Let s start first reviewing the clinical and pathological features of IBC.
|
|
- Cornelia Martin
- 5 years ago
- Views:
Transcription
1 Welcome to this educational event sponsored by [The University of Texas] MD Anderson Cancer Center, entitled Inflammatory Breast Cancer: Biological Features. I am Massimo Cristofanilli. I m a Professor of Medicine and an expert in inflammatory breast cancer as a physician-scientist involved with research and clinical management of this disease. Today s objectives of this presentation are: understanding the clinical and pathological features of inflammatory breast cancer; understanding the role of targeted therapies in the standard management of the disease; and also understanding the new molecular targets with potential therapeutic application. Let s start first reviewing the clinical and pathological features of IBC. We know this is an advanced disease so it has to be treated by a multidisciplinary team of physicians. And this requires induction on neoadjuvant chemotherapy typically involving anthracyclines and taxanes, followed by mastectomy, and chest wall radiation. This is the standard of care for inflammatory breast cancer. Patients completing induction chemotherapy are then evaluated at the time of mastectomy for pathological response. The complete pathological response is the most important prognostic factor. Past Studies: I reviewed the importance of surgery in the multimodality management of IBC. This experience from Dr. Panades and the Canadian group published in JCO, 2005, suggests that omitting mastectomy is responsible for an increased locoregional relapse. And the sequence of mastectomy after chemotherapy and radiation therapy is the best possible sequence. At MD Anderson we reviewed the retrospective experience of these patients that completed neoadjuvant therapy, particularly to evaluate the risk factors associated with recurrence. And we saw that the pathological CR in the axillary node is probably the most important factor. This graph reproduced the probability of progression-free survival; survival for patients without evidence of axillary lymph node disease or with axillary lymph node disease. So looking at the retrospective evaluations of patients treated with multimodality therapy, particularly with anthracycline-based regimens, where you can see that in the last 30 years most of the experience suggests that the major change in prognosis is related to the inclusion of chemotherapy in the neoadjuvant setting and adjuvant setting of these patients from only locoregional treatment. Back in 1970s, the treatment of this disease consisted only of surgery and/or radiation. But over the last decades the management of this disease has really not improved significantly, continues to offer a significant low survival probability at 5 years compared to other forms of breast cancer. When you look at the pathological features at the time of diagnosis and time of surgery, we can see in these two figures. One on the left suggested a patient that at the time of surgery has extensive edema in the skin still, even though there is no evidence of mass
2 in the center of the breast. The disease will remain eventually. And patients do not respond in the skin where originally the patients had the clinical evidence of disease. At the time of diagnosis, the typical presentation [was] represented by tumor emboli, the classes of cancer cells that occupy and block the lymphatics. So for the first time the pathology at diagnosis being us the importance of the lymphatics. Lymphangiogenesis is, in fact, an important factor in inflammatory breast cancer. Several investigators have demonstrated that the particular way of this disease to spread, is from invading the lymphatics, as we show in this particular slide. And it has been hypothesized that this is actually a possible passive phenomenon. But most recent research has demonstrated that this is an active phenomenon and the first step in the process of metastasis in inflammatory breast cancer. This lymphatic spread is actually extremely important because even in patients that achieve optimal response, but not a pathological response, their recurrence happens very early on in the first two or three years compared to non-inflammatory breast cancer. These translate in a difference of recurrence-free survival that is quite significant. It is believed that this is related to the persistence of micrometastatic disease distantly and also in the lymphatics. When we go to analyze where does this recurrence occur, we found out that actually the incidence of soft tissue recurrence is extremely high; suggesting once again that the lymphatic spread within the skin is an important contributor to the recurrence. Most of these patients had, in fact, chest wall recurrence or lymph node recurrence locally. The results of distant soft tissue recurrence that is quite significant compared to noninflammatory breast cancer. Once again highlighting the specific and important role of lymphangiogenesis and the difference in the biology underlying this particular type of spreading. So we can now move on reviewing the targeted therapy that are currently utilized in the standard management of inflammatory breast cancer. We previously mentioned that the combination of neoadjuvant chemotherapy, surgery, radiation, constitute the standard experience for a patient with inflammatory breast cancer. This comes from retrospective studies and prospective clinical trials that are being ran at the MD Anderson since Actually the first study that was in 1974 to 76 and did not include surgery but radiation therapy was the only local modality. Subsequently all the protocols include mastectomy. They were testing different strategy in terms of chemotherapy including adjuvant chemotherapy, non-cross-resistant regimens, and additional evaluation of patients in non-cross-resistant regimens based on the quality of pathological response. So these protocols actually were compared and did not show significant difference in terms of complete clinical response. Obviously the pathological response could not be assessed in the first group of patients that had only radiation therapy. So maintaining
3 overall around 12%, obviously quite low compared to what we see in other forms of breast cancer. So we started to look at the various biomarkers that could explain or identify patients with a high recurrence rate and worse prognosis. And the first one we looked at was HER-2. And as you recall, HER-2 has been associated with poor prognosis in early breast cancer. But in this particular disease, very aggressive, you see that HER-2 status at presentation, in patients who did not receive HER-2 targeted therapy, but only chemotherapy, is not associated with recurrence-free survival probability. And overall survival is better in this group once they start HER-2 targeted therapy for their recurrent disease. So this brought to the introduction, of course, of Herceptin in the neoadjuvant management of these patients or the induction phase, and the --- the NOAH study is very much one of the most important protocols in this sense because it included HER2- positive patients locally advanced and inflammatory breast cancer that were compared receiving the same chemotherapy or chemotherapy with Herceptin. And the group that received chemoth --- Herceptin continued also with Herceptin. There was also a control arm that were HER2-negative locally advanced patients. You can see from this slide that there were a number of patients with HER2-positive disease. Most of the HER2-positive disease were also ER- or PR-negative. So makes it obviously quite an attractive patient population to study with neoadjuvant treatment. And the results was as expected, as seen in other non-inflammatory disease, particularly the --- in HER2-positive, the addition of chemotherapy brought up the pathological CR within the breast to 55% and total eradication of the disease, invasive disease within the breast and the lymph node to 48%. So quite a significant improvement when compared to the overall 12% that we achieved only with chemotherapy. When you look at a patient that achieved pathological CR, they do much better obviously when they receive Herceptin ; their survival is better, and overall, the survival is better irrespective of the pathological CR. Again we are comparing a group of patients treated with Herceptin and treated without Herceptin with just chemotherapy. So this makes Herceptin the standard therapy for HER2-positive inflammatory breast cancer, particularly in the neoadjuvant setting, followed by the adjuvant disease treatment. So at MD Anderson, we also reviewed the retrospective experience of patients that received neoadjuvant therapy with trastuzumab-based regimens. These were a group of 16 newly diagnosed, treatment-naïve patients who received preoperative trastuzumab and chemotherapy. The chemotherapy were two different regimens FEC-Paclitaxel, and TCH according to the investigator choice, that were administered for 20 weeks. Ten patients had a pathological complete response, approximately 62%.
4 It is interesting to know that even Stage IV disease was included in this analysis, and they proceeded with surgery and were able to obtain pathological complete response. When we looked at the follow-up at 24 months, we noticed that these patients had --- had evidence of recurrence and for the first time, we started to notice that this disease is associated with a significant high incidence of brain metastasis even in patients who have high pathological complete responses. So we started to look at the role of chemokines and growth factor receptors, excluding HER2, particular for the homing of --- of metastasis in particular sites. As I mentioned, the chest wall disease, but also the bone, and the brain. And we looked at the CXCL4, EGFR, also HER2, and CCR7. And what we noticed is that what the chemokine independently did not have, in terms of expression, [was] any correlation with prognosis. EGFR had a significant association. Even with this small study, only 43 patients, EFGR-positive definitely performed worse. And these were all patients that completed neoadjuvant chemotherapy had residual disease after surgery. So we started to investigate how a treatment targeting EGFR could eventually contribute to reduce the metastatic process. And we looked, in specific, at the ERK signal and the EMT phenomenon associated with the metastatic process, in particular for IBC. So this was SUM 149 cell lines that were treated with different doses of erlotinib. And we see with different doses of erlotinib there is more apoptosis for the cells. And there is a decrease in the expression of vimentin, suggesting that the reverse of the EMT phenomenon; suggesting somewhat that this drugs, or this class of drug, could be used to reverse or to prevent the metastatic process and maybe should be considered for the adjuvant treatment of inflammatory breast cancer. But certainly one drug that has made a significant contribution to the management of IBC is the use of lapatinib. As we know lapatinib is a receptor tyrosine kinase inhibitor that prevents the phosphorylation and activation of EGFR and HER2, so it is an optimal drug for a disease in which EGFR has also a significant role. So the dual blockage of the signal is very appealing for this disease. So the first study was actually evaluating as a single agent, the role of lapatinib in patients that were HER2-positive or EGFR-positive/HER2-negative. And these patients received a biopsy before starting the treatment, were treated with lapatinib as a single agent. There was extensive evaluation of chest wall disease as well as evaluation of the measurable disease by RECIST criteria. And this study confirmed actually that in spite of the dual inhibition, the lapatinib treatment only show eff --- efficacy in patients that were HER2-positive and not EGFRpositive/HER2-negative. So this is a demonstration of patient, a typical patient with chest wall disease during treatment had almost a complete disappearance of her chest wall disease. And this was proved also by the PET-CT associated with some
5 lymphadenopathy. This is a typical inflammatory breast patient with local disease and chest wall disease. And in fact, the evaluation demonstrated this disease is effective also in patients who have been exposed to long treatment with HER2 targeted therapy with Herceptin. In fact, the median number of cycles of different regimens was six in these studies and you see the efficacy is still being present. This is cumulative progression-free survival over weeks. So it clearly establish that lapatinib is an effective agent in the management of HER2-positive inflammatory breast cancer. So the next step was trying to evaluate how we could improve in the efficacy of lapatinib. We know that from preclinical models, that inflammatory breast cancer has a specific process of vasculogenic mimicry that is associated with the recapitulation of the lymphatic vessels in the endothelial lining of the vessels, and this favors the tumor emboli spreading. This has been shown with various models of inflammatory breast cancer, SUM149, IBC- 1, and this suggests that lymphangiogenesis and angiogenesis are important factors in the spreading of inflammatory breast cancer cells. So targeting angiogenesis and lymphangiogenesis could be an optimal strategy to treat the disease, possibly together with lapatinib. That was the rationale behind the study conducted at MD Anderson, a multicenter --- a multicenter study of lapatinib/pazopanib versus lapatinib, single agent, in patients with HER2-positive inflammatory breast cancer. The primary objective of this study was, of course, to evaluate objective response of this combination versus the monotherapy in these patients who are refractory to HER2 targeted therapy or relapsed. And they are not been exposed to HER2 targeted therapy yet. And we want to evaluate the overall surviv --- progression-free survival, response -- - response duration, and safety. Safety was actually an important concern for this study. The study started with an ambitious goal of demonstrating in a randomized fashion the superiority of the combination versus the single agent. But the dose chosen of 1500 lapatinib and pazopanib 800 were not tolerable. So that the new design actually included a reduced dose of lapatinib and pazopanib, and the third arm of pazopanib as a control. So we have two cohorts of patients treated, with a number of patients that you see outlined in this slide. The inclusion criteria were very clear. These should have metastatic HER2-positive inflammatory breast cancer to define by either immunohistochemistry of FISH or combination of both, normal organ function,
6 and they should not have been exposed to lapatinib but could have been exposed to Herceptin and should not have been exposed to any other anti-vegf angiogenetic therapy. The assessment of response was actually very carefully done, in particular, with regard to the skin disease. In fact, the first cohort was assessed using evaluation of the Skin Assessment Tool that has been developed for T-cell lymphoma. And this was evaluating the skin, the breast, and recorded very carefully for the known measurable disease. In the second cohort, all patients were required to have skin disease, and it was --- an evaluation tool was developed to improve on the previous one. It was called the Inflammatory Breast Cancer Skin Assessment Tool. This will allow comparison of assessment from different investigators; in particular in cases that was a discordance. So once again, evaluation of response for RECIST criteria for measurable disease and overall survival from the date of randomization. This slide summarizes the characteristics of the patients in the two cohorts. You see overall, there is a consistence in terms of median age and population in terms of re --- race and stage. The majority of patients were in fact Stage IV and half of them had received previous Herceptin. All of them had received previous chemotherapy. When we look at the treatment adverse events, lapatinib has the acceptable GI toxicity that s been described previously and minimal increase in liver function tests. But notice the combination with the higher dose actually resulted in increase in the GI toxicity as well as increase of liver toxicity that required the modification of this dose. And this was the basis for the Cohort 2. Actually the second cohort did not have significant problem, was much better tolerated. When we look at the response rate between the two, remember this is a combination of best response, measurable response, and non-measurable response. There is a trend in having the group of patients that has a combination to a better response, compared to the one that have single arm management. And this is for both cohorts. But this actually did not translate in an improved progression-free survival. So there was no difference in progression-free survival between the three arms, and there was no difference between the two arms in the Cohort 1. To notice, the median progressionfree survival is 16 weeks, is compatible and is slightly superior actually, in this particular study, compared to others that are investigating lapatinib as a single agent. Suggesting once again, that lapatinib is a --- is an extremely important agent for the management of HER2-positive inflammatory breast cancer. So obviously after having -revised --- reviewed the details of the retrospective study done in metastatic disease, lapatinib is also being tested in primary inflammatory breast cancer, with some limitations, I would say, particularly because the first studies we were investigating once
7 again the role of lapatinib in two populations of ErbB2-positive, ErbB1-positive/HER2- negative, and did not include, particularly the first study, any treatment with anthracycline. This combination only includes lapatinib/paclitaxel, which was associated once again with some GI toxicity. And these patients will receive this combination before undergoing clinical assessment, subsequent to surgery, and then received the additional chemotherapy with anthracycline and Herceptin completion as an adjuvant treatment. This study showed that it is possible to achieve a pathological response in these patients treated only with taxane and lapatinib, and this translates in a pathological response of 17%; obviously, a shorter period of time treatment, lack of anthracyclines. And this paper was published in the JCO in 2010 suggests the feasibility of this combination for patients that had HER2-positive Stage III inflammatory breast cancer. So this prompted [us] to design of another study which we wanted to introduce anthracyclines after taxane together with lapatinib in order to evaluate the full benefit of HER2 blockage, together with the longer chemotherapy and more standard chemotherapy in patients with inflammatory breast cancer. This study was designed as a two-step design, Simon design, and unfortunately, after the first 14 patients, there was no evidence of pathological response as we defined, also with evid --- with minimal residual disease in a couple of patients, not enough to actually move to the second step. So this was abandoned, suggesting that lapatinib together with this longer chemotherapy combination does not appear to provide any additional benefit in direct comparison to combinations that use Herceptin. But the combination of anti-androgenic therapy and HER2 therapy has been tested in the neoadjuvant setting from the French group in the BEVERLY-2 study that has been presented as a first analysis, where bevacizumab and trastuzumab have been combined with chemotherapy. This is a very complex study in which epirubicin and cyclophosphamide have been given for four cycles, followed by docetaxel for four cycles. Neoadjuvant bevacizumab is given concomitantly with chemotherapy but interrupted four to six weeks in order to decrease the possibility of a complication from surgery. Neoadjuvant trastuzumab is used with the docetaxel in order to reduce the possibility of heart failure and problems. And then in the adjuvant setting after surgery, the patient would receive adjuvant trastuzumab and would restart adjuvant bevacizumab for 30 weeks. So quite heavy treatment. The first part has been presented and published, and consists in pathologic and complete response defined according to the Sataloff Classification, looking at the amount of residual disease, or residual disease burden. You see that it is quite high incidence of pathologic complete response in a --- in a total of 52 patients, suggesting that maybe [the] addition of bevacizumab on top of Herceptin with chemotherapy may contribute to increased pathological response. But this is only an assumption because there was no control arm.
8 So what about new molecular therapy for IBC? As we mentioned, the patients that do not achieve a pathological CR have a worse prognosis, have a chance of recurrence very early on, and there are limited treatments for these patients, except for the HER2- positive group. So the majority of triple negative actually do not have molecular therapies for that. So there were several studies in the last three or four years that have looked at the possibility to identify specific biomarkers that would suggest that we direct new molecular therapy. The study by Sil --- Silvera actually showed that the translation into transcriptional machinery is activated in IBC, where elf4g1 is present and associated to SUM149 IBC cell line and SUM 149 tumors, and then in an --- in vivo model, you can see that that is shutting down or using shrna in order to reduce the expression of elf4g1 is associated with reduction for marking information of tumors, slowing down the tumor growth. The tumor volume is much less and also the synthetic activity is significantly --- statistically significantly reduced. And this is the difference between the expression in normal epithelia and in IBC. So with regarding to the molecular subtypes that we use for classification of regular breast cancer, this has been also evaluated for inflammatory breast cancer. In the majority of inflammatory breast cancer class actually basal-like in the HER2-positive group, much less with luminal A or luminal B group, suggesting that these patients derive less benefit from endocrine therapy and are more aggressive overall. When we look at the different cell lines and models available for IBC, you can actually see that there is a heterogenous distribution. In fact, most of the commonly used SUM149 and Mary-X are triple negative or basal-like. SUM 149 is HER2-positive as well as 1IBC-3. And, the most recently established IBC01 is actually basal-like as well. So suggesting that somewhat the IBC phenotype is independent, at least regarding to the preclinical model from the subtype of the breast cancer. So Mary-X is certainly the model that has allowed [us] to evaluate most of the initial observations for the biology of the disease, particular because of recapitulated tumor emboli of the disease. This is a typical patient with significant breast changes, edema, and ulceration related to the establishment of tumor emboli. This is a mouse with this established inflammatory breast cancer within the skin. So this has allowed us to test various hypotheses. And we have evaluated the possibility that based on the increased expression of HDACs or histone deacetylases that histone deacetylase inhibitors would eventually differentiate the IBC cell line and make this disease less aggressive. So romidepsin after SAHA [suberoylanilide hydroxamic acid] has been tested in SUM149, SUM190, and compared to other cell lines to see if there is inhibition that is also present with the same cell line treated with Taxol. And we have done also studies of the combination;
9 suggesting that it is possible to combine three preclinical models to get a synergistic effect for these two agents. And when we look at dosage, we saw that you can achieve up to 67%, in a dose-dependent fashion, inhibition of tumor volume reduction for the --- using romidepsin alone, and you can achieve 85% of using a higher dose of paclitaxel, 50 mg/kg. So this translates in the design of a clinical trial where romidepsin in a Phase 1/Phase 2 [study] is combined with Abraxane in these patients [with] metastatic HER2-negative inflammatory breast cancer. The first phase has as the primary objective to assess the safety of this combination and to determine the maximum tolerated dose before moving to the Phase 2 that, in fact, will address the overall response rate, clinical benefit, and additional measures of efficacy. This is the scheme of the study. These are patients with inflammatory metastatic disease being treated with two or three lines of previous therapies were --- will be enrolled first in the Phase 1 with an escalating dose of romidepsin, IV, over one hour, and Abraxane would be a standard dose. The patients in Phase 2 after the maximum tolerated dose would be established, would be evaluated probably in the first or second line, in order to asses really the full benefit of this --- this disease treatment. At the same time we would have correlative studies looking at re-expression of markers of --- of differentiation, of particular, ER and other factors. And also would measure CDCs as a way to address rate of response. So that protocol is going to be activated soon and will be available to patients. We also identified anaplastic lymphoma receptor tyrosine kinase [ALK] as a potential new target in inflammatory breast cancer. Now the ALK is certainly not known to be a molecular target for breast cancer. It has been found, in fact, to [be] rearranged, mutated, amplified in los --- anaplastic large cell lymphoma, neuroblastoma, and non-small cell lung cancer. Only in a very small fraction of patients with triple negative breast cancer, mostly amplified or overexpressed. So where in preclinical work in collaboration with Dr. Petricoin at George Mason University, we evaluated the protein expression level of this phospho-alk. And we compared this with non-small cell lung cancer where this drug --- drugs for ALK targeting had been approved. We see the IBC actually clusters with non-small cell lung cancer different from the non-ibc breast cancer. So we went back to our models and looked at the expression as well as the amplification level. We saw that ALK, for example, in the Mary-X is overexpressed and is a different copy number in Mary-X as well as IBC-01 and 02 new models being established for IBC.
10 This prompted [us] to go back to the tissue that had been collected at MD Anderson present in the database to look at the gene expression. This is very heterogenous and independent overall, appeared to be from the subtypes. So we went back and used the IBC-01 tumor xenografts in order to establish --- some proof of concept that crizotinib can actually affect cell viability and survival and also can induce apoptosis in this particular tumor model. So in conclusion, we showed that the histopathological characteristics of IBC is certainly characterized by extensive dermolymphatic invasion and the formation of tumor emboli, very critical for the lymphatic spreading in the metastatic process to be initiated. There are abnormal molecular pathways associated with angiogenesis, hypoxia, lymphangiogenesis, chemokines for the homing of cancer cells, growth factor receptors, and transcription factors. All of these represent an area for further investigation. For the standard treatment of HER2-positive patients, agents like lapatinib definitely show activity as a single agent, trastuzumab combination activity in primary recurrent IBC, representing now the standard neoadjuvant management of IBC patients. And novel targets are --- are being identified and it is possible that this will be translated very soon in promising clinical trials that can improve the overall prognosis and the outcome of these patients. I want to acknowledge the support from the grant from the State of Texas, Rare Aggressive Breast Cancer Research, and the American Airlines support of Susan G. Komen Promise Grant to Fredika Robertson, who contributed most of this data and the new findings. And I welcome every one of you that wants to have any additional information about this terrible disease to contact us through our website. Thank you.
Management of Inflammatory Breast Cancer: Collaboration is the path forward
Management of Inflammatory Breast Cancer: Collaboration is the path forward Massimo Cristofanilli, M.D., F.A.C.P. Professor of Medicine Associate Director of Translational Research and Precision Medicine
More informationDennis J Slamon, MD, PhD
I N T E R V I E W Dennis J Slamon, MD, PhD Dr Slamon is Professor of Medicine, Chief of the Division of Hematology/Oncology and Director of Clinical and Translational Research at UCLA s David Geffen School
More informationThe absolute benefit from chemotherapy for both older and younger patients appeared most significant in ER-negative populations.
Hello, my name is Diane Hecht, and I am a Clinical Pharmacy Specialist at the University of Texas MD Anderson Cancer Center. It s my pleasure to talk to you today about the role of chemotherapy in this
More informationSo, we already talked about that recognition is the key to optimal treatment and outcome.
Hi, I m Dr. Anthony Lucci from the University of Texas MD Anderson Cancer Center in Houston. And today, I d like to talk to you about the role of surgery in inflammatory breast cancer patients. So, there
More informationIt is a malignancy originating from breast tissue
59 Breast cancer 1 It is a malignancy originating from breast tissue including both early stages which are potentially curable, and metastatic breast cancer (MBC) which is usually incurable. Most breast
More informationclear evidence of the signs and symptoms of infection, simply a breast cancer that looks like infection.
Hello, and welcome to The University of Texas MD Anderson Cancer Center lecture series on Inflammatory Breast Cancer. In this section we ll discuss the clinical diagnosis of IBC. My name is Wendy Woodward
More informationReview of adjuvant and neo-adjuvant abstracts from SABCS 2011 January 7 th 2012
Review of adjuvant and neo-adjuvant abstracts from SABCS 2011 January 7 th 2012 Ruth M. O Regan, MD Professor and Vice-Chair for Educational Affairs, Department of Hematology and Medical Oncology, Emory
More information10/15/2012. Inflammatory Breast Cancer vs. LABC: Different Biology yet Subtypes Exist
Triple-Negative Breast Cancer: Optimizing Treatment for Locally Advanced Breast Cancer Beth Overmoyer MD Director, Inflammatory Breast Cancer Program Dana Farber Cancer Institute Overview Inflammatory
More informationBreast Cancer. Excess Estrogen Exposure. Alcohol use + Pytoestrogens? Abortion. Infertility treatment?
Breast Cancer Breast Cancer Excess Estrogen Exposure Nulliparity or late pregnancy + Early menarche + Late menopause + Cystic ovarian disease + External estrogens exposure + Breast Cancer Excess Estrogen
More informationThe Role of Pathologic Complete Response (pcr) as a Surrogate Marker for Outcomes in Breast Cancer: Where Are We Now?
1 The Role of Pathologic Complete Response (pcr) as a Surrogate Marker for Outcomes in Breast Cancer: Where Are We Now? Terry Mamounas, M.D., M.P.H., F.A.C.S. Medical Director, Comprehensive Breast Program
More informationSystemic Therapy Considerations in Inflammatory Breast Cancer
Systemic Therapy Considerations in Inflammatory Breast Cancer Shani Paluch-Shimon, MBBS, MSc Director, Breast Oncology Unit Shaare Zedek Medical Centre, Jerusalem Israel Disclosures Roche: Speakers bureau,
More informationIndex. Note: Page numbers of article titles are in boldface type.
Note: Page numbers of article titles are in boldface type. A Adjuvant therapy, for early-stage triple-negative breast cancer, 740 742 in older early-stage breast cancer patients, 790 795 anti-her2-directed
More informationTraditional Approaches to Treating NSCLC, Part 2: Neoadjuvant Combined Modality, Locally Advanced, and Metastatic NSCLC
Transcript Details This is a transcript of a continuing medical education (CME) activity accessible on the ReachMD network. Additional media formats for the activity and full activity details (including
More informationOpen Clinical Trials: What s Out There Now Paula D. Ryan, MD, PhD
Open Clinical Trials: What s Out There Now Paula D. Ryan, MD, PhD Hanahan and Weinberg, 2000 Acquired Capabilities of Cancer Clinical Trials When should I consider a clinical trial? How do I find the right
More informationTreatment Options for Breast Cancer in Low- and Middle-Income Countries: Adjuvant and Metastatic Systemic Therapy
Women s Empowerment Cancer Advocacy Network (WE CAN) Conference Bucharest, Romania October 2015 Treatment Options for Breast Cancer in Low- and Middle-Income Countries: Adjuvant and Metastatic Systemic
More informationBreast Cancer Earlier Disease. Stefan Aebi Luzerner Kantonsspital
Breast Cancer Earlier Disease Stefan Aebi Luzerner Kantonsspital stefan.aebi@onkologie.ch Switzerland Breast Cancer Earlier Disease Diagnosis and Prognosis Local Therapy Surgery Radiation therapy Adjuvant
More informationNavigating Treatment Pathways in Relapsed/Refractory Hodgkin Lymphoma
Welcome to Managing Hodgkin Lymphoma. I am Dr. John Sweetenham from Huntsman Cancer Institute at the University of Utah. In today s presentation, I will be discussing navigating treatment pathways in relapsed
More informationEARLY STAGE BREAST CANCER ADJUVANT CHEMOTHERAPY. Dr. Carlos Garbino
EARLY STAGE BREAST CANCER ADJUVANT CHEMOTHERAPY Dr. Carlos Garbino EARLY BREAST CANCER ADJUVANT CHEMOTHERAPY SUSTANTIVE DIFFICULTIES FOR A WORLDWIDE APPLICABILITY DUE TO IMPORTANT INEQUALITIES + IN DIFFERENT
More informationBreast Cancer: the interplay of biology, drugs, radiation. Prof. L. Livi Università degli Studi di Firenze. Brescia, October 3rd 4th, 2013
Breast Cancer: the interplay of biology, drugs, radiation Prof. L. Livi Università degli Studi di Firenze Brescia, October 3rd 4th, 2013 BACKGROUND (1) The complex interactions between tumor-specific signaling
More informationBreast Cancer Basics. Clinical Oncology for Public Health Professionals. Ben Ho Park, MD, PhD
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike License. Your use of this material constitutes acceptance of that license and the conditions of use of materials on this
More informationSee Important Reminder at the end of this policy for important regulatory and legal information.
Clinical Policy: (Herceptin) Reference Number: ERX.SPA.42 Effective Date: 07.01.16 Last Review Date: 05/17 Line of Business: Commercial [Prescription Drug Plan] Revision Log See Important Reminder at the
More informationIntro to Cancer Therapeutics
An Intro to Cancer Therapeutics Christopher R. Chitambar, MD Professor of Medicine Division of Hematology & Oncology Froedtert and Medical College of Wisconsin Clinical Cancer Center cchitamb@mcw.edu Intro
More informationHighlights: 2008 San Antonio Breast Cancer Symposium
Transcript Details This is a transcript of an educational program accessible on the ReachMD network. Details about the program and additional media formats for the program are accessible by visiting: https://reachmd.com/programs/conference-coverage/highlights-2008-san-antonio-breast-cancersymposium/4099/
More informationNeo-adjuvant and adjuvant treatment for HER-2+ breast cancer
Neo-adjuvant and adjuvant treatment for HER-2+ breast cancer Angelo Di Leo «Sandro Pitigliani» Medical Oncology Unit Hospital of Prato Istituto Toscano Tumori Prato, Italy NOAH: Phase III, Open-Label Trial
More informationCase Scenario 1. 2/15/2011 The patient received IMRT 45 Gy at 1.8 Gy per fraction for 25 fractions.
Case Scenario 1 1/3/11 A 57 year old white female presents for her annual mammogram and is found to have a suspicious area of calcification, spread out over at least 4 centimeters. She is scheduled to
More information4/13/2010. Silverman, Buchanan Breast, 2003
Tailoring Breast Cancer Treatment: Has Personalized Medicine Arrived? Judith Luce, M.D. San Francisco General Hospital Avon Comprehensive Breast Care Center Outline First, treatment of DCIS Sorting risk
More informationSYSTEMIC TREATMENT OF TRIPLE NEGATIVE BREAST CANCER
SYSTEMIC TREATMENT OF TRIPLE NEGATIVE BREAST CANCER Sunil Shrestha 1*, Ji Yuan Yang, Li Shuang and Deepika Dhakal Clinical School of Medicine, Yangtze University, Jingzhou, Hubei Province, PR. China Department
More informationClinico- Pathological Features And Out Come Of Triple Negative Breast Cancer
Clinico- Pathological Features And Out Come Of Triple Negative Breast Cancer Dr. HassanAli Al-Khirsani, MBChB, CABM, F.I.C.M.S AL-Sadder teaching hospital, oncology unit Dr. Nasser Ghaly Yousif, MBChB,G.P.
More informationTriple Negative Breast Cancer. Eric P. Winer, MD Dana-Farber Cancer Institute Harvard Medical School Boston, MA October, 2008
Triple Negative Breast Cancer Eric P. Winer, MD Dana-Farber Cancer Institute Harvard Medical School Boston, MA October, 2008 Triple Negative Breast Cancer 15% 25% Triple Negative 20% HER2+ ER+ Low Grade
More informationAntibody-Drug Conjugates in Glioblastoma Multiforme: Finding Ways Forward
Transcript Details This is a transcript of a continuing medical education (CME) activity accessible on the ReachMD network. Additional media formats for the activity and full activity details (including
More informationNeoadjuvant therapy a new pathway to registration?
Neoadjuvant therapy a new pathway to registration? Graham Ross, FFPM Clinical Science Leader Roche Products Ltd Welwyn Garden City, UK (full time employee) Themes Neoadjuvant therapy Pathological Complete
More informationA Study to Evaluate the Effect of Neoadjuvant Chemotherapy on Hormonal and Her-2 Receptor Status in Carcinoma Breast
Original Research Article A Study to Evaluate the Effect of Neoadjuvant Chemotherapy on Hormonal and Her-2 Receptor Status in Carcinoma Breast E. Rajesh Goud 1, M. Muralidhar 2*, M. Srinivasulu 3 1Senior
More informationTRANSPARENCY COMMITTEE OPINION. 15 February 2006
The legally binding text is the original French version TRANSPARENCY COMMITTEE OPINION 15 February 2006 Taxotere 20 mg, concentrate and solvent for solution for infusion B/1 vial of Taxotere and 1 vial
More informationLecture 5. Primary systemic therapy: clinical and biological endpoints
Lecture 5 Primary systemic therapy: clinical and biological endpoints Valentina Guarneri, M.D., Ph.D. Primary systemic therapy in breast cancer Firstly introduced d into clinical i l practice in 70s for
More informationAdjuvant Systemic Therapy in Early Stage Breast Cancer
Adjuvant Systemic Therapy in Early Stage Breast Cancer Julie R. Gralow, M.D. Director, Breast Medical Oncology Jill Bennett Endowed Professor of Breast Cancer Professor, Global Health University of Washington
More informationImpact of BMI on pathologic complete response (pcr) following neo adjuvant chemotherapy (NAC) for locally advanced breast cancer
Impact of BMI on pathologic complete response (pcr) following neo adjuvant chemotherapy (NAC) for locally advanced breast cancer Rachna Raman, MD, MS Fellow physician University of Iowa hospitals and clinics
More informationUK Interdisciplinary Breast Cancer Symposium. Should lobular phenotype be considered when deciding treatment? Michael J Kerin
UK Interdisciplinary Breast Cancer Symposium Should lobular phenotype be considered when deciding treatment? Michael J Kerin Professor of Surgery National University of Ireland, Galway and Galway University
More informationA Case Review: Treatment-Naïve Patient with Advanced NSCLC: Smoker with Metastatic Squamous Cell Tumor
Transcript Details This is a transcript of a continuing medical education (CME) activity accessible on the ReachMD network. Additional media formats for the activity and full activity details (including
More informationNew Targeted Agents Demonstrate Greater Efficacy and Tolerability in the Treatment of HER2-positive Breast Cancer
New Evidence reports on presentations given at ASCO 2012 New Targeted Agents Demonstrate Greater Efficacy and Tolerability in the Treatment of HER2-positive Breast Cancer Presentations at ASCO 2012 Breast
More informationSesiones interhospitalarias de cáncer de mama. Revisión bibliográfica 4º trimestre 2015
Sesiones interhospitalarias de cáncer de mama Revisión bibliográfica 4º trimestre 2015 Selected papers Prospective Validation of a 21-Gene Expression Assay in Breast Cancer TAILORx. NEJM 2015 OS for fulvestrant
More informationJanet E. Dancey NCIC CTG NEW INVESTIGATOR CLINICAL TRIALS COURSE. August 9-12, 2011 Donald Gordon Centre, Queen s University, Kingston, Ontario
Janet E. Dancey NCIC CTG NEW INVESTIGATOR CLINICAL TRIALS COURSE August 9-12, 2011 Donald Gordon Centre, Queen s University, Kingston, Ontario Session: Correlative Studies in Phase III Trials Title: Design
More informationResistance to anti-her2 therapies. Service d Oncologie Médicale
Resistance to anti-her2 therapies Pr David Khayat Service d Oncologie Médicale Groupe Hospitalier Pitié Salpêtrière -Paris Disclosure statment Trastuzumab in HER2+ MBC A major impact but resistance will
More informationIdeal neo-adjuvant Chemotherapy in breast ca. Dr Khanyile Department of Medical Oncology, University of Pretoria
Ideal neo-adjuvant Chemotherapy in breast ca Dr Khanyile Department of Medical Oncology, University of Pretoria When is neo-adjuvant Chemo required? Locally advanced breast ca: - Breast conservative surgery
More informationMultimedia Appendix 6 Educational Materials Table of Contents. Intervention Educational Materials Audio Script (version 1)
Multimedia Appendix 6 Educational Materials Table of Contents Intervention Educational Materials... 1 Audio Script (version 1)... 1 Text (version 1)... 5 Slides (version 1)... 17 Audio Script (version
More informationClinical Management Guideline for Breast Cancer
Initial Evaluation Clinical Stage Pre-Treatment Evaluation Treatment and pathological stage Adjuvant Treatment Less than 4 positive lymph nodes ER Positive HER2 Negative (see page 2 & 3 ) Primary Diagnosis:
More informationAnaplastic Thyroid Cancer:
1 Anaplastic Thyroid Cancer: A Doctor s Perspective for Patients and Families Living with the Disease By Maria E. Cabanillas, M.D., F.A.C.E. Associate Professor and Faculty Director of Clinical Research
More informationBreast Cancer Breast Managed Clinical Network
Initial Evaluation Clinical Stage Pre-Treatment Evaluation Treatment and pathological stage Less than 4 positive lymph nodes Adjuvant Treatment ER Positive HER2 Negative (see page 2 & 3 ) HER2 Positive
More informationChapter 5: Epidemiology of MBC Challenges with Population-Based Statistics
Chapter 5: Epidemiology of MBC Challenges with Population-Based Statistics Musa Mayer 1 1 AdvancedBC.org, Abstract To advocate most effectively for a population of patients, they must be accurately described
More informationUnderstanding and Optimizing Treatment of Triple Negative Breast Cancer
Understanding and Optimizing Treatment of Triple Negative Breast Cancer Edith Peterson Mitchell, MD, FACP Clinical Professor of Medicine and Medical Oncology Program Leader, Gastrointestinal Oncology Department
More informationMolecular subtypes in patients with inflammatory breast cancer; A single center experience
JBUON 05; 0(): 35-3 ISSN: 0-065, online ISSN: 4-63 www.jbuon.com E-mail: editorial_office@jbuon.com ORIGINAL ARTICLE Molecular subtypes in patients with inflammatory breast cancer; A single center experience
More informationBreast cancer remains the most common malignancy and the second leading. cause of cancer mortality in women in the United States.
Dr. Andrew Seidman s Commentary I. Breast Cancer Overview Breast cancer remains the most common malignancy and the second leading cause of cancer mortality in women in the United States. The following
More informationHighlights from the 2009 Annual Meeting of the American Society of Clinical Oncology
BREAST CANCER 24 Breast Cancer Highlights from the 2009 Annual Meeting of the American Society of Clinical Oncology Edited by William J. Gradishar, MD Robert H. Lurie Comprehensive Cancer Center of Northwestern
More informationMy name is Dr. David Ilson, Professor of Medicine at Memorial Sloan Kettering Cancer Center and Weill Cornell Medical Center in New York, New York.
Welcome to this CME/CE-certified activity entitled, Integrating the Latest Advances Into Clinical Experience: Data and Expert Insights From the 2016 Meeting on Gastrointestinal Cancers in San Francisco.
More informationCommon disease 175,000 new cases/year 44,000 deaths/year Less than 10% with newly diagnosed at presentation have stage IV disease Chronic disease,
Chemotherapy for Metastatic Breast Cancer: Recent Results HARMESH R. NAIK, MD. Karmanos Cancer Institute and St. Mary Hospital Metastatic breast cancer (MBC) Common disease 175,000 new cases/year 44,000
More informationBreast cancer. Prof Arlene Chan Medical Oncologist Director Breast Clinical Trials Unit, Mount Hospital Vice-Chair Breast Cancer Research Centre - WA
Breast cancer rof Arlene Chan Medical Oncologist Director Breast Clinical Trials Unit, Mount Hospital Vice-Chair Breast Cancer Research Centre - WA Breast cancer Incidence of Breast Cancer by Stage at
More informationOral Communications & Posters
Carcinoma uroteliale: Current and future directions of treatment of Muscle-Invasive Bladder cancer/ Multimodality approach of bladder cancer Oral Communications & Posters CRISTINA MASINI Oncologia Medica
More informationPage. Objectives: Hormone Therapy Resistance: Challenges and Opportunities. Research Support From Merck
Hormone Therapy Resistance: Challenges and Opportunities Pamela. N. Munster, MD University of California, San Francisco Financial Disclosures Research Support From Merck Objectives: Understanding the current
More informationPRO: Pathologic Complete Response Does Predict Outcome for Early Stage Breast Cancer Patients
PRO: Pathologic Complete Response Does Predict Outcome for Early Stage Breast Cancer Patients Amelia B. Zelnak, M.D., M.Sc. Assistant Professor of Hematology and Medical Oncology Winship Cancer Institute
More informationGene Signatures in Breast Cancer: Moving Beyond ER, PR, and HER2? Lisa A. Carey, M.D. University of North Carolina USA
Gene Signatures in Breast Cancer: Moving Beyond ER, PR, and HER2? Lisa A. Carey, M.D. University of North Carolina USA When Are Biomarkers Ready To Use? Same Rules for Gene Expression Panels Key elements
More informationPhase II Cancer Trials: When and How
Phase II Cancer Trials: When and How Course for New Investigators August 21-23, 2013 Acknowledgment Elizabeth Eisenhauer for some slides! Learning Objectives At the end of the session the participant should
More informationTriple Negative Breast Cancer: Part 2 A Medical Update
Triple Negative Breast Cancer: Part 2 A Medical Update April 29, 2015 Tiffany A. Traina, MD Breast Medicine Service Memorial Sloan Kettering Cancer Center Weill Cornell Medical College Overview What is
More informationEGFR as paradoxical predictor of chemosensitivity and outcome among triple-negative breast cancer
ONCOLOGY REPORTS 21: 413-417, 2009 413 EGFR as paradoxical predictor of chemosensitivity and outcome among triple-negative breast cancer HIROKO NOGI 1, TADASHI KOBAYASHI 2, MASAFUMI SUZUKI 3, ISAO TABEI
More informationClinical and pathological portraits of axillary presentation breast cancer and effects of preoperative systemic therapy
Case Series Clinical and pathological portraits of axillary presentation breast cancer and effects of preoperative systemic therapy Ling Xu 1*, Fang Li 1,2*, Yinhua Liu 1, Xuening Duan 1, Jingming Ye 1,
More informationNational Horizon Scanning Centre. Bevacizumab (Avastin) in combination with non-taxanes for metastatic breast cancer - first line therapy
Bevacizumab (Avastin) in combination with non-taxanes for metastatic breast cancer - first line therapy December 2007 This technology summary is based on information available at the time of research and
More informationXII Michelangelo Foundation Seminar
XII Michelangelo Foundation Seminar The opportunity of the neoadjuvant approach L. Gianni, Milan, I XII Michelangelo Foundation Seminar Milano, October 12, 2012 The opportunity of the neoadjuvant approach
More informationSustained benefits for women with HER2-positive early breast cancer JORGE MADRID BIG GOCCHI PROTOCOLO HERA
Sustained benefits for women with HER2-positive early breast cancer JORGE MADRID BIG GOCCHI PROTOCOLO HERA The fascinating history of Herceptin 1981 1985 1987 1990 1992 1998 2000 2005 2006 2008 2011 Murine
More informationNadia Harbeck Breast Center University of Cologne, Germany
Evidence in Favor of Taxane Based Combinations and No Anthracycline in Adjuvant and Metastatic Settings Nadia Harbeck Breast Center University of Cologne, Germany Evidence in Favor of Taxane Based Combinations
More informationChemotherapy With or Without Targeted Drugs* in Metastatic Breast Cancer
Diagnosis and Treatment of Patients with Primary and Metastatic Breast Cancer Chemotherapy With or Without Targeted Drugs* in Metastatic Breast Cancer * Substances without published evidence based on at
More informationResults of the ACOSOG Z0011 Trial
DCIS and Early Breast Cancer Symposium JUNE 15-17 2012 CAPPADOCIA Results of the ACOSOG Z0011 Trial Kelly K. Hunt, M.D. Professor of Surgery Axillary Node Dissection Staging, Regional control, Survival
More informationBreast : ASCO Abstracts for Review
Breast : ASCO 2011 Susana Campos, MD, MPH Dana Farber Cancer Institute Abstracts for Review Prevention Neoadjuvant Metastatic Brain mets LBA 504: Exemestane for primary prevention of breast cancer in postmenopausal
More informationMaram Abdaljaleel, MD Dermatopathologist and Neuropathologist University of Jordan, School of Medicine
Maram Abdaljaleel, MD Dermatopathologist and Neuropathologist University of Jordan, School of Medicine The most common non-skin malignancy of women 2 nd most common cause of cancer deaths in women, following
More informationNovel Preoperative Therapies for HER2-Positive Breast Cancer. Debu Tripathy, MD University of Southern California Norris Comprehensive Cancer Center
Novel Preoperative Therapies for HER2-Positive Breast Cancer Debu Tripathy, MD University of Southern California Norris Comprehensive Cancer Center Key Findings to Date in the Neoadjuvant Therapy of HER2+
More informationPhase II Cancer Trials: When and How
Phase II Cancer Trials: When and How Course for New Investigators August 9-12, 2011 Learning Objectives At the end of the session the participant should be able to Define the objectives of screening vs.
More informationBreast Cancer? Breast cancer is the most common. What s New in. Janet s Case
Focus on CME at The University of Calgary What s New in Breast Cancer? Theresa Trotter, MD, FRCPC Breast cancer is the most common malignancy affecting women in Canada, accounting for almost a third of
More informationA Case Review: Treatment-Naïve Patient with Head and Neck Cancer
Transcript Details This is a transcript of a continuing medical education (CME) activity accessible on the ReachMD network. Additional media formats for the activity and full activity details (including
More informationFDA Briefing Document Oncologic Drugs Advisory Committee Meeting. September 12, sbla /51 Pertuzumab (PERJETA ) Applicant: Genentech, Inc.
/51 FDA Briefing Document Oncologic Drugs Advisory Committee Meeting September 12, 2013 /51 Pertuzumab (PERJETA ) Applicant: Genentech, Inc. Disclaimer: The attached package contains background information
More informationNEOADJUVANT THERAPY FOR BREAST CANCER: LOCAL EXPERT OPINION AND RECENT EVIDENCE
NEOADJUVANT THERAPY FOR BREAST CANCER: LOCAL EXPERT OPINION AND RECENT EVIDENCE Dr. Joanne Chiu Medical Oncology Queen Mary Hospital The University of Hong Kong HONG KONG SURVEY FOR NEOADJUVANT THERAPY
More informationUpdate in the treatment of Her2- overexpressing breast cancers. Fabrice ANDRE Institut Gustave Roussy Villejuif, France
Update in the treatment of Her2- overexpressing breast cancers Fabrice ANDRE Institut Gustave Roussy Villejuif, France Questions Should tumors
More informationbreast and OVARIAN cancer
breast and OVARIAN cancer DR DAVID FENNELLY CONSULTANT MEDICAL ONCOLOGIST ST VINCENT S UNIVERSITY HOSPITAL DUBLIN HOW RELEVANT IS ONCOLOGY IN MEDICINE TODAY? Cancer is the second leading cause of death
More informationmajority of the patients. And taking an aggregate of all trials, very possibly has a modest effect on improved survival.
Hello. I am Farshid Dayyani. I am Assistant Professor in Genitourinary Medical Oncology at The University of Texas MD Anderson Cancer Center. We will be talking today about prostate cancer for survivorship
More informationInvasive Breast Cancer
Invasive Breast Cancer Eileen Rakovitch MD MSc FRCPC Sunnybrook Health Sciences Centre Medical Director, Louise Temerty Breast Cancer Centre LC Campbell Chair in Breast Cancer Research Associate Professor,
More informationImplications of Progesterone Receptor Status for the Biology and Prognosis of Breast Cancers
日大医誌 75 (1): 10 15 (2016) 10 Original Article Implications of Progesterone Receptor Status for the Biology and Prognosis of Breast Cancers Naotaka Uchida 1), Yasuki Matsui 1), Takeshi Notsu 1) and Manabu
More informationCover Page. The handle holds various files of this Leiden University dissertation
Cover Page The handle http://hdl.handle.net/1887/55957 holds various files of this Leiden University dissertation Author: Dekker T.J.A. Title: Optimizing breast cancer survival models based on conventional
More informationChemotherapy for Isolated Locoregional Recurrence
Chemotherapy for Isolated Locoregional Recurrence Michelle Melisko MD Assistant Clinical Professor UCSF Helen Diller Family Comprehensive Cancer Center MBC and Improved Median Survival with New Therapies
More informationNational Horizon Scanning Centre. Sunitinib (Sutent) for advanced and/or metastatic breast cancer. December 2007
Sunitinib (Sutent) for advanced and/or metastatic breast cancer December 2007 This technology summary is based on information available at the time of research and a limited literature search. It is not
More informationThe next wave of successful drug therapy strategies in HER2-positive breast cancer. Hans Wildiers University Hospitals Leuven Belgium
The next wave of successful drug therapy strategies in HER2-positive breast cancer Hans Wildiers University Hospitals Leuven Belgium Trastuzumab in 1st Line significantly improved the prognosis of HER2-positive
More informationCirculating tumor cells as biomarker for hormonal treatment in breast and prostate cancer. Michal Mego
National Cancer Institute, Slovakia Translational Research Unit Circulating tumor cells as biomarker for hormonal treatment in breast and prostate cancer Michal Mego 2 nd Department of Oncology, Faculty
More informationJosé Baselga, MD, PhD
i n t e r v i e w José Baselga, MD, PhD Dr Baselga is Physician-in-Chief at Memorial Sloan-Kettering Cancer Center in New York, New York. Tracks 1-15 Track 1 Track 2 Track 3 Track 4 Track 5 Track 6 Track
More informationMaria João Cardoso, MD, PhD
Locally Advanced Breast Cancer Specific Issues in LocorregionalTreatment Surgery, MD, PhD Head Breast Surgeon Breast Unit, Champalimaud Foundation Lisbon, Portugal 1 Conflict of Interest Disclosure No
More informationExosomal Del 1 as a potent diagnostic marker for breast cancer : A prospective cohort study
GBCC 2017: ABS-0017 Exosomal Del 1 as a potent diagnostic marker for breast cancer : A prospective cohort study Soo Jung Lee 1, Jeeyeon Lee 2, Jin Hyang Jung 2, Ho Yong Park 2, Chan Hyeong Lee 3, Pyong
More informationBest of San Antonio 2008
Best of San Antonio 2008 Ellie Guardino, MD/PhD Assistant Professor Stanford University BIG 1 98: a randomized double blind phase III study evaluating letrozole and tamoxifen given in sequence as adjuvant
More informationInes Buccimazza 16 TH UP CONTROVERSIES AND PROBLEMS IN SURGERY SYMPOSIUM
BILATERAL MASTECTOMY IS NOT ROUTINELY JUSTIFIED IN PATIENTS WITH BILATERAL AXILLARY LYMPHADENOPATHY AND ONLY ONE DETECTABLE PRIMARY BREAST CANCER LESION SURGERY SYMPOSIUM Ines Buccimazza Breast Unit Department
More informationNATIONAL INSTITUTE FOR HEALTH AND CLINICAL EXCELLENCE. Health Technology Appraisal
NATIONAL INSTITUTE FOR HEALTH AND CLINICAL EXCELLENCE Health Technology Appraisal Trastuzumab, as monotherapy and in combination with a taxane, for the treatment of metastatic breast cancer (to include
More informationPregnancy in the middle of adjuvant treatment of Her2 positive breast cancer
ESMO Preceptorship Programme ESMO Preceptorship ADOLESCENTS & YOUNG ADULTS MALIGNANCIES Lugano, Switzerland 11-12 May 2018 Petra Vuković, University Hospital for Tumors, University Hospital Center Sestre
More informationState of the Science: Current status of research relevant to GCT GCT Survivors Weekend April 16, 2011
State of the Science: Current status of research relevant to GCT GCT Survivors Weekend April 16, 2011 Jubilee Brown, M.D. Associate Professor UT M.D. Anderson Cancer Center Ovarian Cancer 21,880 new cases
More informationBreast Cancer: Who Gets It? Who Survives? The Latest Information
Breast Cancer: Who Gets It? Who Survives? The Latest Information James J. Stark, MD, FACP Medical Director, Cancer Program and Director of Palliative Care Maryview Medical Center Professor of Medicine
More informationInterviews are based on data presented at the 2012 American Society of Clinical Oncology Annual Meeting, June 1-5, 2012, Chicago, Illinois* *PeerVoice is an independent publisher of conference news and
More informationNEWER DRUGS IN HEAD AND NECK CANCER. Prof. Anup Majumdar. HOD, Radiotherapy, IPGMER Kolkata
NEWER DRUGS IN HEAD AND NECK CANCER Prof. Anup Majumdar HOD, Radiotherapy, IPGMER Kolkata 1 Included Oral cavity Nasal cavity Pharynx Larynx Lymph node in upper part of neck Excluded Brain Eye Cancer arising
More informationHow to Use MRI Following Neoadjuvant Chemotherapy (NAC) in Locally Advanced Breast Cancer
Global Breast Cancer Conference 2016 & 5 th International Breast Cancer Symposium April 29 th 2016, 09:40-10:50 How to Use MRI Following Neoadjuvant Chemotherapy (NAC) in Locally Advanced Breast Cancer
More informationAnaplastic Thyroid Cancer:
1 Anaplastic Thyroid Cancer: A Doctor s Perspective for Patients and Families Living with the Disease By Maria E. Cabanillas, M.D., F.A.C.E. Associate Professor and Faculty Director of Clinical Research
More information