Supplemental Digital Content 1. Incidence of early nausea: Cumulative incidence 0-6h postoperatively

Transcription

1 Supplemental Digital Content. Incidence of early nausea: Cumulative incidence 0-h postoperatively Piper 0 Purhonen 0 Turan %.%.% 3.% 3.% 4.0% 5.2% 4.% 4.3% M-H, Fixed, 5% CI 0.5 [0.34, 0.] 0.53 [0.25,.3] 0. [0.30,.4] 0.3 [0.5,.].5 [0.3, 3.2]. [0., 4.0].0 [0.54, 2.0] 0. [0.2,.].2 [0.5,.4] M-H, Fixed, 5% CI (5% CI) [0.,.0] events Heterogeneity: Chi² =.3, df = (P = 0.3); I² = 35% Test for overall effect: Z = 0. (P = 0.3)

2 Supplemental Digital Content 2. Incidence of early vomiting: Cumulative incidence 0-h postoperatively Piper 0 Purhonen 0 Turan High FIO2 Normal FI O2 Risk Ratio Risk Ratio % 3.%.0%.2% 5.%.4%.5%.0% 5.5% M-H, Random, 5% CI 0.4 [0.,.0] 0.2 [0.0, 4.3] 3.00 [0.32, 2.].4 [0.2,.5] 0.33 [0.04, 3.] 0.2 [0.03, 2.] 3. [0.4, 32.4] 0.3 [0.02, 0.5] 0.2 [0.2,.] M-H, Random, 5% CI (5% CI) 0 events 4 Heterogeneity: Tau² = 0.30; Chi² = 4.0, df = (P = 0.0); I² = 45% Test for overall effect: Z =.24 (P = 0.22) 0. [0.3,.25]

3 Supplemental Digital Content 3. Incidence of early PONV (any nausea and/or vomiting): Cumulative incidence 0-h postoperatively Bhatnagar 05 Piper 0 Purhonen 0 Thibon Turan % 3.4%.% 3.5% 4.% 4.2% 5.2% 4.% 5.3% 3.% M-H, Fixed, 5% CI 0.33 [0.0,.4] 0.5 [0.33, 0.4] 0.53 [0.25,.3] 0.5 [0.,.]. [0.54, 2.].0 [0.2, 3.52] 0. [0.,.] 0.0 [0.24,.4].42 [0., 2.].2 [0.5,.4] M-H, Fixed, 5% CI (5% CI) [0.0,.0] events 24 Heterogeneity: Chi² = 4.05, df = (P = 0.); I² = 3% Test for overall effect: Z = 0. (P = 0.3)

4 Supplemental Digital Content 4. Incidence of late nausea: Cumulative incidence 0-24h postoperatively Bhatnagar 05 Piper 0 Purhonen 0 Turan % 0.%.5%.4%.% 5.% 3.%.2%.0% M-H, Fixed, 5% CI 0.33 [0.04, 2.4] 0.3 [0., 0.2] 0.5 [0.35, 0.] 0. [0.3,.45].0 [0.53, 2.] 0. [0.,.] 0. [0.,.] 0.2 [0.4,.0] 0.5 [0.53,.3] M-H, Fixed, 5% CI (5% CI) 0 0. [0., 0.3] events 52 5 Heterogeneity: Chi² =., df = (P = 0.3); I² = % Test for overall effect: Z = 2.0 (P = 0.005)

5 Supplemental Digital Content 5. Incidence of late vomiting: Cumulative incidence 0-24h postoperatively Piper 0 Purhonen 0 Turan % 3.%.4% 4.5%.%.%.5% 22.% M-H, Random, 5% CI 0.4 [0.30, 0.0] 0.30 [0.0,.43] 0.2 [0.45,.].00 [0.2, 3.].02 [0.5, 2.05].02 [0.0,.4] 0.4 [0.2,.4].30 [0.,.] M-H, Random, 5% CI (5% CI) 0 events 5 5 Heterogeneity: Tau² = 0.0; Chi² = 5.0, df = (P = 0.04); I² = 54% Test for overall effect: Z = 0.2 (P = 0.3) 0. [0.3,.]

6 Supplemental Digital Content. Incidence of late PONV (any nausea and/or vomiting): Cumulative incidence 0-24h postoperatively Bhatnagar 05 Piper 0 Purhonen 0 Turan % 5.%.4% 30.% 5.% 0.0%.3% 4.3% 2.% M-H, Fixed, 5% CI 0. [0.35, 2.0].4 [0., 2.] 0.5 [0.34, 0.2].0 [0.0,.25].0 [0.5,.] 0. [0.4,.24] 0.3 [0.5,.4] 0.2 [0.4,.4].2 [0.,.] M-H, Fixed, 5% CI (5% CI) [0.2,.] events Heterogeneity: Chi² = 3.35, df = (P = 0.0); I² = 40% Test for overall effect: Z = 0.0 (P = 0.55)

7 Supplemental Digital Content. Incidence of early nausea: Cumulative incidence 0-h postoperatively. Inhalational anesthetics, without anti-emetic prophylaxis Purhonen % 0.%.5% 4.% 4.%.3% 5.% M-H, Fixed, 5% CI 0.5 [0.34, 0.] 0.53 [0.25,.3] 0. [0.30,.4] 0.3 [0.5,.]. [0., 4.0].0 [0.54, 2.0] 0. [0.2,.] M-H, Fixed, 5% CI (5% CI) [0.,.02] events 3 Heterogeneity: Chi² =.55, df = (P = 0.4); I² = 3% Test for overall effect: Z =.5 (P = 0.0) Favors high FIO2 Favors low FIO2

8 Supplemental Digital Content. Incidence of early vomiting: Cumulative incidence 0-h postoperatively. Inhalational anesthetics, without anti-emetic prophylaxis Purhonen % 5.4%.% 32.4%.3%.5% 0.2% M-H, Random, 5% CI 0.4 [0.,.0] 0.2 [0.0, 4.3] 3.00 [0.32, 2.].4 [0.2,.5] 0.2 [0.03, 2.] 3. [0.4, 32.4] 0.3 [0.02, 0.5] M-H, Random, 5% CI (5% CI) 2 events Heterogeneity: Tau² = 0.45; Chi² = 3., df = (P = 0.04); I² = 54% Test for overall effect: Z = 0. (P = 0.3) 0. [0.33,.54] Favors high FIO2 Favors low FIO2

9 Supplemental Digital Content. Incidence of early PONV (any nausea and/or vomiting): Cumulative incidence 0-h postoperatively. Inhalational anesthetics, without anti-emetic prophylaxis Bhatnagar 05 Purhonen %.%.% 3.0%.3% 4.0%.% M-H, Random, 5% CI 0.33 [0.0,.4] 0.5 [0.33, 0.4] 0.53 [0.25,.3] 0.5 [0.,.].0 [0.2, 3.52] 0. [0.,.] 0.0 [0.24,.4] M-H, Random, 5% CI (5% CI) 42 4 events 3 5 Heterogeneity: Tau² = 0.0; Chi² = 0., df = (P = 0.0); I² = 45% Test for overall effect: Z =.40 (P = 0.) 0.0 [0.5,.0]

10 Supplemental Digital Content 0. Incidence of late nausea: Cumulative incidence 0-24h postoperatively. Inhalational anesthetics, without anti-emetic prophylaxis Bhatnagar 05 Purhonen % 4.% 2.%.2%.%.2%.% M-H, Fixed, 5% CI 0.33 [0.04, 2.4] 0.3 [0., 0.2] 0.5 [0.35, 0.] 0. [0.3,.45] 0. [0.,.] 0. [0.,.] 0.2 [0.4,.0] M-H, Fixed, 5% CI (5% CI) [0.2, 0.0] events 0 4 Heterogeneity: Chi² =.05, df = (P = 0.); I² = 34% Test for overall effect: Z = 3.4 (P = 0.002)

11 Supplemental Digital Content. Incidence of late vomiting: Cumulative incidence 0-24h postoperatively. Inhalational anesthetics, without anti-emetic prophylaxis Purhonen %.2%.%.5%.3%.% M-H, Fixed, 5% CI 0.4 [0.30, 0.0] 0.30 [0.0,.43] 0.2 [0.45,.].02 [0.5, 2.05].02 [0.0,.4] 0.4 [0.2,.4] M-H, Fixed, 5% CI (5% CI) [0.5, 0.2] events 5 Heterogeneity: Chi² =.23, df = 5 (P = 0.4); I² = 3% Test for overall effect: Z = 2.5 (P = 0.0)

12 Supplemental Digital Content. Incidence of late PONV (any nausea and/or vomiting): Cumulative incidence 0-24h postoperatively. Inhalational anesthetics, without anti-emetic prophylaxis Bhatnagar 05 Purhonen %.% 5.% 42.5% 3.%.4% 5.% M-H, Fixed, 5% CI 0. [0.35, 2.0].4 [0., 2.] 0.5 [0.34, 0.2].0 [0.0,.25] 0. [0.4,.24] 0.3 [0.5,.4] 0.2 [0.4,.4] M-H, Fixed, 5% CI (5% CI) [0.5,.0] events 23 Heterogeneity: Chi² = 0.5, df = (P = 0.0); I² = 43% Test for overall effect: Z = 0. (P = 0.)

13 Supplemental Digital Content. List of references. Goll V, Akca O, Greif R, Freitag H, Arkilic CF, Scheck T, Zoeggeler A, Kurz A, Krieger G, Lenhardt R, Sessler DI: Ondansetron is no more effective than supplemental intraoperative oxygen for prevention of postoperative nausea and vomiting. Anesth Analg 0; 2: 2-. Greif R, Laciny S, Rapf B, Hickle RS, Sessler DI: Supplemental oxygen reduces the incidence of postoperative nausea and vomiting. Anesthesiology ; : McKeen DM, Arellano R, O'Connell C: Supplemental oxygen does not prevent postoperative nausea and vomiting after gynecological laparoscopy. Can J Anaesth 0; 5: 5-. Simurina T, Mraovic B, Mikulandra S, Sonicki Z, Sulen N, Dukic B, Gan TJ: Effects of high intraoperative inspired oxygen on postoperative nausea and vomiting in gynecologic laparoscopic surgery. J Clin Anesth 0; 22: Thibon P, Borgey F, Boutreux S, Hanouz JL, Le Coutour X, Parienti JJ: Effect of perioperative oxygen supplementation on 30-day surgical site infection rate in abdominal, gynecologic, and breast surgery: the ISO2 randomized controlled trial. Anesthesiology ; : 4-5. Bhatnagar S, Mishra S, Gupta M, Singhal AK, Mandal AS: Effects of different concentrations of intraoperative supplemental oxygen on postoperative nausea and vomiting (PONV) in patients under going modified radical mastectomy The Internet Journal of Anesthesiology 05; :. Joris JL, Poth NJ, Djamadar AM, Sessler DI, Hamoir EE, Defechereux TR, Meurisse MR, Lamy ML: Supplemental oxygen does not reduce postoperative nausea and vomiting after thyroidectomy. Br J Anaesth 03; : 5-5. Piper SN, Rohm KD, Boldt J, Faust KL, Maleck WH, Kranke P, Suttner SW: Inspired oxygen fraction of 0. compared with 0.4 does not further reduce postoperative nausea and vomiting in dolasetron-treated patients undergoing laparoscopic cholecystectomy. Br J Anaesth 0; : Purhonen S, Niskanen M, Wustefeld M, Hirvonen E, Hynynen M: Supplemental 0% oxygen does not attenuate post-operative nausea and vomiting after breast surgery. Acta Anaesthesiol Scand 0; : 2-3. Purhonen S, Turunen M, Ruohoaho UM, Niskanen M, Hynynen M: Supplemental oxygen does not reduce the incidence of postoperative nausea and vomiting after ambulatory gynecologic laparoscopy. Anesth Analg 03; : -. Turan A, Apfel CC, Kumpch M, Danzeisen O, Eberhart LH, Forst H, Heringhaus C, Isselhorst C, Trenkler S, Trick M, Vedder I, Kerger H: Does the efficacy of supplemental oxygen for the prevention of postoperative nausea and vomiting depend on the measured outcome, observational period or site of surgery? Anaesthesia 0; : 2-33