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1 Click for suppliers of this product Cuprate(4-), [m-[[3,3'-[[3,3'-di(hydroxy-ko)[1,1'-biphenyl]-4,4'-diyl]bis(2,1- diazenediyl-kn1)]bis[5-amino-4-(hydroxy-ko)-2,7-naphthalenedisulfonato]](8-)]]di-,sodium (1:4) (cas ) MSDS : Cuprate(4-), (mu-((3,3'-((3,3'-dihydroxy(1,1'-biphenyl)-4,4'-diyl) MSDS bis(azo))bis(5-amino- 4-hydroxy-2,7-naphthalenedisulfonato))(8-)))di-, tetrasodium CAS : SYNONYMS : * Amanil Supra Blue 9GL * C.I * C.I. Direct Blue 218 * Fastusol Blue 9GLP * NCI C60877 * Pontamine Bond Blue B * Pontamine Fast Blue 7GLN * Solantine Blue 10GL Catalog of Chemical Suppliers, Buyers, Custom Synthesis Companies And Equipment Manufacturers [ Cuprate(4-),(mu-((3,3'-((3,3'-dihydroxy(1,1'-biphenyl)-4,4'-diyl)bis(azo))bis(5-amino-4-hydroxy-2,7- naphthalenedisulfonato))(8-)))di-,tetrasodium ] *** CHEMICAL IDENTIFICATION *** RTECS NUMBER CHEMICAL NAME : GS : Cuprate(4-), (mu-((3,3'-((3,3'-dihydroxy(1,1'-biphenyl)-4,4'-diyl) bis(azo))bis(5-amino- 4-hydroxy-2,7-naphthalenedisulfonato))(8-)))di-, tetrasodium CAS REGISTRY NUMBER : OTHER CAS REGISTRY NOS. : LAST UPDATED : DATA ITEMS CITED : 17 MOLECULAR FORMULA : C32-H16-Cu2-N6-O16-S4.4Na MOLECULAR WEIGHT : WISWESSER LINE NOTATION : L66J BQ DSWO HSWO CNUNR BQ DR CQ DNUN- CL66J DSWO HSWO &-NA- 4

2 COMPOUND DESCRIPTOR : Tumorigen Mutagen SYNONYMS/TRADE NAMES : * Amanil Supra Blue 9GL * C.I * C.I. Direct Blue 218 * Fastusol Blue 9GLP * NCI C60877 * Pontamine Bond Blue B * Pontamine Fast Blue 7GLN * Solantine Blue 10GL *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** : LD50 - Lethal dose, 50 percent kill : 3290 mg/kg Details of toxic effects not reported other than lethal dose value : LDLo - Lowest published lethal dose : Rodent - rabbit : 3920 mg/kg Details of toxic effects not reported other than lethal dose value : LDLo - Lowest published lethal dose : Administration onto the skin : Rodent - rabbit : 8 gm/kg

3 Details of toxic effects not reported other than lethal dose value ** OTHER MULTIPLE DOSE TOXICITY DATA ** : mg/kg/14d-c Cardiac - changes in heart weight Endocrine - changes in thymus weight Nutritional and Gross Metabolic - weight loss or decreased weight gain : mg/kg/13w-c liver - other changes Kidney, Ureter, Bladder - changes in bladder weight Blood - pigmented or nucleated red blood cells : 50 gm/kg/14d-c Cardiac - changes in heart weight Liver - changes in liver weight Endocrine - changes in thymus weight

4 : 109 gm/kg/13w-c Nutritional and Gross Metabolic - weight loss or decreased weight gain ** TUMORIGENIC DATA ** : 438 gm/kg/2y-c Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors : 876 gm/kg/2y-c Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors ** MUTATION DATA ** TEST SYSTEM : Mutation in microorganisms : Bacteria - Salmonella typhimurium : 1 mg/plate VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V Volume(issue)/page/year: 22,413,1980

5 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M2161 No. of Facilities: 60 (estimated) No. of Industries: 4 No. of Occupations: 9 No. of Employees: 2461 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M2161 No. of Facilities: 530 (estimated) No. of Industries: 10 No. of Occupations: 13 No. of Employees: (estimated) No. of Female Employees: 4390 (estimated) *** STATUS IN U.S. *** EPA TSCA Section 8(b) CHEMICAL INVENTORY EPA TSCA Section 8(d) unpublished health/safety studies EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998 NTP Carcinogenesis studies (feed);clear evidence:mouse Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-430,94 NTP Carcinogenesis studies (feed);some evidence:rat Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-430,94 *** END OF RECORD ***