Immunization Update & focus on meningococcal vaccine PART 2
|
|
- Scot Powell
- 6 years ago
- Views:
Transcription
1 Immunization Update & focus on meningococcal vaccine PART 2 Gregory Hussey Vaccines for Africa Initiative Institute of Infectious Diseases University of Cape Town
2 Meningococcal Disease in South Africa
3 Incidence of MeningococcalDisease MemishA, GoubeaudA, Broker M, MalerczykC, ShiblA. Invasive Meningococcal disease and travel.journal of Infection and Public Health (2010) 3,
4 African Meningitis Belt cases
5 Meningococcal carriage rates are low during infancy and peak at 19 Years of Age 1 Young adults are the most common source of transmission to the community 2 Up to 10% of adolescents and adults are asymptomatic transient carriers 3 Prevalence (%) Meta-analysis of 89 Studies in 28 Countries 1 Fitted data Range of 95% CI Age 1 Christensen H. Lancet Infect Dis. 2010;10(12):853; 2 Pelton SI. PediatrInfect DisJ. 2009;28(4):329; 3 CDC. In: Epidemiology and Prevention of Vaccine-Preventable Diseases. (The Pink Book.) 12th ed
6 Clinically significant serogroups Poland. CID 2010
7 Global Neisseria meningitidis Serogroup Distribution Has Been Varied, Making Trends Unpredictable CANADA 1 EUROPE 5 15% 57% USA 2 14% 74% TURKEY 6 JAPAN 11 13% 40% 33% 18% 33% 60% 18% SAUDI ARABIA 7 TAIWAN 10 21% 57% COLOMBIA 3 15% 15% 70% BRAZIL 4 69% 19% AFRICAN MENINGITIS BELT 8 11% 79% 37% 26% 48% AUSTRALIA 12 ARGENTINA 4 55% 38% 15% 21% 13% 42% SOUTH AFRICA 9 27% 74% NEW ZEALAND 13 31% 58% A B C W X Y Represents serogroups not defined for each individual country 1. National Advisory Committee on Immunization (NACI). Can Commun Dis Rep. 2013;36(ACS-1):1-40; 2. Centers for Disease Control and Prevention (CDC). Active bacterial core surveillance report, emerging infections program network, Neisseria meningitidis, Centers for Disease Control and Prevention (CDC) website. 3.Neisseriameningitidis(aislaminetosinvasores). Instituto Nacional de la Salud. Grupo de Microbiologia. Dec2012; 4. Informe Regional de SIREVA II, Washington, DC: Organización Panamericana de la Salud; 2013; 5. European Centre for Disease Prevention and Control (ECDC). Surveillance of invasive bacterial diseases in Europe, Stockholm: ECDC; 2013; 6. Ceyhan M, et al. Poster presented at: 31st Annual Meeting of the European Society for Paediatric Infectious Diseases (ESPID); May 28-June 1, 2013; Milan, Italy; 7. Al-Mazrou YY, et al. Saudi Med J. 2004;25: ; 8. Intercountry Support Team -West Africa Week 49-52, World Health Organization website. Meningitis Weekly Bulletin von Gottberg, A. Comm Dis Surveill Bull. 2012;10:60-63; 10. Vyse A, et al. Epidemiol Infect. 2011;139: ; 11. Takahashi H, et al. J Med Microbiol. 2004;53: ; 12. Lahra MM, et al. Commun Dis Intell. 2012;36:E ; 13. Lopez L, et al. The Epidemiology of Meningococcal Disease in New Zealand in Institute of Environmental Science and Research Ltd (ESR); Slide courtesy of Novartis
8 Percentage of cases 100% 90% 80% 70% 60% 50% 40% 30% 20% 10% MenWhas become the predominant cause of meningococcal disease South Africa, B C W Y A Other/NG* Unknown 0% N= N= N= N= N= N= N= N= N= N= N= N=340 *May include serogroups e.g., X, E, Z, or non-groupable; Serogroup not identified; Year spans August through July. Serogroup data from viable isolates and PCR results Year 2012 N= Coulson GB, et al. Meningococcal Disease in South Africa, Emerg Infect Dis. 2007;13: ; data from GERMS-SA national surveillance, NICD, NHLS Slide adapted from Novartis
9 Number of casesof laboratory-confirmed meningococcal disease in South Africa reported to GERMS-SA by month and year, 2003 to 2012 (n=4537) Cases Deaths Number of cases Number of cases Year Number of deaths Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec Month 2003 (n=445) 2004 (n=412) 2005 (n=604) 2006 (n=666) 2007 (n=502) 2008 (n=460) 2009 (n=463) 2010 (n=415) 2011 (n=340) 2012 (n=230) Ackn: AvG, NICD
10 Incidenceof invasive meningococcal disease by age category, South Africa, 2003 to 2012 (n=4308, age unknown for 229 cases) 14 Incidence (per population) <1yr 1-4yrs 5-9yrs 10-14yrs 15-24yrs 25-44yrs 45-64yrs >64yrs Year Ackn: AvG, NICD
11 Case-fatality ratio of invasive meningococcal disease by age category, South Africa, (n=1560) 100% 90% 80% Recovered Died 70% 60% 50% % 30% 20% 10% 0% < >64 Age category (in years) Ackn: AvG, NICD
12 HIV prevalence among patients with invasive meningococcal disease, and population HIV prevalence, 2012, South Africa National HIV prevalence 2012 < MCD risk in patients with AIDS. Harris CM et al Open Forum Inf Diseases 2016 Incidence of MCD in AIDS patients 25 to 64 years olds was 3.5 cases per person years (95% confidence interval [CI], ), compared with 0.3 cases per person years (95% CI, ) for persons of the same age group not reported to have AIDS (relative risk = 12.9; 95% CI, ). Cohen C, Singh E, Wu HM et al. AIDS2010;24: ; and updated data. Ackn: AvG, NICD
13 Meningoccocal vaccine development time line Holst et al. Human Vaccines & Immunotherapeutics 9:6, ; June 2013
14 Poland. CID 2010
15 Conjugate vaccines Monovalent Serogroups Manufacturer Age indications Mengitec MenC-CRM Pfizer 2 Months Menjugate MenC-CRM Novartis 2 Month NeisVac-C MenC-TT Baxter 2 Months MenAfrivac Men A-TT Combination Serum Institute India years MenHibrix Hib-MenCY-TT GSK 6 wks 18 mths Menitorix Hib-MenC-TT GSK 6 wks 18 mths Booster 1-2 yrs
16 Conjugate vaccines Quadrivalent Serogroups Manufacturer Age indications Menveo MenACWY-CRM Novartis yrs(1 dose) 7-23 mths(2 doses) 2 Mths(4 doses) Nimenrix MenACWY-CRM GSK Pfizer Month (1 dose) NmVac4 MenACWY-DT JN IntMed Corp 9Months? Menactra MenACWY-DT SP yrs(1 dose) 9-23 mths(2 doses)
17 MenC Conjugate Australia MenC in 2003, with a catch-up campaign between 2003 and 2007 for all children aged 1-19 years. July 2013, NIP -Hib & MenC at 12 mths. Ireland MenC in 2000; infants were given three doses before 1 year of age, with a catch-up programme in adolescents. 2013, NIP 3 doses: 3 months (MenC), months (Hib & MenC), and years (Men C) England and Wales -MenC introduced in 1999, with a catch up campaign in children up to 19 years of age. NIP -two dose schedule at 3 and 12 months of age. Andrews & Pollard - LID2014;14:
18
19 Impact of MenA vaccine in Chad. Dougla et al. Lancet 2013
20
21 CTC 40 c 4 dys
22 SerogroupB vaccines Bexsero (Novartis) & Trumenba (Pfizer) USA routinely used for year olds. 2 dose regimen. Bexsero was introduced into the routine UK schedule on 1st September The vaccine is given at 2 and 4 months, with a booster at 12 months.
23 Meningococcal vaccines registered in SA Currently there are 2 types of meningococcal vaccines available in South Africa Apolysaccharide vaccine (Menomune, Sanofi Pasteur (MPSV4) Aprotein-conjugate polysaccharide vaccine (Menactra, Sanofi Pasteur (MCV4). These are both quadrivalent vaccines targeting the polysaccharide capsules of serogroups A, C, W and Y.
24
25 MCV recommendations - 1 Group Recommendation Doses Booster Hajj pilgrims and travellers to Saudi Travellers to meningitis belt or other areas where disease is hyperendemic/epidemic Research/reference laboratory workers routinely exposed to N. meningitidis Persons with medical conditions at high risk of acquiring infection: Complement component deficiencies and asplenic conditions Required Single primary dose A booster dose every 3 years for MPSV4 or 5 years for MCV4 is required for repeated travel as per current Saudi regulations Recommended Single primary dose Booster dose every 5 years should be considered for repeated travel to highly endemic areas Recommended Single primary dose Booster dose every 5 years if risk remains Recommended Two-dose primary schedule 12 weeks apart Booster dose every 5 years
26 MCV recommendations 2 Should be considered Population group Primary dosing Booster Healthy children and infants Healthy adolescents or young adults entering university or college (particularly if staying in hostels) Military recruits on training or deployment Miners Attendees of mass gatherings Children 9 months to 23 months: 2 doses 12 weeks apart Children 24 months: 1 dose Single dose prior to entry into university or college Single dose prior to commencing training or deployment Single primary dose Single primary dose Booster dose required if risk remains high 5 years after primary dose HIV infection Other immunocompromising conditions Two-dose primary schedule 12 weeks apart Two-dose primary schedule 12 weeks apart Booster every 5 years Booster every 5 years
27 Menactra & GBS NO Note: A 2003 study concluded that people who received the 1976 swine influenza vaccine had a small increased risk for developing GBS.
28 AEFI Adverse Reaction Co- Incidental Vaccine Immunisation
29 CIOMS/ WHO cause specific definition of AEFIs 1 Vaccine productrelated reaction 2 Vaccine quality defectrelated reaction 3 Immunization error-related reaction 4 Immunization anxietyrelated reaction 5 Coincidental event An AEFI that is caused or precipitated by a vaccine due to one or more of the inherent properties of the vaccine product. An AEFI that is caused or precipitated by a vaccine that is due to one or more quality defects of the vaccine product including its administration device as provided by the manufacturer. An AEFI that is caused by Inappropriate vaccine handling, prescribing or administration. An AEFI arising from anxiety about the immunization. An AEFI that is caused by something other than the vaccine product, immunization error or immunization anxiety
30 What adverse effects do vaccines or immunisation cause? Side effect Common > 1% and < 10% Rare >0.01% and < 0.1% Reaction Very rare < 0.001% and< Expected Unexpected Unexpected Examples Fever ISR # Rash Febrile convulsion BCG adenitis ISR - Abscess Urticaria/Angioede ma # ISR - Injection Site Reaction Thrombocytopenia Hypotonic hyporesponsive episodes (HHE) Anaphylaxis
31 -The Global Advisory Committee on Vaccine Safety (GACVS) was established in 1999 to respond promptly, efficiently, and with scientific rigour to vaccine safety issues of potential global importance. -The Committee provides independent, authoritative, scientific advice to WHO on vaccine safety issues of global or regional concern with the potential to affect in the short or long term national immunization programmes
32
ESCMID Online Lecture Library
What would be the best schedule for prevention of meningococcal disease in all ages? Ray Borrow ray.borrow@phe.gov.uk Public Health England, Manchester, UK MCC vaccine programme - UK In November 1999,
More informationAdolescent vaccination strategies
Adolescent vaccination strategies Gregory Hussey Vaccines for Africa Initiative Institute of Infectious Diseases & Molecular Medicine University of Cape Town www.vacfa.uct.ac.za gregory.hussey@uct.ac.za
More informationHemagglutinin Neuraminidase
Evolving Vaccine Guidance: Influenza, Meningococcal & HPV Vaccines H. Cody Meissner, M.D. Professor of Pediatrics Tufts University School of Medicine Maine Chapter AAP Bar Harbor, Maine October 16, 2016
More informationQ21. Where can I find more information on meningococcal disease and vaccines?
FREQUENTLY ASKED QUESTIONS This fact sheet provides responses to some common questions about meningococcal vaccines, focusing on quadrivalent meningococcal conjugate vaccines (4vMenCVs). More detailed
More informationExperience with Quadrivalent Meningococcal Conjugate Vaccines (MenACWY) in Adolescent Vaccine Programs in the United States and Canada
Experience with Quadrivalent Meningococcal Conjugate Vaccines (MenACWY) in Adolescent Vaccine Programs in the United States and Canada Jessica MacNeil, MPH Epidemiologist Centers for Disease Control and
More informationBacterial diseases caused by Streptoccus pneumoniae in children
Bacterial diseases caused by Streptoccus pneumoniae in children Bactermia 85% Bacterial pneumonia 66% Bacterial meningitis 50% Otitis media 40% Paranasal sinusitis 40% 0% 10% 20% 30% 40% 50% 60% 70% 80%
More informationMeningococcal Disease in Travellers
Meningococcal Disease in Travellers Please find product Prescribing Information at the end of this presentation Meningococcal disease A rare but potentially serious illness in travellers1 Caused by the
More information9/12/2018. Meningococcal Disease and Meningococcal Vaccine. Neisseria meningitidis. Meningococcal Disease Pathogenesis. Aerobic gram-negative bacteria
Centers for Disease Control and Prevention National Center for Immunization and Respiratory Diseases Meningococcal Disease and Meningococcal Vaccine Adult Track Chapter 14 Photographs and images included
More informationSee Spot Run Meningococcal update 2017
See Spot Run Meningococcal update 2017 Jim Buttery Infection and Immunity Monash Children s Hospital Monash Health Monash University SAEFVIC How serious a disease is N meningitidis? Meningococcal disease
More informationBACTERIAL MENINGITIS IN CHILDREN
Overview Bacterial meningitis in children : rare, severe, mostly preventable What should GPs advise Australian parents in 2018? Peter McIntyre Professorial Fellow, National Centre for Immunisation Research
More informationVaccines. Robert Read University of Southampton University Hospital Southampton
Vaccines Robert Read University of Southampton University Hospital Southampton Disclosures Non personal, non specific; Novartis-GSK Member, JCVI Editor in Chief, Journal of Infection, and Current Opinion
More informationKeeping up with the immunization schedule: Meningococcal and More
Keeping up with the immunization schedule: Meningococcal and More DatTran, MD, MSc, FRCPC, FAAP Division of Infectious Diseases, The Hospital for Sick Children Department of Paediatrics, University of
More informationNational Institute for Communicable Diseases -- Weekly Surveillance Report --
Weekly Surveillance Report Week 43, 216 National Institute for Communicable Diseases -- Weekly Surveillance Report -- Page 2 Laboratory-Based Respiratory & Meningeal Disease Surveillance 3 Neisseria meningitidis
More information2/16/2015 IMMUNIZATION UPDATE Kelly Ridgway, RPh February 21, Today s Overview NEW RECOMMENDATIONS
IMMUNIZATION UPDATE 2015 Kelly Ridgway, RPh February 21, 2015 Today s Overview 1 2 3 4 5 6 Pneumococcal Vaccine Recommendations Meningococcal Vaccine Recommendations HPV Vaccine Recommendations Patient
More informationInvasive Meningococcal Disease - prevention through vaccination
Invasive Meningococcal Disease - prevention through vaccination Dr Shamez Ladhani Paediatric Infectious Diseases Consultant Public Health England Email: shamez.ladhani@phe.gov.uk a pain you cannot describe
More informationChanges to the Meningococcal C conjugate (MenC) vaccine schedule. Questions and Answers
Changes to the Meningococcal C conjugate (MenC) vaccine schedule Questions and Answers Background The meningococcal C (MenC) vaccination programme was first introduced into the UK routine immunisation
More informationThe Burden, Epidemiology and Prevention of Meningococcal Disease in Kenya
The Burden, Epidemiology and Prevention of Meningococcal Disease in Kenya Ombeva Malande Vaccinologist/Paed infectious diseases Specialist Lecturer Makerere/Egerton University 27th April 2017 17th KPA
More informationChanges to the meningococcal C conjugate (MenC) vaccine schedule 2014 first-time university entrants under the age of 25
Changes to the meningococcal C conjugate (MenC) vaccine schedule 2014 first-time university entrants under the age of 25 An update for registered healthcare practitioners August 2014 Quality Education
More informationS404- Meningococcal Vaccines: Updated Policy Statement 2014
S404- Meningococcal Vaccines: Updated Policy Statement 2014 Michael T. Brady, MD Associate Medical Director Nationwide Children s Hospital Columbus, Ohio Disclosure of Relevant Relationship Dr. Brady (or
More informationMENINGITIS WHAT S NEW? 3 RD NOVEMBER 2018
MENINGITIS WHAT S NEW? 3 RD NOVEMBER 2018 CONFLICTS OF INTEREST Educational travel grant - Gilead JIM NEWCOMBE FRCPA FRACP ID PHYSICIAN, ROYAL NORTH SHORE HOSPITAL, SYDNEY CLINICAL MICROBIOLOGIST, DOUGLASS
More informationDevelopment of a Group A meningococcal conjugate vaccine for sub-saharan Africa: clinical trial results
Development of a Group A meningococcal conjugate vaccine for sub-saharan Africa: clinical trial results Global Immunization Meeting 2009, United Nations HQ New York City, February 2009 MenA conjugate vaccine
More informationWHAT S NEW WITH VACCINATIONS IN 2016?
WHAT S NEW WITH VACCINATIONS IN 2016? MenB and a Few Other Changes Lynn Bahta, RN, PHN Immunization Clinical Consultant Minnesota Department of Health May 2016 Disclosure No conflict of interest Will discuss
More informationHyporesponsiveness: Time To Stop Using Meningococcal Polysaccharide Vaccines?
Hyporesponsiveness: Time To Stop Using Meningococcal Polysaccharide Vaccines? Lee H. Harrison, M.D. Professor of Medicine and Epidemiology University of Pittsburgh First Regional Meningococcal Symposium
More informationDisclosure Statement. Encapsulated Bacteria. Functions of the Spleen 10/25/2017. Pharmacist Learning Objectives
Pharmacist Learning Objectives No Spleen? No Problem. A Review of Vaccinations Indicated for the Asplenic Patient SCSHP Fall Meeting October 26, 2017 Explain the rationale for vaccinations in Select the
More informationACIP Recommendation Update. Mark H. Sawyer, MD UCSD School of Medicine Rady Children s Hospital San Diego
ACIP Recommendation Update Mark H. Sawyer, MD UCSD School of Medicine Rady Children s Hospital San Diego What has ACIP been up to lately? New Recommendations Tdap vaccination for each pregnancy Meningococcal
More informationChanges to the meningococcal C conjugate (MenC) vaccine schedule 2014 first-time university entrants under the age of 25 An update for registered
Changes to the meningococcal C conjugate (MenC) vaccine schedule 2014 first-time university entrants under the age of 25 An update for registered healthcare practitioners Frequently asked questions August
More informationMeningococcal disease and vaccination in the UK
Meningococcal disease and vaccination in the UK Ray Borrow Professor of Vaccine Preventable Diseases, Vaccine Evaluation Unit, Health Protection Agency, Manchester Royal Infirmary, Manchester, U.K. ray.borrow@hpa.org.uk
More informationPediatric and Adolescent Vaccines
Pediatric and Adolescent Vaccines Andrea A. Berry, M.D. Division of Infectious Diseases and Tropical Pediatrics Center for Vaccine Development & Division of Malaria Research Overview Pediatric vaccine
More informationImmunization Update: New CDC Recommendations. Blaise L. Congeni M.D. 2012
Immunization Update: New CDC Recommendations Blaise L. Congeni M.D. 2012 Polysaccharide Vaccines Vaccine Hib capsule polysaccharide PRP (polyribose ribitol phosphate) Not protective in infants
More informationHans Jürgen Dornbusch
Epidemiology of Invasive Meningococcal Disease Hans Jürgen Dornbusch Infectious Vaccination Disease Working Working Group Group Severe bacterial infections Pneumococcus Haemophilus influenzae b 3 rd World!
More informationIntroduction of a meningococcal ACWY immunisation programme for adolescents
Introduction of a meningococcal ACWY immunisation programme for adolescents Information for registered healthcare practitioners Acknowledgement: This resource has been adapted with the permission of Public
More informationInvasive meningococal diseasefocus on Meningococcal B - epidemiology, international and Ireland
Invasive meningococal diseasefocus on Meningococcal B - epidemiology, international and Ireland Dr Suzanne Cotter, Health Protection Surveillance Centre (HPSC) Scope presentation Meningococccal disease
More informationPrevention of Meningococcal Disease. Marco Aurélio P. Sáfadi, MD, PhD FCM da Santa Casa de São Paulo
Prevention of Meningococcal Disease Marco Aurélio P. Sáfadi, MD, PhD FCM da Santa Casa de São Paulo Outline of the presentation Brief overview on the burden of MD Lessons learned with plain polysaccharide
More information31/10/2017 COI. Travel Vaccination Update. Outline. General Advice. Steffen graph: travel epi. Checklist. Current nil
Travel Vaccination Update COI Current nil Nigel Crawford HealthEd, Brisbane October 2017 Historical pharmaceutical industry funding to my research institute (MCRI) for special risk and vaccine safety projects
More informationImmunization Guidelines for the Use of State Supplied Vaccine May 17, 2015
DTaP / DT DTaP/IPV/Hep B Combination (Pediarix ) Children from 6 weeks of age up to the 7 th birthday Children from 2 months of age up to the 7th birthday: Indicated for the primary doses of DTaP, IPV,
More informationPneumococcal vaccination in UK: an update. Dr Richard Pebody Immunisation Department Health Protection Agency Centre for Infections
Pneumococcal vaccination in UK: an update Dr Richard Pebody Immunisation Department Health Protection Agency Centre for Infections Leading infectious causes of mortality, 2000 WHO estimates 3.5 Deaths
More informationGlobal Burden of Meningococcal Disease. Prof. David Salisbury CB FRCP FRCPCH FFPH FMedSci. Centre for Global Health Security, Chatham House, London.
Global Burden of Meningococcal Disease Prof. David Salisbury CB FRCP FRCPCH FFPH FMedSci. Centre for Global Health Security, Chatham House, London. Neisseria meningitidis Gram negative diplococci. Ten
More informationPHAA Immunisaton Conference. Adelaide 5-7 June 2018
PHAA Immunisaton Conference Adelaide 5-7 June 2018 Good Public Health Messaging Reporting back Cold Chain Nurse Practitioner Immunisation Cold Chain Use of and access to thermostability data has been
More informationInvasive Meningococcal Disease - prevention through vaccination
Invasive Meningococcal Disease - prevention through vaccination Dr Shamez Ladhani Paediatric Infectious Diseases Consultant Public Health England Email: shamez.ladhani@phe.gov.uk a pain you cannot describe
More information1.3 Meningococcal Disease (Neisseria meningitidis) (invasive)
1.3 Meningococcal Disease (Neisseria meningitidis) (invasive) Summary Number of cases, 214: 82 Number of cases, 213: 81 Number of cases, 212: 66 Crude incidence rate, 214:1.8/1, Between and 212, a marked
More informationNational Immunisation Programme changes Michael Baker. Wessex Public Health England Centre
National Immunisation Programme changes 2013-14 Michael Baker Wessex Public Health England Centre Changes to the Meningococcal serogroup C conjugate (MenC) vaccine schedule in 2013 2 Immunisation Programme
More informationReview Article Conjugate Meningococcal Vaccines Development: GSK Biologicals Experience
SAGE-Hindawi Access to Research Advances in Preventive Medicine Volume 2011, Article ID 846756, 17 pages doi:10.4061/2011/846756 Review Article Conjugate Meningococcal Vaccines Development: GSK Biologicals
More informationWe have a new vaccine: Now what are we going to do with it? Prof. David Salisbury CB FRCP FRCPCH FFPH FMedSci
We have a new vaccine: Now what are we going to do with it? Prof. David Salisbury CB FRCP FRCPCH FFPH FMedSci Pressures for new vaccine introduction. International institutions. Vaccine manufacturers National
More informationShelter-based Meningococcal Disease Outbreak: Working together to treat and vaccinate
Shelter-based Meningococcal Disease Outbreak: Working together to treat and vaccinate Barbara Giles, MSN, RN April Donahue, BSN, RN Denise De Las Nueces, MD, MPH Boston Health Care for the Homeless Program
More informationThe legally binding text is the original French version TRANSPARENCY COMMITTEE OPINION. 21 October 2009
The legally binding text is the original French version TRANSPARENCY COMMITTEE OPINION 21 October 2009 MENINGITEC suspension for injection in prefilled syringes meningococcal group C oligosaccharide conjugate
More informationVACCINES-WHAT HAS HAPPENED IN THE LAST YEAR. Mark H. Sawyer UCSD School of Medicine Rady Children s Hospital San Diego
VACCINES-WHAT HAS HAPPENED IN THE LAST YEAR Mark H. Sawyer UCSD School of Medicine Rady Children s Hospital San Diego LOTS HAS HAPPENED AND IT CAN BE A LITTLE CONFUSING Some people can get 2 doses of HPV
More informationVaccines for infants- What has happened in the last year?
Vaccines for infants- What has happened in the last year? MARK H. SAWYER UCSD SCHOOL OF MEDICINE RADY CHILDREN S HOSPITAL SAN DIEGO Lots has happened and it can be a little confusing Infants used to require
More informationPrivate Market Vaccines
Private Market Vaccines 1 What do you recommend Best protection for my child Best protection for adults Best protection for occupational health 2 Not on the national schedule.. Rotavirus Varicella Meningococcal
More informationMeningococcal Update. Disclosure. Meningococal and Influenza Vaccines Update! Robert Wittler, MD Sept 12, 2014 KAAP Fall CME Meeting
1 Meningococal and Influenza Vaccines Update! Robert Wittler, MD Sept 12, 2014 KAAP Fall CME Meeting 2 Disclosure Speakers Bureau: Sanofi Pasteur Vaccines and Novartis! I do not intend to discuss an unapproved/
More informationMeningococci and meningococcal disease
Australian Technical Advisory Group on Immunisation (ATAGI) Statement Advice for immunisation providers regarding the use of Bexsero a recombinant multicomponent meningococcal B vaccine (4CMenB) March
More informationGlobal and National Trends in Vaccine Preventable Diseases. Dr Brenda Corcoran National Immunisation Office.
Global and National Trends in Vaccine Preventable Diseases Dr Brenda Corcoran National Immunisation Office Global mortality 2008 Children under 5 years of age 1.5 million deaths due to vaccine preventable
More informationNHS public health functions agreement Service specification No.6 Meningococcal C (MenC) containing vaccine immunisation programme
NHS public health functions agreement 2018-19 Service specification No.6 Meningococcal C (MenC) containing vaccine immunisation programme 1 NHS public health functions agreement 2018-19 Service specification
More informationChanges to the meningococcal C conjugate (MenC) vaccine schedule Information for healthcare professionals
Changes to the meningococcal C conjugate (MenC) vaccine schedule 2013-2015 Information for healthcare professionals 1 About Public Health England Public Health England s mission is to protect and improve
More informationMeningococcal Vaccine ICG stockpile 2016
Meningococcal Vaccine ICG stockpile 2016 The Meningitis Vaccine Project - Closure Conference Addis Ababa 22-23 February 2016 Myriam Henkens MSF Alejandro Costa WHO 1 International Coordinating Group (ICG)
More informationDecision-making for introduction of meningococcal vaccines in the face of changing meningococcal epidemiology
Decision-making for introduction of meningococcal vaccines in the face of changing meningococcal epidemiology Wiebke Hellenbrand Frankfurt, November 1, 2016 Evidence-based approach to vaccination recommendations
More informationSerogroup W in Africa & travellers
Serogroup W in Africa & travellers Muhamed-Kheir TAHA Institut Pasteur 01/11/2016 2 childhood meningococcal meningitis caused by this serogroup. Three infants, two with bacteremia and one with septic arthritis
More informationSource: Portland State University Population Research Center (
Neisseria meningitidis Surveillance Report 2009 Oregon Active Bacterial Core Surveillance (ABCs) Office of Disease Prevention & Epidemiology Oregon Health Authority Updated: June 2011 Background The Active
More informationSeries of 2 doses, 6-12 months apart. One dose is 720 Elu/0.5ml (GSK) or 25 u/0.5 ml (Merck)
UTAH PREVENTIVE CARE RECOMMENDATIONS Adult - Ages 19 and Above IMMUNIZATIONS CONTENTS: General Instructions Hepatitis A Hepatitis B Human Papilloma Virus Influenza Meningococcal A, C, Y, W (MCV4) Meningococcal
More informationSplenectomy Vaccine Protocol PIDPIC
Splenectomy Vaccine Protocol PIDPIC 6.24.14 Rationale Spleen clears encapsulated bacteria and infected erythrocytes Serves as one of the largest lymphoid tissues where B cells are educated against encapsulated
More informationAdult Pneumococcal Disease
Adult Pneumococcal Disease Reviewed and updated July 2018 S. pneumoniae and pneumococcal disease The bacterium Streptococcus pneumoniae causes pneumococcal disease S. pneumoniae is commonly found in human
More information2017 Vaccination Update
2017 Vaccination Update NATHAN BOONSTRA, MD General Pediatrician, Blank Pediatric Clinic TODAY S OBJECTIVES Review the latest recommendations for immunizations, including HPV Meningococcal vaccines Influenza
More informationMeningococcal Disease Information and Investigation Guidelines
Meningococcal Disease Information and Investigation Guidelines Table of Contents: 1) Disease Description... 2 2) Infectious Agent... 2 3) Symptoms... 2 4) Incubation Period... 2 5) Incidence... 3 6) Transmission...
More informationImpact and effectiveness of national immunisation programmes. David Green, Nurse Consultant, Immunisations Public Health England
Impact and effectiveness of national immunisation programmes David Green, Nurse Consultant, Immunisations Public Health England Session objectives Immunisation planning and implementation The impact and
More information- Infanrix hexa (DTPa-HBV-IPV/Hib): GSK Biologicals combined diphtheria, tetanus, acellular pertussis, hepatitis
The study listed may include approved and non-approved uses, formulations or treatment regimens. The results reported in any single study may not reflect the overall results obtained on studies of a product.
More informationMeningococcal Conjugate (Groups A, C, Y and W-135) Vaccine Biological Page
Meningococcal Conjugate (Groups A, C, Y and W-135) Vaccine Biological Page Section 7: Biological Product Information Standard #: 07.281 Created by: Approved by: Province-wide Immunization Program Standards
More informationChange history Version number Change details Date Updated for National ACWY programme to be implemented August June 2015.
Patient Group Direction for Conjugate Meningococcal ACWY vaccine Version: MEN ACWY CONJUGATE 2015.1 Start 1 st August 2015 Expiry 31 st July 2018 THIS PATIENT GROUP DIRECTION HAS BEEN AGREED BY THE FOLLOWING
More informationMeningococcal Education Program for Quebec Physicians: How Results Have Changed 2 Years after the Initial Program
Meningococcal Education Program for Quebec Physicians: How Results Have Changed 2 Years after the Initial Program Marc H. Lebel, MD, FRCPC John Yaremko, MD, FRCPC Anne Dionne, MD, FRCPC Anne-Julie Gaudreau,
More informationA Licensed Combined Haemophilus influenzae Type b- Serogroups C and Y Meningococcal Conjugate Vaccine
Infect Dis Ther (2013) 2:1 13 DOI 10.1007/s40121-013-0007-5 REVIEW A Licensed Combined Haemophilus influenzae Type b- Serogroups C and Y Meningococcal Conjugate Vaccine Kirsten P. Perrett Terry M. Nolan
More informationREFERENCE CODE GDHC1013FPR PUBLICAT ION DATE AUGUST 2013 MENINGOCOCCAL VACCINES - CURRENT AND FUTURE PLAYERS
REFERENCE CODE GDHC1013FPR PUBLICAT ION DATE AUGUST 2013 MENINGOCOCCAL VACCINES - Executive Summary Meningococcal Vaccines: Key Metrics in the Nine Major Pharmaceutical Markets 2012 Epidemiology Targeted
More informationAndrew Kroger, MD, MPH National Center for Immunization and Respiratory Diseases MCH & Immunization Conference Anchorage, AK September 28, 2010
2010 Immunization Update Andrew Kroger, MD, MPH National Center for Immunization and Respiratory Diseases MCH & Immunization Conference Anchorage, AK September 28, 2010 Disclosures No financial conflict
More informationMeningococcal Disease and College Students
MASSACHUSETTS PUBLIC HEALTH FACT SHEET Meningococcal Disease and College Students May 2018 Page 1 of 4 What is meningococcal disease? Meningococcal disease is caused by infection with bacteria called Neisseria
More informationIn February 2015, the Joint Committee on Vaccination and Immunisation (JCVI) *
Background In 2015, Public Health England (PHE) reported a continued increase in meningococcal serogroup W cases in England. The rise was initially recorded in 2009 and since this time, cases have steadily
More informationDownloaded from:
Christensen, H; Trotter, CL; Hickman, M; Edmunds, WJ (2014) Re-evaluating cost effectiveness of universal meningitis vaccination (Bexsero) in England: modelling study. BMJ (Clinical research ed), 349.
More informationMulticomponent MenB Vaccine (4CMenB): An Innovative Step In the Global Fight Against Serogroup B Meningococcal Disease
Multicomponent MenB Vaccine (4CMenB): An Innovative Step In the Global Fight Against Serogroup B Meningococcal Disease Jeffrey J. Stoddard, MD, FAAP Head, Global Medical Affairs Novartis Vaccines and Diagnostics
More informationWould a combined PCV10+PCV13 immunization schedule be a cost-effective option for Canadian children?
Would a combined PCV10+PCV13 immunization schedule be a cost-effective option for Canadian children? Philippe De Wals Department of Social and Preventive Medicine, Laval University Quebec University Hospital
More informationOutsourcing in Clinical Trials 1-2 July 2015
Outsourcing in Clinical Trials 1-2 July 2015 Innovating Dr Chris Bailey Babraham Research Campus Babraham Cambridge CB22 3AT UK +44 (0)1223 496115 Vaccines www.immbio.com 1 Utilising Academia for the Benefit
More informationCONJUGATE MENINGOCOCCAL (ACWY) VACCINE
Cumbria & Lancashire Vaccine PGD Group ADVISORY INFORMATION FOR USE WITH PATIENT SPECIFIC DIRECTION OR INDIVIDUAL PRESCRIPTION SIGNED BY GP OR NON-MEDICAL PRESCRIBER. CONJUGATE MENINGOCOCCAL (ACWY) VACCINE
More informationTRANSPARENCY COMMITTEE OPINION. 4 March 2009
The legally binding text is the original French version TRANSPARENCY COMMITTEE OPINION 4 March 2009 MENCEVAX powder and solvent for solution for injection Meningococcal polysaccharide vaccine for serogroups
More informationWHO position paper on meningococcal vaccines
WHO position paper on meningococcal vaccines Geneva, Switzerland Published in WER Nov 2011 Epidemiology of meningococcal disease In most countries Neisseria meningi+dis is a leading cause of meningi)s
More informationBabyJabs Vaccines. All vaccines are mercury-free We use aluminium-free vaccines wherever possible
BabyJabs Vaccines All vaccines are mercury-free We use aluminium-free vaccines wherever possible BabyJabs is a dedicated children s immunisation service, offering a choice of single and small combination
More informationInvasive Meningococcal Disease - prevention through vaccination
Invasive Meningococcal Disease - prevention through vaccination Dr Shamez Ladhani Paediatric Infectious Diseases Consultant Public Health England Email: shamez.ladhani@phe.gov.uk Vaccines against MenB
More informationNOTE: The above recommendations must be read along with the footnotes of this schedule.
Figure 1. Recommended immunization schedule for persons aged 0 through 18 years 2013. (FOR THOSE WHO FALL BEHIND OR START LATE, SEE THE CATCH-UP SCHEDULE [FIGURE 2]). These recommendations must be read
More informationInvasive meningococcal disease
SURVEILLANCE REPORT Annual Epidemiological Report for 2015 Invasive meningococcal disease Key facts In 2015, 3 121 confirmed cases of invasive meningococcal disease were reported by 30 EU/EEA Member States
More informationREFERENCE CODE GDHC1155DFR PUBLICAT ION DATE SEPTEMBER 2013 NIMENRIX (MENINGOCOCCAL VACCINES) FORECAST AND MARKET ANALYSIS TO 2022
REFERENCE CODE GDHC1155DFR PUBLICAT ION DATE SEPTEMBER 2013 NIMENRIX (MENINGOCOCCAL VACCINES) Executive Summary Nimenrix: Key Metrics in the Nine Major Pharmaceutical Markets 2012 Market Sales US 5EU Japan
More informationHAEMOPHILUS INFLUENZAE INVASIVE DISEASE
23 Annual Morbidity Report HAEMOPHILUS INFLUENZAE INVASIVE DISEASE CRUDE DATA 35 Annual Incidence a LA County.37 California b. United States c.2 Age at Diagnosis Mean 4. years Median 36. years Range Birth
More informationUpdate on Meningococcal A Vaccine Development and Introduction
Update on Meningococcal A Vaccine Development and Introduction WHO Product Development for Vaccines Advisory Committee Meeting (PD-VAC) @ Geneva, 7-9 September 2015 Dr Marie-Pierre Preziosi, WHO Initiative
More informationMeningitis January Dr Andrew Lee Consultant in Communicable Disease Control, PHE Information in this slide set was correct as of 21.1.
Meningitis January 2016 Dr Andrew Lee Consultant in Communicable Disease Control, PHE Information in this slide set was correct as of 21.1.16 Outline What is meningitis What causes it What are the signs
More informationIntroduction. Infections acquired by travellers
Introduction The number of Australians who travel overseas has increased steadily over recent years and now between 3.5 and 4.5 million exits are made annually. Although many of these trips are to countries
More informationMENINGOCOCCAL MENINGITIS 101. An Overview for Parents, Teachers, Students and Communities
MENINGOCOCCAL MENINGITIS 101 An Overview for Parents, Teachers, Students and Communities 2013 Meningococcal Disease Fast Facts Meningococcal disease is the result of a rare, but serious bacterial infection
More information3 rd dose. 3 rd or 4 th dose, see footnote 5. see footnote 13. for certain high-risk groups
Figure 1. Recommended immunization schedule for persons aged 0 through 18 years 2013. (FOR THOSE WHO FALL BEHIND OR START LATE, SEE THE CATCH-UP SCHEDULE [FIGURE 2]). These recommendations must be read
More informationBabyJabs Vaccines. All vaccines are mercury- free We use aluminium- free vaccines wherever possible
BabyJabs Vaccines All vaccines are mercury- free We use aluminium- free vaccines wherever possible BabyJabs is a dedicated children s immunisation service, offering a choice of single and small combination
More informationPre- Travel Case Studies (*with Key Pads)
Pre- Travel Case Studies (*with Key Pads) Judi Piasecki, RN, BN Dana Male, RN, BN Pam White RN, BN Certificate in Travel Health A. Which year was the first Manitoba Travel Health Conference? 1. 1999 2.
More informationVaccination Decision Making: What Providers Need to Know
Objectives Vaccination Decision Making: What Providers Need to Know Kelli Smith, RN, BSN Iowa Department of Public Health Immunization Program Catch-up Schedule: how to most efficiently bring persons up-to-date
More informationVaccinating special risk groups/responding to outbreaks. VACCSline
Vaccinating special risk groups/responding to outbreaks 2016 Protecting vulnerable persons Raise awareness of recommendations for certain patients Apply this to own workplace when developing immunisation
More informationINVASIVE MENINGOCOCCAL DISEASE (IMD), BACTERIAL/VIRAL MENINGITIS & HAEMOPHILUS INFLUENZAE INFECTIONS IN IRELAND
INVASIVE MENINGOCOCCAL DISEASE (IMD), BACTERIAL/VIRAL MENINGITIS & HAEMOPHILUS INFLUENZAE INFECTIONS IN IRELAND A REPORT BY THE HEALTH PROTECTION SURVEILLANCE CENTRE IN COLLABORATION WITH THE IRISH MENINGITIS
More informationThe Immunisation Service s at the Royal Children s Hospital. Sonja Elia Nurse Practitioner and Manager Immunisation
The Immunisation Service s at the Royal Children s Hospital Sonja Elia Nurse Practitioner and Manager Immunisation The Immunisation Service Three core services Drop-in centre Telephone advice line Weekly
More informationPEDIATRIC PHARMACOTHERAPY A Monthly Newsletter for Health Care Professionals from the University of Virginia Children s Hospital
PEDIATRIC PHARMACOTHERAPY A Monthly Newsletter for Health Care Professionals from the University of Virginia Children s Hospital Volume 17 Number 10 October 2011 M An Update on Quadrivalent Meningococcal
More informationImmunization Update. William Atkinson, MD, MPH. Immunization Action Coalition
Immunization Update William Atkinson, MD, MPH Immunization Action Coalition Coordinated School Health Conference Lake Ozark, Missouri December 3, 2016 1 Disclosures William Atkinson has no financial relationships
More informationNew Jersey Department of Health Vaccine Preventable Disease Program Childhood and Adolescent Recommended Vaccines
New Jersey Department of Health Vaccine Preventable Disease Program Childhood and Adolescent Recommended Vaccines Antigens Vaccine Approved Age Daptacel Diphtheria, Tetanus, and acellular Pertussis (DTaP)
More information