RESEARCH ARTICLE. Systematic Review of Research into the Psychological Aspects of Prostate Cancer in Asia: What do we Know?
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1 DOI:htt://dx.doi.org/ /APJCP Psychosocial Asects of Prostate Cancer in Asia - Systematic Review RESEARCH ARTICLE Systematic Review of Research into the Psychological Asects of Prostate Cancer in Asia: What do we Know? Suzanne Kathleen Chambers 1,2,3,4,5, Melissa Karen Hyde 1, David Fu-Keung I 6, Jeffrey Charles Dunn 1,3,7, Robert Alexander Gardiner 5,7,8 Abstract Background: To review the eer reviewed literature on the sychological asects of the rostate cancer exerience of men in Asia. Materials and Methods: Medline and PsycINFO, CINAHL, ProQuest, and Web of Science (1999 November Week 4, 2012) were searched. Inclusion criteria were: included men with rostate cancer and/or their artners or caregivers who identify as Asian recruited in an Asian country; and assessed health-related quality of life, sychological and social adjustment relating to rostate cancer and ublished in English after 1 st January 1999 and rior to 30 th November, Study aims; design; quality; level of evidence, and key results were assessed. Results: 43 articles met all inclusion criteria and were retained for initial review. Of these most focussed on health-related QOL with only five evidence Level IV studies from Jaan and Taiwan including a secific sychological focus. Of these, one was a cross-sectional case control study; three were crosssectional descritive quantitative designs; one was a cross-sectional descritive qualitative study. From the data available, a substantive sub grou of men with rostate cancer (aroximately one third) in these countries exerience clinically high sychological distress and decision regret. Conclusions: Research on the sychological needs of men with the increasingly revalent condition of rostate cancer in Asian countries is scant with only a small number of low level evidence descritive studies identified. Future research to underin the develoment and evaluation of effective and culturally relevant sychological and suortive care interventions for such men is urgently needed. Keywords: Prostate cancer - systematic review - sychological adjustment - quality of life - Asia Asian Pacific J Cancer Prev, 14 (4), Introduction In Western countries, rostate cancer is highly revalent such that in Australia, the United States, and the United Kingdom it is now the most common internal male cancer (Baade et al., 2009). This high incidence and revalence has been attributed to the increasing utake of PSA testing and a western lifestyle (Baade et al., 2009). The diagnosis of cancer brings with it a sychological burden consistent with a major life stress, and this is the case for rostate cancer as for other cancers (Zabora et al., 2001). Accordingly, sycho-oncology researchers in countries with a high rostate cancer revalence have over the ast decade focussed their efforts in develoing a clear understanding of the sychological imact of rostate cancer on men and their artners and finding effective ways to imrove sychological outcomes for those affected (Chambers et al., 2011). Research to date suggests that a substantial subgrou of men with rostate cancer exerience ongoing clinically significant sychological distress after rostate cancer, although study limitations include small and non-reresentative samles; inconsistency in measurement; and few longitudinal studies (Bloch et al., 2007). More recent research has demonstrated that men s sychological resonses to rostate cancer are highly heterogeneous, with younger men (esecially those with lower incomes and less education) most at risk of oorer outcomes (Chambers et al., 2012a); with sychological factors such as masculine self-esteem (Chambers et al., 2012b) and coing aroaches (Roesch et al., 2005) also imortant. An issue however that has yet to be considered is the extent to which researchers have considered the sychosocial imlications of a rostate cancer diagnosis for men in non-western countries. Secifically, as PSA testing increases in non-western countries, lifestyle becomes more influenced by Western trends in diet and hysical activity, and life exectancy 1 Griffith Health Institute, Griffith University, 2 Prostate Cancer Foundation of Australia, 3 Cancer Research Centre, Cancer Council Queensland, 4 Health and Wellness Institute, Edith Cowan University, 5 Centre for Clinical Research, 7 School of Social Science, University of Queensland, 8 Deartment of Urology, Royal Brisbane and Women s Hosital, Brisbane, Australia, 6 Faculty of Health and Social Sciences, Hong Kong Polytechnic University, Hong Kong *For corresondence: suzanne.chambers@griffith.edu.au Asian Pacific Journal of Cancer Prevention, Vol 14,
2 Suzanne K Chambers et al increases, the incidence of rostate cancer in the Asia-Pacific is also increasing (Baade et al., 2012). As examles, in South Korea between 1999 and 2009 rostate cancer incidence rose by 13% er year (the largest increase in the Asia-Pacific) followed closely by Shanghai with an annual increase of 12% between 1988 and In all, 14% of rostate cancer diagnoses worldwide occur in the Asia Pacific, most often in Jaan (32%) and China (28%). On the basis that rostate cancer is now emerging as a cancer control riority area for Asia in the future, the need to understand the imact of rostate cancer on the lives of men and their artners from non-western cultures will become critical for health services lanning. Accordingly, we undertook a review of the sychological asects of the rostate cancer exerience of men in Asia to describe the level of research activity in this area and key areas of focus and from this rovide recommendations for future research. Materials and Methods Medline and PsycINFO, CINAHL, ProQuest, and Web of Science (1999 November Week 4, 2012) were searched and articles related to rostate cancer were extracted. Cited reference and hand searches of retrieved article references lists were also conducted. The following keywords and subject headings were used: Cancer.m, neolasm$.m, metastasis.m, malign$.m, rostat$.m, sychosocial.m, well-being.m, coing.m, anxiety. m, deression.m, HRQoL.m, survivor.m, ain.m, fatigue.m, Asia$.m. China.m, Chinese.m, Hong Kong.m, India$.m, Indonesia$.m, Jaan$.m, Korea$. m, Philliines.m, Filiino.m, Taiwan$.m, Thai$. m. To enhance the literature search, these terms were used in conjunction with searches aimed at identifying a comrehensive breadth of cancer-based research related to sychological adjustment. For instance, ex quality of life/, ex social adjustment and ex sychological adjustment/ were also searched. Potentially relevant articles were identified by examining the title and abstract and then retrieved for more detailed evaluation against the inclusion criteria by two reviewers. Both qualitative and quantitative studies were included. Editorials, books, dissertations, case reorts, commentaries, systematic reviews, reviews, and meta-analyses were excluded. Studies were included if they met the following redetermined inclusion criteria: Were ublished in English and included men with rostate cancer and/or their artners or caregivers who identify as Asian (either at least 80% of articiants are Asian and had/have rostate cancer or were artners or caregivers of rostate cancer atients or there was an Asian secific sub-grou analysis) and were recruited in an Asian context; and Described quality of life, health-related quality of life, or sychological and social adjustment of rostate cancer atients who identify as Asian; OR Comared quality of life, health-related quality of life, or sychological adjustment of rostate cancer atients who identify as Asian against healthy controls who identify as Asian or against non-asian rostate cancer oulations OR Assessed health-related quality of life, sychological and social adjustment 2622 Asian Pacific Journal of Cancer Prevention, Vol 14, 2013 relating to rostate cancer and included an outcome of interest hysical health, mental health, health utility, cancer secific distress; deression/anxiety severity, disability, mobility, hysical activity, social activity, and health status. Research articles that focussed rincially on domain-secific quality of life (i.e., urinary, bowel, sexual roblems) in relation to evaluating treatment effects and that did not include a secific sychological comonent were excluded. Studies that focussed on health-related quality of life were noted but did not undergo quality assessment or full review. The methodological quality of the included sychological studies was assessed indeendently by two reviewers (SC, MH) and differences resolved by consensus with searate criteria for qualitative and quantitative studies. The assessment of the quality of qualitative studies was based on criteria held in the literature to denote high quality (Elliott et al., 1999; Daly et al., 2007; Chwalisz et al., 2008). Criteria included whether: the samling frame was described, justified, or met; the framework for the study design, methodology and orientation disclosed; interviewer bias was addressed; the method of analysis was described; reliability and validity checks were included; data were clearly resented. To assess the quality of the design of included quantitative cross-sectional studies, criteria from established tools for cohort and case-control studies (NHMRC, 2000) were adated focussing on reresentativeness of the study samle (articiant selection), measures alied (reliability and validity), attrition bias (articiation rates) and evidence of follow u. Results Search results The rocess of identifying relevant articles for the review is outlined in Figure 1. The combined Medline and PsycINFO, CINAHL, ProQuest, and Web of Science database searches and cited reference searches identified 122 citations. On examination of titles and abstracts, 43 articles that met all inclusion criteria and included Asian articiants recruited in an Asian context were retained for Articles identified by OvidSP Medline & PsycINFO, CINAHL, ProQuest, Web of Science, and cited reference searches (N=122) Articles excluded after examining titles and abstracts (n=79) - Reviews, systematic reviews, or meta-analyses (n=3) - No Psychological Adj, Social Adj, QOL, or HRQOL (n=11) - Surgery/Treatment only focus (n=11) - Pharmacologic/Drug Theray only focus (n=26) -Domain-secific QOL only focus (n=28) Articles otentially relevant and retrieved for evaluation (n=43) Included Psychosocial articles (n=5) - Cross sectional case control (n=1) - Cross sectional descritive quantitative (n=3) - Cross sectional descritive qualitative (n=1) HR Quality of life articles (n=38) - Cross sectional descritive quantitative (n=7) - Prosective descritive quantitative (n=19) - Comarison of side effects of medical treatments (n=12) Figure 1. Final Process of Inclusion and Exclusion of Studies for the Literature Review
3 DOI:htt://dx.doi.org/ /APJCP Psychosocial Asects of Prostate Cancer in Asia - Systematic Review Table 1. Summary of Psychosocial Articles on Prostate Cancer in Asia Key Results Study Patients Aim Variables and corresonding measures Planned outcomes Family history of rostate cancer, PSA, atient rediction of cancer diagnosis, and Tye 1 ersonality (marginally =.018) significantly different between case and control grous. After controlling for atient rediction of cancer diagnosis and PSA, the variables Tye 1 ersonality (OR: 4.2, 95% CI ) and family history of rostate cancer (resence) (OR: 10.8, 95% CI ) redicted rostate cancer diagnosis in multile logistic regression analysis, 66.5% correctly classified, Wald χ2 =22.6 (df = 4, =.0002). Prostate cancer diagnosis History sheet including demograhics, PSA level, atient rediction of cancer diagnosis (0-100 Visual Analogue Scale), and family history of rostate cancer within 3rd degree relatives. Food consumtion (Food Frequency Questionnaire FFQ) Harmony seeking Tye 1 ersonality (The Jaanese version of the Short Interersonal Reactions Inventory SIRI33) General ersonality (NEO-FFI) Coing style (The Coing Inventory for Stressful Situations - CISS) Psychological stress resonse (Profile of Mood States POMS) Investigate whether harmony-seeking ersonality is related to the occurrence of rostate cancer N = 167 men admitted for biosy of the rostate gland to confirm the diagnosis of rostate cancer between Aril 2001 and March were subsequently allocated to the case grou (resence of rostate cancer) and 81 to the control grou (absence of rostate cancer) Case mean age: 65.8 yrs Control mean age: 64.1 yrs Kumano 2005 (Jaan) Followed u on average 32 months (RP) and 29 months (ERBT) ost-treatment. No statistically significant differences in sychological distress based on tye of treatment or sexual bother or sexual function. Younger (70 yrs or below) had higher deression scores than older (over 70 yrs) men. Cases (scoring 11 on HADS-T = sychological distress) as comared to non-cases had lower HRQOL overall, and men with higher sychological distress had greater urinary and bowel bother and dysfunction and IPSS scores, than non-cases. Logistic regression showed that greater ost-treatment sychological distress was redicted by greater urinary bother (OR: 3.039, 95% CI: ) and bowel dysfunction (OR: 2.343, 95% CI: ) and higher IPSS (OR: 3.29, 95% CI: ) after controlling for tye of treatment, age, comorbidities, PSA, time since treatment and adjuvant theray. Psychological distress (anxiety and deression) General HRQOL emotional and social functions (SF-36) Urinary, bowel and sexual function and bother (UCLA Prostate Cancer Index) Voiding symtoms (International Prostate Symtom Score IPSS) Deression and anxiety (Hosital Anxiety and Deression Scale HADS). HADS-Total Score 0-10 categorised as non-cases, and scores 11 were categorised as cases. Examine the association between sychological distress (anxiety and deression) and health-related quality of life. 340 men with localized rostate cancer treated with radical rostatectomy (n = 253) or external beam radiation theray (n = 87). RP atients mean age: 68.9 yrs ERBT atients mean age: 75.7 yrs Namiki 2007 (Jaan) 31% regretted undergoing radical rostatectomy. To two reasons for regret were sexual dysfunction (33%) and urinary incontinence (9%). Stewise multile regression showed that significant redictors of treatment decision regret were not choosing to have an RP again, a lack of understanding of the treatment and comlications, sexual bother, younger age, and bowel bother. Treatment decision regret Demograhics including age, marital status, education level, emloyment status. Disease-related variables including tye of radical rostatectomy, number of months after RP, and satisfaction with treatment (lower scores = less satisfied). Disease-secific HRQOL urinary, bowel and sexual function and bother (UCLA Prostate Cancer Index) Treatment decision regret (modified Clark regret scale, 4-items, 5-oint Likert scale scored 0 none of the time to 5 all of the time ). Understand the treatment decision regret exerienced by atients after a radical rostatectomy and the factors associated with regret 100 men diagnosed with rostate cancer who underwent radical rostatectomy between 2004 and 2010 Mean age: yrs Lin 2011 (Taiwan) Significant difference in understanding cancer treatment and comlications between suort grou (82.1% understood) and non-suort grou (17.9% understood). Lin 2012 (Taiwan) Particiant s uncertainty was lower in the sychological suort grou comared to the non-suort grou, F = , <.001. Perceived uncertainty about illness Perceived uncertainty about illness (Chinese version of the Mishel Uncertainty Illness Scale MUIS) Background data sheet including age, marital status, education level, emloyment status, number of months since the RP rocedure, occurrence of urinary incontinence, level of understanding of rostate cancer treatment and comlications. Psychological suort was delivered by a researcher in the hosital redischarge, a research assistant by hone, and in-clinic visits after RP (twice during the first month and once after the first month). Psychological suort content included: (i) 1hr of education about rostate anatomy, the RP rocedure, and associated comlications; (ii) strategies to overcome comlications; (iii) listening to atient s life exeriences after RP; and (iv) questions and answers. To comare levels of uncertainty for men who received sychological suort comared to those who did not after radical rostatectomy 105 men who underwent radical rostatectomy were recruited aroximately 1 month osttreatment and articiated in the study aroximately 3 months after treatment. Particiants were initially selected for either the suort grou (n = 62 recruited between December 2007 and Aril 2010; received sychological suort in addition to normal care and follow u) or the non-suort grou (n = 43 recruited between August 2002 and November 2007; received normal care and follow u only). Mean age suort grou: yrs. Mean age non-suort grou: yrs n/a Particiants who reorted receiving information about life rognosis unexectedly were shocked by their rognosis, regardless of terminal or early stage. Others sought rognostic information elsewhere (e.g. websites). Others who asked for life rognosis disclosure felt it heled reare them for end of life Others feared that hearing rognostic information would become a self-fulfilling rohecy. Authors concluded that rognostic information should include not only survival estimates but also treatment imlications and meaningful use of time, and that this information should be used to emower atients in their decision-making. Extracted information from unstructured and structured arts of the interview related to rognostic disclosure including information received from medical rofessionals, the imact of cancer on life lans, and fears or worries about the future. Exlored the toic of disclosure of life rognosis Narrative interviews were conducted between December 2007 and March 2009 with 42 women with breast cancer and 49 men with rostate cancer (various stages). Men age distribution: (50-59 yrs n = 5; yrs n = 18; yrs n = 21; 80 yrs n = 5) Sato 2012 (Jaan) Asian Pacific Journal of Cancer Prevention, Vol 14,
4 Suzanne K Chambers et al Figure 2. Trend in Number of Asian Psychosocial and HRQOL Prostate Cancer Articles from (n=43) review. Of these articles 38 were from Jaan; three from China and two from Korea. Figure 2 shows the trend in number of articles over time. Research in this area began to emerge in 2003 with a clear increase in 2009 that has since declined. In the final search ste and in line with the focus of this review on identifying sychological research with men with rostate cancer in Asia, research articles that included a general or health-related quality of life (HR- QOL) asect but did not include a clearly defined focus on sychological outcomes were excluded (n=38; 7 crosssectional descritive quantitative studies; 19 rosective descritive quantitative studies; and 12 medical treatment intervention efficacy) leaving 5 sychosocial articles. The excluded HR-QOL articles redominantly described the interaction between domain secific such as urinary and bowel symtoms and HR-QOL, rather than sychological morbidity er se. However, those studies that did reort and discuss the mental wellbeing comonent of QOL (n=13; assessing Jaanese atients) tended to reort imroved function over time for men with localised or low risk rostate cancer (Namiki et al., 2005; 2009; Sugimoto et al., 2008; Wakatsuki et al., 2008) with more interrution to wellbeing when men were receiving androgen derivation theray (Namiki et al., 2005; Wakatsuki et al., 2008) or had biochemical recurrence (Namiki et al., 2007). substantive subgrous with high sychological distress with 15% of atients reaching caseness for anxiety and 46% reaching caseness for deression. Men who reached caseness for overall sychological distress (34%) had oorer HR-QOL comared to those who were not distressed. Lin (2012) in a cross sectional study in Taiwan assessed illness uncertainty in two cohorts: one in which the men had received a radical rostatectomy (n=62) and received treatment education and emathic listening from the researcher and a second in which the men did not receive this suort (n=43). Men who had received suort had lower uncertainty however, as the study only included one ost-test assessment, it is not ossible to draw firm conclusions from these results. The same author assessed treatment regret in 100 Taiwanese men who had undergone radical rostatectomy and found 31% to reort regret about their treatment decision with bothersome adverse sexual and bowel side effects, with not understanding the treatment and its comlications redicting greater regret (Lin, 2011). Finally, Sato et al. (2012) undertook a qualitative narrative analysis of 42 Jaanese breast and 49 rostate cancer atient exeriences of being told their cancer rognosis and their references for how this should be done. While some men sought rognostic information and saw this as a means of maintaining control over their lives, others found this information shocking. A reason given for not wanting rognostic information was to maintain hoe; and there was evidence of eole not understanding this information when it was given. Study quality was good: a convenience samle was used and a samle size rationale was rovided, as were a clear qualitative framework and data analysis with objective measurement and resentation. However, checks for data credibility were not well described. Discussion Study characteristics and outcomes of included sychological studies Of the five sychological articles retained, one was a cross-sectional case control study; three were crosssectional descritive quantitative studies; one was a cross-sectional descritive qualitative study (Table 1). All were Level IV evidence (Olver et al., 2012). For the quantitative studies articiation rates were accetable to very good (78-91%); validated and reliable measures were used; however no follow u assessments were undertaken and the samles were not drawn from oulation based registries. One cross sectional Jaanese study investigated the relationshi between ersonality and rostate cancer by assessing 217 men re- biosy and then comaring cases with controls(kumano et al., 2005). Two variables were found to redict a rostate cancer diagnosis, a family history of rostate cancer (OR=4.2, ; <.05) and having a harmony seeking ersonality (OR=10.8, ; <.05). Namiki et al. (2007) assessed 340 Jaanese men who had been treated for localised rostate cancer by radical rostatectomy or radiation theray and found 2624 Asian Pacific Journal of Cancer Prevention, Vol 14, 2013 To date there has been scant research on the sychological needs of men with rostate cancer in Asian countries. Secifically, only a small number of low evidence descritive studies were found with study limitations evident with regards to samling frames and cross sectional designs. Hence, from work to date it is not ossible to draw clear conclusions about how rostate cancer imacts the sychological health of Asian men with rostate cancer and what factors lead to oorer outcomes, and this has imlications for both research and ractice. There are well described differences in how different cultural grous resent with regards to sychological distress. For examle, somatic symtoms of distress may be more commonly reorted in Chinese oulations comared to Western grous (Parker et al., 2001), and Chinese aroaches to coing that are influenced by Eastern hilosohy and cultural beliefs may be more focussed on maintaining internal control and accetance (Cheng and Chio, 2010). With regards to beliefs about cancer, in Jaanese Americans, comared to Caucasians, there is a greater association of cancer with death and less otimism about the curability of cancer that, at least
5 in art, reflects differing cultural meanings about cancer (Long and Long, 1982; Gotay et al., 2004). Given such cultural differences, the knowledge ga about redictors, mediators and revalence of negative sychological outcomes for Asian men after a rostate cancer diagnosis makes designing well targeted sychological suort interventions for this setting roblematic. From this we conclude that develoing an evidence base on how men in Asia react to and coe with a rostate cancer diagnosis, and from this how to best rovide suort, must be considered a research riority. It is concerning that there does not aear to be a consistent increase in the research effort since 2005, not only for studies addressing the sychological morbidity associated with rostate cancer in Asian men but also for quality of life studies. As well, the research undertaken aears concentrated in only a few countries, articularly Jaan. This is a concerning ga, esecially given the increasing revalence of rostate cancer in China. We suggest that this lack of research cannot be exlained only by a lower revalence of rostate cancer comared with other cancers and other countries. Historically, there has been a gender bias in sychosocial cancer survivorshi studies with men less reresented comared to women, although men s involvement in such research internationally aears to have increased substantially over the ast fifteen years (Hoyt and Rubin, 2012). It may be that as sycho-oncology research in Asia further develos the same trend will occur in the decades to come, however this may not haen without adequate resourcing. The resources that are needed to undertake well designed sychological research with Asian men with rostate cancer include valid and reliable assessment measures that are culturally relevant; researchers skilled in sycho-oncology and QOL research; rioritising of this research by health care funders and service roviders; and a willingness of men to articiate. Efforts to stimulate and suort the develoment of this caacity seem warranted. The research identified in this review does however suggest that as many as one third of men with rostate cancer in at least one Asian country (Jaan) exerience clinically high sychological distress after rostate cancer (Namiki et al., 2007). Estimates of distress in Western oulations vary (Bloch et al., 2007) and this may relate at least in art to differences in samling frames and measurement aroaches. In our revious research, and by comarison, we have found aroximately 10% of Australian men with rostate cancer to exerience clinically levels of anxiety, deression and cancer-secific distress (Chambers et al., 2013; Steginga et al., 2004); other authors have suggested that men with rostate cancer exerience increased sychological distress in the first twelve months after diagnosis with men with advanced disease exeriencing greatest distress (Couer et al., 2006). Australian studies further suggest that between a third and a half of men with rostate cancer exerience high levels of unmet needs for sychological hel and unmet information and suort needs for sexuality concerns (Steginga et al., 2001; Smith et al., 2007). Thus there may be some comarability between the distress exeriences of atients from at least these two contexts, DOI:htt://dx.doi.org/ /APJCP Psychosocial Asects of Prostate Cancer in Asia - Systematic Review although again more research is needed. It is of note that one Taiwanese study found evidence of decision regret and uncertainty after rostate cancer treatment, a finding that has been observed elsewhere (Steginga et al., 2004). Decision suort for men with rostate cancer has been a secific area of research focus in Western countries for some time where men newly diagnosed with rostate cancer will frequently be offered a range of different rostate cancer treatment modalities (e.g., radical or robotic surgery; external radiation theray; brachytheray; adjuvant androgen ablation), all with differing side effect rofiles, from which they much choose a best fit treatment otion that matches their ersonal references and values (Chambers et al., 2011; 2012; Steginga et al., 2008). This also resents as a key area for otential focus for future research in Asian atient oulations. In conclusion, the limited research to date suggests that a diagnosis of and treatment for rostate cancer has a substantive negative effect on the sychological wellbeing of men in Asia, as it does in Western countries. There is a body of knowledge already develoed in Western countries that lays a foundation from which new research with an Asian focus could be develoed, taking note of lessons already learned and ensuring cultural relevance to the oulations concerned. The develoment of a research caacity and focussed agenda that ultimately can underin the develoment of effective and culturally relevant sychological and decision suort interventions for men with rostate cancer in Asia, and their artners and families, is needed. References Baade P, Youlden DR, Cramb S, Dunn J, Gardiner RA (2012). Eidemiology of Prostate Cancer in the Asia-Pacific Region. In Press. Baade PD, Youlden DR, Krnjacki LJ (2009). 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