Post-Infectious Irritable Bowel Syndrome. John K. Marshall MD Division of Gastroenterology McMaster University
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1 Post-Infectious Irritable Bowel Syndrome John K. Marshall MD Division of Gastroenterology McMaster University
2 Pathogenesis of IBS Enck P. Nat Rev Dis Primers 2016;2:16014
3 Post-Infectious Irritable Bowel Syndrome Stewart GT. Post-dysenteric colitis. BMJ 1950;1:405-9 Chaudhary NA, Truelove SC. The irritable colon syndrome. Q J Med 1962;31: Hunt RH, O Brien M, Milton-Thompson GJ Stress and the enteron. J Royal Nav Med Service 1974;69:49-51
4 Post-Infectious Irritable Bowel Syndrome Altered bowel habit and abdominal discomfort that persist after acute enteric infection despite clearance of the inciting pathogen and recovery from the acute illness?
5 Walkerton, Ontario Agricultural community Population ~ km NW of Toronto Groundwater supply: 3 drilled wells with chlorination units
6
7 Heavy Rainfall Contaminated Manure Well Contamination
8 Walkerton: May 2000 Outcome: Reported cases of acute GE 1346 Affected Walkerton residents 799 Field epidemiology estimate of acute GE 2321 Affected Walkerton residents 1286 Hospitalizations* 65 Documented hemolytic uremic syndrome+ 27 Attributable deaths 6 * 55% age 0 to % age 1 to 4 N BGOS Health Unit Investigative Report
9 Walkerton Health Study Funded by Ontario MOH and CCFC Multidisciplinary team: Nephrology, ID (UWO) GI (McMaster) Mission: study long-term health outcomes and facilitate local access to medical care Longitudinal cohort study Recruitment through local town hall meetings and advertisements In-person annual standardized interviews and assessments Total enrolment: N=4561
10 Incidence of IBS 2 Years After Acute Gastroenteritis in Walkerton Ontario OR 4.8 (95% CI 3.4,6.8); p<0.001 % with Rome I IBS p<0.001 p< % 27.5% 10.1% N=701 N=904 N=464 Study cohort at risk of PI-IBS (N=2069): Permanent Walkerton adult resident No prior IBS, IBD, celiac disease Self-Reported GE: Increased stool frequency in May 2000 (> 3 BM/d for > 3d) Clinically Suspected GE: Positive stool culture OR Healthcare contact for acute illness during outbreak OR Report of acute illness to 2000 public health survey Acute Gastroenteritis During Outbreak Marshall JK. Gastroenterology 2006;131:445-50
11 IBS After Infectious Enteritis: Systematic Review and Meta-Analysis 45 studies (N=21,421) Follow-up 3 months to 10 years Relative risk for IBS if infectious enteritis in last 12 months: 4.2 (95% CI ) Pooled PI-IBS prevalence 10.1% (95% CI ) at 12 months 14.5% (95% CI ) > 12 months Risk factors for PI-IBS: Female: OR 2.2 ( ) Antbiotics: OR 1.7 ( ) Anxiety: OR 2.0 ( ) Depression: OR 1.5 ( ) Somatization: OR 4.1 ( ) Neuroticism: OR 3.3 ( ) Clinical indicators of enteritis severity Klem F. Gastroenterology 2017 [in press]
12 PI-IBS After Viral Gastroenteritis % RR 6.9 ( ) p= /89 RR=2.3 ( ) p=0.348 RR 1.9 ( ) p= /77 RR 1.2 ( ) p= /86 11/87 3/29 * 1/29 2/26 2/24 Vomiting predicts post viral IBS Marshall JK. Clin Gastroenterol Hepatol 2007;5:457-60
13 A Risk Score for Post-Infectious Irritable Bowel Syndrome Sensitivity Specificity Area under ROC curve = Derivation Cohort Sensitivity Specificity Area under ROC curve = Validation Cohort Risk Score Ranges from 0 to 90: Low (<42) = 10%, Intermediate (43-68) = 35%, High (>69) = 60% Age under 60 = 6; female =9; duration more than 7 days =7; maximum stool frequency more than 6 =6; bloody stool = 4; abdominal cramps = 32; fever = 5; weight loss over 10 pounds = 8; premorbid anxiety/depression = 1; post infectious anxiety/depression = 10 Thabane M, Marshall JK. Am J Gastroenterol 2009;104:
14 Persistence of PI-IBS Symptoms (among subjects with IBS in 2002/2003) N=210 Prevalence of Rome I IBS N=45 Baseline 2 years 4 years 6 years Marshall JK. Gut 2010;59:605-11
15 Stability of IBS Phenotype IBS-D IBS-C IBS-U Marshall JK. Gut 2010;59:605-11
16 Long-Term Clinical Course of Shigellosis: 10-Year Follow-Up Study Prospective cohort study of 2001 Shigella outbreak in Korea 124 hospital employees infected by Shigella sonnei due to contaminated cafeteria food 105 age- and gender-matched non-infected controls Youn YH. J Neurogastroenterol Motil 2016;22:490-6
17 Luminal and Mucosal Factors in the Pathogenesis of IBS Barbara G. Gastroenterology 2016;150:
18 Increased Intestinal Permeability with IBS in Walkerton Ontario P=0.007 % Lactulose- Mannitol Ratio > N=86 N=132 Marshall JK. Aliment Pharmacol Ther 2004;20:
19 Genetic Associations with PI-IBS Gene ID Gene Category SNP ID Associated Allele Frequency Controls Frequency Cases Odds Ratio (95% CI) p value TLR9 Innate immunity P545P rs A 41% 48% 1.38 ( ) TLR9 Innate immunity -T1237C rs T 82% 87% 0.69 ( ) IL-6 Innate immunity -G174C rs C 39% 44% 1.28 ( ) CDH1 Intestinal epithelial barrier -C160A rs16260 A 26% 31% 1.26 ( ) IL-6 and CDH1 associations stronger when analysis restricted to subjects with confirmed gastroenteritis exposure Villani AC, Marshall JK. Gastroenterology 2010;138:
20 Genetic Variants are Independent PI-IBS Risk Factors Multiple Logistic Regression Controlling for Clinical Predictors Villani AC, Marshall JK. Gastroenterology 2010;138:
21 Prevalence of Dyspepsia at 8 Years Using Rome II Definition (Short-Form Leeds Dyspepsia Questionnaire) OR for dyspepsia at 8 years: Clinically confirmed vs. controls = 2.67 ( ) Self-reported vs. controls = 2.38 ( ) Clinically- Confirmed GE Self- Reported GE Unexposed Controls Ford AC, Marshall JK. Gastroenterology 2010;138:
22 Post-Infectious IBS After Long-Distance Travel Survey of 1190 long-distance travelers, 7 months after journey Traveler s diarrhea (at least moderate) in 43.3% New-onset IBS at 7 months post travel in 7.2% (95% CI ) (10.7% if diarrhea during travel vs. 2.5% if no traveler s diarrhea) Lowe B. Am J Gastroenterol 2016;111:1320-9
23 Conclusions The Walkerton outbreak was an awful human tragedy The contributions of citizens of Walkerton have enhanced understanding of post-infectious IBS New insights: Epidemiology and natural history Adult Adolescent Risk factors and risk profiling IBS phenotype stability Risk of IBD Role of intestinal permeability Genetic risk factors
24 Acknowledgements McGill University & Genome Quebec Innovation Centre Alexandra-Chloe Villani, Genevieve Geneau, Alexandre Belisle Denis Franchimont McMaster University Stephen M. Collins, Marroon Thabane University of Western Ontario Bill Clark, Amit Garg, Jennifer MacNab Ontario Institute for Cancer Research Mathieu Lemire Mayo Clinic Yuri Saito Study Participants
25 THANK YOU
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