Extension Study 2, Self Reported, Non-Adjudicated Outcomes for MRC Participants

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1 Extension Study 2, Self Reported, on-adjudicated Outcomes for s File ame A self report is only counted if the first report of that outcome occurred after the start of the extension 2 phase of the study. ID WHI Common ID Col#1 F33AGHOSP F33 Hospitalized Angina Col#2 0 o 20, Yes 1, F33AGHOSPDY Days enrollment to F33 Hospitalized Angina Col#3 1,350 20, , F33COPD F33 COPD Col#4 COPD, emphysema, or chronic bronchitis 0 o 19, Yes 2, Usage otes: Only collected during the WHI Extension Study 2. F33COPDDY Days enrollment to F33 COPD Col#5 2,431 19, , F33AFIBHSP F33 Hospitalized Atrial Fibrillation Col#6 0 o 20, Yes 1, Usage otes: Only collected during the WHI Extension Study 2 F33AFIBHSPDY Days enrollment to F33 Hospitalized Atrial Fibrillation Col#7 1,891 20, , F33AFIBOP F33 Outpatient Atrial Fibrillation Col#8 0 o 21, Yes 1, F33AFIBOPDY Days enrollment to F33 Outpatient Atrial Fibrillation Col#9 1,122 21, , F33MSC on-melanoma Skin Cancer Col#10 Page 1 of 7

2 Extension Study 2, Self Reported, on-adjudicated Outcomes for s File ame 0 o 21, Yes F33MSCDY Days enrollment to F33 on-melanoma Skin Cancer Col# , , F33BKULEG F33 Broken Upper Leg Col#12 0 o 22, Yes F33BKULEGDY Days enrollment to F33 Broken Upper Leg Col# , , F33BKPELV F33 Broken Pelvis Col#14 0 o 21, Yes F33BKPELVDY Days enrollment to F33 Broken Pelvis Col# , , F33BKKEE F33 Broken Knee Col#16 0 o 21, Yes F33BKKEEDY Days enrollment to F33 Broken Knee Col# , , F33BKSPIE F33 Broken Spine Col#18 0 o 21, Yes F33BKSPIEDY Days enrollment to F33 Broken Spine Col# , , Page 2 of 7

3 Extension Study 2, Self Reported, on-adjudicated Outcomes for s File ame F33BKUARM F33 Broken Upper Arm Col#20 0 o 21, Yes F33BKUARMDY Days enrollment to F33 Broken Upper Arm Col# , , F33BKLARM F33 Broken Lower Arm Col#22 0 o 21, Yes F33BKLARMDY Days enrollment to F33 Broken Lower Arm Col# , , F33BKHAD F33 Broken Hand Col#24 0 o 22, Yes F33BKHADDY Days enrollment to F33 Broken Hand Col# , , F33BKLLEG F33 Broken Lower Leg Col#26 0 o 21, Yes F33BKLLEGDY Days enrollment to F33 Broken Lower Leg Col# , , F33BKFOOT F33 Broken Foot Col#28 0 o 21, Yes F33BKFOOTDY Days enrollment to F33 Broken Foot Col# , , F33BKTAILB F33 Broken Tailbone Col#30 Page 3 of 7

4 Extension Study 2, Self Reported, on-adjudicated Outcomes for s File ame 0 o 22, Yes F33BKTAILBDY Days enrollment to F33 Broken Tailbone Col# , , F33BKELBOW F33 Broken Elbow Col#32 0 o 22, Yes F33BKELBOWDY Days enrollment to F33 Broken Elbow Col# , , F33BKOTHBX2 F33 Broken Other Bone Col#34 Broken other bone, Extension 2 definition. 0 o 20, Yes 1, Usage otes: This variable does not map to the Broken Other Bone (F33BKOTHB) variable collected prior to Extension Study 2, as the form question changed. F33BKOTHBX2DY Days enrollment to F33 Broken Other Bone Col#35 1,431 20, , F33AYFXOHIP F33 Any on-hip Fracture Col#36 Any fracture except hip (includes other bone). 0 o 17, Yes 4, Usage otes: 1 if any of the non hip fractures were first reported in WHI extension study 2 F33AYFXOHIPD Y Days enrollment to F33 Any on-hip Fracture Col#37 4,610 17, , F33HYST F33 Hysterectomy Ever Col#38 0 o 21, Yes Page 4 of 7

5 Extension Study 2, Self Reported, on-adjudicated Outcomes for s File ame F33HYSTDY Days enrollment to F33 Hysterectomy Ever Col# , , F33OSTEOAR F33 Osteoarthritis Col#40 0 o 18, Yes 4, Usage otes: ot collected on all versions of F33. F33OSTEOARDY Days enrollment to F33 Osteoarthritis Col#41 4,214 18, , F33ITPOLYP F33 Intestinal Polyps Col#42 0 o 20, Yes 1, F33ITPOLYPDY Days enrollment to F33 Intestinal Polyps Col#43 1,861 20, , F33LUPUS F33 Lupus Col#44 0 o 22, Yes F33LUPUSDY Days enrollment to F33 Lupus Col# , , F33PILLSHYP F33 Pills for Hypertension Col#46 0 o 20, Yes 2, F33PILLSHYPDY Days enrollment to F33 Pills For Hypertension Col#47 2,068 20, , Page 5 of 7

6 Extension Study 2, Self Reported, on-adjudicated Outcomes for s File ame F33DIABTX F33 Diabetes Treated Col#48 0 o 20, Yes 1, Usage otes: Pills or insulin shots. F33DIABTXDY Days enrollment to F33 Diabetes Treated Col#49 1,846 20, , F33DIABISULI F33 Diabetes Insulin Col#50 0 o 21, Yes F33DIABISULIDY Days enrollment to F33 Diabetes Insulin Col# , , F33DIABPILLS F33 Diabetes Pills Col#52 0 o 20, Yes 1, F33DIABPILLSDY Days enrollment to F33 Diabetes Pills Col#53 1,792 20, , F33DIABDIEX F33 Diabetes Diet and/or Exercise Col#54 0 o 19, Yes 2, Usage otes: F33DIABDIEXDY Days enrollment to Diabetes Diet and/or Exercise Col#55 2,721 19, , F33PARKISOS F33 Parkinsons Col#56 0 o 22, Yes Usage otes: Page 6 of 7

7 Extension Study 2, Self Reported, on-adjudicated Outcomes for s File ame F33PARKISOSDY Days enrollment to F33 Parkinsons Col# , , F33ALZHEIMERS F33 Alzheimers Col#58 0 o 19, Yes 2, Usage otes: F33ALZHEIMERSDY Days enrollment to F33 Alzheimers Col#59 2,376 19, , F33MACDEGE F33 Macular Degeneration Col#60 0 o 19, Yes 2, Usage otes: F33MACDEGEDY Days enrollment to F33 Macular Degeneration Col#61 2,687 19, , LAST33DY Days enrollment to last form 33/33D Col#62 Days from enrollment to last contact for outcomes information , Usage otes: LAST33DY is calculated as the days from enrollment to the latest Form 33 during Extension Study 2. Because of the adjudication process, it is possible that there are some adjudicated events with days to event beyond LAST33DY. LAST33DY may be missing if the ppt had no form 33s entered for extension 2. F33HOSPX2 F33 Hospitalized During Extension Study 2 Col#63 0 o 8, Yes 13, F33HOSPTIMESX2 F33 umber of Hospitalizations During Extension Study 2 Col#64 0 one 8, One 5, Two 3, Three or more 4, Page 7 of 7

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