Curriculum Vitae. Brent S. Rose, M.D.

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1 Curriculum Vitae Brent S. Rose, M.D. Department of Radiation Medicine and Applied Sciences University of California San Diego 3855 Health Sciences Dr., MC 0843 La Jolla, CA, Phone: (858) Fax: (858) Education University of California, San Diego, 7/2002 to 6/2005 Degree: B.S. in Biology University of California, San Diego, School of Medicine 8/2005 to 6/2010 Degree: M.D. in Medicine NIH-Sponsored Research Fellowship 12/2008 to 12/2009 Mentor: Loren K. Mell, M.D. Associate Professor Department of Radiation Medicine University of California, San Diego, School of Medicine Post-Doctoral Research Fellowship 6/2010 to 7/2011 Mentor: Loren K. Mell, M.D. Associate Professor Department of Radiation Medicine University of California, San Diego, School of Medicine Post-Graduate Training Beth Israel Deaconess Medical Center, Internal Medicine 7/2011 to 6/2012 Program Director: Eileen Reynolds, M.D. Harvard Radiation Oncology Program 7/2012 to 6/2016 Chairman and Program Director: Jay R. Harris, M.D. Licensure Licensed, Physician and Surgeon, State of California 6/2016 to present 1 of 7

2 Academic Employment Assistant Professor Department of Radiation Medicine and Applied Sciences University of California San Diego, La Jolla, CA 6/2016 to present Honors and Awards Phi Beta Kappa Honor Society 2005 Gold Humanism Honor Society 2008 Arlene J. and Dr. Bernard Goodhead Service Award in Oncology 2010 William Shipley Research Award 2015 Funding Active UCSD Department of Radiation Medicine and Applied Sciences $150,000 Image-Guided Radiation Therapy for Prostate Cancer Major Goals: To develop protocols for simultaneous integrated boost IMRT in the treatment of prostate cancer Completed National Institute of Health T32 Research Fellowship Grant $30,000 Peer Reviewed Publications 1. Rose BS, Chen MH, Wu J, et al. Androgen Deprivation Therapy Use in the Setting of High-dose Radiation Therapy and the Risk of Prostate Cancer Specific Mortality Stratified by the Extent of Competing Mortality. Int J Radiat Oncol Biol Phys. 2016;96: Muralidhar V, Rose BS, Chen YW, Nezolosky MD, Nguyen PL. Association Between Travel Distance and Choice of Treatment for Prostate Cancer: Does Geography Reduce Patient Choice? Int J Radiat Oncol Biol Phys. 2016;96: Rose BS, Jee KW, Niemierko A, Murphy JE, Blaszkowsky LS, Allen JN, Lee LK, Wang Y, Drapek LC, Hong TS, Wo JY. Irradiation of FDG-PET Defined Active Bone Marrow Subregions and Acute Hematologic Toxicity in Anal Cancer Patients Undergoing Chemoradiation. Int J Radiat Oncol Biol Phys. 2016;94: Rose BS, Jiang W, Punglia RS. Effect of Lymph Node Metastasis Size on Breast Cancer-Specific and Overall Survival in Women with Node-Positive Breast Cancer. Breast Cancer Res Treat. 2015;152: Zakeri K, Rose BS, D'Amico AV, Jeong JH, Mell LK. Competing events and costs of clinical trials: Analysis of a randomized trial in prostate cancer. Radiother Oncol. 2015;S : of 7

3 6. Carmona R, Gulaya S, Murphy JD, Rose BS, Wu J, Noticewala S, McHale MT, Yashar CM, Vaida F, Mell LK. Validated competing event model for the stage I-II endometrial cancer population. Int J Radiat Oncol Biol Phys. 2014;89: Rose BS, Chen MH, Zhang D, Hirsch MS, Richie JP, Chang SL, Hegde JV, Loffredo MJ, D'Amico AV. Maximum Tumor Diameter and the Risk of PSA Failure after Radical Prostatectomy. Clin Genitourin Cancer. 2014;12:e Pan H, Rose BS, Simpson DR, Mell LK, Mundt AJ, Lawson JD. Clinical Practice Patterns of Lung Stereotactic Body Radiation Therapy in the United States: A Secondary Analysis. Am J Clin Oncol. 2013;36: Jensen LG, Hasselle MD, Rose BS, Nath SK, Hasan Y, Scanderbeg DJ, Yashar CM, Mundt AJ, Mell LK. Outcomes for patients with cervical cancer treated with extended-field intensitymodulated radiation therapy and concurrent cisplatin. Int J Gynecol Cancer. 2013; 23: Waters JD, Rose B, Gonda DD, Scanderbeg DJ, Russell M, Alksne JF, Murphy K, Carter BS, Lawson J, Chen CC. Immediate post-operative brachytherapy prior to irradiation and temozolomide for newly diagnosed glioblastoma. J Neurooncol Jul; 113(3): Zakeri K, Rose BS, Gulaya S, D'Amico AV, Mell LK. Competing event risk stratification may improve the design and efficiency of clinical trials: secondary analysis of SWOG Contemp Clin Trials. 2013; 34: Liang Y, Bydder M, Yashar CM, Rose BS, Cornell M, Hoh CK, Lawson JD, Einck J, Saenz C, Fanta P, Mundt AJ, Bydder GM, Mell LK. Prospective study of functional bone marrow-sparing intensity modulated radiation therapy with concurrent chemotherapy for pelvic malignancies. Int J Radiat Oncol Biol Phys. 2013; 85: Rose BS, Liang Y, Lau SK, Jensen LG, Yashar CM, Hoh CK, Mell LK. Correlation Between Radiation Dose to 18 F-FDG-PET Defined Active Bone Marrow Subregions and Acute Hematologic Toxicity in Cervical Cancer Patients Treated with Chemoradiotherapy. Int J Radiat Oncol Biol Phys. 2012; 83: Mell LK, Lau SK, Rose BS, Jeong JH. Reporting of Cause-Specific Treatment Effects in Cancer Clinical Trials with Competing Risks: A Systematic Review. Contemp Clin Trials. 2012; 33: Simpson DR, Song WY, Moiseenko V, Rose BS, Yashar CM, Mundt AJ, Mell LK. Normal tissue complication probability analysis of acute gastrointestinal toxicity in cervical cancer patients undergoing intensity modulated radiation therapy and concurrent cisplatin. Int J Radiat Oncol Biol Phys. 2012; 83: e Rose BS, Jeong JH, Nath SK, Lu SM, Mell LK. Population-based study of competing mortality in head and neck cancer. J Clin Oncol. 2011; 29: See Editorial: Manola JB, Gray RJ. When bad things happen to good studies. J Clin Oncol ; 29: of 7

4 17. Nath SK, Carmona R, Rose BS, Simpson DR, Russell M, Lawson JD, Mundt AJ, Murphy KT. Observed magnetic resonance imaging changes in pediatric patients treated with stereotactic radiosurgery for intracranial tumors. Childs Nerv Syst. 201; 27: Hasselle MD, Rose BS, Kochanski JD, Nath SK, Bafana R, Yashar CM, Hasan Y, Roeske JC, Mundt AJ, Mell LK. Clinical Outcomes of Intensity Modulated Radiation Therapy for Carcinoma of the Cervix. Int J Radiat Oncol Biol Phys. 2011;80(5): Liang Y, Messer K, Rose BS, Lewis J, Jiang S, Yashar C, Mundt A, Mell L. Impact of Bone Marrow Radiation Dose on Acute Hematologic Toxicity in Cervical Cancer: Principal Component Analysis on High Dimensional Data. Int J Radiat Oncol Biol Phys. 2010; 78(3): Simpson DR, Lawson JD, Nath SK, Rose BS, Mundt AJ, Mell LK. A Survey of Image-Guided Radiotherapy use for In-Room Setup among U.S. Radiation Oncologists. Cancer. 2010; 116(16): Rose BS, Aydogan B, Liang Y, Yeginer M, Hasselle MD, Dandekar V, Bafana R, Yashar CM, Mundt AJ, Roeske JC, Mell LK. Normal Tissue Complication Probability Modeling of Acute Hematologic Toxicity in Cervical Cancer Patients Treated with Chemoradiotherapy. Int J Radiat Oncol Biol Phys. 2011; 79: Nath SK, Sandhu AP, Rose BS, Simpson DR, Nobiensky PD, Wang JZ, Millard F, Kane CJ, Parsons JK, Mundt AJ. Toxicity Analysis of Post-Operative Image-Guided Intensity-Modulated Radiotherapy for Prostate Cancer. Int J Radiat Oncol Biol Phys. 2010; 78: Simpson DR, Lawson JD, Nath SK, Rose BS, Mundt AJ, Mell LK. Utilization of Advanced Imaging Technologies for Target Delineation in Radiation Oncology. J Am Coll of Radiol. 2009; 6: Commentaries and Invited Reviews 1. Rose BS, Winer EP, Mamon HJ. Perils of the Pathologic Complete Response. J Clin Oncol Aug 22 (E-published ahead of print). 2. Viswanathan AN, Lee LJ, Eswara JR, Horowitz NS, Konstantinopoulos PA, Mirabeau-Beale KL, Rose BS, Keudell AG, Wo JY. Complications of pelvic radiation in patients treated for gynecologic malignancies. Cancer. 2014;120: Mell LK, Zakeri K, Rose, BS. On Lumping, Splitting, and the Nosology of Clinical Trial Populations and End Points. J Clin Oncol. 2014;32: Nath SK, Simpson DR, Rose BS, Sandhu AP. Recent Advances in Image-Guided Radiotherapy for Head and Neck Carcinoma. J Oncol. 2009; 2009: Rose BS, Simpson DR, Nath SK, Mundt AJ. Hypofractionated Radiotherapy in the Elderly: Sometimes Less is More. Aging Health. 2009; 5: of 7

5 Textbook Chapters 1. Jensen LG, Rose BS, Mundt AJ. Neutropenia. In: Encyclopedia of Radiation Oncology. Brady LW and Yaeger T (editors). Springer, Berlin Jensen LG, Rose BS, Mundt AJ, Oliai. Hemotopoiesis. In: Encyclopedia of Radiation Oncology. Brady LW and Yaeger T (editors). Springer, Berlin Simpson DR, Nath SK, Rose BR, Mundt AJ. Adaptive Radiotherapy: Physician's Perspective. In: Image Guided-Radiotherapy: A Clinical Perspective. Mundt AJ and Roeske JC (editors). B.C. Decker, Toronto Yashar CM, Rose BS, Scanderbeg DJ. Daily On-Line Planar and Volumetric-based Patient Setup and Tumor Localization in a Stage IIB Cervical Cancer Patient Using the Varian Trilogy Machine. In: Image Guided-Radiotherapy: A Clinical Perspective. Mundt AJ and Roeske JC (editors). B.C. Decker, Toronto Refereed Conference Proceedings 1. Carmona R, Zakeri K, Green G, Hwang L, Gulaya S, Xu B, Verma R, Williamson, CW, Triplett DP, Rose BS. Shen H, Vaida F, Murphy JD, Mell LK. Improved Method to Stratify Elderly Patients With Cancer at Risk for Competing Events. J Clin Oncol. 2016;JCO Rose BS, Jee KW, Niemierko A, et al. Irradiation of FDG-PET Defined Active Bone Marrow Subregions and Acute Hematologic Toxicity in Anal Cancer Patients Undergoing Chemoradiation. Int J Radiat Oncol Biol Phys. 2015;93(3);E Giantsoudi D, Jee K, Rose BS, MacDonald S, and Paganetti H. Proton Radiation Therapy for Left- Sided Breast Cancer: LET and RBE Considerations for Cardiac Toxicity. Med Phys. 2015;42(6): Rose BS, Chen MH, Zhang D, et al. Maximum Tumor Diameter and the Risk of PSA Failure after Radical Prostatectomy. J Urology. 2014;191(4):e Rose BS, Jiang W, Punglia RS. Effect of Involved Lymph Node Size on Cancer-Specific Mortality in Women With Node-Positive Breast Cancer. Int J Radiat Oncol Biol Phys. 2014; 90(1):S Rose BS, Zakeri K, Gulaya S, et al. Competing event risk stratification may improve the design and efficiency of clinical trials: Secondary analysis of SWOG J Clin Oncol. 2012; 30(15):JCO Zakeri K, Rose BS, and Mell LK. Improving the efficiency of clinical trials through selection models. Int J Radiat Oncol Biol Phys. 2012;84(3);S Rose BS, Liang Y, Lau SKM, Yashar CM, and Mell LK. Correlation between Radiation Dose to FDG-PET Defined Active Bone Marrow Sub-regions and Acute Hematologic Toxicity in Cervical Cancer Patients Treated with Chemoradiotherapy. Int J Radiat Oncol Biol Phys. 2011;81(2):S186- S of 7

6 9. Pan H, Rose BS, Simpson DR, et al. A Survey of Lung Stereotactic Body Radiation Therapy (SBRT) Practice Patterns in the United States. Int J Radiat Oncol Biol Phys. 2011;81(2):S Pan H, Rose BS, Simpson DR, et al. A Survey of Spine Stereotactic Body Radiation Therapy Practice Patterns in the United States. Int J Radiat Oncol Biol Phys. 2011;81(2):S293-S Pan H, Rose BS, Simpson DR, et al. A Survey of Liver Stereotactic Body Radiation Therapy Practice Patterns in the United States. Int J Radiat Oncol Biol Phys. 2011:81(2): S360-S Rose BS, Nath SK, Lu S, and Mell LK. Competing mortality in advanced head and neck cancer: A population-based study. J Clin Oncol. 2010;28(15):s Simpson DR, Song WY, Rose BS, et al. Normal Tissue Complication Probability Analysis of Acute Gastrointestinal Toxicity in Cervical Cancer Patients Undergoing Intensity Modulated Radiation Therapy and Concurrent Cisplatin. Int J Radiat Oncol Biol Phys. 2010;78(3):S141-S Rose BS, Nath SK, Manoj S et al. Correlation between Bone Marrow Dose and Acute Hematologic Toxicity in Cervical Cancer Patients Treated with Chemoradiotherapy: Implications for Extended-Field Intensity Modulated Radiation Therapy. Int J Radiat Oncol Biol Phys. 2010;78(3):S Mundt AJ, Simpson DR, Nath SK, Rose BS, Mell LK. Portrayal of Radiation Therapy in the Press: A Survey of American Newspapers. Int J Radiat Oncol Biol Phys. 2010;78(3):S Rose BS, Scanderbeg DJ, Lawson JD, et al. Initial Clinical Experience with High-Dose Rate Intracavitary Brachytherapy Using the MammoSite and Contura Devices for the Treatment of High-Grade Glioma. Brachytherapy. 2010;9:S85-S Nath SK, Rose BS, Simpson DR, et al. Observed Radiographic Changes in Pediatric Patients Treated with Frameless Stereotactic Radiosurgery for Intracranial Tumors. Int J Radiat Oncol Biol Phys. 2010;78(3):S Lau SK, Rose BS, Mell LK. Reporting of Disease-specific Treatment Effects in Randomized Controlled Trials: Systematic Review and Analysis of the Medical Literature. Int J Radiat Oncol Biol Phys. 2010;78(3):S Rose BS, Lawson JD, Zhu H, et al. Intracavitary Brachytherapy with the GliaSite or MammoSite Devices as a Component of the Initial Treatment of Glioblastoma Multiforme. Brachytherapy. 2010;9:S71-S Rose BS, Aydogan B, Yeginer M et al. Normal tissue complication probability modeling of acute hematologic toxicity in cervical cancer patients treated with chemoradiotherapy. Int J Radiat Oncol Biol Phys. 2009;75(3):S Lawson JD, Simpson DR, Rose BS et al. Adaptive Radiotherapy in Cervical Cancer: Dosimetric Analysis using Daily Cone-beam CT. Int J Radiat Oncol Biol Phys. 2009;75(3):S85-S86. 6 of 7

7 22. Liang Y, Rose BS, Lewis J et al. Investigating Effects of Pelvic Bone Marrow Radiation Dose on Acute Hematologic Toxicity Using High Dimensional Data Analysis. Med Phys. 2009; 36(6): Liang Y, Rose BS, Lewis J, et al. Modeling Effects of 3D Pelvic Bone Marrow Radiation Dose on Acute Hematologic Toxicity using Principal Components Analysis. Int J Radiat Oncol Biol Phys. 2009;75(3):S Simpson DR, Lawson JD, Nath SK, Rose BS, Mundt AJ, Mell LK. Survey of Image-guided Radiation Therapy use in the United States. Int J Radiat Oncol Biol Phys. 2009;75(3):S Sandhu A, Nath SK, Rose BS, et al. Post-operative Image-guided Intensity-modulated Radiation Therapy for Prostate Cancer: Acute and Late Gastrointestinal and Genitourinary Toxicity. Int J Radiat Oncol Biol Phys. 2009;75(3):S Hasselle MD, Kochanski JD, Rose BS, et al. Clinical Outcomes of Intensity Modulated Radiation Therapy for Carcinoma of the Cervix: A Multi-institutional Analysis. Int J Radiat Oncol Biol Phys. 2009;75(3):S of 7

8/2/2012. Mapping Anatomically Sensitive Bone Marrow Regions. Hematopoietic Functions of Bone Marrow. Radiosensitivity of Bone Marrow

8/2/2012. Mapping Anatomically Sensitive Bone Marrow Regions. Hematopoietic Functions of Bone Marrow. Radiosensitivity of Bone Marrow Mapping Anatomically Sensitive Bone Marrow Regions Loren K. Mell, M.D. Center for Advanced Radiotherapy Technologies University of California San Diego July 31, 2012 Hematopoietic Functions of Bone Marrow