Improving Adult Vaccination
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1 Improving Adult Vaccination Protecting our Most Vulnerable Dale W. Bratzler, DO, MPH Principal Clinical Coordinator
2 Do the vaccines work? Myth: Vaccines don t work in hospitalized patients.
3 3 Missed Opportunities Influenza vaccine is immunogenic in hospitalized patients and patients with chronic renal failure Pneumococcal vaccine approximately 50-75% effective preventing invasive disease Berry BB et al. Vaccine. 2001;19: Brydak LB et al. Vaccine. 2000;18: Christenson B, et al. Lancet. 2001;357: Nichol KL, et al. Arch Intern Med. 1999;159: Nichol KL. Vaccine. 1991;17(suppl 1):S91-S93.
4 4 Influenza Vaccination Reductions in Hospitalization and Death 32% 19% 16% 23% 48% 2 yr study of elderly members of 3 HMO s & seasons with > 140,000 persons in each year s cohort Nichol KL, et al. N Engl J Med. 2003;348:
5 5 Benefits of Pneumococcal Vaccinations Group All Elderly Persons 1 Effectiveness / Cost Savings Bacteremias 75% (57% to 85%) Cost savings Elderly w/ Chronic Lung Disease 2 $8.27 per person Hospitalizations for pneumonia 43% (16% to 62%) Deaths 29% (9% to 44%) Cost savings 1 Sisk J. JAMA 1997; 278: Nichol KL. Arch Intern Med 1999; 159: $294 per person
6 6 Effectiveness of Pneumococcal Vaccination in Older Adults: The VSD Cohort Study 3 year cohort study of 47,365 members of Group Health Coop (Seattle) PPV was associated with lower rates of bacteremia: HR 0.56 (95% CI ) PPV was not associated with lower rates of community acquired pneumonia HR 1.07 (95% CI ) HR = hazard ratio. Jackson LA, et al. NEJM 2003; 348: 1747.
7 7 Do the vaccines work?? All agree, we need more effective vaccines Influenza vaccines that can be produced more rapidly after identification of a viral strain
8 What about immunosuppressed patients? Myth: We shouldn t vaccinate immunosuppressed patients.
9 9 Missed Opportunities Immunocompromised persons PPV HIV, leukemia, lymphoma, Hodgkins ds, multiple myeloma, malignancy, those receiving immunosuppressive chemotherapy, and those who have received an organ or bone marrow transplant Influenza Immunosuppression caused by medications or by HIV CDC. MMWR. 1997;46(RR-8):1-24. CDC. MMWR. 2003;52(RR-8):1-36.
10 Is Vaccination Safe? Myth: Vaccination is not safe for patients in the hospital. (vaccination can make me sick)
11 11 Missed Opportunities Myth: Hospital Vaccination is Not Safe Many hospital and emergency department-based vaccination programs have been safely and effectively implemented with no evidence of significant risk Klein RS, et al. Arch Intern Med. 1983;143: (hospital pneumococcal vaccine) Magnussen CR, et al. Arch Intern Med. 1984;144: (hospital and ambulatory pneumococcal vaccine) Bloom HG, et al. J Am Geriat Soc. 1988;36: (hospital influenza and pneumococcal vaccines) Crouse BJ, et al. J Fam Pract. 1994;38: (hospital-based influenza vaccination) Nichol KL, et al. Am J Med. 1998;105: (10-year experience with inpatient influenza and pneumococcal vaccination) Rodriquez RM, et al. Ann Emerg Med. 1993;22: (ER-based influenza and pneumococcal vaccination) Slobodkin D, et al. Vaccine. 1998;16: (Inner-city ER-based influenza and pneumococcal vaccination)
12 12 Missed Opportunities Vaccine Side Effects Post-injection Symptoms in Elderly Receiving Influenza Vaccine.* Vaccine (%) Placebo (%) P value Fever Cough Fatigue Malaise Myalgia Sore arm <0.001 Any symptom *Margolis KL, Nichol KL, Poland GA, Pluhar RE. Frequency of adverse reactions to influenza vaccine in the elderly. A randomized, placebo-controlled trial. JAMA. 1990;264:
13 13 Missed Opportunities Vaccine Side Effects Systemic Symptoms Experienced Before and After Pneumococcal Vaccination.* Pre-vaccination (%) Post-vaccination (%) P value Fever Rash <0.01 Myalgias <0.01 Fatigue <0.01 Malaise <0.01 Headache <0.01 Overall health (same as usual) <0.01 *Nichol KL, Mac Donald R, Hauge M. Side effects associated with pneumococcal vaccination. Am J Infect Control. 1997;25:
14 14 Vaccination Reality in the US The Why.. Despite the fact that influenza and pneumococcal vaccines are: clinically effective cost effective safe, and free to most elderly patients They are under-utilized!
15 Why should we vaccinate hospitalized patients?
16 16 Rationale for Hospital-based Influenza Vaccination Age Group Population Discharged during the flu season Subsequent P&I hospitalizations* Subsequent P&I deaths* Y N N (%) % % ,540 8,046 (3) ,120 6,439 (3) ,664 4,811 (6) > 75 44,138 5,188 (12) *Proportion of the population with subsequent hospitalization or death from pneumonia or influenza who had been discharged from a hospital. Fedson DS, Houck P, Bratzler D. [Editorial] Infect Control Hosp Epidemiol. 2000;21:
17 17 Missed Opportunities Background Fedson DS, et al. Infect Control Hosp Epidemiol. 2000;21:
18 18 Why give them in the hospital? Failure to vaccinate hospitalized patients is a missed opportunity Hospitalized patients may be at particularly risk of subsequent complications of influenza and pneumococcal disease
19 19 Is Hospital-based Vaccination the Standard of Care? CMS and JCAHO have adopted influenza and pneumococcal vaccination of inpatients as measures of hospital quality PPV written into the MMA as a publicly reported measure of quality Hospital Compare Recommended by ACIP, IDSA, and others
20 20 PN-2: Pneumococcal Vaccination Numerator Patients with pneumonia, age 65 and older, who were screened for pneumococcal vaccine status and were vaccinated prior to discharge, if indicated Denominator Pneumonia patients 65 years of age and older Key Exclusions Transfers from another acute care facility, no working diagnosis of pneumonia on admission, patients receiving comfort care only, expired in hospital, left AMA, discharged to hospice care, transferred to another hospital
21 21 PN-7: Influenza Vaccination Numerator Patients discharged during October through February with pneumonia, age 50 and over, who were screened for influenza vaccine status and were vaccinated prior to discharge, if indicated Denominator Pneumonia patients 50 years and older Key Exclusions Transfers from another acute care facility, no working diagnosis of pneumonia on admission, patients receiving comfort care only, expired in hospital, left AMA, discharged to hospice care, diagnosis of influenza, transferred to another acute care hospital
22 22 Additional Measure Notes We exclude patients who have had a bone marrow transplantation within the past year and patients actively receiving chemotherapy or radiation therapy Influenza vaccine not available this variable is only allowed when there is a national shortage of vaccine
23 23 Results Influenza Take home still no documentation in 61% of patients! Percent Vaccinated Prior to Arrival Contraindicated Refused 10/ / / / / / / /2004 Proportion of Medicare patients discharged with a discharge diagnosis of pneumonia that were screened for or vaccinated prior to discharge.
24 24 Results Pneumococcal Take home still no documentation in 58.8% of patients! Percent Vaccinated Prior to Arrival Contraindicated Refused 07/ / / / / / / /2004 Proportion of Medicare patients discharged with a discharge diagnosis of pneumonia that were screened for or vaccinated prior to discharge.
25 25 Where are we at now? Targeted efforts to measure performance and promote quality improvement on hospital-based vaccination have resulted in improved documentation of patient vaccination status
26 26 Where are we at now?.however Overall rates of inpatient vaccination have only marginally improved There is no information on vaccination status for more than half of the Medicare patients discharged from the hospital
27 27 Where are we at now? Refusals and contraindications accounted for a small proportion of the improvement in vaccination/screening documentation in Medicare patients
28 28 Where s the greater risk of liability??
29 29 Where is the liability risk? Liability cases in three states Very consistent theme Young males who have previously had a splenectomy (no documentation of PPV) Subsequently hospitalized (in some, multiple times) not given PPV At least one case had visits to primary care physicians and an emergency department not given PPV All three developed purpura fulminans (two with significant amputations, one with menigitis and renal failure, one death)
30 30 Amsden said the jury's verdict would send a message to the hospital that it is focusing on the wrong areas for cost savings. Jordan's last day at the hospital cost $18,000 - the vaccine would have cost $25.
31 31 Pneumonia Current Surveillance Take home High rates are achievable! National National Benchmark* Percent Influenza PPV
32 32 Where Should We Vaccinate? Anywhere that we find chronically ill or elderly patients!
33 33 Systems-based Strategies Institutional Vaccination Strategies to improve vaccination rates Organizational change Provider reminders Patient financial incentives Provider financial incentives Patient reminders Provider education Patient education Assessment and feedback RAND. Evidence Report and Evidence-based Recommendations: Interventions that increase utilization of Medicarefunded Preventive Services for Persons Age 65 and Older. US Dept of Health and Human Services. Health Care Financing Administration. Contract No September 30, Task Force on Community Preventive Services. Guide to Community Preventive Services. Am J Prev Med. 2000;18(1S):S
34 34 Standing Orders Programs Standing orders programs authorize nurses or pharmacists to administer vaccinations according to an institution- or physicianapproved protocol without a physician s examination
35 35 Standing Orders are Among the Most Effective Strategies Non-physicians offer and administer vaccinations without direct doctor involvement at the time of the visit Established through approved policies & protocols Locations: clinics, hospitals & nursing homes
36 36 STANDING ORDERS FOR INJECTABLE INFLUENZA VACCINATION* FOR PATIENTS NOT PREVIOUSLY IMMUNIZED Effective Annually: October 1st through March 31st (Influenza Vaccine Standing Order Policy & Procedure with Medical Director signature can be found in administration) PATIENT INFORMATION Facility Name: Patient Name: Medical Record #: Patient Assessed by: Date: / / CRITERIA FOR WHICH INFLUENZA VACCINE IS STRONLY ENCOURAGED: All children aged 6 23 months All persons ages 2 49** with Chronic Cardiac Disease, Chronic Pulmonary Disease (including asthma), Diabetes, Renal Failure, Blood Disorders, or Immunosuppression All persons age 50 and older Healthcare workers or Caretakers of high-risk patients Children or teenagers receiving long term aspirin therapy Residents of nursing homes or chronic care facilities All pregnant women If patient meets any of the above criteria but is uncertain about prior vaccination status, or history is unreliable - vaccination recommended. CONTRAINDICATIONS Patient was previously immunized this flu season? Yes or No Patient has had a severe reaction to vaccine? Yes or No Patient has serious allergic reaction to eggs? Yes or No Patient currently has an acute febrile illness? Yes or No Patient has a history of Guillain-Barre Syndrome? Yes or No Physician order not to give vaccine? Yes or No If Yes is answered for ANY question regarding contraindications, STOP ASSESSMENT HERE AND DO NOT GIVE VACCINE VACCINE ADMINISTRATION If vaccine is indicated, and there are no contraindications, then ADMINISTER 0.5 ml Influenza Vaccine IM in deltoid or triceps of dominant arm Observe patient for 15 minutes after injection for possible reaction No adverse drug reaction (ADR) noted after 15 minutes ADR noted - description and treatment: Colorado Clinical Guidelines Collaboration (CCGC) Coordinated in part with CFMC Date of vaccine administration: / / Time of vaccine administration: Site: Route: Manufacturer: Lot #: Vaccine administered by: FLU SHOT INDICATED BUT NOT GIVEN BECAUSE: *Intranasal (live) vaccine is not appropriate for standing orders **For dosages for persons < age 9, consult ACIP for dosing recommendations References: ACIP. Prevention and Control of Influenza. MMWR, 2001, Vol. 50, No. RR-4 ACIP. Use of Standing Orders Programs to Increase Adult Vaccination Rate. MMWR 2000, Vol. 49, No. RR-1 CDC:
37 37 Comparison of Florida PPV Rates* to Vaccination Process * Hospital-submitted data in CMS Warehouse Courtesy FMQAI.
38 38 Institutional Vaccination Conditions of Participation Federal Register, Vol. 67, No. 191 (October 2, 2002) All orders for drugs and biologicals must be in writing and signed by the practitioner or practitioners responsible for the care of the patient as specified under (c) with the exception of influenza and pneumococcal polysaccharide vaccines, which may be administered per physician-approved facility policy after an assessment for contraindications. Includes similar provisions for nursing homes and home health agencies
39 39 Opportunities for Cross-setting Initiatives Hospitals and home health agencies Nursing homes and home health agencies Mass vaccinators
40 40 Annual influenza vaccination is recommended for all persons who work in any medical care facility or provide care in any setting to persons at increased risk of influenza or complications of influenza.
41 41 Deaths Due to Vaccine Preventable Diseases - US, Disease* Influenza Pneumococcal Hepatitis A Hepatitis B Measles Mumps Rubella Pertussis Tetanus Cases (millions) (millions) 282, ,644 60,189 24, , Deaths (all ages) ~ 510,000 ~ 120, VPD = vaccine preventable diseases. MMWR 2001; 48 (RR-53); Thompson et al. JAMA 2003; 289: 179; Feikin DR, et al. Am J Public Health 2000; 90: ~ 630k (90% in elderly) 11k (reported cases though the actual number is likely 5-10 times higher)
42 42 Poland GA. Clin Infect Dis. 2002;35:
43 43 Summary Vaccination rates for our most vulnerable are unacceptably low Vaccination in these settings is effective! Systems-based interventions are the best way to improve vaccination rates
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