Safety Assessment of Polyglyceryl Fatty Acid Esters as Used in Cosmetics

Transcription

1 Safety Assessmet of Polyglyceryl Fatty Acid Esters as Used i Cosmetics Status: Draft eport for Pael eview elease Date: March 7, 2016 Pael Meetig Date: March 31-April 1, 2016 The 2016 Cosmetic Igrediet eview Expert Pael members are: Chairma, Wilma F. Bergfeld, M.D., F.A.C.P.; Doald V. Belsito, M.D.; oald A. ill, Ph.D.; Curtis D. Klaasse, Ph.D.; Daiel C. Liebler, Ph.D.; James G. Marks, Jr., M.D., oald C. Shak, Ph.D.; Thomas J. Slaga, Ph.D.; ad Paul W. Syder, D.V.M., Ph.D. The CI Director is Lillia J. Gill, D.P.A. This safety assessmet was prepared by Moice M. Fiume, Assistat Director/Seior Scietific Aalyst/Writer ad Bart eldreth, Ph.D., Chemist. Cosmetic Igrediet eview 1620 L Street, NW, Suite 1200 Washigto, DC ph fax cirifo@cir-safety.org

2 Distributed for Commet ly -- Do Not Cite or Quote Commitmet & Credibility sice 1976 Memoradum To: From: Date: Subject: CI Expert Pael Members ad Liaisos Moice M. Fiume MMF Assistat Director/Seiorr Scietific Aalyst March 7, 2016 Safety Assessmet of Polyglyceryl Fatty Acid Esters as Used i Cosmetics Eclosed is the Draft eport of the Safety Assessmet of Polyglyceryl Fatty Acid Esters as Used i Cosmetics (PGlyFE032016rep). This is the first time the Pael is seeig this safety assessmet of 275 igrediets that are structurally costituted of the esterificatio products of polyglyceri chais ad fatty acids. The Scietific Literature eview was issued o Jauary 19, You may recall that the Pael reviewed a fial report o the safety of the mooglyceryl mooesters i December, ad cocluded that the 44 mooglyceryl mooesters amed i that reportt are safe i the preset practices of use ad comaterials, ad cetratio. Mooglyceryl mooesters ad polyglyceryll fatty acid esters both cosist of the same startig they have the same potetial metabolites. The differece betwee these two families of igrediets is that moo- ad glyceryl mooesters are structurally costituted of the esterificatio products of oly oe equivalet of glyceri oe equivalet of a carboxylic acid, as opposed to the varyig umber of equivalets of glyceri ad fatty acids i the polyglyceryl esters. Several submissios o the maximum cocetratio of use of these igrediets by FDA product category have bee made by the Coucil. The submissios are idetified as PGlyFE032016data_1 through PGlyFE032016data_4. The followig upublished data also have bee submitted: 1. Aoymous. (2016) Compositio ad physical ad chemical properties of Polyglyceryl-4 leate (PGlyFE032016data_5); 2. Aoymous. (2016) Summary iformatio o Palm il Polyglyceryl-4 Esters, Apricot Kerel il Poly- ice Braate) ad PLIX (ice Bra il Polyglyceryl-3 Esters) (PGlyFE032016data_7); 4. Aoymous. (2009) Material safety data sheet o a trade ame mixture cotaiig 60% Polyglyceryl-10 Eicosaedioate/Tetradecaedioatee (PGlyFE032016data_8); 5. Nikko Chemicals Co., Ltd. (2016) This submissio icludess safety iformatio sheetss o several Poly- glyceryl-4 Esters, ad Polyglyceryl-3 Diisostearate (PGlyFE032016data_6); 3. Progressus s.r.l. (2015) This submissio icludes material safety data sheets for PLIX B (Polyglyceryl-3 glyceryl-10 esters (PGlyFE032016data_9); 6. Lubrizol Advaced Materials, Ic. (2007; 2016). This submissio icludes iformatio sheets for Polyglyceryl-3 Laurate, Triisostearoyl Polyglyceryl-3 Dimerr Dilioleate,, ad Diisostearoyl Polyglyceryl-3 Dimer Dilioleate (PGlyFE032106data_10); 7. Aoymous. (2016). This submissio icludes summary data sheets for Polyglyceryl-3 Isostearate, Polyglyceryl-3 Caprate, Polyglyceryl-3 Caprylate, Polyglyceryl-3 leate, Polyglyceryl-4 Caprate, ad Diisostearoyl Polyglyceryl-3 Dimer Dilioleate. (PGlyFE032016data_11); 8. Notox BV (1996); Globecrow Services LTD (1997); arla Laboratories, Ltd. (2010). This submissio icludes ski ad ocular irritatio studies ad geotoxicity studies performed by thesee 3 laboratories. Igrediets tested iclude Polyglyceryl-2 Isostearate, Polyglyceryl-4 Laurate/Sebacate, Polyglyceryl-4 Laurate/ /Succiate, ad Polyglyceryl-6 Caprylate/Caprate. (PGlyFE032106data_12); ad 1620 L Street, NW, Suite 1200, Washigto, DC (Mai) (Fax) ( ) cirifo@cir-safety.org (Website)

3 Distributed for Commet ly -- Do Not Cite or Quote 9. Evoik. (2016) Power poit of geeral iformatio o polyglyceryl esters, etitled Polyglycerol esterificatio for highly effective ad atural-based igrediets. (PGlyFE032016data_13). The report curretly icludes 2015 FDA VCP data (PGlyFE032016FDA). The ext iteratio of the report will be updated to iclude the 2016 VCP data. Commets o the SL (PGlyFE032016pcpc) were received from the Coucil ad have bee addressed. If the data icluded i this report adequately addresses the safety of the polyglyceryl fatty acid esters, the Pael should be prepared to formulate a tetative coclusio, provide the ratioale to be described i the Discussio, ad issue a Tetative eport for public commet. If the data are ot sufficiet for makig a determiatio of safety, the a Isufficiet Data Aoucemet should be issued that provides a listig of the additioal data that are eeded.

4 Distributed for Commet ly -- Do Not Cite or Quote SAFETY ASSESSMENT FLW CAT INGEDIENT/FAMILY Polyglyceryl Fatty Acid Esterss MEETING Mar 2016 Public Commet CI Expert Pael eport Status Priority List INGEDIENT PIITY LIST SL Ja 19, 2016 DAFTT EPT Mar day public commet period Draft eport Table Table IDA T IDA Notice Draft T IDA DAFT TENTATIVE EPTT Table Table Tetative eport Issue T 60 day Public commet period Draft F DAFT FINAL EPT Table Table Differet Coclusio PUBLIS Fial eport Issue F

5 Distributed for Commet ly -- Do Not Cite or Quote Polyglyceryl Fatty Acid Esters Data Profile March 2016 Moice Fiume eported Use Method of Mfg Impurities Toxicokietics Dermal Peetratio Aimal Tox Acute, Dermal Aimal Tox Acute, ral Aimal Tox, Acute, Ihalatio Aimal Tox ptd Dose, Dermal Aimal Tox, ptd Dose, ral Aimal Tox ptd Dose, Ihalatio epro/dev Toxicity Geotoxicity Carciogeicity Dermal Irr/Ses Case eports cular Irritatio Mucous Membrae Irr geeral Polyglyceryl Fatty Acid Esters X X X X X X X geeral Polyglyceryl Stearate X Polyglyceryl Mooesters Polyglyceryl-2 Caprate X Polyglyceryl-2 Caprylate Polyglyceryl-2 Laurate X Polyglyceryl-2 Myristate Polyglyceryl-2 Isopalmitate X Polyglyceryl-2 Palmitate Polyglyceryl-2 Isostearate X X Polyglyceryl-2 leate X X Polyglyceryl-2 Stearate X Polyglyceryl-2 Isopalmitate/Sebacate Polyglyceryl-3 Caprate X X X X X Polyglyceryl-3 Caprylate X X X X X Polyglyceryl-3 Laurate X X X X Polyglyceryl-3 Myristate Polyglyceryl-3 Palmitate Polyglyceryl-3 Isostearate X X X X X Polyglyceryl-3 leate X X X X X Polyglyceryl-3 Stearate X Polyglyceryl-3 Stearate SE Polyglyceryl-3 icioleate X Polyglyceryl-3 Beheate Acacia Decurres/Jojoba/Suflower Seed Wax X Polyglyceryl 3 Esters Apricot Kerel il Polyglyceryl-3 Esters Cadelilla/Jojoba/ice Bra Polyglyceryl-3 Esters X live il Polyglyceryl-3 Esters Palm il Polyglyceryl-3 Esters Polyglyceryl-3 Beeswax X Polyglyceryl-3 Cocoate Polyglyceryl-3 ice Braate Polyglyceryl-3 Soyate/Shea Butterate ice Bra il Polyglyceryl-3 Esters Shea Butter Polyglyceryl-3 Esters Suflower Seed il Polyglyceryl-3 Esters Polyglyceryl-4 Caprate X X Polyglyceryl-4 Caprylate X X X X Polyglyceryl-4 Laurate X X X Polyglyceryl-4 Isostearate X X X Polyglyceryl-4 leate X X

6 Distributed for Commet ly -- Do Not Cite or Quote Polyglyceryl Fatty Acid Esters Data Profile March 2016 Moice Fiume eported Use Method of Mfg Impurities Toxicokietics Dermal Peetratio Aimal Tox Acute, Dermal Aimal Tox Acute, ral Aimal Tox, Acute, Ihalatio Aimal Tox ptd Dose, Dermal Aimal Tox, ptd Dose, ral Aimal Tox ptd Dose, Ihalatio epro/dev Toxicity Geotoxicity Carciogeicity Dermal Irr/Ses Case eports cular Irritatio Mucous Membrae Irr Polyglyceryl-4 Stearate Apricot Kerel il Polyglyceryl-4 Esters X X Babassu il Polyglyceryl-4 Esters X Borage Seed il Polyglyceryl-4 Esters Liseed il Polyglyceryl-4 Esters live il Polyglyceryl-4 Esters Palm Kerel il Polyglyceryl-4 Esters Palm il Polyglyceryl-4 Esters X X X Polyglyceryl-4 Almodate/Shea Butterate Polyglyceryl-4 Caprylate/Caprate Polyglyceryl-4 Cocoate Polyglyceryl-4 azelutseedate Polyglyceryl-4 Isostearate/Laurate Polyglyceryl-4 Laurate/Sebacate X X Polyglyceryl-4 Laurate/Succiate X X X Polyglyceryl-4 Puicate Polyglyceryl-4 Sweet Almodate Shea Butter Polyglyceryl-4 Esters Suflower Seed il Polyglyceryl-4 Esters Sweet Almod il Polyglyceryl-4 Esters Polyglyceryl-5 Caprate Polyglyceryl-5 Laurate X Polyglyceryl-5 Myristate Polyglyceryl-5 Isostearate X Polyglyceryl-5 leate X Polyglyceryl-5 Stearate X Polyglyceryl-5 icioleate Apricot Kerel il Polyglyceryl-5 Esters Palm il Polyglyceryl-5 Esters Suflower Seed il Polyglyceryl-5 Esters Polyglyceryl-6 Caprate Polyglyceryl-6 Caprylate Polyglyceryl-6 Udecyleate Polyglyceryl-6 Laurate Polyglyceryl-6 Myristate Polyglyceryl-6 Palmitate Polyglyceryl-6 Isostearate X Polyglyceryl-6 leate X Polyglyceryl-6 Stearate Polyglyceryl-6 icioleate Polyglyceryl-6 Beheate X

7 Distributed for Commet ly -- Do Not Cite or Quote Polyglyceryl Fatty Acid Esters Data Profile March 2016 Moice Fiume eported Use Method of Mfg Impurities Toxicokietics Dermal Peetratio Aimal Tox Acute, Dermal Aimal Tox Acute, ral Aimal Tox, Acute, Ihalatio Aimal Tox ptd Dose, Dermal Aimal Tox, ptd Dose, ral Aimal Tox ptd Dose, Ihalatio epro/dev Toxicity Geotoxicity Carciogeicity Dermal Irr/Ses Case eports cular Irritatio Mucous Membrae Irr Adasoia Digitata Seed il Polyglyceryl-6 Esters Apricot Kerel il Polyglyceryl-6 Esters Arga il Polyglyceryl-6 Esters Astrocaryum Vulgare il Polyglyceryl-6 Esters Avocado il Polyglyceryl-6 Esters Babassu il Polyglyceryl-6 Esters X Bertholletia Excelsa Seed il Polyglyceryl-6 Esters Borage Seed il Polyglyceryl-6 Esters Carapa Guaiaesis il Polyglyceryl-6 Esters Castor il Polyglyceryl-6 Esters Cocoa Butter Polyglyceryl-6 Esters Cocout il Polyglyceryl-6 Esters X Coffee Seed il Polyglyceryl-6 Esters Glyceryl/Polyglyceryl-6 Isostearate/Beheate Esters X azelut Seed il Polyglyceryl-6 Esters Macadamia Seed il Polyglyceryl-6 Esters X Mauritia Flexuosa Seed il Polyglyceryl-6 Esters live il Polyglyceryl-6 Esters Palm il Polyglyceryl-6 Esters Pariari Curatellifolia il Polyglyceryl-6 Esters Pius Sibirica Seed il Polyglyceryl-6 Esters Polyglyceryl-6 Adasoia Digitata Seedate Polyglyceryl-6 Apricot Kerelate Polyglyceryl-6 Arga Kerelate Polyglyceryl-6 Caprylate/Caprate X X X X Polyglyceryl-6 Citrullus Laatus Seedate Polyglyceryl-6 Palmitate/Succiate Polyglyceryl-6 Schiziophyto autaeii Kerelate Polyglyceryl-6 Sclerocarya Birrea Seedate Polyglyceryl-6 Trichilia Emetica Seedate Polyglyceryl-6 Ximeia Americaa Seedate osa ubigiosa Seed il Polyglyceryl-6 Esters Safflower Seed il Polyglyceryl-6 Esters Schiziophyto autaeii Kerel il Polyglyceryl-6 Esters Sclerocarya Birrea Seed il Polyglyceryl-6 Esters Sesame il Polyglyceryl-6 Esters Shea Butter Polyglyceryl-6 Esters Soybea il Polyglyceryl-6 Esters Suflower Seed il Polyglyceryl-6 Esters Sweet Almod il Polyglyceryl-6 Esters Theobroma Gradiflorum Seed Butter Polyglyceryl-6

8 Distributed for Commet ly -- Do Not Cite or Quote Polyglyceryl Fatty Acid Esters Data Profile March 2016 Moice Fiume eported Use Method of Mfg Impurities Toxicokietics Dermal Peetratio Aimal Tox Acute, Dermal Aimal Tox Acute, ral Aimal Tox, Acute, Ihalatio Aimal Tox ptd Dose, Dermal Aimal Tox, ptd Dose, ral Aimal Tox ptd Dose, Ihalatio epro/dev Toxicity Geotoxicity Carciogeicity Dermal Irr/Ses Case eports cular Irritatio Mucous Membrae Irr Esters Trichilia Emetica Seed il Polyglyceryl-6 Esters Watermelo Seed il Polyglyceryl-6 Esters Ximeia Americaa Seed il Polyglyceryl-6 Esters Polyglyceryl-8 leate Polyglyceryl-8 Stearate Polyglyceryl-8 C12-20 Acid Ester Polyglyceryl-10 Caprate Polyglyceryl-10 Caprylate Polyglyceryl-10 Udecyleate Polyglyceryl-10 Laurate X X X X Polyglyceryl-10 Myristate X X X X Polyglyceryl-10 Palmitate Polyglyceryl-10 Isostearate X Polyglyceryl-10 Lioleate Polyglyceryl-10 leate X X Polyglyceryl-10 Stearate X X X Almod il/polyglyceryl-10 Esters Apricot Kerel il Polyglyceryl-10 Esters Caprylic/Capric Glycerides Polyglyceryl-10 Esters Polyglyceryl-10 Apricot Kerelate Polyglyceryl-10 Beheate/Eicosadioate X Polyglyceryl-10 Caprylate/Caprate Polyglyceryl-10 Cocoate Polyglyceryl-10 Eicosaedioate/Tetradecaedioate X X Polyglyceryl-10 ydroxystearate/stearate/ X Eicosadioate Polyglyceryl-10 Palmate Sclerocarya Birrea Seed il Polyglyceryl-10 Esters Suflower Seed il Polyglyceryl-10 Esters Watermelo Seed il Polyglyceryl-10 Esters Polyglyceryl Multi-Esters Polyglyceryl-2 Sesquicaprylate Polyglyceryl-2 Sesquiisostearate X X Polyglyceryl-2 Diisostearate X X X X X X X Polyglyceryl-2 Triisostearate X Polyglyceryl-2 Tetraisostearate X Polyglyceryl-2 Dioleate X Polyglyceryl-2 Sesquioleate Polyglyceryl-2 Tetraoleate Polyglyceryl-2 Sesquistearate X Polyglyceryl-2 Distearate

9 Distributed for Commet ly -- Do Not Cite or Quote Polyglyceryl Fatty Acid Esters Data Profile March 2016 Moice Fiume eported Use Method of Mfg Impurities Toxicokietics Dermal Peetratio Aimal Tox Acute, Dermal Aimal Tox Acute, ral Aimal Tox, Acute, Ihalatio Aimal Tox ptd Dose, Dermal Aimal Tox, ptd Dose, ral Aimal Tox ptd Dose, Ihalatio epro/dev Toxicity Geotoxicity Carciogeicity Dermal Irr/Ses Case eports cular Irritatio Mucous Membrae Irr Polyglyceryl-2 Tetrastearate Polyglyceryl-2 Tetrabeheate/ Macadamiate/Sebacate Polyglyceryl-3 Dicaprate Polyglyceryl-3 Diisostearate X X X X X X Polyglyceryl-3 Triisostearate Polyglyceryl-3 Dioleate Polyglyceryl-3 Distearate X Polyglyceryl-3 Di-ydroxystearate Polyglyceryl-3 Petaricioleate X Diisostearoyl Polyglyceryl-3 Dimer Dilioleate X X X X X X Polyglyceryl-3 Dicitrate/Stearate X Polyglyceryl-3 Dicocoate Polyglyceryl-3 Petacaprylate/Caprate Polyglyceryl-3 Petaolivate Polyglyceryl-3 Triolivate Triisostearoyl Polyglyceryl-3 Dimer Dilioleate X X X Polyglyceryl-4 Dilaurate Polyglyceryl-4 Petaoleate Polyglyceryl-4 Distearate Polyglyceryl-4 Tristearate Polyglyceryl-4 Petastearate Polyglyceryl-4 Petapalmitate/Stearate Pumpki Seed il Polyglyceryl-4 Esters Pumpki Seed il Polyglyceryl-4 Esters Succiate Polyglyceryl-5 Dicaprylate Polyglyceryl-5 Dilaurate Polyglyceryl-5 Trimyristate Polyglyceryl-5 Petamyristate Polyglyceryl-5 Triisostearate X Polyglyceryl-5 Dioleate X Polyglyceryl-5 Trioleate X Polyglyceryl-5 Tristearate Polyglyceryl-5 exastearate Polyglyceryl-5 Tribeheate Polyglyceryl-6 Sesquicaprylate Polyglyceryl-6 Dicaprate Polyglyceryl-6 Tricaprylate X Polyglyceryl-6 Tetracaprylate Polyglyceryl-6 Petacaprylate Polyglyceryl-6 eptacaprylate Polyglyceryl-6 ctacaprylate Polyglyceryl-6 Dipalmitate

10 Distributed for Commet ly -- Do Not Cite or Quote Polyglyceryl Fatty Acid Esters Data Profile March 2016 Moice Fiume eported Use Method of Mfg Impurities Toxicokietics Dermal Peetratio Aimal Tox Acute, Dermal Aimal Tox Acute, ral Aimal Tox, Acute, Ihalatio Aimal Tox ptd Dose, Dermal Aimal Tox, ptd Dose, ral Aimal Tox ptd Dose, Ihalatio epro/dev Toxicity Geotoxicity Carciogeicity Dermal Irr/Ses Case eports cular Irritatio Mucous Membrae Irr Polyglyceryl-6 Sesquiisostearate Polyglyceryl-6 Diisostearate Polyglyceryl-6 Dioleate X Polyglyceryl-6 Tetraoleate Polyglyceryl-6 Petaoleate Polyglyceryl-6 exaoleate Polyglyceryl-6 Sesquistearate Polyglyceryl-6 Distearate X X Polyglyceryl-6 Tristearate Polyglyceryl-6 Petastearate X Polyglyceryl-6 exastearate Polyglyceryl-6 ctastearate X Polyglyceryl-6 Petaricioleate Polyglyceryl-6 Tetrabeheate Macadamia Seed il Polyglyceryl-6 Esters Beheate Polyglyceryl-8 Decabeheate/Caprate X Polyglyceryl-8 Decaerucate/Decaisostearate/ X Decaricioleate Polyglyceryl-10 Decaethylhexaoate Polyglyceryl-10 Dodecacaprate Polyglyceryl-10 Petacaprylate Polyglyceryl-10 Dodecacaprylate Polyglyceryl-10 Tridecaoate Polyglyceryl-10 Dilaurate Polyglyceryl-10 Trilaurate Polyglyceryl-10 Tetralaurate Polyglyceryl-10 Petalaurate Polyglyceryl-10 Dimyristate Polyglyceryl-10 Dipalmitate X Polyglyceryl-10 Diisostearate X X Polyglyceryl-10 Triisostearate Polyglyceryl-10 Petaisostearate X X Polyglyceryl-10 exaisostearate Polyglyceryl-10 Noaisostearate X Polyglyceryl-10 Decaisostearate X Polyglyceryl-10 Petalioleate Polyglyceryl-10 Decalioleate Polyglyceryl-10 Dioleate X Polyglyceryl-10 Trioleate Polyglyceryl-10 Tetraoleate Polyglyceryl-10 Petaoleate X Polyglyceryl-10 Petaricioleate

11 Distributed for Commet ly -- Do Not Cite or Quote Polyglyceryl Fatty Acid Esters Data Profile March 2016 Moice Fiume eported Use Method of Mfg Impurities Toxicokietics Dermal Peetratio Aimal Tox Acute, Dermal Aimal Tox Acute, ral Aimal Tox, Acute, Ihalatio Aimal Tox ptd Dose, Dermal Aimal Tox, ptd Dose, ral Aimal Tox ptd Dose, Ihalatio epro/dev Toxicity Geotoxicity Carciogeicity Dermal Irr/Ses Case eports cular Irritatio Mucous Membrae Irr Polyglyceryl-10 exaoleate Polyglyceryl-10 eptaoleate Polyglyceryl-10 Decaoleate X X X X Polyglyceryl-10 Distearate X Polyglyceryl-10 Tristearate x Polyglyceryl-10 Petastearate X Polyglyceryl-10 Petahydroxystearate X Polyglyceryl-10 eptahydroxystearate X Polyglyceryl-10 eptastearate Polyglyceryl-10 Decahydroxystearate Polyglyceryl-10 Decastearate Polyglyceryl-10 Dodecabeheate Polyglyceryl-10 Trierucate Polyglyceryl-10 exaerucate Polyglyceryl-10 Noaerucate Polyglyceryl-10 Decamacadamiate Polyglyceryl-10 Dicocoate Polyglyceryl-10 Didecaoate Polyglyceryl-10 Dodeca-Caprylate/ Caprate Polyglyceryl-10 epta(beheate/stearate) Polyglyceryl-10 Moo/Dioleate Polyglyceryl-10 Sesquistearate Polyglyceryl-10 Tetradecaedioate Polyglyceryl-10 Tricocoate Polyglyceryl-15 Diisostearate Polyglyceryl-20 exacaprylate Polyglyceryl-20 eptacaprylate Polyglyceryl-20 ctaisooaoate Polyglyceryl-20 Docosabeheate/Isostearate Polyglyceryl-20 Docosabeheate/Laurate Polyglyceryl-20 Docosabeheate/leate Polyglyceryl-20 eptadecabeheate/laurate Polyglyceryl-20 ctadecabeheate/laurate

12 Distributed for Commet ly -- Do Not Cite or Quote Polyglyceryl Fatty Acid Esters CAS # Use IfoBase PubMed SciFider ChemID NTIS FDA ECA PV IUCLID/ SIDS W/ JEFCA EU NICNAS Web Geeric terms, Polyglyceryl Fatty Acid Esters, etc X X --- CF --- X Acacia Decurres/Jojoba/ Suflower Seed o r X Wax Polyglyceryl 3 Esters Adasoia Digitata Seed il Polyglyceryl o r --- X Esters Almod il/polyglyceryl-10 Esters o r --- Apricot Kerel il Polyglyceryl-10 Esters o r --- X Apricot Kerel il Polyglyceryl-3 Esters o r Apricot Kerel il Polyglyceryl-4 Esters (Dub Aprilose +) o r Apricot Kerel il Polyglyceryl-5 Esters o r Apricot Kerel il Polyglyceryl-6 Esters o r --- X Arga il Polyglyceryl-6 Esters o r --- X Astrocaryum Vulgare il Polyglyceryl o r Esters Avocado il Polyglyceryl-6 Esters o r Babassu il Polyglyceryl-4 Esters o r --- X Babassu il Polyglyceryl-6 Esters o r --- X Bertholletia Excelsa Seed il Polyglyceryl-6 Esters o r --- X Borage Seed il Polyglyceryl-4 Esters o r Borage Seed il Polyglyceryl-6 Esters o r --- X Cadelilla/Jojoba/ice Bra Polyglyceryl o r Esters Caprylic/Capric Glycerides Polyglyceryl o r X Esters ( Carapa Guaiaesis il Polyglyceryl o r Esters ( Castor il Polyglyceryl-6 Esters o r --- X Cocoa Butter Polyglyceryl-6 Esters o r --- X Cocout il Polyglyceryl-6 Esters o r X Coffee Seed il Polyglyceryl-6 Esters o r Diisostearoyl Polyglyceryl-3 Dimer Dilioleate o r X Glyceryl/Polyglyceryl-6 Isostearate/ o r Beheate Esters azelut Seed il Polyglyceryl-6 Esters o r X Liseed il Polyglyceryl-4 Esters o r Macadamia Seed il Polyglyceryl 6 Esters o r --- X

13 Distributed for Commet ly -- Do Not Cite or Quote CAS # Use IfoBase PubMed SciFider ChemID NTIS FDA ECA PV IUCLID/ SIDS W/ JEFCA EU NICNAS Web Macadamia Seed il Polyglyceryl 6 Esters o r --- Beheate Mauritia Flexuosa Seed il Polyglyceryl o r Esters live il Polyglyceryl-3 Esters o r --- live il Polyglyceryl-4 Esters o r --- X live il Polyglyceryl-6 Esters o r X Palm Kerel il Polyglyceryl-4 Esters o r Palm il Polyglyceryl-3 Esters o r --- Palm il Polyglyceryl-4 Esters o r Palm il Polyglyceryl-5 Esters o r Palm il Polyglyceryl-6 Esters o r Pariari Curatellifolia il Polyglyceryl o r Esters Pius Sibirica Seed il Polyglyceryl o r Esters Polyglyceryl-10 Apricot Kerelate CF o r --- X Polyglyceryl-10 Beheate/Eicosadioate o r --- X Polyglyceryl-10 Caprate o r Polyglyceryl-10 Caprylate o r Polyglyceryl-10 Caprylate/Caprate o r --- X Polyglyceryl-10 Cocoate o r Polyglyceryl-10 Decaethylhexaoate o r --- Polyglyceryl-10 Decahydroxystearate o r X Polyglyceryl-10 Decaisostearate o r X Polyglyceryl-10 Decalioleate o r --- Polyglyceryl-10 Decamacadamiate X o r --- Polyglyceryl-10 Decaoleate X pre o r X Polyglyceryl-10 Decastearate X o r --- Polyglyceryl-10 Dicocoate X o r --- Polyglyceryl-10 Didecaoate o r --- Polyglyceryl-10 Diisostearate ; --- X o r X (geeric) Polyglyceryl-10 Dilaurate o r --- Polyglyceryl-10 Dimyristate o r --- Polyglyceryl-10 Dioleate X o r X Polyglyceryl-10 Dipalmitate X o r X Polyglyceryl-10 Distearate X o r X Polyglyceryl-10 Dodecabeheate o r --- Polyglyceryl-10 Dodecacaprate o r --- Polyglyceryl-10 Dodecacaprylate o r ---

14 Distributed for Commet ly -- Do Not Cite or Quote CAS # Use IfoBase PubMed SciFider ChemID NTIS FDA ECA PV IUCLID/ SIDS W/ JEFCA EU NICNAS Web Polyglyceryl-10 Dodeca-Caprylate/Caprate o r --- Polyglyceryl-10 Eicosaedioate/ Tetradecaedioate o r --- X Polyglyceryl-10 epta(beheate/stearate) o r --- Polyglyceryl-10 eptahydroxystearate o r --- Polyglyceryl-10 eptaoleate X o r --- Polyglyceryl-10 eptastearate X o r X Polyglyceryl-10 exaerucate o r --- Polyglyceryl-10 exaisostearate o r --- Polyglyceryl-10 exaoleate X o r --- Polyglyceryl-10 ydroxystearate/ o r Stearate/Eicosadioate Polyglyceryl-10 Isostearate o r Polyglyceryl-10 Laurate X X o r --- X (geeric) Polyglyceryl-10 Lioleate o r Polyglyceryl-10 Moo/Dioleate o r X Polyglyceryl-10 Myristate o r X Polyglyceryl-10 Noaerucate o r --- Polyglyceryl-10 Noaisostearate o r Polyglyceryl-10 leate ; X pre o r --- X (geeric) Polyglyceryl-10 Palmate o r --- X Polyglyceryl-10 Palmitate o r Polyglyceryl-10 Petacaprylate o r Polyglyceryl-10 Petahydroxystearate X o r --- X Polyglyceryl-10 Petaisostearate o r Polyglyceryl-10 Petalaurate X o r Polyglyceryl-10 Petalioleate o r Polyglyceryl-10 Petaoleate X o r Polyglyceryl-10 Petaricioleate o r Polyglyceryl-10 Petastearate o r Polyglyceryl-10 Sesquistearate o r Polyglyceryl-10 Stearate X X pre o r --- X Polyglyceryl-10 Tetradecaedioate o r Polyglyceryl-10 Tetralaurate o r Polyglyceryl-10 Tetraoleate X pre o r --- X Polyglyceryl-10 Tricocoate X o r Polyglyceryl-10 Tridecaoate o r Polyglyceryl-10 Trierucate o r

15 Distributed for Commet ly -- Do Not Cite or Quote CAS # Use IfoBase PubMed SciFider ChemID NTIS FDA ECA PV IUCLID/ SIDS W/ JEFCA EU NICNAS Web Polyglyceryl-10 Triisostearate o r Polyglyceryl-10 Trilaurate o r Polyglyceryl-10 Trioleate X o r Polyglyceryl-10 Tristearate X o r Polyglyceryl-10 Udecyleate o r Polyglyceryl-15 Diisostearate o r Polyglyceryl-2 Caprate Pre o r X Polyglyceryl-2 Caprylate o r --- Polyglyceryl-2 Diisostearate ; --- X --- X o r --- X (geeric) Polyglyceryl-2 Dioleate ; pre o r Polyglyceryl-2 Distearate pre o r Polyglyceryl-2 Isopalmitate o r Polyglyceryl-2 Isopalmitate/Sebacate o r --- X Polyglyceryl-2 Isostearate Pre o r --- X Polyglyceryl-2 Laurate ; --- Pre o r --- X (geeric) Polyglyceryl-2 Myristate o r --- Polyglyceryl-2 leate X o r --- X (geeric); Polyglyceryl-2 Palmitate o r Polyglyceryl-2 Sesquicaprylate o r --- Polyglyceryl-2 Sesquiisostearate o r --- X (ostaceri DGI) Polyglyceryl-2 Sesquioleate o r Polyglyceryl-2 Sesquistearate o r Polyglyceryl-2 Stearate (geeric) pre o r --- X Polyglyceryl-2 Tetrabeheate/ o r Macadamiate/Sebacate Polyglyceryl-2 Tetraisostearate o r --- X Polyglyceryl-2 Tetraoleate o r Polyglyceryl-2 Tetrastearate pre o r --- X Polyglyceryl-2 Triisostearate pre o r Polyglyceryl-20 Docosabeheate/ Isostearate o r --- Polyglyceryl-20 Docosabeheate/Laurate o r ---

16 Distributed for Commet ly -- Do Not Cite or Quote CAS # Use IfoBase PubMed SciFider ChemID NTIS FDA ECA PV IUCLID/ SIDS W/ JEFCA EU NICNAS Web Polyglyceryl-20 Docosabeheate/leate o r --- Polyglyceryl-20 eptacaprylate o r --- Polyglyceryl-20 eptadecabeheate/ o r Laurate Polyglyceryl-20 exacaprylate o r Polyglyceryl-20 ctadecabeheate/laurate o r Polyglyceryl-20 ctaisooaoate o r Polyglyceryl-3 Beeswax o r X Polyglyceryl-3 Beheate o r X Polyglyceryl-3 Caprate ; --- Pre o r --- X ; Polyglyceryl-3 Caprylate o r --- X Polyglyceryl-3 Cocoate X --- o r --- Polyglyceryl-3 Di ydroxystearate o r X Polyglyceryl-3 Dicaprate o r --- Polyglyceryl-3 Dicitrate/Stearate o r --- Polyglyceryl-3 Dicocoate X o r --- Polyglyceryl-3 Diisostearate ; --- X o r X (geeric) Polyglyceryl-3 Dioleate X X pre o r --- X Polyglyceryl-3 Distearate X o Polyglyceryl-3 Isostearate o --- Polyglyceryl-3 Laurate X o --- X Polyglyceryl-3 Myristate X o Polyglyceryl-3 leate ; (geeric) X Pre o --- X Polyglyceryl-3 Palmitate X o X Polyglyceryl-3 Petacaprylate/Caprate --- o Polyglyceryl-3 Petaolivate o X Polyglyceryl-3 Petaricioleate o Polyglyceryl-3 ice Braate o --- X Polyglyceryl-3 icioleate Pre o X Polyglyceryl-3 Soyate/Shea Butterate *** o --- X Polyglyceryl-3 Stearate ; ; (geeric) --- X pre o --- X

17 Distributed for Commet ly -- Do Not Cite or Quote CAS # Use IfoBase PubMed SciFider ChemID NTIS FDA ECA PV IUCLID/ SIDS W/ JEFCA EU NICNAS Web Polyglyceryl-3 Stearate SE o Polyglyceryl-3 Triisostearate o Polyglyceryl-3 Triolivate o Polyglyceryl-4 Almodate/Shea Butterate o Polyglyceryl-4 Caprate ; Pre o --- X Polyglyceryl-4 Caprylate o Polyglyceryl-4 Caprylate/Caprate o --- Polyglyceryl-4 Cocoate X o --- X Polyglyceryl-4 Dilaurate o Polyglyceryl-4 Distearate o Polyglyceryl-4 azelutseedate o Polyglyceryl-4 Isostearate ; X o --- X Polyglyceryl-4 Isostearate/Laurate o Polyglyceryl-4 Laurate ; (geeric) o X X Polyglyceryl-4 leate X o Polyglyceryl-4 Petaoleate X o Polyglyceryl-4 Petapalmitate/Stearate o Polyglyceryl-4 Petastearate o Polyglyceryl-4 Puicate o Polyglyceryl-4 Stearate ; --- X pre o ; (geeric) Polyglyceryl-4 Sweet Almodate o Polyglyceryl-4 Tristearate X o Polyglyceryl-5 Caprate o --- Polyglyceryl-5 Dicaprylate o Polyglyceryl-5 Dilaurate o Polyglyceryl-5 Dioleate X o X Polyglyceryl-5 exastearate X o Polyglyceryl-5 Isostearate o Polyglyceryl-5 Laurate ; (geeric) --- X o --- X Polyglyceryl-5 Myristate X o Polyglyceryl-5 leate X pre o --- X

18 Distributed for Commet ly -- Do Not Cite or Quote CAS # Use IfoBase PubMed SciFider ChemID NTIS FDA ECA PV IUCLID/ SIDS W/ JEFCA EU NICNAS Web Polyglyceryl-5 Petamyristate o Polyglyceryl-5 icioleate o Polyglyceryl-5 Stearate X pre o (geeric) Polyglyceryl-5 Tribeheate o Polyglyceryl-5 Triisostearate o Polyglyceryl-5 Trimyristate o Polyglyceryl-5 Trioleate X o Polyglyceryl-5 Tristearate o (geeric) Polyglyceryl-6 Adasoia Digitata Seedate o r --- Polyglyceryl-6 Apricot Kerelate o r X Polyglyceryl-6 Arga Kerelate --- o r X Polyglyceryl-6 Beheate o Polyglyceryl-6 Caprate o Polyglyceryl-6 Caprylate o --- X Polyglyceryl-6 Caprylate/Caprate o Polyglyceryl-6 Citrullus Laatus Seedate o Polyglyceryl-6 Dicaprate o r Polyglyceryl-6 Diisostearate o r Polyglyceryl-6 Dioleate X o r Polyglyceryl-6 Dipalmitate X o r Polyglyceryl-6 Distearate X o r X Polyglyceryl-6 eptacaprylate o r Polyglyceryl-6 exaoleate X o r Polyglyceryl-6 exastearate X o r Polyglyceryl-6 Isostearate o Polyglyceryl-6 Laurate X o Polyglyceryl-6 Myristate X o Polyglyceryl-6 ctacaprylate o r Polyglyceryl-6 ctastearate o r X Polyglyceryl-6 leate ; --- X pre o Polyglyceryl-6 Palmitate X o Polyglyceryl-6 Palmitate/Succiate o Polyglyceryl-6 Petacaprylate o r Polyglyceryl-6 Petaoleate X o r Polyglyceryl-6 Petaricioleate o r Polyglyceryl-6 Petastearate o r Polyglyceryl-6 icioleate o Polyglyceryl-6 Schiziophyto autaeii Kerelate o r

19 Distributed for Commet ly -- Do Not Cite or Quote CAS # Use IfoBase PubMed SciFider ChemID NTIS FDA ECA PV IUCLID/ SIDS W/ JEFCA EU NICNAS Web Polyglyceryl-6 Sclerocarya Birrea Seedate o r Polyglyceryl-6 Sesquicaprylate ; o r ; Polyglyceryl-6 Sesquiisostearate o r Polyglyceryl-6 Sesquistearate o r Polyglyceryl-6 Stearate X o Polyglyceryl-6 Tetrabeheate o r Polyglyceryl-6 Tetracaprylate o r Polyglyceryl-6 Tetraoleate X o r Polyglyceryl-6 Tricaprylate o r Polyglyceryl-6 Trichilia Emetica Seedate o r Polyglyceryl-6 Tristearate X o r Polyglyceryl-6 Udecyleate o Polyglyceryl-6 Ximeia Americaa Seedate o r Polyglyceryl-8 C12-20 Acid Ester o r Polyglyceryl-8 Decabeheate/Caprate o r Polyglyceryl-8 Decaerucate/Decaisostearate/ o r Decaricioleate Polyglyceryl-8 leate ; --- X o r Polyglyceryl-8 Stearate ; X o r Pumpki Seed il Polyglyceryl-4 Esters o r --- (Ecobod PK) Pumpki Seed il Polyglyceryl-4 Esters o r Succiate ice Bra il Polyglyceryl-3 Esters (Prolix o r --- ) osa ubigiosa Seed il Polyglyceryl o r --- Esters (Viateza ose P6) Safflower Seed il Polyglyceryl-6 Esters o r X (Viateza Safflower P6) Schiziophyto autaeii Kerel il o r X Polyglyceryl-6 Esters (Viateza Mogogo P6) Sclerocarya Birrea Seed il Polyglyceryl o r X Esters Sclerocarya Birrea Seed il Polyglyceryl o r --- Esters Sesame il Polyglyceryl-6 Esters o r X Shea Butter Polyglyceryl-3 Esters o r --- Shea Butter Polyglyceryl-4 Esters ot listed Shea Butter Polyglyceryl-6 Esters o r X

20 Distributed for Commet ly -- Do Not Cite or Quote CAS # Use IfoBase PubMed SciFider ChemID NTIS FDA ECA PV IUCLID/ SIDS W/ JEFCA EU NICNAS Web Soybea il Polyglyceryl-6 Esters o r X Suflower Seed il Polyglyceryl-10 Esters o r X Suflower Seed il Polyglyceryl-3 Esters o r --- Suflower Seed il Polyglyceryl-4 Esters o r Suflower Seed il Polyglyceryl-5 Esters o r Suflower Seed il Polyglyceryl-6 Esters o r X Sweet Almod il Polyglyceryl-4 Esters o r Sweet Almod il Polyglyceryl-6 Esters o r X Theobroma Gradiflorum Seed Butter o r --- Polyglyceryl-6 Esters Trichilia Emetica Seed il Polyglyceryl o r X Esters Triisostearoyl Polyglyceryl-3 Dimer o r X Dilioleate Watermelo Seed il Polyglyceryl 10 Esters o r --- ) Watermelo Seed il Polyglyceryl 6 Esters o r X Ximeia Americaa Seed il Polyglyceryl-6 Esters o r X

21 Distributed for Commet ly -- Do Not Cite or Quote SciFider : Polyglyceryl 199 hits/4 useful Esterificatio products of glyceri ad fatty acids 456 hits CAS # AND polyglycerol esters AND polyglyceri esters AND glycerol esters, without polyglyceryl 1256 hits efie so oly Eglish 895 hits PubMed : Polyglyceryl 31 hits/2 useful Polyglycerol ad ester# - 84 hits (glycerol AND ((fatty AND acid) ester)) AND (toxic# dermal sesitiz# sesitis# irita# carcioge# mutage# geotoxic# teratoge#) 508 ITS

22 Distributed for Commet ly -- Do Not Cite or Quote [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] [EC/N Number] 0 hits

23 Distributed for Commet ly -- Do Not Cite or Quote Safety Assessmet of Polyglyceryl Fatty Acid Esters as Used i Cosmetics Status: Draft eport for Pael eview elease Date: March 7, 2016 Pael Meetig Date: March 31-April 1, 2016 The 2016 Cosmetic Igrediet eview Expert Pael members are: Chairma, Wilma F. Bergfeld, M.D., F.A.C.P.; Doald V. Belsito, M.D.; oald A. ill, Ph.D.; Curtis D. Klaasse, Ph.D.; Daiel C. Liebler, Ph.D.; James G. Marks, Jr., M.D., oald C. Shak, Ph.D.; Thomas J. Slaga, Ph.D.; ad Paul W. Syder, D.V.M., Ph.D. The CI Director is Lillia J. Gill, D.P.A. This safety assessmet was prepared by Moice M. Fiume, Assistat Director/Seior Scietific Aalyst/Writer ad Bart eldreth, Ph.D., Chemist. Cosmetic Igrediet eview 1620 L Street, NW, Suite 1200 Washigto, DC ph fax cirifo@cir-safety.org

24 Distributed for Commet ly -- Do Not Cite or Quote INTDUCTIN This is a safety assessmet of the polyglyceryl fatty acid esters as used i cosmetic formulatios. Each of the esters i this group is a polyether comprisig 2 to 20 glyceryl residues, ed-capped by esterificatio with simple carboxylic acids, such as fatty acids. The 275 igrediets icluded i this report are listed alphabetically i Table 1. Table 2 ad Table 3 preset these igrediets based iitially by icreasig polyglyceryl chai legth ad secod by icreasig alkyl chai legth; however, whe there is a mixture of fatty acid costituets, those igrediets are preseted by chai legth for the polyglyceryl moiety ad alphabetically based o the fatty acid compoet. Test data are preseted based o icreasig chai legth (i.e., the order provided i Table 2 ad Table 3). Accordig to the Iteratioal Cosmetic Igrediet Dictioary ad adbook, most of these igrediets are reported to fuctio i cosmetics as ski-coditioig agets ad/or surfactats 1 (Table 3). Additioal fuctios have also bee reported. I 2011, the Cosmetic Igrediet eview (CI) Expert Pael (Pael) published a safety assessmet of a family of igrediets that icluded Polyglyceryl-20 ctaisooaoate; the Pael cocluded that all of the igrediets amed i that report are safe i the preset practices of use ad cocetratio idetified i that assessmet. 2 Because Polyglyceryl-20 ctaisooaoate is a polyglyceryl fatty acid ester ad is structurally related to the igrediets i this report, it is beig icluded i this safety assessmet. The Pael has recetly reviewed the safety of mooglyceryl mooesters, ad cocluded that the mooglyceryl mooesters are safe i cosmetics i the preset practices of use ad cocetratio described i that safety assessmet. 3 Mooglyceryl mooesters ad the polyglyceryl fatty acid esters both cosist of the same startig materials, ad they have the same potetial metabolites. The differece betwee these two families of igrediets is that mooglyceryl mooesters are structurally costituted of the esterificatio products of oly oe equivalet of glyceri ad oe equivalet of a carboxylic acid, as opposed to the varyig umber of equivalets of glyceri ad fatty acids i the polyglyceryl esters. The Pael has previously reviewed the safety of igrediets that represet some of the startig materials of the polyglyceryl fatty acid esters that may persist as residual impurities i the polyglyceryl esters products, or may represet potetial metabolites (e.g., from the actio of esterases i the ski), such as glyceri ad free fatty acids. A list of relevat igrediets that have bee reviewed ad the associated coclusios, is provided i Table 4. (The full reports ca be foud o the CI website: ther igrediets, such as dipropylee glycol ad polypropylee glycols (PPGs), have also bee reviewed ad are also icluded i Table 4 because they have similar properties ad fuctios. Much of the toxicity data icluded i this safety assessmet was foud o the Europea Chemicals Agecy (ECA) website. 4 The ECA website provides summaries of iformatio geerated by idustry, ad it is the summary data that are reported i this safety assessmet whe ECA is cited. Also, whe deemed appropriate, read-across data from ECA are icluded i this report. I some cases i the ECA dossier, such as i 1,2,3-propaetriol, homopolymer, diisooctadecaoate, the umber of polyglyceryl chais is ot defied. Because the umber of polyglyceryl chais is ot defied, ad it therefore is uclear what specific igrediet is beig studied, the data are preseted as potetial read-across data. Several studies that are summarized i this safety assessmet examied the toxicity of a polyglyceryl ester. The exact compositio of the test material was ot idetified i may of the studies ad, geerally, very few details were provided. owever, this iformatio is icluded i this safety assessmet for completeess. CEMISTY Defiitio ad Structure The igrediets i this report are each structurally costituted of the esterificatio products of polyglyceri chais ad fatty acids. These igrediets vary i the umber of equivalets of glyceri ad fatty acids, ad the legth of those fatty acids (Figures 1 ad 2). Figure 1. Geeric structure of polyglyceryl esters, wherei represets hydroge or the residue of certai fatty acids, ad varies from 2 to 20 C 3

25 Distributed for Commet ly -- Do Not Cite or Quote Figure 2. Polyglyceryl-2 caprate (wherei, i the geeral structure i Figure 1, is hydroge i 3 istaces ad caprate i 1 istace; ad is 2) The polymerizatio process used to produce polyglycerol yields a distributio of differet oligomers that have a primarily liear structure. 5 I additio to the liear cofiguratio, a sigificat part of the polyglycerol is of the brached types, e.g., origiatig from 1,2- ad 2,2--ether likages. Polyglyceryl esters of fatty acids have a hydrophilic polyglycerol group that cosists of a fiite umber of hydroxyethers of glycerol ad a hydrophobic fatty acid chai withi the same compoud. 6 These igrediets are o-ioic compouds, ad a rage of polarities is possible because of the variatio of the degree of polymerizatio ad umber of fatty acids per headgroup. Physical ad Chemical Properties The physical properties ad appearace of polyglyceryl esters of fatty acids maily depeds o their molecular structure. Typically, the physical form of those with a higher degree of polymerizatio ad shorter or usaturated fatty acid chais rages from viscous liquids to plastic pastes, ad the polyglyceryl esters with a lower degree of polymerizatio ad loger, saturated fatty acid chais are geerally powders, flakes or small beads. 6 The color of the esters is depedet o the source of the fatty acids, but the polyglycerol will cotribute to the color. 5 The solubility of polyglyceryl esters i orgaic solvets depeds o the ature of the solvet ad the polarity of the ester but, geerally, the esters will show best solubility i protic ad polar aprotic solvets, such as lower alcohols ad dimethyl sulfoxide (DMS). Polyglyceryl esters of fatty acids are polar or amphiphilic lipids, ad the amphiphilic properties i water exhibit mesomorphic activities formig lyotropic liquid crystals. 6 The polyglyceryl ester as a polar emulsifier will form aggregated bodies, such as micelles, at low cocetratios i water. Polyglyceryl esters of fatty acids become ustable with water ad high temperatures, ad the istability is ehaced i the presece of alkalie substaces. The presece of a alkali or acid results i the partial hydrolysis of fatty acids ad the formatio of free polyglycerol. Polyglyceryl esters are comparable to mooglycerides with respect to hydrolysis. I ezymatic systems, lipases will hydrolyze the polyglyceryl ester, as see i the case of other glycerides. 5 The average fatty acid compositios (whe available) are described i Table 5, ad the physical ad chemical properties of may of the igrediets icluded i this safety assessmet are preseted i Table 6. Method of Maufacture The sythesis of polyglyceryl esters of fatty acids is achieved by the polymerizatio of a hydrophilic headgroup, ad the esterificatio of the headgroup with the hydrophobic tails. 6 Polyglycerols are geerally prepared from a alkalie codesatio of glycerol molecules at elevated temperature, with the removal of water. Because oe glycerol molecule possesses 3 reactive sites (1 secodary alcohol (ceter positio) ad 2 primary alcohols (termial positios)), several kids of diglycerol molecules ca be formed. If the polymerizatio proceeds to tri-, tetra-, or higher glycerols, the the umber of possible liear or brached isomers icreases expoetially. Moreover, oce a dimer is formed, cyclic products ca result from itramolecular rig-closure reactios (Figure 3). Figure 3. polymerizatio of glycerol 7 Polyglycerols ca be used as produced, or they may be stripped of excess glycerol ad cyclic glycerols by steam distillatio at reduced pressure. 7 Alteratively, strippig processes have bee developed usig mesoporous ad zeolite catalysts uder milder coditios. ther possible processes for productio of a polyglycerol use reactive petrochemical substaces such as epichlorohydrie (1- chloro-2,3-dihydroxypropae), which is allowed to react with glycerol i a etherificatio process. owever, epichlorohydrie is a hazardous material, ad the purificatio of the polyglycerol complicates the process. 5 Glycidol is also used for the productio of polyglycerol, ad the oxirae group easily reacts with glycerol or epichlorohydrie, depedig o the

26 Distributed for Commet ly -- Do Not Cite or Quote coditios of the reactio ad the type of polyglycerol required. owever, these processes use chemicals that make the process o-competitive i relatio to a glycerol based process. Accordig to the World ealth rgaizatio (W) Food ad Agriculture rgaizatio (FA), polyglyceryl esters of fatty acids (as used i foods) are formed by reactig polymerized glycerols with edible fats, oils (edible fats ad oils are primarily triglycerides), or fatty acids. 8 The degree of polymerizatio varies, ad is specified by a umber (such as tri-) that is related to the average umber of glycerol residues per polyglycerol molecule. Polyglyceryl esters of fatty acids also ca be prepared by direct esterificatio betwee polyolethers ad fatty acids at elevated temperatures (T > 200 C) with the removal of water. 5,6 The esterificatio is ormally carried out uder alkalie coditios ad ca be stopped by simply addig a acid ad lowerig the reactio temperature. To obtai a large amout of moo- ad diesters, the sythesis is geerally carried out with a excess of polyglycerol. Some ureacted polyglycerol ca be removed by simple gravimetric settlig, ad the remaiig fractio by extractio with water combied with salts i a charge-wise separatio process. Alteratively, polyglyceryl esters ca be prepared by a iter-esterificatio (or trasesterificatio) betwee polyglycerols ad triglycerides; this is a reactio carried out at a high temperature ad uder coditios similar to direct esterificatio, but the degree of polymerizatio is ot as high as obtaied with direct esterificatio. Trasesterificatio betwee polyglycerol ad alcohol esters of fatty acids is aother possible method of sythesis; usig this process, methaol is cotiuously removed from the reactor, ad the process icludes a secod step to reduce the remaiig ureacted oxirae oxyge. Compositio ad Impurities Joit FA/W Expert Committee o Food Additives (JECFA) specificatios for polyglyceryl esters of fatty acids used i foods state the polyglycerol moiety shall be composed of ot less tha 70% of di-, tri- ad tetraglycerols ad shall cotai ot more tha 10% of polyglycerols equal to or higher tha heptaglycerol ; that acids other tha fatty acids shall ot be detectable; ad that ot more tha 2 mg/kg lead is detectable. 8 Mior amouts of moo-, di-, ad triglycerides, free glycerol ad polyglycerols, free fatty acids, ad sodium salts of fatty acids may be preset. Trace amouts of ureacted glycerol ad fatty acid soaps ca be foud i polyglyceryl esters of fatty acids. 6 Specificatios, impurities or costituets of some of the igrediets icluded i this report are provided i Table 7. USE Cosmetic The safety of the cosmetic igrediets icluded i this safety assessmet is evaluated based o data received from the U.S. Food ad Drug Admiistratio (FDA) ad the cosmetics idustry o the expected use of these igrediets i cosmetics. Use frequecies of idividual igrediets i cosmetics are collected from maufacturers ad reported by cosmetic product category i FDA s Volutary Cosmetic egistratio Program (VCP) database. Use cocetratio data are submitted by Idustry i respose to surveys, coducted by the Persoal Care Products Coucil (Coucil), of maximum reported use cocetratios by product category. The safety of the cosmetic igrediets icluded i this assessmet is evaluated o the basis of the expected use i cosmetics. i accordace with data received from the U.S. Food ad Drug Admiistratio (FDA) ad the cosmetics idustry. The data received from the FDA are collected from maufacturers o the use of idividual igrediets i cosmetics, by product category. Data from the cosmetic idustry were submitted i respose to surveys of maximum use cocetratios, by product category, coducted by the Persoal Care Products Coucil (Coucil). Based o 2015 VCP data ad the results of the Coucil surveys, 75 of the 275 igrediets icluded i this report are reported to be i use. Accordig to 2015 VCP registratio data, Polyglyceryl-3 Diisostearate has the most reported uses of the igrediets icluded i this report; of the 356 reported uses, 350 are i leave-o formulatios, 260 of which are i lipsticks 9 (Table 8). Polyglyceryl-4 Isostearate has the secod highest umber of reported use; of the 269 uses, all but oe are i leaveo products. The results of the cocetratio of use surveys coducted by the Coucil idicate Polyglyceryl-2 Triisostearate ad Polyglyceryl-3 Diisostearate have the highest cocetratio of use i a leave-o formulatio; these igrediets are used at 40% ad 39%, respectively (Table 8). Additioally, supplier-recommeded use cocetratios are provided; most of the recommeded use levels are 10% (Table 9). Use cocetratios were reported for several igrediets that were ot reported as used i the VCP; it should be presumed there is at least oe use i every category for which a cocetratio is reported. Additioally, several igrediets have uses reported i the VCP, but cocetratio of use data were ot received. The 200 igrediets with o reported uses i both the VCP ad idustry survey are listed i Table 10. May of these polyglyceryl fatty acid esters are used i products applied to the eye area, products that ca result i icidetal igestio, or products that come ito cotact with mucous membraes. The highest reported cocetratios of use for these types of exposures are 24.1% Polyglyceryl-4 Isostearate i other eye make-up preparatios ad 40% Polyglyceryl-2 Triisostearate i lipstick formulatios (resultig i icidetal igestio ad mucous membrae exposure). 11 A few of the polygly-

27 Distributed for Commet ly -- Do Not Cite or Quote ceryl fatty acid esters are reported to be used i baby products; Polyglyceryl-3 Diisostearate has the highest reported use i a baby product, i.e., 2% i baby lotios, oils, ad creams. Additioally, some of the polyglyceryl fatty acid esters are used i cosmetic sprays ad could possibly be ihaled; for example, Polyglyceryl-3 Distearate is reported to be used at 3% spray body ad had creams. I practice, 95% to 99% of the droplets/particles released from cosmetic sprays have aerodyamic equivalet diameters >10 µm, with propellat sprays yieldig a greater fractio of droplets/particles <10 µm compared with pump sprays. 15,16 Therefore, most droplets/particles icidetally ihaled from cosmetic sprays would be deposited i the asopharygeal ad thoracic regios of the respiratory tract ad would ot be respirable (i.e., they would ot eter the lugs) to ay appreciable amout. 17,18 All of the polyglyceryl fatty acids amed i this report are listed i the Europea Uio ivetory of cosmetic igrediets, ad oe of the listed igrediets are restricted from use i ay way uder the rules goverig cosmetic products i the Europea Uio. 19 I Australia, accordig to a Natioal Idustrial Chemicals Notificatio ad Assessmet Scheme (NICNAS), Polyglyceryl-10 Laurate (~60% pure, with ~40% polyglyceri-10 ad ~2% sodium laurate) is ot cosidered to pose a ureasoable risk to public health whe used i the proposed maer (i.e., 3% i ski lotios), ad caot be classified accordig to the Globally armoised System for the Classificatio ad Labellig of Chemicals or the Approved Criteria for Classifyig azardous Substaces. 20 No-Cosmetic Polyglyceryl esters of fatty acids, up to ad icludig the decaglycerol esters, are permitted as multipurpose direct food additives whe (1) they are prepared from cor oil, cottoseed oil, lard, palm oil from fruit, peaut oil, safflower oil, sesame oil, soybea oil, ad tallow ad the fatty acids derived from these substaces (hydrogeated ad o-hydrogeated) ad/or oleic acid derived from tall oil fatty acids; (2) they are used as emulsifiers i food, i amouts ot greater tha that required to produce the iteded physical or techical effect; (3) polyglyceryl esters of a mixture of stearic, oleic, ad cocout fatty acids are used as a cloud ihibitor i vegetable ad salad oils whe use is ot precluded by stadards of idetity, ad oleic acid derived from tall oil fatty acids may be used as a substitute for, or together with, the oleic acid; ad (4) polyglyceryl esters of butter oil fatty acids are used as emulsifiers i combiatio with other approved emulsifiers i dry, whipped toppig base, whe used at a level ot i excess of the amout required to perform their emulsifyig effect. [21CF ] JECFA established a acceptable daily itake (ADI) of 0-25 mg/kg bw for polyglyceryl esters of fatty acids havig a average chai legth of up to 3 glycerol uits, 21 ad a ADI of mg/kg bw for polyglyceryl esters of iteresterified ricioleic acid. 22 I the EU, the esters are listed as food additives at cocetratios betwee 5000 ad 10,000 mg/kg i certai foods, ad up to 7% free glycerol/polyglycerol is allowed (i.e., 700 mg/kg). 23 Polyglyceryl-10 Caprylate/Caprate 24 ad Polyglyceryl- 10 leate 25 are polysorbate replacers, dispersig agets, ad emulsifiers foods. Polyglyceryl-3 Dioleate is used i huma pharmaceutical products ad i veteriary products. 26 It is reported to be suitable for hard ad soft gelati capsules, adsorptio oto eutral carrier powders for use i tablets, capsule fillig ad sachets, ad use i topical oitmets, microemulsios ad emulsios. Polyglyceryl-10 leate is used as a iteral lubricat for polyviyl chloride (PVC) sheet ad film ad as a ati-fog aget i plasticized PVC film formulatios. 25 TXICKINETICS Absorptio, Distributio, Metabolism, ad Excretio (ADME) ral Metabolic studies of polyglyceryl esters idicated that these esters are hydrolyzed i the gastroitestial (GI) tract, ad utilizatio ad digestibility studies supported the assumptio that the fatty acid moiety is metabolized i the ormal maer. 27 Aalytical studies have produced o evidece of accumulatio of the polyglycerol moiety i body tissues. Albio Wistar rats were fed a diet cotaiig 5 or 10% polyglyceryl ester; the exact compositio of the ester was ot provided, but it was stated that the ester was mostly prepared with stearic ad oleic acids. 28 Cotrol aimals were give utreated feed. The umber of aimals per group ad duratio of dosig also was ot specified, however some aimals were fed the test diet for up to 14 mos, ad some were maitaied through 3 geeratios. Feed cosumptio was determied for 2 males ad 2 females per group, ad feces were collected for these aimals for 24days. Fecal lipids were icreased i the test groups whe compared to the cotrols; however, the researchers stated that at least 95-98% of the polyglyceryl esters were digested. Similarly, groups of Wistar rats were fed a diet cotaiig 5% polyglyceryl ester prepared with oleic acid or with liseed oil, ad feed cosumptio was measured ad feces collected for 2 males ad 2 females per group for 24 days. 28 The polyglyceryl esters were almost completely utilized. Groups of 8 male Sherma rats were fed a restricted diet cosistig of 1 g of a polyglyceryl ester i 5 g basic diet/day for 3 wks, followed by 8 wks feedig, ad libitum, of a diet cotaiig 8% of the test material. 29 The esters used i the study raged i size from 2 to 30 glyceryl radicals, with hydrogeated cottoseed oil or peaut oil. Fecal fat excretio, calculated as total lipid extract, absorptio, ad digestibility values, were determied durig the restricted ad ad libitum feedig periods. The

28 Distributed for Commet ly -- Do Not Cite or Quote fecal lipids from rats fed the polyglyceryl hydrogeated cottoseed oil esters were higher i palmitic, stearic, ad oleic acids, ad lower i lioleic acid, tha those the fed the polyglyceryl peaut oil esters. Gas-liquid chromatography (GLC) aalysis of the fatty acids of the extracted lipids from the epididymal fat pads determied that oly triglycerides were preset ad o appreciable amouts of polyglycerols were deposited. A study was coducted i which rats were fed a polyglyceryl ester with a high meltig poit for 8 mos. 30 No residues were detected i depot fat, or i fat of muscle, liver, kidey or splee. (Details were ot provided.) Polyglyceryl leates ad Decaoleate The metabolism of Polyglyceryl-3 leate, Polyglyceryl-10 leate, ad Polyglyceryl-10 Decaoleate was ivestigated i male Sprague-Dawley rats. 31 Groups of 4 rats were dosed with 1% Polyglyceryl-3 [ 14 C]leate, Polyglyceryl-10 [ 14 C]leate, [ 14 C]Polyglyceryl-10 leate, Polyglyceryl-10 [ 14 C]Decaoleate, ad [ 14 C]Polyglyceryl-10 Decaoleate by stomach tube i a liquid diet; the diet cotaied 7-14 µci of 14 C. The study also icluded 2 polyglyceryl esters that are ot cosmetic igrediets, but are similar to igrediets reviewed i this report: triglycerol [ 14 C]tetraoleate ad polyglyceri-10 [ 14 C]mooeicosaoate. Catabolism studies were coducted by admiisterig the test diet, collectig expired C 2, feces, ad urie with the use of metabolism chambers, ad collectig GI tract cotets ad examiig the carcass of each aimal after 51 h. I additioal groups of 4 aimals, simultaeous catabolism-absorptio studies were coducted by isertig a thoracic duct caula i each aimal, dosig the aimals, ad the usig a metabolism chamber for the collectio of lymph, respiratory C 2, feces, ad urie (each as a sigle fractio) for 51 h. Lipids were extracted from the lymph of aimals dosed with fatty-acid labelled esters to determie whether ay itact polyglyceryl esters were preset. The metabolism of the esters was also compared to glycerol-1,3-14 C, [ 14 C]polyglyceri-3, ad [ 14 C]polyglyceri-10. The dispositio of radioactivity followig admiistratio of each compoud is preseted i Table 11. I the catabolism studies, total recovery of the radioactivity raged from 88-98% of the dose. The distributio of the absorbed [ 14 C]Polyglyceryl- 10 leate ad [ 14 C]Polyglyceryl-10 Decaoleate was cosiderably differet from that of glycerol. The absorbed polyglyceryls were excreted primarily i the urie ( %) with less tha 4% of the 14 C appearig i the respiratory C 2 ad less tha 5.5% i the carcass; ~ % was foud i the GI cotets. ly small amouts of radioactivity from the [ 14 C]oleic acid moiety were recovered i feces (~ %) ad GI cotet (~ %), ad the fatty acid appeared to be equally wellabsorbed as the polyceryl-3 ad the polyglyceryl-10 ester. adioactivity from labeled oleic acid moieties of the esters appeared i expired C 2 at close to the same rates as that from glycerol; however, recovery of labeled polyglyceri-3 ad polyglyceri-10 i expired C 2 was less tha 4% of the dose, with upolymerized glycerol accoutig for most of what was recovered. adioactivity from the eicosaoic acid-labeled ester was excreted i C 2 at a lower rate (55.5%) tha that for the oleic acid-labeled compouds. I the catabolism-absorptio studies, % of the radioactivity was recovered. No more tha 5% of the glycerol-labeled esters were absorbed via the lymphatic system; however, ~ % of the radioactivity from the oleic acid-labeled polyglyceryl esters was recovered i the lymph, ad ~54% was recovered i the lymph of aimals give the eicosaoate-labeled polyglyceryl ester. Lipids from the oleate- (ad eicosoaoate-) labeled compouds cotaied 97-99% of the total lymph radioactivity. I vitro hydrolysis studies cofirmed that the oleic acid ester bod i the polyglyceryl-3 ad polyglyceryl-10 esters was readily cleaved. Additioally, it was show that the eicosaoate bod was cleaved more slowly tha the oleate bod. The researchers cocluded that the polyglycerols were ot catabolized, the ether likages are iert to ormal ezymatic hydrolysis, ad the polyglycerols were absorbed ad rapidly excreted i the urie without beig catabolized. Groups of 10 male ad 10 female Sprague-Dawley rats were fed a diet cotaiig 2.5, 5.0, or 10.0% Polyglyceryl-10 Decaoleate for 90 days, ad the cotrol group was fed a diet cotaiig soybea oil as the dietary fat. 32 The percetage of dietary fatty acids absorbed decreased as the levels of Polyglyceryl-10 Decaoleate i the diet icreased. Fat absorptio by males ad females of the 5 ad 10% test groups was statistically sigificatly less tha cotrols at wks 4 ad 10, ad was statistically sigificatly decreased i females of the 2.5% group at wk 4 ad males of the 2.5% group at wk 10. GLC aalysis revealed excretio of oleic acid icreased i a dose-related maer, idicatig that the absorptio of dietary Polyglyceryl-10 Decaoleate was ot complete. I Vitro Polyglyceryl-2 Diisostearate The metabolism of Polyglyceryl-2 Diisostearate was evaluated usig a lipase assay; olive oil was used as a referece substace. 33 Both Polyglyceryl- Diisostearate ad olive oil icreased the fatty acid cocetratio i all reactio vials i a time depedet maer, ad the speed of fatty acid formatio was comparable for both substrates. The i vitro experimetal results support the hypothesis that accumulatio of Polyglyceryl-2 Diisostearate i the gut is ulikely.

29 Distributed for Commet ly -- Do Not Cite or Quote Peetratio Ehacemet Polyglyceryl-3 Diisostearate Polyglyceryl-3 Diisostearate was ot a peetratio ehacer i a study that evaluated the ski peetratio ehacig effects of several excipiets o the hydrophilic drug 5-fluorouracil. 34 The ability to ehace ski peetratio was determied i vitro by measurig ski permeability coefficiets for huma abdomial ski samples. Polyglyceryl-3 Dioleate Polyglyceryl-3 Dioleate is reported to be a water-i-oil surfactat/solubilizer associated with ehaced drug peetratio. 26 Polyglyceryl-4 Laurate ad Polyglyceryl-4 leate The effect of 2 microemulsios o the rate ad extet of release ad peetratio of ceramide AP was evaluated usig a i vitro, multi-layer, membrae model with 4 layers of circular 40-mm membrae films arraged oe over the other. 35 e test microemulsio, a o/w emulsio, cotaied 15% Polyglyceryl-4 Laurate, 15% Polyglyceryl-4 leate, ad 60% water-1,2 petaediol (1:9); the other, a w/o emulsio, cotaied 30% Polyglyceryl-4 Laurate, 15% isopropyl palmitate/lioleic acid (5:2), ad 55% water-1,2 petaediol ( ). Both test formulatios cotaied 0.4% ceramide AP. A o-ioic hydrophilic cream cotaiig 0.5% ceramide AP was used as a referece formulatio. Each test substace, i a amout that cotaied 50 µg ceramide AP, was spread evely over a 4 cm 2 area. The formulatio was left i place for mi; the uabsorbed test material was the removed ad the ceramide was extracted from the membraes. Whe compared to the referece cream, the microemulsios icreased the rate ad extet of peetratio of ceramide AP. Withi 15 mi, a higher percetage of ceramide AP was released from the microemulsios ad peetrated ito the deeper membrae layers; ceramide AP was ot detected i the 3 rd ad 4 th layers whe the referece cream was used. Also, the amout that peetrated ito each layer at each time poit was greater with the microemulsios tha with the cream. The total percet ceramide AP released ad peetrated was 93.4% with the microemulsio cotaiig 15% Polyglyceryl-4 Laurate ad 15% Polyglyceryl-4 leate, 84.2% for the secod test formulatio, ad 73.3% with the referece formulatio. The effect of similar microemulsios ad microemulsio gels o the permeatio of ceramide NP was evaluated i huma thigh ski samples usig Fraz diffusio cells. 36 Several microemulsios were evaluated; the formulatios were composed of 30 or 35% Polyglyceryl-4 Laurate/Polyglyceryl-4 leate (1:1), 10-15% isopropyl palmitate/lioleic acid (9:12), 50-60% water/1,2 petaediol (1.5:8.5), 0.2% ceramide AP, ad 0.1% deuterated ceramide NP. The gels were prepared by dispersig 2.5% Carbopol 940 ito the microemulsio. Some of the formulatios were o/w, ad some were bicotiuous. A hydrophilic cream cotaiig 0.2% deuterated ceramide NP was used as a referece formulatio. Twety mg of each formulatio was applied to the ski surface ( cm 2 ) ad allowed to permeate for 300 mi. After 300 mi, the ski surface was wiped ad the stratum coreum layer was removed with 10 tape strips over a cm 2 area. Subsequetly, 3 ski puches were take ad the epidermal layer was removed. Permeatio was deeper from the microemulsios, as compared to the cream ad the microemulsio gels; additioally, peetratio was deeper with the o/w formulatios compared to the bicotiuous formulatios. Deuterated ceramide NP i the cream did ot permeate ito the deeper layers of the stratum coreum ad other ski layers. Permeatio from the gel was shallow due to its high viscosity. Polyglyceryl-10 Trioleate The effect of Polyglyceryl-10 Trioleate o the permeatio of teoxicam (a o-steroidal ati-iflammatory drug) i a propylee glycol solutio was examied i vitro usig dorsal ski from male artley strai guiea pigs. 37 The test solutio was prepared by suspedig 0.3 g teoxicam i a mixed solutio of 3.0 g propylee glycol ad 1.5 g Polyglyceryl-10 Trioleate, ad the suspesio was adjusted to a p of 6.0. Usig a Fraz-type diffusio chamber, 1 g of the resultig suspesio, which cotaied 1% teoxicam, 10% propylee glycol, ad 5% Polyglyceryl-10 Trioleate, was applied to the door ski, ad 1.0 ml of the receptor solutio was sampled every 3 h for 48 h. The flux of teoxicam was statistically sigificatly ehaced by the iclusio of Polyglyceryl-10 Trioleate, from 8.11 x 10-5 µg/s cm 2 to µg/s cm 2. TXICLGICAL STUDIES Acute Toxicity Acute toxicity studies are summarized i Table ,33,38-48 I a acute dermal toxicity study i rats, the LD 50 of 1,2,3-propaetriol, homopolymer, diisooctadecaoate was>5 g/kg. Low toxicity was reported i acute oral studies. I rats, the LD 50 >2 g/kg for Polyglyceryl-3 Caprate, Polyglyceryl-3 Caprylate, Polyglyceryl-4 Caprate, Diisostearoyl Polyglyceryl-3 dimer Dilioleate, ad the LD 50 was >5 g/kg for Polyglyceryl-3 Isostearate, Polyglyceryl-3leate, Polyglyceryl-2 Diisostearate ad Polyglyceryl-3 Diisostearate.

30 Distributed for Commet ly -- Do Not Cite or Quote epeated Dose Toxicity Aimal ral Polyglyceryl Esters - geeral I rats, repeated oral dosig with 10 g/kg bw polyglyceryl ester daily over 5 days caused o deaths. 27 (No details were provided.) Groups of 25 male ad 25 female mice were fed a diet with 5% polyglyceryl ester for 80 wks. 27 No adverse effects o body weight, feed cosumptio, hematology values, or survival rate were oted. Carcass fat of the test group showed o polyglycerol residues. The levels of free fatty acids, usapoifiable material, ad the fatty acid compositio of carcass fat were the same for the test group compared to a cotrol group fed 5% groud ut oil i the diet. The oly differeces oted i orga weights were for the liver ad kideys of female mice, which were sigificatly higher. Microscopic examiatio of all major orgas showed othig remarkable. I the ADME study described previously, i which Wistar rats were fed a diet cotaiig 5 or 10% polyglyceryl ester (prepared mostly with stearic ad oleic acid), o abormalities were observed upo microscopic examiatio of tissues (details ot provided). 28 The feedig of a restricted diet cosistig of 1 g of a polyglyceryl ester i 5 g basic diet/day for 3 wks to Sherma rats, followed by 8 wks feedig, ad libitum, of a diet cotaiig 8% of the test material (8 males/group; study described i the ADME sectio) did ot result i ay microscopic abormalities i the liver, kideys, or ileum. 29 Polyglyceryl Stearate Two groups of 4 male albio rats were admiistered a suspesio of 1 g/kg bw/day of polyglyceryl stearate (glyceryl chai legth ot stated) i a aqueous solutio of 0.5% carboxymethylcellulose (CMC) ad 0.1% Twee 80 for 10 wks; oe group was fed a basic diet, ad the other a diet supplemeted with 5% hydrogeated fat. 49 Two utreated cotrol groups, oe fed a basal diet ad oe the fat-supplemeted diet, were used. Polyglyceryl stearate was ot toxic, ad it did ot have a effect o red blood cell cout, white blood cell cout, or hemoglobi values. Polyglyceryl-2 Diisostearate I a dietary study, 5 male ad 5 female rats per group were give feed cotaiig 0, 0.012, 0.12, or 1.2% Polyglyceryl-2 Diisostearate (for a targeted dose of 0, 10, 100, or 1000 mg/kg/day, respectively) for 28 days, ad a cotrol group was give utreated feed. 33 There were o mortalities, cliical sigs of toxicity, effects o body weight, cliical pathology, or gross or histopathology alteratios that were cosidered related to the dietary admiistratio of the test substace ad/or cosidered to be of toxicological sigificace. The o observed adverse effect level (NAEL) was 845 mg/kg/day i males ad 922 mg/kg/day i females, correspodig to the highest dietary cocetratio tested. Polyglyceryl-10 Decaoleate Groups of 10 male ad 10 female Sprague-Dawley rats were fed a diet cotaiig 2.5, 5.0, or 10.0% Polyglyceryl-10 Decaoleate for 90 days, ad the cotrol group was fed a diet cotaiig soybea oil as the dietary fat. 32 Urie was collected from each group durig wks 3 ad 9, total fatty acid absorptio was determied i feces collected durig wks 4 ad 10, ad hematological studies were coducted durig wks 5 ad 11, ad at study termiatio. No test article-related sigs of toxicity were observed. Gross ad microscopic examiatio of the testes ad ovaries ad other orgas did ot reveal ay sigs of toxicity or microscopic lesios, ad relative ad absolute orga weights were uremarkable. uma ral Polyglyceryl Esters - geeral For 3 wks, 37 subjects were fed 2-20 g/day polyglyceryl ester i their diet. 27 No abormalities were detected i the hematology or cliical chemistry values or uriary or fecal parameters that were examied. EPDUCTIVE AND DEVELPMENTAL TXICITY ral Polyglyceryl Esters - geeral A test group of 22 rats was fed a diet cotaiig 1.5% polyglycerol for 3 geeratios. 27 A group of 28 rats was used as a cotrol. The aimals were kept for over 1 year without sigificat variatio i fertility or reproductive performace. Gross ad microscopic examiatio of the third geeratio revealed o cosistet abormality attributable to the test substace. No details were provided.

31 Distributed for Commet ly -- Do Not Cite or Quote Polyglyceryl-3 Diisostearate A combied repeated dose oral toxicity study with a reproductio/developmetal toxicity screeig test (ECD Guidelie 422) was coducted i Wistar rats. 38 The aimals were dosed oce daily by gavage with 0, 100, 300, or 1000 mg/kg bw/day 1,2,3-propaetriol, homopolymer, diisooctadecaoate ( ot defied; this substace is most likely Polyglyceryl-3 Diisostearate) i cor oil. Iitially, the groups cosisted of 12 males ad 12 females. owever, because a disturbace of the light/dark cycle was believed to cause a reductio i matig rate of the females of the first delivery, additioal male ad female rats were added i a secod delivery for breedig to meet guidelie requiremets for the umber of gravid females per group. The additioal aimals were used i the etire study as the aimals from the first delivery, with the exceptio that the males of the secod delivery were ecropsied o day 24 after matig, ot o day 16 of matig. Therefore, Polyglyceryl-3 Diisostearate was admiistered to male rats for up to 28 days (first delivery) ad up to 41 days (secod delivery) ad to female rats for 14 days prior to matig, through the matig ad gestatio periods, ad util the F 1 geeratio reached day 4 post-partum. Because a impact caused by the light/dark cycle disturbace could ot be excluded (i.e., a prologed duratio of gestatio ad a icreased post-implatatio loss at the high dose), the study was repeated with a third delivery with cotrol ad highdose groups uder proper light coditios. The test article was admiistered to12 male rats/group for 33 days ad to 12 female rats/group for 14 days prior to matig, through matig ad gestatio, ad util day 4 post-partum. Five males ad 5 females/group killed at the ed of the study were selected for hematology ad cliical chemistry examiatios, ad some additioal orgas were weighed. The NEL ad NAEL for systemic effects were 300 mg/kg bw/day ad 1000 mg/kg bw/day 1,2,3-propaetriol, homopolymer, diisooctadecaoate, respectively, i both males ad females. No adverse effects o body weights ad body weight gais, feed cosumptio, hematology, cliical chemistry, eurobehavior, or gross or microscopic lesios were observed. Statistically sigificat icreases i absolute ad relative liver ad kidey weights i males ad females of the 1000 mg/kg bw/day were ot cosidered to be adverse effects because there was o evidece for a impairmet of orga fuctio by cliical pathology ad histopathology. Additioally, icreases i the absolute ad relative heart weights i high-dose females were without histopathological correlatio ad cosidered to be icidetal. GENTXICITY Geotoxicity studies are summarized i Table ,33,38-44,46,50-52 Geerally, egative results were obtaied i geotoxicity tests. Polyglyceryl-2 leate, Polyglyceryl-2 Diisostearate, ad 1,2,3-propaetriol, homopolymer, diisooctadecaoate were ot geotoxic i the Ames test, mammalia cell gee mutatio assay, or chromosomal aberratio assay, with or without metabolic activatio. Polyglyceryl-3 Caprate, Polyglyceryl- Caprylate, Polyglyceryl-3 Laurate, Polyglyceryl-3 Isostearate, Polyglyceryl-4Caprate, Polyglyceryl-4 Isostearate, Polyglyceryl-4 Laurate/Succiate, ad Diisostearoyl Polyglyceryl-3 Dimer Dilioleate were egative i the Ames test. Polyglyceryl-6 Caprylate/CapratePolyglyceryl-10 Laurate (~60% pure) gave equivocal results i the absece ad positive results i the presece of metabolic activatio whe tested at cocetratios up to 125 ad 2250 µg/ml, respectively, i a chromosomal aberratio assay usig Chiese hamster V79 cells, but was ot clastogeic i a chromosomal aberratio assay i huma peripheral lymphocytes, with or without activatio. Accordig to the Europea Food Safety Authority (EFSA) Pael, the impurities of polyglyceryl fatty acid esters, i.e. free fatty acids ad their esters, have o structural alerts for geotoxicity. 23 CACINGENICITY ral I a 2-yr study, 28 male ad 28 female rats were fed 5% polyglyceryl ester i the diet. 27 No adverse effects o body weight, feed cosumptio, hematology values, or survival rate were oted. Liver fuctio tests ad real fuctio tests performed at 59 ad 104 wks of the study were comparable betwee the test group ad a cotrol group fed 5% groud ut oil. The carcass fat cotaied o polyglycerol, ad the levels of free fatty acid, usapoifiable residue ad fatty acid compositio of carcass fat were ot differet from the cotrols. rga weights, tumor icidece ad tumor distributio ware similar i cotrol ad test groups. A complete histological examiatio of major orgas showed othig remarkable. IITATIN AND SENSITIZATIN Ski Irritatio/Sesitizatio Dermal irritatio ad sesitizatio studies are summarized i Table ,38-45,45,46,50,53-62 Apricot Kerel il Polyglyceryl-4 Esters ad Palm il Polyglyceryl-4 Esters were classified as o-irritat i the SkiEthic TM irritatio test, ad Polyglyceryl-4 Laurate/Sebacate, Polyglyceryl-4 Laurate/Succiate, ad Polyglyceryl-6 Caprylate/Caprate were cosidered to be o-irritat i the EpiSki TM model for ski irritatio.

32 Distributed for Commet ly -- Do Not Cite or Quote I rabbits, Polyglyceryl-3 Caprate, a polyglyceryl moo/diester of capric acid (read-across for Polyglyceryl-3 Caprylate), Polyglyceryl-4 Caprate, Polyglyceryl-3 Diisostearate ad 1,2,3-propaetriol, homopolymer, diisooctadecaoate were ot irritatig to the ski. Polyglyceryl-2 Isostearate was mildly irritatig, Polyglyceryl-2 Diisostearate was slightly irritatig, ad Polyglyceryl-3 Isostearate ad Polyglycyceryl-3 leate were moderate irritats i rabbit ski. Polyglyceryl-3 Caprate, Polyglyceryl-3 Caprylate, Polyglyceryl-3 Isostearate, Polyglyceryl-4 Caprate, Polyglyceryl-4 Isostearate, Polyglyceryl-2 Diisostearate, ad Polyglyceryl-4 Diisostearate/Polyhydroxystearate/Sebacate (read-across for Diisostearoyl Polyglyceryl-3 Dimer Dilioleate) were ot sesitizers i guiea pig studies. Polyglyceryl-3 Diisostearate was ot a sesitizer i guiea pigs i oe sesitizatio study (50% at iductio ad challege; 25% at rechallege), but results were icoclusive i a guiea pig maximizatio test (0.1% or 0.2% at itradermal iductio; 40% at epicutaeous iductio; 10 ad 15% at challege; 8 ad 4% at rechallege). I a cliical study, 7% Polyglyceryl-2 Isostearate elicited slight irritatio. I other studies, 10% Polyglyceryl-10 Myristate, 10% Polyglyceryl-10 Stearate, 20% active 1,2,3-propaetriol, homopolymer, diisooctadecaoate, 50% Polyglyceryl-10 Petaisostearate, a mixture cotaiig 60% Polyglyceryl-10 Eicosaedioate/Tetradecaedioate, ad udiluted Polyglyceryl-2 Sesquiisostearate, Diisostearoyl Polyglyceryl-3 Dimer Dilioleate, ad Polyglyceryl-10 Decaoleate were ot irritats. Polyglyceryl-3 Laurate ad udiluted Triisostearoyl Polyglyceryl-3 Dimer Dilioleate were ot irritats or sesitizers. cular Irritatio cular irritatio studies are summarized i Table ,33,36,38-47,58-60,63-67 Polyglyceryl-3 Laurate, a mixture cotaiig 60% Polyglyceryl-10 Eicosaedioate/Tetradecaedioate, ad Triisostearoyl Polyglyceryl-3 Dimer Dilioleate (10% i cor oil) were classified as o-irritatig usig a Epicular TM tissue model. I the he s egg test chorioallatoic membrae (ET-CAM) assay, microemulsios cotaiig 30% or 40% Polyglyceryl-4 Laurate, Apricot Kerel il Polyglyceryl-4 Esters, Palm il Polyglyceryl-4 Esters, ad Polyglyceryl-2 Dioleate were classified as o-irritat, ad Diisostearoyl Polyglyceryl-3 Dimer Dilioleate produced mior irritatio. Polyglyceryl-4 Laurate/Sebacate, Polyglyceryl-4 Laurate/Succiate, ad Polyglyceryl-6 Caprylate/Caprate were cosidered o-irritat i the SkiEthic TM recostituted huma coreal epithelium model, ad Polyglyceryl-10 Myristate, Polyglyceryl-10 Stearate, ad Polyglyceryl-10 Diisostearate were o-irritatig usig the SIC-eutral red (N) method. Polyglyceryl-3 Caprate, a polyglyceryl moo/diester of capric acid (read-across for Polyglyceryl-3 Caprylate), Polyglyceryl-4 Caprate, Polyglyceryl-2 Diisostearate, Polyglyceryl-2 Dioleate, Polyglyceryl-3 Diisostearate, ad 1,2,3-propaetriol, homopolymer, diisooctadecaoate were ot irritatig to rabbit eyes, ad Polyglyceryl-3 Isostearate ad Polyglyceryl-3 leate were slightly irritatig to rabbit eyes. Polyglyceryl-10 Laurate (~60% pure) was possibly slightly irritatig to the eyes of humas. Case eports A case report described the icidece of recurrig pruritic erythema over a 3-mo period i a 80-yr old female. 68 A 48-h closed patch test with the subject s cosmetics was positive (++). Subsequet testig with the idividual igrediets was positive (+) with 0.5% aqueous (aq.) Polyglyceryl-10 Laurate, ad the irritatio caused by this substace was still preset i this patiet 7 days after exposure. Positive reactios (+) were reported at all cocetratios with additioal testig of % aq. Polyglyceryl-10 Laurate. After 6 mos, patch tests with 0.1-1% Polyglyceryl-10 Laurate (obtaied from several suppliers), as well as to 0.5-1% Polyglyceryl-4 Laurate ad Polyglyceryl-6 Laurate, were positive. No reactios were reported with 0.1-1% aq. Polyglyceryl-10 Myristate, Polyglyceryl-10 Isostearate, Polyglyceryl-10 Stearate, ad Polyglyceryl- 10 leate, or with the cotrol test materials. SUMMAY This assessmet reviews the safety of 275 polyglyceryl fatty acid esters as used i cosmetics. Each of the esters i this group is a polyether comprisig 2 to 20 glyceryl residues, ed-capped by esterificatio with simple carboxylic acids, such as fatty acids. Most of these igrediets are reported to fuctio i cosmetics as ski-coditioig agets ad/or surfactats. Sevety-five of the 275 igrediets icluded i this report are reported to be i use. Polyglyceryl-3 Diisostearate has the most reported uses (356, 260 of which are i lipsticks) of the igrediets icluded i this report, ad Polyglyceryl-4 Isostearate has the secod highest umber of reported uses (269). Polyglyceryl-2 Triisostearate ad Polyglyceryl-3 Diisostearate have the highest cocetratio of use i a leave-o formulatio; these igrediets are used at 40% ad 39%, respectively. May of these polyglyceryl fatty acid esters are used i products applied to the eye area, products that ca result i icidetal igestio, or products that come ito cotact with mucous membraes, ad a few of the polyglyceryl fatty acid esters are reported to be used i baby products. Additioally, some of the polyglyceryl fatty acid esters are used i cosmetic sprays ad could possibly be ihaled. Polyglyceryl esters of fatty acids, up to ad icludig the decaglycerol esters, are permitted as multipurpose direct food additives. JECFA established a ADI of 0-25 mg/kg bw for polyglyceryl esters of fatty acids havig a average chai legth of up to 3 glycerol uits, ad a ADI of mg/kg bw for polyglyceryl esters of iteresterified ricioleic acid. I the EU, the esters are listed as food additives at levels betwee 5000 ad 10,000 mg/kg i certai foods, ad up to 7% free glycerol/polyglycerol is allowed (i.e., 700 mg/kg).

33 Distributed for Commet ly -- Do Not Cite or Quote Polyglyceryl esters are hydrolyzed i the GI tract, ad the fatty acid moiety is metabolized i a ormal maer. Aalytical studies have produced o evidece of accumulatio of the polyglycerol moiety i body tissues. The ability to ehace ski peetratio was examied for several of the polyglyceryl fatty acid esters. Polyglyceryl-3 Dioleate is reported to be a water-i-oil surfactat/solubilizer associated with ehaced drug peetratio. Polyglyceryl-10 Trioleate ehaced the flux of teoxicam i a i vitro study. Microemulsios cotaiig Polyglyceryl-4 Laurate ad Polyglyceryl-4 leate icreased ceramide permeatio ito ski. I a acute dermal toxicity study i rats, the LD 50 of 1,2,3-propaetriol, homopolymer, diisooctadecaoate was>5 g/kg. Low toxicity was reported i acute oral studies. I rats, the LD 50 >2 g/kg for Polyglyceryl-3 Caprate, Polyglyceryl-3 Caprylate, Polyglyceryl-4 Caprate, Diisostearoyl Polyglyceryl-3 dimer Dilioleate, ad the LD 50 was >5 g/kg for Polyglyceryl-3 Isostearate, Polyglyceryl-3leate, Polyglyceryl-2 Diisostearate ad Polyglyceryl-3 Diisostearate. Dietary studies with polyglyceryl ester, polyglyceryl stearate, Polyglyceryl-2 Diisostearate, ad Polyglyceyrl-10 Decaoleate did ot produce ay remarkable effects. No test-article related adverse effects were observed i multi-geeratioal studies with polyglyceryl esters or 1,2,3-propaetriol, homopolymer, diisooctadecaoate. Geerally, egative results were obtaied i geotoxicity tests. Polyglyceryl-2 leate, Polyglyceryl-2 Diisostearate, ad 1,2,3-propaetriol, homopolymer, diisooctadecaoate were ot geotoxic i the Ames test, mammalia cell gee mutatio assay, or chromosomal aberratio assay, with or without metabolic activatio. Polyglyceryl-3 Caprate, Polyglyceryl-3 Caprylate, Polyglyceryl-3 Laurate, Polyglyceryl-3 Isostearate, Polyglyceryl-4Caprate, Polyglyceryl-4 Isostearate, Polyglyceryl-4 Laurate/Succiate, ad Diisostearoyl Polyglyceryl-3 Dimer Dilioleate were egative i the Ames test. Polyglyceryl- 6 Caprylate/CapratePolyglyceryl-10 Laurate (~60% pure) gave equivocal results i the absece ad positive results i the presece of metabolic activatio whe tested at cocetratios up to 125 ad 2250 µg/ml, respectively, i a chromosomal aberratio assay usig Chiese hamster V79 cells, but was ot clastogeic i a chromosomal aberratio assay i huma peripheral lymphocytes, with or without activatio. The impurities of polyglyceryl fatty acid esters, i.e. free fatty acids ad their esters, have o structural alerts for geotoxicity. I a 2-yr dietary study i rats, 5% polyglyceryl ester was ot carciogeic ad did ot produce ay adverse effects. Apricot Kerel il Polyglyceryl-4 Esters ad Palm il Polyglyceryl-4 Esters were classified as o-irritat i the SkiEthic TM irritatio test, ad Polyglyceryl-4 Laurate/Sebacate, Polyglyceryl-4 Laurate/Succiate, ad Polyglyceryl-6 Caprylate/Caprate were cosidered to be o-irritat i the EpiSki TM model for ski irritatio. I rabbits, Polyglyceryl-3 Caprate, a polyglyceryl moo/diester of capric acid (read-across for Polyglyceryl-3 Caprylate), Polyglyceryl-4 Caprate, Polyglyceryl-3 Diisostearate ad 1,2,3-propaetriol, homopolymer, diisooctadecaoate were ot irritatig to the ski. Polyglyceryl-2 Isostearate was mildly irritatig, Polyglyceryl-2 Diisostearate was slightly irritatig, ad Polyglyceryl-3 Isostearate ad Polyglycyceryl-3 leate were moderate irritats i rabbit ski. Polyglyceryl-3 Caprate, Polyglyceryl-3 Caprylate, Polyglyceryl-3 Isostearate, Polyglyceryl-4 Caprate, Polyglyceryl-4 Isostearate, Polyglyceryl-2 Diisostearate, ad Polyglyceryl-4 Diisostearate/Polyhydroxystearate/Sebacate (read-across for Diisostearoyl Polyglyceryl-3 Dimer Dilioleate) were ot sesitizers i guiea pig studies. Polyglyceryl-3 Diisostearate was ot a sesitizer i guiea pigs i oe sesitizatio study (50% at iductio ad challege; 25% at rechallege), but results were icoclusive i a guiea pig maximizatio test (0.1% or 0.2% at itradermal iductio; 40% at epicutaeous iductio; 10 ad 15% at challege; 8 ad 4% at rechallege). I a cliical study, 7% Polyglyceryl-2 Isostearate elicited slight irritatio. I other studies, 10% Polyglyceryl-10 Myristate, 10% Polyglyceryl-10 Stearate, 20% active 1,2,3-propaetriol, homopolymer, diisooctadecaoate, 50% Polyglyceryl-10 Petaisostearate, a mixture cotaiig 60% Polyglyceryl-10 Eicosaedioate/Tetradecaedioate, ad udiluted Polyglyceryl-2 Sesquiisostearate, Diisostearoyl Polyglyceryl-3 Dimer Dilioleate, ad Polyglyceryl-10 Decaoleate were ot irritats. Polyglyceryl-3 Laurate ad udiluted Triisostearoyl Polyglyceryl-3 Dimer Dilioleate were ot irritats or sesitizers. Polyglyceryl-3 Laurate, a mixture cotaiig 60% Polyglyceryl-10 Eicosaedioate/Tetradecaedioate, ad Triisostearoyl Polyglyceryl-3 Dimer Dilioleate (10% i cor oil) were classified as o-irritatig usig a Epicular TM tissue model. I the he s egg test chorioallatoic membrae (ET-CAM) assay, microemulsios cotaiig 30% or 40% Polyglyceryl-4 Laurate, Apricot Kerel il Polyglyceryl-4 Esters, Palm il Polyglyceryl-4 Esters, ad Polyglyceryl-2 Dioleate were classified as o-irritat, ad Diisostearoyl Polyglyceryl-3 Dimer Dilioleate produced mior irritatio. Polyglyceryl-4 Laurate/Sebacate, Polyglyceryl-4 Laurate/Succiate, ad Polyglyceryl-6 Caprylate/Caprate were cosidered o-irritat i the SkiEthic TM recostituted huma coreal epithelium model, ad Polyglyceryl-10 Myristate, Polyglyceryl-10 Stearate, ad Polyglyceryl-10 Diisostearate were o-irritatig usig the SIC-eutral red (N) method. Polyglyceryl-3 Caprate, a polyglyceryl moo/diester of capric acid (read-across for Polyglyceryl-3 Caprylate), Polyglyceryl-4 Caprate, Polyglyceryl-2 Diisostearate, Polyglyceryl-2 Dioleate, Polyglyceryl-3 Diisostearate, ad 1,2,3-propaetriol, homopolymer, diisooctadecaoate were ot irritatig to rabbit eyes, ad Polyglyceryl-3 Isostearate ad Polyglyceryl-3 leate were slightly irritatig to rabbit eyes. Polyglyceryl-10 Laurate (~60% pure) was possibly slightly irritatig to the eyes of humas.

34 Distributed for Commet ly -- Do Not Cite or Quote To be developed. To be determied. DISCUSSIN CNCLUSIN

35 Distributed for Commet ly -- Do Not Cite or Quote TABLES Table 1. Polyglyceryl Fatty Acid Esters preseted alphabetically Acacia Decurres/Jojoba/Suflower Seed Wax Polyglyceryl 3 Esters Adasoia Digitata Seed il Polyglyceryl-6 Esters Almod il/polyglyceryl-10 Esters Apricot Kerel il Polyglyceryl-3 Esters Apricot Kerel il Polyglyceryl-4 Esters Apricot Kerel il Polyglyceryl-5 Esters Apricot Kerel il Polyglyceryl-6 Esters Apricot Kerel il Polyglyceryl-10 Esters Arga il Polyglyceryl-6 Esters Astrocaryum Vulgare il Polyglyceryl-6 Esters Avocado il Polyglyceryl-6 Esters Babassu il Polyglyceryl-4 Esters Babassu il Polyglyceryl-6 Esters Bertholletia Excelsa Seed il Polyglyceryl-6 Esters Borage Seed il Polyglyceryl-4 Esters Borage Seed il Polyglyceryl-6 Esters Cadelilla/Jojoba/ice Bra Polyglyceryl-3 Esters Caprylic/Capric Glycerides Polyglyceryl-10 Esters Carapa Guaiaesis il Polyglyceryl-6 Esters Castor il Polyglyceryl-6 Esters Cocoa Butter Polyglyceryl-6 Esters Cocout il Polyglyceryl-6 Esters Coffee Seed il Polyglyceryl-6 Esters Diisostearoyl Polyglyceryl-3 Dimer Dilioleate Glyceryl/Polyglyceryl-6 Isostearate/Beheate Esters azelut Seed il Polyglyceryl-6 Esters Liseed il Polyglyceryl-4 Esters Macadamia Seed il Polyglyceryl-6 Esters Macadamia Seed il Polyglyceryl-6 Esters Beheate Mauritia Flexuosa Seed il Polyglyceryl-6 Esters live il Polyglyceryl-3 Esters live il Polyglyceryl-4 Esters live il Polyglyceryl-6 Esters Palm Kerel il Polyglyceryl-4 Esters Palm il Polyglyceryl-3 Esters Palm il Polyglyceryl-4 Esters Palm il Polyglyceryl-5 Esters Palm il Polyglyceryl-6 Esters Pariari Curatellifolia il Polyglyceryl-6 Esters Pius Sibirica Seed il Polyglyceryl-6 Esters Polyglyceryl-2 Caprate Polyglyceryl-2 Caprylate Polyglyceryl-2 Diisostearate Polyglyceryl-2 Dioleate Polyglyceryl-2 Distearate Polyglyceryl-2 Isopalmitate Polyglyceryl-2 Isopalmitate/Sebacate Polyglyceryl-2 Isostearate Polyglyceryl-2 Laurate Polyglyceryl-2 Myristate Polyglyceryl-2 leate Polyglyceryl-2 Palmitate Polyglyceryl-2 Sesquicaprylate Polyglyceryl-2 Sesquiisostearate Polyglyceryl-2 Sesquioleate Polyglyceryl-2 Sesquistearate Polyglyceryl-2 Stearate Polyglyceryl-2 Tetrabeheate/ Macadamiate/Sebacate Polyglyceryl-2 Tetraisostearate Polyglyceryl-2 Tetraoleate Polyglyceryl-2 Tetrastearate Polyglyceryl-2 Triisostearate Polyglyceryl-3 Beeswax Polyglyceryl-3 Beheate Polyglyceryl-3 Caprate Polyglyceryl-3 Caprylate Polyglyceryl-3 Cocoate Polyglyceryl-3 Dicaprate Polyglyceryl-3 Dicitrate/Stearate Polyglyceryl-3 Dicocoate Polyglyceryl-3 Di-ydroxystearate Polyglyceryl-3 Diisostearate Polyglyceryl-3 Dioleate Polyglyceryl-3 Distearate Polyglyceryl-3 Isostearate Polyglyceryl-3 Laurate Polyglyceryl-3 Myristate Polyglyceryl-3 leate Polyglyceryl-3 Palmitate Polyglyceryl-3 Petacaprylate/Caprate Polyglyceryl-3 Petaolivate Polyglyceryl-3 Petaricioleate Polyglyceryl-3 ice Braate Polyglyceryl-3 icioleate Polyglyceryl-3 Soyate/Shea Butterate Polyglyceryl-3 Stearate Polyglyceryl-3 Stearate SE Polyglyceryl-3 Triisostearate Polyglyceryl-3 Triolivate Polyglyceryl-4 Almodate/Shea Butterate Polyglyceryl-4 Caprate Polyglyceryl-4 Caprylate Polyglyceryl-4 Caprylate/Caprate Polyglyceryl-4 Cocoate Polyglyceryl-4 Dilaurate Polyglyceryl-4 Distearate Polyglyceryl-4 azelutseedate Polyglyceryl-4 Isostearate Polyglyceryl-4 Isostearate/Laurate Polyglyceryl-4 Laurate Polyglyceryl-4 Laurate/Sebacate Polyglyceryl-4 Laurate/Succiate Polyglyceryl-4 leate Polyglyceryl-4 Petaoleate Polyglyceryl-4 Petapalmitate/Stearate Polyglyceryl-4 Petastearate Polyglyceryl-4 Puicate Polyglyceryl-4 Stearate Polyglyceryl-4 Sweet Almodate Polyglyceryl-4 Tristearate Polyglyceryl-5 Caprate Polyglyceryl-5 Dicaprylate Polyglyceryl-5 Dilaurate Polyglyceryl-5 Dioleate Polyglyceryl-5 exastearate Polyglyceryl-5 Isostearate Polyglyceryl-5 Laurate Polyglyceryl-5 Myristate Polyglyceryl-5 leate Polyglyceryl-5 Petamyristate Polyglyceryl-5 icioleate Polyglyceryl-5 Stearate Polyglyceryl-5 Tribeheate Polyglyceryl-5 Triisostearate Polyglyceryl-5 Trimyristate Polyglyceryl-5 Trioleate Polyglyceryl-5 Tristearate Polyglyceryl-6 Adasoia Digitata Seedate Polyglyceryl-6 Apricot Kerelate Polyglyceryl-6 Arga Kerelate Polyglyceryl-6 Beheate Polyglyceryl-6 Caprate Polyglyceryl-6 Caprylate Polyglyceryl-6 Caprylate/Caprate Polyglyceryl-6 Citrullus Laatus Seedate Polyglyceryl-6 Dicaprate Polyglyceryl-6 Diisostearate Polyglyceryl-6 Dioleate

36 Distributed for Commet ly -- Do Not Cite or Quote Polyglyceryl-6 Dipalmitate Polyglyceryl-6 Distearate Polyglyceryl-6 eptacaprylate Polyglyceryl-6 exaoleate Polyglyceryl-6 exastearate Polyglyceryl-6 Isostearate Polyglyceryl-6 Laurate Polyglyceryl-6 Myristate Polyglyceryl-6 ctacaprylate Polyglyceryl-6 ctastearate Polyglyceryl-6 leate Polyglyceryl-6 Palmitate Polyglyceryl-6 Palmitate/Succiate Polyglyceryl-6 Petacaprylate Polyglyceryl-6 Petaoleate Polyglyceryl-6 Petaricioleate Polyglyceryl-6 Petastearate Polyglyceryl-6 icioleate Polyglyceryl-6 Schiziophyto autaeii Kerelate Polyglyceryl-6 Sclerocarya Birrea Seedate Polyglyceryl-6 Sesquicaprylate Polyglyceryl-6 Sesquiisostearate Polyglyceryl-6 Sesquistearate Polyglyceryl-6 Stearate Polyglyceryl-6 Tetrabeheate Polyglyceryl-6 Tetracaprylate Polyglyceryl-6 Tetraoleate Polyglyceryl-6 Tricaprylate Polyglyceryl-6 Trichilia Emetica Seedate Polyglyceryl-6 Tristearate Polyglyceryl-6 Udecyleate Polyglyceryl-6 Ximeia Americaa Seedate Polyglyceryl-8 C12-20 Acid Ester Polyglyceryl-8 Decabeheate/Caprate Polyglyceryl-8 Decaerucate/Decaisostearate/ Decaricioleate Polyglyceryl-8 leate Polyglyceryl-8 Stearate Polyglyceryl-10 Apricot Kerelate Polyglyceryl-10 Beheate/Eicosadioate Polyglyceryl-10 Caprate Polyglyceryl-10 Caprylate Polyglyceryl-10 Caprylate/Caprate Polyglyceryl-10 Cocoate Polyglyceryl-10 Decaethylhexaoate Polyglyceryl-10 Decahydroxystearate Polyglyceryl-10 Decaisostearate Polyglyceryl-10 Decalioleate Polyglyceryl-10 Decamacadamiate Polyglyceryl-10 Decaoleate Polyglyceryl-10 Decastearate Polyglyceryl-10 Dicocoate Polyglyceryl-10 Didecaoate Polyglyceryl-10 Diisostearate Polyglyceryl-10 Dilaurate Polyglyceryl-10 Dimyristate Polyglyceryl-10 Dioleate Polyglyceryl-10 Dipalmitate Polyglyceryl-10 Distearate Polyglyceryl-10 Dodecabeheate Polyglyceryl-10 Dodecacaprate Polyglyceryl-10 Dodecacaprylate Polyglyceryl-10 Dodeca-Caprylate/ Caprate Polyglyceryl-10 Eicosaedioate/Tetradecaedioate Polyglyceryl-10 epta(beheate/stearate) Polyglyceryl-10 eptahydroxystearate Polyglyceryl-10 eptaoleate Polyglyceryl-10 eptastearate Polyglyceryl-10 exaerucate Polyglyceryl-10 exaisostearate Polyglyceryl-10 exaoleate Polyglyceryl-10 ydroxystearate/stearate/eicosadioate Polyglyceryl-10 Isostearate Polyglyceryl-10 Laurate Polyglyceryl-10 Lioleate Polyglyceryl-10 Moo/Dioleate Polyglyceryl-10 Myristate Polyglyceryl-10 Noaerucate Polyglyceryl-10 Noaisostearate Polyglyceryl-10 leate Polyglyceryl-10 Palmate Polyglyceryl-10 Palmitate Polyglyceryl-10 Petacaprylate Polyglyceryl-10 Petahydroxystearate Polyglyceryl-10 Petaisostearate Polyglyceryl-10 Petalaurate Polyglyceryl-10 Petalioleate Polyglyceryl-10 Petaoleate Polyglyceryl-10 Petaricioleate Polyglyceryl-10 Petastearate Polyglyceryl-10 Sesquistearate Polyglyceryl-10 Stearate Polyglyceryl-10 Tetradecaedioate Polyglyceryl-10 Tetralaurate Polyglyceryl-10 Tetraoleate Polyglyceryl-10 Tricocoate Polyglyceryl-10 Tridecaoate Polyglyceryl-10 Trierucate Polyglyceryl-10 Triisostearate Polyglyceryl-10 Trilaurate Polyglyceryl-10 Trioleate Polyglyceryl-10 Tristearate Polyglyceryl-10 Udecyleate Polyglyceryl-15 Diisostearate Polyglyceryl-20 Docosabeheate/Isostearate Polyglyceryl-20 Docosabeheate/Laurate Polyglyceryl-20 Docosabeheate/leate Polyglyceryl-20 eptacaprylate Polyglyceryl-20 eptadecabeheate/laurate Polyglyceryl-20 exacaprylate Polyglyceryl-20 ctadecabeheate/laurate Polyglyceryl-20 ctaisooaoate Pumpki Seed il Polyglyceryl-4 Esters Pumpki Seed il Polyglyceryl-4 Esters Succiate ice Bra il Polyglyceryl-3 Esters osa ubigiosa Seed il Polyglyceryl-6 Esters Safflower Seed il Polyglyceryl-6 Esters Schiziophyto autaeii Kerel il Polyglyceryl-6 Esters Sclerocarya Birrea Seed il Polyglyceryl-6 Esters Sclerocarya Birrea Seed il Polyglyceryl-10 Esters Sesame il Polyglyceryl-6 Esters Shea Butter Polyglyceryl-3 Esters Shea Butter Polyglyceryl-4 Esters Shea Butter Polyglyceryl-6 Esters Soybea il Polyglyceryl-6 Esters Suflower Seed il Polyglyceryl-3 Esters Suflower Seed il Polyglyceryl-4 Esters Suflower Seed il Polyglyceryl-5 Esters Suflower Seed il Polyglyceryl-6 Esters Suflower Seed il Polyglyceryl-10 Esters Sweet Almod il Polyglyceryl-4 Esters Sweet Almod il Polyglyceryl-6 Esters Theobroma Gradiflorum Seed Butter Polyglyceryl-6 Esters Trichilia Emetica Seed il Polyglyceryl-6 Esters Triisostearoyl Polyglyceryl-3 Dimer Dilioleate Watermelo Seed il Polyglyceryl-6 Esters Watermelo Seed il Polyglyceryl-10 Esters Ximeia Americaa Seed il Polyglyceryl-6 Esters

37 Distributed for Commet ly -- Do Not Cite or Quote Table 2. Polyglyceryl Fatty Acid Esters arraged by polyglyceryl chai legth Polyglyceryl-2 discrete esters Polyglyceryl-2 Caprate Polyglyceryl-2 Caprylate Polyglyceryl-2 Laurate Polyglyceryl-2 Myristate Polyglyceryl-2 Isopalmitate Polyglyceryl-2 Palmitate Polyglyceryl-2 Isostearate Polyglyceryl-2 leate Polyglyceryl-2 Stearate Polyglyceryl-2 mixed esters Polyglyceryl-2 Isopalmitate/Sebacate Polyglyceryl Mooesters Polyglyceryl-5 discrete esters Polyglyceryl-5 Caprate Polyglyceryl-5 Laurate Polyglyceryl-5 Myristate Polyglyceryl-5 Isostearate Polyglyceryl-5 leate Polyglyceryl-5 Stearate Polyglyceryl-5 icioleate Polyglyceryl-5 mixed esters Apricot Kerel il Polyglyceryl-5 Esters Palm il Polyglyceryl-5 Esters Suflower Seed il Polyglyceryl-5 Esters Polyglyceryl-6 mixed esters (co t) Soybea il Polyglyceryl-6 Esters Suflower Seed il Polyglyceryl-6 Esters Sweet Almod il Polyglyceryl-6 Esters Theobroma Gradiflorum Seed Butter Polyglyceryl-6 Esters Trichilia Emetica Seed il Polyglyceryl-6 Esters Watermelo Seed il Polyglyceryl-6 Esters Ximeia Americaa Seed il Polyglyceryl-6 Esters Polyglyceryl-8 discrete esters Polyglyceryl-8 leate Polyglyceryl-8 Stearate Polyglyceryl-3 discrete esters Polyglyceryl-3 Caprate Polyglyceryl-3 Caprylate Polyglyceryl-3 Laurate Polyglyceryl-3 Myristate Polyglyceryl-3 Palmitate Polyglyceryl-3 Isostearate Polyglyceryl-3 leate Polyglyceryl-3 Stearate Polyglyceryl-3 Stearate SE Polyglyceryl-3 icioleate Polyglyceryl-3 Beheate Polyglyceryl-3 mixed esters Acacia Decurres/Jojoba/Suflower Seed Wax Polyglyceryl 3 Esters Apricot Kerel il Polyglyceryl-3 Esters Cadelilla/Jojoba/ice Bra Polyglyceryl-3 Esters live il Polyglyceryl-3 Esters Palm il Polyglyceryl-3 Esters Polyglyceryl-3 Beeswax Polyglyceryl-3 Cocoate Polyglyceryl-3 ice Braate Polyglyceryl-3 Soyate/Shea Butterate ice Bra il Polyglyceryl-3 Esters Shea Butter Polyglyceryl-3 Esters Suflower Seed il Polyglyceryl-3 Esters Polyglyceryl-4 discrete esters Polyglyceryl-4 Caprate Polyglyceryl-4 Caprylate Polyglyceryl-4 Laurate Polyglyceryl-4 Isostearate Polyglyceryl-4 leate Polyglyceryl-4 Stearate Polyglyceryl-4 mixed esters Apricot Kerel il Polyglyceryl-4 Esters Babassu il Polyglyceryl-4 Esters Borage Seed il Polyglyceryl-4 Esters Liseed il Polyglyceryl-4 Esters live il Polyglyceryl-4 Esters Palm Kerel il Polyglyceryl-4 Esters Palm il Polyglyceryl-4 Esters Polyglyceryl-4 Almodate/Shea Butterate Polyglyceryl-4 Caprylate/Caprate Polyglyceryl-4 Cocoate Polyglyceryl-4 azelutseedate Polyglyceryl-4 Isostearate/Laurate Polyglyceryl-4 Laurate/Sebacate Polyglyceryl-4 Laurate/Succiate Polyglyceryl-4 Puicate Polyglyceryl-4 Sweet Almodate Shea Butter Polyglyceryl-4 Esters Suflower Seed il Polyglyceryl-4 Esters Sweet Almod il Polyglyceryl-4 Esters Polyglyceryl-6 discrete esters Polyglyceryl-6 Caprate Polyglyceryl-6 Caprylate Polyglyceryl-6 Udecyleate Polyglyceryl-6 Laurate Polyglyceryl-6 Myristate Polyglyceryl-6 Palmitate Polyglyceryl-6 Isostearate Polyglyceryl-6 leate Polyglyceryl-6 Stearate Polyglyceryl-6 icioleate Polyglyceryl-6 Beheate Polyglyceryl-6 mixed esters Adasoia Digitata Seed il Polyglyceryl-6 Esters Apricot Kerel il Polyglyceryl-6 Esters Arga il Polyglyceryl-6 Esters Astrocaryum Vulgare il Polyglyceryl-6 Esters Avocado il Polyglyceryl-6 Esters Babassu il Polyglyceryl-6 Esters Bertholletia Excelsa Seed il Polyglyceryl-6 Esters Borage Seed il Polyglyceryl-6 Esters Carapa Guaiaesis il Polyglyceryl-6 Esters Castor il Polyglyceryl-6 Esters Cocoa Butter Polyglyceryl-6 Esters Cocout il Polyglyceryl-6 Esters Coffee Seed il Polyglyceryl-6 Esters Glyceryl/Polyglyceryl-6 Isostearate/Beheate Esters azelut Seed il Polyglyceryl-6 Esters Macadamia Seed il Polyglyceryl-6 Esters Mauritia Flexuosa Seed il Polyglyceryl-6 Esters live il Polyglyceryl-6 Esters Palm il Polyglyceryl-6 Esters Pariari Curatellifolia il Polyglyceryl-6 Esters Pius Sibirica Seed il Polyglyceryl-6 Esters Polyglyceryl-6 Adasoia Digitata Seedate Polyglyceryl-6 Apricot Kerelate Polyglyceryl-6 Arga Kerelate Polyglyceryl-6 Caprylate/Caprate Polyglyceryl-6 Citrullus Laatus Seedate Polyglyceryl-6 Palmitate/Succiate Polyglyceryl-6 Schiziophyto autaeii Kerelate Polyglyceryl-6 Sclerocarya Birrea Seedate Polyglyceryl-6 Trichilia Emetica Seedate Polyglyceryl-6 Ximeia Americaa Seedate osa ubigiosa Seed il Polyglyceryl-6 Esters Safflower Seed il Polyglyceryl-6 Esters Schiziophyto autaeii Kerel il Polyglyceryl-6 Esters Sclerocarya Birrea Seed il Polyglyceryl-6 Esters Sesame il Polyglyceryl-6 Esters Shea Butter Polyglyceryl-6 Esters Polyglyceryl-8 mixed esters Polyglyceryl-8 C12-20 Acid Ester Polyglyceryl-10 discrete esters Polyglyceryl-10 Caprate Polyglyceryl-10 Caprylate Polyglyceryl-10 Udecyleate Polyglyceryl-10 Laurate Polyglyceryl-10 Myristate Polyglyceryl-10 Palmitate Polyglyceryl-10 Isostearate Polyglyceryl-10 Lioleate Polyglyceryl-10 leate Polyglyceryl-10 Stearate Polyglyceryl-10 mixed esters Almod il/polyglyceryl-10 Esters Apricot Kerel il Polyglyceryl-10 Esters Caprylic/Capric Glycerides Polyglyceryl-10 Esters Polyglyceryl-10 Apricot Kerelate Polyglyceryl-10 Beheate/Eicosadioate Polyglyceryl-10 Caprylate/Caprate Polyglyceryl-10 Cocoate Polyglyceryl-10 Eicosaedioate/Tetradecaedioate Polyglyceryl-10 ydroxystearate/stearate/ Eicosadioate Polyglyceryl-10 Palmate Sclerocarya Birrea Seed il Polyglyceryl-10 Esters Suflower Seed il Polyglyceryl-10 Esters Watermelo Seed il Polyglyceryl-10 Esters

38 Distributed for Commet ly -- Do Not Cite or Quote Table 2. Polyglyceryl Fatty Acid Esters arraged by polyglyceryl chai legth Polyglyceryl-2 discrete multi-esters Polyglyceryl-2 Sesquicaprylate Polyglyceryl-2 Sesquiisostearate Polyglyceryl-2 Diisostearate Polyglyceryl-2 Triisostearate Polyglyceryl-2 Tetraisostearate Polyglyceryl-2 Dioleate Polyglyceryl-2 Sesquioleate Polyglyceryl-2 Tetraoleate Polyglyceryl-2 Sesquistearate Polyglyceryl-2 Distearate Polyglyceryl-2 Tetrastearate Polyglyceryl-2 mixed multi-esters Polyglyceryl-2 Tetrabeheate/ Macadamiate/Sebacate Polyglyceryl-3 discrete multi-esters Polyglyceryl-3 Dicaprate Polyglyceryl-3 Diisostearate Polyglyceryl-3 Triisostearate Polyglyceryl-3 Dioleate Polyglyceryl-3 Distearate Polyglyceryl-3 Di-ydroxystearate Polyglyceryl-3 Petaricioleate Polyglyceryl-3 mixed multi-esters Diisostearoyl Polyglyceryl-3 Dimer Dilioleate Polyglyceryl-3 Dicitrate/Stearate Polyglyceryl-3 Dicocoate Polyglyceryl-3 Petacaprylate/Caprate Polyglyceryl-3 Petaolivate Polyglyceryl-3 Triolivate Triisostearoyl Polyglyceryl-3 Dimer Dilioleate Polyglyceryl-4 discrete multi-esters Polyglyceryl-4 Dilaurate Polyglyceryl-4 Petaoleate Polyglyceryl-4 Distearate Polyglyceryl-4 Tristearate Polyglyceryl-4 Petastearate Polyglyceryl-4 mixed multi-esters Polyglyceryl-4 Petapalmitate/Stearate Pumpki Seed il Polyglyceryl-4 Esters Pumpki Seed il Polyglyceryl-4 Esters Succiate Polyglyceryl-5 discrete multi-esters Polyglyceryl-5 Dicaprylate Polyglyceryl-5 Dilaurate Polyglyceryl-5 Trimyristate Polyglyceryl-5 Petamyristate Polyglyceryl-5 Triisostearate Polyglyceryl-5 Dioleate Polyglyceryl-5 Trioleate Polyglyceryl-5 Tristearate Polyglyceryl-5 exastearate Polyglyceryl-5 Tribeheate Polyglyceryl Multi-esters (i.e., ot moo-esters ad ot polyesters ) Polyglyceryl-6 discrete multi-esters Polyglyceryl-6 Sesquicaprylate Polyglyceryl-6 Dicaprate Polyglyceryl-6 Tricaprylate Polyglyceryl-6 Tetracaprylate Polyglyceryl-6 Petacaprylate Polyglyceryl-6 eptacaprylate Polyglyceryl-6 ctacaprylate Polyglyceryl-6 Dipalmitate Polyglyceryl-6 Sesquiisostearate Polyglyceryl-6 Diisostearate Polyglyceryl-6 Dioleate Polyglyceryl-6 Tetraoleate Polyglyceryl-6 Petaoleate Polyglyceryl-6 exaoleate Polyglyceryl-6 Sesquistearate Polyglyceryl-6 Distearate Polyglyceryl-6 Tristearate Polyglyceryl-6 Petastearate Polyglyceryl-6 exastearate Polyglyceryl-6 ctastearate Polyglyceryl-6 Petaricioleate Polyglyceryl-6 Tetrabeheate Polyglyceryl-6 mixed multi-ester Macadamia Seed il Polyglyceryl-6 Esters Beheate Polyglyceryl-8 mixed multi-esters Polyglyceryl-8 Decabeheate/Caprate Polyglyceryl-8 Decaerucate/Decaisostearate/ Decaricioleate Polyglyceryl-10 discrete multi-esters Polyglyceryl-10 Decaethylhexaoate Polyglyceryl-10 Dodecacaprate Polyglyceryl-10 Petacaprylate Polyglyceryl-10 Dodecacaprylate Polyglyceryl-10 Tridecaoate Polyglyceryl-10 Dilaurate Polyglyceryl-10 Trilaurate Polyglyceryl-10 Tetralaurate Polyglyceryl-10 Petalaurate Polyglyceryl-10 Dimyristate Polyglyceryl-10 Dipalmitate Polyglyceryl-10 Diisostearate Polyglyceryl-10 Triisostearate Polyglyceryl-10 Petaisostearate Polyglyceryl-10 exaisostearate Polyglyceryl-10 Noaisostearate Polyglyceryl-10 Decaisostearate Polyglyceryl-10 Petalioleate Polyglyceryl-10 Decalioleate Polyglyceryl-10 Dioleate Polyglyceryl-10 Trioleate Polyglyceryl-10 Tetraoleate Polyglyceryl-10 Petaoleate Polyglyceryl-10 discrete multi-esters (co t) Polyglyceryl-10 Petaricioleate Polyglyceryl-10 exaoleate Polyglyceryl-10 eptaoleate Polyglyceryl-10 Decaoleate Polyglyceryl-10 Distearate Polyglyceryl-10 Tristearate Polyglyceryl-10 Petastearate Polyglyceryl-10 Petahydroxystearate Polyglyceryl-10 eptahydroxystearate Polyglyceryl-10 eptastearate Polyglyceryl-10 Decahydroxystearate Polyglyceryl-10 Decastearate Polyglyceryl-10 Dodecabeheate Polyglyceryl-10 Trierucate Polyglyceryl-10 exaerucate Polyglyceryl-10 Noaerucate Polyglyceryl-10 mixed multi-esters Polyglyceryl-10 Decamacadamiate Polyglyceryl-10 Dicocoate Polyglyceryl-10 Didecaoate Polyglyceryl-10 Dodeca-Caprylate/ Caprate Polyglyceryl-10 epta(beheate/stearate) Polyglyceryl-10 Moo/Dioleate Polyglyceryl-10 Sesquistearate Polyglyceryl-10 Tetradecaedioate Polyglyceryl-10 Tricocoate Polyglyceryl-15 discrete multi-ester Polyglyceryl-15 Diisostearate Polyglyceryl-20 discrete multi-esters Polyglyceryl-20 exacaprylate Polyglyceryl-20 eptacaprylate Polyglyceryl-20 ctaisooaoate Polyglyceryl-20 mixed multi-esters Polyglyceryl-20 Docosabeheate/Isostearate Polyglyceryl-20 Docosabeheate/Laurate Polyglyceryl-20 Docosabeheate/leate Polyglyceryl-20 eptadecabeheate/laurate Polyglyceryl-20 ctadecabeheate/laurate

39 Distributed for Commet ly -- Do Not Cite or Quote 1 ( CI Staff) Table 3. Defiitios, idealized structures, ad fuctio Igrediet CAS No. Defiitio & Structure Fuctio(s) Polyglyceryl Mooesters Polyglyceryl-2 discrete esters Polyglyceryl-2 Caprate Polyglyceryl-2 Caprylate Polyglyceryl-2 Laurate Polyglyceryl-2 Myristate Polyglyceryl-2 Isopalmitate Polyglyceryl-2 Palmitate Polyglyceryl-2 Isostearate Polyglyceryl-2 leate (geeric) Polyglyceryl-2 Stearate (geeric) Polyglyceryl-2 mixed esters Polyglyceryl-2 Isopalmitate/Sebacate the ester of capric acid ad diglyceri wherei is 2 the ester of caprylic acid ad diglyceri C 3 wherei is 2 the ester of lauric acid ad diglyceri wherei is 2 the mooester of myristic acid ad diglycerol wherei is 2 a ester of isopalmitic acid ad diglyceri wherei is 2 (oe example of a iso ) the mooester of palmitic acid ad diglycerol wherei is 2 the ester of isostearic acid ad diglyceri wherei is 2 (oe example of a iso ) a ester of oleic acid ad diglyceri C 3 wherei is 2 the ester of stearic acid ad diglyceri wherei is 2 the mixed ester of isopalmitic acid, sebacic acid ad diglyceri C 3 C 3 C 3 C 3 C 3 C 3 C 3 C 3 C 3 ski-coditioig aget - emolliet; surfactat - emulsifyig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget surfactat - emulsifyig aget wherei C()- represets the residue of isopalmitic or sebacic acid, ad is 2

40 Distributed for Commet ly -- Do Not Cite or Quote 1 ( CI Staff) Table 3. Defiitios, idealized structures, ad fuctio Igrediet CAS No. Defiitio & Structure Fuctio(s) Polyglyceryl-3 discrete esters Polyglyceryl-3 Caprate a ester of capric acid ad polyglyceri-3 ski-coditioig aget - emolliet; C surfactat emulsifyig aget Polyglyceryl-3 Caprylate wherei is 3 the ester of caprylic acid ad polyglyceri-3 C 3 deodorat aget; surfactats - emulsifyig aget Polyglyceryl-3 Laurate Polyglyceryl-3 Myristate Polyglyceryl-3 Palmitate Polyglyceryl-3 Isostearate Polyglyceryl-3 leate (geeric) Polyglyceryl-3 Stearate (geeric) Polyglyceryl-3 Stearate SE wherei is 3 the ester of lauric acid ad polyglyceri-3 C 3 wherei is 3 the ester of myristic acid ad polyglyceri-3 C 3 wherei is 3 a ester of palmitic acid ad polyglyceri-3 C 3 wherei is 3 the ester of isostearic acid ad polyglyceri-3 C 3 C 3 wherei is 3 (oe example of a iso ) a ester of oleic acid ad polyglyceri-3 C 3 wherei is 3 a ester of stearic acid ad polyglyceri-3 C 3 wherei is 3 a self-emulsifyig grade of polyglyceryl-3 stearate that cotais some sodium ad/or potassium stearate ski-coditioig aget - emolliet; surfactat - emulsifyig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget surfactat - emulsifyig aget C 3 wherei is 3 ad Polyglyceryl-3 icioleate (geeric) - M + wherei M is sodium or potassium a ester of ricioleic acid ad polyglyceri-3 C 3 C 3 ski-coditioig aget - emolliet; surfactat - emulsifyig aget wherei is 3

41 Distributed for Commet ly -- Do Not Cite or Quote 1 ( CI Staff) Table 3. Defiitios, idealized structures, ad fuctio Igrediet CAS No. Defiitio & Structure Fuctio(s) Polyglyceryl-3 Beheate the ester of beheic acid ad polyglyceri-3 emulsio stabilizer; slip modifier; C 3 surface modifier Polyglyceryl-3 mixed esters Acacia Decurres/Jojoba/Suflower Seed Wax Polyglyceryl 3 Esters wherei is 3 the product obtaied by the trasesterificatio of polyglyceri-3 with a mixture of acacia decurres flower wax, simmodsia chiesis (jojoba) seed wax, ad heliathus auus (suflower) seed wax ski-coditioig aget - emolliet Apricot Kerel il Polyglyceryl-3 Esters wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from acacia decurres flower wax, simmodsia chiesis (jojoba) seed wax, ad heliathus auus (suflower) seed wax, ad is 3 the product obtaied by the trasesterificatio of pruus armeiaca (apricot) kerel oil ad polyglyceri-3 ski-coditioig aget - emolliet; surfactat - emulsifyig aget Cadelilla/Jojoba/ice Bra Polyglyceryl-3 Esters wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from pruus armeiaca (apricot) kerel oil, ad is 3 a product obtaied by the trasesterificatio of polyglyceri-3 ad euphorbia cerifera (cadelilla) wax, ad simmodsia chiesis (jojoba) seed wax ad oryza sativa (rice) bra wax emulsio stabilizer; surfactat - emulsifyig aget live il Polyglyceryl-3 Esters wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from euphorbia cerifera (cadelilla) wax, ad simmodsia chiesis (jojoba) seed wax ad oryza sativa (rice) bra wax, ad is 3 the product obtaied by the trasesterificatio of polyglyceri-3 ad olea europaea (olive) fruit oil surfactat emulsifyig aget 4 Palm il Polyglyceryl-3 Esters wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from olea europaea (olive) fruit oil, ad is 3 the product obtaied by the trasesterificatio of polyglyceri-3 ad elaeis guieesis (palm) oil ski-coditioig aget - emolliet; surfactat - emulsifyig aget Polyglyceryl-3 Beeswax wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from elaeis guieesis (palm) oil, ad is 3 a ester of beeswax fatty acids ad polyglyceri-3 surfactat emulsifyig aget Polyglyceryl-3 Cocoate wherei C()- represets the residue of beeswax fatty acids, ad is 3 the ester of cocout acid ad polyglyceri-3 surfactat emulsifyig aget wherei C()- represets the residue of cocout acid, ad is 3

42 Distributed for Commet ly -- Do Not Cite or Quote 1 ( CI Staff) Table 3. Defiitios, idealized structures, ad fuctio Igrediet CAS No. Defiitio & Structure Fuctio(s) Polyglyceryl-3 ice Braate the mooester of polyglyceri-3 ad rice bra acid surfactat emulsifyig aget wherei C()- represets the residue of rice bra acid, ad is 3 Polyglyceryl-3 Soyate/Shea Butterate a ester of a mixture of fatty acids derived from glycie soja (soybea) oil ad butyrospermum parkii (shea) butter with polyglyceri-3 surfactat emulsifyig aget ice Bra il Polyglyceryl-3 Esters wherei C()- represets the residue of the fatty acids obtaied from glycie soja (soybea) oil ad butyrospermum parkii (shea) butter, ad is 3 the product obtaied by the trasesterificatio of oryza sativa (rice) bra oil ad polyglyceri-3 surfactats - emulsifyig aget Shea Butter Polyglyceryl-3 Esters Suflower Seed il Polyglyceryl-3 Esters wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from oryza sativa (rice) bra oil, ad is 3 the product obtaied by the trasesterificatio of polyglyceri-3 ad butyrospermum parkii (shea) butter wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from butyrospermum parkii (shea) butter, ad is 3 the product obtaied by the trasesterificatio of heliathus auus (suflower) seed oil ad polyglyceri-3 emulsio stabilizer; hair coditioig aget; ski-coditioig aget miscellaeous; surfactat - emulsifyig aget; viscosity icreasig aget - aqueous ski-coditioig aget - emolliet; surfactat - emulsifyig aget Polyglyceryl-4 discrete esters Polyglyceryl-4 Caprate Polyglyceryl-4 Caprylate Polyglyceryl-4 Laurate ; (geeric); Polyglyceryl-4 Isostearate wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from heliathus auus (suflower) seed oil, ad is 3 the ester of capric acid ad polyglyceri-4 wherei is 4 the mooester of caprylic acid ad polyglyceri-4 wherei is 4 the ester of lauric acid ad polyglyceri-4 wherei is 4 a ester of isostearic acid ad polyglyceri-4 wherei is 4 (oe example of a iso ) C 3 C 3 C 3 C 3 C 3 ski-coditioig aget - emolliet; surfactat - emulsifyig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget

43 Distributed for Commet ly -- Do Not Cite or Quote 1 ( CI Staff) Table 3. Defiitios, idealized structures, ad fuctio Igrediet CAS No. Defiitio & Structure Fuctio(s) Polyglyceryl-4 leate (geeric) a ester of oleic acid ad polyglyceri-4 C 3 ski-coditioig aget - emolliet; surfactat - emulsifyig aget Polyglyceryl-4 Stearate (geeric) Polyglyceryl-4 mixed esters Apricot Kerel il Polyglyceryl-4 Esters wherei is 4 a ester of stearic acid ad polyglyceri-4 wherei is 4 the product obtaied by the trasesterificatio of pruus armeiaca (apricot) kerel oil ad polyglyceri-4 C 3 surfactat - emulsifyig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget Babassu il Polyglyceryl-4 Esters wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from pruus armeiaca (apricot) kerel oil, ad is 4 the product of the trasesterificatio of orbigya oleifera seed oil ad polyglyceri-4 surfactat - solubilizig aget Borage Seed il Polyglyceryl-4 Esters Liseed il Polyglyceryl-4 Esters live il Polyglyceryl-4 Esters wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from orbigya oleifera seed oil, ad is 4 the product obtaied by the trasesterificatio of borago officialis seed oil ad polyglyceri-4 wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from borago officialis seed oil, ad is 4 the product obtaied by the trasesterificatio of lium usitatissimum (liseed) seed oil ad polyglyceri-4 wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from lium usitatissimum (liseed) seed oil, ad is 4 the product obtaied by the trasesterificatio of olea europaea (olive) fruit oil ad polyglyceri-4 opacifyig aget; surfactat - emulsifyig aget; surfactat - solubilizig aget opacifyig aget; surfactat - emulsifyig aget; surfactat - solubilizig aget surfactat - solubilizig aget Palm Kerel il Polyglyceryl-4 Esters wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from olea europaea (olive) fruit oil, ad is 4 is the product obtaied by the trasesterificatio of elaeis guieesis (palm) kerel oil ad polyglyceri-4 wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from elaeis guieesis (palm) kerel oil, ad is 4 opacifyig aget; surfactat - emulsifyig aget; surfactat - solubilizig aget

44 Distributed for Commet ly -- Do Not Cite or Quote 1 ( CI Staff) Table 3. Defiitios, idealized structures, ad fuctio Igrediet CAS No. Defiitio & Structure Fuctio(s) Palm il Polyglyceryl-4 Esters the product obtaied by the trasesterificatio of polyglyceri-4 ad elaeis guieesis (palm) oil ski-coditioig aget - emolliet; surfactat - emulsifyig aget Polyglyceryl-4 Almodate/Shea Butterate wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from elaeis guieesis (palm) oil, ad is 4 a ester of a mixture of fatty acids derived from almod oil ad butyrospermum parkii (shea) butter with polyglyceri-4 surfactat - emulsifyig aget Polyglyceryl-4 Caprylate/Caprate wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from butyrospermum parkii (shea) butter, ad is 4 the mooester of polyglyceri-4 ad a mixture of caprylic ad capric acids surfactat hydrotrope; surfactat solubilizig aget Polyglyceryl-4 Cocoate wherei C()- represets the residue of capric or caprylic acid, ad is 4 a ester of cocout acid ad polyglyceri-4 surfactat - emulsifyig aget Polyglyceryl-4 azelutseedate wherei C()- represets the residue of cocout acid, ad is 4 a ester of the fatty acids derived from corylus avellaa (hazelut) seed oil with polyglyceri-4 surfactat - emulsifyig aget Polyglyceryl-4 Isostearate/Laurate Polyglyceryl-4 Laurate/Sebacate Polyglyceryl-4 Laurate/Succiate wherei C()- represets the residue of the fatty acids derived from corylus avellaa (hazelut) seed oil, ad is 4 the ester of a mixture of isostearic ad lauric acids with polyglyceri-4 wherei C()- represets the residue of isostearic or lauric acid, ad is 4 the mooester of polyglyceri-4 ad a mixture of lauric ad sebacic acids wherei C()- represets the residue of lauric or sebacic acid, ad is 4 the mooester of polyglyceri-4 ad a mixture of lauric ad succiic acids dispersig aget - osurfactat; emulsio stabilizer; surfactat - emulsifyig aget; surfactat - foam booster surfactat hydrotrope; surfactat solublizig aget surfactat - emulsifyig aget Polyglyceryl-4 Puicate wherei C()- represets the residue of lauric or succiic acid, ad is 4 the ester of polyglyceri-4 ad puicic acid surfactat - emulsifyig aget Polyglyceryl-4 Sweet Almodate wherei C()- represets the residue of puicic acid, ad is 4 a ester of the fatty acids derived from sweet almod oil ad polyglyceri-4 wherei C()- represets the residue of the fatty acids obtaied from sweet almod oil, ad is 4 ski-coditioig aget - misc; surfactat - emulsifyig aget

45 Distributed for Commet ly -- Do Not Cite or Quote 1 ( CI Staff) Table 3. Defiitios, idealized structures, ad fuctio Igrediet CAS No. Defiitio & Structure Fuctio(s) Shea Butter Polyglyceryl-4 Esters the product obtaied by the trasesterificatio of butyrospermum parkii (shea) butter ad polyglyceri-4 emulsio stabilizer; ski-coditioig aget emolliet Suflower Seed il Polyglyceryl-4 Esters wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from butyrospermum parkii (shea) butter, ad is 4 the product obtaied by the trasesterificatio of heliathus auus (suflower) seed oil ad polyglyceri-4 ski-coditioig aget - emolliet; surfactat - emulsifyig aget Sweet Almod il Polyglyceryl-4 Esters (geeric) wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from heliathus auus (suflower) seed oil, ad is 4 the product obtaied by the trasesterificatio of pruus amygdalus dulcis (sweet almod) oil ad polyglyceri-4 surfactats - solubilizig aget Polyglyceryl-5 discrete esters Polyglyceryl-5 Caprate Polyglyceryl-5 Laurate ; (geeric) wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from pruus amygdalus dulcis (sweet almod) oil, ad is 4 the mooester of capric acid ad polyglyceri-5 C 3 wherei is 5 the ester of lauric acid ad a glyceri polymer cotaiig a average of 5 glyceri uits C 3 ski-coditioig aget - emolliet; surfactat - emulsifyig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget Polyglyceryl-5 Myristate wherei is 5 the mooester of myristic acid ad a glyceri polymer cotaiig 5 uits of glyceri C 3 ski-coditioig aget - emolliet; surfactat - emulsifyig aget wherei is 5 Polyglyceryl-5 Isostearate the ester of isostearic acid ad a glyceri polymer cotaiig a average of 5 glyceri uits C 3 ski-coditioig aget - emolliet; surfactat - emulsifyig aget Polyglyceryl-5 leate (geeric) C 3 wherei is 5 (oe example of a iso ) the ester of oleic acid ad a glyceri polymer cotaiig a average of 5 glyceri uits C 3 ski-coditioig aget - emolliet; surfactat - emulsifyig aget Polyglyceryl-5 Stearate (geeric) wherei is 5 the mooester of stearic acid ad a glyceri polymer cotaiig 5 uits of glyceri surfactat - emulsifyig aget C 3 wherei is 5

46 Distributed for Commet ly -- Do Not Cite or Quote 1 ( CI Staff) Table 3. Defiitios, idealized structures, ad fuctio Igrediet CAS No. Defiitio & Structure Fuctio(s) Polyglyceryl-5 icioleate is the product obtaied by the reactio of ricioleic acid with a glyceri polymer cotaiig 5 glyceri uits surfactat - emulsifyig aget C 3 Polyglyceryl-5 mixed esters Apricot Kerel il Polyglyceryl-5 Esters wherei is 5 the product obtaied by the trasesterificatio of pruus armeiaca (apricot) kerel oil ad polyglyceri-5 ski-coditioig aget - emolliet; surfactat - emulsifyig aget Palm il Polyglyceryl-5 Esters wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from pruus armeiaca (apricot) kerel oil, ad is 5 the product obtaied by the trasesterificatio of a glyceri polymer cotaiig 5 uits of glyceri ad elaeis guieesis (palm) oil ski-coditioig aget - emolliet; surfactat - emulsifyig aget Suflower Seed il Polyglyceryl-5 Esters wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from elaeis guieesis (palm) oil, ad is 5 the product obtaied by the trasesterificatio of heliathus auus (suflower) seed oil ad a glyceri polymer cotaiig 5 uits of glyceri ski-coditioig aget - emolliet; surfactat - emulsifyig aget Polyglyceryl-6 discrete esters Polyglyceryl-6 Caprate Polyglyceryl-6 Caprylate Polyglyceryl-6 Udecyleate wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from heliathus auus (suflower) seed oil, ad is 5 the mooester of capric acid ad polyglyceri-6 wherei is 6 the mooester of caprylic acid ad polyglyceri-6 wherei is 6 a ester of udecyleic acid ad polyglyceri-6 C 3 C 3 C 3 surfactat - cleasig aget; surfactat - emulsifyig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget surfactat - emulsifyig aget Polyglyceryl-6 Laurate ; (geeric) wherei is 6 the ester of lauric acid ad polyglyceri-6 C 3 ski-coditioig aget - emolliet; surfactat - emulsifyig aget Polyglyceryl-6 Myristate wherei is 6 the mooester of myristic acid ad polyglyceri-6 C 3 ski-coditioig aget - emolliet; surfactat - emulsifyig aget Polyglyceryl-6 Palmitate wherei is 6 the ester of palmitic acid ad polyglyceri-6 C 3 ski-coditioig aget - emolliet; surfactat - emulsifyig aget wherei is 6

47 Distributed for Commet ly -- Do Not Cite or Quote 1 ( CI Staff) Table 3. Defiitios, idealized structures, ad fuctio Igrediet CAS No. Defiitio & Structure Fuctio(s) Polyglyceryl-6 Isostearate the ester of isostearic acid ad polyglyceri-6 ski-coditioig aget - emolliet; C 3 surfactat - emulsifyig aget Polyglyceryl-6 leate (geeric) Polyglyceryl-6 Stearate Polyglyceryl-6 icioleate Polyglyceryl-6 Beheate wherei is 6 (oe example of a iso ) the ester of oleic acid ad polyglyceri-6 wherei is 6 the ester of stearic acid ad polyglyceri-6 wherei is 6 the ester of polyglyceri-6 ad ricioleic acid wherei is 6 the mooester of beheic acid ad polyglyceri-6 C 3 C 3 C 3 C 3 C 3 ski-coditioig aget - emolliet; surfactat - emulsifyig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget emulsio stabilizer; slip modifier; surface modifier Polyglyceryl-6 mixed esters Adasoia Digitata Seed il Polyglyceryl-6 Esters wherei is 6 the product obtaied by the trasesterificatio of adasoia digitata seed oil ad polyglyceri-6 ski-coditioig aget - emolliet; surfactat - emulsifyig aget Apricot Kerel il Polyglyceryl-6 Esters wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from adasoia digitata seed oil, ad is 6 the product obtaied by the trasesterificatio of pruus armeiaca (apricot) kerel oil ad polyglyceri-6 ski-coditioig aget - emolliet; surfactat - emulsifyig aget Arga il Polyglyceryl-6 Esters wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from pruus armeiaca (apricot) kerel oil, ad is 6 the product obtaied by the trasesterificatio of argaia spiosa kerel oil ad polyglyceri-6 ski-coditioig aget - emolliet; surfactat - emulsifyig aget Astrocaryum Vulgare il Polyglyceryl-6 Esters wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from argaia spiosa kerel oil, ad is 6 the product obtaied by the trasesterificatio of astrocaryum vulgare kerel oil ad polyglyceri-6 ski-coditioig aget - misc; surfactat - emulsifyig aget wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from astrocaryum vulgare kerel oil, ad is 6

48 Distributed for Commet ly -- Do Not Cite or Quote 1 ( CI Staff) Table 3. Defiitios, idealized structures, ad fuctio Igrediet CAS No. Defiitio & Structure Fuctio(s) Avocado il Polyglyceryl-6 Esters the product obtaied by the trasesterificatio of persea gratissima (avocado) oil ad polyglyceri-6 ski-coditioig aget - emolliet; surfactat - emulsifyig aget Babassu il Polyglyceryl-6 Esters wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from persea gratissima (avocado) oil, ad is 6 the product obtaied by the trasesterificatio of orbigya oleifera seed oil ad polyglyceri-6 ski-coditioig aget - emolliet; surfactat - emulsifyig aget Bertholletia Excelsa Seed il Polyglyceryl-6 Esters wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from orbigya oleifera seed oil, ad is 6 the product obtaied by the trasesterificatio of bertholletia excelsa seed oil ad polyglyceri-6 ski-coditioig aget - emolliet; surfactat - emulsifyig aget Borage Seed il Polyglyceryl-6 Esters wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from bertholletia excelsa seed oil, ad is 6 the product obtaied by the trasesterificatio of borago officialis seed oil ad polyglyceri-6 ski-coditioig aget - emolliet; surfactat - emulsifyig aget Carapa Guaiaesis il Polyglyceryl-6 Esters wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from borago officialis seed oil, ad is 6 the product obtaied by the trasesterificatio of carapa guaiaesis seed oil ad polyglyceri-6 ski-coditioig aget - emolliet Castor il Polyglyceryl-6 Esters Cocoa Butter Polyglyceryl-6 Esters wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from carapa guaiaesis seed oil, ad is 6 the product obtaied by the trasesterificatio of ricius commuis (castor) seed oil ad polyglyceri-6 wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from ricius commuis (castor) seed oil, ad is 6 the product obtaied by the trasesterificatio of theobroma cacao (cocoa) seed butter ad polyglyceri-6 ski-coditioig aget - emolliet; ski coditioig aget misc; surfactat - emulsifyig aget ski-coditioig aget - emolliet Cocout il Polyglyceryl-6 Esters wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from theobroma cacao (cocoa) seed butter, ad is 6 the product obtaied by the trasesterificatio of cocos ucifera (cocout) oil with polyglyceri-6 ski-coditioig aget - emolliet; surfactat - emulsifyig aget wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from cocos ucifera (cocout) oil, ad is 6

49 Distributed for Commet ly -- Do Not Cite or Quote 1 ( CI Staff) Table 3. Defiitios, idealized structures, ad fuctio Igrediet CAS No. Defiitio & Structure Fuctio(s) Coffee Seed il Polyglyceryl-6 Esters the product obtaied by the trasesterificatio of polyglyceri-6 ad coffea arabica (coffee) seed oil ski-coditioig aget - emolliet; surfactat - emulsifyig aget Glyceryl/Polyglyceryl-6 Isostearate/Beheate Esters wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from coffea arabica (coffee) seed oil, ad is 6 the mixture of esters formed by the reactio of glyceri ad polyglyceri-6 with isostearic acid ad beheic acid ski-coditioig aget - emolliet azelut Seed il Polyglyceryl-6 Esters wherei C()- represets the residue of isostearic or beheic acid, ad is 1 or 6 the product obtaied by the trasesterificatio of corylus avellaa (hazelut) seed oil ad polyglyceri-6 ski-coditioig aget - emolliet; surfactat - emulsifyig aget Macadamia Seed il Polyglyceryl-6 Esters wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from corylus avellaa (hazelut) seed oil, ad is 6 the product obtaied by the trasesterificatio of macadamia terifolia seed oil ad polyglyceri-6 ski-coditioig aget - emolliet; surfactat - emulsifyig aget Mauritia Flexuosa Seed il Polyglyceryl-6 Esters wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from macadamia terifolia seed oil, ad is 6 the product obtaied by the trasesterificatio of the oil obtaied from the seeds of Mauritia flexuosa ad polyglyceri-6 ski-coditioig aget - emolliet; surfactat - emulsifyig aget live il Polyglyceryl-6 Esters wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from the seeds of Mauritia flexuosa, ad is 6 the product obtaied by the trasesterificatio of olea europaea (olive) fruit oil ad polyglyceri-6 ski-coditioig aget - emolliet; surfactat - emulsifyig aget Palm il Polyglyceryl-6 Esters wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from olea europaea (olive) fruit oil, ad is 6 the product obtaied by the trasesterificatio of polyglyceri-6 ad elaeis guieesis (palm) oil ski-coditioig aget - emolliet; surfactat - emulsifyig aget Pariari Curatellifolia il Polyglyceryl-6 Esters wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from elaeis guieesis (palm) oil, ad is 6 the product of the trasesterificatio of the oil obtaied from the seeds of Pariari curatellifolia ad polyglyceri-6 ski-coditioig aget - emolliet; surfactat - emulsifyig aget wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from the seeds of Pariari curatellifolia, ad is 6

50 Distributed for Commet ly -- Do Not Cite or Quote 1 ( CI Staff) Table 3. Defiitios, idealized structures, ad fuctio Igrediet CAS No. Defiitio & Structure Fuctio(s) Pius Sibirica Seed il Polyglyceryl-6 Esters the product obtaied by the trasesterificatio of pius sibirica seed oil ad polyglyceri-6 surfactat - emulsifyig aget Polyglyceryl-6 Adasoia Digitata Seedate wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from pius sibirica seed oil, ad is 6 the ester of the fatty acids obtaied from adasoia digitata seed oil ad polyglyceri-6 ski-coditioig aget - emolliet; surfactat - emulsifyig aget Polyglyceryl-6 Apricot Kerelate wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from adasoia digitata seed oil, ad is 6 the ester of the fatty acids derived from pruus armeiaca (apricot) kerel oil ad polyglyceri-6 ski-coditioig aget - emolliet; surfactat - emulsifyig aget Polyglyceryl-6 Arga Kerelate wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from pruus armeiaca (apricot) kerel oil, ad is 6 the ester of polyglyceri-6 ad the fatty acids obtaied from argaia spiosa kerel oil ski-coditioig aget - emolliet; surfactat - emulsifyig aget Polyglyceryl-6 Caprylate/Caprate Polyglyceryl-6 Citrullus Laatus Seedate wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from argaia spiosa kerel oil, ad is 6 the mooester of polyglyceri-6 ad a mixture of caprylic ad capric acids wherei C()- represets the residue of capric or caprylic acid, ad is 6 the ester of the fatty acids derived from citrullus laatus (watermelo) seed oil ad polyglyceri-6 surfactat - hydrotrope; surfactat - solubilizig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget Polyglyceryl-6 Palmitate/Succiate wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from citrullus laatus (watermelo) seed oil, ad is 6 the mooester of polyglyceri-6 ad a mixture of palmitic ad succiic acids surfactat - emulsifyig aget Polyglyceryl-6 Schiziophyto autaeii Kerelate wherei C()- represets the residue of palmitic or succiic acid, ad is 6 the ester of polyglyceri-6 ad the fatty acids obtaied from schiziophyto rautaeii kerel oil ski-coditioig aget - emolliet; surfactat - emulsifyig aget Polyglyceryl-6 Sclerocarya Birrea Seedate wherei C()- represets the residue of the fatty acids obtaied from schiziophyto rautaeii kerel oil, ad is 6 the ester of polyglyceri-6 ad the fatty acids obtaied sclerocarya birrea seed oil ski-coditioig aget - emolliet; surfactat - emulsifyig aget wherei C()- represets the residue of the fatty acids obtaied from sclerocarya birrea seed oil, ad is 6

51 Distributed for Commet ly -- Do Not Cite or Quote 1 ( CI Staff) Table 3. Defiitios, idealized structures, ad fuctio Igrediet CAS No. Defiitio & Structure Fuctio(s) Polyglyceryl-6 Trichilia Emetica Seedate the ester of polyglyceri-6 ad the fatty acids obtaied from trichilia emetica seed butter ski-coditioig aget - emolliet; surfactat - emulsifyig aget Polyglyceryl-6 Ximeia Americaa Seedate wherei C()- represets the residue of the fatty acids obtaied from trichilia emetica seed butter, ad is 6 the ester of polyglyceri-6 ad the fatty acids obtaied from ximeia americaa seed oil ski-coditioig aget - emolliet; surfactat - emulsifyig aget osa ubigiosa Seed il Polyglyceryl-6 Esters Safflower Seed il Polyglyceryl-6 Esters wherei C()- represets the residue of the fatty acids obtaied from ximeia americaa seed oil, ad is 6 the product obtaied by the trasesterificatio of rosa rubigiosa seed oil ad polyglyceri-6 wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from rosa rubigiosa seed oil, ad is 6 the product obtaied by the trasesterificatio of carthamus tictorius (safflower) seed oil ad polyglyceri-6 ski-coditioig aget - emolliet; ski-coditioig aget - miscellaeous; surfactat - emulsifyig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget Schiziophyto autaeii Kerel il Polyglyceryl-6 Esters wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from carthamus tictorius (safflower) seed oil, ad is 6 the product formed by the trasesterificatio of schiziophyto rautaeii kerel oil ad polyglyceri-6 ski-coditioig aget - emolliet; surfactat - emulsifyig aget Sclerocarya Birrea Seed il Polyglyceryl-6 Esters wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from schiziophyto rautaeii kerel oil, ad is 6 the product obtaied by the trasesterificatio of sclerocarya birrea seed oil with polyglyceri-6 ski-coditioig aget - emolliet; surfactat - emulsifyig aget Sesame il Polyglyceryl-6 Esters wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from sclerocarya birrea seed oil, ad is 6 the product obtaied by the trasesterificatio of sesamum idicum (sesame) oil ad polyglyceri-6 ski-coditioig aget - emolliet; surfactat - emulsifyig aget Shea Butter Polyglyceryl-6 Esters wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from sesamum idicum (sesame) oil, ad is 6 the product obtaied by the trasesterificatio of butyrospermum parkii (shea) butter ad polyglyceri-6 ski-coditioig aget - emolliet; surfactat - emulsifyig aget wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from butyrospermum parkii (shea) butter, ad is 6

52 Distributed for Commet ly -- Do Not Cite or Quote 1 ( CI Staff) Table 3. Defiitios, idealized structures, ad fuctio Igrediet CAS No. Defiitio & Structure Fuctio(s) Soybea il Polyglyceryl-6 Esters the product of the trasesterificatio of glycie soja (soybea) oil ad polyglyceri-6 ski-coditioig aget - emolliet; surfactat - emulsifyig aget Suflower Seed il Polyglyceryl-6 Esters wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from glycie soja (soybea) oil, ad is 6 the product obtaied by the trasesterificatio of heliathus auus (suflower) seed oil ad polyglyceri-6 ski-coditioig aget - emolliet; surfactat - emulsifyig aget Sweet Almod il Polyglyceryl-6 Esters wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from heliathus auus (suflower) seed oil, ad is 6 the product obtaied by the trasesterificatio of pruus amygdalus dulcis (sweet almod) oil ad polyglyceri-6 ski-coditioig aget - emolliet; surfactat - emulsifyig aget Theobroma Gradiflorum Seed Butter Polyglyceryl-6 Esters wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from pruus amygdalus dulcis (sweet almod) oil, ad is 6 the product obtaied by the trasesterificatio of theobroma gradiflorum seed butter ad polyglyceri-6 ski-coditioig aget - emolliet; surfactat - emulsifyig aget Trichilia Emetica Seed il Polyglyceryl-6 Esters wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from theobroma gradiflorum seed butter, ad is 6 the product obtaied by the trasesterificatio of trichilia emetica seed butter ad polyglyceri-6 ski-coditioig aget - emolliet; surfactat - emulsifyig aget Watermelo Seed il Polyglyceryl-6 Esters wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from trichilia emetica seed butter, ad is 6 the product obtaied by the trasesterificatio of citrullus laatus (watermelo) seed oil with polyglyceri-6 ski-coditioig aget - emolliet; surfactat - emulsifyig aget Ximeia Americaa Seed il Polyglyceryl-6 Esters wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from citrullus laatus (watermelo) seed oil, ad is 6 the product obtaied by the trasesterificatio of ximeia americaa seed oil ad polyglyceri-6 ski-coditioig aget - emolliet; surfactat - emulsifyig aget Polyglyceryl-8 discrete esters Polyglyceryl-8 leate (geeric) wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from ximeia americaa seed oil, ad is 6 a ester of oleic acid ad a glyceri polymer cotaiig a average of 8 glyceri uits C 3 ski-coditioig aget misc.; surfactat - emulsifyig aget wherei is 8

53 Distributed for Commet ly -- Do Not Cite or Quote 1 ( CI Staff) Table 3. Defiitios, idealized structures, ad fuctio Igrediet CAS No. Defiitio & Structure Fuctio(s) Polyglyceryl-8 Stearate (geeric) a ester of stearic acid ad a glyceri polymer cotaiig a average of 8 glyceri uits surfactat - emulsifyig aget C 3 Polyglyceryl-8 mixed esters Polyglyceryl-8 C12-20 Acid Ester wherei is 8 the ester of a glyceri polymer cotaiig 8 uits of glyceri ad a sythetic mixture of saturated acids cotaiig 12 to 20 carbos i the alkyl chai surfactat - emulsifyig aget Polyglyceryl-10 discrete esters Polyglyceryl-10 Caprate Polyglyceryl-10 Caprylate wherei C()- represets the residue of a fatty acid cotaiig 12 to 20 carbos i the alkyl chai, ad is 8 the ester of capric acid ad polyglyceri-10 wherei is 10 the mooester of caprylic acid ad polyglyceri-10 C 3 C 3 ski-coditioig aget - emolliet; surfactat - emulsifyig aget surfactat - emulsifyig aget Polyglyceryl-10 Udecyleate wherei is 10 a ester of Udecyleic Acid ad polyglyceri-10 surfactat - emulsifyig aget C 3 Polyglyceryl-10 Laurate (geeric) wherei is 10 a ester of lauric acid ad polyglyceri-10 C 3 ski-coditioig aget - misc; surfactat - emulsifyig aget Polyglyceryl-10 Myristate wherei is 10 a ester of myristic acid ad polyglyceri-10 C 3 ski-coditioig aget - emolliet; surfactat - emulsifyig aget Polyglyceryl-10 Palmitate wherei is 10 the ester of palmitic acid ad polyglyceri-10 C 3 ski-coditioig aget - emolliet; surfactat - emulsifyig aget Polyglyceryl-10 Isostearate wherei is 10 the ester of isostearic acid ad polyglyceri-10 C 3 ski-coditioig aget - emolliet; surfactat - emulsifyig aget Polyglyceryl-10 Lioleate wherei is 10 (oe example of a iso ) the mooester of lioleic acid ad polyglyceri-10 C 3 C 3 ski-coditioig aget - emolliet; surfactat - emulsifyig aget wherei is 10

54 Distributed for Commet ly -- Do Not Cite or Quote 1 ( CI Staff) Table 3. Defiitios, idealized structures, ad fuctio Igrediet CAS No. Defiitio & Structure Fuctio(s) Polyglyceryl-10 leate (geeric) a ester of oleic acid ad polyglyceri-10 C 3 ski-coditioig aget - misc; surfactat - emulsifyig aget Polyglyceryl-10 Stearate (geeric) Polyglyceryl-10 mixed esters Almod il/polyglyceryl-10 Esters wherei is 10 a ester of stearic acid ad polyglyceri-10 wherei is 10 the product obtaied by the trasesterificatio of pruus amygdalus dulcis (sweet almod) oil ad polyglyceri-10 C 3 ski-coditioig aget - misc; surfactat - emulsifyig aget surfactat - emulsifyig aget Apricot Kerel il Polyglyceryl-10 Esters wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from pruus amygdalus dulcis (sweet almod) oil, ad is 10 the product obtaied by the trasesterificatio of pruus armeiaca (apricot) kerel oil ad polyglyceri-10 ski-coditioig aget - emolliet; surfactat emulsifyig aget Caprylic/Capric Glycerides Polyglyceryl-10 Esters Polyglyceryl-10 Apricot Kerelate Polyglyceryl-10 Beheate/Eicosadioate Polyglyceryl-10 Caprylate/Caprate wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from pruus armeiaca (apricot) kerel oil, ad is 10 the product obtaied by the trasesterificatio of caprylic/capric glycerides with polyglyceri-10 wherei C()- represets the residue of caprylic or capric acid, ad is 10 the ester of the fatty acids derived from pruus armeiaca (apricot) kerel oil ad polyglyceri-10 wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from pruus armeiaca (apricot) kerel oil, ad is 10 the mooester of polyglyceri-10 ad a bled of beheic ad eicosadioic acids wherei C()- represets the residue of beheic or eicosadioic acid, ad is 10 the mooester of polyglyceri-10 ad a bled of caprylic ad capric acids ski-coditioig aget - emolliet; surfactat emulsifyig aget; surfactat - solubilizig aget ski-coditioig aget - emolliet; ski-coditioig aget miscellaeous; surfactat - emulsifyig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget emulsio stabilizer; solvet; surfactat emulsifyig aget Polyglyceryl-10 Cocoate wherei C()- represets the residue of capric or caprylic acid, ad is 10 the ester of cocout acid ad polyglyceri-10 wherei C()- represets the residue of cocout acid, ad is 10 surfactatcleasig aget; surfactatemulsifyig aget

55 Distributed for Commet ly -- Do Not Cite or Quote 1 ( CI Staff) Table 3. Defiitios, idealized structures, ad fuctio Igrediet CAS No. Defiitio & Structure Fuctio(s) Polyglyceryl-10 Eicosaedioate/Tetradecaedioate the ester of polyglyceri-10 with a mixture of eicosaedioic ad tetradecaedioic acids hair coditioig aget; ski coditioig aget - occlusive Polyglyceryl-10 ydroxystearate/ Stearate/Eicosadioate wherei C()- represets the residue of eicosaedioic or tetradecaedioic acid, ad is 10 the mooester of polyglyceri-10 with a bled of hydroxystearic, stearic ad eicosadioic acids ski-coditioig aget - emolliet Polyglyceryl-10 Palmate Sclerocarya Birrea Seed il Polyglyceryl-10 Esters wherei C()- represets the residue of hydroxystearic, stearic ad eicosadioic acids, ad is 10 the ester of palm acid ad polyglyceri-10 wherei C()- represets the residue of palm acid, ad is 10 the product obtaied by the trasesterificatio of sclerocarya birrea seed oil with polyglyceri-10 ski-coditioig aget - misc; surfactat - emulsifyig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget Suflower Seed il Polyglyceryl-10 Esters wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from sclerocarya birrea seed oil, ad is 10 the product obtaied by the trasesterificatio of heliathus auus (suflower) seed oil ad polyglyceri-10 ski-coditioig aget - emolliet; surfactat - emulsifyig aget Watermelo Seed il Polyglyceryl-10 Esters wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from heliathus auus (suflower) seed oil, ad is 10 the product obtaied by the trasesterificatio of citrullus laatus (watermelo) seed oil with polyglyceri-10 ski-coditioig aget - emolliet; surfactat - emulsifyig aget Polyglyceryl-2 discrete multi-esters Polyglyceryl-2 Sesquicaprylate Polyglyceryl-2 Sesquiisostearate Polyglyceryl-2 Diisostearate (geeric) wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from citrullus laatus (watermelo) seed oil, ad is 10 Polyglyceryl Multi-esters (i.e., ot moo-esters ad ot polyesters ) a mixture of moo- ad diesters of caprylic acid ad diglyceri wherei - represets hydroge or the residue of caprylic acid, ad is 2 a mixture of moo ad diesters of isostearic acid ad diglyceri wherei - represets hydroge or the residue of isostearic acid, ad is 2 the diester of isostearic acid ad diglyceri wherei C()- represets the residue of isostearic acid, ad is 2 ski-coditioig aget - emolliet; surfactat - emulsifyig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget

56 Distributed for Commet ly -- Do Not Cite or Quote 1 ( CI Staff) Table 3. Defiitios, idealized structures, ad fuctio Igrediet CAS No. Defiitio & Structure Fuctio(s) Polyglyceryl-2 Triisostearate the triester of isostearic acid ad diglyceri ski-coditioig aget - emolliet; surfactat - emulsifyig aget Polyglyceryl-2 Tetraisostearate wherei - represets hydroge or the residue of isostearic acid, ad is 2 the tetraester of isostearic acid ad a dimer of glyceri ski-coditioig aget - emolliet; surfactat - emulsifyig aget Polyglyceryl-2 Dioleate Polyglyceryl-2 Sesquioleate Polyglyceryl-2 Tetraoleate wherei C()- represets the residue of isostearic acid, ad is 2 a diester of oleic acid ad diglyceri wherei C()- represets the residue of oleic acid, ad is 2 a mixture of moo ad diesters of oleic acid ad diglyceri wherei - represets hydroge or the residue of oleic acid, ad is 2 the tetraester of oleic acid ad diglyceri ski-coditioig aget - emolliet; surfactat - emulsifyig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget ski-coditioig aget - misc; surfactat - emulsifyig aget Polyglyceryl-2 Sesquistearate (geeric) Polyglyceryl-2 Distearate (geeric) wherei C()- represets the residue of oleic acid, ad is 2 a mixture of moo- ad diesters of stearic acid ad diglyceri wherei - represets hydroge or the residue of stearate acid, ad is 2 the diester of stearic acid ad diglyceri ski-coditioig aget - emolliet; surfactat - emulsifyig aget surfactat - emulsifyig aget Polyglyceryl-2 Tetrastearate (geeric) wherei C()- represets the residue of stearic acid, ad is 2 the tetraester of stearic acid ad diglyceri ski-coditioig aget - emolliet; surfactat - emulsifyig aget Polyglyceryl-2 mixed multi-esters Polyglyceryl-2 Tetrabeheate/ Macadamiate/Sebacate wherei C()- represets the residue of stearic acid, ad is 2 the tetraester of a mixture of beheic, sebacic ad macadamia acids with a dimer of glyceri ski-coditioig aget - emolliet Polyglyceryl-3 discrete multi-esters Polyglyceryl-3 Dicaprate wherei C()- represets the residue of beheic, sebacic, or macadamia acid, ad is 2 the diester of capric acid ad polyglyceri-3 wherei C()- represets the residue of capric acid, ad is 3 ski-coditioig aget - emolliet; surfactat - emulsifyig aget

57 Distributed for Commet ly -- Do Not Cite or Quote 1 ( CI Staff) Table 3. Defiitios, idealized structures, ad fuctio Igrediet CAS No. Defiitio & Structure Fuctio(s) Polyglyceryl-3 Diisostearate a diester of isostearic acid ad polyglyceri-3 ski-coditioig (geeric) aget - emolliet; surfactat - emulsifyig aget Polyglyceryl-3 Triisostearate Polyglyceryl-3 Dioleate Polyglyceryl-3 Distearate (geeric) (geeric) Polyglyceryl-3 Di-ydroxystearate Polyglyceryl-3 Petaricioleate wherei C()- represets the residue of isostearic acid, ad is 3 the triester of isostearic acid ad polyglyceri-3 wherei - represets hydroge or the residue of isostearic acid, ad is 3 a diester of oleic acid ad polyglyceri-3 wherei C()- represets the residue of oleic acid, ad is 3 the diester of stearic acid ad polyglyceri-3 wherei C()- represets the residue of stearic acid, ad is 3 the diester of hydroxystearic acid ad polyglyceri-3 wherei C()- represets the residue of hydroxystearic acid, ad is 3 the petaester of ricioleic acid ad polyglyceri-3 ski-coditioig aget - emolliet; surfactat - emulsifyig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget Polyglyceryl-3 mixed multi-esters Diisostearoyl Polyglyceryl-3 Dimer Dilioleate wherei C()- represets the residue of ricioleic acid, ad is 3 the diester of dilioleic acid ad Polyglyceryl-3 Diisostearate ski-coditioig aget - emolliet Polyglyceryl-3 Dicitrate/Stearate wherei - represets the residue of isostearic acid or dilioleic acid, ad is 3 the diester of polyglyceri-3 with a mixture of citric acid ad stearic acid surfactat - emulsifyig aget Polyglyceryl-3 Dicocoate Polyglyceryl-3 Petacaprylate/Caprate wherei C()- represets the residue of citric or stearic acid, ad is 3 the diester of cocout acid ad polyglyceri-3 wherei C()- represets the residue of cocout acid, ad is 3 the petaester of a mixture of caprylic acid ad capric acid with polyglyceri-3 wherei - represets hydroge or the residue of capric or caprylic acid, ad is 3 ski-coditioig aget - emolliet; surfactat - emulsifyig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget; surfactat solubilizig aget

58 Distributed for Commet ly -- Do Not Cite or Quote 1 ( CI Staff) Table 3. Defiitios, idealized structures, ad fuctio Igrediet CAS No. Defiitio & Structure Fuctio(s) Polyglyceryl-3 Petaolivate is the petaester of polyglyceri-3 ad olive acid ski-coditioig aget - emolliet; surfactat - emulsifyig aget Polyglyceryl-3 Triolivate wherei C()- represets the residue of olive acid, ad is 3 the triester of polyglyceri-3 ad olive acid surfactat - emulsifyig aget Triisostearoyl Polyglyceryl-3 Dimer Dilioleate wherei - represets hydroge or the residue of olive acid, ad is 3 the diester of dilioleic acid ad polyglyceryl-3 triisostearate ski-coditioig aget - emolliet Polyglyceryl-4 discrete multi-esters Polyglyceryl-4 Dilaurate Polyglyceryl-4 Petaoleate Polyglyceryl-4 Distearate wherei - represets the residue of isostearic acid or dilioleic acid, ad is 3 the diester of lauric acid ad polyglyceri-4 wherei C()- represets the residue of lauric acid, ad is 4 the petaester of oleic acid ad polyglyceri-4 wherei - represets hydroge or the residue of oleic acid, ad is 4 a diester of polyglyceri-4 with stearic acid ski-coditioig aget - emolliet; surfactat - emulsifyig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget surfactat - emulsifyig aget Polyglyceryl-4 Tristearate Polyglyceryl-4 Petastearate Polyglyceryl-4 mixed multi-esters Polyglyceryl-4 Petapalmitate/Stearate wherei C()- represets the residue of stearic acid, ad is 4 the triester of stearic acid ad polyglyceri-4 wherei - represets hydroge or the residue of stearic acid, ad is 4 the petaester of stearic acid ad polyglyceri-4 wherei - represets hydroge or the residue of stearic acid, ad is 4 the petaester of a mixture of palmitic acid ad stearic acid with polyglyceri- 4 ski-coditioig aget - emolliet; surfactat - emulsifyig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget surfactat - emulsifyig aget Pumpki Seed il Polyglyceryl-4 Esters wherei - represets hydroge or the residue of palmitic or stearic acid, ad is 4 the complex mixture of esters formed by the trasesterificatio of cucurbita pepo (pumpki) seed oil ad polyglyceri-4 emulsio stabilizer; surfactat - emulsifyig aget wherei - represets hydroge or the residue of the fatty acids derived from cucurbita pepo (pumpki) seed oil (via trasesterificatio), ad is 4

59 Distributed for Commet ly -- Do Not Cite or Quote 1 ( CI Staff) Table 3. Defiitios, idealized structures, ad fuctio Igrediet CAS No. Defiitio & Structure Fuctio(s) Pumpki Seed il Polyglyceryl-4 Esters Succiate the complex mixture of esters formed by the trasesterificatio of cucurbita pepo (pumpki) seed oil ad polyglyceri-4 reacted with succiic acid emulsio stabilizer; surfactat - emulsifyig aget Polyglyceryl-5 discrete multi-esters Polyglyceryl-5 Dicaprylate (geeric) Polyglyceryl-5 Dilaurate wherei - represets hydroge or the residue of succiic acid or the fatty acids derived from cucurbita pepo (pumpki) seed oil (via trasesterificatio), ad is 4 the diester of caprylic acid with a glyceri polymer cotaiig 5 glyceri uits wherei C()- represets the residue of caprylic acid, ad is 5 the diester of lauric acid ad a glyceri polymer cotaiig 5 uits of glyceri ski-coditioig aget - emolliet; surfactat cleasig aget; surfactat - emulsifyig aget surfactat - emulsifyig aget Polyglyceryl-5 Trimyristate Polyglyceryl-5 Petamyristate Polyglyceryl-5 Triisostearate Polyglyceryl-5 Dioleate wherei C()- represets the residue of lauric acid, ad is 5 the triester of myristic acid ad a glyceri polymer cotaiig 5 uits of glyceri wherei - represets hydroge or the residue of myristic acid, ad is 5 the petaester of myristic acid ad a glyceri polymer cotaiig 5 uits of glyceri wherei - represets hydroge or the residue of myristic acid, ad is 5 the triester of isostearic acid ad a glyceri polymer cotaiig 5 uits of glyceri wherei - represets hydroge or the residue of isostearic acid, ad is 5 the diester of oleic acid ad a glyceri polymer cotaiig 5 uits of glyceri ski-coditioig aget - emolliet; surfactat - emulsifyig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget surfactat cleasig aget; surfactat dispersig aget; surfactat - emulsifyig aget surfactat - emulsifyig aget Polyglyceryl-5 Trioleate Polyglyceryl-5 Tristearate (geeric) Polyglyceryl-5 exastearate wherei C()- represets the residue of oleic acid, ad is 5 the triester of oleic acid ad a glyceri polymer cotaiig 5 uits of glyceri wherei - represets hydroge or the residue of oleic acid, ad is 5 the triester of stearic acid ad a glyceri polymer cotaiig 5 uits of glyceri wherei - represets hydroge or the residue of stearic acid, ad is 5 the hexaester of stearic acid ad a glyceri polymer cotaiig 5 uits of glyceri wherei - represets hydroge or the residue of stearic acid, ad is 5 ski-coditioig aget - emolliet; surfactat - emulsifyig aget surfactat cleasig aget; surfactat dispersig aget; surfactat - emulsifyig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget

60 Distributed for Commet ly -- Do Not Cite or Quote 1 ( CI Staff) Table 3. Defiitios, idealized structures, ad fuctio Igrediet CAS No. Defiitio & Structure Fuctio(s) Polyglyceryl-5 Tribeheate the triester of beheic acid ad a glyceri polymer cotaiig 5 uits of glyceri ski-coditioig aget - emolliet; surfactat - emulsifyig aget Polyglyceryl-6 discrete multi-esters Polyglyceryl-6 Sesquicaprylate (geeric) (geeric) (geeric) Polyglyceryl-6 Dicaprate Polyglyceryl-6 Tricaprylate wherei - represets hydroge or the residue of beheic acid, ad is 5 a mixture of moo- ad diesters of caprylic acid ad polyglyceri-6 wherei - represets hydroge or the residue of caprylic acid, ad is 6 the diester of capric acid ad polyglyceri-6 wherei C()- represets the residue of capric acid, ad is 6 the triester of caprylic acid ad polyglyceri-6 ski-coditioig aget - emolliet; surfactat cleasig aget; surfactat - emulsifyig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget surfactat cleasig aget Polyglyceryl-6 Tetracaprylate wherei - represets hydroge or the residue of caprylic acid, ad is 6 the tetraester of caprylic acid ad polyglyceri-6 surfactat cleasig aget Polyglyceryl-6 Petacaprylate wherei - represets hydroge or the residue of caprylic acid, ad is 6 the petaester of caprylic acid ad polyglyceri-6 surfactat cleasig aget Polyglyceryl-6 eptacaprylate wherei - represets hydroge or the residue of caprylic acid, ad is 6 the heptaester of caprylic acid ad polyglyceri-6 surfactat - emulsifyig aget Polyglyceryl-6 ctacaprylate wherei - represets hydroge or the residue of caprylic acid, ad is 6 the octaester of polyglyceri-6 ad caprylic acid ski-coditioig aget - emolliet Polyglyceryl-6 Dipalmitate Polyglyceryl-6 Sesquiisostearate wherei C()- represets the residue of caprylic acid, ad is 6 the diester of palmitic acid ad polyglyceri-6 wherei C()- represets the residue of palmitic acid, ad is 6 a mixture of moo- ad diesters of isostearic acid ad polyglyceri-6 ski-coditioig aget - emolliet; surfactat - emulsifyig aget surfactat - emulsifyig aget Polyglyceryl-6 Diisostearate wherei - represets hydroge or the residue of isostearic acid, ad is 6 the diester of isostearic acid ad polyglyceri-6 wherei C()- represets the residue of isostearic acid, ad is 6 ski-coditioig aget - emolliet; surfactat - emulsifyig aget

61 Distributed for Commet ly -- Do Not Cite or Quote 1 ( CI Staff) Table 3. Defiitios, idealized structures, ad fuctio Igrediet CAS No. Defiitio & Structure Fuctio(s) Polyglyceryl-6 Dioleate a diester of oleic acid ad polyglyceri-6 ski-coditioig aget - emolliet; surfactat - emulsifyig aget Polyglyceryl-6 Tetraoleate Polyglyceryl-6 Petaoleate Polyglyceryl-6 exaoleate Polyglyceryl-6 Sesquistearate wherei C()- represets the residue of oleic acid, ad is 6 the tetraester of leic Acid ad polyglyceri-6 wherei - represets hydroge or the residue of oleic acid, ad is 6 the petaester of oleic acid ad polyglyceri-6 wherei - represets hydroge or the residue of oleic acid, ad is 6 a hexaester of oleic acid ad polyglyceri-6 wherei - represets hydroge or the residue of oleic acid, ad is 6 a mixture of moo- ad diesters of stearic acid ad polyglyceri-6 ski-coditioig aget - emolliet; surfactat - emulsifyig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget surfactat - emulsifyig aget Polyglyceryl-6 Distearate (geeric) Polyglyceryl-6 Tristearate (geeric) Polyglyceryl-6 Petastearate (geeric) Polyglyceryl-6 exastearate Polyglyceryl-6 ctastearate wherei - represets hydroge or the residue of stearic acid, ad is 6 a diester of stearic acid ad polyglyceri-6 wherei C()- represets the residue of stearic acid, ad is 6 the triester of stearic acid ad polyglyceri-6 wherei - represets hydroge or the residue of stearic acid, ad is 6 the petaester of stearic acid ad polyglyceri-6 wherei - represets hydroge or the residue of stearic acid, ad is 6 the hexaester of stearic acid ad polyglyceri-6 wherei - represets hydroge or the residue of stearic acid, ad is 6 the octaester of stearic acid ad polyglyceri-6 ski-coditioig aget - emolliet; surfactat - emulsifyig aget surfactat - emulsifyig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget Polyglyceryl-6 Petaricioleate Polyglyceryl-6 Tetrabeheate wherei C()- represets the residue of stearic acid, ad is 6 the petaester of ricioleic acid ad polyglyceri-6 wherei - represets hydroge or the residue of ricioleic acid, ad is 6 the tetraester of beheic acid ad polyglyceri-6 wherei - represets hydroge or the residue of beheic acid, ad is 6 ski-coditioig aget - emolliet; surfactat - emulsifyig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget

62 Distributed for Commet ly -- Do Not Cite or Quote 1 ( CI Staff) Table 3. Defiitios, idealized structures, ad fuctio Igrediet CAS No. Defiitio & Structure Fuctio(s) Polyglyceryl-6 mixed multi-ester Macadamia Seed il Polyglyceryl-6 Esters Beheate the beheic acid ester of the product obtaied by the trasesterificatio of macadamia seed oil ad polyglyceri-6 ski-coditioig aget - emolliet Polyglyceryl-8 mixed multi-esters Polyglyceryl-8 Decabeheate/Caprate 3C 20 wherei C()- represets the residue of fatty acids derived (via trasesterificatio) from macadamia terifolia seed oil, ad is 6 the decaester of a mixture of beheic acid ad capric acid with a glyceri polymer cotaiig 8 uits of glyceri viscosity icreasig aget - oaqueous Polyglyceryl-8 Decaerucate/Decaisostearate/ Decaricioleate wherei C()- represets the residue of capric or beheic acid, ad is 8 the decaester of a glyceri polymer cotaiig 8 uits of glyceri with a mixture of erucic acid, isostearic acid ad ricioleic acid ski-coditioig aget - emolliet Polyglyceryl-10 discrete multi-esters Polyglyceryl-10 Decaethylhexaoate wherei C()- represets the residue of erucic, isostearic, or ricioleic acid, ad is 8 the decaester of 2-ethylhexaoic acid ad polyglyceri-10 ski coditioig aget - humectat Polyglyceryl-10 Dodecacaprate wherei C()- represets the residue of 2-ethylhexaoic acid, ad is 10 the dodecaester of capric acid ad polyglyceri-10 ski-coditioig aget - emolliet; surfactat - emulsifyig aget Polyglyceryl-10 Petacaprylate Polyglyceryl-10 Dodecacaprylate wherei C()- represets the residue of capric acid, ad is 10 the petaester of caprylic acid ad polyglyceri-10 wherei - represets hydroge or the residue of caprylic acid, ad is 10 the dodecaester of caprylic acid ad polyglyceri-10 surfactat cleasig aget; surfactat - emulsifyig aget; surfactat solubilizig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget Polyglyceryl-10 Tridecaoate Polyglyceryl-10 Dilaurate wherei C()- represets the residue of caprylic acid, ad is 10 the triester of decaoic acid ad polyglyceri-10 wherei - represets hydroge or the residue of decaoic acid, ad is 10 the diester of lauric acid ad polyglyceri-10 ski-coditioig aget - emolliet; surfactat - emulsifyig aget surfactat cleasig aget wherei C()- represets the residue of lauric acid, ad is 10

63 Distributed for Commet ly -- Do Not Cite or Quote 1 ( CI Staff) Table 3. Defiitios, idealized structures, ad fuctio Igrediet CAS No. Defiitio & Structure Fuctio(s) Polyglyceryl-10 Trilaurate the triester of lauric acid ad polyglyceri-10 surfactat cleasig aget Polyglyceryl-10 Tetralaurate wherei - represets hydroge or the residue of lauric acid, ad is 10 the tetraester of lauric acid ad polyglyceri-10 surfactat cleasig aget Polyglyceryl-10 Petalaurate Polyglyceryl-10 Dimyristate wherei - represets hydroge or the residue of lauric acid, ad is 10 the petaester of lauric acid ad polyglyceri-10 wherei - represets hydroge or the residue of lauric acid, ad is 10 the diester of myristic acid ad polyglyceri-10 ski-coditioig aget - emolliet; surfactat - emulsifyig aget surfactat - emulsifyig aget Polyglyceryl-10 Dipalmitate Polyglyceryl-10 Diisostearate (geeric) Polyglyceryl-10 Triisostearate wherei C()- represets the residue of myristic acid, ad is 10 the diester of palmitic acid ad polyglyceri-10 wherei C()- represets the residue of palmitic acid, ad is 10 a diester of isostearic acid ad polyglyceri-10 wherei C()- represets the residue of isostearic acid, ad is 10 the triester of polyglyceri-10 ad isostearic acid ski-coditioig aget - emolliet; surfactat - emulsifyig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget surfactat - emulsifyig aget Polyglyceryl-10 Petaisostearate Polyglyceryl-10 exaisostearate Polyglyceryl-10 Noaisostearate wherei - represets hydroge or the residue of isostearic acid, ad is 10 the petaester of isostearic acid ad polyglyceri-10 wherei - represets hydroge or the residue of isostearic acid, ad is 10 the hexaester of polyglyceri-10 ad isostearic acid wherei - represets hydroge or the residue of isostearic acid, ad is 10 the oaester of polyglyceri-10 ad isostearic acid ski-coditioig aget - emolliet; surfactat - emulsifyig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget ski-coditioig aget - emolliet Polyglyceryl-10 Decaisostearate wherei - represets hydroge or the residue of isostearic acid, ad is 10 the ester of polyglyceri-10 ad isostearic acid ski-coditioig aget - emolliet Polyglyceryl-10 Petalioleate wherei C()- represets the residue of isostearic acid, ad is 10 the petaester of lioleic acid ad polyglyceri-10 wherei - represets hydroge or the residue of lioleic acid, ad is 10 ski-coditioig aget - emolliet; surfactat - emulsifyig aget

64 Distributed for Commet ly -- Do Not Cite or Quote 1 ( CI Staff) Table 3. Defiitios, idealized structures, ad fuctio Igrediet CAS No. Defiitio & Structure Fuctio(s) Polyglyceryl-10 Decalioleate a decaester of lioleic acid ad polyglyceri-10 ski-coditioig aget - emolliet; surfactat - emulsifyig aget Polyglyceryl-10 Dioleate Polyglyceryl-10 Trioleate wherei C()- represets the residue of lioleic acid, ad is 10 a diester of oleic acid ad polyglyceri-10 wherei C()- represets the residue of oleic acid, ad is 10 the triester of oleic acid ad polyglyceri-10 ski-coditioig aget - emolliet; surfactat - emulsifyig aget surfactat - emulsifyig aget Polyglyceryl-10 Tetraoleate Polyglyceryl-10 Petaoleate Polyglyceryl-10 Petaricioleate Polyglyceryl-10 exaoleate Polyglyceryl-10 eptaoleate Polyglyceryl-10 Decaoleate wherei - represets hydroge or the residue of oleic acid, ad is 10 a tetraester of oleic acid ad polyglyceri-10 wherei - represets hydroge or the residue of oleic acid, ad is 10 the petaester of oleic acid ad polyglyceri-10 wherei - represets hydroge or the residue of oleic acid, ad is 10 the petaester of ricioleic acid ad polyglyceri-10 wherei - represets hydroge or the residue of ricioleic acid, ad is 10 the hexaester of oleic acid ad polyglyceri-10 wherei - represets hydroge or the residue of oleic acid, ad is 10 a heptaester of oleic acid ad polyglyceri-10 wherei - represets hydroge or the residue of oleic acid, ad is 10 a decaester of oleic acid ad polyglyceri-10 ski-coditioig aget - emolliet; surfactat - emulsifyig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget Polyglyceryl-10 Distearate (geeric) Polyglyceryl-10 Tristearate (geeric) wherei C()- represets the residue of oleic acid, ad is 10 the diester of stearic acid ad polyglyceri-10 wherei C()- represets the residue of stearic acid, ad is 10 the triester of stearic acid ad polyglyceri-10 wherei - represets hydroge or the residue of stearic acid, ad is 10 ski-coditioig aget - emolliet; surfactat - emulsifyig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget

65 Distributed for Commet ly -- Do Not Cite or Quote 1 ( CI Staff) Table 3. Defiitios, idealized structures, ad fuctio Igrediet CAS No. Defiitio & Structure Fuctio(s) Polyglyceryl-10 Petastearate a petaester of stearic acid ad polyglyceri-10 ski-coditioig (geeric) aget - emolliet; surfactat - emulsifyig aget Polyglyceryl-10 Petahydroxystearate Polyglyceryl-10 eptahydroxystearate Polyglyceryl-10 eptastearate (geeric) Polyglyceryl-10 Decahydroxystearate wherei - represets hydroge or the residue of stearic acid, ad is 10 the petaester of hydroxystearic acid ad polyglyceri-10 wherei - represets hydroge or the residue of hydroxystearic acid, ad is 10 a heptaester of hydroxystearic acid ad polyglyceri-10 wherei - represets hydroge or the residue of hydroxystearic acid, ad is 10 the heptaester of stearic acid ad polyglyceri-10 wherei - represets hydroge or the residue of stearic acid, ad is 10 the decaester of hydroxystearic acid ad polyglyceri-10 ski-coditioig aget - emolliet; surfactat - emulsifyig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget Polyglyceryl-10 Decastearate wherei C()- represets the residue of hydroxystearic acid, ad is 10 a decaester of stearic acid ad polyglyceri-10 ski-coditioig aget - emolliet; surfactat - emulsifyig aget Polyglyceryl-10 Dodecabeheate wherei C()- represets the residue of stearic acid, ad is 10 the dodecaester of beheic acid ad polyglyceri-10 surfactat - emulsifyig aget Polyglyceryl-10 Trierucate Polyglyceryl-10 exaerucate Polyglyceryl-10 Noaerucate wherei C()- represets the residue of beheic, ad is 10 the triester of polyglyceri-10 ad erucic acid wherei - represets hydroge or the residue of erucic acid, ad is 10 the hexaester of polyglyceri-10 ad erucic acid wherei - represets hydroge or the residue of erucic acid, ad is 10 the oaester of erucic acid ad polyglyceri-10 wherei - represets hydroge or the residue of erucic acid, ad is 10 surfactat dispersig aget; surfactat - emulsifyig aget surfactat dispersig aget; surfactat - emulsifyig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget

66 Distributed for Commet ly -- Do Not Cite or Quote 1 ( CI Staff) Table 3. Defiitios, idealized structures, ad fuctio Igrediet CAS No. Defiitio & Structure Fuctio(s) Polyglyceryl-10 mixed multi-esters Polyglyceryl-10 Decamacadamiate a decaester of polyglyceri-10 ad the fatty acids derived from macadamia ut oil ski-coditioig aget - emolliet; surfactat - emulsifyig aget Polyglyceryl-10 Dicocoate Polyglyceryl-10 Didecaoate Polyglyceryl-10 Dodeca-Caprylate/ Caprate wherei C()- represets the residue of the fatty acids derived from macadamia ut oil, ad is 10 the diester of cocout acid ad polyglyceri-10 wherei C()- represets the residue of cocout acid, ad is 10 the diester of decaoic acid adppolyglyceri-10 wherei C()- represets the residue of decaoic acid, ad is 10 the dodecaester of a mixture of caprylic ad capric acids with polyglyceri-10 surfactat cleasig aget; surfactat - emulsifyig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget ski-coditioig aget - occlusive Polyglyceryl-10 epta(beheate/stearate) wherei C()- represets the residue of capric or caprylic acid, ad is 10 the heptaester of polyglyceri-10 with a mixture of beheic acid ad stearic acid surfactat - emulsifyig aget Polyglyceryl-10 Moo/Dioleate Polyglyceryl-10 Sesquistearate wherei - represets hydroge or the residue of beheic acid ad stearic acid, ad is 10 a mixture of moo- ad diesters of oleic acid ad polyglyceri-10 wherei - represets hydroge or the residue of oleic acid, ad is 10 a mixture of moo- ad diesters of stearic acid ad polyglyceri-10 ski-coditioig aget - emolliet; surfactat - emulsifyig aget surfactat - emulsifyig aget Polyglyceryl-10 Tetradecaedioate Polyglyceryl-10 Tricocoate Polyglyceryl-15 discrete multi-ester Polyglyceryl-15 Diisostearate wherei - represets hydroge or the residue of stearate acid, ad is 10 the ester of tetradecaedioic acid ad polyglyceri-10 wherei - represets hydroge or the residue of tetradecaedioic acid, ad is 10 the triester of cocout acid ad polyglyceri-10 wherei - represets hydroge or the residue of cocout acid, ad is 10 a diester of isostearic acid ad a glyceri polymer cotaiig 15 glyceri uits wherei C()- represets the residue of isostearic acid, ad is 15 hair coditioig aget; ski coditioig aget - humectat surfactat cleasig aget; surfactat - emulsifyig aget hair coditioig aget; surfactat cleasig aget; surfactat - emulsifyig aget

67 Distributed for Commet ly -- Do Not Cite or Quote 1 ( CI Staff) Table 3. Defiitios, idealized structures, ad fuctio Igrediet CAS No. Defiitio & Structure Fuctio(s) Polyglyceryl-20 discrete multi-esters Polyglyceryl-20 exacaprylate the hexaester of caprylic acid ad polyglyceri-20 Polyglyceryl-20 eptacaprylate Polyglyceryl-20 ctaisooaoate Polyglyceryl-20 mixed multi-esters Polyglyceryl-20 Docosabeheate/Isostearate wherei - represets hydroge or the residue of caprylic acid, ad is 20 the heptaester of caprylic acid ad polyglyceri-20 wherei - represets hydroge or the residue of caprylic acid, ad is 20 the octaester of isooaoic acid ad polyglyceri-20 wherei - represets hydroge or the residue of isooaoic acid, ad is 20 the docosaester of polyglyceri-20 with a mixture of beheic ad isostearic acids surfactat cleasig aget; surfactat - emulsifyig aget; surfactat solubilizig aget surfactat cleasig aget; surfactat - emulsifyig aget; surfactat solubilizig aget surfactat cleasig aget; surfactat - emulsifyig aget; surfactat solubilizig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget Polyglyceryl-20 Docosabeheate/Laurate wherei C()- represets the residue of beheic or isostearic acid, ad is 20 the docosaester of polyglyceri-20 with a mixture of beheic ad lauric acids ski-coditioig aget - emolliet; surfactat - emulsifyig aget Polyglyceryl-20 Docosabeheate/leate wherei C()- represets the residue of beheic or lauric acid, ad is 20 the docosaester of polyglyceri-20 with a mixture of beheic ad oleic acids ski-coditioig aget - emolliet; surfactat - emulsifyig aget Polyglyceryl-20 eptadecabeheate/laurate Polyglyceryl-20 ctadecabeheate/laurate wherei C()- represets the residue of beheic or oleic acid, ad is 20 the heptadecaester of polyglyceri-20 with a mixture of beheic ad lauric acids wherei - represets hydroge or the residue of beheic or lauric acid, ad is 20 the octadecaester of polyglyceri-20 ad a mixture of beheic ad lauric acids wherei - represets hydroge or the residue of beheic or lauric acid, ad is 20 ski-coditioig aget - emolliet; surfactat - emulsifyig aget ski-coditioig aget - emolliet; surfactat - emulsifyig aget

68 Distributed for Commet ly -- Do Not Cite or Quote Table 4. Previously eviewed Compoets ad elated Igrediets Compoet Coclusio eferece Glyceri safe i cosmetics i the preset practices of use ad cocetratio (was used i 15,654 formulatios, 10,046 of which were leave-os; the maximum use cocetratios were 79.2% i leave-o products, 99.4% i rise-off products, ad 47.9% i products diluted for the bath 69 Dipropylee Glycol Tripropylee Glycol Polypropylee Glycols (ad PPG 3) Mooglyceryl Mooesters Glyceryl Algiate Glyceryl Isostearate/Myristate Glyceryl Myristate Citric Acid Cocout Acid ydroxystearic Acid Isostearic Acid Lauric Acid Myristic Acid leic Acid live Acid Palm Acid Palmitic Acid ice Bra Acid icioleic Acid Sebacic Acid Stearic Acid Potassium Stearate Sodium Stearate Acacia Decurres Flower Wax this wax has ot be bee reviewed, but Acacia Decurres ad Acacia Faresiaa Flower Wax have bee reviewed Adasoia Digitata Seed il Argaia Spiosa Kerel il Beeswax Bertholletia Excelsa Seed il Borago fficialis Seed il Butyrospermum Parkii (Shea) Butter Caprylic/Capric/Coco Glycerides Carthamus Tictorius (Safflower) Seed il Citrullus Laatus (Watermelo) Seed il Cocos Nucifera (Cocout) il Cocoglycerides ydrogeated Coco-Glycerides Corylus Avellaa (azelut) Seed il Cucurbita Pepo (Pumpki) Seed il Elaeis Guieesis (Palm) il Elaeis Guieesis (Palm) Kerel il Euphorbia Cerifera (Cadelilla) Wax Glycie Soja (Soybea) il ydrogeated Soybea il eliathus Auus (Suflower) Seed il eliathus Auus (Suflower) Seed Wax Lium Usitatissimum (Liseed) Seed il Macadamia Itegrifolia Seed il Macadamia Terifolia Seed il lea Europaea (live) Fruit il rbigya leifera Seed il ryza Sativa (ice) Bra il ryza Sativa (ice) Bra Wax safe as used safe i the preset practices of use ad cocetratio whe formulated to be o-irritatig safe i the preset practices of use ad cocetratio whe formulated to be o-irritatig safe i the preset practices of use ad cocetratio safe i the preset practices of use ad cocetratio safe i the preset practices of use ad cocetratio safe i the preset practices of use ad cocetratio safe for use as a cosmetic igrediet safe as a cosmetic igrediet i the preset practices of use safe as a cosmetic igrediet i the preset practices of use safe i the preset practices of use ad cocetratio safe i the preset practices of use ad cocetratio safe i the preset practices of use ad cocetratio safe i the preset practices of use ad cocetratio safe i the preset practices of use ad cocetratio safe i the preset practices of use ad cocetratio safe i the preset practices of use ad cocetratio safe i the preset practices of use ad cocetratio safe i the preset practices of use ad cocetratio safe i the preset practices of use ad cocetratio data were isufficiet to support the safety of Acacia Decurres ad Acacia Faresiaa Flower Wax i cosmetic products safe i the preset practices of use ad cocetratio safe i the preset practices of use ad cocetratio safe i the preset practices of use ad cocetratio safe i the preset practices of use ad cocetratio safe i the preset practices of use ad cocetratio safe i the preset practices of use ad cocetratio safe for use as a cosmetic igrediet safe i the preset practices of use ad cocetratio safe i the preset practices of use ad cocetratio safe for use as a cosmetic igrediet safe i the preset practices of use ad cocetratio safe i the preset practices of use ad cocetratio safe i the preset practices of use ad cocetratio safe i the preset practices of use ad cocetratio safe i the preset practices of use ad cocetratio safe i the preset practices of use ad cocetratio safe i the preset practices of use ad cocetratio safe i the preset practices of use ad cocetratio safe i the preset practices of use ad cocetratio safe i the preset practices of use ad cocetratio 70, ,84 83, , ,

69 Distributed for Commet ly -- Do Not Cite or Quote Table 4. Previously eviewed Compoets ad elated Igrediets Compoet Coclusio eferece Persea Gratissima (Avocado) il safe i the preset practices of use ad cocetratio 80 Pruus Amygdalus Dulcis (Sweet Almod) il safe i the preset practices of use ad cocetratio 80 Pruus Armeiaca (Apricot) Kerel il safe i the preset practices of use ad cocetratio 80 icius Commuis (Castor) Seed il safe i the preset practices of use ad cocetratio 81 ydrogeated Castor il Schiziophyto autaeii Kerel il safe i the preset practices of use ad cocetratio 80 Sclerocarya Birrea Seed il safe i the preset practices of use ad cocetratio 80 Simmodsia Chiesis (Jojoba) Seed Wax safe i the preset practices of use ad cocetratio 89 Sesamum Idicum (Sesame) Seed il safe i the preset practices of use ad cocetratio 80 Theobroma Cacao (Cocoa) Seed Butter safe i the preset practices of use ad cocetratio 80 Theobroma Gradiflorum Seed Butter safe i the preset practices of use ad cocetratio 80

70 Distributed for Commet ly -- Do Not Cite or Quote Table 5. Average fatty acid compositio of polyglyceryl fatty acid esters (%) Adasoia Digitata Apricot Kerel il Seed il Polyglyceryl- Polyglyceryl-6 Esters 91 Fatty Acids 6 Esters 90 Apricot Kerel il Polyglyceryl-10 Esters 92 Arga il Polyglyceryl-6 Esters 93,93 Babassu il Polyglyceryl-6 Esters 94 Bertholletia Excelsa Seed il Polyglyceryl- 6 Esters 95 Caprylic/Capric Glycerides Polyglyceryl-10 Esters 96 Caproic (C6) <2 Caprylic (C8) Capric (C10) Lauric (C12) * <3 Myristic (C14) <1 Myristoleic (C14:1) Palmitic (C16) Palmitoleic (C16:1) <1.5 eptadecaoic (C17:0) Stearic (C18) leic (C18:1) Lioleic (C18:2) Lioleic (C18:3) 1-3 <0.5 <1 Arachidic (C20) < 2 <1.0 <1 <1 Eicoseoic (C20:1) <1.0 <1 Beheic (C22) Erucic (C22:1) Ligoceric (C24) thers Cocoa Butter Polyglyceryl-6 Esters 97 Cocout oil Polyglyceryl-6 Esters 98 azelut Seed il Polyglyceryl-6 Esters 99 Macadamia Seed il Polyglyceryl 6 Esters 100 live il Polyglyceryl-6 Esters 101 Polyglyceryl-10 Decaoleate 32 Safflower Seed il Polyglyceryl-6 Esters 102 Caproic (C6) <1 Caprylic (C8) 4-10 Capric (C10) 4-11 Lauric (C12) * Myristic (C14) Myristoleic (C14:1) Palmitic (C16) Palmitoleic (C16:1) < <3.5 eptadecaoic (C17:0) Stearic (C18) leic (C18:1) Lioleic (C18:2) Lioleic (C18:3) <0.5 <0.6 <1.5 <0.2 Arachidic (C20) <1 Eicoseoic (C20:1) 1-3 <1 Beheic (C22) Erucic (C22:1) Ligoceric (C24) thers Total fatty acids are 83.1%

71 Distributed for Commet ly -- Do Not Cite or Quote Table 5. Average fatty acid compositio of polyglyceryl fatty acid esters (%) Schiziophyto Sclerocarya Birrea autaeii Kerel il Seed il Polyglyceryl- Polyglyceryl-6 6 Esters 104 Fatty Acids Esters 103 Sesame il Polyglyceryl-6 Esters 105 Shea Butter Polyglyceryl-6 Esters 106 Soybea il Polyglyceryl-6 Esters 107 Suflower Seed il Polyglyceryl-6 Esters (high oleic acid) 108 Suflower Seed il Polyglyceryl-10 Esters 109 Caproic (C6) Caprylic (C8) Capric (C10) Lauric (C12) * Myristic (C14) <0.2 Myristoleic (C14:1) Palmitic (C16) Palmitoleic (C16:1) <0.2 eptadecaoic (C17:0) Stearic (C18) leic (C18:1) Lioleic (C18:2) Lioleic (C18:3) <0.7 <1.1 < <1 <0.2 Arachidic (C20) <1 <1.2 <2.5 <1 Eicoseoic (C20:1) <0.5 <0.5 Beheic (C22) <1 Erucic (C22:1) Ligoceric (C24) <1 thers Sweet Almod il Polyglyceryl-6 Esters 110 Trichilia Emetica Seed il Polyglyceryl-6 Esters 111 Caproic (C6) Caprylic (C8) Capric (C10) Lauric (C12) * Myristic (C14) Myristoleic (C14:1) Palmitic (C16) Palmitoleic (C16:1) eptadecaoic (C17:0) <1 Stearic (C18) < leic (C18:1) Lioleic (C18:2) 8-13 Lioleic (C18:3) <1.5 Arachidic (C20) <1 Eicoseoic (C20:1) Beheic (C22) Erucic (C22:1) Ligoceric (C24) thers

72 Distributed for Commet ly -- Do Not Cite or Quote Table 6. Physical ad Chemical Properties Adasoia Digitata Seed il Polyglyceryl-6 Esters 90 Property physical characteristics soft paste amber i color Apricot Kerel il Polyglyceryl-6 Esters 91 amber liquid (20ºC) Apricot Kerel il Polyglyceryl-10 Esters 92 amber (physical state ot specified) Arga il Polyglyceryl-6 Esters 93,93 amber liquid Babassu il Polyglyceryl-6 Esters 94 soft paste with amber color Bertholletia Excelsa Seed il Polyglyceryl-6 Esters 95 soft paste with amber color Borage Seed il Polyglyceryl-6 Esters 112 molecular wt solubility water dispersible water dispersible water soluble water dispersible water dispersible water dispersible water dispersible meltig poit ( C) desity (g/ml) <1 <1 >1 <1 <1 specific gravity (g/ml) p refractive idex (20ºC) approx approx approx approx approx approx sapoificatio value acid value (mg K/g) < 5 <5 <5 <5 <5 < 5 hydroxyl value (mg K/g) peroxide value (meq of active oxyge/kg) <10 <10 <10 <10 <10 <10 iodie value (gi 2/100g) polarity o-ioic, amphiphilic o-ioic, amphiphilic o-ioic, amphiphilic o-ioic, amphiphilic o-ioic, amphiphilic o-ioic, amphiphilic o-ioic, amphiphilic LB Caprylic/Capric Glycerides Polyglyceryl-10 Esters 96 Cocoa Butter Polyglyceryl-6 Esters 97 Cocout il Polyglyceryl-6 Esters 98 Diisostearoyl Polyglyceryl-3 Dimer Dilioleate azelut Seed il Polyglyceryl-6 Esters 99 Macadamia Seed il Polyglyceryl-6 Esters 100 oil live il Polyglyceryl-6 Esters 101 amber amber liquid amber liquid physical characteristics amber i color beige solid soft paste, with amber viscous liquid 113 color yellow liquid 114 molecular wt ~6000 solubility water dispersible water dispersible water dispersible water dispersible water dispersible meltig poit ( C) desity (g/ml) >1 <1 <1 <1 <1 <1 specific gravity (g/ml) p refractive idex (20ºC) approx approx approx approx ~1.47 ~1.47 sapoificatio value acid value (mg K/g) <5 < 5 < max 113 <5 <5 <5 hydroxyl value (mg K/g) peroxide value (meq of active oxyge/kg) <10 <10 <10 <10 <10 <10 iodie value (gi 2/100g) max polarity o-ioic, amphiphilic o-ioic, amphiphilic o-ioic, amphiphilic o-ioic, amphiphilic o-ioic, amphiphilic o-ioic, amphiphilic LB ~5 114

73 Distributed for Commet ly -- Do Not Cite or Quote Table 6. Physical ad Chemical Properties Palm Kerel il Polyglyceryl-4 Esters 115 Polyglyceryl-3 Beeswax 116 Polyglyceryl-2 Caprate 117 Polyglyceryl-4 Caprate Polyglyceryl-3 Caprylate 118 Polyglyceryl-10 Caprylate/Caprate 24,119 Polyglyceryl-10 Decaisostearate 120 physical characteristics white to off-white trasparet, pale, yellow liquid with fait odor 121 high viscosity liquid amber, viscous liquid fait yellow liquid colorless to yellow, clear to slightly turbid, viscous liquid 122 molecular wt solubility water- ad oil- soluble soluble i water, ethaol, 1,2-propaediol, esters oil; isoluble i paraffi oi, isopropyl myristate, vegetable oil 122 meltig poit ( C) desity (g/ml) g/cm 3 specific gravity (g/ml) p refractive idex (20ºC) sapoificatio value acid value (mg K/g) 2 max 5 max max hydroxyl value (mg K/g) peroxide value (meq of active oxyge/kg) iodie value (gi 2/100g) polarity LB 5.0 max 2.0 max ; 14 ~ isoluble i water (25 C)

74 Distributed for Commet ly -- Do Not Cite or Quote Table 6. Physical ad Chemical Properties Polyglyceryl-10 Decaoleate Polyglyceryl-3 Di- ydroxystearate Polyglyceryl-2 Diisostearate Polyglyceryl-3 Diisostearate) 34 Polyglyceryl-6 Diisostearate 123 Polyglyceryl-3 Dioleate 26,124 Polyglyceryl-6 Dioleate 125 physical characteristics solid clear pale yellow, slightly yellowish, viscous pale yellow liquid viscous yellow liquid homogeous liquid 33 liquid molecular wt solubility slightly soluble i water < 0.15 mg/l (water) dispersible i water; soluble i may orgaic solvets meltig poit ( C) desity (g/ml) g/cm³ 33 specific gravity (g/ml) 0.99 p refractive idex (20ºC) (predicted) sapoificatio value ; acid value (mg K/g) hydroxyl value (mg ; K/g) peroxide value (meq of active oxyge/kg) iodie value (gi 2/100g) polarity LB 1.4 (predicted) 8 3

75 Distributed for Commet ly -- Do Not Cite or Quote Table 6. Physical ad Chemical Properties Polyglyceryl-10 Dipalmitate 127,127 Polyglyceryl-3 Distearate 128 Polyglyceryl-6 Distearate Polyglyceryl-10 Distearate 129 Polyglyceryl-2 Isopalmitate/Sebacate Polyglyceryl-2 Isostearate 131 Polyglyceryl-4 Isostearate 132 physical characteristics beads or waxy solids white or slightly yellowish powder waxy solid 127 yellow waxy solid liquid yellow liquid molecular wt solubility at 20ºC: forms liquid crystals i water, ethaol, ad glyceri; isoluble i propylee glycol; forms a solid wax with wheat germ, avocado, ad paraffi oils, ad squalee; at 65ºC: dispersible i water, clearly soluble i ethaol, i wheat germ, avocado, ad paraffi oils, ad squalee; turbid solubility i glyceri; isoluble i propylee glycol slightly soluble to soluble i water meltig poit ( C) desity (g/ml) specific gravity (g/ml) p refractive idex (20ºC) sapoificatio value acid value (mg K/g) 2.0 hydroxyl value (mg K/g) peroxide value (meq of active oxyge/kg) 1.0 iodie value (gi 2/100g) polarity LB ; ~11 ~5

76 Distributed for Commet ly -- Do Not Cite or Quote yellow liquid 138 waxy solid 25 Table 6. Physical ad Chemical Properties Polyglyceryl-3 Laurate 135 Polyglyceryl-4 Laurate Polyglyceryl-10 Laurate Polyglyceryl-10 Myristate 136 Polyglyceryl-3 leate Polyglyceryl-4 leate Polyglyceryl-10 leate physical characteristics viscous liquid viscous liquid 137 light yellow viscous amber liquid with a liquid 6 ester-like odor 139 molecular weight 422 (average) solubility dispersible i water 139 meltig poit ( C) desity (g/ml) 0.99 g/cm specific gravity (g/ml) p refractive idex (20ºC) sapoificatio value ; acid value (mg K/g) 6 max 5 max hydroxyl value (mg K/g) peroxide value (meq of active oxyge/kg) iodie value (gi 2/100g) polarity o-ioic 137 lipophilic 138 LB ~11 ~ Polyglyceryl-10 Palmate 142 Polyglyceryl-6 Petacaprylate 143 Polyglyceryl-3 Petacaprylate/ Caprate 144 Polyglyceryl-3 Petaoleate 145 Polyglyceryl-10 Petaoleate 146,147 physical characteristics liquid liquid liquid amber viscous liquid pale yellow to red-yellow viscous liquid molecular wt solubility slightly soluble i water slightly soluble to soluble i water Polyglyceryl-4 Petastearate 148 white to pale yellow pellet Polyglyceryl-6 Petastearate 149,150 pale yellow waxy solid easy to soluble i oil ad orgaic solvet, ad disperse ito hot water meltig poit ( C) desity (g/ml) specific gravity (g/ml) p refractive idex (20ºC) sapoificatio value acid value (mg K/g) 5.0 max 2.0 hydroxyl value (mg K/g) peroxide value (meq of active oxyge/kg) iodie value (gi 2/100g) 3.0 polarity o-ioic 145 LB ~7.0

77 Distributed for Commet ly -- Do Not Cite or Quote Table 6. Physical ad Chemical Properties Polyglyceryl-10 Petastearate 151,152 physical characteristics white to pale yellow solid molecular wt solubility Polyglyceryl-3 ice Braate 153 light ivory (waxy solid (flakes) dispersible i water; miscible i oils Polyglyceryl-3 icioleate 154 Polyglyceyl-2 Sesquicaprylate Polyglyceryl-2 Sesquioleate 155 Polyglyceryl-3 Soyate/Shea Butterate 156 Polyglyceryl-3 Stearate 127 yellow, trasparet highly viscous liquid liquid graules liquid 157 isoluble i water, soluble i castor oil, ethaol, mieral oil 157 meltig poit ( C) desity (g/ml) >1 g/ml (25ºC) specific gravity (g/ml) p refractive idex (20ºC) sapoificatio value acid value (mg K/g) hydroxyl value (mg K/g) peroxide value (meq of active oxyge/kg) iodie value (gi 2/100g) polarity o-ioic hydrophobic; o-ioic 157 LB ~4 slightly soluble to soluble i water (25ºC) Polyglyceryl-4 Stearate Polyglyceryl-10 Stearate 126,158 Polyglyceryl-2 Tetraisostearate 157 Polyglyceryl-10 Tetraoleate 159 Polyglyceryl-2 Tetrastearate 160 Polyglyceryl-10 Tricocoate 161 Polyglyceryl-10 Tridecaoate 162 physical characteristics pale yellow to light yellow liquid or solid yellow liquid viscous amber to brow liquid pale yellow viscous liquid liquid molecular wt solubility soluble i low ad isoluble i water isoluble i water slightly soluble i water high polar esters ad i vegetable oil, castor oil, ad mieral oil; isoluble i water ad ethaol meltig poit ( C) desity (g/ml) specific gravity (g/ml) p refractive idex (20ºC) sapoificatio value acid value (mg K/g) hydroxyl value (mg K/g) peroxide value (meq of active oxyge/kg) iodie value (gi 2/100g) polarity hydrophilic LB 12.0

78 Distributed for Commet ly -- Do Not Cite or Quote Table 6. Physical ad Chemical Properties Polyglyceryl-10 Triisostearate 163,164 Polyglyceryl-10 Trioleate 165 physical characteristics pale yellow liquid light yellow to redyellow viscous liquid Polyglyceryl-10 Tristearate 166 white to pale yellow waxy substace ice Brai il Polyglyceryl-3 Esters oily limpid liquid 167 clear, oily, amber-colored liquid 168 Safflower Seed il Polyglyceryl-6 Esters 102 amber (physical state ot specified) Schiziophyto autaeii Kerel il Polyglyceryl-6 Esters 103 brow liquid Sclerocarya Birrea Seed il Polyglyceryl-6 Esters 104 amber liquid molecular wt solubility isoluble i water dispersible i water; miscible i oils 167 meltig poit ( C) desity (g/ml) >1 <1 <1 <1 specific gravity (g/ml) p refractive idex (20ºC) approx approx approx sapoificatio value acid value (mg K/g) < 5 < 5 <5 hydroxyl value (mg K/g) peroxide value (meq of active oxyge/kg) <10 <10 <10 iodie value (gi 2/100g) polarity o-ioic o-ioic, amphiphilic o-ioic, amphiphilic LB Sesame il Polyglyceryl-6 Esters 105 Shea Butter Polyglyceryl-6 Esters 106 Soybea il Polyglyceryl-6 Esters 107 Suflower Seed il Polyglyceryl-10 Esters 109 Sweet Almod il Polyglyceryl-6 Esters 110 Trichilia Emetica Seed il Polyglyceryl-6 Esters 111 Triisostearoyl Polyglyceryl-3 Dimer Dilioleate 50,169,170 physical characteristics amber liquid beige solid dark orage liquid amber viscous liquid amber liquid dark brow soft paste hazy, viscous liquid molecular wt >1000 solubility water dispersible water dispersible water dispersible water dispersible water dispersible water dispersible meltig poit ( C) desity (g/ml) <1 <1 <1 >1 <1 <1 specific gravity (g/ml) p refractive idex (20ºC) approx approx approx approx approx approx sapoificatio value acid value (mg K/g) <5 <5 < 5 <5 <5 10 hydroxyl value (mg K/g) peroxide value (meq of <10 <10 <10 <10 <10 active oxyge/kg) iodie value (gi 2/100g) polarity o-ioic, amphiphilic o-ioic, amphiphilic o-ioic, amphiphilic o-ioic, amphiphilic o-ioic, amphiphilic o-ioic, amphiphilic LB

79 Distributed for Commet ly -- Do Not Cite or Quote Table 6. Physical ad Chemical Properties Ximeia Americaa Seed il Polyglyceryl-6 Esters 171 physical characteristics oil molecular wt solubility hydrodispersible - water soluble meltig poit ( C) desity (g/ml) specific gravity (g/ml) p refractive idex (20ºC) sapoificatio value acid value (mg K/g) hydroxyl value (mg K/g) peroxide value (meq of active oxyge/kg) iodie value (gi 2/100g) polarity LB

80 Distributed for Commet ly -- Do Not Cite or Quote Table 7. Specificatios, Impurities, ad/or Costituets Igrediet Specificatios/Impurities/Costituets eferece Diisostearoyl Polyglyceryl-3 Dimer Dilioleate PEG-free 114 Polyglyceryl-4 Caprate PEG-free 121 Polyglyceryl-6 Distearate 100% vegetable-derived ; PEG-free 134,172 Polyglyceryl-10 Distearate arseic = 0.002; heavy meals = Polyglyceryl-4 Laurate PEG-free 137 Polyglyceryl-4 leate 100 ppm D,L-tocopherol; <1% volatiles 139 Polyglyceryl-10 Myristate 2 ppm arseic; 20 ppm heavy metals 136 Abbreviatios: BT - butylated hydroxytoluee; EG polyethylee glycol

81 Distributed for Commet ly -- Do Not Cite or Quote Table 8. Frequecy ad cocetratio of use accordig to duratio ad type of exposure # of Uses 9 Max Coc of Use (%) # of Uses 9 Max Coc of Use (%) # of Uses 9 Max Coc of Use (%) Acacia Decurres/Jojoba/Suflower Seed Wax Polyglyceryl-3 Ester Babassu il Polyglyceryl-4 Esters Babassu il Polyglyceryl-6 Esters Totals* N Duratio of Use Leave- 9 2 N N N N ise-ff 1 N N Diluted for (Bath) Use N N N N N N Exposure Type Eye Area 1 N N N N N Icidetal Igestio 1 N N N N N Icidetal Ihalatio-Spray 2 a ; 1 b N N N N N Icidetal Ihalatio-Powder 1 b N N N N N Dermal Cotact N Deodorat (uderarm) N N N N N N air - No-Colorig N N 17 N N N air-colorig N N N N N N Nail N N N N N N Mucous Membrae 2 N N N N N Baby Products N N N N N N Cadelilla/Jojoba/ice Bra Polyglyceryl- 3 Esters Cocout il Polyglyceryl-6 Esters Diisostearoyl Polyglyceryl-3 Dimer Dilioleate Totals* N Duratio of Use Leave N N ise ff N N 2 N N N Diluted for (Bath) Use N N N N N N Exposure Type Eye Area 6 N N N 1 N Icidetal Igestio 1 N N N N N Icidetal Ihalatio-Spray 4 a ; 1 b N N N 2 a N Icidetal Ihalatio-Powder 1 b N N N N N Dermal Cotact N Deodorat (uderarm) N aerosol: 0.5 N N N N air - No-Colorig N N N N N N air-colorig N N N N N N Nail N N N N N N Mucous Membrae 1 N 1 N N N Baby Products N N N N Glyceryl/Polyglyceryl-6 Isostearate/Beheate Esters Macadamia Seed il Polyglyceryl-6 Esters Beheate Palm il Polyglyceryl-4 Esters N N Duratio of Use Leave N ise-ff N N N N N N Diluted for (Bath) Use N N N N N N Exposure Type Eye Area 2 N N N Icidetal Igestio 2 N N 25 N N Icidetal Ihalatio-Spray N N 1 a N 1 b N Icidetal Ihalatio-Powder N N N N 1 b N Dermal Cotact N Deodorat (uderarm) N N N N N N air - No-Colorig N N N N N N air-colorig N N N N N N Nail N N N N N N Mucous Membrae 2 N N 25 N N Baby Products N N N N N N

82 Distributed for Commet ly -- Do Not Cite or Quote Table 8. Frequecy ad cocetratio of use accordig to duratio ad type of exposure # of Uses 9 Max Coc of Use (%) # of Uses 9 Max Coc of Use (%) # of Uses 9 Max Coc of Use (%) Polyglyceryl-2 Caprate Polyglyceryl-2 Diisostearate Polyglyceryl-2 Isopalmitate Totals 5 N N Duratio of Use Leave- 5 N N ise ff N N N N Diluted for (Bath) Use N N N N N N Exposure Type Eye Area N N N N Icidetal Igestio N N N Icidetal Ihalatio-Spray 4 b N 8 a ; 15 b ; a N N Icidetal Ihalatio-Powder 4 b N 15 b 0.1; c N N Dermal Cotact 5 N N N Deodorat (uderarm) N N N 0.1 (ot spray) N N air - No-Colorig N N N N N air-colorig N N N N N N Nail N N N N N N Mucous Membrae N N N Baby Products N N N N N N Polyglyceryl-2 Isostearate Polyglyceryl-2 Laurate Polyglyceryl-2 leate Totals* Duratio of Use Leave ise-ff N 2.4 Diluted for (Bath) Use N N N N N N Exposure Type Eye Area N N 1 N N Icidetal Igestio N N N N N Icidetal Ihalatio-Spray N N 3 a ; 1 b N 3 a N Icidetal Ihalatio-Powder c 1 b N N 0.09 c Dermal Cotact N Deodorat (uderarm) N N N N N N air - No-Colorig N N N N air-colorig N N N N N N Nail N N N N N N Mucous Membrae N N N N Baby Products N N N N N N Polyglyceryl-2 Sesquiisostearate Polyglyceryl-2 Sesquistearate Polyglyceryl-2 Stearate Totals* N 0.9 N Duratio of Use Leave N N N ise-ff N 0.9 N 0.2 Diluted for (Bath) Use N N N N N N Exposure Type Eye Area N 2.1 N N N Icidetal Igestio N 7.6 N N N 0.2 Icidetal Ihalatio-Spray 2 a ; 2 b N N N N N Icidetal Ihalatio-Powder 2 b 4.4 c N N N 2.2 c Dermal Cotact N 0.9 N Deodorat (uderarm) N N N N N N air - No-Colorig N N N N N N air-colorig N N N N N N Nail N N N N N N Mucous Membrae N N N 0.2 Baby Products N N N N N N

83 Distributed for Commet ly -- Do Not Cite or Quote Table 8. Frequecy ad cocetratio of use accordig to duratio ad type of exposure # of Uses 9 Max Coc of Use (%) # of Uses 9 Max Coc of Use (%) # of Uses 9 Max Coc of Use (%) Polyglyceryl-2 Tetraisostearate Polyglyceryl-2 Triisostearate Polyglyceryl-3 Beeswax Totals Duratio of Use Leave ise ff N N Diluted for (Bath) Use N N N N N N Exposure Type Eye Area N N Icidetal Igestio Icidetal Ihalatio-Spray N N 8 a ; 2 b N 1; 12 a ; 7 c N Icidetal Ihalatio-Powder N ; 2 b ; 1-5 c 7 c 3.4; 4 c Dermal Cotact Deodorat (uderarm) N N N N N N air - No-Colorig N N N N N N air-colorig N N N 3 N N Nail N N N N N N Mucous Membrae Baby Products N N N N N N Polyglyceryl-3 Caprate Polyglyceryl-3 Caprylate Polyglyceryl-3 Dicitrate/Stearate Totals* 12 N Duratio of Use Leave- 11 N ise-ff 1 N N N Diluted for (Bath) Use N N N N N N Exposure Type Eye Area N N N N N N Icidetal Igestio N N N N N N Icidetal Ihalatio-Spray N N 1 b a N Icidetal Ihalatio-Powder N N N 0.05 c N 2-4 c Dermal Cotact 12 N Deodorat (uderarm) 11 a N 6 a ot spray: 0.5-1; N N aerosol: 0.6 air - No-Colorig N N N N air-colorig N N N N N N Nail N N N N N N Mucous Membrae 1 N N N Baby Products N N N N N N Polyglyceryl-3 Diisostearate Polyglyceryl-3 Distearate Polyglyceryl-3 Isostearate Totals* N Duratio of Use Leave N ise-ff N 2 N Diluted for (Bath) Use N N N N Exposure Type Eye Area N N Icidetal Igestio N N N N Icidetal Ihalatio-Spray 34 a ; 24 b a 3 3 a ; 4 b N Icidetal Ihalatio-Powder 24 b 0.25; c N 0.29 c 4 b N Dermal Cotact N Deodorat (uderarm) N (ot spray) N N N N air - No-Colorig N N N air-colorig N N N N N N Nail N N N N N N Mucous Membrae N N N N Baby Products N 2 N N N N

84 Distributed for Commet ly -- Do Not Cite or Quote Table 8. Frequecy ad cocetratio of use accordig to duratio ad type of exposure # of Uses 9 Max Coc of Use (%) # of Uses 9 Max Coc of Use (%) # of Uses 9 Max Coc of Use (%) Polyglyceryl-3 Laurate Polyglyceryl-3 leate Polyglyceryl-3 Petaricioleate Totals N 0.15 Duratio of Use Leave N 0.15 ise ff N N N Diluted for (Bath) Use N N N N N N Exposure Type Eye Area N N 0.15 Icidetal Igestio N N N N N N Icidetal Ihalatio-Spray 1 a ; 1 b N 6 a ; 2 b N N N Icidetal Ihalatio-Powder 1 b N 2 b N N N Dermal Cotact N 0.15 Deodorat (uderarm) N N N N N N air - No-Colorig N 1.2 N N air-colorig N N N N N N Nail N N N N N N Mucous Membrae 106 N N N N N Baby Products N N N N N N Polyglyceryl-3 icioleate Polyglyceryl-3 Stearate Polyglyceryl-4 Caprate Totals* Duratio of Use Leave ise-ff N N Diluted for (Bath) Use N N N N 1 N Exposure Type Eye Area 5 N N N 2 N Icidetal Igestio N N N N Icidetal Ihalatio-Spray 51 a ; 2 b N 2 a ; 8 b N 1 a ; 2 b 0.5 a Icidetal Ihalatio-Powder 2 b b N 2 b 0.72 c Dermal Cotact Deodorat (uderarm) N N N N 1 a 1.5 (ot spray) air - No-Colorig N N N N air-colorig N N N N N N Nail N N N N N N Mucous Membrae N N Baby Products N N N N N N Polyglyceryl-4 Isostearate Polyglyceryl-4 Laurate Polyglyceryl-4 leate Totals* Duratio of Use Leave N ise-ff N N Diluted for (Bath) Use N N N N N N Exposure Type Eye Area N 2 N Icidetal Igestio N N N N Icidetal Ihalatio-Spray 18 a ; 8 b 0.26; a 4 a N 3 a 1.8 Icidetal Ihalatio-Powder 3; 8 b ; 1 c 0.17; c N N N N Dermal Cotact Deodorat (uderarm) N N N N N N air - No-Colorig N N N N air-colorig N N N N N N Nail N N N N N N Mucous Membrae N N N N Baby Products 1 1 N N N N

85 Distributed for Commet ly -- Do Not Cite or Quote Table 8. Frequecy ad cocetratio of use accordig to duratio ad type of exposure # of Uses 9 Max Coc of Use (%) # of Uses 9 Max Coc of Use (%) # of Uses 9 Max Coc of Use (%) Polyglyceryl-5 Dioleate Polyglyceryl-5 Isostearate Polyglyceryl-5 Laurate Totals 1 N 2 N Duratio of Use Leave- N N 2 N N 0.6 ise ff 1 N N N Diluted for (Bath) Use N N N N 1 N Exposure Type Eye Area N N 1 N N N Icidetal Igestio N N N N N N Icidetal Ihalatio-Spray N N 1 b N N N Icidetal Ihalatio-Powder N N 1 b N N 0.6 c Dermal Cotact 1 N 2 N Deodorat (uderarm) N N N N N N air - No-Colorig N N N N N N air-colorig N N N N N N Nail N N N N N N Mucous Membrae 1 N N N 2 N Baby Products N N N N N N Polyglyceryl-5 leate Polyglyceryl-5 Stearate Polyglyceryl-5 Triisostearate Totals* N 1 N 1-5 Duratio of Use Leave N 1 N 1-5 ise-ff 2 N N N N N Diluted for (Bath) Use N N N N N N Exposure Type Eye Area N N N N N N Icidetal Igestio N N N N N 5 Icidetal Ihalatio-Spray 6 a 0.35 c N N N N Icidetal Ihalatio-Powder N N N 1 c N N Dermal Cotact N 1 N 1 Deodorat (uderarm) N N N N N N air - No-Colorig N N N N N N air-colorig N N N N N N Nail N N N N N N Mucous Membrae 1 N N N N 5 Baby Products N N N N N N Polyglyceryl-5 Trioleate Polyglyceryl-6 Caprylate/Caprate Polyglyceryl-6 Dioleate Totals* N Duratio of Use Leave- 6 N N N ise-ff N 2.8 N Diluted for (Bath) Use N N N N N N Exposure Type Eye Area N N N N N N Icidetal Igestio N N N N 2 N Icidetal Ihalatio-Spray 1 a ; 5 b N N N 2 a ; 7 b N Icidetal Ihalatio-Powder 5 b N N N 7 b 2.4 c Dermal Cotact 6 N N N Deodorat (uderarm) N N N N N N air - No-Colorig N 2.8 N air-colorig N N N N N N Nail N N N N N N Mucous Membrae N N N N 2 N Baby Products N N N N N N

86 Distributed for Commet ly -- Do Not Cite or Quote Table 8. Frequecy ad cocetratio of use accordig to duratio ad type of exposure # of Uses 9 Max Coc of Use (%) # of Uses 9 Max Coc of Use (%) # of Uses 9 Max Coc of Use (%) Polyglyceryl-6 Distearate Polyglyceryl-6 Isostearate Polyglyceryl-6 ctastearate Totals N 1 N Duratio of Use Leave N 1 N ise ff 1 N N N N N Diluted for (Bath) Use N N N N N N Exposure Type Eye Area 4 4 N N N N Icidetal Igestio N N N Icidetal Ihalatio-Spray 7 a ; 8 b N 4 a ; 8 b N 1 a N Icidetal Ihalatio-Powder 8 b ; 1 c N 8 b N N N Dermal Cotact N 1 N Deodorat (uderarm) N N N N N N air - No-Colorig N N N N N N air-colorig N N N N N N Nail N 5 N N N N Mucous Membrae N N N Baby Products N N N N N N Polyglyceryl-6 leate Polyglyceryl-6 Petastearate Polyglyceryl-6 icioleate Totals* 1 N N 5 1 N Duratio of Use Leave- 1 N N 5 1 N ise-ff N N N N N N Diluted for (Bath) Use N N N N N N Exposure Type Eye Area N N N 5 N N Icidetal Igestio N N N N 1 N Icidetal Ihalatio-Spray 1 b N N N N N Icidetal Ihalatio-Powder 1 b N N N N N Dermal Cotact 1 N N 5 N N Deodorat (uderarm) N N N N N N air - No-Colorig N N N N N N air-colorig N N N N N N Nail N N N N N N Mucous Membrae N N N N 1 N Baby Products N N N N N N Polyglyceryl-6 Tricaprylate Polyglyceryl-8 Decabeheate/Caprate Polyglyceryl-8 Decaerucate/Decaisostearate/Decaricioleate Totals* N 3.6 N 9 1 N Duratio of Use Leave- N 3.6 N 9 1 N ise-ff N N N N N N Diluted for (Bath) Use N N N N N N Exposure Type Eye Area N N N N N N Icidetal Igestio N N N 9 N N Icidetal Ihalatio-Spray N N N N 1 b N Icidetal Ihalatio-Powder N N N N 1 b N Dermal Cotact N 3.6 N N 1 N Deodorat (uderarm) N N N N N N air - No-Colorig N N N N N N air-colorig N N N N N N Nail N N N N N N Mucous Membrae N N N 9 N N Baby Products N N N N N N

87 Distributed for Commet ly -- Do Not Cite or Quote Table 8. Frequecy ad cocetratio of use accordig to duratio ad type of exposure # of Uses 9 Max Coc of Use (%) # of Uses 9 Max Coc of Use (%) # of Uses 9 Max Coc of Use (%) Polyglyceryl-10 Beheate/Eicosadioate Polglyceryl-10 Decaisostearate Polyglyceryl-10 Decaoleate Totals N Duratio of Use Leave- 1 2 N ise ff 1 5 N N N 0.01 Diluted for (Bath) Use N N N N N N Exposure Type Eye Area N N N 2.7 N N Icidetal Igestio N 2 N N 3 5 Icidetal Ihalatio-Spray N N N N 4 a N Icidetal Ihalatio-Powder N N N N N N Dermal Cotact 2 5 N Deodorat (uderarm) N N N N N N air - No-Colorig N N N N N N air-colorig N N N N N N Nail N N N N N N Mucous Membrae N 2 N N Baby Products N N N N N N Polyglyceryl-10 Diisostearate Polyglyceryl-10 Dioleate Polyglyceryl-10 Dipalmitate Totals* N Duratio of Use Leave N N 3 10 ise-ff N N 12 2 Diluted for (Bath) Use N N N N 2 2 Exposure Type Eye Area N N N N N N Icidetal Igestio N N N N 1 N Icidetal Ihalatio-Spray 3 a ; 4 b 2 a N N 1 b N Icidetal Ihalatio-Powder 4 b 0.8 c N N 1 b 10 c Dermal Cotact N Deodorat (uderarm) N N N N N N air - No-Colorig N 2 N N N N air-colorig N N N N N N Nail N N N N N N Mucous Membrae N N N N 12 2 Baby Products N N N N N N Polyglyceryl-10 Distearate Polyglyceryl-10 eptahydroxystearate Polyglyceryl-10 ydroxystearate/ Stearate/Eicosadioate Totals* 10 N N Duratio of Use Leave- 9 N N ise-ff 1 N N N Diluted for (Bath) Use N N N N N N Exposure Type Eye Area N N N N N N Icidetal Igestio N N N 2 N Icidetal Ihalatio-Spray 9 a N N N N N Icidetal Ihalatio-Powder N N N N N N Dermal Cotact 10 N N Deodorat (uderarm) N N N N N N air - No-Colorig N N N N N N air-colorig N N N N N N Nail N N N N N N Mucous Membrae 1 N N 2 N Baby Products N N N N N N

88 Distributed for Commet ly -- Do Not Cite or Quote Table 8. Frequecy ad cocetratio of use accordig to duratio ad type of exposure # of Uses 9 Max Coc of Use (%) # of Uses 9 Max Coc of Use (%) # of Uses 9 Max Coc of Use (%) Polyglyceryl-10 Isostearate Polyglyceryl-10 Laurate Polyglyceryl-10 Myristate Totals Duratio of Use Leave- N ise ff N N Diluted for (Bath) Use N N N N N Exposure Type Eye Area N N 5 N 1 N Icidetal Igestio N N N N N N Icidetal Ihalatio-Spray 3 a 0.6 (pump spray) 11 a ; 9 b 0.5; 6.5 a 6 a ; 3 b N Icidetal Ihalatio-Powder N N 9 b N 3 b 0.8 c Dermal Cotact Deodorat (uderarm) N N N N N ot spray: aerosol: 0.1 air - No-Colorig N N N air-colorig N N N N N N Nail N N N N N N Mucous Membrae N N N 2 N N Baby Products N N N Polyglyceryl-10 Noaisostearate Polyglyceryl-10 leate Polyglyceryl-10 Petahydroxystearate Totals* N Duratio of Use Leave- 58 N N ise-ff N N Diluted for (Bath) Use N N N 2 N N Exposure Type Eye Area 23 N N N Icidetal Igestio 26 N N N N N Icidetal Ihalatio-Spray N N 10 a ; 7 b 1 1 a N Icidetal Ihalatio-Powder N N 7 b c N N Dermal Cotact N N Deodorat (uderarm) N N N N 2 N air - No-Colorig N N N N air-colorig N N N N N N Nail N N N N N N Mucous Membrae 26 N N 2 N N Baby Products N N 1 N N N Polyglyceryl-10 Petaisostearate Polyglyceryl-10 Petaoleate Poolyglyceryl-10 Petastearate Totals* N Duratio of Use Leave- N ise-ff N N N N Diluted for (Bath) Use N N N N N N Exposure Type Eye Area N N 1 N 1 N Icidetal Igestio N N Icidetal Ihalatio-Spray N N 1; 1 a 1 a 6 a ; 3 b N Icidetal Ihalatio-Powder N 2 c N N 3 b c Dermal Cotact N 2 2 N Deodorat (uderarm) N N N N N N air - No-Colorig N N N air-colorig N N N N N N Nail N N N N N N Mucous Membrae N N Baby Products N N N N N N

89 Distributed for Commet ly -- Do Not Cite or Quote Table 8. Frequecy ad cocetratio of use accordig to duratio ad type of exposure # of Uses 9 Max Coc of Use (%) # of Uses 9 Max Coc of Use (%) # of Uses 9 Max Coc of Use (%) Polyglyceryl-10 Stearate Polyglyceryl-10 Tristearate Triisostearoyl Polyglyceryl-3 Dimer Dilioleate Totals* N Duratio of Use Leave N ise-ff 7 1 N N N N Diluted for (Bath) Use N N N N N N Exposure Type Eye Area N Icidetal Igestio N N N N Icidetal Ihalatio-Spray 28 a ; 30 b 0.25 a N N N N Icidetal Ihalatio-Powder 30 b c N N N N Dermal Cotact N Deodorat (uderarm) N N N N N N air - No-Colorig N N N N air-colorig N N N N N N Nail N N N N N N Mucous Membrae N N N N Baby Products N N N N N N *Because each igrediet may be used i cosmetics with multiple exposure types, the sum of all exposure types may ot equal the sum of total uses. a Icludes products that ca be sprays, but it is ot kow whether the reported uses are sprays b Not specified whether this product is a spray or a powder or either, but it is possible it may be a spray or a powder, so this iformatio is captured for both categories of icidetal ihalatio c Icludes products that ca be powders, but it is ot kow whether the reported uses are powders N o reported use NS survey results have ot yet bee received Table 9. Supplier ecommeded Use Levels Igrediet Supplier-ecommeded Cocetratio eferece Acacia Decurres/Jojoba/ Suflower Seed Wax Polyglyceryl 3 Esters 1-5% 173 Diisostearoyl Polyglyceryl-3 Dimer Dilioleate 3.0% 114 Polyglyceyrl-4 Caprate 2-10% 121 Polyglyceryl-3 Caprylate 0.2-2% 118 Polyglyceryl-10 Caprylate/Caprate 1-7% 119 Polyglyceryl-4 Cocoate 1-5% 174 Polyglyceryl-6 Distearate 1-3% Polyglyceryl-10 Eicosaedioate/Tetradecaedioate 1-10% 175 Polyglyceyrl-4 Isostearate 2.5-4% 132 Polyglyceryl-4 Laurate (i o/w lotio wipes) % i cocetrates % i impregatig liquids Polyglyceryl-10 Laurate (~60% pure, with ~40% polyglyceri-10 ad 3% 20 ~2% sodium laurate) Polyglyceryl-3 leate 2.5-4% 138 Polyglyceryl-10 leate 1-7% 141 Polyglyceryl-3 icioleate 3.5-4% (w/o emulsios); 5-25% (ahydrous products) 154 Polyglyceryl-2 Sesquioleate 2-3% 155

90 Distributed for Commet ly -- Do Not Cite or Quote Table 10. Igrediets Not eported to be Used 9-14 Adasoia Digitata Seed il Polyglyceryl-6 Esters Polyglyceryl-3 ice Braate Almod il/polyglyceryl-10 Esters Polyglyceryl-3 Soyate/Shea Butterate Apricot Kerel il Polyglyceryl-3 Esters Polyglyceryl-3 Stearate SE Apricot Kerel il Polyglyceryl-4 Esters Polyglyceryl-3 Triisostearate Apricot Kerel il Polyglyceryl-5 Esters Polyglyceryl-3 Triolivate Apricot Kerel il Polyglyceryl-6 Esters Polyglyceryl-4 Almodate/Shea Butterate Apricot Kerel il Polyglyceryl-10 Esters Polyglyceryl-4 Caprylate Arga il Polyglyceryl-6 Esters Polyglyceryl-4 Caprylate/Caprate Astrocaryum Vulgare il Polyglyceryl-6 Esters Polyglyceryl-4 Cocoate Avocado il Polyglyceryl-6 Esters Polyglyceryl-4 Dilaurate Bertholletia Excelsa Seed il Polyglyceryl-6 Esters Polyglyceryl-4 Distearate Borage Seed il Polyglyceryl-4 Esters Polyglyceryl-4 azelutseedate Borage Seed il Polyglyceryl-6 Esters Polyglyceryl-4 Isostearate/Laurate Caprylic/Capric Glycerides Polyglyceryl-10 Esters Polyglyceryl-4 Laurate/Sebacate Carapa Guaiaesis il Polyglyceryl-6 Esters Polyglyceryl-4 Laurate/Succiate Castor il Polyglyceryl-6 Esters Polyglyceryl-4 Petaoleate Cocoa Butter Polyglyceryl-6 Esters Polyglyceryl-4 Petapalmitate/Stearate Coffee Seed il Polyglyceryl-6 Esters Polyglyceryl-4 Petastearate azelut Seed il Polyglyceryl-6 Esters Polyglyceryl-4 Puicate Liseed il Polyglyceryl-4 Esters Polyglyceryl-4 Stearate Macadamia Seed il Polyglyceryl-6 Esters Polyglyceryl-4 Sweet Almodate Mauritia Flexuosa Seed il Polyglyceryl-6 Esters Polyglyceryl-4 Tristearate live il Polyglyceryl-3 Esters Polyglyceryl-5 Caprate live il Polyglyceryl-4 Esters Polyglyceryl-5 Dicaprylate live il Polyglyceryl-6 Esters Polyglyceryl-5 Dilaurate Palm Kerel il Polyglyceryl-4 Esters Polyglyceryl-5 exastearate Palm il Polyglyceryl-3 Esters Polyglyceryl-5 Myristate Palm il Polyglyceryl-5 Esters Polyglyceryl-5 Petamyristate Palm il Polyglyceryl-6 Esters Polyglyceryl-5 icioleate Pariari Curatellifolia il Polyglyceryl-6 Esters Polyglyceryl-5 Tribeheate Pius Sibirica Seed il Polyglyceryl-6 Esters Polyglyceryl-5 Trimyristate Polyglyceryl-2 Caprylate Polyglyceryl-5 Tristearate Polyglyceryl-2 Dioleate Polyglyceryl-6 Adasoia Digitata Seedate Polyglyceryl-2 Distearate Polyglyceryl-6 Apricot Kerelate Polyglyceryl-2 Isopalmitate/Sebacate Polyglyceryl-6 Arga Kerelate Polyglyceryl-2 Myristate Polyglyceryl-6 Beheate Polyglyceryl-2 Palmitate Polyglyceryl-6 Caprate Polyglyceryl-2 Sesquicaprylate Polyglyceryl-6 Caprylate Polyglyceryl-2 Sesquioleate Polyglyceryl-6 Citrullus Laatus Seedate Polyglyceryl-2 Tetrabeheate/ Macadamiate/Sebacate Polyglyceryl-6 Dicaprate Polyglyceryl-2 Tetraoleate Polyglyceryl-6 Diisostearate Polyglyceryl-2 Tetrastearate Polyglyceryl-6 Dipalmitate Polyglyceryl-3 Beheate Polyglyceryl-6 eptacaprylate Polyglyceryl-3 Cocoate Polyglyceryl-6 exaoleate Polyglyceryl-3 Dicaprate Polyglyceryl-6 exastearate Polyglyceryl-3 Dicocoate Polyglyceryl-6 Laurate Polyglyceryl-3 Di-ydroxystearate Polyglyceryl-6 Myristate Polyglyceryl-3 Dioleate Polyglyceryl-6 ctacaprylate Polyglyceryl-3 Myristate Polyglyceryl-6 Palmitate Polyglyceryl-3 Palmitate Polyglyceryl-6 Palmitate/Succiate Polyglyceryl-3 Petacaprylate/Caprate Polyglyceryl-6 Petacaprylate Polyglyceryl-3 Petaolivate Polyglyceryl-6 Petaoleate Polyglyceryl-6 Petaricioleate Polyglyceryl-6 Schiziophyto autaeii Kerelate Polyglyceryl-6 Sclerocarya Birrea Seedate Polyglyceryl-6 Sesquicaprylate Polyglyceryl-6 Sesquiisostearate Polyglyceryl-6 Sesquistearate Polyglyceryl-6 Stearate Polyglyceryl-6 Tetrabeheate Polyglyceryl-6 Tetracaprylate Polyglyceryl-6 Tetraoleate Polyglyceryl-6 Trichilia Emetica Seedate Polyglyceryl-6 Tristearate Polyglyceryl-6 Udecyleate Polyglyceryl-6 Ximeia Americaa Seedate Polyglyceryl-8 C12-20 Acid Ester Polyglyceryl-8 leate Polyglyceryl-8 Stearate Polyglyceryl-10 Apricot Kerelate Polyglyceryl-10 Caprate Polyglyceryl-10 Caprylate Polyglyceryl-10 Caprylate/Caprate Polyglyceryl-10 Cocoate Polyglyceryl-10 Decaethylhexaoate Polyglyceryl-10 Decahydroxystearate Polyglyceryl-10 Decalioleate Polyglyceryl-10 Decamacadamiate Polyglyceryl-10 Decastearate Polyglyceryl-10 Dicocoate Polyglyceryl-10 Didecaoate Polyglyceryl-10 Dilaurate Polyglyceryl-10 Dimyristate Polyglyceryl-10 Dodecabeheate Polyglyceryl-10 Dodecacaprate Polyglyceryl-10 Dodecacaprylate Polyglyceryl-10 Dodeca-Caprylate/ Caprate Polyglyceryl-10 Eicosaedioate/Tetradecaedioate Polyglyceryl-10 epta(beheate/stearate) Polyglyceryl-10 eptaoleate Polyglyceryl-10 eptastearate Polyglyceryl-10 exaerucate Polyglyceryl-10 exaisostearate Polyglyceryl-10 exaoleate Polyglyceryl-10 Lioleate Polyglyceryl-10 Moo/Dioleate Polyglyceryl-10 Noaerucate Polyglyceryl-10 Palmate Polyglyceryl-10 Palmitate Polyglyceryl-10 Petacaprylate Polyglyceryl-10 Petalaurate Polyglyceryl-10 Petalioleate Polyglyceryl-10 Petaricioleate Polyglyceryl-10 Sesquistearate Polyglyceryl-10 Tetradecaedioate Polyglyceryl-10 Tetralaurate Polyglyceryl-10 Tetraoleate Polyglyceryl-10 Tricocoate Polyglyceryl-10 Tridecaoate Polyglyceryl-10 Trierucate Polyglyceryl-10 Triisostearate Polyglyceryl-10 Trilaurate Polyglyceryl-10 Trioleate Polyglyceryl-10 Udecyleate Polyglyceryl-15 Diisostearate Polyglyceryl-20 Docosabeheate/Isostearate Polyglyceryl-20 Docosabeheate/Laurate Polyglyceryl-20 Docosabeheate/leate Polyglyceryl-20 eptacaprylate Polyglyceryl-20 eptadecabeheate/laurate Polyglyceryl-20 exacaprylate Polyglyceryl-20 ctadecabeheate/laurate Polyglyceryl-20 ctaisooaoate Pumpki Seed il Polyglyceryl-4 Esters Pumpki Seed il Polyglyceryl-4 Esters Succiate ice Bra il Polyglyceryl-3 Esters osa ubigiosa Seed il Polyglyceryl-6 Esters Safflower Seed il Polyglyceryl-6 Esters Schiziophyto autaeii Kerel il Polyglyceryl-6 Esters Sclerocarya Birrea Seed il Polyglyceryl-6 Esters Sclerocarya Birrea Seed il Polyglyceryl-10 Esters Sesame il Polyglyceryl-6 Esters Shea Butter Polyglyceryl-3 Esters Shea Butter Polyglyceryl-4 Esters Shea Butter Polyglyceryl-6 Esters Soybea il Polyglyceryl-6 Esters Suflower Seed il Polyglyceryl-3 Esters Suflower Seed il Polyglyceryl-4 Esters Suflower Seed il Polyglyceryl-5 Esters Suflower Seed il Polyglyceryl-6 Esters Suflower Seed il Polyglyceryl-10 Esters Sweet Almod il Polyglyceryl-4 Esters Sweet Almod il Polyglyceryl-6 Esters Theobroma Gradiflorum Seed Butter Polyglyceryl-6 Esters Trichilia Emetica Seed il Polyglyceryl-6 Esters Watermelo Seed il Polyglyceryl-6 Esters Watermelo Seed il Polyglyceryl-10 Esters Ximeia Americaa Seed il Polyglyceryl-6 Esters

91 Distributed for Commet ly -- Do Not Cite or Quote Table 11. Dispositio of radioactivity i rats after a sigle oral dose Catabolism Study 31 % radioactivity recovered C 2 urie Feces GI cotets carcass Test Compoud - Igrediets [ 14 C]Polyglyceryl-10 leate [ 14 C]Polyglyceryl-10 Decaoleate polyglyceryl-3 [ 14 C]oleate polyglyceryl-10 [ 14 C]oleate polyglyceryl-10 [ 14 C]decaoleate For Compariso glycerol-1,3-14 C [ 14 C]polyglyceri [ 14 C]polyglyceri triglycerol [ 14 C]tetraoleate polyglyceri-10 [ 14 C]mooeicosaoate Test Compoud - Igrediets Catabolism- Absorptio Study 31 % radioactivity recovered C 2 urie feces GI cotets carcass lymph [ 14 C]Polyglyceryl-10 leate [ 14 C]Polyglyceryl-10 Decaoleate polyglyceryl-3 [ 14 C]oleate polyglyceryl-10 [ 14 C]oleate polyglyceryl-10 [ 14 C]decaoleate For Compariso glycerol-1,3-14 C [ 14 C]polyglyceri [ 14 C]polyglyceri triglycerol [ 14 C]tetraoleate polyglyceri-10 [ 14 C]mooeicosaoate 8.9

92 Distributed for Commet ly -- Do Not Cite or Quote Table 12. Acute Toxicity Studies Igrediet Aimals No./Group Vehicle Cocetratio/Dose/Protocol LD 50/esults eferece 1,2,3-propaetriol, homopolymer, diisooctadecaoate ( ot defied; most likely Polyglyceryl-3 Diisostearate) polyglyceryl ester (uspecified) polyglyceryl ester (uspecified) DEMAL Polyglyceryl Multi-Esters Wistar rats 5/sex udiluted ECD test guidelie g/kg (5.2 ml/kg bw) was applied with a semi-occlusive patch for 24 h >5 g/kg o local effects were observed AL rats ot provided ot specified 7, 14 ad 29 g/kg bw by gavage o sigs of ay toxic effect rabbits ot provided ot specified g/kg bw o sigs of ay toxic effect Polyglyceryl-3 Caprate rat ot provided ot specified ECD 401 (acute oral toxicity by gavage) LD 50 > 2 g/kg Polyglyceryl-3 Caprylate rat ot provided ot specified ECD 423 (acute oral toxicity by LD 50 > 2 g/kg gavage) Polyglyceryl-3 Isostearate rat ot provided ot specified FSA, 16 CF LD 50 > 5 g/kg Polyglyceryl-3 leate rat ot provided ot specified FSA, 16 CF LD 50 > 5 g/kg Polyglyceryl-4 Caprate rat ot provided ot specified ECD 401 (acute oral toxicity by LD 50 > 2 g/kg gavage) Polyglyceryl Multi-Esters Polyglyceryl-2 Diisostearate female 10 water ot provided >5 g/kg Wistar rats Polyglyceryl-2 Diisostearate rats 5/sex ot specified ot provided >5 g/kg Polyglyceryl-3 Diisostearate NMI mice 5 females ot specified 2 g/kg >2 g/kg 1,2,3-propaetriol, homopolymer, diisooctadecaoate ( ot defied; most likely Polyglyceryl-3 Diisostearate) Diisostearoyl Polyglyceryl-3 Dimer Dilioleate tetraisostearoyl polyglyceryl- 3 dimer dilioleate (as readacross for Diisostearoyl Polyglyceryl-3 Dimer Dilioleate ad Triisostearoyl Polyglyceryl-3 Dimer Dilioleate) Wistar rats 5/sex peaut oil ECD test guidelie % (w/v) by gavage rat ot provided ot specified ECD 423 (acute oral toxicity by gavage) >5 g/kg rats ot provided ot provided ot provided >5 g/kg LD 50 > 2 g/kg bs Abbreviatios: CF Code of Federal egulatios; FSA Federal azardous Substaces Act; ECD rgaisatio for Ecoomic Co-operatio ad Developmet , ,48

93 Distributed for Commet ly -- Do Not Cite or Quote Table 13. Geotoxicity studies Test Article Cocetratio/Vehicle Test System Procedure esults eferece Polyglyceryl-2 leate µg/plate i DMS S. typhimurium TA1535, TA1537, TA98 ad TA100; E. coli WP2uvrA Polyglyceryl-2 leate Polyglyceryl-2 leate µg/ml, 4-h exposure with ad without activatio 5-75 µg/ml, 24-h exposure without activatio i DMS ad µg/ml, 4-h exposure without ad with activatio, respectively; µg/ml, 22-h exposure without activatio i DMS mouse lymphoma L5178Y cells huma peripheral blood lymphocytes IN VIT Polyglyceryl Mooesters Ames test, with ad without metabolic activatio (ECD Guidelie 471) mammalia cell gee mutatio assay, with ad without metabolic activatio (ECD test guidelie 476) chromosomal aberratio assay, with ad without metabolic activatio (ECD Guidelie 473) ot mutageic cytotoxic at 5000 µg/plate i strai TA1537 without activatio ad TA1535 with activatio positive ad vehicle cotrols gave expected results ot geotoxic cytotoxic without activatio at 30 µg/ml ad with activatio at 50 µg/m positive ad vehicle cotrols gave expected results ot geotoxic positive ad vehicle cotrols gave expected results Polyglyceryl-3 Caprate ot provided ot provided Ames test; ECD 471 ot evidece of mutageic activity Polyglyceryl-3 Caprylate ot provided ot provided Ames test; ECD 471 ot evidece of mutageic activity Polyglyceryl-3 Laurate µg/plate (vehicle ot ot provided Ames test; details ot provided egative specified) Polyglyceryl-3 Isostearate ot provided ot provided Ames test; details ot provided ot evidece of mutageic activity Polyglyceryl-4 Caprate ot provided ot provided Ames test; ECD 471 ot evidece of mutageic activity Polyglyceryl-4 Isostearate ot provided ot provided Ames test; details ot provided egative Polyglyceryl-4 Laurate/Succiate µg/plate i distilled water S. typhimurium TA1535, Ames test, with ad without metabolic activatio ot mutageic TA1537, TA98, TA100; E. coli cytotoxicity was observed i S. WP2uvrA typhimurium with several cocetratios positive ad vehicle cotrols gave expected results Polyglceryl-6 Caprylate/Caprate Polyglyceryl-10 Laurate (~60% pure, with ~40% polyglyceri-10 ad ~2% sodium laurate) µg/plate i distilled water S. typhimurium TA1535, TA1537, TA98, TA100; E. coli WP2uvrA µg/ml without activatio µg/ml with activatio Ames test, with ad without metabolic activatio ot mutageic cytotoxicity was observed with several cocetratios positive ad vehicle cotrols gave expected results Chiese hamster V79 cells chromosomal aberratio assay; 20 h harvest time equivocal without ad positive with activatio without activatio, a slight icrease of aberrat cells was see with 50 ad 70, but ot 65, µg/ml with activatio, the aberratio rates with 1250 ad 1500 µg/ml were sigificatly icreased, ad a dose relatioship was observed

94 Distributed for Commet ly -- Do Not Cite or Quote Table 13. Geotoxicity studies Test Article Cocetratio/Vehicle Test System Procedure esults eferece Polyglyceryl-10 Laurate (~60% pure, with ~40% polyglyceri-10 ad ~2% sodium laurate) µg/ml, 4-h exposure without ad with activatio µg/ml, 20-h exposure without activatio Polyglyceryl-2 Diisostearate µg/plate i acetoe S. typhimurium TA1535, Polyglyceryl-2 Diisostearate Polyglyceryl-2 Diisostearate 1,2,3-propaetriol, homopolymer, diisooctadecaoate ( ot defied; most likely Polyglyceryl-3 Diisostearate) 1,2,3-propaetriol, homopolymer, diisooctadecaoate ( ot defied; most likely Polyglyceryl-3 Diisostearate) 1,2,3-propaetriol, homopolymer, diisooctadecaoate ( ot defied; most likely Polyglyceryl-3 Diisostearate) µg/ml, 4-h exposure without ad with activatio µg/ml, 20-h exposure without activatio cell culture medium (MEM) served as the vehicle µg/ml i cell culture medium (MEM) µg/plate i Twee 80/bidistilled water µg/ml, 4-h exposure without activatio µg/ml, 4-h exposure with activatio i DMS µg/ml without ad µg/ml with activatio, i DMS huma peripheral lymphocytes chromosomal aberratio assay; 20 h harvest time metaphase aalysis was performed with cultures exposed to µg/ml for 4 h ad µg/ml for 20 h without metabolic activatio, ad to µg/ml with metabolic activatio Polyglyceryl Multi-esters Ames test, with ad without metabolic activatio TA1537, TA98, TA100 (ECD test guidelie 471) Chiese hamster lug fibroblasts V79 cells Chiese hamster lug fibroblasts V79 cells S. typhimurium TA1535, TA1537, TA1538, TA98 ad TA100 C cells Chiese hamster lug fibroblasts V79 cells ot clastogeic; o sigificat icreases i chromosomal aberrat aberratios were observed i ay treatmet group at ay dose level ot mutageic mammalia cell gee mutatio assay, with ad o evidece of a cocetratio-related without metabolic activatio (ECD test guidelie 476); 20 h harvest time positive respose chromosomal aberratios were evaluated i cultures exposed to µg/ml for 4 h ad µg/ml for 20 h without metabolic activatio, ad to µg/ml with metabolic activatio chromosomal aberratio assay, with ad without ot clastogeic metabolic activatio (ECD test guidelie 473) Ames test, with ad without metabolic activatio (ECD Guidelie 471) mammalia cell gee mutatio assay, with ad without metabolic activatio (ECD test guidelie 476); 4-h exposure chromosomal aberratio assay, with ad without metabolic activatio (ECD test guidelie 473); 4 ad 18-h exposure ot mutageic positive ad vehicle cotrols gave expected results ot geotoxic positive ad egative cotrols gave expected results ot clastogeic Diisostearoyl Polyglyceryl-3 Dimer Dilioleate ot provided ot provided Ames test; ECD 471 egative Abbreviatios: C Chiese hamster ovary; DMS dimethyl sulfoxide; MEM miimum essetial medium; ECD rgaisatio for Ecoomic Co-operatio ad Developmet

95 Distributed for Commet ly -- Do Not Cite or Quote Table 14. Dermal irritatio ad sesitizatio Test Article Cocetratio/Dose test system/# per Group Apricot Kerel il Polyglyceryl-4 Esters 16 ± 0.5 µl recostituted huma epidermis Palm il Polyglyceryl-4 Esters 16 ± 0.5 µl recostituted huma epidermis Polyglyceryl-4 Laurate/Sebacate eat recostituted huma epidermis Polyglyceryl-4 Laurate/Succiate eat Polyglyceryl-6 Caprylate/Caprate eat recostituted huma epidermis recostituted huma epidermis Procedure esults eferece ALTENATIVE STUDIES Polyglyceryl Mooesters SkiEthic TM irritatio test; test material was applied for 42 mi; cell viability assessmet by MTT method after 42 h SkiEthic TM irritatio test; test material was applied for 42 mi; cell viability assessmet by MTT method after 42 h EpiSki TM model; 15 mi treatmet period with a 42 h post-exposure icubatio period; cell viability was measured by MTT reductio EpiSki TM model; 15 mi treatmet period with a 42 h post-exposure icubatio period; cell viability was measured by MTT reductio EpiSki TM model; 15 mi treatmet period with a 42 h post-exposure icubatio period; cell viability was measured by MTT reductio ANIMAL Polyglyceryl Mooesters Polyglyceryl-2 Isostearate udiluted; 0.5 ml 3 NZW rabbits ECD test guidelie h, 2 x 3 cm semi-occlusive patch applied to clipped ski classified as o-irritat classified as o-irritat Polyglyceryl-3 Caprate ot provided rabbit ECD 404 (acute dermal irritatio/corrosio) ot irritatig cosidered to be o-irritat relative mea viability was 105.4% cosidered to be o-irritat relative mea viability was 104.1% cosidered to be o-irritat relative mea viability was 105.7% Polyglyceryl-3 Caprate ot provided guiea pig ECD 406 (sesitizatio) o ski sesitizatio effect a polyglyceryl moo/diester of capric acid (C10) (provided as read-across for Polyglyceryl-3 Caprylate) ot provided rabbit ECD 404 (acute dermal irritatio/corrosio) ot irritatig Polyglyceryl-3 Caprylate ot provided ot stated ECD 429; LLNA ot sesitizig Polyglyceryl-3 Isostearate ot provided rabbit FSA, 16 CF moderately irritatig Polyglyceryl-3 Isostearate ot provided guiea pig ECD 406 (sesitizatio) o ski sesitizatio effect Polyglyceryl-3 leate ot provided rabbit FSA, 16 CF moderately irritatig Polyglyceryl-4 Caprate ot provided rabbit ECD 404 (acute dermal irritatio/corrosio) ot irritatig Polyglyceryl-4 Caprate ot provided guiea pig ECD 406 (sesitizatio) o ski sesitizatio effect Polyglyceryl-4 Isostearate ot provided guiea pig ECD 406 (sesitizatio) o sesitizig effect Polyglyceryl Multi-Esters Polyglyceryl-2 Diisostearate udiluted; 0.5 ml 3 NZW rabbits ECD test guidelie h, 2.5 cm 2 semi-occlusive patch Polyglyceryl-2 Diisostearate 1 ad 10% i salie, ad udiluted; 0.5 ml 2 Albio-imalaya- Kaiche rabbits/gp 24-h, 2.5 cm 2 occlusive patch o itact ad abraded ski PII of 0.8 (mildly irritatig); very slight erythema was observed i all 3 aimals ad resolved i 2-7 days o-irritatig; 1 aimal had well-defied erythema 24 h after patch removal slightly irritatig; with udiluted test substace, distict erythema ad slight to distict edema was observed i both aimals; with 10%, marked erythema was observed i 1 aimal for a short time; with 1%, slight erythema i 1 aimal

96 Distributed for Commet ly -- Do Not Cite or Quote Table 14. Dermal irritatio ad sesitizatio Test Article Cocetratio/Dose test system/# per Group Polyglyceryl-2 Diisostearate iductio: 100% challege: 20% i acetoe 20 female Pirbright- White guiea pigs/gp Procedure esults eferece Buehler test usig occlusive patches; 10 cotrol aimals were exposed to a ethaol-water (80:20) mixture Polyglyceryl-3 Diisostearate ot specified 3 NZW rabbits method was described as ECD Guidelie 404, but study details were ot provided; test sites were scored accordig to Draize Polyglyceryl-3 Diisostearate 1,2,3-propaetriol, homopolymer, diisooctadecaoate ( ot defied; most likely Polyglyceryl-3 Diisostearate) Polyglyceryl-3 Diisostearate 5-50% i paraffi perliquid DAB 8 3 Pirbright-White guiea pigs i a rage-fidig study for a sesitizatio test, the test material was applied to the shaved flak for 6 h udiluted; 0.5 ml 4 male rabbits ECD Guidelie 404; 4-h occlusive patch to a shaved 6.25 cm² area iductio: 50% i paraffi perliquid DAB 8 (iductio 1) or i petrolatum (iductios 2 ad 3) challege: 50% paraffi perliquid DAB 8 rechallege: 25% Polyglyceryl-3 Diisostearate iductio: 0.1% or 0.2% (itradermal) ad 40% (epicutaeous) challege: 10 ad 15% rechallege: 8 ad 4% i paraffium perliquidum DAB 8 20 (test) or 19 (cotrol) female Pirbright-White guiea pigs 20 (test) or 19 (cotrol) female Pirbright-White guiea pigs test sites were pre-treated with 10% SDS i petrolatum, 24 h prior to each iductio applicatio epicutaeous iductio: 6-h occlusive patches (0.2 ml) applied 1x/wk for 3 wks; half of the cotrols were pretreated with SDS 24 h prior to applicatio of patches cotaiig vehicle challege: 6-h occlusive patch (0.1 ml) applied o day 28 rechallege: 6-h occlusive patch (0.1 ml) applied o day 35 GPMT, with FCA; o positive cotrol itradermal iductio: 3 pairs of ijectios o day1 cosistig of (1) 0.1 ml of a 1:1 mixture (v/v) FCA/physiological salie i water); (2) 0.1 ml test 0.1% substace i paraffi perliquid DAB 8; (3) 0.1 ml of a 1:1 mixture (v/v) of 0.2% test substace i paraffi perliquid DAB 8 ad 50% FCA i physiological salie epicutaeous iductio: 48-h occlusive patch (1 ml) o day 8 challege: 24-h occlusive patches o day 22 (0.1 ml) rechallege: 24 h occlusive patches o day 29 (0.1 ml) o-sesitizig ot irritatig; slight erythema was see o ski of all 3 aimals tested startig 1 hour followig applicatio, ad this effect was fully reversible withi by 72 h ot irritatig after 24 h ot irritatig; very slight to slight erythema i 3/4 aimals at 24 ad 48 h; slight ad moderate erythema i 2/4 aimals at 72 h; the effects were reversible i all aimals withi 7 d o-sesitizig very slight ski reactios (erythema ad edema) were see at 24-h followig the challege ad rechallege patches i test ad cotrol aimals; these reactios were reversible i all aimals withi 48 h ad were attributed to irritatio results were icoclusive itradermal iductio: 0.1 ml FCA (50% (v/v)), the test substace (0.1% (v/v)) ad a 1:1 mixture of the test substace with FCA caused moderate to severe ski reactios; i the cotrol group, 0.1 ml of the vehicle resulted i moderate ski reactios epicutaeous iductio: after treatmet with 40% of the test substace, the ijectio sites of the itradermal iductio were bloody ad purulet ad at a later stage, this sites showed ecrotic ad scabby ski lesios challege with 15%: at 24 h, erythema (1) was observed i 9 test ad 2 cotrol aimals; edema (2) i 1 test aimal, ad edema (1) i 2 test ad 2 cotrol aimals; at 48 h, erythema (2) i 1 test aimal (that was 0 at 24 h), erythema (1) i 7 test aimals, same edema scores as at 24 h for test aimals, o edema i cotrols challege with 10%: at 24 h, erythema (3) i 1 ad erythema (1) i 5 test aimals, edema (3) i 1 ad edema (2) i 1 test aimal; at 48 h, erythema (3) ad edema (3) i 1 aimal ad erythema (1) ad edema (1) i 1 test aimal; o erythema or edema i cotrols at 24 or 48 h rechallege with 8%: at 24 h, erythema (1) i 6 test ad 4 cotrol aimals, o edema i test or cotrols; at 48-h, erythema (1) i 3 test ad 1 cotrol aimals, o edema i test or cotrols rechallege with 4%: o erythema or edema 33 44,

97 Distributed for Commet ly -- Do Not Cite or Quote Table 14. Dermal irritatio ad sesitizatio Test Article Cocetratio/Dose test system/# per Procedure esults eferece Group Polyglyceryl-4 Diisostearate/ Polyhydroxystearate/Sebacate (provided as read-across for Diisostearoyl Polyglyceryl-3 Dimer Dilioleate) ot provided guiea pig ECD 406 (sesitizatio) ot sesitizig 46 Polyglyceryl-2 Isostearate 7% i ESTL 1512 (i.e., isopropyl myristate); 0.4 ml UMAN Polyglyceryl Mooesters 30 subjects three 24-h occlusive patches, with 24 to 48-h betwee applicatios elicited slight irritatio; sigificatly less irritatig tha the positive cotrol (0.3% sodium lauryl sulfate) ad sigificatly more irritatig tha the egative cotrol (deioized water) (p=0.05) Polyglyceryl-3 Laurate 100%; 150 µl/patch 114 subjects IPT ot a irritat or a sesitizer Polyglyceryl-10 Myristate 10% 48 subjects 48-h occlusive patch test egative Polyglyceryl-10 Stearate 10% 48 subjects 48-h occlusive patch test o-irritatig 60% Polyglyceryl-10 Eicosaedioate/ udiluted 45 subjects closed patch test; details ot provided egative Tetradecaedioate/40% gly- ceri mixture Polyglyceryl Multi-Esters Polyglyceryl-2 Sesquiisostearate udiluted 50 subjects 24-h semi-occlusive patches ot irritatig 1,2,3-propaetriol, homopolymer, diisooctadecaoate ( ot defied; likely Polyglyceryl-3 Diisostearate) 20% active substace i cosmetic alcohol ; 70 µl 20 subjects 24-h occlusive patches ot irritatig slight erythema i 3 ad slight scalig i 2 subjects Diisostearoyl Polyglyceryl-3 ot provided o provided occlusive patch test; details ot provided o cocer 46 Dimer Dilioleate Triisostearoyl Polyglyceryl-3 100%; 150 µl/patch 103 subjects IPT ot a irritat or a sesitizer 50 Dimer Dilioleate Polyglyceryl-10 Petaisostearate 50% 44 Japaese subjects 24-h occlusive patch egative 61 Polyglyceryl-10 Decaoleate eat 44 Japaese subjects 24-h occlusive patch egative 62 Abbreviatios: CF Code of Federal egulatios; CPSC Cosumer Product Safety Commissio; FCA Freud s Complete Adjuvat; FSA Federal azardous Substaces Act; GPMT guiea pig maximizatio test; ET-CAM he s egg test chorioallatoic membrae; IPT huma repeated isult patch test; LLNA local lymph ode assay; ME microemulsio; ECD rgaisatio for Ecoomic Co-operatio ad Developmet; SDS sodium dodecyl sulfate

98 Distributed for Commet ly -- Do Not Cite or Quote Table 15 cular irritatio studies Test Article Cocetratio/Dose #/Aimals/Grp Method esults eferece ALTENATIVE STUDIES Polyglyceryl Mooesters Polyglyceryl-3 Laurate 10% i cor oil --- Epicular TM tissue model classified as o-irritatig ET 50 was >256 mi ME cotaiig 30% 100 µl 6 replicates ET-CAM assay; the test article also cotaied 1 or o-irritat Polyglyceryl-4 Laurate 2% lioleic acid, 4 or 5% isopropyl palmitate, ad 65% water-1,2-petaediol (1:9) or 63 or 65% water-1,2-petaediol (1.5:8.5) ME cotaiig 40% Polyglyceryl-4 Laurate 100 µl 6 replicates ET-CAM; this test article also cotaied 2% lioleic acid, 5% isopropyl palmitate, 53% water- 1,2-petaediol (1:9) 0.3 g # of replicates ot ET-CAM; CAM was rised with 5 ml stated physiological salie after 240 s of cotact ET-CAM; CAM was rised with 5 ml stated physiological salie after 240 s of cotact Apricot Kerel il Polyglyceryl- 4 Esters Palm il Polyglyceryl-4 Esters 0.3 g # of replicates ot Polyglyceryl-4 Laurate/Sebacate 30 µl Polyglyceryl-4 Laurate/Succiate 30 µl Polyglyceryl-6 Caprylate/Caprate huma coreal epithelial cells huma coreal epithelial cells 30 µl huma coreal epithelial cells o-irritat practically o-irritatig practically o-irritatig SkiEthic TM recostituted CE model; 10 mi cosidered to be o-irritat treatmet period, tissues were the rised; MTT was relative mea viability was 85.9% used to measure viability SkiEthic TM recostituted CE model; 10 mi cosidered to be o-irritat treatmet period, tissues were the rised; MTT was relative mea viability was 70.0% used to measure viability SkiEthic TM recostituted CE model; 10 mi cosidered to be o-irritat treatmet period, tissues were the rised; MTT was relative mea viability was 88.4% used to measure viability SIC-N (ot defied) o-irritat Polyglyceryl-10 Myristate 1000 mg/l (max) rabbit coreal epithelial cells Polyglyceryl-10 Stearate 1000 mg/l (max) rabbit coreal SIC-N (ot defied) o-irritat epithelial cells 60% Polyglyceryl-10 Eicosaedioate/ udiluted --- Epicular TM test o-irritat Tetradecaedioate/40% glyceri mixture Polyglyceryl Multi-Esters Polyglyceryl-2 Dioleate udiluted; 300 µl 6 eggs ET-CAM assay classified as o-irritatig Q-score <1.2 (up to 300 s) Diisostearoyl Polyglyceryl-3 Dimer Dilioleate ot stated ot stated ET-CAM assay mior irritatio Triisostearoyl Polyglyceryl-3 10% i cor oil --- Epicular TM tissue model classified as o-irritatig Dimer Dilioleate ET 50 was >256 mi Polyglyceryl-10 Diisostearate 1000 mg/l (max) rabbit coreal SIC-N (ot defied) o-irritat epithelial cells ANIMAL Polyglyceryl Mooesters Polyglyceryl-3 Caprate ot provided rabbits; # ot stated ECD 405 (acute eye irritatio/corrosio) ot irritatig a polyglyceryl moo/diester of ot provided rabbits; # ot stated ECD 405 (acute eye irritatio/corrosio) ot irritatig capric acid (C10) (provided as read-across for Polyglyceryl-3 Caprylate)

99 Distributed for Commet ly -- Do Not Cite or Quote Table 15 cular irritatio studies Test Article Cocetratio/Dose #/Aimals/Grp Method esults eferece Polyglyceryl-3 Isostearate ot provided rabbits;# ot stated FSA/CPSC 16 CF mildly irritatig 41 Polyglyceryl-3 leate ot provided rabbits;# ot stated FSA/CPSC 16 CF mildly irritatig 42 Polyglyceryl-4 Caprate ot provided rabbits; # ot stated ECD 405 (acute eye irritatio/corrosio) ot irritatig 43 Polyglyceryl Multi-Esters Polyglyceryl-2 Diisostearate udiluted, 0.1 ml 3 NZW rabbits ECD test guidelie 405 ot irritatig; some observatios were made at 24 h, but 33 eyes were rised after 24 h ad at all exams were fully reversible at 48 h Polyglyceryl-2 Diisostearate udiluted, 0.1 ml 6 NZW rabbits risig ot specified ot a primary eye irritat; at 24 h, 4 aimals had ijected 33 vessels ad 1 had swellig; at 48 h, 2 aimals had erythema ad 2 had swellig; o effects were see at 72 h Polyglyceryl-2 Diisostearate 0.1 ad 10% i salie ad udiluted; 0.1 ml eyes were rised after 24 h 33 2 Albio- imalaya- Kaiche rabbits/gp some ocular effects, icludig reddeig were observed at all cocetratios tested, but the results were ot quatified Polyglyceryl-2 Dioleate udiluted 3 rabbits risig ot specified ot irritatig; o sigs of irritatio were observed Polyglyceryl-3 Diisostearate ot stated; assumed to be 3 New Zealad ECD test guidelie 405 o-irritatig; at 1 h i aimals, chemosis (score of 1) udiluted albio rabbits ad redess (score of 2) were reported; at 72 h, chemosis was completely resolved ad the redess score was 1 1,2,3-propaetriol, homopolymer, diisooctadecaoate ( ot udiluted; 0.1 ml defied most likely Polyglyceryl- 3 Diisostearate) 4 male Kleirusse rabbits eyes were ot rised ot irritatig; at 24 h, very slight redess of the cojuctivae was observed i 1 aimal, ad the effect was reversible withi 48 h UMAN Polyglyceryl Mooesters Polyglyceryl-10 Laurate (~60% pure, with ~40% polyglyceri-10 ad ~2% sodium laurate) ot provided ot provided ot provided possibly slightly irritatig to the eyes Abbreviatios: CE huma coreal epithelium; ET-CAM - e's Egg Test Chorioallatoic Membrae; ME microemulsio; NZW New Zealad White; ECD rgaisatio for Ecoomic Co-operatio ad Developmet

100 Distributed for Commet ly -- Do Not Cite or Quote EFEENCES 1. Nikitakis J ad Breslawec P. Iteratioal Cosmetic Igrediet Dictioary ad adbook. 15 ed. Washigto, DC: Persoal Care Products Coucil, Johso Jr W, eldreth B, Bergfeld WF, Belsito DV, Klaasse CD, ill A, Liebler DC, Marks Jr JG, Shak C, Slaga TJ, Syder PW, ad Aderse FA. Fial eport of the Cosmetic Igrediet eview Expert Pael o the Safety Assessmet of Pelargoic Acid (Noaoic Acid) ad Noaoate Esters. It J Toxicol. 2011;30(Suppl 3):228S-269S Fiume MM, eldreth BA, Bergfeld WF, Belsito DV, ill A, Klaasse CD, Liebler DC, Marks Jr JG, Shak C, Slaga TJ, Syder PW, ad Gill LJ Fial Ameded eport of the Safety Assessmet of Mooglyceryl Mooesters as Used i Cosmetics. Available o the Cosmetic Igrediet eview website. 4. Europea Chemical Agecy (ECA). Iformatio o Chemicals. Last Updated Date Accessed Nor V. Polyglycerol esters. Emulsifiers Food Techol CAPLUS AN 2004: (Coferece; Geeral eview). 6. Dürr-Auster N. Doctor of Scieces. Formatio ad stability of a liquid foam prepared from a lamellar surfactat dispersio Switzerlad: Swiss Federal Istitute of Techology Zurich. ET Dissertatio Number Accessed asehuettl GL. Sythesis ad Commercial Preparatio of Food Emulsifiers. Chapter: 2. asehuettl GL ad artel W. I: Food Emulsifiers ad Their Applicatios. New York: Spriger; 2008: Food ad Agriculture rgaizatio (FA) of the Uited Natios. Polyglycerol Esters of Fatty Acids. Last Updated Date Accessed Food ad Drug Admiistratio (FDA). Frequecy of use of cosmetic igrediets. FDA Database Persoal Care Products Coucil Cocetratio of Use by FDA Product Category: Glyceryl Mooesters. Upublished data submitted by Persoal Care Products Coucil. 11. Persoal Care Products Coucil Cocetratio of Use by FDA Product Category: Polyglyceryl Esters. Upublished data submitted by Persoal Care Products Coucil. 1 pages. 12. Persoal Care Products Coucil Cocetratio of Use by FDA Product Category: Polyglyceryl Compouds icluded i the February 2015 Survey. Upublished data submitted by Persoal Care Products Coucil. 13. Persoal Care Products Coucil Cocetratio of use iformatio: polyglyceryl-10 hydroxystearate/stearate/eicosodioate. Upublished data submitted by the Persoal Care Products Coucil. 14. Persoal Care Products Coucil Cocetratio of Use by FDA Product Category: Caprylic/Capric Glycerides Polyglyceryl-10 Esters ad Pumpki Seed il Polyglyceryl-4 Esters Succiate. Upublished data submitted by Persoal Care Products Coucil. 15. Johse MA. The ifluece of particle size. Spray Techology ad Marketig. 2004;14(11): othe. Special Aspects of Cosmetic Spray Evalulatio Upublished data preseted at the 26 September CI Expert Pael meetig. Washigto, D.C. 17. Bremmer J, Prud'homme de Lodder LC, ad Egele JGM. Cosmetics Fact Sheet: To assess the risks for the cosumer; Updated versio for CosExpo eport No. IVM /2006. pp othe, Fautz, Gerber E, Neuma L, ettiger K, Schuh W, ad Groewold C. Special aspects of cosmetic spray safety evaluatios: Priciples o ihalatio risk assessmet. Toxicol Lett. 2011;205(2):

101 Distributed for Commet ly -- Do Not Cite or Quote 19. Europea Commissio. CosIg database; followig Cosmetic egulatio No. 1223/ Last Updated Date Accessed Natioal INdustrial Chemicals Notificatio ad Assessmet Scheme (NICNAS). File No. STD/1453. Public report: 1,2,3- Propaetriol, homopolymer, dodecaoate (CAS No ) data/assets/word_doc/0003/6096/std1453-f-final.docx. Date Accessed eport No. File No: STD/ World ealth rgaizatio (W). Evaluatio of certai food additives ad cotamiats. Thirty-fifth report of the Joit FA/W Expert Committe o Food Additives. W Techical eport Series (TS) Last Updated Date Accessed Food ad Agriculture rgaizatio (FA) of the Uited Natios. Polyglycerol esters of iteresterified ricioleic acid. Last Updated Date Accessed Europea Food Safety Authority (EFSA) Pael o Food Cotact Materials, Ezymes, Flavourigs ad Processig Aids (CEF Pael). Scietific piio o the safety assessmet of the substace, polyglycerol, CAS No , for use i food cotact materials. EFSA Joural. 2015;11(10): Loza. Product data sheet: Polyaldo 10-1 CC KFG (Polyglyceryl-10 Caprylate/Caprate). CC_KFG_NN_GM_PDS.pdf. Last Updated Date Accessed ChemicalBook. Polyglyceryl-10 leate. Last Updated Date Accessed Gattefossé. Plurol leique CC 497 (Polyglyceryl-3 Dioleate). Last Updated Date Accessed World ealth rgaizatio (W). Toxicological evaluatio of some atimicrobials, atioxidats, emulsifiers, stablizers, flourtreamet agets, acids ad bases. Polyglycerol esters of fatty acids Date Accessed eport No. eport Series No. 40A, B, C; W/Food Add./ Bodasky M, errma CL, ad Campbell K. CCXLIX. Utliizatio of polyglycerol esters. Biochem J. 1938;32(11): Babaya VK, Kauitz, ad Slaetz CA. Nutritioal studies of polyglycerol esters. Joural of the America il Chemists' Society. 1964;41(6): World ealth rgaizatio (W). Toxicological evaluatio of some food additives icludig aticakig agets, atimicrobials, atioxidats, emulsifiers ad thickeig agets. Polyglycerol esters of fatty acids Date Accessed eport No. W Food Additives Series No Michael W ad Coots. Metabolism of polyglycerol ad polyglycerol esters. Toxicol Appl Pharmacol. 1971;20(3): Kig W, Michael W, ad Coots. Subacute oral toxicity of polyglycerol ester. Toxicol Appl Pharmacol. 1971;20(3): Europea Chemicals Agecy (ECA). Di(isooctadecaoic) acid, diester with oxydi(propaediol) (CAS No ). Last Updated Date Accessed Corwell PA, Tubek J, va Gompel AP, Little CJ, ad Wiechers JW. Glyceryl moocaprylate/caprate as a moderate ski peetratio ehacer. Iteratioal Joural of Pharmaceutics. 1998;171(2): Sahle FF, Metz, Wohlrab J, ad Neubert. Polyglycerol fatty acid ester surfactat-based microemulsios for targeted delivery of ceramide AP ito the stratum coreum: formulatio, characterisatio, i vitro release ad peetratio ivestigatio. Eur J Pharm Biopharm. 2012;82(1): Sahle FF, Wohlrab J, ad Neubert. Cotrolled peetratio of ceramides ito ad across the stratum coreum usig various types of microemulsios ad formulatio associated toxicity studies. Eur J Pharm Biopharm. 2014;86(2):

102 Distributed for Commet ly -- Do Not Cite or Quote 37. Edo M, Yamamoto T, ad IjuiT. Effect of oioic surfactats o the percutaeous absorptio teoxicam. Chem Pharm Bull (Tokyo). 1996;44(4): Europea Chemicals Agecy (ECA). 1,2,3-Propaetriol, homopolymer, diisooctadecaoate (CAS No ). Last Updated Date Accessed Aoymous Polyglyceryl-3 Caprate: Summary of product data with referece to toxicology. Upublished data submitted by Persoal Care Products Coucil. 40. Aoymous Polyglyceryl-3 Caprylate: Summary of product data with referece to toxicology. Upublished data submitted by Persoal Care Products Coucil. 41. Aoymous Polyglyceryl-3 Isostearate: Summary of product data with referece to toxicology. Upublished data submitted by Persoal Care Products Coucil. 42. Aoymous Polyglyceryl-3 leate: Summary of product data with referece to toxicology. Upublished data submitted by Persoal Care Products Coucil. 43. Aoymous Polyglyceryl-4 Caprate: Summary of product data with referece to toxicology. Upublished data submitted by Persoal Care Products Coucil. 44. Europea Chemicals Agecy (ECA). leic acid, mooester with oxybis(propaediol (CAS No ). Last Updated Date Accessed Aoymous Summary iformatio Palm il Polyglyceryl-4 Esters, Apricot Kerel il Polyglyceryl-4 Esters ad Polyglyceryl-3 Diisostearate. Upublished data submitted by Persoal Care Products Coucil. 46. Aoymous Diisostearoyl Polyglyceryl-3 Dimer Dilioleate: Summary of product data with referece to toxicology. Upublished data submitted by Persoal Care Products Coucil. 47. Lubrizol. Toxicology & Microbiology Studies (TX-104): Schercemol PTID Ester( Triisostearoyl Polyglyceryl-3 Dimer Dilioleate) Schercemol%E2%84%A2-PTID-Ester.pdf. Last Updated Date Accessed Lubrizol Advaced Materials Schercemol PDD Ester (Diisostearoyl Polyglyceryl-3 Dimer Dilioleate) toxicology studies. Upublished data submitted by Persoal Care Products Coucil. 49. Baichwal M ad Lalla JK. Polyglycerol esters. III. Stability, toxicity, ad compatibility of polyglycerol stearate with pharmaceutical adjuvats. Idia Joural of Pharmacy. 1973;35(5): Lubrizol Advaced Materials Summary iformatio polyglyceryl fatty acid esters. Upublished data submitted by Persoal Care Products Coucil. 51. arla Laboratories, Ltd Summary: everse mutatio assay "Ames test" usig Salmoella typhimurium ad Escherichia coli (Polyglyceryl-4 Laurate/Succiate). Project No. 4100/3617. Upublished data submitted by Persoal Care Products Coucil. 52. arla Laboratories, Ltd Summary: everse mutatio assay "Ames test" usig Salmoella typhimurium ad Escherichia coli (Polyglyceryl-6 Caprylate/Caprate). Project No Upublished data submitted by Persoal Care Products Coucil. 53. arla Laboratories, Ltd. Summary: Determiatio of ski irritatio potetial usig the Episki recostituted huma epidermis model (Polyglyceryl-4 Laurate/Sebacate). Project No. 2724/ Upublished data submitted by Persoal Care Products Coucil. 54. arla Laboratories, Ltd Summary: Determiatio of ski irritatio potetial usig the Episki recostituted huma epidermis model (Polyglyceryl-4 Laurate/Succiate). Project No. 2724/0055. Upublished data submitted by Persoal Care Products Coucil. 55. arla Laboratories, Ltd Summary: Determiatio of ski irritatio potetial usig the Episki recostituted huma epidermis model (Polyglyceryl-6 Caprylate/Caprate). Project No. 2724/0057. Upublished data submitted by Persoal Care Products Coucil.

103 Distributed for Commet ly -- Do Not Cite or Quote 56. Notox BV. Primary ski irritatio/corrosiostudy with Polyglyeryl-2 Isostearate i the rabbit eport No. NTX Project Upublished data submitted by Persoal Care Products Coucil. 57. Globecrow Services Ltd. A three-applicatio patch trial i healthy voluteers to ivestigate the ski irritatio potetial of Polyglyceryl-2 Isostearate followig cutaeous patch applicatios. Globecrow eport No. 97/UNCPAT Upublished data submitted by Persoal Care Products Coucil. 58. Nikko Chemicals Co. Ltd Safety iformatio NIKKL Decagly 1-M (Polyglyceryl-10 Myristate). Upublished data submitted by Persoal Care Products Coucil. 59. Nikko Chemicals Co. Ltd Safety iformatio NIKKL Decagly 1-SV (Polyglyceryl-10 Stearate). Upublished data submitted by Persoal Care Products Coucil. 60. Aoymous Material safety data sheet o a trade ame mixture cotaiig 60% Polyglyceryl-10 Eicosaedioate/Tetradecaedioate. Upublished data submitted by Persoal Care Products Coucil. 61. Nikko Chemicals Co. Ltd Safety iformatio NIKKL Decagly 5-IS (Polyglyceryl-10 Petaisostearate). Upublished data submitted by Persoal Care Products Coucil. 62. Nikko Chemicals Co. Ltd Safety iformatio NIKKL Decagly 10- (Polyglyceryl-10 Decaoleate). Upublished data submitted by Persoal Care Products Coucil. 63. Lubrizol. Toxicology studies (TX-094): ydramol TGL Ester (Polyglyceryl-3 Laurate). Care/Documets/Toxicological-ad-Microbiological-Studies/TX-094-ydramol%E2%84%A2-TGL-Ester.pdf. Last Updated Date Accessed arla Laboratories, Ltd Summary: Assessmet of ocular irritatio potetial usid the Skiethic recocsituted huma coreal epithelium model (Polyglyceryl-4 Laurate/Sebacate). Project No. 2724/0059. Upublished data submitted by Persoal Care Products Coucil. 65. arla Laboratories, Ltd Summary: Assessmet of ocular irritatio potetial usig the Skiethic recostituted huma coreal epithelium model (Polyglyceryl-4 Laurate/Succiate). Project No. 2724/0058. Upublished data submitted by Persoal Care Products Coucil. 66. arla Laboratories, Ltd Summary: Assessmet of ocular irritatio potetial usig the Skiethic recosituted huma coreal epithelium modole. Project o. 2724/0060. Upublished data submitted by Persoal Care Products Coucil. 67. Nikko Chemicals Co. Ltd Safety iformatio NIKKL Decagly 2-ISV (Polyglyceryl-10 Diisostearate). Upublished data submitted by Persoal Care Products Coucil. 68. Washizaki K, Kato, Yazaki S, ad Ito M. A case of allergic cotact dermatitis to polyglyceryl laurate. Cotact Dermatitis. 2008;58(3): Becker LC, Bergfeld WF, Belsito DV, ill A, Klaasse CD, Liebler DC, Marks JG Jr, Shak C, Slaga TJ, Syder PW, ad Gill LJ. Safety assessmet of glyceri as used i cosmetics Date Accessed Available o the CI website. 70. Elder L (ed). Fial eprt o the Safety Assessmet of Butylee Glycol, exylee Glycol, Ethoxydiglycol, ad Dipropylee Glycol. J Am Coll Toxicol. 1985;4(5): Aderse FA (ed). Aual eview of Cosmetic Igrediet Safety Assessmets /2005. It J Toxicol. 2006;25(Suppl 2): Fiume MM, eldreth BA, Bergfeld WF, Belsito DV, ill A, Klaasse CD, Liebler DC, Marks JG Jr, Shak C, Slaga TJ, Syder PW, ad Aderse FA. Safety Assessmet of Propylee Glycol, Tripropylee Glycol, ad PPGs as Used i Cosmetics. It J Toxicol. 2012;31(Suppl 2):245S-260S. 73. Johso WJ Jr, eldreth BA, Bergfeld WF, Belsito DV, ill A, Klaasse CD, Liebler DC, Marks JG Jr, Shak C, Slaga TJ, Syder PW, ad Gill LJ Fial eport o the Safety Assessmet of Polysaccharide Gums as Used i Cosmetics. Available o the CI website.

104 Distributed for Commet ly -- Do Not Cite or Quote 74. Becker LC, Bergfeld WF, Belsito DV, ill A, Klaasse CD, Marks JG Jr, Shak C, Slaga TJ, Syder PW, ad Aderse FA. Fial eport o the Ameded Safety Assessmet of Myrisitic Acid ad Its Salts ad Esters as Used i Cosmetics. It J Toxicol. 2010;29(Suppl 3):162S-186S. 75. Fiume MM, eldreth BA, Bergfeld WF, Belsito DV, ill A, Klaasse CD, Liebler DC, Marks JG Jr, Shak C, Slaga TJ, Syder PW, ad Aderse FA. Safety assessmet of citric acid, iorgaic citrate salts, ad alkyl citrate esters as used i cosmetics. It J Toxicol. 2014;33(Suppl 2):16S-46S Burett CL, Bergfeld WF, Belsito DV, Klaasse CD, Marks JG Jr, Shak C, Slaga TJ, Syder PW, ad Aderse FA. Fial report o the safety assessmet of Cocos ucifera (cocout) oil ad related igrediets. It J Toxicol. 2011;30(Suppl 1):5S-16S Aderse FA (ed). Ameded fial report o the safety assessmet of hydroxystearic acid. It J Toxicol. 1999;18(Suppl 1): Elder L (ed). Fial report o the safety assessmet of isostearic acid. J Am Coll Toxicol. 1983;2(7): Elder L (ed). Fial report o the safety assessmet of oleic acid, lauric acid, palmitic acid. myristic acid, ad stearic acid. J Am Coll Toxicol. 1987;6(3): Burett CL, Fiume MM, Bergfeld WF, Belsito DV, ill A, Klaasse CD, Liebler DC, Marks JG Jr, Shak C, Slaga TJ, Syder PW, ad Aderse FA Fial report o the safety assessemet of plat-derived fatty acid oils as used i cosmetics. Available o the CI website. 81. Aderse FA (ed). Fial eport o the Safety Assessmet of icius Commuis (Castor) Seed il, ydrogeated Castor il, Glyceryl icioleate, Glyceryl icioleate SE, icioleic Acid, Potassium icioleate, Sodium icioleate, Zic icioleate, Cetyl icioleate, Ethyl icioleate, Glycol icioleate, Isopropyl icioleate, Methyl icioleate, ad ctyldodecyl icioleate. It J Toxicol. 2007;26(Suppl 3): Fiume MM, eldreth BA, Bergfeld WF, Belsito DV, ill A, Klaasse CD, Liebler DC, Marks JG Jr, Shak C, Slaga TJ, Syder PW, ad Aderse FA. Fial report of the Cosmetic Igrediet eview Expert Pael o the safety assessmet of dicarboxylic acids, salts, ad esters. It J Toxicol. 2012;31(Suppl 1):5S-76S Elder L (ed). Fial eport of the Safety Assessmet of Lithium Stearate, Alumium Distearate, Alumium Stearate, Alumium Tristearate, Ammoium Stearate, Calcium Stearate, Magesium Stearate, Potassium Stearate, Sodium Stearate, ad Zic Stearate. J Am Coll Toxicol. 2016;1(2): Aderse FA (ed). Aual eview of Cosmetic Igrediet Safety Assessmets /2002. It J Toxicol. 2003;22(Suppl 1): Aderse FA (ed). Fial report o the safety assessmet of Acacia Catechu Gum, Acacia Cocia Fruit Extract, Acacia Dealbata Leaf Extract, Acacia Dealbata Leaf Wax, Acacia Decurres Extract, Acacia Faresiaa Extract, Acacia Faresiaa Flower Wax, Acacia Faresiaa Gum, Acacia Seegal Extract, Acacia Seegal Gum, ad Acacia Seegal Gum Extract. It J Toxicol. 2005;24(Suppl 3): Elder L (ed). Fial eport o the safety assessmet of Cadelilla Wax, Carauba Wax, Japa Wax, ad Beeswax. J Am Coll Toxicol. 1984;3(3): Aderse FA (ed). Aual eview of Cosmetic Igrediet Safety Assessmets /2003. It J Toxicol. 2005;24(Suppl 1): Aderse FA (ed). Ameded Fial eport o the Safety Assessmet of ryza Sativa (ice) Bra il, ryza Sativa (ice) Germ il, ice Bra Acid, ryza Sativa (ice) Bra Wax, ydrogeated ice Bra Wax, ryza Sativa (ice) Bra Extract, ryza Sativa (ice) Extract, ryza Sativa (ice) Germ Powder, ryza Sativa (ice) Starch, ryza Sativa (ice) Bra, ydrolyzed ice Bra Extract, ydrolyzed ice Bra Protei, ydrolyzed ice Extract, ad ydrolyzed ice Protei. It J Toxicol. 2006;25(Suppl 2): Becker LC, Bergfeld WF, Belsito DV, Klaasse CD, Marks JG Jr, Shak C, Slaga TJ, Syder PW, ad Aderse FA Safety Assessmet of Simmodsia Chiesis (Jojoba) Seed il, Simmodsia Chiesis (Jojoba) Seed Wax, ydrogeated Jojoba il, ydrolyzed Jojoba Esters, Isomerized Jojoba il, Jojoba Esters, Simmodsia Chiesis (Jojoba) Butter, Jojoba Alcohol, ad Sythetic Jojoba il. Available o the Cosmetic Igrediet eview website.

105 Distributed for Commet ly -- Do Not Cite or Quote 90. Aldivia. Techical Data Sheet: VIATENZA Baobab P6 (Adasoia Digitata Seed il Polyglyceryl-6 Esters). Last Updated Date Accessed Aldivia. Data sheet: VIATENZA Apricot P6 (Apricot Kerel il Polyglyceryl-6 Esters ). Last Updated Date Accessed Aldivia. Data Sheet: VIATENZA Apricot P10 (Apricot Kerel il Polyglyceryl-10 Esters). Last Updated Date Accessed Aldivia. Techical Data Sheet: VIATENZA Arga P6 (Arga il Polyglyceryl-6 Esters). Last Updated Date Accessed Aldivia. Techical Data Sheet: VIATENZA Babassu P6 (Babassu il Polyglyceryl-6 Esters). Last Updated Date Accessed Aldivia. Techical data sheet: VIATENZA Brazil Nut P6 (Bertholletia Excelsa Seed il Polyglyceryl-6 Esters). Last Updated Date Accessed Aldivia. Data Sheet: VIATENZA Caprylic/Capric P10 (Caprylic/Capric Glycerides Polyglyceri-10 Esters). Last Updated Date Accessed Abitec. Techical Data Sheet: VIATENZA Cocoa P6 (Cocoa butter Polyglyceryl-6 Esters). Last Updated Date Accessed Aldivia. Techical Data Sheet: VIATENZA Coco P6 (Cocout il Polyglyceryl-6 Esters). Last Updated Date Accessed Aldivia. Techical data sheet: VIATENZA azel P6 (azel Seed il Polyglyceryl-6 Esters). Last Updated Date Accessed Aldivia. Techical data sheet: VIATENZA Macadamia P6 (Macadamia Seed il Polyglyceryl-6 Esters) pdf. Last Updated Date Accessed Aldivia. Techical data sheet: VIATENZA live P6 (live il Polyglyceryl-6 Esters). Last Updated Date Accessed Aldivia. Techical data sheet: VIATENZA Safflower P6 (Safflower il Polyglyceryl-6 Esters). Last Updated Date Accessed Aldivia. Techical data sheet: VIATENZA Mogogo P6 (Schiziophyto autaeii Kerel il Polyglyceryl-6 Esters) pdf. Last Updated Date Accessed Aldivia. Techical data sheet: VIATENZA Marula P6 (Sclerocarya Birrea Seed il Polyglyceryl-6 Esters). Last Updated Date Accessed Aldivia. Techical data sheet: VIATENZA Sesame P6 (Sesame il Polyglyceryl-6 Esters). Last Updated Date Accessed

106 Distributed for Commet ly -- Do Not Cite or Quote 106. Aldivia. Techical data sheet: VIATENZA Shea P6 (Shea Butter Polyglyceryl-6 Esters). Last Updated Date Accessed Aldivia. Techical data sheet: VIATENZ A Soybea P06 (Soybea il Polyglyceryl-6 Esters). Last Updated Date Accessed Aldivia. Techical data sheet: VIATENZA leic Suflower P6 (Suflower Seed il Polyglyceryl-6 Esters). Last Updated Date Accessed Aldivia. Techical data sheet: VIATENZA leic Suflower P10 (Suflower Seed il Polyglyceryl-10 Esters ). Last Updated Date Accessed Aldivia. Techical data sheet: VIATENZA Almod P6 (Sweet Almod il Polyglyceryl-6 Esters ). Last Updated Date Accessed Aldivia. Techical data sheet: VIATENZA Mafura P6 (Trichilia Emetica Seed il Polyglyceryl-6 Esters). Last Updated Date Accessed AVG Pharma. P6 Viateza Borage (Borage Seed il Polyglyceryl-6 Esters). Last Updated Date Accessed Lubrizol. Techical data sheet (TDS-399): Schercemol PDD Ester (Diisostearoyl Polyglyceryl-3 Dimer Dilioleate). Ester.pdf. Last Updated Evoik Idustries. Techical Data Sheet: Isola PDI (Diisotearoyl Polyglyceryl-3 Dimer Dilioleate). Last Updated Date Accessed Stepheso Persoal Care. Durosoft. Last Updated Date Accessed Koster Keue. Techical data sheet: Cera Bellia (Polyglyceryl-3 Beeswax). f. Last Updated Date Accessed ChemNet ; Polyglyceryl-2 Caprate. CAPATE.html. Last Updated Date Accessed Evoik Idustries. TEG Cosmo P 813 (Polyglyceryl-3 Caprylate). Last Updated Date Accessed Loza. Product iformatio: Polyaldo 10-1-CC KFG (Polyglyceryl-10 Caprylate/Caprate) [pamphlet] Nikko Chemicals co., Ltd. Material Safety Data Sheet: NIKKL Decagly 10-ISV (Polyglyceryl-10 Decaisostearate). Last Updated Date Accessed AIC. Specificatio Sheet: Polyglyceryl-4 Caprate (SLDC PG 410 ). 4%20Caprate%20Soldoc%20PG%20410%20PG410L.pdf. Last Updated Date Accessed Evoik Idustries. TEGSFT PC 41 (Polyglyceryl-4 Caprate). Last Updated Date Accessed Nihoh Emulsio Co., Ltd. Product iformatio: Emalex DISG-6 (Polyglyceryl-6 Diisostearate). Last Updated Date Accessed

107 Distributed for Commet ly -- Do Not Cite or Quote 124. Uited States Pharmacopeial Covetio. Material Safety Data Sheet: Polyglyceryl-3 Dioleate. Last Updated Date Accessed Sigma-Aldrich. Polyglyceryl-6 Dioleate. 5&iterface=CAS%20No.&N=0+&mode=partialmax&lag=e&regio=US&focus=product. Last Updated Date Accessed U.S. Natioal Library of Medicie (NLM). ChemID Plus. Last Updated Date Accessed Loza. Iformatio brochure: Aldo ad Polyaldo Specific Emulsifier Solutio for All Types of Formulatios [pamphlet] BASF. Techical Iformatio: Cremophor GS 32 (Polyglyceryl-3 Distearate). Last Updated Date Accessed Parchem. Data sheet. Polyglyceryl-10 Distearate. Last Updated Date Accessed FTA Global. Polyglyceryl isopalmitate/sebacate. Last Updated Date Accessed ChemNet ; Isooctadecaoic acid, ester with oxybis[propaediol] (polyglyceryl-2 isostearate). Last Updated Date Accessed Goldschmidt AG. ISLAN GI 34 (Polyglyceryl-4 Isostearate). Last Updated Date Accessed The Good Scets Compay. Polyglyceryl-6 Distearate. Last Updated Date Accessed Loza. Iformatio pamphlet: Polyaldo GDS KFG (6-2-S) (Polyglyceryl-6 Distearate) [pamphlet] Lubrizol. Techical data sheet (TDS-371): ydramol TGL Ester (Polyglyceryl-3 Laurate). Ester.pdf. Last Updated Date Accessed Baret Products Corporatio. Product sepecificatios: Decagly 1-M (polyglyceyrl-10 myristate; CAS No ). Last Updated Date Accessed Evoik Idustries. TEG Care PL 4 (Polyglyceryl-4 Laurate). Last Updated Date Accessed Evoik Idustries. ISLAN G 33 (Polyglyceryl-3 leate). Last Updated Date Accessed Aoymous Compositio ad physical ad chemical properties Polyglyceryl-4 leate. Upublished data submitted by Persoal Care Products Coucil The Good Scets Compay. Polyglyceryl-10 leate. Last Updated Date Accessed Loza. Iformatio brochure: Polyaldo KFG (NN GM) (Polyglyceryl-10 leate) [pamphlet] SAAPedia. Polyglyceryl palmate. Last Updated Date Accessed SAAPedia. Polyglyceryl petacaprylate. Last Updated Date Accessed Stepa. NEBEE Medium Chai Triglycerides, WECBEE Triglycerides, DEWPL Polyglycerol Esters, ad DEWMULSE Moo ad Diglcyerides.

108 Distributed for Commet ly -- Do Not Cite or Quote px%3fid%3d1459+&cd=6&hl=e&ct=clk&gl=us. Last Updated Date Accessed Medolla. Techical datasheet: livatis 12 (Polyglyceryl-3 Petaolivate). Last Updated Date Accessed Nikko Chemicals Co. Ltd. Safety Data Sheet: NIKKL Decagly 5-V (Polyglyceryl-10 Petaoleate). Last Updated Date Accessed Nikko Chemicals Co. Ltd. Product Details: NIKKL Decagly 5-V (Polyglyceryl-10 Petaoleate). Last Updated Date Accessed Nikko Chemicals Co. Ltd. Product Details: NIKKL Tetragly 5-S (Polyglyceryl-4 Petastearate). Last Updated Date Accessed Parchem. Specificatios: Polyglyceryl-6 Petastearate. Last Updated Date Accessed Dowi Chemical. Polyglyceryl-6 Petastearate ( ). Last Updated Date Accessed Nikko Chemicals Co. Ltd. Product Details: NIKKL Decagly 5-SV (Polyglyceryl-10 Petastearate). Last Updated Date Accessed The Good Scets Compay. Polyglyceryl-10 Petastearate. Last Updated Date Accessed Progressus s.r.l Material safety data sheet PLIX B (Polyglyceryl-3 ice Braate). Upublished data submitted by Persoal Care Products Coucil AAK. Product iformatio: Akolie PGP (Polyglyceryl-3 icioleate). Last Updated Date Accessed Dr. Straetmas Chemische Produkte Gmb. Product iformatio: dermofeel G (Polyglyceryl-2 Sesquioleate). Last Updated Date Accessed SAAPedia. Polyglyceryl soyate/shea butterate. Last Updated Date Accessed Nisshi illi Group Ltd. aw materials for the cosmetics idustry. Last Updated Date Accessed Nikko Chemicals Co. Ltd. Product Details: Nikkol Decagly 1-SV (Polyglyceryl-10 Stearate). Last Updated Date Accessed Abitec. Material Safety Data Sheet: Caprol 10G40 (Polyglyceryl-10 Tetraoleate; CAS No ). Last Updated Date Accessed U.S. Evirometal Protectio Agecy (EPA). Substace Details - ctadecaoic acid, tetraester with oxybis[propaediol]. N&p_value= Last Updated Date Accessed Nihoh Emulsio Co., Ltd. Material Safety Data Sheet: Emalex TCCG-10 (Polyglyceryl-10 Tricocoate). Last Updated Date Accessed SAAPedia. Polyglyceryl tridecaoate. Last Updated Date Accessed Nihoh Emulsio Co., Ltd. Material Safety Data Sheet: Emalex TISG-10 (Polyglyceryl-10 Triisostearate). Last Updated Date Accessed

109 Distributed for Commet ly -- Do Not Cite or Quote 164. Nihoh Emulsio Co., Ltd. Product ifo: Emalex TISG-10 (Polyglyceryl-10 Triisostearate). Last Updated Date Accessed Nikko Chemicals Co. Ltd. Product Details: NIKKL Decagly 3-V (Polyglyceryl-10 Trioleate). Last Updated Date Accessed Nikko Chemicals Co. Ltd. Product Details: NIKKL Decagly 3-SV (Polyglyceryl-10 Tristearate). Last Updated Date Accessed Progressus s.r.l Material safety data sheet PLIX (ice Brai il Polyglyceryl-3 Esters). Upublished data submitted by Persoal Care Products Coucil Progressus. Prolix (ice Bra il Polyglyceryl-3 Ester). Last Updated Date Accessed Lubrizol. Product Specificatios: Schercemol PTID Ester (Triisostearoyl Polyglycerol-3 Dimer Dilioleate). Last Updated Date Accessed Lubrizol. Techical data sheet (TDS-403): Schercemol PTID Ester (Triisostearoyl Polyglyceryl-3 Dimer Dilioleate). PTID-Ester.pdf. Last Updated Date Accessed AVG Persoal Care. Viateza Ximeia P6 (Ximeia Americaa Seed il Polyglyceryl-6 Esters). YTY1NjUyZDUtZDgwMS00NzhlLWJiTYtZTM3NTAxGZiZDlmb58x4ypbPeWwG0KtXbz4s8jaQ1%29S%28 gxx5te45ak1x045cte4xt2b%29%29/attivo.aspx%3factiveid%3d117%26fuctioid%3d123%26productid%3d20 %26CategoryID%3D10&prev=search. Last Updated Date Accessed Gattefossé. Plurol Stearique WL 1009 (Polyglyceryl-6 Distearate) html. Last Updated Date Accessed Gattefossé. ydracire S. Last Updated Date Accessed CEME LE Gmb & Co. KG. CremerC PG4 Cocoate (Polyglyceryl-4 Cocoate). Last Updated Date Accessed Vatage Specialty Igrediets. Neosolue -Aqua (Polyglyceryl-10 Eicosaedioate/Tetradecaedioate). Last Updated Date Accessed

110 Distributed for Commet ly -- Do Not Cite or Quote Polyglyceryl Fatty Acid Esters FDA VCP ACACIA DECUENS/JJBA/SUNFLWE SEED WAX/PLYGLYCEYL-3 ESTES 03B - Eyelier 1 ACACIA DECUENS/JJBA/SUNFLWE SEED WAX/PLYGLYCEYL-3 ESTES 07A - Blushers (all types) 2 ACACIA DECUENS/JJBA/SUNFLWE SEED WAX/PLYGLYCEYL-3 ESTES 07E - Lipstick 1 ACACIA DECUENS/JJBA/SUNFLWE SEED WAX/PLYGLYCEYL-3 ESTES 07I - ther Makeup Preparatios 1 ACACIA DECUENS/JJBA/SUNFLWE SEED WAX/PLYGLYCEYL-3 ESTES 10E - ther Persoal Clealiess Products 1 ACACIA DECUENS/JJBA/SUNFLWE SEED WAX/PLYGLYCEYL-3 ESTES 12C - Face ad Neck (exc shave) 1 ACACIA DECUENS/JJBA/SUNFLWE SEED WAX/PLYGLYCEYL-3 ESTES 12D - Body ad ad (exc shave) 1 ACACIA DECUENS/JJBA/SUNFLWE SEED WAX/PLYGLYCEYL-3 ESTES 12F - Moisturizig 2 BABASSU IL PLYGLYCEYL-4 ESTES 05F - Shampoos (o-colorig) 17 BABASSU IL PLYGLYCEYL-4 ESTES 12A - Cleasig 1 BABASSU IL PLYGLYCEYL-6 ESTES 12A - Cleasig 1 CANDELILLA/JJBA/ICE BAN PLYGLYCEYL-3 ESTES 01B - Baby Lotios, ils, Powders, ad Cream 1 CANDELILLA/JJBA/ICE BAN PLYGLYCEYL-3 ESTES 03D - Eye Lotio 2 CANDELILLA/JJBA/ICE BAN PLYGLYCEYL-3 ESTES 03G - ther Eye Makeup Preparatios 4 CANDELILLA/JJBA/ICE BAN PLYGLYCEYL-3 ESTES 07C - Foudatios 1 CANDELILLA/JJBA/ICE BAN PLYGLYCEYL-3 ESTES 07E - Lipstick 1 CANDELILLA/JJBA/ICE BAN PLYGLYCEYL-3 ESTES 12C - Face ad Neck (exc shave) 2 CANDELILLA/JJBA/ICE BAN PLYGLYCEYL-3 ESTES 12D - Body ad ad (exc shave) 1 CANDELILLA/JJBA/ICE BAN PLYGLYCEYL-3 ESTES 12F - Moisturizig 2 CANDELILLA/JJBA/ICE BAN PLYGLYCEYL-3 ESTES 12G - Night 2 CCNUT IL PLYGLYCEYL-6 ESTES 10E - ther Persoal Clealiess Products 1 CCNUT IL PLYGLYCEYL-6 ESTES 12A - Cleasig 1 DIISSTEAYL PLYGLYCEYL-3 DIME DILINLEATE 03C - Eye Shadow 1 DIISSTEAYL PLYGLYCEYL-3 DIME DILINLEATE 12G - Night 2 GLYCEYL/PLYGLYCEYL-6 ISSTEAATE/BEENATE ESTES 03B - Eyelier 1 GLYCEYL/PLYGLYCEYL-6 ISSTEAATE/BEENATE ESTES 03C - Eye Shadow 1 GLYCEYL/PLYGLYCEYL-6 ISSTEAATE/BEENATE ESTES 07A - Blushers (all types) 1 GLYCEYL/PLYGLYCEYL-6 ISSTEAATE/BEENATE ESTES 07C - Foudatios 2 GLYCEYL/PLYGLYCEYL-6 ISSTEAATE/BEENATE ESTES 07E - Lipstick 2 GLYCEYL/PLYGLYCEYL-6 ISSTEAATE/BEENATE ESTES 12D - Body ad ad (exc shave) 1 GLYCEYL/PLYGLYCEYL-6 ISSTEAATE/BEENATE ESTES 12J - ther Ski Care Preps 2 MACADAMIA SEED IL PLYGLYCEYL-6 ESTES BEENATE 03C - Eye Shadow 1 MACADAMIA SEED IL PLYGLYCEYL-6 ESTES BEENATE 03F - Mascara 1 MACADAMIA SEED IL PLYGLYCEYL-6 ESTES BEENATE 03G - ther Eye Makeup Preparatios 1 MACADAMIA SEED IL PLYGLYCEYL-6 ESTES BEENATE 13A - Suta Gels, Creams, ad Liquids 1 PALM IL PLYGLYCEYL-4 ESTES 12D - Body ad ad (exc shave) 1 PLYGLYCEYL-10 BEENATE/EICSADIATE 12A - Cleasig 1 PLYGLYCEYL-10 BEENATE/EICSADIATE 12J - ther Ski Care Preps 1 PLYGLYCEYL-10 DECALEATE 07C - Foudatios 1 PLYGLYCEYL-10 DECALEATE 07E - Lipstick 3 PLYGLYCEYL-10 DECALEATE 07F - Makeup Bases 1 PLYGLYCEYL-10 DECALEATE 12F - Moisturizig 4 PLYGLYCEYL-10 DECALEATE 12J - ther Ski Care Preps 1

111 Distributed for Commet ly -- Do Not Cite or Quote Polyglyceryl Fatty Acid Esters FDA VCP PLYGLYCEYL-10 DIISSTEAATE 07F - Makeup Bases 1 PLYGLYCEYL-10 DIISSTEAATE 12A - Cleasig 1 PLYGLYCEYL-10 DIISSTEAATE 12C - Face ad Neck (exc shave) 4 PLYGLYCEYL-10 DIISSTEAATE 12F - Moisturizig 3 PLYGLYCEYL-10 DIPALMITATE 02A - Bath ils, Tablets, ad Salts 2 PLYGLYCEYL-10 DIPALMITATE 07E - Lipstick 1 PLYGLYCEYL-10 DIPALMITATE 10E - ther Persoal Clealiess Products 9 PLYGLYCEYL-10 DIPALMITATE 12A - Cleasig 2 PLYGLYCEYL-10 DIPALMITATE 12C - Face ad Neck (exc shave) 1 PLYGLYCEYL-10 DIPALMITATE 12 - Paste Masks (mud packs) 1 PLYGLYCEYL-10 DIPALMITATE 12J - ther Ski Care Preps 1 PLYGLYCEYL-10 DISTEAATE 10E - ther Persoal Clealiess Products 1 PLYGLYCEYL-10 DISTEAATE 12F - Moisturizig 9 PLYGLYCEYL-10 YDXYSTEAATE/STEAATE/EICSADIATE 07I - ther Makeup Preparatios 1 PLYGLYCEYL-10 YDXYSTEAATE/STEAATE/EICSADIATE 12A - Cleasig 1 PLYGLYCEYL-10 ISSTEAATE 12F - Moisturizig 3 PLYGLYCEYL-10 LAUATE 01A - Baby Shampoos 2 PLYGLYCEYL-10 LAUATE 01C - ther Baby Products 4 PLYGLYCEYL-10 LAUATE 03B - Eyelier 1 PLYGLYCEYL-10 LAUATE 03D - Eye Lotio 2 PLYGLYCEYL-10 LAUATE 03G - ther Eye Makeup Preparatios 2 PLYGLYCEYL-10 LAUATE 05A - air Coditioer 2 PLYGLYCEYL-10 LAUATE 05I - ther air Preparatios 1 PLYGLYCEYL-10 LAUATE 07I - ther Makeup Preparatios 2 PLYGLYCEYL-10 LAUATE 12A - Cleasig 4 PLYGLYCEYL-10 LAUATE 12C - Face ad Neck (exc shave) 9 PLYGLYCEYL-10 LAUATE 12F - Moisturizig 8 PLYGLYCEYL-10 LAUATE 12G - Night 2 PLYGLYCEYL-10 LAUATE 12I - Ski Fresheers 1 PLYGLYCEYL-10 LAUATE 12J - ther Ski Care Preps 4 PLYGLYCEYL-10 MYISTATE 01A - Baby Shampoos 1 PLYGLYCEYL-10 MYISTATE 03C - Eye Shadow 1 PLYGLYCEYL-10 MYISTATE 07I - ther Makeup Preparatios 1 PLYGLYCEYL-10 MYISTATE 12A - Cleasig 6 PLYGLYCEYL-10 MYISTATE 12C - Face ad Neck (exc shave) 3 PLYGLYCEYL-10 MYISTATE 12F - Moisturizig 2 PLYGLYCEYL-10 MYISTATE 13A - Suta Gels, Creams, ad Liquids 3 PLYGLYCEYL-10 MYISTATE 13B - Idoor Taig Preparatios 1 PLYGLYCEYL-10 NNAISSTEAATE 03C - Eye Shadow 18 PLYGLYCEYL-10 NNAISSTEAATE 03G - ther Eye Makeup Preparatios 5 PLYGLYCEYL-10 NNAISSTEAATE 07C - Foudatios 2 PLYGLYCEYL-10 NNAISSTEAATE 07E - Lipstick 26 PLYGLYCEYL-10 NNAISSTEAATE 07I - ther Makeup Preparatios 7 PLYGLYCEYL-10 LEATE 01A - Baby Shampoos 1 PLYGLYCEYL-10 LEATE 05A - air Coditioer 2 PLYGLYCEYL-10 LEATE 05F - Shampoos (o-colorig) 1 PLYGLYCEYL-10 LEATE 05G - Toics, Dressigs, ad ther air Groo 1

112 Distributed for Commet ly -- Do Not Cite or Quote Polyglyceryl Fatty Acid Esters FDA VCP PLYGLYCEYL-10 LEATE 11G - ther Shavig Preparatio Products 1 PLYGLYCEYL-10 LEATE 12C - Face ad Neck (exc shave) 5 PLYGLYCEYL-10 LEATE 12D - Body ad ad (exc shave) 2 PLYGLYCEYL-10 LEATE 12F - Moisturizig 6 PLYGLYCEYL-10 LEATE 12 - Paste Masks (mud packs) 2 PLYGLYCEYL-10 LEATE 12J - ther Ski Care Preps 2 PLYGLYCEYL-10 LEATE 13A - Suta Gels, Creams, ad Liquids 3 PLYGLYCEYL-10 PENTAYDXYSTEAATE 03F - Mascara 1 PLYGLYCEYL-10 PENTAYDXYSTEAATE 12G - Night 1 PLYGLYCEYL-10 PENTAYDXYSTEAATE 12 - Paste Masks (mud packs) 1 PLYGLYCEYL-10 PENTALEATE 03G - ther Eye Makeup Preparatios 1 PLYGLYCEYL-10 PENTALEATE 05B - air Spray (aerosol fixatives) 1 PLYGLYCEYL-10 PENTALEATE 05G - Toics, Dressigs, ad ther air Groo 1 PLYGLYCEYL-10 PENTALEATE 07E - Lipstick 1 PLYGLYCEYL-10 PENTALEATE 12G - Night 1 PLYGLYCEYL-10 PENTASTEAATE 03D - Eye Lotio 1 PLYGLYCEYL-10 PENTASTEAATE 05A - air Coditioer 1 PLYGLYCEYL-10 PENTASTEAATE 07C - Foudatios 1 PLYGLYCEYL-10 PENTASTEAATE 12A - Cleasig 1 PLYGLYCEYL-10 PENTASTEAATE 12C - Face ad Neck (exc shave) 3 PLYGLYCEYL-10 PENTASTEAATE 12F - Moisturizig 4 PLYGLYCEYL-10 PENTASTEAATE 12G - Night 2 PLYGLYCEYL-10 STEAATE 03C - Eye Shadow 2 PLYGLYCEYL-10 STEAATE 03D - Eye Lotio 1 PLYGLYCEYL-10 STEAATE 03G - ther Eye Makeup Preparatios 8 PLYGLYCEYL-10 STEAATE 05G - Toics, Dressigs, ad ther air Groo 1 PLYGLYCEYL-10 STEAATE 07C - Foudatios 2 PLYGLYCEYL-10 STEAATE 07F - Makeup Bases 1 PLYGLYCEYL-10 STEAATE 12A - Cleasig 5 PLYGLYCEYL-10 STEAATE 12C - Face ad Neck (exc shave) 15 PLYGLYCEYL-10 STEAATE 12D - Body ad ad (exc shave) 14 PLYGLYCEYL-10 STEAATE 12E - Foot Powders ad Sprays 1 PLYGLYCEYL-10 STEAATE 12F - Moisturizig 21 PLYGLYCEYL-10 STEAATE 12G - Night 2 PLYGLYCEYL-10 STEAATE 12 - Paste Masks (mud packs) 2 PLYGLYCEYL-10 STEAATE 12I - Ski Fresheers 1 PLYGLYCEYL-10 STEAATE 12J - ther Ski Care Preps 10 PLYGLYCEYL-10 STEAATE 13A - Suta Gels, Creams, ad Liquids 3 PLYGLYCEYL-10 TISTEAATE 03D - Eye Lotio 1 PLYGLYCEYL-2 CAPATE 12D - Body ad ad (exc shave) 4 PLYGLYCEYL-2 CAPATE 12F - Moisturizig 1 PLYGLYCEYL-2 DIISSTEAATE 03C - Eye Shadow 1 PLYGLYCEYL-2 DIISSTEAATE 03D - Eye Lotio 3 PLYGLYCEYL-2 DIISSTEAATE 03F - Mascara 2 PLYGLYCEYL-2 DIISSTEAATE 07A - Blushers (all types) 1 PLYGLYCEYL-2 DIISSTEAATE 07C - Foudatios 1 PLYGLYCEYL-2 DIISSTEAATE 07E - Lipstick 32 PLYGLYCEYL-2 DIISSTEAATE 07F - Makeup Bases 2 PLYGLYCEYL-2 DIISSTEAATE 07G - ouges 7 PLYGLYCEYL-2 DIISSTEAATE 07 - Makeup Fixatives 3

113 Distributed for Commet ly -- Do Not Cite or Quote Polyglyceryl Fatty Acid Esters FDA VCP PLYGLYCEYL-2 DIISSTEAATE 07I - ther Makeup Preparatios 3 PLYGLYCEYL-2 DIISSTEAATE 12A - Cleasig 1 PLYGLYCEYL-2 DIISSTEAATE 12C - Face ad Neck (exc shave) 10 PLYGLYCEYL-2 DIISSTEAATE 12D - Body ad ad (exc shave) 3 PLYGLYCEYL-2 DIISSTEAATE 12F - Moisturizig 5 PLYGLYCEYL-2 DIISSTEAATE 12 - Paste Masks (mud packs) 1 PLYGLYCEYL-2 DIISSTEAATE 13A - Suta Gels, Creams, ad Liquids 1 DIGLYCEYL DIISSTEAATE 07E - Lipstick 1 DIGLYCEYL DIISSTEAATE 07F - Makeup Bases 1 DIGLYCEYL DIISSTEAATE 12C - Face ad Neck (exc shave) 2 DIGLYCEYL DIISSTEAATE 12F - Moisturizig 2 DIGLYCEYL DIISSTEAATE 12J - ther Ski Care Preps 1 PLYGLYCEYL-2 ISPALMITATE 07E - Lipstick 9 PLYGLYCEYL-2 ISSTEAATE 07B - Face Powders 2 PLYGLYCEYL-2 ISSTEAATE 07C - Foudatios 2 PLYGLYCEYL-2 ISSTEAATE 07I - ther Makeup Preparatios 1 PLYGLYCEYL-2 ISSTEAATE 10E - ther Persoal Clealiess Products 1 PLYGLYCEYL-2 ISSTEAATE 12J - ther Ski Care Preps 1 PLYGLYCEYL-2 LAUATE 03D - Eye Lotio 1 PLYGLYCEYL-2 LAUATE 05F - Shampoos (o-colorig) 1 PLYGLYCEYL-2 LAUATE 12A - Cleasig 2 PLYGLYCEYL-2 LAUATE 12C - Face ad Neck (exc shave) 1 PLYGLYCEYL-2 LAUATE 12F - Moisturizig 1 PLYGLYCEYL-2 LAUATE 12G - Night 1 PLYGLYCEYL-2 LAUATE 12I - Ski Fresheers 1 PLYGLYCEYL-2 LAUATE 12J - ther Ski Care Preps 1 PLYGLYCEYL-2 LEATE 07C - Foudatios 1 PLYGLYCEYL-2 LEATE 12F - Moisturizig 2 PLYGLYCEYL-2 SESQUIISSTEAATE 07C - Foudatios 1 PLYGLYCEYL-2 SESQUIISSTEAATE 07E - Lipstick 2 PLYGLYCEYL-2 SESQUIISSTEAATE 07I - ther Makeup Preparatios 1 PLYGLYCEYL-2 SESQUIISSTEAATE 08G - ther Maicurig Preparatios 1 PLYGLYCEYL-2 SESQUIISSTEAATE 12A - Cleasig 2 PLYGLYCEYL-2 SESQUIISSTEAATE 12C - Face ad Neck (exc shave) 2 PLYGLYCEYL-2 SESQUIISSTEAATE 12F - Moisturizig 2 PLYGLYCEYL-2 TETAISSTEAATE 07C - Foudatios 2 PLYGLYCEYL-2 TETAISSTEAATE 07E - Lipstick 25 PLYGLYCEYL-2 TETAISSTEAATE 07I - ther Makeup Preparatios 1 PLYGLYCEYL-2 TIISSTEAATE 03A - Eyebrow Pecil 5 PLYGLYCEYL-2 TIISSTEAATE 03B - Eyelier 3 PLYGLYCEYL-2 TIISSTEAATE 03C - Eye Shadow 10 PLYGLYCEYL-2 TIISSTEAATE 03E - Eye Makeup emover 2 PLYGLYCEYL-2 TIISSTEAATE 07A - Blushers (all types) 6 PLYGLYCEYL-2 TIISSTEAATE 07B - Face Powders 2 PLYGLYCEYL-2 TIISSTEAATE 07C - Foudatios 7 PLYGLYCEYL-2 TIISSTEAATE 07E - Lipstick 88 PLYGLYCEYL-2 TIISSTEAATE 07F - Makeup Bases 2 PLYGLYCEYL-2 TIISSTEAATE 07G - ouges 8

114 Distributed for Commet ly -- Do Not Cite or Quote Polyglyceryl Fatty Acid Esters FDA VCP PLYGLYCEYL-2 TIISSTEAATE 07I - ther Makeup Preparatios 13 PLYGLYCEYL-2 TIISSTEAATE 10E - ther Persoal Clealiess Products 1 PLYGLYCEYL-2 TIISSTEAATE 12C - Face ad Neck (exc shave) 1 PLYGLYCEYL-2 TIISSTEAATE 12D - Body ad ad (exc shave) 2 PLYGLYCEYL-2 TIISSTEAATE 12F - Moisturizig 4 PLYGLYCEYL-2 TIISSTEAATE 12G - Night 2 PLYGLYCEYL-2 TIISSTEAATE 12J - ther Ski Care Preps 2 PLYGLYCEYL-2 TIISSTEAATE 13A - Suta Gels, Creams, ad Liquids 2 PLYGLYCEYL-3 BEESWAX 03C - Eye Shadow 1 PLYGLYCEYL-3 BEESWAX 03D - Eye Lotio 5 PLYGLYCEYL-3 BEESWAX 03F - Mascara 3 PLYGLYCEYL-3 BEESWAX 03G - ther Eye Makeup Preparatios 1 PLYGLYCEYL-3 BEESWAX 04E - ther Fragrace Preparatio 1 PLYGLYCEYL-3 BEESWAX 07C - Foudatios 11 PLYGLYCEYL-3 BEESWAX 07E - Lipstick 8 PLYGLYCEYL-3 BEESWAX 07F - Makeup Bases 1 PLYGLYCEYL-3 BEESWAX 07I - ther Makeup Preparatios 2 PLYGLYCEYL-3 BEESWAX 11E - Shavig Cream 3 PLYGLYCEYL-3 BEESWAX 12C - Face ad Neck (exc shave) 5 PLYGLYCEYL-3 BEESWAX 12D - Body ad ad (exc shave) 2 PLYGLYCEYL-3 BEESWAX 12F - Moisturizig 9 PLYGLYCEYL-3 BEESWAX 12G - Night 3 PLYGLYCEYL-3 BEESWAX 12 - Paste Masks (mud packs) 5 PLYGLYCEYL-3 BEESWAX 12J - ther Ski Care Preps 3 PLYGLYCEYL-3 CAPATE 10A - Bath Soaps ad Detergets 1 PLYGLYCEYL-3 CAPATE 10B - Deodorats (uderarm) 11 PLYGLYCEYL-3 CAPYLATE 10A - Bath Soaps ad Detergets 2 PLYGLYCEYL-3 CAPYLATE 10B - Deodorats (uderarm) 6 PLYGLYCEYL-3 CAPYLATE 12A - Cleasig 1 PLYGLYCEYL-3 CAPYLATE 12C - Face ad Neck (exc shave) 1 PLYGLYCEYL-3 CAPYLATE 12J - ther Ski Care Preps 1 PLYGLYCEYL-3 DICITATE/STEAATE 05G - Toics, Dressigs, ad ther air Groo 3 PLYGLYCEYL-3 DICITATE/STEAATE 12F - Moisturizig 1 PLYGLYCEYL-3 DIISSTEAATE 02A - Bath ils, Tablets, ad Salts 1 PLYGLYCEYL-3 DIISSTEAATE 03B - Eyelier 8 PLYGLYCEYL-3 DIISSTEAATE 03C - Eye Shadow 18 PLYGLYCEYL-3 DIISSTEAATE 03D - Eye Lotio 2 PLYGLYCEYL-3 DIISSTEAATE 03F - Mascara 7 PLYGLYCEYL-3 DIISSTEAATE 03G - ther Eye Makeup Preparatios 6 PLYGLYCEYL-3 DIISSTEAATE 07A - Blushers (all types) 5 PLYGLYCEYL-3 DIISSTEAATE 07B - Face Powders 4 PLYGLYCEYL-3 DIISSTEAATE 07C - Foudatios 20 PLYGLYCEYL-3 DIISSTEAATE 07E - Lipstick 206 PLYGLYCEYL-3 DIISSTEAATE 07F - Makeup Bases 2 PLYGLYCEYL-3 DIISSTEAATE 07 - Makeup Fixatives 1 PLYGLYCEYL-3 DIISSTEAATE 07I - ther Makeup Preparatios 9 PLYGLYCEYL-3 DIISSTEAATE 10A - Bath Soaps ad Detergets 1 PLYGLYCEYL-3 DIISSTEAATE 10E - ther Persoal Clealiess Products 2 PLYGLYCEYL-3 DIISSTEAATE 11E - Shavig Cream 1 PLYGLYCEYL-3 DIISSTEAATE 12A - Cleasig 1 PLYGLYCEYL-3 DIISSTEAATE 12C - Face ad Neck (exc shave) 13 PLYGLYCEYL-3 DIISSTEAATE 12D - Body ad ad (exc shave) 11 PLYGLYCEYL-3 DIISSTEAATE 12F - Moisturizig 23 PLYGLYCEYL-3 DIISSTEAATE 12G - Night 4

115 Distributed for Commet ly -- Do Not Cite or Quote Polyglyceryl Fatty Acid Esters FDA VCP PLYGLYCEYL-3 DIISSTEAATE 12J - ther Ski Care Preps 4 PLYGLYCEYL-3 DIISSTEAATE 13A - Suta Gels, Creams, ad Liquids 5 PLYGLYCEYL-3 DIISSTEAATE 13B - Idoor Taig Preparatios 1 PLYGLYCEYL-3 DIISSTEAATE 13C - ther Suta Preparatios 1 PLYGLYCEYL-3 DISTEAATE 05A - air Coditioer 1 PLYGLYCEYL-3 DISTEAATE 05F - Shampoos (o-colorig) 2 PLYGLYCEYL-3 DISTEAATE 05G - Toics, Dressigs, ad ther air Groo 1 PLYGLYCEYL-3 DISTEAATE 12F - Moisturizig 4 PLYGLYCEYL-3 ISSTEAATE 03D - Eye Lotio 1 PLYGLYCEYL-3 ISSTEAATE 07F - Makeup Bases 1 PLYGLYCEYL-3 ISSTEAATE 12A - Cleasig 2 PLYGLYCEYL-3 ISSTEAATE 12C - Face ad Neck (exc shave) 2 PLYGLYCEYL-3 ISSTEAATE 12D - Body ad ad (exc shave) 2 PLYGLYCEYL-3 ISSTEAATE 12F - Moisturizig 3 PLYGLYCEYL-3 LAUATE 05F - Shampoos (o-colorig) 8 PLYGLYCEYL-3 LAUATE 05G - Toics, Dressigs, ad ther air Groo 1 PLYGLYCEYL-3 LAUATE 10A - Bath Soaps ad Detergets 106 PLYGLYCEYL-3 LAUATE 12A - Cleasig 1 PLYGLYCEYL-3 LAUATE 12D - Body ad ad (exc shave) 1 PLYGLYCEYL-3 LAUATE 12 - Paste Masks (mud packs) 1 PLYGLYCEYL-3 LEATE 03G - ther Eye Makeup Preparatios 2 PLYGLYCEYL-3 LEATE 12A - Cleasig 1 PLYGLYCEYL-3 LEATE 12C - Face ad Neck (exc shave) 1 PLYGLYCEYL-3 LEATE 12D - Body ad ad (exc shave) 1 PLYGLYCEYL-3 LEATE 12F - Moisturizig 3 PLYGLYCEYL-3 LEATE 12 - Paste Masks (mud packs) 2 PLYGLYCEYL-3 LEATE 12I - Ski Fresheers 1 PLYGLYCEYL-3 LEATE 12J - ther Ski Care Preps 1 PLYGLYCEYL-3 LEATE 13A - Suta Gels, Creams, ad Liquids 2 PLYGLYCEYL-3 ICINLEATE 03F - Mascara 2 PLYGLYCEYL-3 ICINLEATE 03G - ther Eye Makeup Preparatios 3 PLYGLYCEYL-3 ICINLEATE 07C - Foudatios 3 PLYGLYCEYL-3 ICINLEATE 07I - ther Makeup Preparatios 1 PLYGLYCEYL-3 ICINLEATE 12D - Body ad ad (exc shave) 2 PLYGLYCEYL-3 ICINLEATE 12F - Moisturizig 50 PLYGLYCEYL-3 ICINLEATE 13B - Idoor Taig Preparatios 1 PLYGLYCEYL-3 STEAATE 07A - Blushers (all types) 1 PLYGLYCEYL-3 STEAATE 07E - Lipstick 1 PLYGLYCEYL-3 STEAATE 12A - Cleasig 3 PLYGLYCEYL-3 STEAATE 12C - Face ad Neck (exc shave) 4 PLYGLYCEYL-3 STEAATE 12D - Body ad ad (exc shave) 4 PLYGLYCEYL-3 STEAATE 12G - Night 2 PLYGLYCEYL-4 CAPATE 02A - Bath ils, Tablets, ad Salts 1 PLYGLYCEYL-4 CAPATE 03E - Eye Makeup emover 2 PLYGLYCEYL-4 CAPATE 05G - Toics, Dressigs, ad ther air Groo 1 PLYGLYCEYL-4 CAPATE 07I - ther Makeup Preparatios 1 PLYGLYCEYL-4 CAPATE 10A - Bath Soaps ad Detergets 3 PLYGLYCEYL-4 CAPATE 10B - Deodorats (uderarm) 1 PLYGLYCEYL-4 CAPATE 12A - Cleasig 4 PLYGLYCEYL-4 CAPATE 12C - Face ad Neck (exc shave) 2

116 Distributed for Commet ly -- Do Not Cite or Quote Polyglyceryl Fatty Acid Esters FDA VCP PLYGLYCEYL-4 ISSTEAATE 01B - Baby Lotios, ils, Powders, ad Cream 1 PLYGLYCEYL-4 ISSTEAATE 03A - Eyebrow Pecil 1 PLYGLYCEYL-4 ISSTEAATE 03B - Eyelier 3 PLYGLYCEYL-4 ISSTEAATE 03C - Eye Shadow 23 PLYGLYCEYL-4 ISSTEAATE 03D - Eye Lotio 2 PLYGLYCEYL-4 ISSTEAATE 03F - Mascara 4 PLYGLYCEYL-4 ISSTEAATE 03G - ther Eye Makeup Preparatios 17 PLYGLYCEYL-4 ISSTEAATE 05G - Toics, Dressigs, ad ther air Groo 2 PLYGLYCEYL-4 ISSTEAATE 07A - Blushers (all types) 3 PLYGLYCEYL-4 ISSTEAATE 07B - Face Powders 3 PLYGLYCEYL-4 ISSTEAATE 07C - Foudatios 86 PLYGLYCEYL-4 ISSTEAATE 07D - Leg ad Body Paits 3 PLYGLYCEYL-4 ISSTEAATE 07E - Lipstick 41 PLYGLYCEYL-4 ISSTEAATE 07F - Makeup Bases 13 PLYGLYCEYL-4 ISSTEAATE 07G - ouges 1 PLYGLYCEYL-4 ISSTEAATE 07 - Makeup Fixatives 2 PLYGLYCEYL-4 ISSTEAATE 07I - ther Makeup Preparatios 28 PLYGLYCEYL-4 ISSTEAATE 08G - ther Maicurig Preparatios 1 PLYGLYCEYL-4 ISSTEAATE 12C - Face ad Neck (exc shave) 7 PLYGLYCEYL-4 ISSTEAATE 12D - Body ad ad (exc shave) 1 PLYGLYCEYL-4 ISSTEAATE 12F - Moisturizig 12 PLYGLYCEYL-4 ISSTEAATE 12G - Night 1 PLYGLYCEYL-4 ISSTEAATE 12 - Paste Masks (mud packs) 1 PLYGLYCEYL-4 ISSTEAATE 12J - ther Ski Care Preps 11 PLYGLYCEYL-4 ISSTEAATE 13B - Idoor Taig Preparatios 3 PLYGLYCEYL-4 LAUATE 03D - Eye Lotio 1 PLYGLYCEYL-4 LAUATE 07C - Foudatios 2 PLYGLYCEYL-4 LAUATE 07I - ther Makeup Preparatios 2 PLYGLYCEYL-4 LAUATE 12A - Cleasig 1 PLYGLYCEYL-4 LAUATE 12F - Moisturizig 3 PLYGLYCEYL-4 LAUATE 13B - Idoor Taig Preparatios 1 PLYGLYCEYL-4 LEATE 03D - Eye Lotio 2 PLYGLYCEYL-4 LEATE 07C - Foudatios 1 PLYGLYCEYL-4 LEATE 07D - Leg ad Body Paits 1 PLYGLYCEYL-4 LEATE 12F - Moisturizig 3 PLYGLYCEYL-5 DILEATE 10E - ther Persoal Clealiess Products 1 PLYGLYCEYL-5 ISSTEAATE 03G - ther Eye Makeup Preparatios 1 PLYGLYCEYL-5 ISSTEAATE 12D - Body ad ad (exc shave) 1 PLYGLYCEYL-5 LAUATE 02B - Bubble Baths 1 PLYGLYCEYL-5 LAUATE 10A - Bath Soaps ad Detergets 1 PLYGLYCEYL-5 LEATE 10E - ther Persoal Clealiess Products 1 PLYGLYCEYL-5 LEATE 12A - Cleasig 1 PLYGLYCEYL-5 LEATE 12F - Moisturizig 2 PLYGLYCEYL-5 LEATE 12I - Ski Fresheers 4 PLYGLYCEYL-5 LEATE 12J - ther Ski Care Preps 2 PLYGLYCEYL-5 TILEATE 12C - Face ad Neck (exc shave) 5 PLYGLYCEYL-5 TILEATE 12F - Moisturizig 1

117 Distributed for Commet ly -- Do Not Cite or Quote Polyglyceryl Fatty Acid Esters FDA VCP PLYGLYCEYL-6 DILEATE 05A - air Coditioer 6 PLYGLYCEYL-6 DILEATE 07E - Lipstick 2 PLYGLYCEYL-6 DILEATE 07I - ther Makeup Preparatios 7 PLYGLYCEYL-6 DILEATE 12A - Cleasig 1 PLYGLYCEYL-6 DILEATE 12C - Face ad Neck (exc shave) 1 PLYGLYCEYL-6 DILEATE 12D - Body ad ad (exc shave) 6 PLYGLYCEYL-6 DILEATE 12F - Moisturizig 2 PLYGLYCEYL-6 DILEATE 12J - ther Ski Care Preps 2 PLYGLYCEYL-6 DISTEAATE 01B - Baby Lotios, ils, Powders, ad Cream 1 PLYGLYCEYL-6 DISTEAATE 03C - Eye Shadow 1 PLYGLYCEYL-6 DISTEAATE 03D - Eye Lotio 1 PLYGLYCEYL-6 DISTEAATE 03F - Mascara 2 PLYGLYCEYL-6 DISTEAATE 07C - Foudatios 1 PLYGLYCEYL-6 DISTEAATE 07E - Lipstick 1 PLYGLYCEYL-6 DISTEAATE 10E - ther Persoal Clealiess Products 1 PLYGLYCEYL-6 DISTEAATE 12C - Face ad Neck (exc shave) 7 PLYGLYCEYL-6 DISTEAATE 12D - Body ad ad (exc shave) 1 PLYGLYCEYL-6 DISTEAATE 12F - Moisturizig 3 PLYGLYCEYL-6 DISTEAATE 12G - Night 2 PLYGLYCEYL-6 DISTEAATE 13B - Idoor Taig Preparatios 1 PLYGLYCEYL-6 ISSTEAATE 07E - Lipstick 1 PLYGLYCEYL-6 ISSTEAATE 12C - Face ad Neck (exc shave) 7 PLYGLYCEYL-6 ISSTEAATE 12D - Body ad ad (exc shave) 1 PLYGLYCEYL-6 ISSTEAATE 12F - Moisturizig 3 PLYGLYCEYL-6 ISSTEAATE 12J - ther Ski Care Preps 1 PLYGLYCEYL-6 ISSTEAATE 13A - Suta Gels, Creams, ad Liquids 1 PLYGLYCEYL-6 CTASTEAATE 12F - Moisturizig 1 PLYGLYCEYL-6 LEATE 12C - Face ad Neck (exc shave) 1 PLYGLYCEYL-6 ICINLEATE 07E - Lipstick 1 PLYGLYCEYL-8 DECAEUCATE/DECAISSTEAATE/DECAICINLEATE 12C - Face ad Neck (exc shave) 1 TIISSTEAYL PLYGLYCEYL-3 DIME DILINLEATE 03C - Eye Shadow 1 TIISSTEAYL PLYGLYCEYL-3 DIME DILINLEATE 07E - Lipstick 17 TIISSTEAYL PLYGLYCEYL-3 DIME DILINLEATE 07I - ther Makeup Preparatios 1

118 Cocetratio of Use by FDA Product Category Polyglyceryl Esters* Acacia Decurres/Jojoba/ Suflower Seed Wax Polyglyceryl-3 Esters Adasoia Digitata Seed il Polyglyceryl-6 Esters Almod il/polyglyceryl-10 Esters Apricot Kerel il Polyglyceryl-3 Esters Apricot Kerel il Polyglyceryl-4 Esters Apricot Kerel il Polyglyceryl-5 Esters Apricot Kerel il Polyglyceryl-6 Esters Apricot Kerel il Polyglyceryl-10 Esters Arga il Polyglyceryl-6 Esters Astrocaryum Vulgare il Polyglyceryl-6 Esters Avocado il Polyglyceryl-6 Esters Babassu il Polyglyceryl-4 Esters Babassu il Polyglyceryl-6 Esters Bertholletia Excelsa Seed il Polyglyceryl-6 Esters Borage Seed il Polyglyceryl-4 Esters Borage Seed il Polyglyceryl-6 Esters Cadelilla/Jojoba/ice Bra Polyglyceryl-3 Esters Carapa Guaiaesis il Polyglyceryl-6 Esters Castor il Polyglyceryl-6 Esters Cocoa Butter Polyglyceryl-6 Esters Cocout il Polyglyceryl-6 Esters Coffee Seed il Polyglyceryl-6 Esters azelut Seed il Polyglyceryl-6 Esters Liseed il Polyglyceryl-4 Esters Macadamia Seed il Polyglyceryl-6 Esters Mauritia Flexuosa Seed il Polyglyceryl-6 Esters live il Polyglyceryl-3 Esters live il Polyglyceryl-4 Esters live il Polyglyceryl-6 Esters Palm Kerel il Polyglyceryl-4 Esters Palm il Polyglyceryl-3 Esters Palm il Polyglyceryl-4 Esters Palm il Polyglyceryl-5 Esters Palm il Polyglyceryl-6 Esters Pariari Curatellifolia il Polyglyceryl-6 Esters Pius Sibirica Seed il Polyglyceryl-6 Esters Polyglyceryl-6 Adasoia Digitata Seedate Polyglyceryl-4 Almodate/Shea Butterate Polyglyceryl-6 Apricot Kerelate Polyglyceryl-10 Apricot Kerelate Polyglyceryl-6 Arga Kerelate Polyglyceryl-3 Beeswax Polyglyceryl-3 Beheate Polyglyceryl-6 Beheate Polyglyceryl-10 Beheate/Eicosadioate Polyglyceryl-8 C12-20 Acid Ester Polyglyceryl-2 Caprate Polyglyceryl-3 Caprate Polyglyceryl-4 Caprate Polyglyceryl-5 Caprate Distributed for Commet ly -- Do Not Cite or Quote Polyglyceryl-6 Caprate Polyglyceryl-10 Caprate Polyglyceryl-2 Caprylate Polyglyceryl-3 Caprylate Polyglyceryl-4 Caprylate Polyglyceryl-6 Caprylate Polyglyceryl-10 Caprylate Polyglyceryl-4 Caprylate/Caprate Polyglyceryl-6 Caprylate/Caprate Polyglyceryl-10 Caprylate/Caprate Polyglyceryl-6 Citrullus Laatus Seedate Polyglyceryl-3 Cocoate Polyglyceryl-4 Cocoate Polyglyceryl-10 Cocoate Polyglyceryl-2 Isopalmitate/Sebacate Polyglyceryl-2 Isostearate Polyglyceryl-3 Isostearate Polyglyceryl-4 Isostearate Polyglyceryl-5 Isostearate Polyglyceryl-6 Isostearate Polyglyceryl-10 Isostearate Polyglyceryl-10 Eicosaedioate/Tetradecaedioate Polyglyceryl-4 azelutseedate Polyglyceryl-2 Isopalmitate Polyglyceryl-4 Isostearate/Laurate Polyglyceryl-2 Laurate Polyglyceryl-3 Laurate Polyglyceryl-4 Laurate Polyglyceryl-5 Laurate Polyglyceryl-6 Laurate Polyglyceryl-10 Laurate Polyglyceryl-10 Lioleate Polyglyceryl-2 Myristate Polyglyceryl-3 Myristate Polyglyceryl-5 Myristate Polyglyceryl-6 Myristate Polyglyceryl-10 Myristate Polyglyceryl-2 leate Polyglyceryl-3 leate Polyglyceryl-4 leate Polyglyceryl-5 leate Polyglyceryl-6 leate Polyglyceryl-8 leate Polyglyceryl-10 leate Polyglyceryl-10 Palmate Polyglyceryl-2 Palmitate Polyglyceryl-3 Palmitate Polyglyceryl-6 Palmitate Polyglyceryl-10 Palmitate Polyglyceryl-6 Palmitate/Succiate Polyglyceryl-4 Puicate Page 1 of 10

119 Distributed for Commet ly -- Do Not Cite or Quote Polyglyceryl-3 ice Braate Polyglyceryl-3 icioleate Polyglyceryl-5 icioleate Polyglyceryl-6 icioleate Polyglyceryl-6 Schiziophyto autaeii Kerelate Polyglyceryl-6 Sclerocarya Birrea Seedate Polyglyceryl-3 Soyate/Shea Butterate Polyglyceryl-2 Stearate Polyglyceryl-3 Stearate Polyglyceryl-4 Stearate Polyglyceryl-5 Stearate Polyglyceryl-6 Stearate Polyglyceryl-8 Stearate Polyglyceryl-10 Stearate Polyglyceryl-3 Stearate SE Polyglyceryl-4 Sweet Almodate Polyglyceryl-6 Trichilia Emetica Seedate Polyglyceryl-6 Udecyleate Polyglyceryl-10 Udecyleate Polyglyceryl-6 Ximeia Americaa Seedate Pumpki Seed il Polyglyceryl-4 Esters ice Bra il Polyglyceryl-3 Esters osa ubigiosa Seed il Polyglyceryl-6 Esters Safflower Seed il Polyglyceryl-6 Esters Schiziophyto autaeii Kerel il Polyglyceryl-6 Esters Sclerocarya Birrea Seed il Polyglyceryl-6 Esters Sclerocarya Birrea Seed il Polyglyceryl-10 Esters Sesame il Polyglyceryl-6 Esters Shea Butter Polyglyceryl-3 Esters Shea Butter Polyglyceryl-6 Esters Soybea il Polyglyceryl-6 Esters Suflower Seed il Polyglyceryl-3 Esters Suflower Seed il Polyglyceryl-4 Esters Suflower Seed il Polyglyceryl-5 Esters Suflower Seed il Polyglyceryl-6 Esters Suflower Seed il Polyglyceryl-10 Esters Sweet Almod il Polyglyceryl-4 Esters Sweet Almod il Polyglyceryl-6 Esters Theobroma Gradiflorum Seed Butter Polyglyceryl-6 Esters Trichilia Emetica Seed il Polyglyceryl-6 Esters Watermelo Seed il Polyglyceryl-6 Esters Watermelo Seed il Polyglyceryl-10 Esters Ximeia Americaa Seed il Polyglyceryl-6 Esters Macadamia Seed il Polyglyceryl-6 Esters Beheate Polyglyceryl-8 Decabeheate/Caprate Polyglyceryl-8 Decaerucate/Decaisostearate/ Decaricioleate Polyglyceryl-10 Decaethylhexaoate Polyglyceryl-10 Decahydroxystearate Polyglyceryl-10 Decaisostearate Polyglyceryl-10 Decalioleate Polyglyceryl-10 Decamacadamiate Polyglyceryl-10 Decaoleate Polyglyceryl-10 Decastearate Polyglyceryl-3 Dicaprate Polyglyceryl-6 Dicaprate Polyglyceryl-5 Dicaprylate Polyglyceryl-3 Dicitrate/Stearate Polyglyceryl-3 Dicocoate Polyglyceryl-10 Dicocoate Polyglyceryl-10 Didecaoate Polyglyceryl-3 Di-ydroxystearate Polyglyceryl-2 Diisostearate Polyglyceryl-3 Diisostearate Polyglyceryl-6 Diisostearate Polyglyceryl-10 Diisostearate Polyglyceryl-15 Diisostearate Polyglyceryl-4 Dilaurate Polyglyceryl-5 Dilaurate Polyglyceryl-10 Dilaurate Polyglyceryl-10 Dimyristate Polyglyceryl-2 Dioleate Polyglyceryl-3 Dioleate Polyglyceryl-5 Dioleate Polyglyceryl-6 Dioleate Polyglyceryl-10 Dioleate Polyglyceryl-6 Dipalmitate Polyglyceryl-10 Dipalmitate Polyglyceryl-2 Distearate Polyglyceryl-3 Distearate Polyglyceryl-4 Distearate Polyglyceryl-6 Distearate Polyglyceryl-10 Distearate Polyglyceryl-20 Docosabeheate/Isostearate Polyglyceryl-20 Docosabeheate/Laurate Polyglyceryl-20 Docosabeheate/leate Polyglyceryl-10 Dodecabeheate Polyglyceryl-10 Dodecacaprate Polyglyceryl-10 Dodecacaprylate Polyglyceryl-10 Dodeca-Caprylate/Caprate Polyglyceryl-10 epta(beheate/stearate) Polyglyceryl-6 eptacaprylate Polyglyceryl-20 eptacaprylate Polyglyceryl-20 eptadecabeheate/laurate Polyglyceryl-10 eptahydroxystearate Polyglyceryl-10 eptaoleate Polyglyceryl-10 eptastearate Polyglyceryl-20 exacaprylate Polyglyceryl-10 exaerucate Polyglyceryl-10 exaisostearate Polyglyceryl-6 exaoleate Polyglyceryl-10 exaoleate Page 2 of 10

120 Distributed for Commet ly -- Do Not Cite or Quote Polyglyceryl-5 exastearate Polyglyceryl-6 exastearate Polyglyceryl-10 Moo/Dioleate Polyglyceryl-10 Noaerucate Polyglyceryl-10 Noaisostearate Polyglyceryl-6 ctacaprylate Polyglyceryl-20 ctadecabeheate/laurate Polyglyceryl-20 ctaisooaoate Polyglyceryl-6 ctastearate Polyglyceryl-6 Petacaprylate Polyglyceryl-10 Petacaprylate Polyglyceryl-3 Petacaprylate/Caprate Polyglyceryl-10 Petahydroxystearate Polyglyceryl-10 Petaisostearate Polyglyceryl-10 Petalaurate Polyglyceryl-10 Petalioleate Polyglyceryl-5 Petamyristate Polyglyceryl-4 Petaoleate Polyglyceryl-6 Petaoleate Polyglyceryl-10 Petaoleate Polyglyceryl-3 Petaolivate Polyglyceryl-4 Petapalmitate/Stearate Polyglyceryl-3 Petaricioleate Polyglyceryl-6 Petaricioleate Polyglyceryl-10 Petaricioleate Polyglyceryl-4 Petastearate Polyglyceryl-6 Petastearate Polyglyceryl-10 Petastearate Polyglyceryl-2 Sesquicaprylate Polyglyceryl-6 Sesquicaprylate Polyglyceryl-2 Sesquiisostearate Polyglyceryl-6 Sesquiisostearate Polyglyceryl-2 Sesquioleate Polyglyceryl-2 Sesquistearate Polyglyceryl-6 Sesquistearate Polyglyceryl-10 Sesquistearate Polyglyceryl-6 Tetrabeheate Polyglyceryl-2 Tetrabeheate/Macadamiate/Sebacate Polyglyceryl-6 Tetracaprylate Polyglyceryl-10 Tetradecaedioate Polyglyceryl-2 Tetraisostearate Polyglyceryl-10 Tetralaurate Polyglyceryl-2 Tetraoleate Polyglyceryl-6 Tetraoleate Polyglyceryl-10 Tetraoleate Polyglyceryl-2 Tetrastearate Polyglyceryl-5 Tribeheate Polyglyceryl-6 Tricaprylate Polyglyceryl-10 Tricocoate Polyglyceryl-10 Tridecaoate Polyglyceryl-10 Trierucate Polyglyceryl-2 Triisostearate Polyglyceryl-3 Triisostearate Polyglyceryl-5 Triisostearate Polyglyceryl-10 Triisostearate Polyglyceryl-10 Trilaurate Polyglyceryl-5 Trimyristate Polyglyceryl-5 Trioleate Polyglyceryl-10 Trioleate Polyglyceryl-3 Triolivate Polyglyceryl-4 Tristearate Polyglyceryl-5 Tristearate Polyglyceryl-6 Tristearate Polyglyceryl-10 Tristearate Triisostearoyl Polyglyceryl-3 Dimer Dilioleate Page 3 of 10

121 Distributed for Commet ly -- Do Not Cite or Quote Igrediet Product Category Maximum Cocetratio of Use Acacia Decurres/Jojoba/Suflower Seed Wax Polyglyceryl-3 Esters Face ad eck products ot spray, ot powder 2% Babassu il Polyglyceryl-6 Esters Ski cleasig (cold creams, cleasig 2.3% lotios, liquids ad pads) Cadelilla/Jojoba/ice Bra Polyglyceryl-6 Esters Baby lotios, oils ad creams ot powder 1.5% Cadelilla/Jojoba/ice Bra Polyglyceryl-6 Esters Deodorats aerosol 0.5% Cadelilla/Jojoba/ice Bra Polyglyceryl-6 Esters Face ad eck products ot spray 1% Cadelilla/Jojoba/ice Bra Polyglyceryl-6 Esters Night products ot spray 2% Polyglyceryl-3 Beeswax Eye shadow % Polyglyceryl-3 Beeswax Eye lotio 2.2-3% Polyglyceryl-3 Beeswax Face powder 3.4% Polyglyceryl-3 Beeswax Foudatio % Polyglyceryl-3 Beeswax Lipstick % Polyglyceryl-3 Beeswax Makeup fixatives 2.5% Polyglyceryl-3 Beeswax Shavig cream 0.75% Polyglyceryl-3 Beeswax Ski cleasig (cold creams, cleasig 2.5% lotios, liquids ad pads) Polyglyceryl-3 Beeswax Face ad eck products ot spray 4% Polyglyceryl-3 Beeswax Suta products ot spray 0.5% Polyglyceryl-10 Beheate/Eicosadioate Lipstick 2% Polyglyceryl-10 Beheate/Eicosadioate Ski cleasig (cold creams, cleasig 5% lotios, liquids ad pads) Polyglyceryl-4 Caprate Shampoos (ocolorig) 1.1% Polyglyceryl-4 Caprate Toics, dressigs ad other hair groomig 0.5% aids Polyglyceryl-4 Caprate Bath soaps ad detergets 1-1.5% Polyglyceryl-4 Caprate Deodorats ot spray 1.5% Polyglyceryl-4 Caprate Ski cleasig (cold creams cleasig 0.9-1% lotios, liquids ad pads) Polyglyceryl-4 Caprate Face ad eck products ot spray 0.72% Polyglyceryl-3 Caprylate Cologes ad toilet water 0.05% Polyglyceryl-3 Caprylate Deodorats ot spray aerosol 0.5-1% 0.6% Polyglyceryl-3 Caprylate ther persoal clealiess products 0.6% Polyglyceryl-3 Caprylate Body ad had products ot spray 0.05% Polyglyceryl-6 Caprylate/Caprate Shampoos (ocolorig) 0.75% Polyglyceryl-2 Isostearate Lipstick % Polyglyceryl-2 Isostearate Ski cleasig (cold creams, cleasig 1% lotios, liquids ad pads) Polyglyceryl-2 Isostearate Body ad had products ot spray 2.1% Polyglyceryl-2 Isostearate Moisturizig products ot spray % Page 4 of 10

122 Polyglyceryl-4 Isostearate Baby lotios oils ad creams ot powder 1% Polyglyceryl-4 Isostearate Eyebrow pecil 13.2% Polyglyceryl-4 Isostearate Eyelier % Polyglyceryl-4 Isostearate Eye shadow % Polyglyceryl-4 Isostearate Eye lotio % Polyglyceryl-4 Isostearate Mascara 2.8% Polyglyceryl-4 Isostearate ther eye makeup preparatios % Polyglyceryl-4 Isostearate Toics, dressigs ad other hair groomig 2.1% aids Polyglyceryl-4 Isostearate Face powders 0.17% Polyglyceryl-4 Isostearate Foudatios % Polyglyceryl-4 Isostearate Leg ad body pait 0.26% Polyglyceryl-4 Isostearate Lipstick % Polyglyceryl-4 Isostearate Makeup bases 0.067% Polyglyceryl-4 Isostearate Makeup fixatives 1.4-3% Polyglyceryl-4 Isostearate ther makeup preparatios % Polyglyceryl-4 Isostearate ther oral hygiee products 0.16% Polyglyceryl-4 Isostearate Ski cleasig (cold creams, cleasig 1.7% lotios, liquids ad pads) Polyglyceryl-4 Isostearate Face ad eck products ot spray % Polyglyceryl-4 Isostearate Body ad had products ot spray % Polyglyceryl-4 Isostearate Moisturizig products ot spray 2% Polyglyceryl-4 Isostearate Night products ot spray 1-1.3% Polyglyceryl-4 Isostearate Suta products ot spray aerosol % 0.26% Polyglyceryl-4 Isostearate Idoor taig preparatios 1.1% Polyglyceryl-10 Isostearate Face ad eck products pump spray 0.6% Polyglyceryl-10 Isostearate Moisturizig products ot spray 0.6% Polyglyceryl-2 Laurate air coditioers 4.6% Polyglyceryl-2 Laurate Toics, dressigs ad other hair groomig 2% aids Polyglyceryl-3 Laurate Eye shadow 6% Polyglyceryl-3 Laurate air coditioer 2% Polyglyceryl-3 Laurate Shampoos (ocolorig) % Polyglyceryl-3 Laurate Depilatories 2% Polyglyceryl-4 Laurate Ski cleasig (cold creams, cleasig 0.47% lotios, liquids ad pads) Polyglyceryl-5 Laurate Ski cleasig (cold creams, cleasig 0.6% Polyglyceryl-5 Laurate lotios, liquids ad pads) Face ad eck products ot spray 0.6% Polyglyceryl-5 Laurate ther ski care preparatios 0.6% Polyglyceryl-10 Laurate Baby shampoo 1% Polyglyceryl-10 Laurate ther baby products 1% Polyglyceryl-10 Laurate Bubble bath 2% Polyglyceryl-10 Laurate ther bath preparatios 0.69% Polyglyceryl-10 Laurate Perfumes 0.5% Polyglyceryl-10 Laurate Shampoos (ocolorig) 0.4-5% Polyglyceryl-10 Laurate Distributed for Commet ly -- Do Not Cite or Quote Toics, dressigs ad other hair groomig aids Page 5 of %

123 Distributed for Commet ly -- Do Not Cite or Quote Polyglyceryl-10 Laurate ther hair preparatios (ocolorig) 5% Polyglyceryl-10 Laurate Foudatios % Polyglyceryl-10 Laurate Ski cleasig (cold creams, cleasig 0.2-1% lotios, liquids ad pads) Polyglyceryl-10 Myristate Deodorats ot spray aerosol % 0.1% Polyglyceryl-10 Myristate Shavig cream % Polyglyceryl-10 Myristate Ski cleasig (cold creams, cleasig % lotios, liquids ad pads) Polyglyceryl-10 Myristate Body ad had products ot spray 0.8% Polyglyceryl-10 Myristate Moisturizig products ot spray % Polyglyceryl-2 leate Eye lotios 0.27% Polyglyceryl-2 leate Eye makeup removers 2.4% Polyglyceryl-2 leate ther eye makeup preparatios 1.6% Polyglyceryl-2 leate Foudatios 1-1.6% Polyglyceryl-2 leate Lipstick 2.4% Polyglyceryl-2 leate Face ad eck products ot spray 0.09% Polyglyceryl-2 leate Moisturizig products ot spray 0.09% Polyglyceryl-2 leate Night products ot spray 0.09% Polyglyceryl-3 leate Eye lotio 1.5% Polyglyceryl-3 leate Toics, dressigs ad other hair groomig aids ot spray 1.2% Polyglyceryl-4 leate Leg ad body paits 1.8% Polyglyceryl-4 leate Suta products aerosol 1.8% Polyglycery-5 leate Face ad eck products ot spray 0.35% Polyglyceryl-10 leate Bath oils, tablets ad salts 2% Polyglyceryl-10 leate Eye lotio 0.63% Polyglyceryl-10 leate air coditioers % Polyglyceryl-10 leate air spray pump spray 1% Polyglyceryl-10 leate Shampoos (ocolorig) % Polyglyceryl-10 leate Ski cleasig (cold creams, cleasig % lotios, liquids ad pads) Polyglyceryl-10 leate Face ad eck products ot spray % Polyglyceryl-10 leate Body ad had products ot spray 3% Polyglyceryl-10 leate Moisturizig products ot spray 0.21% Polyglyceryl-10 leate Night products ot spray 0.21% Polyglyceryl-10 leate ther ski care preparatios 3% Polyglyceryl-3 icioleate Foudatios 2% Polyglyceryl-3 icioleate Body ad had products ot spray 0.25% Polyglyceryl-2 Stearate Eye lotio 1% Polyglyceryl-2 Stearate Eye makeup remover 0.2% Polyglyceryl-2 Stearate Lipstick 0.2% Page 6 of 10

124 Distributed for Commet ly -- Do Not Cite or Quote Polyglyceryl-2 Stearate Face ad eck products ot spray 2.2% Polyglyceryl-2 Stearate Moisturizig products ot spray 0.16% Polyglyceryl-3 Stearate Blushers 0.54% Polyglyceryl-3 Stearate Lipstick 0.5% Polyglyceryl-3 Stearate Ski cleasig (cold creams, cleasig 0.61% lotios, liquids ad pads) Polyglyceryl-5 Stearate Body ad had products ot spray 1% Polyglyceryl-10 Stearate Eyelier 1.8% Polyglyceryl-10 Stearate Eye shadow 0.41% Polyglyceryl-10 Stearate Toics, dressigs ad other hair groomig 0.25% aids Polyglyceryl-10 Stearate Foudatios 0.36% Polyglyceryl-10 Stearate Ski cleasig (cold creams, cleasig 1% lotios, liquids ad pads) Polyglyceryl-10 Stearate Face ad eck products ot spray 0.2-2% Polyglyceryl-10 Stearate Body ad had products ot spray 0.13% Polyglyceryl-10 Stearate Moisturizig products ot spray % Polyglyceryl-10 Stearate Night products ot spray 1.2% Macadamia Seed il Polyglyceryl-6 Eye shadow 2% Esters Beheate Macadamia Seed il Polyglyceryl-6 Mascara 3% Esters Beheate Macadamia Seed il Polyglyceryl-6 Foudatio 2% Esters Beheate Macadamia Seed il Polyglyceryl-6 Lipstick 25% Esters Beheate Polyglyceryl-8 Decabeheate/Caprate Lipstick 9% Polyglyceryl-10 Decaisostearate Eye shadow 2.7% Polyglyceryl-10 Decaoleate Foudatio 5% Polyglyceryl-10 Decaoleate Lipstick 5% Polyglyceryl-10 Decaoleate ther oral hygiee products 0.01% Polyglyceryl-10 Decaoleate Face ad eck products ot spray or powder 1% Polyglyceryl-3 Dicitrate/Stearate Toics, dressigs ad other hair groomig 2.2% aids Polyglyceryl-3 Dicitrate/Stearate Face ad eck products ot spray 3-4% Polyglyceryl-3 Dicitrate/Stearate Body ad had products ot spray 2% Polyglyceryl-2 Diisostearate Eye shadow 2-2.3% Polyglyceryl-2 Diisostearate Eye lotio 1.5-4% Polyglyceryl-2 Diisostearate Mascara 4% Polyglyceryl-2 Diisostearate Perfume 0.5% Polyglyceryl-2 Diisostearate Powders (dustig ad talcum) 0.1% Polyglyceryl-2 Diisostearate air coditioers 0.88% Polyglyceryl-2 Diisostearate air spray pump spray 0.25% Polyglyceryl-2 Diisostearate Toics, dressigs ad other hair groomig 15% aids Polyglyceryl-2 Diisostearate Foudatio 2% Polyglyceryl-2 Diisostearate Lipstick % Page 7 of 10

125 Polyglyceryl-2 Diisostearate Makeup bases 2% Polyglyceryl-2 Diisostearate Deodorat ot spray 0.1% Polyglyceryl-2 Diisostearate Aftershave lotio 1% Polyglyceryl-2 Diisostearate Ski cleasig (cold creams, cleasig 5% lotios, liquids ad pads) Polyglyceryl-2 Diisostearate Face ad eck products ot spray % Polyglyceryl-2 Diisostearate Body ad had products ot spray 0.5-2% Polyglyceryl-2 Diisostearate Moisturizig products ot spray % Polyglyceryl-2 Diisostearate ther ski care preparatios 1.2% Polyglyceryl-3 Diisostearate Baby lotios, oils ad creams ot powder 2% Polyglyceryl-3 Diisostearate ther bath preparatios 0.5% Polyglyceryl-3 Diisostearate Eyebrow pecil % Polyglyceryl-3 Diisostearate Eye lier 3.8-8% Polyglyceryl-3 Diisostearate Eye shadow % Polyglyceryl-3 Diisostearate Eye lotio % Polyglyceryl-3 Diisostearate Mascara 1.5% Polyglyceryl-3 Diisostearate ther eye makeup preparatios 1% Polyglyceryl-3 Diisostearate air coditioers % Polyglyceryl-3 Diisostearate air spray aerosol % % pump spray Polyglyceryl-3 Diisostearate Shampoos (ocolorig) 0.003% Polyglyceryl-3 Diisostearate Toics, dressigs ad other hair groomig aids aerosol % Polyglyceryl-3 Diisostearate Blushers % Polyglyceryl-3 Diisostearate Face powder 0.25% Polyglyceryl-3 Diisostearate Foudatios % Polyglyceryl-3 Diisostearate Lipstick % Polyglyceryl-3 Diisostearate ouge 3% Polyglyceryl-3 Diisostearate Makeup fixatives 4.6% Polyglyceryl-3 Diisostearate ther oral hygiee products 29.7% Polyglyceryl-3 Diisostearate Deodorat ot spray % Polyglyceryl-3 Diisostearate ther persoal clealiess products 0.003% Polyglyceryl-3 Diisostearate ther shavig preparatios 0.5% Polyglyceryl-3 Diisostearate Ski cleasig (cold creams, cleasig 4.8% lotios liquids ad pads) Polyglyceryl-3 Diisostearate Face ad eck products ot spray % Polyglyceryl-3 Diisostearate Body ad had products ot spray spray % 0.5% Polyglyceryl-3 Diisostearate Moisturizig products ot spray 1-2% Polyglyceryl-3 Diisostearate Night products ot spray 0.5-1% Polyglyceryl-3 Diisostearate Paste masks ad mud packs 0.006% Polyglyceryl-3 Diisostearate Distributed for Commet ly -- Do Not Cite or Quote Suta products ot spray 10% Page 8 of 10

126 Distributed for Commet ly -- Do Not Cite or Quote Polyglyceryl-10 Diisostearate Toics, dressigs ad other hair groomig 2% aids Polyglyceryl-10 Diisostearate Ski cleasig (cold creams, cleasig % lotios, liquids ad pads) Polyglyceryl-10 Diisostearate Face ad eck products ot spray 0.8% Polyglyceryl-6 Dioleate air coditioers 1.8% Polyglyceryl-6 Dioleate Body ad had products ot spray 2.4% Polyglyceryl-10 Dioleate ther makeup preparatios 3.9% Polyglyceryl-10 Dipalmitate ther bath preparatios 2% Polyglyceryl-10 Dipalmitate ther persoal clealiess products 2% Polyglyceryl-10 Dipalmitate Face ad eck products ot spray 10% Polyglycery-3 Distearate Mascara % Polyglycery-3 Distearate Toics, dressigs ad other hair groomig 1% aids Polyglycery-3 Distearate Body ad had creams ot spray spray 0.29% 3% Polyglycery-3 Distearate Suta products ot spray 1.3% Polyglyceryl-6 Distearate Mascara 4% Polyglyceryl-6 Distearate Foudatio 4% Polyglyceryl-6 Distearate Lipstick 22.4% Polyglyceryl-6 Distearate ouge 10.5% Polyglyceryl-6 Distearate Cuticle softeer 5% Polyglyceryl-10 eptahydroxystearate Foudatio 1% Polyglyceryl-10 eptahydroxystearate Lipstick 2% Polyglyceryl-10 Noaisostearate Ski cleasig (cold creams, cleasig 0.5% lotios, liquids ad pads) Polyglyceryl-10 Petaisostearate Lipstick 4.8% Polyglyceryl-10 Petaisostearate Body ad had products ot spray 2% Polyglyceryl-10 Petaoleate Toics, dressigs ad other hair groomig 1% aids Polyglyceryl-10 Petaoleate Lipstick 2.6% Polyglyceryl-6 Petastearate Eyelier 5% Polyglyceryl-3 Petaricioleate Eyelier 0.15% Polyglyceryl-10 Petastearate Foudatio % Polyglyceryl-10 Petastearate Lipstick % Polyglyceryl-10 Petastearate ther makeup preparatios % Polyglyceryl-10 Petastearate Ski cleasig (cold creams, cleasig % lotios, liquids ad pads) Polyglyceryl-10 Petastearate Face ad eck products 2-2.2% ot spray Polyglyceryl-10 Petastearate Body ad had products ot spray 1% Polyglyceryl-10 Petastearate Moisturizig products ot spray 1.3% Polyglyceryl-10 Petastearate Night products ot spray 0.38% Polyglyceryl-10 Petastearate Suta products ot spray 1.3% Polyglyceryl-2 Sesquiisostearate Eye lotio 2.1% Polyglyceryl-2 Sesquiisostearate Foudatio 3% Polyglyceryl-2 Sesquiisostearate Lipstick 7.6% Page 9 of 10

127 Distributed for Commet ly -- Do Not Cite or Quote Polyglyceryl-2 Sesquiisostearate Ski cleasig (cold creams, cleasig 1.1% lotios, liquids ad pads) Polyglyceryl-2 Sesquiisostearate Face ad eck products ot spray 4.4% Polyglyceryl-2 Sesquistearate Ski cleasig (cold creams, cleasig 0.9% lotios, liquids ad pads) Polyglyceryl-2 Tetraisostearate Face powder 0.96% Polyglyceryl-2 Tetraisostearate Foudatio % Polyglyceryl-2 Tetraisostearate Lipstick 7% Polyglyceryl-6 Tricaprylate ther makeup preparatios 3.6% Polyglyceryl-2 Triisostearate Eyebrow pecil 2.2-3% Polyglyceryl-2 Triisostearate Eyelier % Polyglyceryl-2 Triisostearate Eye shadow 2.6-3% Polyglyceryl-2 Triisostearate air tits 3% Polyglyceryl-2 Triisostearate Blushers 17% Polyglyceryl-2 Triisostearate Face powder % Polyglyceryl-2 Triisostearate Foudatio 0.2-4% Polyglyceryl-2 Triisostearate Lipstick % Polyglyceryl-2 Triisostearate ther makeup preparatios 3.6% Polyglyceryl-2 Triisostearate Ski cleasig (cold creams, cleasig 1-4% lotios, liquids ad pads) Polyglyceryl-2 Triisostearate Face ad eck products ot spray 5% Polyglyceryl-2 Triisostearate Body ad had products ot spray 1% Polyglyceryl-2 Triisostearate Suta products ot spray 3% Polyglyceryl-5 Triisostearate Foudatio 1% Polyglyceryl-5 Triisostearate Lipstick 5% Polyglyceryl-5 Trioleate air coditioers 2.8% Triisostearoyl Polyglyceryl-3 Dimer Eyelier 1% Dilioleate Triisostearoyl Polyglyceryl-3 Dimer Eye shadow 1.2% Dilioleate Triisostearoyl Polyglyceryl-3 Dimer Mascara 1.2% Dilioleate Triisostearoyl Polyglyceryl-3 Dimer Dilioleate Lipstick % *Igrediets icluded i the title of the table but ot foud i the table were icluded i the survey, but o uses were reported. Iformatio collected i 2014 Table prepared December 24, 2014 Page 10 of 10

128 Distributed for Commet ly -- Do Not Cite or Quote Cocetratio of Use by FDA Product Category Polyglyceryl Additios* Diisostearoyl Polyglyceryl-3 Dimer Dilioleate Polyglyceryl-2 Cocoate/Shea Butterate Shea Butter Polyglyceryl-4 Esters Igrediet Product Category Maximum Cocetratio of Use Diisostearoyl Polyglyceryl-3 Foudatios 4% Dimer Dilioleate Diisostearoyl Polyglyceryl-3 Dimer Dilioleate Body ad had products Not spray 2% *Igrediets icluded i the title of the table but ot foud i the table were icluded i a cocetratio of use survey, but o uses were reported. Iformatio collected i 2015 Table prepared April 10, 2015

129 Distributed for Commet ly -- Do Not Cite or Quote Memoradum T: FM: Lillia Gill, D.P.A. Director - CSMETIC INGEDIENT EVIEW (CI) Beth A. Lage, Ph.D. Idustry Liaiso to the CI Expert Pael DATE: July 6, 2015 SUBJECT: Cocetratio of Use by FDA Product Category: Caprylic/Capric Glycerides Polyglyceryl-10 Esters ad Pumpki Seed il Polyglyceryl-4 Esters Succiate Caprylic/Capric Glycerides Polyglyceryl-10 Esters ad Pumpki Seed il Polyglyceryl-4 Esters Succiate were icluded i a cocetratio of use survey. No uses were reported.

130 Distributed for Commet ly -- Do Not Cite or Quote Cocetratio of Use by FDA Product Category Polyglyceryl 10 ydroxystearate/stearate/eicosadioate Product Category Maximum Cocetratio of Use Lipstick % Ski cleasig (cold creams, cleasig lotios, liquids ad pads) 1.8% Iformatio collected i 2015 Table prepared ctober 8, 2015

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242 Polyglycerol esterificatio for highly effective ad aturalbased igrediets. Distributed for Commet ly -- Do Not Cite or Quote

243 Distributed for Commet ly -- Do Not Cite or Quote Polyglycerol esters i cosmetics Surface-active polyglycerol ester-based igrediets meet both criteria of the cosmetic market: Performace ad eco-efficiecy: Very mild, o-irritatig, o sesitizig Moisturizig ad ski smoothig igh biodegradability ad low aquatic toxicity Use of reewable raw materials PEG-free Broad rage of LB values possible Also used i food idustry ighly versatile Cosumer Specialties Page 2

244 Distributed for Commet ly -- Do Not Cite or Quote Polyglycerol esterificatio oe key techology for sustaiable processig at Evoik Starch / Cor Glucose Near Critical Gas Extractio APG s Ethoxylates Cocout Palm apeseed Fatty acids Glyceri Ezymatic Esterificatio Glyceri Codesatio Esters Ether Sulfates Polyglycerol Esters Soy Fatty Acid Methyl Ester Fatty Alcohols Alkyl Ethers Isomeric Alcohols Ceramides Yeast Bacteria oot igh Quality Fermetatio Sphigolipids Polymers Crude Extract Super-Critical Extractio Molecular Distillatio Glucas Polyamio Acids Turmeric il Cosumer Specialties Page 3

245 Distributed for Commet ly -- Do Not Cite or Quote The route to atural derived polyglycerol esters i cosmetics Cocout il Castor il - 2 cat. Glyceri codesatio ad apeseed il Palm il Fatty acids ad I additio: variatio of degree of PG polymerisatio: Polyglycerol ester esterificatio % additioal modificatios possible By variatio of codesatio degree, polyglycerol esters ca be tailored to specific applicatios DP Cosumer Specialties Page 4

246 Distributed for Commet ly -- Do Not Cite or Quote Iovatio with polyglycerol esters over the last decade W/ emulsifier for lotios with a light ski feel Polyglyceryl-4 Diisostearate/ Polyhydroxystearate/ Sebacate Naoemulsios for wipes by simple dilutio with water based o Polyglyceryl-4 Laurate Cold processable, costefficiet /W emulsifier Sorbita Laurate; Polyglyceryl-4 Laurate; Dilauryl Citrate 3 C +C C C 2-3 Versatile, cost-efficiet /W emulsifier for creams ad lotios Solubilizers for essetial & perfume oils Solubilizers for lipophilic oils obust /W emulsifier for sprays ad lotios Polyglyceryl-3 Dicitrate/Stearate Polyglyceryl-6 Caprylate; Polyglyceryl-4 Caprate; Proplylee Glycol Polyglyceryl-6 Caprylate; Polyglyceryl-4 Caprate; Polyglyceryl-4 Cocoate, Polygylceryl-6 icioleate Polyglyceryl-6 Stearate; Polyglyceryl-6 Beheate Cosumer Specialties Page 5

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