Single isomer cyclodextrins
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1 for chiral separation, studying of hostguest interaction and specific encapsulation of APIs 1
2 CycloLab offers a wide variety of selectively substituted, single isomer cyclodextrin derivatives (such as Sugammadex) excellent for selective encapsulation of target compounds, assessment and fine tuning of the interaction on the molecular level. K Nag: Sugammadex: A revolutionary drug in neuromuscular pharmacology P Tang: Dimethyl-β-cyclodextrin/salazosulfapyridine inclusion complex-loaded chitosan nanoparticles for sustained release MR Caira: Inclusion complexes of 2-methoxyestradiol with dimethylated and permethylated β-cyclodextrins: models for cyclodextrin steroid interaction 2 HL Sun: Polyanionic Cyclodextrin Induced Supramolecular Nanoparticle
3 Single isomer CDs have particular importance in chiral analytical methods where they regularly outperform their randomly substituted analogues. Gy Vigh: A Family of Single-Isomer Chiral Resolving Agents for Capillary Electrophoresis. 1. Heptakis(2,3-diacetyl-6-sulfato)-α-cyclodextrin Gy Vigh: A Family of Single-Isomer, Sulfated γ-cyclodextrin Chiral Resolving Agents for Capillary Electrophoresis. 1. ctakis(2,3-diacetyl-6-sulfato)-γ-cyclodextrin E Varga: Development of Electrophoretic Methods for Simultaneous Determination of Enantiomeric Ratio and Composition of Diastereomeric Salt Mixtures I Fejős: Comparative evaluation of the chiral recognition potential of single-isomer sulfated beta-cyclodextrin synthesis intermediates in non-aqueous capillary electrophoresis 3
4 CH 3 I Fejős: Characterization of a single isomer carboxymethyl beta cyclodextrin in chiral capillary electrophoresis G Benkovics: Single-isomer carboxymethyl-γ-cyclodextrin as chiral resolving agent for capillary electrophoresis CycloLab is deeply involved in the development of next generation single isomer compounds with substituents of essential importance like sulfobutylether groups or those Na M Malanga: Synthesis, analytical characterization and the first capillary electrophoretic use of the single-isomer heptakis-(6--sulfobutyl)-beta-cyclodextrin S 3 Na of ph-sensitive functional properties as carboxymethyl derivatives. CH 3 14 S 3 Na Bn 14 S 3 Na 4
5 Why single isomer cyclodextrins? The main advantages are: Improved batch-to-batch robustness and reproducible analytical/functional results Straightforward pharmacokinetics and toxicity More reliable prediction and outcome of chiral separations Easier assessment of functional properties and interactions on the molecular level 5
6 List of available products at CycloLab Product code Product name CY-2003 Heptakis(2,3,6-tri--methyl)-BCD CY Heptakis(2,6-di--methyl)-BCD CY Monodeoxy-6-monoamino-BCD CY-2065 Heptakis(6-deoxy-6-amino)-BCD CY-3065 ctakis(6-deoxy-6-amino)-gcd CY-2200 Heptakis(6-sulfo)-BCD CY-2201 Heptakis(2,3-di--acetyl-6-sulfo)-BCD CY-2202 Heptakis(2,3-di--methyl-6-sulfo)-BCD CY3202 ctakis(2,3-di--methyl-6-sulfo)-gcd Product Product name code CY-2211 Heptakis(6--methyl)-BCD CY-2212 Heptakis(6--carboxymethyl)-BCD CY-2213 Heptakis(2,3-di--methyl-6-carboxymethyl)-BCD CY-3213 ctakis(2,3-di--methyl-6-carboxymethyl)-gcd CY-2214 Heptakis(6--sulfobutyl)-BCD CY-2215 Heptakis(2,3-di--methyl-6-sulfobutyl)-BCD CY-2216 Heptakis(2,3-di--benzyl-6-sulfobutyl)-BCD For any other specific derivative to be designed, please reach out to us for discussion at 6
7 Company contacts: CycloLab Cyclodextrin Research & Development Laboratory Ltd. Budapest, P.. Box 435, H-1525 Hungary Location: Illatos út., Budapest, H-109 Hungary TEL: (+36) or -0; FAX: (+36) Homepage: Contact person: Zita Vincze Sales Executive Tel: (+36)
CycloLab. a cyclodextrin R&D company. Special offer
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The Separation of 8 -THC, 9 -THC, and Their Enantiomers by UPC 2 Using Trefoil Chiral Columns Jacquelyn Runco, Andrew Aubin, and Catharine Layton Waters Corporation, Milford, MA, USA APPLICATION BENEFITS