Vol. Eleven No. One. January, 1978 FLUORIDE OFFICIAL QUARTERLY JOURNAL. I NTERNATioNAL

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1 January, 1978 Vol. Eleven No. One FLUORIDE OFFICIAL QUARTERLY JOURNAL OF I NTERNATioNAL

2 OFFICERS Prridant Via Prrident s.cond Via Prrident Prof. G. W. Miller, Ph. D. H. M. Sinelair, M. 0.. D. Sc Prof. S. S. Jolly, M.D. Utah State Univmity Lrboratory of Human Nutrition Mdial Coll.rr Logan, Utah Oxon, England Potida, India Surotary G. L. Waldbott, M.D. Warren, Michigan Trmsurar P. E. Zanfngna, M.D. Lawranca. Mruchumtts Prof. G. Fradi. M.D. Imtituta of Occupational Mdicine Unimity of Palrmo, Italy Prof. G. Halbwachs, Ph. D. Instituta of Botany Vienna, Austria Prof. Dr. G. Rosanbo~g.r Votrinary Univaoity Hannover, Gormany ADVISORY BOARD J. V. Muhdd, M. D., Ph. D. Raoarch Institute for Organic Synthesis Pardubia, CSSR Prof. J. 6. Patrick, Ph. D. Mary Baldwin c0ll.o. Staunton, Virginia Prof. F. Pirut, M.D. Rhem, Francs A. H. Siddqui, M.D. Coon Rapids. Minnasom Prof. Rod Truhaut, Ph. D. Facult; 0. Pharrmcia Univorsiti do Paris, France Prof. A. W. Bu~tahler, Ph. D. Univmity ~. of I I I KI Lmronca. KaM MUDr. G. Baluova CSc. Research Institute for Hygiene Bratislava, Czochodovakia EDITORIAL BOARD Prof. G. Neil Jenkins The Dental School, Univ. of Newcastle Upon Tyne, England Prof. Fderick W Wmo, D.V.M., Ph.C Kansas State University Manhattan, Kansas Dr. Ernest Bovay, Director Jmy Krechniak, Ph. D. Federal Agric Research Station Akadmia MO~WM, Liebefdd Bern, Switzerland Gdafisk, Poland Prof. Albm Schnt, Ph. 0. Tamplo Univaoity Phildalphia, Pa. J. Frankc. M.D. John R. McLaren, M.D. Carlo Manaoni di S. Stefano. M. D. Martin Luther Universtit RoM Winship Memorial Clinic Insdtuta-of Human Physiology HaIIe/Sula, DDR Emory University Atlanta, Georgia University of Naples, Italy Prof. S. P. S. Taotia, M. D. 2.L OIkowJd M.D.. 8cD. H. Hanhijarvi, D. D. S. Department of Human Yoc(ta ROIIIOMI Pdmmta Korpilahti, Finland Metabolism R.umhc.ntr Medial Cdloga K.A.V.R. Krihnamachari, M.D. tnory u*=m University of Moorut, India. National Institute of Nutrition Atkna Goo@. Hyderabd, India

3 Vol. Eleven No. One January, 1970 Pages 1-42 Quarterly Reports Issued by THE INTERNATIONAL SOCIETY FOR FLUORIDE RESEARCH Editor 0. L -.M.D. Warren, Michigan CbEditon A.WhI)urglt.hkr,PhD. Lmrence, bnur J. A Yhnouyhn+ Ph. D. Delaware, Ohio EDITORIAL Fluoride in Soil... 1 ORIGINAL ARTICLES Incorporation of a Dietary Fluoride Supplement into Bones and Developing Teeth of the Pig - by R. L. Speirs, London, England... 4 Aconitate Hydratase Activity and Citrate Content of Heart and Kidney in Fluoride Affected Cows - by G. W. Miller, M. N. Egyed and J. L. Shupe, Logan, Utah. Interactions by Fluoride with a Mineral Soil Containing Mite and Alterations of Maize Plants Grown in this Soil -by H. Hani, Liebefeld-Bern, Switzerland... Long-Term Effects of Fluoride Administration - An Experimental Study ii) Effect on Serum Proteins - by R. Kaur, P. Singh and S. S. Makhni, Patiala, India... Skeletal Changes in Industrial and Endemic Fluorosis -by E. Czerwinski and W. Lankosz, Cracow, Poland... Electromyographic Studies in Endemic Skeletal Fluorosis - by M. Veera Raghava Reddy, D. Raja Reddy, S. B. Ramulu and D. S. Mani, Andhra Pradesh, India... ABSTRACTS Mechanical Properties and Density of Bone in a Case of Severe Endemic Fluorosis - by F. G. Evans and J. L. Wood, Ann Arbor, Michigan... Cytogenetic Investigations on Leucocytes of Cattle Intoxicated with Fluoride - by A. Leonard, G. H. Deknudt, G. Decat and E. D. Leonard, Brussels, Belgium

4 Distribution of Soil Fluorides Near an Airborne Fluoride Source - by J. R. McClenahen, Wooster, Ohio... Fluorides - Use with Caution - by L. E. Church, Washington, D. C Fluoride Kinetics after Enflurane Anesthesia in Healthy and Anephric Patients and in Patients with Poor Renal Function - by R. Carter, M. Heerdt and S. Acchiardo, Memphis, Tennessee The Effect of Magnesium and Fluoride on Nephrocalcinosis and Aortic Calcification in Rats Given High Sucrose Diets with Added Phosphates - by H. Luoma, T. Nuuja, Y. Collan and P. Nummikoski, Helsinki, Finland FLUORIDE is published quuterly by THE INTERNATIONAL SOCIETY FOR FLUORIDE RESEARCH, INC.. SUBSCRIPTION RATES Price per annum in advance including postage $ Single copies $7.00. MANUSCRIPTS for publication should be submitted in Englkh, doublewaced with g.mour mwgim. Refermces should be arranged according to the ordar in which thw are cited in the text, and written as follows: Author, title, joumol, volume, psgrr and year. Each paper must contain a summary of not more than 12 lines. FLUORIDE is listed in Current Contents Agricultural Food and Veterinary Sciences x Society's office, P.O. Box 692, Warren, Michigan Capyright by Intorrucional -for Fluorid. Rerunh. All Rid'tha Ro.rvd. Noither thir Wort nor am part my k roprobud or uammimd in my form or by any mum. olcuonic of mechanical. induding photocopying, microfilming, and rocording, or by my information storqo and ntriwal WUm. wibut pumiuion in miting from tho publisher.

F- Uptake in Bones, Teeth 5 year at school too late to begin ingestion of fluoride for protection of the most caries -susceptible teeth, ffrst permanent molars?

9 F- Uptake in Bones, Teeth 5 year at school too late to begin ingestion of fluoride for protection of the most caries -susceptible teeth, ffrst permanent molars? Can fluoride treatment be restricted to 'certain short periods?'. Until-recently no direct evidence provided answers to these questions. Some clinical observations made over 30 years ago in this country (1) and more recently in Holland (2) suggest that just before and at the time of eruption is the critical period but this has not been tested experimentally. Objectives To study such a problem it is necessary to have a model as it is impracticable to investigate this in children. Our earlier work (3) showed that the dentition of the young domestic pig provides a spectrum of stages in enamel formation. There is a close similarity in the profile of tooth development in a 7 month old pig and a 6 year old child (Fig. 1). The aim of this study was to supplement the diet of pigs with fluoride or a short period and then to relate the amount of fluoride taken up in the enamel of each unerupted tooth during this period to the particular stage reached in mineralization. By including animals aged 3 and 9 months it was considered that both early and late stages of enamel formation and maturation would be ccvered. Bone and dentine were also analyzed. Since bone is moremetabolically reactive than enamel, it can serve as a guide to the availability of ingested fluoride. It was not feasible to carry out balance studies on food, urine, and feces. Figure la Schematic Representation of the Lower Dentitions of a Pig about 7-Months Old '3 I The permanent teeth are labelled. Only the first molar is erupted. FLU 0 RIDE

Vol. Six No. Four. October, 1973 FLUORIDE OFFICIAL QUARTERLY JOURNAL

Vol. Six No. Four. October, 1973 FLUORIDE OFFICIAL QUARTERLY JOURNAL October, 1973 Vol. Six No. Four FLUORIDE OFFICIAL QUARTERLY JOURNAL OF President Prof. A.W. Burgstahler University of Kansas Lawrence, Kansas Vice-President Prof. Aly H. Mohamed University of Missouri