Public health preparedness and response
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1 EXECUTIVE BOARD EB14/9 14nd session January 018 Provisional agenda item 3.3 Public health preparedness and response WHO s work in health emergencies Report by the Director-General 1. This report is submitted pursuant to requests in resolution EBSS3.R1 (015) and decision WHA68(10) (015). It streamlines WHO s reporting on its work in health emergencies, updating reports on coordination and response in large-scale emergencies, and the development of the Research and Development Blueprint for Action to Prevent Epidemics for potentially epidemic diseases. WHO S RESPONSE AND COORDINATION IN SEVERE, LARGE-SCALE EMERGENCIES. The WHO Health Emergencies Programme has established a system for continuous event-based surveillance of public health events and verification and assessment of detected events: on average, 3000 signals are received per month, of which 300 merit follow-up and evaluation of those leads to 30 being investigated. Standardized risk assessment processes are used and their application has ensured better coordination between the three levels of the Organization. The Programme has also developed new standard packages of care for high-priority high-impact pathogens and diseases including cholera, Zika and influenza. These packages are linked to comprehensive training and learning packages for 15 diseases and cross-cutting technical interventions, with 0 online training units. To underpin key technical responses, new administrative systems have been put in place, including pre-cleared staff rosters for deployments, emergency standard operating procedures, including delegations of authority, fast-track recruitments and procurement. Additionally, the second edition of WHO s Emergency Response Framework, 1 which includes application of the Incident Management System, is now used to manage all graded events. 3. During the period from 1 January to 0 October 017, WHO responded to 47 graded emergencies in more than 40 countries and territories (see Annex). These included WHO Grade 3 emergencies and United Nations Inter-Agency Standing Committee Level 3 and other large-scale emergencies. The Director-General has made no new declaration of public health emergency of international concern in 017. At the beginning of 017, WHO s operations were targeting 1 WHO: Emergency response framework, nd edn. Geneva: World Health Organization; 017 ( accessed 3 November 017).
2 EB14/ million people for humanitarian assistance, 1 although this number has progressively risen with new outbreaks and emergencies throughout the year. 4. Among the acute (graded and ungraded) emergencies, nine were classified Grade 3 emergencies, which is the highest severity level based on WHO s Emergency Response Framework, requiring a significant response from WHO and mobilization of substantial Organization-wide support for the collective response with partners in the field (see the Table). Out of these, three complex humanitarian crises (in South Sudan, Nigeria and Ethiopia) were later categorized as Protracted Grade 3 emergencies (persisting for more than six months, as defined in the Emergency Response Framework), for which a sustained WHO operational presence and response are still required on a major scale. The Grade 3 emergencies in the, Iraq, Syrian Arab Republic and Yemen are also Inter-Agency Standing Committee system-wide Level 3 emergencies, in which governments, United Nations agencies and civil society partners work together to meet response needs. Table. Summary of WHO s activation of Grade 3 emergencies between 1 January and 0 October 017 (in chronological order of activation date) Country WHO region Grade 3 activation date Status as of 0 October 017 Syrian Arab Republic 3 January 013 Ongoing South Sudan African 1 February 014 Protracted Grade 3 Iraq 1 August 014 Ongoing Yemen 1 July 015 Ongoing Nigeria African 19 August 016 Protracted Grade 3 Ethiopia African 0 April 017 Protracted Grade 3 Somalia 9 May 017 Ongoing of the Congo African 9 August 017 (Kasai region) and 13 October (for whole country) Ongoing Bangladesh/Myanmar South-east Asia 8 October 017 Ongoing 5. In accordance with the principles of the Emergency Response Framework, WHO activated the Incident Management System to fulfil its six critical functions and scaled up its operational and technical support so as to address immediately the health needs of and risks facing the affected population. Working with partners, the Secretariat supported national governments efforts in life-saving interventions to increase the quality and coverage of health services, strengthen primary and secondary health and hospital care by operating mobile teams and health facilities, improve surveillance and early warning systems, conduct vaccination campaigns, distribute medicines and supplies, and train health workers. WHO also led or jointly led health sector coordination, including that of 3 activated health clusters. These actions were supported by the rapid release of funds from WHO s Contingency Fund for Emergencies: about US$ 16 million have been disbursed in 017 up to 0 October in order to ensure rapid expansion of WHO s response in 8 graded emergencies. 1 This figure is derived from the Inter-Agency Standing Committee s Humanitarian Response Plans. Leadership, partnership coordination, information and planning, health operations and technical expertise, operations support and logistics, and finance and administration.
3 EB14/9 6. Constraints on the health sector response in these major crises include continuing insecurity and limited access, limited capacities of national health systems and partners, shortages of health personnel, bureaucratic constraints and insufficient funding. During the biennium , WHO has requested US$ 1070 million in appeals funding (that is, for outbreak and crisis response) to respond to emergencies and health crises, of which it has received US$ 848 million (79%) Over the course of the reporting period, the African Region experienced further deterioration of the humanitarian and health situation across several countries, and tackled prolonged conflicts and disease outbreaks. The major events triggering substantive WHO operations included: the food famine/pre-famine crisis across the Horn of Africa; the conflict and displacement in the north-eastern part of Nigeria; and the deteriorating humanitarian and health situations in South Sudan and. Major outbreaks also requiring a scaled-up WHO response included Ebola virus disease and cholera in, plague in Madagascar, Marburg virus disease in Uganda, yellow fever and malaria in Nigeria, malaria in Cabo Verde and necrotizing cellulitis in Sao Tome and Principe For each of these emergencies, WHO applied the Incident Management System and ensured the provision of priority Emergency Response Framework deliverables. Detailed operational reviews were undertaken for Ethiopia, Nigeria and South Sudan. 8. The Region continued to experience an intensification of humanitarian and health emergencies in Iraq, Somalia, Syrian Arab Republic and Yemen. In these countries, the operating environment remained volatile with insecurity, limited access and frequent attacks on health care. In the Syrian Arab Republic, WHO has provided sufficient medicines and supplies for 10.5 million treatments (8.4 million from inside the country), and vaccinated 4.5 million children against measles and.4 million children against polio. WHO s response to the cholera outbreak in Yemen included establishment of 36 diarrhoea treatment centres and 138 oral rehydration corners, support for treatment of suspected cases of cholera and delivery of emergency health supplies. In response to the Mosul crisis in Iraq WHO, in collaboration with Ninewa health authority and partners, provided trauma care to patients, coordinated and supported primary care services for more than one million consultations, and coordinated vital vaccination activities. In Somalia, cholera treatment centres have been established in 40 districts to manage cases of severe acute watery diarrhoea or cholera. 9. In response to the large-scale influx of more than refugees fleeing violence in Myanmar s Rakhine State to Cox s Bazar in Bangladesh, WHO has mobilized more than 40 national and international staff from all three levels of the organization. Priority health interventions have included preventive campaigns against measles ( children vaccinated) and cholera (an oral cholera vaccination campaign for people launched), the establishment of an early warning alert and response system, strengthening of health sector coordination, and rapid expansion of access to essential health services, including 0 mobile teams supported by WHO. 10. Other large-scale emergencies for which WHO supported the national response during the reporting period included the yellow fever outbreak in Brazil (Grade ), Hurricanes Irma and Maria in the Caribbean (Grade ) and the ongoing humanitarian crisis in Ukraine (Grade ). 1 Figures from the WHO Programme Budget Portal ( accessed on 14 November 017). 3
4 EB14/9 11. The interrelated issues of safeguarding our health security while promoting our health through universal health coverage are WHO s top priority. Outbreaks are inevitable, but epidemics are preventable. Strong health systems are our best defence to prevent disease outbreaks from becoming epidemics and to mitigate the risks caused by the breakdown of health systems in fragile settings, such as those caused by conflict. The Secretariat, through the WHO Health Emergencies Programme, will continue to work with Member States to build the alert and response systems for effective detection and responses and to build stronger national public health and health care systems that are based on principles of universal access, readiness and resilience. RESEARCH AND DEVELOPMENT IN THE CONTEXT OF EMERGENCIES 1. In June 015, the Secretariat initiated work on the Research and Development Blueprint for Action to Prevent Epidemics for potentially epidemic diseases. Its goal is to reduce delays between the identification of an outbreak and the deployment of effective medical interventions to save lives and minimize socioeconomic disruption. Areas covered by the Blueprint include product research and development for diagnostics, vaccines and therapeutics. 13. The following paragraphs provide details of new developments since an earlier version of this report, which was noted by the Seventieth World Health Assembly in May Accelerating research and development processes: revision of the list of priority diseases and road maps for research and development 14. WHO s list of diseases for priority research and development was updated at a meeting in January 017 and will be reviewed at a consultation that will take place on 5 and 6 February The Secretariat has developed six vaccine target product profiles and two diagnostic target product profiles and is working on target product profiles for other key pathogens. The Secretariat and partners are developing research and development road maps for prioritized diseases through expert consultations. The first road map for Middle East respiratory syndrome coronavirus is scheduled to be updated following a recent joint FAO/OIE/WHO technical meeting Following the Director-General s declaration on 1 February 016 of a Public Health Emergency of International Concern in regard to the clusters of microcephaly cases and other neurological disorders reported in Brazil, the Secretariat rapidly triggered a series of research and development actions. 4 An initial workshop on Zika vaccine efficacy trials was organized (Geneva, 1 and June 017). Generic protocols for Zika vaccine evaluation are being finalized together with criteria for prioritization of vaccine candidates and selection of clinical sites. 1 See document A70/10 and summary records of the Seventieth World Health Assembly of Committee A, first meeting (section 3), second meeting (section 3), third meeting (section 3) and fourth meeting (section 1). WHO Research and Development Blueprint. 017 Annual review of diseases prioritized under the Research and Development Blueprint: informal consultation, Geneva, 4 and 5 January 017: meeting report ( accessed 3 November 017). 3 FAO-OIE-WHO Global technical meeting on MERS-CoV (Geneva, 5 7 September 017). 4 Zika R&D ( accessed 3 November 017). 4
5 EB14/9 17. The Secretariat, working with experts, is developing, and will publish methodological guidelines, decision-making tools, models and generic protocols to evaluate vaccine efficacy during outbreaks. In addition, the Secretariat will convene in Utrecht (the Netherlands) a first consultation in December 017 to initiate the development of tools and materials to evaluate therapeutics for use during outbreaks. Stakeholder coordination 18. In 017, the establishment of the Global Coordination Mechanism for Research and Development to Prepare for and Respond to Epidemics was finalized. In November 017, its terms of reference and core membership were discussed and standard operating procedures for regular communication among members and interaction with existing independent advisory groups of experts informing the global research and development community were outlined. The Secretariat has also developed a visualization tool to facilitate access to information on stakeholders involved in research on various priority pathogens and products. 19. The Coalition for Epidemic Preparedness Innovations, with which WHO signed a memorandum of understanding in September 016, has committed itself to working on the diseases prioritized in the R&D Blueprint and according to the critical characteristics identified in WHO s target product profiles. One example of collaboration was the accelerated development by the Secretariat of target product profiles for vaccines against Lassa fever, Nipah virus and Middle East respiratory syndrome coronavirus in order to aid the Coalition s first call for proposals. Regulatory capacity 0. Efforts to strengthen national regulatory and ethics bodies to respond to public health emergencies are under way. In May 017, the Secretariat held an informal consultation on options to improve regulatory preparedness to address public health emergencies for vaccines, diagnostics and therapeutics for priority pathogens. A confidentiality agreement to share the diagnostic assessment data, pending approval from manufacturers, on Zika virus diagnostics dossiers submitted through the WHO Emergency Use Assessment and Listing procedure was signed between WHO and the Brazilian Health Regulatory Agency. ACTION BY THE EXECUTIVE BOARD 1. The Board is invited to note this report. 5
6 EB14/9 ANNEX LIST OF ACTIVE GRADED EMERGENCIES IN THE REPORTING PERIOD (1 JANUARY 0 OCTOBER 017) Country/territory Region Date of initial Bangladesh/ Myanmar Somalia Type of crisis Initial grade South-East Asia 08/10/017 Rakhine conflict 3 African 9/08/017 Kasai region/acute humanitarian crisis 09/05/017 Complex emergency/drought/ cholera outbreak 3 Ethiopia African 0/04/017 Severe acute watery diarrhoea/cholera outbreak 3 Nigeria (north-east) African 18/08/016 Complex emergency Yemen Iraq 01/07/015 Complex emergency/ cholera outbreak 3 Date of last Latest grade 3 13/10/017 Grade /08/017 Protracted Grade 3 01/06/017 Protracted Grade 3 1/08/014 Conflict/civil strife 3 6/08/015 Grade 3 South Sudan African 1/0/014 Conflict/civil strife 3 01/05/017 Protracted Grade 3 Syrian Arab Republic 03/01/013 Conflict/civil strife 3 5/08/015 Grade 3 Madagascar African /09/017 Plague Caribbean islands Americas 18/09/017 Hurricanes Irma and Maria Cabo Verde African 11/09/017 Malaria outbreak Myanmar South-East Asia 1/06/017 Conflict/civil strife Sudan Sao Tome and Principe African 15/05/017 Ebola virus disease outbreak 4/04/017 Drought/food insecurity African 14/0/017 Necrotizing cellulitis Brazil Americas 01/0/017 Yellow fever outbreak Libya United Republic of Tanzania African 3/06/016 Cholera outbreak 03/03/016 Armed conflict escalation African 15/1/015 Refugee crisis/cholera outbreak 11/06/017 Protracted Grade 3/08/017 Protracted Grade 17/05/017 Grade 3/08/017 Protracted Grade Niger African 01/04/015 Conflict/civil strife 01/05/017 Protracted Grade Cameroon African 01/04/015 Conflict/civil strife 01/05/017 Protracted Grade 6
7 Annex EB14/9 Country/territory Region Date of initial Central African Republic Type of crisis Initial grade Date of last Latest grade African 03/06/015 Conflict/civil strife 01/05/017 Protracted Grade Ukraine European 0/0/014 Conflict/civil strife 1/0/015 Grade Saudi Arabia All regions 01/06/014 Multi-state outbreak of Middle East respiratory syndrome coronavirus African 0/07/013 Complex emergency 01/05/017 Protracted Grade Chad African 15/09/017 Cholera outbreak 1 Pakistan 30/08/017 Dengue outbreak 1 Nepal South-East Asia 18/08/017 Floods 1 Sierra Leone African 16/08/017 Mudslides and flooding 1 Myanmar South-East Asia 31/07/017 Influenza A(H1N1) outbreak 1 Philippines Western Pacific 9/07/017 Marawi conflict 1 Burundi African 06/07/017 Malaria outbreak 1 Sri Lanka South-East Asia 05/07/017 Dengue outbreak 1 Bangladesh South-East Asia 07/06/017 Cyclone Mora 1 Sri Lanka South-East Asia 9/05/017 Floods 1 Kenya African 0/04/017 Drought/food insecurity 1 Uganda African 13/04/017 Drought/food insecurity 1 Peru Americas 05/04/017 Floods 1 Angola African 08/0/017 Cholera outbreak 1 Chad African 06/01/017 Hepatitis E outbreak 1 Papua New Guinea Western Pacific 31/05/016 Complex emergency 1 06/06/017 Grade 1 West Bank and Gaza Strip Afghanistan 05/11/015 Conflict/civil strife 1 17/05/017 Grade 1 8/10/015 Displacement 1 17/05/017 Grade 1 Mali African 16/10/015 Complex emergency 1 01/05/017 Protracted Grade 1 Pakistan 0/06/014 Displacement 1 17/05/017 Grade 1 = = = 7
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