Overview of this case:
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- Ferdinand Eaton
- 5 years ago
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1 Overview of this case:
2 Overview of this case:
3 Overview of this case:
4 Overview of this case:
5 Not the first lawsuit:
6 How the trial works: 1. Opening statements 2. Plaintiff s case 3. Monsanto s case 4. Rebuttal (possible) 5. Closing arguments 6. Deliberations
7 Current & Former Employees
8 Current & Former Employees Dr. Donna Farmer Product Protection Lead Dr. Daniel Goldstein Medical Sciences and Outreach Dr. William Heydens Product Safety Assessment Strategy Lead
9 Current & Former Employees
10 Current & Former Employees Dr. Mark Martens Toxicology Director (former) Dr. David Saltmiras Toxicology Manager Dr. John Acquavella Epidemiologist (former)
11 Current & Former Employees
12 Current & Former Employees Daniel Jenkins Manager for Regulatory Affairs David Heering Strategy, Compliance, Operations Lead
13 Current & Former Employees
14 Current & Former Employees Steve Gould National Accounts Manager (includes California) Dr. Kirk Azevedo Sales Representative (former)
15 Opening Statement Roadmap: 1. What is Roundup? 2. Can Roundup cause cancer? 3. Did Roundup cause Mr. Johnson s cancer? 4. What are Mr. Johnson s damages? 5. Should Monsanto be punished for its conduct?
16 Opening Statement Roadmap: 1. What is Roundup? 2. Can Roundup cause cancer? 3. Did Roundup cause Mr. Johnson s cancer? 4. What are Mr. Johnson s damages? 5. Should Monsanto be punished for its conduct?
17 1. What is Roundup?
18 1. What is Roundup?
19 1. What is Roundup? Glyphosate
20 1. What is Roundup? Surfactant POlyEthoxylated tallow Amine
21 1. What is Roundup? Surfactant POEA
22 1. What is Roundup? POEA Without Surfactant With Surfactant
23 1. What is Roundup? Penetrates the surface of a leaf, but also human skin POEA POEA
24 1. What is Roundup?
25 1. What is Roundup?
26 1. What is Roundup?
27 1. What is Roundup?
28 Opening Statement Roadmap: 1. What is Roundup? 2. Can Roundup cause cancer? 3. Did Roundup cause Mr. Johnson s cancer? 4. What are Mr. Johnson s damages? 5. Should Monsanto be punished for its conduct?
29 Opening Statement Roadmap: 1. What is Roundup? 2. Can Roundup cause cancer? 3. Did Roundup cause Mr. Johnson s cancer? 4. What are Mr. Johnson s damages? 5. Should Monsanto be punished for its conduct?
30 2. Can Roundup cause cancer? Three Pillars of Cancer Science 1. Animal Carcinogenicity Studies 2. Mechanistic Data 3. Epidemiology
31 Plaintiff s Experts Christopher Portier, PhD. Ph.D. in Biostatistics, University of North Carolina School of Public Health (1981). Thesis addressed the best way to design a twoyear rodent study to assess the ability of a chemical to cause cancer. Former Associate Director of the National Toxicology Program (NTP) Former Associate Director of National Institutes of Health Former Director of the National Center for Environmental Health (NCEH) at the Centers for Disease Control and Prevention (CDC) Former Director of the Agency for Toxic Substances and Disease Registry (ATSDR)
32 Plaintiff s Experts Alfred Neugut, M.D., PhD. Professor of Cancer Research and Professor of Medicine and Epidemiology at Columbia University Director of Junior Faculty Development for the Department of Epidemiology at Columbia University Medical oncologist with a Ph.D. in Pathology (1977) and M.P.H. in Epidemiology (1983) from the University of Columbia Published over 500 peer reviewed chapters and papers and received over $50 million in funding from the National Cancer Institute, American Cancer Society, and Department of Defense
33 2. Can Roundup cause cancer? Three Pillars of Cancer Science 1. Animal Carcinogenicity Studies 2. Mechanistic Data 3. Epidemiology
34 2. Can Roundup cause cancer? Three Pillars of Cancer Science 1. Animal Carcinogenicity Studies 2. Mechanistic Data 3. Epidemiology
35 2. Can Roundup cause cancer? 1. Animal Carcinogenicity Studies Long term typically, 2 years Control Low Dose Mid Dose High Dose Significant increases in tumors Replication Dose response Cross-species Rare tumors Glyphosate only
36 2. Can Roundup cause cancer? 1. Animal Carcinogenicity Studies Admission No. 7 Monsanto admits that it did not conduct Long term typically, 2 years Control Low Dose Mid Dose High Dose Significant increases in tumors Replication Dose response Cross-species Rare tumors Glyphosate only any further long-term carcinogenicity animal studies after 1991.
37 2. Can Roundup cause cancer? 1. Animal Carcinogenicity Studies
38 2. Can Roundup cause cancer? 1. Animal Carcinogenicity Studies
39 2. Can Roundup cause cancer? 1. Animal Carcinogenicity Studies
40 2. Can Roundup cause cancer? 1. Animal Carcinogenicity Studies
41 2. Can Roundup cause cancer? 1. Animal Carcinogenicity Studies George Study (2010) Applied to skin 3x week 40% of mice exposed to glyphosate had tumors in skin 0% of control group had tumors in skin Evidence that glyphosate is a tumor promoter
42 2. Can Roundup cause cancer? 1. Animal Carcinogenicity Studies Long term typically, 2 years Control Low Dose Mid Dose High Dose Significant increases in tumors Replication Dose response Cross-species Rare tumors Glyphosate only
43 2. Can Roundup cause cancer? 1. Animal Carcinogenicity Studies
44 2. Can Roundup cause cancer? 1. Animal Carcinogenicity Studies
45 2. Can Roundup cause cancer? 1. Animal Carcinogenicity Studies
46 2. Can Roundup cause cancer? 1. Animal Carcinogenicity Studies
47 2. Can Roundup cause cancer? Three Pillars of Cancer Science 1. Animal Carcinogenicity Studies 2. Mechanistic Data 3. Epidemiology
48 2. Can Roundup cause cancer? Three Pillars of Cancer Science 1. Animal Carcinogenicity Studies 2. Mechanistic Data 3. Epidemiology
49 2. Can Roundup cause cancer? 2. Mechanistic Data Mechanistic Data: Refers to the way in which a substance can cause cancer.
50 2. Can Roundup cause cancer? 2. Mechanistic Data Genotoxicity: The property of chemical agents that damage the genetic information within a cell that can cause mutations. Oxidative Stress: An imbalance between the production of free oxygen particles and the ability of the body to counteract their harmful effects with antioxidants.
51 2. Can Roundup cause cancer? 2. Mechanistic Data
52 2. Can Roundup cause cancer? 2. Mechanistic Data Different methods of testing DNA damage Over 100 different studies Both Roundup & glyphosate In humans (vivo & vitro) Non-human mammals (vivo & vitro) Non-mammals (vivo & vitro) In vivo: In a living organism. In vitro: In glass, as in a test tube.
53 2. Can Roundup cause cancer? 2. Mechanistic Data In the 1990 s four published genotoxicity studies Rank, Bolognesi, Lioi, & Peluso prompted Monsanto to hire an independent genotox expert
54 Jan 1992 Rank study shows that Roundup exposure, as opposed to glyphosate alone, causes elevated increases of DNA damage.
55 Jan 1992 Rank study shows that Roundup exposure, as opposed to glyphosate alone, causes elevated increases of DNA damage. Mar 1997 Bolognesi study shows that Roundup formulation causes genetic damage in human cells.
56 Jan 1998 Rank study shows that Roundup exposure, as opposed to glyphosate alone, causes elevated increases of DNA damage. Mar 1997 Bolognesi study shows that Roundup formulation causes genetic damage in human cells.
57 Jan 1998 Rank study shows that Roundup exposure, as opposed to glyphosate alone, causes elevated increases of DNA damage. Mar 1997 Bolognesi study shows that Roundup formulation causes genetic damage in human cells.
58 Jan 1992 Rank study shows that Roundup exposure, as opposed to glyphosate alone, causes elevated increases of DNA damage. Mar 1997 Bolognesi study shows that Roundup formulation causes genetic damage in human cells.
59 Jul 1998 Lioi study shows that glyphosate induces cell stress in animal cells.
60 Dec 1998 Peluso study shows that Roundup exposure induces dose dependent DNA damage in mice. Jul 1998 Lioi study shows that glyphosate induces cell stress in animal cells.
61 Dec 1998 Peluso study shows that Roundup exposure induces dose dependent DNA damage in mice. Jul 1998 Lioi study shows that glyphosate induces cell stress in animal cells. Dec 1998 Monsanto s Reaction: Need to hire an expert to refute these studies, so Monsanto reaches out to Dr. James Parry.
62 Dec 1998 Mechanistic: Peluso study shows that Roundup exposure induces dose dependent DNA damage in mice. Jul 1998 Lioi study shows that glyphosate induces cell stress in animal cells. Dec 1998 Monsanto s Reaction: Need to hire an expert to refute these studies, so Monsanto reaches out to Dr. James Parry.
63 Dec 1998 Peluso study shows that Roundup exposure induces dose dependent DNA damage in mice. Jul 1998 Lioi study shows that glyphosate induces cell stress in animal cells. Dec 1998 Monsanto s Reaction: Need to hire an expert to refute these studies, so Monsanto reaches out to Dr. James Parry.
64 Dr. James Parry Author of two influential textbooks Comparative Genetic Toxicology and Principles and Methods of Genetic Toxicology Published over 300 papers on toxicology Founder of Journal Mutagenesis and the European Journal of Molecular Genetics and Toxicology President of the European Environmental Mutagen Society
65 Dr. James Parry Monsanto Unsure About Dr. Parry
66 Dr. James Parry Monsanto Unsure About Dr. Parry
67 Dr. James Parry Monsanto Unsure About Dr. Parry
68 Dr. James Parry Monsanto Unsure About Dr. Parry
69 Dec 1998 Peluso study shows that Roundup exposure induces dose dependent DNA damage in mice. Jul 1998 Lioi study shows that glyphosate induces cell stress in animal cells. Dec 1998 Monsanto s Reaction: Need to hire an expert to refute these studies, so Monsanto reaches out to Dr. James Parry.
70 Dec 1998 Peluso study shows that Roundup exposure induces dose dependent DNA damage in mice. Jul 1998 Lioi study shows that glyphosate induces cell stress in animal cells. Dec 1998 Monsanto s Reaction: Need to hire an expert to refute these studies, so Monsanto reaches out to Dr. James Parry.
71 Feb 1999 Dr. Parry submits his first internal report, concluding glyphosate is genotoxic.
72 Feb 1999 Dr. Parry submits his first internal report, concluding glyphosate is genotoxic.
73 Feb 1999 Dr. Parry submits his first internal report, concluding glyphosate is genotoxic.
74 Feb 1999 Dr. Parry submits his first internal report, concluding glyphosate is genotoxic.
75 Feb 1999 Dr. Parry submits his first internal report, concluding glyphosate is genotoxic.
76 Feb 1999 Dr. Parry submits his first internal report, concluding glyphosate is genotoxic.
77 Feb 1999 Dr. Parry submits his first internal report, concluding glyphosate is genotoxic.
78 Feb 1999 Dr. Parry submits his first internal report, concluding glyphosate is genotoxic.
79 Feb 1999 Dr. Parry submits his first internal report, concluding glyphosate is genotoxic. Apr 1999 Monsanto Reaction: Monsanto decides to give Dr. Parry more data with the hope of turning him around.
80 Feb 1999 Dr. Parry submits his first internal report, concluding glyphosate is genotoxic. Apr 1999 Monsanto Reaction: Monsanto decides to give Dr. Parry more data with the hope of turning him around.
81 Feb 1999 Dr. Parry submits his first internal report, concluding glyphosate is genotoxic. Apr 1999 Monsanto Reaction: Monsanto decides to give Dr. Parry more data with the hope of turning him around.
82 Feb 1999 Dr. Parry submits his first internal report, concluding glyphosate is genotoxic. Apr 1999 Monsanto Reaction: Monsanto decides to give Dr. Parry more data with the hope of turning him around.
83 Aug 1999 Dr. Parry submits second comprehensive report.
84 Aug 1999 Dr. Parry submits second comprehensive report. Clastogen: A clastogen is an agent that can induce mutation by disrupting or damaging chromosomes.
85 Aug 1999 Dr. Parry submits second comprehensive report. Dr. Parry concludes glyphosate is clastogenic.
86 Aug 1999 Dr. Parry submits second comprehensive report. Dr. Parry concludes glyphosate is clastogenic.
87 Aug 1999 Dr. Parry submits second comprehensive report. Dr. Parry concludes glyphosate is clastogenic.
88 Aug 1999 Dr. Parry submits second comprehensive report. Dr. Parry concludes glyphosate is clastogenic.
89 Aug 1999 Dr. Parry submits second comprehensive report. Dr. Parry concludes glyphosate is clastogenic.
90 Aug 1999 Dr. Parry submits second comprehensive report. Dr. Parry concludes glyphosate is clastogenic.
91 Aug 1999 Dr. Parry submits second comprehensive report. Dr. Parry concludes glyphosate is clastogenic.
92 Aug 1999 Dr. Parry submits second comprehensive report. Dr. Parry concludes glyphosate is clastogenic.
93 Aug 1999 Dr. Parry submits second comprehensive report. Dr. Parry concludes glyphosate is clastogenic. Sept 1999 Monsanto Reaction: We simply are not going to do the studies Parry suggests.
94 Aug 1999 Dr. Parry submits second comprehensive report. Dr. Parry concludes glyphosate is clastogenic. Sept 1999 Monsanto Reaction: We simply are not going to do the studies Parry suggests.
95 Aug 1999 Dr. Parry submits second comprehensive report. Dr. Parry concludes glyphosate is clastogenic. Sept 1999 Monsanto Reaction: We simply are not going to do the studies Parry suggests.
96 Aug 1999 Dr. Parry submits second comprehensive report. Dr. Parry concludes glyphosate is clastogenic. Sept 1999 Admission No. 26 Monsanto Reaction: We simply are not going to do the studies Parry suggests. Monsanto admits that it has no record of submitting Dr. Parry s Reports to the EPA.
97 Aug 1999 Dr. Parry submits second comprehensive report. Dr. Parry concludes glyphosate is clastogenic. Sept 1999 Monsanto Reaction: We simply are not going to do the studies Parry suggests.
98 Apr 2000 Ghostwriting: Dr. Heydens ghostwrites Williams paper.
99 Apr 2000 Ghostwriting: Dr. Heydens ghostwrites Williams paper. Ghostwriting: When a company writes a favorable publication and pays a prestigious author to put their name on it.
100 Apr 2000 Ghostwriting: Dr. Heydens ghostwrites Williams paper.
101 Apr 2000 Ghostwriting: Dr. Heydens ghostwrites Williams paper.
102 Apr 2000 Ghostwriting: Dr. Heydens ghostwrites Williams paper.
103 Apr 2000 Ghostwriting: Dr. Heydens ghostwrites Williams paper.
104 Apr 2000 Ghostwriting: Dr. Heydens ghostwrites Williams paper. Apr 2010 Ghostwriting: The Williams paper has served us well over the last decade.
105 Apr 2000 Ghostwriting: Dr. Heydens ghostwrites Williams paper. Apr 2000 Ghostwriting: The Wiliams paper has served us well over the last decade.
106 Apr 2000 Ghostwriting: Dr. Heydens ghostwrites Williams paper. Apr 2000 Ghostwriting: The Williams paper has served us well over the last decade.
107 Apr 2000 Ghostwriting: Dr. Heydens ghostwrites Williams paper. Apr 2000 Ghostwriting: The Wiliams paper has served us well over the last decade.
108 Apr 2000 Ghostwriting: Dr. Heydens ghostwrites Williams paper. Apr 2000 Ghostwriting: The Wiliams paper has served us well over the last decade.
109 Apr 2000 Ghostwriting: Dr. Heydens ghostwrites Williams paper. Apr 2000 Ghostwriting: The Wiliams paper has served us well over the last decade.
110 Apr 2000 Ghostwriting: Dr. Heydens ghostwrites Williams paper. Apr 2000 Ghostwriting: The Williams paper has served us well over the last decade.
111 2. Can Roundup cause cancer? 2. Mechanistic Data Recent Data Findings:
112 2. Can Roundup cause cancer? 2. Mechanistic Data Recent Data Findings: Ghisi (2016)
113 2. Can Roundup cause cancer? 2. Mechanistic Data Recent Data Findings: Ghisi (2016)
114 2. Can Roundup cause cancer? 2. Mechanistic Data Recent Data Findings: Ghisi (2016) Meta-analysis: A statistical approach that combines the results of multiple studies into a single summary estimate.
115 2. Can Roundup cause cancer? 2. Mechanistic Data Recent Data Findings: Ghisi (2016)
116 2. Can Roundup cause cancer? 2. Mechanistic Data Recent Data Findings: Ghisi (2016)
117 2. Can Roundup cause cancer? 2. Mechanistic Data Recent Data Findings: Ghisi (2016)
118 2. Can Roundup cause cancer? 2. Mechanistic Data Recent Data Findings: Ghisi (2016)
119 2. Can Roundup cause cancer? Three Pillars of Cancer Science 1. Animal Carcinogenicity Studies 2. Mechanistic Data 3. Epidemiology
120 2. Can Roundup cause cancer? Three Pillars of Cancer Science 1. Animal Carcinogenicity Studies 2. Mechanistic Data 3. Epidemiology
121 2. Can Roundup cause cancer? 3. Epidemiology Epidemiology: The study of the distribution and causes of disease in human populations. Non-Hodgkin Lymphoma-specific
122 2. Can Roundup cause cancer? 3. Epidemiology Non-Hodgkin Lymphoma: A cancer that starts in white blood cells called lymphocytes, which are part of the body s immune system. Two types: B-Cell (most common) T-Cell (less common)
123 2. Can Roundup cause cancer? 3. Epidemiology Confidence Bound: A range of values where there is a specified probability that the true value lies within it.
124 2. Can Roundup cause cancer? 3. Epidemiology
125 2. Can Roundup cause cancer? 3. Epidemiology
126 2. Can Roundup cause cancer? 3. Epidemiology NHL Never / Ever
127 2. Can Roundup cause cancer? 3. Epidemiology NHL Never / Ever
128 2. Can Roundup cause cancer? 3. Epidemiology NHL Never / Ever
129 2. Can Roundup cause cancer? 3. Epidemiology NHL Never / Ever
130 2. Can Roundup cause cancer? 3. Epidemiology NHL Never / Ever
131 2. Can Roundup cause cancer? 3. Epidemiology NHL Never / Ever Agricultural Health Study
132 2. Can Roundup cause cancer? 3. Epidemiology The Agricultural Health Study Large cohort study following pesticide applicators in North Carolina and Iowa Does not show any association for general NHL Does show association for T-cell NHL
133 2. Can Roundup cause cancer? 3. Epidemiology The Agricultural Health Study Deeply flawed study Many pesticides being studied Exposure classification Imputation defects AHS failed to detect other know carcinogens
134 2. Can Roundup cause cancer? 3. Epidemiology NHL Exposure Duration
135 2. Can Roundup cause cancer? 3. Epidemiology NHL Exposure Duration
136 Mar 1999 Epidemiology: Hardell study shows 230% increased risk of NHL for glyphosate formulation.
137 Mar 1999 Epidemiology: Hardell study shows 230% increased risk of NHL for glyphosate formulation. Apr 1999 Monsanto s Reaction: Hardell study raises index of concern.
138 Mar 1999 Epidemiology: Hardell study shows 230% increased risk of NHL for glyphosate formulation. Apr 1999 Monsanto s Reaction: Hardell study raises index of concern.
139 Mar 1999 Epidemiology: Hardell study shows 230% increased risk of NHL for glyphosate formulation. Apr 1999 Monsanto s Reaction: Hardell study raises index of concern.
140 Mar 1999 Epidemiology: Hardell study shows 230% increased risk of NHL for glyphosate formulation. Apr 1999 Monsanto s Reaction: Hardell study raises index of concern.
141 Mar 1999 Epidemiology: Hardell study shows 230% increased risk of NHL for glyphosate formulation. Aug 2001 Monsanto: Dr. Acquavella learns that Dr. Helen McDuffie plans to publish article showing NHL risk with glyphosate. Apr 1999 Monsanto s Reaction: Hardell study raises index of concern.
142 Mar 1999 Epidemiology: Hardell study shows 230% increased risk of NHL for glyphosate formulation. Aug 2001 Monsanto: Dr. Acquavella learns that Dr. Helen McDuffie plans to publish article showing NHL risk with glyphosate. Apr 1999 Monsanto s Reaction: Hardell study raises index of concern.
143 Mar 1999 Epidemiology: Hardell study shows 230% increased risk of NHL for glyphosate formulation. Aug 2001 Monsanto: Dr. Acquavella learns that Dr. Helen McDuffie plans to publish article showing NHL risk with glyphosate. Apr 1999 Monsanto s Reaction: Hardell study raises index of concern.
144 Mar 1999 Epidemiology: Hardell study shows 230% increased risk of NHL for glyphosate formulation. Aug 2001 Monsanto: Dr. Acquavella learns that Dr. Helen McDuffie plans to publish article showing NHL risk with glyphosate. Apr 1999 Monsanto s Reaction: Hardell study raises index of concern.
145 Nov 2001 Epidemiology: McDuffie study shows 212% increased risk of NHL when using Roundup more than 2 days a year.
146 Nov 2001 Epidemiology: McDuffie study shows 212% increased risk of NHL when using Roundup more than 2 days a year. Nov 2001 Monsanto s Reaction: Celebrate the fact that glyphosate is not mentioned in the abstract.
147 Nov 2001 Epidemiology: McDuffie study shows 212% increased risk of NHL when using Roundup more than 2 days a year. Nov 2001 Monsanto s Reaction: Celebrate the fact that glyphosate is not mentioned in the abstract.
148 Nov 2001 Epidemiology: McDuffie study shows 212% increased risk of NHL when using Roundup more than 2 days a year. Nov 2001 Monsanto s Reaction: Celebrate the fact that glyphosate is not mentioned in the abstract.
149 Nov 2001 Epidemiology: McDuffie study shows 212% increased risk of NHL when using Roundup more than 2 days a year. Nov 2001 Monsanto s Reaction: Celebrate the fact that glyphosate is not mentioned in the abstract.
150 Nov 2001 Epidemiology: McDuffie study shows 212% increased risk of NHL when using Roundup more than 2 days a year. May 2002 Epidemiology: Another Hardell study shows 306% increased risk of NHL for Roundup. Nov 2001 Monsanto s Reaction: Celebrate the fact that glyphosate is not mentioned in the abstract.
151 Nov 2001 Epidemiology: McDuffie study shows 212% increased risk of NHL when using Roundup more than 2 days a year. May 2002 Epidemiology: Another Hardell study shows 306% increased risk of NHL for Roundup. Nov 2001 Monsanto s Reaction: Celebrate the fact that glyphosate is not mentioned in the abstract. Mar 2003 Epidemiology: shows 210% increased risk of NHL for glyphosate formulation. Controlled for 60 other pesticides.
152 Nov 2001 Epidemiology: McDuffie study shows 212% increased risk of NHL when using Roundup more than 2 days a year. May 2002 Epidemiology: Another Hardell study shows 306% increased risk of NHL for Roundup. Nov 2001 Monsanto s Reaction: Celebrate the fact that glyphosate is not mentioned in the abstract. Mar 2003 Epidemiology: shows 210% increased risk of NHL for glyphosate formulation. Controlled for 60 other pesticides.
153 Nov 2001 Epidemiology: McDuffie study shows 212% increased risk of NHL when using Roundup more than 2 days a year. May 2002 Epidemiology: Another Hardell study shows 306% increased risk of NHL for Roundup. Nov 2001 Monsanto s Reaction: Celebrate the fact that glyphosate is not mentioned in the abstract. Mar 2003 Epidemiology: shows 210% increased risk of NHL for glyphosate formulation. Controlled for 60 other pesticides.
154 Nov 2001 Epidemiology: McDuffie study shows 212% increased risk of NHL when using Roundup more than 2 days a year. May 2002 Epidemiology: Another Hardell study shows 306% increased risk of NHL for Roundup. Nov 2001 Monsanto s Reaction: Celebrate the fact that glyphosate is not mentioned in the abstract. Mar 2003 Epidemiology: shows 210% increased risk of NHL for glyphosate formulation. Controlled for 60 other pesticides.
155 Sept 2003 Monsanto s Reaction: Dr. Acquavella warns that the De Roos study could add fuel to the fire.
156 Sept 2003 Monsanto s Reaction: Dr. Acquavella warns that the De Roos study could add fuel to the fire.
157 Sept 2003 Monsanto s Reaction: Dr. Acquavella warns that the De Roos study could add fuel to the fire.
158 Sept 2003 Monsanto s Reaction: Dr. Acquavella warns that the De Roos study could add fuel to the fire. Jan 2005 Epidemiology: De Roos publishes first iteration of the AHS, showing no association between Roundup and NHL.
159 Sept 2003 Monsanto s Reaction: Dr. Acquavella warns that the De Roos study could add fuel to the fire. Jan 2005 Epidemiology: De Roos publishes first iteration of the AHS, showing no association between Roundup and NHL.
160 Jul 2008 Epidemiology: Eriksson study shows 202% increased risk of NHL for Roundup. Also shows 236% increased risk of NHL when used for more than 10 days a year.
161 Jul 2008 Epidemiology: Eriksson study shows 202% increased risk of NHL for Roundup. Also shows 236% increased risk of NHL when used for more than 10 days a year. Oct 2008 Monsanto s Reaction: How do we combat this?
162 Jul 2008 Epidemiology: Eriksson study shows 202% increased risk of NHL for Roundup. Also shows 236% increased risk of NHL when used for more than 10 days a year. Oct 2008 Monsanto s Reaction: How do we combat this?
163 Jul 2008 Epidemiology: Eriksson study shows 202% increased risk of NHL for Roundup. Also shows 236% increased risk of NHL when used for more than 10 days a year. Oct 2008 Monsanto s Reaction: How do we combat this?
164 Jul 2008 Epidemiology: Eriksson study shows 202% increased risk of NHL for Roundup. Also shows 236% increased risk of NHL when used for more than 10 days a year. Apr 2014 Epidemiology: Schinasi & Leon meta analysis reveals Roundup increases overall NHL risk by 150%. Oct 2008 Monsanto s Reaction: How do we combat this?
165 Jul 2008 Epidemiology: Eriksson study shows 202% increased risk of NHL for Roundup. Also shows 236% increased risk of NHL when used for more than 10 days a year. Apr 2014 Epidemiology: Schinasi & Leon meta analysis reveals Roundup increases overall NHL risk by 150%. Oct 2008 Monsanto s Reaction: How do we combat this?
166 Oct 2016 Epidemiology: Monsanto-sponsored metaanalysis shows a 130% increased risk of NHL from Roundup use.
167 Oct 2016 Epidemiology: Monsanto-sponsored metaanalysis shows a 130% increased risk of NHL from Roundup use. Nov 2017 Epidemiology: Latest version of the AHS is published using unreliable imputed data. Shows no overall NHL risk.
168 Oct 2016 Epidemiology: Monsanto-sponsored metaanalysis shows a 130% increased risk of NHL from Roundup use. Nov 2017 Epidemiology: Latest version of the AHS is published using unreliable imputed data. Shows no overall NHL risk.
169 Oct 2016 Epidemiology: Monsanto-sponsored metaanalysis shows a 130% increased risk of NHL from Roundup use. Nov 2017 Epidemiology: Latest version of the AHS is published using unreliable imputed data. Shows no overall NHL risk. 425%
170 Oct 2016 Epidemiology: Monsanto-sponsored metaanalysis shows a 130% increased risk of NHL from Roundup use. Nov 2017 Epidemiology: Latest version of the AHS is published using unreliable imputed data. Shows no overall NHL risk.
171 2. Can Roundup cause cancer? Three Pillars of Cancer Science 1. Animal Carcinogenicity Studies 2. Mechanistic Data 3. Epidemiology
172 2. Can Roundup cause cancer?
173 2. Can Roundup cause cancer?
174 14 Mar 2014 Epidemiology: Schinasi & Leon conduct epidemiological meta analysis. Oct 2014 Monsanto: Learns that IARC will be reviewing glyphosate, and Dr. Heydens admits Monsanto is vulnerable. Glyphosate increases overall NHL risk by 150% and B cell lymphoma by 200%.
175 14 Mar 2014 Epidemiology: Schinasi & Leon conduct epidemiological meta analysis. Oct 2014 Monsanto: Learns that IARC will be reviewing glyphosate, and Dr. Heydens admits Monsanto is vulnerable. Glyphosate increases overall NHL risk by 150% and B cell lymphoma by 200%.
176 2. Can Roundup cause cancer? Leading world experts on cancer 17 scientists from the EPA, California EPA, and worldwide Over six months reviewing all peer-reviewed science on glyphosate Held a week-long meeting Unanimous vote
177 2. Can Roundup cause cancer? Participants Members: Aaron Blair, National Cancer Institute, USA (Overall Chair) Charles W. Jameson, CWJ Consulting, LLA, USA Matthew T. Martin, U.S. Environmental Protection Agency, USA Lauren Zeise, California Environmental Protection Agency, USA Matthew K. Ross, Mississippi State University, USA Invited Specialists Christopher J. Portier, Agency for Toxic Substances and Disease Registry, USA Representatives of National and International Health Agencies Jesudoss Rowland, U.S. Environmental Protection Agency, USA Observers Thomas Sorahan, for Monsanto Company, USA Patrice Sutton, for the University of California, San Francisco, Program on Reproductive Health and the Environment
178 2. Can Roundup cause cancer? Three Pillars of Cancer Science 1. Animal Carcinogenicity Studies 2. Mechanistic Data 3. Epidemiology Sufficient
179 2. Can Roundup cause cancer? Three Pillars of Cancer Science 1. Animal Carcinogenicity Studies 2. Mechanistic Data 3. Epidemiology Sufficient
180 2. Can Roundup cause cancer? Three Pillars of Cancer Science 1. Animal Carcinogenicity Studies 2. Mechanistic Data 3. Epidemiology Sufficient Strong
181 2. Can Roundup cause cancer? Three Pillars of Cancer Science 1. Animal Carcinogenicity Studies 2. Mechanistic Data 3. Epidemiology Sufficient Strong Limited
182 2. Can Roundup cause cancer? March 2015: IARC unanimously decides to list glyphosate as a class 2A carcinogen a probable human carcinogen.
183 2. Can Roundup cause cancer? Monsanto s Response to IARC
184 Part I 2. Current state of science Monsanto s Response to IARC February 23, 2015
185 2. Can Roundup cause cancer? Monsanto s Response to IARC
186 2. Can Roundup cause cancer? Nearly 100 scientists from all over the world endorse IARC s assessment of glyphosate
187 2. Can Roundup cause cancer? Nearly 100 scientists from all over the world endorse IARC s assessment of glyphosate
188 2. Can Roundup cause cancer? Nearly 100 scientists from all over the world endorse IARC s assessment of glyphosate
189 2. Can Roundup cause cancer? Nearly 100 scientists from all over the world endorse IARC s assessment of glyphosate
190 2. Can Roundup cause cancer?
191 2. Can Roundup cause cancer? Glyphosate v. Roundup No one tests Roundup
192 2. Can Roundup cause cancer? Charles Benbrook, PhD. B.A. in Economics from Harvard University (1971) and Ph.D. in Agricultural Economics from the University of Wisconsin (1980). Former Staff Director of the Subcommittee on Department Operations, Research, and Foreign Agriculture ( DOFRA ) of the House Committee on Agriculture. Organized several DOFRA hearings on pesticide issues, and worked with Members of Congress in drafting potential changes in federal laws impacting the Environmental Protection Agency s ( EPA ) Office of Pesticide Programs ( OPP ).
193 2. Can Roundup cause cancer? 1. The EPA does not test anything. 2. Vulnerable to political shifts. 3. EPA s Scientific Advisory Panel split. 4. EPA s Office of Research and Development disagrees.
194 Opening Statement Roadmap: 1. What is Roundup? 2. Can Roundup cause cancer? Yes. 3. Did Roundup cause Mr. Johnson s cancer? 4. What are Mr. Johnson s damages? 5. Should Monsanto be punished for its conduct?
195 Opening Statement Roadmap: 1. What is Roundup? 2. Can Roundup cause cancer? Yes. 3. Did Roundup cause Mr. Johnson s cancer? 4. What are Mr. Johnson s damages? 5. Should Monsanto be punished for its conduct?
196 3. Did Roundup cause Mr. Johnson s cancer? Chadi Nabhan, M.D. Board-Certified hematologist and medical oncologist specializing in Non-Hodgkin Lymphoma ( NHL ). Vice President and Chief Medical Officer of Cardinal Health Specialty Solutions. Former Medical Director of the Clinical Cancer Center at the University of Chicago. Treated thousands of lymphoma patients.
197 3. Did Roundup cause Mr. Johnson s cancer? William Sawyer, PhD. Ph.D. in toxicology from Indiana University School of Medicine (1983). Diplomate of the American Board of Forensic Medicine with more than 28 years of experience in public health and forensic toxicology, including five years of governmental service. Former Assistant Professor (23 years) at the Department of Medicine, Upstate Medical University, Syracuse, New York. 14 years of experience as a licensed clinical and environmental laboratory director.
198 3. Did Roundup cause Mr. Johnson s cancer? 2012 New Job at Benicia School District
199 3. Did Roundup cause Mr. Johnson s cancer? Pest Management
200 3. Did Roundup cause Mr. Johnson s cancer? The Label:
201 3. Did Roundup cause Mr. Johnson s cancer? The Label:
202 3. Did Roundup cause Mr. Johnson s cancer? The Label:
203 3. Did Roundup cause Mr. Johnson s cancer? Admission No. 13 Monsanto admits that it has never warned any consumer that Roundup could cause cancer Admission No. 14 Monsanto admits that it has never warned Mr. Johnson that Roundup could cause cancer.
204 3. Did Roundup cause Mr. Johnson s cancer? Personal Protection
205 3. Did Roundup cause Mr. Johnson s cancer? Multiple Heavy Exposures Nov. 2014: Reports to Monsanto
206 Mr. Johnson s Cancer: Multiple Heavy Exposures Nov. 2014: Reports to Monsanto
207 3. Did Roundup cause Mr. Johnson s cancer? Multiple Heavy Exposures Nov. 2014: Reports to Monsanto
208 3. Did Roundup cause Mr. Johnson s cancer? Multiple Heavy Exposures Mar. 2015: Reports Problem Again
209 3. Did Roundup cause Mr. Johnson s cancer? Multiple Heavy Exposures 2015: Reports Problem Again
210 Mr. 3. Did Johnson s Roundup cause Cancer: Mr. Johnson s cancer? Multiple Heavy Exposures 2015: Reports Problem Again
211 Mr. 3. Did Johnson s Roundup cause Cancer: Mr. Johnson s cancer? Multiple Heavy Exposures 2015: Reports Problem Again
212 3. Did Roundup cause Mr. Johnson s cancer? Multiple Heavy Exposures 2015: Reports Problem Again
213 3. Did Roundup cause Mr. Johnson s cancer? While Mr. Johnson was waiting for a response from Monsanto, he continued to use Roundup and Ranger Pro for another spraying season. His cancer got worse and worse. Why? Roundup can promote cancer.
214 3. Did Roundup cause Mr. Johnson s cancer?
215 3. Did Roundup cause Mr. Johnson s cancer?
216 3. Did Roundup cause Mr. Johnson s cancer?
217 3. Did Roundup cause Mr. Johnson s cancer? Issues to Consider 1. Exposure 2. Latency 3. Other possible causes 4. Warning
218 Opening Statement Roadmap: 1. What is Roundup? 2. Can Roundup cause cancer? Yes. 3. Did Roundup cause Mr. Johnson s cancer? 4. What are Mr. Johnson s damages? 5. Should Monsanto be punished for its conduct? Yes.
219 Opening Statement Roadmap: 1. What is Roundup? 2. Can Roundup cause cancer? Yes. 3. Did Roundup cause Mr. Johnson s cancer? 4. What are Mr. Johnson s damages? 5. Should Monsanto be punished for its conduct? Yes.
220 4. What are Mr. Johnson s damages? Compensatory Damages Economic damages Non-economic damages physical pain
221 4. What are Mr. Johnson s damages? Compensatory Damages Economic damages Non-economic damages physical pain mental suffering loss of enjoyment of life
222 4. What are Mr. Johnson s damages? Compensatory Damages Economic damages Non-economic damages physical pain mental suffering loss of enjoyment of life disfigurement physical impairment
223 4. What are Mr. Johnson s damages? Compensatory Damages Economic damages Non-economic damages physical pain mental suffering loss of enjoyment of life disfigurement physical impairment grief anxiety humiliation emotional distress
224 4. What are Mr. Johnson s damages? Compensatory Damages Economic damages Non-economic damages physical pain mental suffering loss of enjoyment of life disfigurement physical impairment grief anxiety humiliation emotional distress
225 Opening Statement Roadmap: 1. What is Roundup? 2. Can Roundup cause cancer? Yes. 3. Did Roundup cause Mr. Johnson s cancer? 4. What are Mr. Johnson s damages? 5. Should Monsanto be punished for its conduct? Yes.
226 Opening Statement Roadmap: 1. What is Roundup? 2. Can Roundup cause cancer? Yes. 3. Did Roundup cause Mr. Johnson s cancer? 4. What are Mr. Johnson s damages? 5. Should Monsanto be punished for its conduct? Yes.
227 5. Should Monsanto be punished for its conduct? Net Worth: $6.6 Billion
228 5. Should Monsanto be punished for its conduct?
229 5. Should Monsanto be punished for its conduct? 1. Why did no one from Monsanto call Mr. Johnson back, even after IARC? 2. Why did Monsanto not send the Perry reports to the EPA and, instead, ghostwrite the Williams paper? 3. Why did Monsanto refuse to study the Roundup formulation, like Dr. Parry suggested 20 years ago? 4. Why did Monsanto feel the need to combat published articles raising concerns about the safety of Roundup?
230 5. Should Monsanto be punished for its conduct? Dr. Kirk Azevedo Sales Representative (former)
231 5. Should Monsanto be punished for its conduct? Dr. Kirk Azevedo Sales Representative (former)
232 5. Should Monsanto be punished for its conduct? We re about making money, so get it straight.
233 Opening Statement Roadmap: 1. What is Roundup? 2. Can Roundup cause cancer? Yes. 3. Did Roundup cause Mr. Johnson s cancer? 4. What are Mr. Johnson s damages? 5. Should Monsanto be punished for its conduct? Yes. Yes.
234
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