leukemias I(b). Acute myeloid leukemias II. Lymphomas & reticuloendothelial neoplasms II(a). Hodgkin lymphomas II(b, c, e). Non-Hodgkin lymphomas III. CNS 3 & misc. intracranial & intraspinal neoplasms III(a). Ependymomas and choroids plexus tumor III(b). Astrocytomas III(c). Intracranial and intraspinal embryonal tumors III(d). Other gliomas IV. Neuroblastoma and other peripheral nervous cell tumors IV(a). Neuroblastoma & ganglioneuroblastoma V. Retinoblastoma VI. Renal Tumors VI(a). Nephroblastoma and other nonepithelial renal tumors VII. Hepatic tumors VII(a). Hepatoblastoma VIII. Malignant bone tumors VIII(a). Osteosarcomas VIII(c). Ewing tumor and related sarcomas of bone IX. Soft tissue and other extraosseous sarcomas IX(a). Rhabdomyosarcomas X. Germ cell & trophoblastic tumors & neoplasms of gonads X(a). Intracranial & intraspinal germ cell tumors X(c). Malignant gonadal germ cell tumors XI. Other malignant epithelial neoplasms and melanomas XI(b). Thyroid carcinomas XI(d). Malignant melanomas XII. Other & unspecified malignant neoplasms Rates are per million. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. 2 See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3 Abbreviations: S.E. - Standard Error; CNS - Central Nervous System.

171 Total Cancer Cases and Average Annual Age-specific Incidence Rates 1 for Pediatric Cancers NAACCR Canadian Combined 2, , All Races, Females CANADA Pediatric Age-specific Rates All Races III-142 Ages 0-4 Ages 5-9 Ages Ages Cancer Types Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. All Sites I. Leukemias I(a). Lymphoid leukemias I(b). Acute myeloid leukemias II. Lymphomas & reticuloendothelial neoplasms II(a). Hodgkin lymphomas II(b, c, e). Non-Hodgkin lymphomas III. CNS 3 & misc. intracranial & intraspinal neoplasms III(a). Ependymomas and choroids plexus tumor III(b). Astrocytomas III(c). Intracranial and intraspinal embryonal tumors III(d). Other gliomas IV. Neuroblastoma and other peripheral nervous cell tumors IV(a). Neuroblastoma & ganglioneuroblastoma V. Retinoblastoma VI. Renal Tumors VI(a). Nephroblastoma and other nonepithelial renal tumors VII. Hepatic tumors VII(a). Hepatoblastoma VIII. Malignant bone tumors VIII(a). Osteosarcomas VIII(c). Ewing tumor and related sarcomas of bone IX. Soft tissue and other extraosseous sarcomas IX(a). Rhabdomyosarcomas X. Germ cell & trophoblastic tumors & neoplasms of gonads X(a). Intracranial & intraspinal germ cell tumors X(c). Malignant gonadal germ cell tumors XI. Other malignant epithelial neoplasms and melanomas XI(b). Thyroid carcinomas XI(d). Malignant melanomas XII. Other & unspecified malignant neoplasms Rates are per million. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. 2 See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3 Abbreviations: S.E. - Standard Error; CNS - Central Nervous System.

172 CANADA III-143 Pediatric Age-adjusted Rates All Races Total Cancer Cases and Average Annual Age-adjusted Incidence Rates 1 for Pediatric Cancers NAACCR Canadian Combined 2, , All Races, Males Ages 0-14 Ages U.S Cdn 2000 U.S Cdn Cancer Types Count Rate S.E. 3 Rate S.E. Count Rate S.E. Rate S.E. All Sites , I. Leukemias I(a). Lymphoid leukemias I(b). Acute myeloid leukemias II. Lymphomas & reticuloendothelial neoplasms II(a). Hodgkin lymphomas II(b, c, e). Non-Hodgkin lymphomas III. CNS 3 & misc. intracranial & intraspinal neoplasms III(a). Ependymomas and choroids plexus tumor III(b). Astrocytomas III(c). Intracranial and intraspinal embryonal tumors III(d). Other gliomas IV. Neuroblastoma and other peripheral nervous cell tumors IV(a). Neuroblastoma & ganglioneuroblastoma V. Retinoblastoma VI. Renal Tumors VI(a). Nephroblastoma and other nonepithelial renal tumors VII. Hepatic tumors VII(a). Hepatoblastoma VIII. Malignant bone tumors VIII(a). Osteosarcomas VIII(c). Ewing tumor and related sarcomas of bone IX. Soft tissue and other extraosseous sarcomas IX(a). Rhabdomyosarcomas X. Germ cell & trophoblastic tumors & neoplasms of gonads X(a). Intracranial & intraspinal germ cell tumors X(c). Malignant gonadal germ cell tumors XI. Other malignant epithelial neoplasms and melanomas XI(b). Thyroid carcinomas XI(d). Malignant melanomas XII. Other & unspecified malignant neoplasms Rates are per million population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age and to the 1996 Canadian population standard. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. 2 See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3 Abbreviations: S.E. - Standard Error; CNS - Central Nervous System.

173 Total Cancer Cases and Average Annual Age-adjusted Incidence Rates 1 for Pediatric Cancers NAACCR Canadian Combined 2, , All Races, Females CANADA Pediatric Age-adjusted Rates All Races III-144 Ages 0-14 Ages U.S Cdn 2000 U.S Cdn Cancer Types Count Rate S.E. 3 Rate S.E. Count Rate S.E. Rate S.E. All Sites , I. Leukemias I(a). Lymphoid leukemias I(b). Acute myeloid leukemias II. Lymphomas & reticuloendothelial neoplasms II(a). Hodgkin lymphomas II(b, c, e). Non-Hodgkin lymphomas III. CNS 3 & misc. intracranial & intraspinal neoplasms III(a). Ependymomas and choroids plexus tumor III(b). Astrocytomas III(c). Intracranial and intraspinal embryonal tumors III(d). Other gliomas IV. Neuroblastoma and other peripheral nervous cell tumors IV(a). Neuroblastoma & ganglioneuroblastoma V. Retinoblastoma VI. Renal Tumors VI(a). Nephroblastoma and other nonepithelial renal tumors VII. Hepatic tumors VII(a). Hepatoblastoma VIII. Malignant bone tumors VIII(a). Osteosarcomas VIII(c). Ewing tumor and related sarcomas of bone IX. Soft tissue and other extraosseous sarcomas IX(a). Rhabdomyosarcomas X. Germ cell & trophoblastic tumors & neoplasms of gonads X(a). Intracranial & intraspinal germ cell tumors X(c). Malignant gonadal germ cell tumors XI. Other malignant epithelial neoplasms and melanomas XI(b). Thyroid carcinomas XI(d). Malignant melanomas XII. Other & unspecified malignant neoplasms Rates are per million population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age and to the 1996 Canadian population standard. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. 2 See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3 Abbreviations: S.E. - Standard Error; CNS - Central Nervous System.

174

175 NAACCR North American Combined Pediatric Cancer Incidence Seattle Puget Sound Greater Bay Area Metro Detroit Los Angeles Washington D.C. Metro Atlanta Participating Registries NORTH AMERICA Pediatric Cancer III-146

176 NORTH AMERICA III-147 Pediatric Age-specific Rates All Races Total Cancer Cases and Average Annual Age-specific Incidence Rates 1 for Pediatric Cancers NAACCR North American Combined 2, , All Races, Males Ages 0-4 Ages 5-9 Ages Ages Cancer Types Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. All Sites 12, , , , I. Leukemias 4, , , , I(a). Lymphoid leukemias 3, , , , I(b). Acute myeloid leukemias II. Lymphomas & reticuloendothelial neoplasms , , , II(a). Hodgkin lymphomas , II(b, c, e). Non-Hodgkin lymphomas , III. CNS 3 & misc. intracranial & intraspinal neoplasms 2, , , , III(a). Ependymomas and choroids plexus tumor III(b). Astrocytomas III(c). Intracranial and intraspinal embryonal tumors III(d). Other gliomas IV. Neuroblastoma and other peripheral nervous cell tumors 1, IV(a). Neuroblastoma & ganglioneuroblastoma 1, V. Retinoblastoma VI. Renal Tumors VI(a). Nephroblastoma and other nonepithelial renal tumors VII. Hepatic tumors VII(a). Hepatoblastoma VIII. Malignant bone tumors VIII(a). Osteosarcomas VIII(c). Ewing tumor and related sarcomas of bone IX. Soft tissue and other extraosseous sarcomas IX(a). Rhabdomyosarcomas X. Germ cell & trophoblastic tumors & neoplasms of gonads , X(a). Intracranial & intraspinal germ cell tumors X(c). Malignant gonadal germ cell tumors , XI. Other malignant epithelial neoplasms and melanomas , XI(b). Thyroid carcinomas XI(d). Malignant melanomas XII. Other & unspecified malignant neoplasms Rates are per million. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. 2 See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3 Abbreviations: S.E. - Standard Error; CNS - Central Nervous System.

177 Total Cancer Cases and Average Annual Age-specific Incidence Rates 1 for Pediatric Cancers NAACCR North American Combined 2, , All Races, Females NORTH AMERICA Pediatric Age-specific Rates All Races III-148 Ages 0-4 Ages 5-9 Ages Ages Cancer Types Count Rate S.E. 3 Count Rate S.E. Count Rate S.E. Count Rate S.E. All Sites 10, , , , I. Leukemias 3, , , , I(a). Lymphoid leukemias 3, , I(b). Acute myeloid leukemias II. Lymphomas & reticuloendothelial neoplasms , , II(a). Hodgkin lymphomas , II(b, c, e). Non-Hodgkin lymphomas III. CNS 3 & misc. intracranial & intraspinal neoplasms 2, , , , III(a). Ependymomas and choroids plexus tumor III(b). Astrocytomas III(c). Intracranial and intraspinal embryonal tumors III(d). Other gliomas IV. Neuroblastoma and other peripheral nervous cell tumors 1, IV(a). Neuroblastoma & ganglioneuroblastoma 1, V. Retinoblastoma VI. Renal Tumors 1, VI(a). Nephroblastoma and other nonepithelial renal tumors 1, VII. Hepatic tumors VII(a). Hepatoblastoma VIII. Malignant bone tumors VIII(a). Osteosarcomas VIII(c). Ewing tumor and related sarcomas of bone IX. Soft tissue and other extraosseous sarcomas IX(a). Rhabdomyosarcomas X. Germ cell & trophoblastic tumors & neoplasms of gonads X(a). Intracranial & intraspinal germ cell tumors X(c). Malignant gonadal germ cell tumors XI. Other malignant epithelial neoplasms and melanomas , XI(b). Thyroid carcinomas , XI(d). Malignant melanomas XII. Other & unspecified malignant neoplasms Rates are per million. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. 2 See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3 Abbreviations: S.E. - Standard Error; CNS - Central Nervous System.

178 NORTH AMERICA III-149 Pediatric Age-adjusted Rates All Races Total Cancer Cases and Average Annual Age-adjusted Incidence Rates 1 for Pediatric Cancers NAACCR North American Combined 2, , All Races, Males Ages 0-14 Ages U.S Cdn 2000 U.S Cdn Cancer Types Count Rate S.E. 3 Rate S.E. Count Rate S.E. Rate S.E. All Sites 26, , I. Leukemias 8, , I(a). Lymphoid leukemias 6, , I(b). Acute myeloid leukemias 1, , II. Lymphomas & reticuloendothelial neoplasms 3, , II(a). Hodgkin lymphomas 1, , II(b, c, e). Non-Hodgkin lymphomas 1, , III. CNS 3 & misc. intracranial & intraspinal neoplasms 5, , III(a). Ependymomas and choroids plexus tumor III(b). Astrocytomas 2, , III(c). Intracranial and intraspinal embryonal tumors 1, , III(d). Other gliomas , IV. Neuroblastoma and other peripheral nervous cell tumors 1, , IV(a). Neuroblastoma & ganglioneuroblastoma 1, , V. Retinoblastoma VI. Renal Tumors 1, , VI(a). Nephroblastoma and other nonepithelial renal tumors 1, , VII. Hepatic tumors VII(a). Hepatoblastoma VIII. Malignant bone tumors 1, , VIII(a). Osteosarcomas , VIII(c). Ewing tumor and related sarcomas of bone IX. Soft tissue and other extraosseous sarcomas 1, , IX(a). Rhabdomyosarcomas , X. Germ cell & trophoblastic tumors & neoplasms of gonads , X(a). Intracranial & intraspinal germ cell tumors X(c). Malignant gonadal germ cell tumors , XI. Other malignant epithelial neoplasms and melanomas , XI(b). Thyroid carcinomas XI(d). Malignant melanomas XII. Other & unspecified malignant neoplasms Rates are per million population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age and to the 1996 Canadian population standard. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. 2 See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3 Abbreviations: S.E. - Standard Error; CNS - Central Nervous System.

179 Total Cancer Cases and Average Annual Age-adjusted Incidence Rates 1 for Pediatric Cancers NAACCR North American Combined 2, , All Races, Females NORTH AMERICA Pediatric Age-adjusted Rates All Races III-150 Ages 0-14 Ages U.S Cdn 2000 U.S Cdn Cancer Types Count Rate S.E. 3 Rate S.E. Count Rate S.E. Rate S.E. All Sites 23, , I. Leukemias 7, , I(a). Lymphoid leukemias 5, , I(b). Acute myeloid leukemias 1, , II. Lymphomas & reticuloendothelial neoplasms 1, , II(a). Hodgkin lymphomas , II(b, c, e). Non-Hodgkin lymphomas , III. CNS 3 & misc. intracranial & intraspinal neoplasms 4, , III(a). Ependymomas and choroids plexus tumor III(b). Astrocytomas 2, , III(c). Intracranial and intraspinal embryonal tumors , III(d). Other gliomas , IV. Neuroblastoma and other peripheral nervous cell tumors 1, , IV(a). Neuroblastoma & ganglioneuroblastoma 1, , V. Retinoblastoma VI. Renal Tumors 1, , VI(a). Nephroblastoma and other nonepithelial renal tumors 1, , VII. Hepatic tumors VII(a). Hepatoblastoma VIII. Malignant bone tumors 1, , VIII(a). Osteosarcomas VIII(c). Ewing tumor and related sarcomas of bone IX. Soft tissue and other extraosseous sarcomas 1, , IX(a). Rhabdomyosarcomas X. Germ cell & trophoblastic tumors & neoplasms of gonads , X(a). Intracranial & intraspinal germ cell tumors X(c). Malignant gonadal germ cell tumors XI. Other malignant epithelial neoplasms and melanomas 1, , XI(b). Thyroid carcinomas , XI(d). Malignant melanomas , XII. Other & unspecified malignant neoplasms Rates are per million population and are age-adjusted by five-year age groups to the 2000 U.S. standard population based on single years of age and to the 1996 Canadian population standard. Counts and rates are suppressed when fewer than 6 cases were reported for the specific cancer. The suppressed cases, however, are included in the counts and rates for All Sites combined. 2 See Technical Notes, Section I, for NAACCR area inclusion criteria for the combined cancer statistics. 3 Abbreviations: S.E. - Standard Error; CNS - Central Nervous System.

180

181 Section IV NAACCR Combined Stage at Diagnosis by Age for Select Cancer Sites in the United States, Canada and North America Seattle Puget Sound Greater Bay Area Metro Detroit Los Angeles Washington D.C. Metro Atlanta Participating Registries