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1 _#! # ct U/.../ H Oj'>14'.,- 1.#O/l- ~5o3 ~3 naprnna : H<l>OPMAUW! 3A H3ffiJIHEHHETO HA J:IOrQBOP 3A OoWECTBEHA nop1,ljka (aepc1«4) ~ AO II '- ArEHljl,151 no 0 6ll(ECTBEH1t1 n OPb4 Klt CocjJ1.1~, yn. nere 4 cj)akc: rop@aop.bg, e-rop@aop.bg HHTepHeT aapec: HH<l>OPMAUIUI 3A H31TbJIHEHHETO HA,n:orOBOP 3A OEI.IJ:ECTBEHA IIOPbqKA )],EJIOBO)],HA HH<l>OPMAI(IUI j(ejiobo,[iha uu<f>opmaquh ITapnu::ia Ha Bb3J10)K11Ten51: IToneneH11e : ----,-- I13X0}l5llll HOMep: _1.~1-_6~'=1 OT nata i 'i KoMeHTap Ha Bb3JIO)Kl1Ten51: PA3)],EJI I: B'b3JIO)KHTEJI (glno '-!Jl. 7, T. 1-4 OT 30IT (KJ1aC11'-leCKl1) D no '-!JI. 7, T. 5 11n11 6 OT 30IT ( cektopeh) 1.1) HauMeHoBauue u anpec Ocp11u11anHo Ha11MeH0BaH11e v1hctm TYT no MMKp0 6MOJ10I' MR,,CTe (j;)a H AHr e11 0 B" Anpec yn. AKa.r:i;. reoprx 60HL!eB 1 6JI. N! 26 rpan ITomeHcK11 Kon I JJ:bp)l(aBa Coqix,:r 'bnrapx,q 3a KOHTaKTl1 TenecpoH v1hctmtyt n o MMKp06MOJIOI'MH ; ,,CTe(j;)aH AHI'eJ10B" J111ue 3a KOHTaKT,IJ;OLI,. MaprapxTa KaM6ypo Ba,,IJ;OLI,. EneKTpOHHa noma I1HTepHeT anpec/ 11 ( Kora To e np11j10)l(l1mo) A Apec Ha Bb3J10)l(11Ten51 : http : //www. microbio.bas.bg/. AHaCTac f1alll0b <l>akc Anpec Ha npocp11na Ha Kyny Ba'-!a: http : //www. microbio.bas. bg/imb%20w e b%20page /microbio / ZOP20l5 % 20. html. 1.2) Bun Ha Bb3JIO'.lKUTeJIH H OCHOBHa n euuoct/u: (nonojiba ce OT Sb3JIO)KHTeJI11 no '-!JI. 7, T. 1-4 OT 30IT) O M11H11cTepcrno 11JI11 npyr Abp)l(aBeH oprah, BKJII0'-111TeJ1HO TeXHl1 per110haj1hl1 I1J111 MeCTHl1 nonpa3nejieh1151 O Hau110HanHa arehu1151/cjiy)k6a O Per110HaneH 11n11 MecTeH oprah O PernoHanHa 11n11 MeCTHa arehui151/cny)l(6a 0 06mecrneH11 yceyrn 0 0T6paHa D 06mecrneH pen 11 c11ryphoct O OKonHa cpena 0 I1KoHoM11'-!eCKa 11 cp11hahc0ba.n.ei1hoct D 3ApaBeona3Batte (gl I1y6n11'-!HOnpaBtta opratt11jau1151 D HacTatt51BaHe/)l(11J111UlHO crpo11tencrno 11 0 EBponei1cKa 11ttcT11Tyu1151/areHUI151 11n11 MeCTa 3a OT}l11X 11 Kynzypa Me)l(,ll.yHapo.n.Ha opratt11jau1151 D Cou11antta 3aKp11na Yl-ITl : 94bc0e53 -cd0e J ae,0767a73 J 529f

2 n aprn.aa: MH<l>OPMAl.(J,UI 3A H3ff1JIHEI-IJ,IETO HA AOrQBOP 3A OE!lIECTBEHA nopl,'-!ka (sepcu 4) 0.D:pyro (Mo1u1, YTO'rneTe): 1.3) OcnoBna )J,eiinoCT/u na Bb3JIOJKHTem1, CBbp3aea/n c: (nomjiba ce OT Bb3J10)1(HTeJ1 no l!jl. 7, T.5 HJIH 6 OT 30IT) 0ITpoH3BO,llCTBo, npettoc 11 pa3npe.uenett11e Ha nphpo,lleh ra3 H TOOJIHHHa ettepnu, O EneKTpHt.JecKa ettepnu, D Tbpcette, npoyt.jbatte HJIH,llo611B Ha np11po,lleh ra3 11n11 tteqn 0Tbpcette, npoyl!batte ,no611B tta Bbf"JIHIUa HJIH,llpyrn TBbp,llH rop11ba 0Bo,lla OOT,llHX, Kynrypa 11 pen11rm1 006pa30Batt11e 181.D:pyro (MOJI51, YTOt.JHeTe): ttayt.jtta,!].ehhoct OrrowettcKH ycjiyrn O )Kene3onbTHH ycnyrn Orpa,llCKH )l{ejie300bthh, TpaMBaHHH, Tponei16yctt11 HJIH abrn6yctt11 ycnyrn 0flpHCTaHHIUHI1,lleHHOCTH O JieTHIUHH,lletl.ttocrn PA3,IJ;EJI II: IIPOI(E,IJ;YPA, IIPE,IJ;XO)l(,Il;AlnA CKJIJOqBAHETO HA,n;oroBOPA 11.1) Bui. ua npou:eayparn 1810TKpttrn npoue.!lypa OOrpatt11l!etta npoue.uypa 0 CbcTe3aTenett.rrnanor D.D:oroBap51He c o65ibjiett11e D.D:oroBap51He 6e3 o65ibj1ett11e 11.2) 06eKT ua nopb<jkata 0CTpOHTeJ1CTBO ~,[J:OCTaBKH 11.3) Ilpou:eAyparn e OTKpnrn c pemenue No: 5 5 OT 13/0l /2016,ll,U/MM/rrrr 0 Ycnyrn 11.4) YnnKaJieu N2 ua nopb<jkata B PerucTbpa ua o6mectbenute nopb'ikh I (nnnnn-yyyy-xxxx) II.5) Onucauue ua npei.meta ua nopb11kata UenTa Ha HacToRmaTa o6mectbeha nopbqka e )].ace M36epaT M3CTbflHMTenM, KOMTO )].a,!j.octabrt MaTepManM, XMMMKanM M KOHCyMaTMBM 3a HayqHo- M3cne)].OBaTencKM npoektm B M3nbnHeHMe Ha ~orobop N! ~03-100/ r. 3a M3nbnHeHMe Ha npoekt : "Pa3Hoo6pa3Me M 6MoTexHonorw-i:eH notehu:man Ha Archaea ot 6bnrapCKM ropemm M3BOpM " M ~orobop N! ~ / r. 3a M3nbnHeHMe Ha npoekt: AHanM3 Ha ahtmtrflobmr peneptoap C nomomta Ha pau:mohanho no)].6pahm nentm,!j.hm MaCMBM ", qlmhahcmpahm no MRpKa "TipoeKTM 3a Me~,!J.YMHCTMTYU:MOHanHO CbTPYJlHMqecTB0 11 OT EBpone~CKOTO MKOHOMW.J:eCKO npoctpahctbo , nporpama BG09 " <POH)]. 3a CTMneH)].MM Ha EMTI". C M3CTbnHeHMeTO Ha npoekt "Pa3H006pa3Me M 6MoTexHonorMqeH notehu:man Ha Archaea OT 6bnrapCKM ropemm M3BOpM " ce u:enm ono3habahe apxeanhoto pa3hoo6pa3me B 6bnrapcKM ropemm M3BOpM M M30nMpaHeTO Ha HOBM ekctpemoq)mflhm apxem, npe)].naramm HOBM 6MOTexHonorMqHM Bb3MO~HOCTM. C MOneKynRpHo-6MonorMqeH no)].xo)]. me ce xapaktepm3mpa CTPYKTypaTa Ha apxeanhmte Cbo6mecTBa, me ce onpe,!].enrt,!j.ommhahthmte M MM HOpHO npe)].ctabehm TaKCOHM. me ce M30flMpaT KynTMBMpyeMM apxem M ~e ce ontmmm3mpat ycnobmrta 3a TRXHOTO KYflTMBMpaHe. Cpe)]. M30naTMT e me ce TbpCRT HOBM 6MonorMqHM BM,!J.OBe. me ce cekbehmpat M ahanm3mpat rehommte Ha M36paHM M30naTM C u:en )].ace yctaho BM npmcbctbmeto Ha rehm, KO,!].MpamM HOBM eh3mmm M nonm3axapm,!].m. qpe3 CKpMHMHr me 6b)].aT no)].6pahm nepcnektmbhm npo,!j.yu: ehtm Ha Te3M 6MOTeXHOnorMqHO u:ehhm semectba. UenTa Ha npoekt,,ahanm3 Ha ahtmtrflobmr peneptoap C nomomta Ha Ylffi: 94bc0e53 -cd0e lae-0767a731529f

3 napnrna: o 1482 HH<!>OPMAUW! 3A H3ITT,J1HEHJ1ETO HA LlOrGBOP 3A 06WECTBEHA nop1,l{j(a (eepc11, 4) pauhohanho non6pahh nenthllhh MaCHBH " e na ce Cb3nane HOBa nnat~opma 3a llharhocthka, OCHOBaHa Ha ahanh3 Ha peneptoapa OT ahthtena (HnH HrOMa) y OTneneH HHllHBHll c DOMOmTa Ha 6H6nHOTeKa OT HM06HnH3HpaHH nenthllh (microarray). AHTHTenaTa pa3n03habat cneum~mqho qact OT MOn ekynata Ha CbOTBeTeH ahtmreh HapeYeHa enhton. TienTHllHTe, KaTO 4aCTH OT npotehhobh MOneKynH, npenctabnrbat ITOTeHUHanHH enhtonh, HO no - YeCTO ce pa3n03habat KpbCTOCaHO OT ahthtena C npyra cneuh~h4hoct ( KopeKTHO e na ce rosoph 3a nonhcneuh~h4hoct). Torasa Te3H nenthllh ce HapHYaT MHMOTODH. Tipenno~eHHTe nenthllhh 6H6nHOTeKH, B T03H CMHCbn, ca 6H6nHOTeKH OT MHMOTOnH, KOMnneMeHTapHH H ODTHManHO npenctabrmh pa3h006pa3heto OT cneuh~h4hocth Ha ahthtena B peneptoapa. CnenosaTenHo, TOBa me 6bne Ha6op OT rrenthllh (nx103) BbB ~opmat Ha microarray, KOMTO e~ekthbho OT4HTa llhhamhkata Ha CbBKYDHOCTTa OT ahthtena nph nhnca Ha HH~OpMaUHR 3a nphponata Ha ahthrehhte npobokhpanh npomehhte. PenepToapbT Ha Mrr H MrM ahthtenata me 6blle H3CnenBaH HHllHBHnyanHO H Ha nonynauhohho HHBO. 3a o6o6mehata KapTHHa me H3non3BaMe HMyHorno6ynHHOBH npenapath 3a BeH03HO nphno~ehh, KOHTO ca Cb3llaneHH Ha 6a3aTa Ha c6op OT cepymh Ha Han llohoph. Tiono6eH TeCT Ha CHCTeMHO HHBO HMa 3Ha4HTeneH notehuhan 3a nphno~ehhe nph nharhocthka Ha abtohmyhhh, OHKOnorH4HH, HH~eKUH03HH H CHCTeMHM Bb3nanMTenHM 3a6onRBaHMR. TipenHWHM H3CnensaHHR noph C HeOnTHMM3HpaHH (cnyyamhh) 6H6nHoTeKH noncka3bat H3HeHansam KanauHTeT 3a enhobpemehha llharhoctmka He camo Ha pa3nm4hh 3a6onRBaHMR, HOH, HanpHMep, pa3nm4hh CTallHH H ~OpMH Ha TYMOpH. Tosa e Bb3MO~HO 3amoTO BponeHHRT H ananthbhhrt HMYHHTeT 3aenHo CbCTaBnRBaT ectectbeh ceh30p 3a npomehh B,,MoneKynHMR rrem3a~" Ha oprahh3ma, a ahthtrnobhrt peneptoap e CMrHan Ha H3XOlla OT Ta3M CMCTeMa, KOMTO TpR6Ba na 6bne OT4eTeH C HHCTpyMeHTHTe Ha CMCTeMHaTa 6MonorHR. ~emhocthte no H3DbnHeHHe Ha HaCTORmaTa o6mectbeha nopb4ka BKnID4BaT lloctabka Ha XHMHKanM, peakthbh M KOHCyMaTMBH, KOMTO na Cb3llanaT Bb3MO~HOCTM 3a npobe~nahe Ha Ka4eCTBeHa Hay4HO - H3cnenosaTencKa H pa3bomha nemhoct B MHCTHTYT no MHKp06HonorHR,,CTe~aH AHrenos" nph BAH. XHMHKanMTe, peakthbhte M KOHCyMaTHBMTe, KOHTO me 6bllaT lloctabehh ca CBbp3aHM nprko C nemhoctta Ha MHCHTMTYT no MHKp06MonorHR,,CTe~aH AHrenos". PA3)];EJI Ill: YCJIOBIDI HA i];orobopa III.1) HoMep Ha norobopa: 14 OT 04/05/2016 M/MM/rrrr III.2) HacTOHIUHHT /1,0roBop e CKmoqeu cjie/1, 18)llpoue;:zypa 3a Bb3JTaraHe Ha o6mecrneha nopblika D PaMKOBO cnopa.3ymem1e 0,nHHal\rn'rna CHCTeMa 3a noctabkj1 D CHcTeMa 3a npenbap11tej1eh non6op 111.3) li3nbjihhteji no /1,0roBopa OcpttUHaJTHO HaHMeHoBaHHe H EI1K (Kon no ByJTcTaT) AKsaxHM A~, EMK Ati,pec 6yn. Tipo~. U:B etah J1a3apos N! 83 rpan llomehckh KOL{ I,nbp)KaBa CO~HR 1582 EbnrapHR EJTeKTpOHHa noma TeJTecpoH CDaKC YHn: 94bc0e53 -cd0e ae-0767a731529f

4 naprnna: H<l>OPMAIDU! 3A H3ff1JIHEHHETO HA norosop 3A OSmECTBEHA nopl,lll(a (aepc11, 4) I1HTepHeT Mpec (URL): I 111.4) Ilpu H3DbJIHeHUeTO yqactbat DO.[l;H3DbJIHHTeJIU )];a D He 181 O<J>uunaJiuo uanmenobauue ua )l;eiiuoct, H3DbJIHHBaua OT )l;hji ua DOllH3DbJIHUTeJIH IlOJJ:H3IlbJIHHTeJISJ yqactne na Il01lH3IlbJIHHTe JIH (% OT norobopa) 111.5) IlpenMeT ua norobopa,i\octabka Ha XJ.1 MJ.1K a.dj.1 J.1 peaktj.1bj.1 3a MO.n eky.nrph0-6j.10.norj.1yha paoota ) CpoK ua H3DbJIHenue CpoK Ha H3ITbJ1Hem1e B Meceu11: l1j hh ( OT CKJ1IOqBaHe Ha.uoroBopa) J1J111 HaqanHa.11.aTa.DJJ/MM/rrrr KpatiHa.n:arn 30/09/2016.DJJ/MM/rrrr 111.7) CToiiuocT, nocoqeua B.a;oroBopa (B a;u<j>pu): CTOHHOCT: Banyrn: BGN PaJMeHeH Kypc KbM BGN: 111.8) )l;orobopbt e <J>uuaucupau c ebponeiicku cpenctba <P11HaHc11paHeTO e 100 % OT CTOHHOCTia Ha AOfOBO pa. PA3,l(EJI IV: H3IIbJIHEHHE HA,l(OrOBOPA 181.uoroBOpbT e J13ITbJ1HeH O.uoroBopbT e npe.n:cpoyho npekpateh IV.I) )];am ua npukmoqbaue/npekpanrnaue: 29/09/20 16 MiMM/rrrr IV.2) Ilpuquuu 3a npekpathbaue ua norobopa (KoraTo e npujimknmo) 6e3Ll[(C c.[l[(c Crni1HocT Ha.lJ:)l;C (B %) 181 D rrp11 (KpaTKO on11cahi1e Ha o6ct051tej1ctbata, KOHTO o6ycnab5it npekpaubaheto) IV.3) )l;orobopbt e H3MeHHu/.a;oobJIBau )];a D He 181 IlpoMeueuo Ilpenu npomhhata CJie.a; npomhhata IlpaBHO OCHOBauue ycjiobhe OT.uoroBopa 3a npomhhata IV.4) )l;orobopbt e H3DbJiueu B cpok.d:orobopbt e 113ITbJ1HeH CbC 3a6aBa OT Meceu( a) D.HI1 OT Kpai1:Hl15! cpok Ha 113rr1,11HeH11e Ha.11.oroBopa CTp11YJ1HI1 3a 3a6aBaTa (KoraTO e np11j10)ki1mo ): (KpaTKO orr11cah11e Ha rrp11q11 H11Te 3a 3a6aBarn) IV.5) )l;orobopbt e H3DbJiueu B DbJieu o6em J13n1,11Hem1eTO e % OT rrpe,n:meta Ha.uoroBopa (rrp11 qact11qho 113n1,11HeH11e). YHTI: 94bc0e53-cd0e lae-0767a731529f

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