SIMPOSIO Il microbiota intestinale e la sua modulazione nelle patologie dell asse intestino cervello. Microbiota e IBS.
|
|
|
- Warren Taylor
- 5 years ago
- Views:
Transcription
1 SIMPOSIO Il microbiota intestinale e la sua modulazione nelle patologie dell asse intestino cervello Microbiota e IBS Cesare Cremon Policlinico S. Orsola Malpighi Azienda Ospedaliero - Universitaria di Bologna ( )
2
3 Microbiota and IBS: what is the link? New diagnosis of IBS after infectious gastroenteritis (Post infectious IBS) Spiller R, Garsed K. Gastroenterology 2009;136: Antibodies anti-flagellin and human β-defensin-2 increased in IBS Cremon C, et al. Expert Rev Mol Diagn 2010;10: Qualitative and quantitative changes in intestinal microbiota composition of IBS Simrén M, Barbara G, et al. Gut 2013;62: Non-absorbable antibiotics and probiotics effective in IBS Pimentel M, et al. N Engl J Med 2011;364:22-32 Moayyedi P, et al. Gut 2010;59:325-32
4 Campylobacter Shigella Salmonella 1.4 episodes/yr Gastrointestinal infection Acute Symptoms Dysbiosis Post-Infectious IBS Recovery Post-Infectious IBS (6-17%) Spiller et al., Gastroenterology 2009;136:
5 Salmonella outbreak in Bologna (October 19, 1994) Tuna sauce contaminated (Salmonella enteritidis D) 36 schools in the Bologna area 19 ottobre subjects infected (acute symptoms) 1684 pupils (93%) children 3-10 yrs 127 teachers or other school employees (7%) adults yrs Positive fecal cultures decreased from 100% to 1.5% at 3 months post-infection Barbara et al., Aliment Pharmacol Ther 2000;14:
6 Early life salmonellosis and IBS in adulthood Salmonella outbreak in Bologna ( ) Prevalence of IBS (%) 44/189 (23.3%) * 75/204 (36.8%) Non-exposed Exposed *P = OR = 1.92 (95% C.I.= ) Cremon C. et al., Gastroenterology 2014;17:69-77
7 Anti-Flagellins in IBS: pathophysiological mechanisms and clinical evidence Commensal microbes A4-Fla2 (%) Fla-X (%) Flagellins NF-Kβ Altered gut permeability IBS (n=112) PI-IBS (n=27) 29 * 26 * Antibodies anti-flagellins Cytokines TLR-5 PMN CD (n=61) UC (n=50) 48 # 52 # 8 10 TLR-5 Activate innate immunity HC (n=43) 7 7 B cells T cells Target of adaptive immunity Dendritic cells Promote adaptative immunity (directly or indirectly) *P<0.01 vs HC P<0.01 vs IBS # P<0.05 vs IBS Adapted from Gewirtz et al., Am J Physiol 2006 Schoepfer et al., Neurogastroenterol Motil 2008;20: Cremon et al., Expert Rev Gastroenterol Hepatol 2008;2:735-40
8 TLR-4 mrna quantification Best cutoff range between IBS and HC: HC IBS UC GUSB GUSB GUSB 1,0 0,9 0,8 0,7 TLR4 TLR4 TLR4 Sensitivity 0,6 0,5 0,4 0,3 0,2 * * * *P=0.005 vs HC **P=0.003 vs IBS 0,1 0,0 0,0 0,1 0,2 0,3 0,4 0,5 0,6 0,7 0,8 0,9 1,0 Specificity Best cutoff range between UC and IBS: ,0 0,9 0,8 0,7 Sensitivity 0,6 0,5 0,4 0,3 0,2 0,1 0,0 0,0 0,1 0,2 0,3 0,4 0,5 0,6 0,7 0,8 0,9 1,0 Specificity Cremon et al., DDW 2013
9 Gut microbiota and factors affecting its distribution Microbiota Microbes that collectively inhabit a given ecosystem (several trillion microbial cells) Simrén M et al., Gut 2013;62:159-76
10 Functional and phylogenetic profiles of human gut microbiome Phylum Class Order Family Genus Species Arumugam M et al., Nature 2011;473:
11 Different composition of fecal microbiota in IBS vs healthy Axis2 (20.3%) 1.5 Multivariate analysis (RDA) HC IBS 62 primary care IBS (Rome II), 46 HC Deep molecular analysis 2-fold Firmicutes/Bacteroidetes ratio Multivariate analysis identifies 2 distinct enterotypes -1.5 C V IBS symptoms correlated with 18 phylogenetic groups (R = ) -1.5 Axis1 (50%) 1.5 Rajilić-Stojanović et al., Gastroenterology 2011;141:
12 Irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota Sequenced S rrna gene V4 region amplicons per subjects High Firmicutes:Bacteroidetes ratio IBS (red) Normal Firmicutes:Bacteroidetes ratio IBS (blu) HAD depression score in normal-like IBS group Jerrery IB et al., Gut 2012,61:
13 Gut microbiota composition and host-microbe cross-talk Jalanka-Tuovinen J et al., Gut 2014;63:
14 Pre-dominant bacteria contributing to dysbiosis in IBS Firmicutes (Bacilli) Proteobacteria Actinobacteria Shigella/Escherichia Ruminococcus gravus Casén C et al., Aliment Pharmacol Ther 2015;42:71-83
15 Intestinal microbiota and IBS severity Tap J et al., Gastroenterology 2017;152:
16
17 Strategies for modifying gut microbiota Fecal microbial transfer Simrén M et al., Gut 2013;62:159-76
18 Major claims of probiotics in IBS Modulate gastrointestinal motility Reduce visceral hypersensitivity Reduce low grade mucosal immune activation Improve epithelial permeability Enhance gut-brain communication Restore intestinal dysbiosis (?) Several of these claims based on convincing experimental evidence from preclinical studies Ohland CL. Et al. Am J Physiol Gastrointest Liver Physiol 2010 ;298:G807-19
19 Bifidobacterium lactis DN improves symptoms and gastrointestinal transit in patients with IBS-C 34 Rome III IBS patients with IBS-C Randomized, controlled, double-blind, parallel group trial 4 weeks of treatment Test product Control product Agrawal A et al., Aliment Pharmacol Ther 2009;29:104-14
20 Bifidobacterium infantis improves IBS symptoms and reduces minimal inflammation 77 Rome II IBS patients (64% women) all bowel habits Pre-Treatment Post-Treatment 200 Composite Likert Score * * * * * * * Treatment Period *P=0.05 IL-10:IL-12 ratio * *P=0.001 B. infantis L. salivarius Placebo Weeks O Mahony et al., Gastroenterology 2005;128:541-51
21 Fermented milk product with probiotic modulates brain activity in healthy women Four-week intake of FMPP (Bifidobacterium animalis subsp Lactis, Streptococcus thermophiles, Lactobacillus bulgaricus, and Lactococcus lactis subsp Lactis) can modulate the responsiveness of an extensive brain network in healthy women Tillisch K et al., Gastroenterology 2013;144:
22 Systematic review: probiotics in the management of gastrointestinal symptoms in clinical practice an evidence-based international guide Symptom Probiotics Agreement % Grade of evidence Overall IBS Bifidobacterium bifidum MIMBb75, B. Longum subsp. infantis 35624, Escherichia coli DSM17252, investigative combinations, marketed combinations 100 High IBS-C B. animalis subsp. lactis DN Low IBS-D B. longum subsp. infantis 35624, marketed combinations 100 Moderate Statement Specific probiotics help relieve overall symptom burden in some patients with IBS However No claims approved by European Food & Health Safety Authority (EFSA) Hungin APS et al,. Aliment Pharmacol Ther 2013; 38:
23 Rifaximin for patients with IBS without constipation % Responders Primary End-point Placebo Rifaximin * *P<0.001 Two identically designed, phase 3, multicentre, double blind, placebo-controlled studies (TARGET 1 and TARGET 2) in 1260 patients with IBS Pimentel et al., N Engl J Med 2011;364:22-32
24 IBS-D Rifaximin Re-Treatment Study (TARGET 3) Lembo A et al., Gastroenterology 2016;151:
25
26 IBS patient s experiences, suffering & life thru artwok
27 Leonardo da Vinci, La Gioconda, , Musèe du Louvre, Paris
28
The role of gut microbiome in IBS
The role of gut microbiome in IBS Chung Owyang, MD H. Marvin Pollard Professor of Internal Medicine Professor of Molecular and Integrative Physiology Chief, Division of Gastroenterology Director, Pollard
Microbiome GI Disorders
Microbiome GI Disorders Prof. Ram Dickman Neurogastroenterology Unit Rabin Medical Center Israel 1 Key Points Our gut microbiota Were to find them? Symbiosis or Why do we need them? Dysbiosis or when things
Formulations and Availability 900 BILLION 5,319 HIGH POTENCY PROBIOTIC PEDIATRIC ADULT GERIATRIC PROVEN BY RESEARCH. HIGH-POTENCY. NO SHORTCUTS.
Formulations and Availability S TU D I E S PE R D I S E A S E 39 LIVER Liver Disease, Cirrhosis, Liver Failure, Hepatic Encephalopathy S TU D I E S PE R AG E G RO U P Visbiome Regular Product Code: 693-0412-01
GUT MICROBIOME WHAT IS IT? WHY IS IT IMPORTANT FOR HUMAN HEALTH?
GUT MICROBIOME WHAT IS IT? WHY IS IT IMPORTANT FOR HUMAN HEALTH? Corrie Whisner, PhD School of Nutrition and Health Promotion Arizona State University Center for Research on Ingredient Safety Annual Meeting
Understanding probiotics and health
Understanding probiotics and health Gemma Laws MSc Student Microbiology and Immunology Department The gut microbiota The name given to the total microbial population living in our intestine Bacteria, fungi,
Unlocking the mysteries of gut comfort
Priority Research Programme Foods for improving gut function and comfort Unlocking the mysteries of gut comfort Nicole Roy, Professor AgResearch and Riddet Institute Host institution Foods for gut function
Modulation of abdominal pain by probiotics. Anna Lyra, PhD DuPont Nutrition & Health
Modulation of abdominal pain by probiotics Anna Lyra, PhD DuPont Nutrition & Health Functional gastrointestinal (GI) wellbeing Up to 70% suffer from functional GI symptoms - ¾ do not seek medical care
The Gut Microbiome: 101 Justin Carlson University of Minnesota
The Gut Microbiome: 101 Justin Carlson University of Minnesota Where are we now? 360 B.C. 2003 Human Gut Microbes Associated With Obesity Ley et al., Nature. 2006. Consumer Driven Science For Better of
Unlocking the mysteries of gut comfort
Priority Research Programme Foods for improving gut function and comfort Unlocking the mysteries of gut comfort Nicole Roy, Professor AgResearch and Riddet Institute Host institution Foods for gut function
Gut Lung Axis Implication of the Gut Microbiota beyond its niche
Gut Lung Axis Implication of the Gut Microbiota beyond its niche Reema Subramanian PhD Candidate (4 th year) Supervisor: Prof. Margaret Ip Department of Microbiology, CUHK Joint Graduate Student Seminar
The role of nutrition in optimum gastrointestinal health
The role of nutrition in optimum gastrointestinal health Kelly A. Tappenden, Ph.D., R.D., FASPEN Kraft Foods Human Nutrition Endowed Professor University Distinguished Teacher-Scholar University of Illinois
Gut Microbiota and IBD. Vahedi. H M.D Associate Professor of Medicine DDRI
Gut Microbiota and IBD Vahedi. H M.D Associate Professor of Medicine DDRI 1393.3.1 2 GUT MICROBIOTA 100 Trillion Microbes - 10 times more than cells in our body Collective weight of about 1kg in human
9/18/2018. The Physiological Roles of the Intestinal Microbiota. Learning Objectives
The Physiological Roles of the Intestinal Microbiota Kelly A. Tappenden, Ph.D., R.D., FASPEN Professor and Head, Kinesiology and Nutrition University Distinguished Teacher-Scholar University of Illinois
Effects of Diet and Genetic Factors on Gut Dysbiosis in IBS
Effects of Diet and Genetic Factors on Gut Dysbiosis in IBS Chung Owyang, MD Professor of Medicine Department of Gastroenterology University of Michigan Li-ping Duan*, MD Professor of Medicine Department
The Microbiome: What the gastroenterologist Needs to Know and What the Future Holds
Baharak Moshiree, MD, MS-CI The Microbiome: What the gastroenterologist Needs to Know and What the Future Holds B A H A R A K M O S H I R EE, M D, M S - CI D I R E C TO R O F M OT I LIT Y A S S O C I ATE
Are microbes the missing piece of the gut comfort puzzle?
Priority Research Programme Foods for improving gut function and comfort Are microbes the missing piece of the gut comfort puzzle? Wayne Young Senior Scientist, AgResearch Host institution Foods for gut
UKLIN1693a, date of preparation: March 2013.
1 This table shows the ICE model. Defining the patient s ideas, concerns, and expectations is an important part of the consultation that can lead to better outcomes. 2 Patients with IBS may have visceral
Fecal microbiota transplantation: The When,the How and the Don t. By Dr Rola Hussein
Fecal microbiota transplantation: The When,the How and the Don t By Dr Rola Hussein Introduction Fecal microbiota transplantation (FMT) involves administration of fecal material containing distal gut microbiota
Consistent and Reproducible Production of a Microbiota-based Drug for Recurrent C. difficile
Consistent and Reproducible Production of a Microbiota-based Drug for Recurrent C. difficile Infection: Application of a Novel Diagnostic for Dysbiosis Courtney Jones, BS Rebiotix Inc. Roseville, MN USA
IBS: overview and assessment of pain outcomes and implications for inclusion criteria
IBS: overview and assessment of pain outcomes and implications for inclusion criteria William D. Chey, MD Professor of Medicine University of Michigan What is the Irritable Bowel Syndrome Symptom based
Spectrum of Diverticular Disease. Outline
Spectrum of Disease ACG Postgraduate Course January 24, 2015 Lisa Strate, MD, MPH Associate Professor of Medicine University of Washington, Seattle, WA Outline Traditional theories and updated perspectives
The impact of the microbiome on brain and cognitive development
The Gut-Brain Axis The impact of the microbiome on brain and cognitive development Diane Stadler, PhD, RD Oregon Health & Sciences University, Portland, Oregon Lao-American Nutrition Institute With acknowledgements
Mind Altering Microbes: Role of Microbiota-Gut-Brain Axis in Stress-Related Disorders
Mind Altering Microbes: Role of Microbiota-Gut-Brain Axis in Stress-Related Disorders John F. Cryan Ph.D. Professor & Chair Department of Anatomy & Neuroscience & Principal Investigator, Alimentary Pharmabiotic
Increasing barrier function with multispecies probiotics
Increasing barrier function with multispecies probiotics Elsbeth Pekelharing, MSc Science Liaison We strive for the most effective microbiome management solutions with our evidence-based & indication-specific
Probiotics and IBS. Science and nature in balance
Probiotics and IBS and nature in balance My background Dr Ashton Harper MBBS, ibsc (Phys/Pharm), MRCS MD from University College London School of Medicine 5 years clinical experience in medical and surgical
Gut microbiota in IBS and its modification by diet: probiotics, prebiotics and low FODMAP diet
Gut microbiota in IBS and its modification by diet: probiotics, prebiotics and low FODMAP diet Kevin Whelan PhD RD FBDA Professor of Dietetics Department of Nutritional Sciences King s College London Nutritional
The Gut Factor. Probiotics, the gut microbiome and human health. Thursday November 10, 2016 l 12:00 pm
The Gut Factor Probiotics, the gut microbiome and human health Thursday November 10, 2016 l 12:00 pm Dr. Elena Comelli is an Assistant Professor and holds the Lawson Family Chair in Microbiome Nutrition
PROBIOTICS NEGATIVE ASPECTS
PROBIOTICS NEGATIVE ASPECTS Dr Ismail Moola Department of Medical Gastroenterology CMJAH University of Witwatersrand Putative Benefits of Probiotics Modulate Immune Intestinal Function Increase secretory
PROBIOTIC RESEARCH REVIEW
Probiotics in the Prevention of Eczema: A Randomised Controlled Trial (Allen at al. 2014) The probiotic formula that is used in GENESTRA BRANDS HMF Baby B and HMF Baby F was found to safely and effectively
Analysis of the effect of probiotics on shaping human gut microbiota
Analysis of the effect of probiotics on shaping human gut microbiota Masahira HATTORI Center for Omics and Bioinformatics, The University of Tokyo http://www.cb.k.u-tokyo.ac.jp/hattorilab
The irritable bowel syndrome (IBS) is a common,
faecal occult blood test in a colorectal cancer screening programme. Br J Cancer 2009;101:1274 1281. 23. Levi Z, Rozen P, Hazazi R, et al. A quantitative immunochemical fecal occult blood test for colorectal
Probiotics : What we Know and Where we are Going Next
Probiotics : What we Know and Where we are Going Next Neerja Hajela, Ph.D. General Manager - Science and Regulatory Affairs Yakult Danone India Pvt. Ltd. Functional Food Market Probiotics an important
Efficacy of synbiotic, probiotic, and prebiotic treatments for irritable bowel syndrome in children: A randomized controlled trial
Efficacy of synbiotic, probiotic, and prebiotic treatments for irritable bowel syndrome in children: A randomized controlled trial BOWEL Ahmet Baştürk, Reha Artan, Aygen Yılmaz Department of Pediatric
Shifts in the Intestinal Microbiota
Shifts in the Intestinal Microbiota Therapeutic Opportunities for Pre- and Probiotics? Kelly A. Tappenden, Ph.D., R.D., FASPEN Kraft Foods Human Nutrition Endowed Professor Editor-in-Chief, Journal of
SYNBIOTIC EFFECTS DO THEY MAKE A DIFFERENCE?
SYNBIOTIC EFFECTS DO THEY MAKE A DIFFERENCE? Gail Cresci, PhD, RD, LD, CNSC Associate Staff Departments of Gastroenterology/Nutrition/Pathobiology Cleveland Clinic Cleveland, OH Objectives Discuss rationale
Manipulating the gut microbiome
Manipulating the gut microbiome William DePaolo, PhD Associate Professor Medicine Director Center for Microbiome Sciences & Therapeutics University of Washington Microbiota The actual bugs that reside
Probiotics in Pediatric Health. AANP Annual Convention
Probiotics in Pediatric Health AANP Annual Convention Don Brown, ND July 12, 2017 Human Microbiome Richness and Metabolic Markers Human gut microbial composition was studied in 292 Danish adults Individuals
Examining the effects of pre and probiotics on gut microbiota during the ageing process
Session: Reviewing key ingredients shaping nutrition for healthy ageing Tuesday 22 nd November 2016 Examining the effects of pre and probiotics on gut microbiota during the ageing process Louise R Wilson
HMP is lead by NIH but is an International Consortium.
Human Microbiome The Human Microbiome Project was one of the spin offs of the Human Genome Project. The HMP project started in 2007 with the overall goal of Characterizing the Human Microbiome and determine
Gut microbiota: importance
Gut microbiota: importance Gut microbiota: importance BACTERIA IN THE GUT SYNTHESIZE SEVERAL HUNDRED GRAMS OF ESSENTIAL AMINO-ACIDS EVERY DAY PROKARYOTES (Bacteria) capability to synthesize essential compounds
Post-Infectious Irritable Bowel Syndrome. John K. Marshall MD Division of Gastroenterology McMaster University
Post-Infectious Irritable Bowel Syndrome John K. Marshall MD Division of Gastroenterology McMaster University Pathogenesis of IBS Enck P. Nat Rev Dis Primers 2016;2:16014 Post-Infectious Irritable Bowel
Microbiota and mental health: gut bacteria influences brain structure and behaviour. Jane A. Foster, PhD
Microbiota and mental health: gut bacteria influences brain structure and behaviour Jane A. Foster, PhD Disclosures Funding sources Industry/Academic Partnerships Gut-brain Axis Bidirectional and continual
Antibiotic Resistance and Probiotics - A Metagenomic Viewpoint
Antibiotic Resistance and Probiotics - A Metagenomic Viewpoint Neerja Hajela, PhD General Manager-Science & Regulatory Affairs Yakult Danone India Pvt. Ltd. Outline of the Presentation Global Epidemiology
השפעת חיידקים פרוביוטיים
השפעת חיידקים פרוביוטיים החיים בחלל )המעי(... על רון שאול יחידת גסטרו ילדים מרכז רפואי רמב"ם Introduction The intestinal microflora primarily in the large bowel consists mostly on benign bacterial species
Bringing Synbiotic Interventions in Cancer to Practice: from bench to bedside The UC Davis Foods for Health Institute
Bringing Synbiotic Interventions in Cancer to Practice: from bench to bedside The UC Davis Foods for Health Institute Jennifer T. Smilowitz, PhD Associate Director, Human Studies Research jensm@ucdavis.edu
More than a gut feeling: How the microbiota improves health
More than a gut feeling: How the microbiota improves health Amanda Ramer-Tait, PhD Harold and Esther Edgerton Assistant Professor of Immunology and Microbiology Department of Food Science, University of
PROBIOTICS: WHO S WHO AND WHAT S WHAT IN THE GUT PROBIOTICS: WHAT ARE THEY, AND HOW DO THEY WORK? Karen Jensen, (Retired ND)
PROBIOTICS: WHO S WHO AND WHAT S WHAT IN THE GUT Karen Jensen, (Retired ND) Today many people are aware of the benefits of maintaining a healthy gut. As a result, probiotic use is becoming ever more popular.
Breastfeeding and the Microbiome
Breastfeeding and the Microbiome JENNY WALTERS MPH, IBCLC Objectives At the conclusion of this session, participants will be able to: Identify ways the microbiota is passed from mother to baby Identify
Dysbiosis & Inflammation
MASTERING THE MICROBIOME: Dysbiosis & Inflammation 2017 Tom Fabian, PhD It is reasonable to propose that the composition of the microbiome and its activities are involved in most, if not all, of the biological
ROME IV CRITERIA FOR IBS
PRACTICAL CONSIDERATIONS IN THE MANAGEMENT OF IBS BRENDA HORWITZ MD PROFESSOR OF CLINICAL MEDICINE LEWIS KATZ SCHOOL OF MEDICINE AND TEMPLE UNIVERSITY HEALTH SCIENCES CENTER OR THINGS I ALWAYS WANTED TO
Slide 1. Slide 2 Learning outcomes. Slide 3. Year 1 MBChB Lecture 15 Introduction to the Gut Microbiota. The importance of microbiota
Slide 1 Year 1 MBChB Lecture 15 Introduction to the Gut Microbiota Professor Barry Campbell Gastroenterology Research Unit Cellular & Molecular Physiology, Institute of Translational Medicine bjcampbl@liv.ac.uk
Clinically proven to quickly relieve symptoms of common gastrointestinal disorders. TERRAGASTRO - Good health starts in the gut
Clinically proven to quickly relieve symptoms of common gastrointestinal disorders GASTROINTESTINAL DISEASE Referred to as gastrointestinal diseases, they are common disorders which affect the esophagus,
6/19/2017 OBJECTIVES. Describe the proposed mechanism(s) between the gut microbiome and psychiatric disease.
OBJECTIVES Describe the proposed mechanism(s) between the gut microbiome and psychiatric disease. List psychiatric diseases that have been associated with alterations in gut microbiota. Describe the strength
Probiotics in IBS. Dr. Partha Pratim Das Associate Professor Dhaka Medical college
Probiotics in IBS Dr. Partha Pratim Das Associate Professor Dhaka Medical college Definitions Probiotics: Live microorganisms that confer a health benefit on the host when administered in adequate amounts.
10/4/2014. The Microbiome vs. the Gastroenterologist. Human Microbiome. Microbiome and Host Physiology: A Delicate Balance
The Microbiome vs. the Gastroenterologist John K. Marshall MD MSc FRCPC AGAF Division of Gastroenterology McMaster University Human Microbiome Mouth Finlay BB. Scientific American 2010;302:56-63 Microbiome
PROBIONA. PROBIOTICS with 5 bacterial strains. Suitable during and after the use of antibiotics to restore intestinal microflora.
PROBIONA Probiotic supplement for adults PROBIOTICS with 5 bacterial strains Suitable during and after the use of antibiotics to restore intestinal microflora. 2.850 billion cfu per capsule guaranteed
Mashhad University of Medical Sciences. Azita Ganji MD, MPH
Mashhad University of Medical Sciences Azita Ganji MD, MPH 30.2.95 CD Food sensitivity (NCGS, ) Food intolerance IBS Gluten translocate through the epithelial mucosa via increased tight junction (TJ)
Alterazioni età correlate del microbiota intestinale e fragilità Francesco Landi, MD, PhD Catholic University, Gemelli Hospital, Rome, Italy
Alterazioni età correlate del microbiota intestinale e fragilità Francesco Landi, MD, PhD Catholic University, Gemelli Hospital, Rome, Italy Aging and muscle Loss of muscle mass, strength and function
Page: 1 of 7. Fecal Analysis in the Diagnosis of Intestinal Dysbiosis
Page: 1 of 7 Last Review Status/Date: June 2015 Description Intestinal dysbiosis may be defined as a state of disordered microbial ecology that is believed to cause disease, including conditions such as
Beyond the Scope: The Microbiome & The Future of Gastroenterology
Beyond the Scope: The Microbiome & The Future of Gastroenterology Robynne Chutkan, MD, FASGE Digestive Center for Wellness, LLC MedStar Georgetown University Hospital Rapid Identification of Microbes
Beyond the Scope: An Integrative Gastroenterologist s Approach to Digestive Disorders
Beyond the Scope: An Integrative Gastroenterologist s Approach to Digestive Disorders Robynne Chutkan, MD, FASGE Digestive Center for Wellness, LLC MedStar Georgetown University Hospital The real voyage
Fecal Microbiota Transplantation for Severe sepsis and Diarrhea : a Case Report
Fecal Microbiota Transplantation for Severe sepsis and Diarrhea : a Case Report Qiurong Li Institute of General Surgery, Jinling Hospital Nanjing Univeristy Gut Microbiota 100 trillion cells 10-fold of
Study summaries L. casei 431
This binder provides you with summaries of selected publications on Lactobacillus paracasei subsp. paracasei L. casei 431. The publications are clinical studies performed in humans documenting the effects
4/17/2019 DISCLOSURES OBJECTIVES GI MICROBIOME & HEALTH: A REVIEW. Nancy C. Kois, MD, FCAP Contemporary Pathology Services. There are no disclosures
GI MICROBIOME & HEALTH: A REVIEW Nancy C. Kois, MD, FCAP Contemporary Pathology Services DISCLOSURES There are no disclosures OBJECTIVES Definitions: GI microbiota, GI microbiome, probiotic, prebiotic
Probiotics. Wide spectrum of important health benefits
Probiotics Part 1: What Are Probiotics? Probiotics are live microorganisms that inhabit the respiratory and gastrointestinal tracts and the skin. They are often referred to as friendly bacteria as they
Module Four: The GI System Module Five: The Gut Microbiome. The GI System. LLiana Shanti, CN
Module Four: The GI System Module Five: The Gut Microbiome The GI System LLiana Shanti, CN www.healthmasteryinstitute.com Review Review Review The Gut Hippocrates has been quoted as saying death sits in
The Intestinal Microbiota and the Developing Immune System
The Intestinal Microbiota and the Developing Immune System 4 Feb 2016 The Intestinal Microbiota 10 fold more bacterial cells than human cells 100-1000 fold more bacterial genes than human genes Why does
Abdominal Bloating and Distension: What Is the Role of the Microbiota
Dig Dis Sci (2012) 57:4 8 DOI 10.1007/s10620-011-1834-4 REVIEW Abdominal Bloating and Distension: What Is the Role of the Microbiota B. Issa N. A. Wafaei P. J. Whorwell Received: 12 April 2011 / Accepted:
Irritable bowel syndrome and probiotics: from rationale to clinical use Elena F. Verdu and Stephen M. Collins
Irritable bowel syndrome and probiotics: from rationale to clinical use Elena F. Verdu and Stephen M. Collins Purpose of review Few therapies are of proven efficacy in irritable bowel syndrome. Thus, there
The long-term impact of the low-fodmap diet for management of irritable bowel syndrome. Dr Miranda Lomer RD.
The long-term impact of the low-fodmap diet for management of irritable bowel syndrome Dr Miranda Lomer RD Email: miranda.lomer@kcl.ac.uk What is IBS - ROME IV Criteria A functional bowel disorder in which
Probiotics for Disease Prevention and Amelioration. Neerja Hajela, PhD Yakult Danone India Pvt. Ltd.
Probiotics for Disease Prevention and Amelioration Neerja Hajela, PhD Yakult Danone India Pvt. Ltd. Microbiology turns inwards Human Metagenome project and Meta Hit project reveals that the gut micro flora
Diagnosis and Management of Irritable Bowel Syndrome (IBS) For the Primary Care Provider
Diagnosis and Management of Irritable Bowel Syndrome (IBS) For the Primary Care Provider Elizabeth Coss, MD General Gastroenterologist Audie Murphy Veterans Hospital UT Health This presentation does not
THE ROLE OF MICROBIOME IN IBD
Disclosures THE ROLE OF MICROBIOME IN IBD Janssen UCB No relevance to the talk Subra Kugathasan, MD Professor of Pediatrics & Human Genetics Marcus Professor of Pediatric Gastroenterology Emory University
2/3/2011. Adhesion of Bifidobacterium lactis HN019 to human intestinal
PROBIOTICS LEARNING THE WHY AND WHEN PROBIOTICS DEFINITION live micro-organisms organisms that are beneficial to the host organism WHO: Live organisms which, when administered in adequate amounts, confer
Probiotics. Gastrointestinal Health & Disease. in conjunction with American College of Gastroenterology Annual Scientific Meeting
X E C U E T I V E P R O C E E D I N G S Symposium in conjunction with American College of Gastroenterology Annual Scientific Meeting Probiotics Applications in Gastrointestinal Health & Disease Made Possible
Role of the Gut Microbiota in Autoimmunity
Role of the Gut Microbiota in Autoimmunity Pavan Bhargava, MD - Neuroimmunology Fellow Division of Neuroimmunology and Neurological Infections Johns Hopkins University, Baltimore, MD. May, 2015 None Disclosures
Irritable bowel syndrome (IBS) and chronic idiopathic constipation
CLINICAL AND SYSTEMATIC S nature publishing group 1547 see related editorial on page 1563 CME Efficacy of Prebiotics, Probiotics, and Synbiotics in Irritable Bowel Syndrome and Chronic Idiopathic Constipation:
Fonterra Probiotics: From guts to glory
Fonterra Probiotics: From guts to glory James Dekker April 16, 2015 Host Institution Probiotic bacteria Live micro-organisms which, when administered in adequate amounts, confer a health benefit on the
Disorders in which symptoms cannot be explained by the presence of structural or tissue abnormalities Irritable bowel syndrome Functional heartburn Functional dyspepsia Functional constipation Functional
Q What are Probiotics?
Q What are Probiotics? The word PROBIOTIC was originated from Latin and means For Life. Probiotics are good bacteria usually found in food products or supplements which play very important roles in regulating
Targeting the Intestinal Microbiota in the Treatment of Functional Gastrointestinal Disorders
Targeting the Intestinal Microbiota in the Treatment of Functional Gastrointestinal Disorders Yehuda Ringel, MD. Professor of Medicine Chief, Division of Gastroenterology Rabin Medical Center, Beilinson
Next generation of probiotics
Session: Evaluating next generation ingredients to support digestive health Wednesday 23 rd November 2016 Next generation of probiotics Louise R Wilson RD PhD Assistant Science Manager, Yakult UK Ltd LWilson@yakult.co.uk
Probiotics: Their Role in Medicine Today. Objectives. Probiotics: What Are They? 11/3/2017
Probiotics: Their Role in Medicine Today Viki Barr Pharm.D., BCPS AQ ID Assistant Professor, Pharmacy Practice Rosalind Franklin University of Medicine and Science Clinical Pharmacist, Infectious Diseases
WEBINAR Microbial Metabolism Associated with Health. 12 April 2018; CET
WEBINAR Microbial Metabolism Associated with Health 12 April 2018; 15.00-16.30 CET PROGRAMME Brief Introduction of Both Organisations and Scientific Background Dr Bettina Schelkle (ILSI Europe, BE) Dr
HUMAN GUT MICROBIOTA
HUMAN GUT MICROBIOTA Patrizia Brigidi Department of Pharmaceutical Sciences, University of Bologna, Italy patrizia.brigididi@unibo.it The Gut-Liver axis: a bidirectional relation in health and disease
Today s talk 21/05/2017. Microbiota: the consequence of evolution! Probiotics and mucosal immunity interactions in early life.
Europe Probiotics and mucosal immunity interactions in early life Almere, 09 Mei, 2017 Today s talk The dynamics of the microbiota The required signals from the environment Not all signals (probiotics!)
Annex III. Amendments to relevant sections of the Product Information
Annex III Amendments to relevant sections of the Product Information Note: These amendments to the relevant sections of the product information are the outcome of the referral procedure. The product information
Microbiome as Predictor of Benefit and Toxicity in Cancer Immunotherapy
Microbiome as Predictor of Benefit and Toxicity in Cancer Immunotherapy Giuliana Magri, Ph.D Optimizing Immunotherapy New Approaches, Biomarkers, Sequences and Combinations PRBB Auditorium, Barcelona October
The Gut Microbiota: Evidence For Gut Microbes as Contributors to Weight Gain
The Gut Microbiota: Evidence For Gut Microbes as Contributors to Weight Gain Michael T. Bailey, Ph.D. Center for Microbial Pathogenesis The Research Institute, Nationwide Children s Hospital Department
Prevention of Infantile Colic Using Probiotics
Prevention of Infantile Colic Using Probiotics Authors: *Hamid Ahanchian, 1,2 Asma Javid 3 1. Children s Health and Environment Program, Queensland Children s Medical Research Institute, University of
Emerging Probiotic Research: A Guide to the Use of Probiotics in Clinical Practice
Emerging Probiotic Research: A Guide to the Use of Probiotics in Clinical Practice Donald Brown, ND April 13, 2010 Probiotics WHO Definition: Live microorganisms, which when administered in adequate amounts,
Probiotics: Targeting obesity
Probiotics: Targeting obesity Azadeh Nadjarzadeh, PhD in Nutrition Nutrition and Food Security Research Centre, Shahid Sadoughi University of Medical Sciences, Yazd, Iran azadehnajarzadeh@gmail.com Among
Annamaria Staiano. Il terreno su cui si semina: Immunità e Microbiota
Annamaria Staiano Il terreno su cui si semina: Immunità e Microbiota Il terreno su cui si semina: Immunità e Microbiota Outline Sviluppo e composizione del microbiota intestinale Fattori che influenzano
Long-term Clinical Course of Post-infectious Irritable Bowel Syndrome After Shigellosis: A 10-year Follow-up Study
JNM J Neurogastroenterol Motil, Vol. 22 No. 3 July, 2016 pissn: 2093-0879 eissn: 2093-0887 http://dx.doi.org/10.5056/jnm15157 Original Article Long-term Clinical Course of Post-infectious Irritable Bowel
Pro- and prebiotics as modulators of gut microbiome in management of obesity and metabolic diseases. Sampo Lahtinen, DuPont Nutrition & Health
Pro- and prebiotics as modulators of gut microbiome in management of obesity and metabolic diseases Sampo Lahtinen, DuPont Nutrition & Health 25 Jan 2016 Active Nutrition R&D team - Kantvik, Finland Characteristics
11/2/2016. Objectives. Definition of probiotics. What is and what is not a probiotic? What is and what is not a probiotic?
A Consumer s Guide to Probiotics and Health Wellness Wednesday November 2, 2016 Wendy Dahl RD PhD FDC Associate Professor, Food Science and Human Nutrition, UF/IFAS Objectives To outline current evidence
Name of Policy: Fecal Analysis in the Diagnosis of Intestinal Dysbiosis
Name of Policy: Fecal Analysis in the Diagnosis of Intestinal Dysbiosis Policy #: 407 Latest Review Date: December 2016 Category: Laboratory/Pathology Policy Grade: C Background/Definitions: As a general
Microbiome. The Gut Microbiome function 3/6/2018. Use of probiotics for management of various GI conditions
Use of probiotics for management of various GI conditions Lina Kay PA-C Arizona Gastroenterology Associates Scottsdale, AZ Microbiome Human GI tract hosts countless microbes (estimate 100 trillions bacteria
NEL RISPETTO DELLE NUOVE DISPOSIZIONI IN MATERIA DI ECM, A SEGUITO DELL ATTUAZIONE DELL ACCORDO STATO-REGIONI DEL 5/11/09 E SUCCESSIVE
NOME E NUMERO DEL PROVIDER: I&C SRL - 5387 ECM N : 180726 TITOLO: XVII CONGRESSO NAZIONALE GISMAD SEDE: MILANO, HOTEL NHOW DATA: 09-10/03/2017 NEL RISPETTO DELLE NUOVE DISPOSIZIONI IN MATERIA DI ECM, A
Aminosalicylates. Giovanni Barbara. Department of Medical and Surgical Sciences Alma Mater Studiorum, University of Bologna, Italy ( )
Aminosalicylates Giovanni Barbara Department of Medical and Surgical Sciences Alma Mater Studiorum, University of Bologna, Italy (1088 2016) Colonic Diverticula, a Painless Ageing Change? 20% develop symptoms