Endocrine Therapy-Induced Alopecia (EIA) Mario E Lacouture MD Member, Memorial Hospital Director, Oncodermatology Program New York, NY
|
|
- Donna Griffith
- 5 years ago
- Views:
Transcription
1 Endocrine Therapy-Induced Alopecia (EIA) Mario E Lacouture MD Member, Memorial Hospital Director, Oncodermatology Program New York, NY
2 Disclosures Research funding Berg, BMS, Genentech/Roche, RJR Fund, Galderma, Paxman,Novartis Consulting/Advisory Legacy, Novartis, Janssen, BMS, Genentech/Roche, Galderma, Debio, Pfizer, Helsinn, Silk Therapeutics, Foamix, Boehringer Ingelheim, Medische Voet
3 Endocrine Therapy in Breast Cancer Ali and Coombes, Nat Rev Cancer 2002
4 Puglisi et al, Ann Intern Med 2001; Rossi et al, Ann Onc 2013
5 Yip et al, Br J Dermatol 2009, 2012
6 Hormones and Hair-Dangerous Liasions Ohnemus et al, Endocrine Rev 2006; Brough, Int J Womens Derm 2017
7 Endocrine Therapy-Induced Alopecia (EIA) Hairs after AI/ Tamoxifen Saggar et al, Oncologist 2013; Hillman et al, Br J Dermatol 2012; Galliccio et al, Br Cancer Res Treat 2013; Rossi et al, Ann Onc 2013
8 Estrogen (not Testosterone) is Good for Hair Estradiol + Spironolactone Adenuga et al, JAAD 2012
9 Endocrine Therapy-Induced Alopecia (EIA) SERMs, Aromatase inhibitors Meta analysis (n=13,145): 4.4% Survey (n=868): 31.8% Tamoxifen 1 yr Anastrozole 3yrs Saggar et al, Oncologist 2013; Park et al, Ann Dermatol 2014; Galliccio et al, Br Cancer Res Treat 2013; Lindner et al, Br J Dermatol 2012
10 CHANCE: A Prospective, Longitudinal Study of Chemotherapy- Induced Hair, Skin And Nail Changes in Women with Breast Cancer That I will permanently lose my hair from chemotherapy or with hormones? Primary endpoint: Incidence/severity of permanent CIA or HTIA Therapy Init Eval Eval Eval Eval Eval Study end Global alopecia Yr 0 Yr 1 Yr 2 Yr 3 ClinicalTrials.gov Identifier: NCT
11 CHANCE: A Prospective, Longitudinal Study of Chemotherapy- Induced Hair, Skin And Nail Changes in Women with Breast Cancer That I will permanently lose my hair from chemotherapy or with hormones? Primary endpoint: Incidence/severity of permanent CIA or HTIA Therapy Init Eval Eval Eval Eval Eval Study end Yr 0 Yr 1 Yr 2 Yr 3 Hair number/diameter ClinicalTrials.gov Identifier: NCT
12 CHANCE study (Data cutoff December 2017) Alopecia Tamoxifen cohort N=21 (%)* Aromatase inhibitor cohort N= 20 (%) CTCAE v4.03 Baseline Follow-up Baseline Follow-up Grade 0 (no alopecia) 14 (66.7) 6 (28.6) 11 (55) 8 (40) Grade 1 (<50% of hair loss) 7 (33.3) 15 (71.4) 7 (35) 11 (55) Grade 2 (>50% of hair loss) (5) 1 (5) Trichoscopy data Baseline Follow-up Baseline Follow-up Hair shaft N per cm2 199 (36.51) (33.49) (45) (51.9) Hair thickness (microns) 70 (10) 70 (10) 70 (10) 70 (10) Lacouture et al, ASCO Annual Meeting 2018
13 CHANCE study (Data cutoff December 2017) Skin disorders a year after follow-up Tamoxifen cohort N=21 (%) Eyelash alopecia (any grade) 3 (14.3) 2 (10) Eyebrow alopecia (any grade) 2 (9.5) 2 (10) Aromatase inhibitor cohort N= 20 (%) Nail disorders* Tamoxifen cohort N=17 (%) Aromatase inhibitor cohort N= 16 (%) Nail discoloration (Grade 1) 6 (35.3) 7 (43.8) Nail ridging 8 (47) 10 (62.5) Nail loss 0 (0) 0 (0) Paronychia 0 (0) 0 (0) Lacouture et al, ASCO Annual Meeting 2018
14 Time to alopecia development (n=72) Months on therapy * ECDF: empirical cumulative distribution function Freites-Martinez et al, JAMA Dermatol 2018
15 Quality of Life n=52 Hair Shaft Diameter (n=82) Freites-Martinez et al, JAMA Dermatol 2018
16 Post-Chemotherapy Alopecia: pcia or EIAC Baseline characteristics pcia No. (%) (n = 98) EIAC No. (%) (n = 94) P Median age 56.5 (18-83 years) 56 (29-84 years).90 Phenotype Pattern alopecia (Androgenetic alopecia-like pattern) 44 (59) 69 (75).04 Diffuse alopecia 31 (41) 23 (25) Alopecia severity by CTCAE v4.0 Grade 1 46 (61) 80 (87) <.001 Grade 2 29 (39) 12 (13) Eyebrow/eyelashes alopecia 28 (37) 26 (28).25 Trichoscopy characteristics No. (SD) (n = 45) (46) No. (SD) (n = 62) (66) Hair shaft diameter (microns) Hair density (per cm 2 ) 104 (48) 116 (35).14 Mean hair per follicular unit <.001 Freites-Martinez et al (unpublished data)
17 Post-Chemotherapy Alopecia: pcia or EIAC 50 * Normalized Hairdex score (possible range: 0-100) Emotions Self-confidence Functioning Stigmatization Symptoms pcia (n = 41) EIAC (n = 58) pcia Mean EIAC Mean Freites-Martinez et al (unpublished data)
18 Post-Chemotherapy Alopecia: pcia or EIAC pcia EIAC
19 Alopecia Management Minoxidil 2% Finasteride 2.5mg Won et al, Dermatol Ther 2017; Brough, Int J Womens Derm 2017
20 Androgen Inhibition for Alopecia Finasteride 2.5mg 24 weeks Won et al, Dermatol Ther 2018
21 Alopecia Management Algorithm Brough, Int J Womens Derm 2017
22 Tamoxifen, 39 y/o Tamoxifen + Minoxidil Freites-Martinez et al, JAMA Dermatol 2018
23 Anastrozole, 72 y/o Anastrozole + Minoxidil+ Spironolactone Freites-Martinez et al, 2017 et al, JAMA Dermatol 2018
24 ETAL Management-Clinical Outcome Letrozole, 66 y/o Letrozole + Minoxidil Freites-Martinez et al, JAMA Dermatol 2018
25 60% Minoxidil 5% (n=46) 50% 50% 40% 30% 26% 24% 20% 10% 0% No Improvement Moderate Improvement Significant Improvement Freites-Martinez et al, JAMA Dermatol 2018
26 Anastrozole, 72 y/o Anastrozole + Minoxidil+ Spironolactone Follicles: 28 HS diameter (avg): 82 Follicles: 35 HS diameter (avg): 89 Freites-Martinez et al, JAMA Dermatol 2018
27 120 P<0.05 Patients on AI/Tam (n=41) Density (number of hairs) P< Diameter (Microns) Baseline Follow-up Difference Terminal hair density Vellus hair density Hair shaft diameter -20 Freites-Martinez et al, JAMA Dermatol 2018
28 Endocrine Therapy-Induced Alopecia (EIA): Conclusions Endocrine therapies frequently result in alopecia Impact on QoL significant Severity usually is grade 1 (mild) and responds to minoxidil and spironolactone EIA will increase in importance Longer adjuvant therapy and increased survival Decreased incidence of CIA with novel therapies Trials for EIA
29 Thank you
Impact of Cancer Therapies on Hair and Management Strategies
Impact of Cancer Therapies on Hair and Management Strategies Mario E Lacouture MD Member, Memorial Hospital Director, Oncodermatology Program New York, NY Disclosures Research funding Berg, BMS, Genentech/Roche,
More informationImmune-Related Adverse Events: Dermatologic
Immune-Related Adverse Events: Dermatologic Mario E Lacouture, MD Director, Oncodermatology Program Attending, Dermatology Dermatology Service, Department of Medicine lacoutum@mskcc.org Disclosures Research
More informationTips on getting the most from your alopecia pathology reports. D irector, H a ir C linic, Boston Medical C e n ter
Tips on getting the most from your alopecia pathology reports Lynne J. Goldberg, MD J a g Bhawan Professor o f Dermatology a n d Pathology & Laboratory Medicine Boston U n iversity School of Medicine D
More informationLuminal early breast cancer: (neo-) adjuvant endocrine therapy
CAMPUS GROSSHADERN CAMPUS INNENSTADT KLINIK UND POLIKLINIK FÜR FRAUENHEILKUNDE UND GEBURTSHILFE DIREKTOR: PROF. DR. MED. SVEN MAHNER Luminal early breast cancer: (neo-) adjuvant endocrine therapy Nadia
More informationExtended Hormonal Therapy
Extended Hormonal Therapy Dr. Caroline Lohrisch, Medical Oncologist, BC Cancer Agency Vancouver Centre November 1, 2014 www.fpon.ca Optimal Endocrine Therapy for Women with Hormone Receptor Positive Early
More informationSkin Deep Into Toxicities of Cancer Therapies. Mario E Lacouture MD Member, Memorial Hospital Director, Oncodermatology Program New York, NY
Skin Deep Into Toxicities of Cancer Therapies Mario E Lacouture MD Member, Memorial Hospital Director, Oncodermatology Program New York, NY Targeting the Immune System in Cancer. Sharma et al, Nat Rev
More informationTAO-Cancer Toxicity Management: Cutaneous Toxicities of Immunotherapies
TAO-Cancer Toxicity Management: Cutaneous Toxicities of Immunotherapies Mario E Lacouture MD Director, Oncodermatology Program Attending, Dermatology www. MSKCC.org Dermatologic Care With Immunotherapies
More informationEndocrine Therapy 2017: Is There a Better Single Agent and when Should we Use it?
Endocrine Therapy 2017: Is There a Better Single Agent and when Should we Use it? ET1 ET2 ET3 Targeted agent 1 Targeted agent 2 Hope S. Rugo, MD Director, Breast Oncology and Clinical Trials Education
More informationAdjuvant Systemic Therapy in Early Stage Breast Cancer
Adjuvant Systemic Therapy in Early Stage Breast Cancer Julie R. Gralow, M.D. Director, Breast Medical Oncology Jill Bennett Endowed Professor of Breast Cancer Professor, Global Health University of Washington
More informationLessons Learnt from Neoadjuvant Hormone Therapy. 10 Lessons Learnt from Neoadjuvant Endocrine Therapy. Lesson 1
Lessons Learnt from Neoadjuvant Hormone Therapy Mike Dixon Clinical Director Breakthrough Research Unit Edinburgh 10 Lessons Learnt from Neoadjuvant Endocrine Therapy 10 Lessons Learnt from Neoadjuvant
More informationLessons Learnt from Neoadjuvant Hormone Therapy. Mike Dixon Clinical Director Breakthrough Research Unit Edinburgh
Lessons Learnt from Neoadjuvant Hormone Therapy Mike Dixon Clinical Director Breakthrough Research Unit Edinburgh 10 Lessons Learnt from Neoadjuvant Endocrine Therapy 10 Lessons Learnt from Neoadjuvant
More informationScalp Cooling to Prevent Chemotherapy-Induced Alopecia
Scalp Cooling to Prevent Chemotherapy-Induced Alopecia Julie Nangia, MD Director of the Breast Cancer Prevention & High Risk Program Baylor College of Medicine Background Chemotherapy treats micro-metastatic
More informationThe Latest Research: Hormonal Therapies
The Latest Research: Hormonal Therapies Sameer Gupta, M.D., M.P.H 9/29/2018 Attending Physician, Hematology/Oncology Bryn Mawr Hospital Clinical Assistant Professor, Jefferson Medical College Disclosures
More informationMetastatic breast cancer: sequence of therapies
Metastatic breast cancer: sequence of therapies Clinical Case Discussion Nadia Harbeck, MD PhD Breast Center, Department of Gynecology and Obstetrics University of Munich, Ludwig-Maximilians University
More informationBad to the bones: treatments for breast and prostate cancer
12 th Annual Osteoporosis: New Insights in Research, Diagnosis, and Clinical Care 23 rd July 2015 Bad to the bones: treatments for breast and prostate cancer Richard Eastell, MD FRCP (Lond, Edin, Ireland)
More informationA Layperson's Guide to Endocrine (Hormone) Therapy
A Layperson's Guide to Endocrine (Hormone) Therapy What we will cover What is the endocrine system Basic definition of endocrine therapy Classes of endocrine drugs How you can utilise endocrine therapy
More informationHow to decipher a pathology report for alopecia
How to decipher a pathology report for alopecia DISCLOSURE OF RELATIONSHIPS WITH INDUSTRY Lynne J. Goldberg, MD S063-Hair Disorders Made Easier DISCLOSURES I do not have any relationships with industry
More informationUpdate on New Perspectives in Endocrine-Sensitive Breast Cancer. James R. Waisman, MD
Update on New Perspectives in Endocrine-Sensitive Breast Cancer James R. Waisman, MD Nothing to disclose DISCLOSURE TAILORx Oncotype Recurrence Score TAILORx Study Design Sparano, J Clin Oncol 2008;26:721-728
More informationBREAST CANCER AND BONE HEALTH
BREAST CANCER AND BONE HEALTH Rowena Ridout, MD, FRCPC Toronto Western Hospital Osteoporosis Program University Health Network / Mount Sinai Hospital rowena.ridout@uhn.ca None to declare Conflicts of Interest
More informationGiuseppe Viale for the BIG 1 98 Collaborative and International Breast Cancer Study Groups
Central Review of ER, PgR and HER2 in BIG 1 98 Evaluating Letrozole vs. Letrozole Tamoxifen vs. Tamoxifen Letrozole as Adjuvant Endocrine Therapy for Postmenopausal Women with Hormone Receptor Positive
More informationSeigo Nakamura,M.D.,Ph.D.
Seigo Nakamura,M.D.,Ph.D. Professor of Surgery Director of Breast Center Showa University Hospital Chairman of the board of directors Japan Breast Cancer Society Inhibition of Estrogen-Dependent Growth
More informationIntegrated care: guidance on fracture prevention in cancer-associated bone disease; treatment options
Paris, November 1st 2016 Integrated care: guidance on fracture prevention in cancer-associated bone disease; treatment options René Rizzoli MD International Osteoporosis Foundation and Division of Bone
More informationDaniel Asz Sigall, MD MEXICO
Daniel Asz Sigall, MD MEXICO Scalp dermoscopy 1) Hair shaft diameter heterogeneity 2) Short regrowing hairs 3) Single- hair pilosebaceous units 4) Yellow dots 5) peripilar sign 6) Honeycomb pigmentation
More informationBREAST JOURNAL CLUB LONG-TERM OUTCOME RESULTS OF THE PHASE III PROMISE- GIM6 STUDY EVALUATING THE ROLE OF LHRH ANALOG
BREAST JOURNAL CLUB LONG-TERM OUTCOME RESULTS OF THE PHASE III PROMISE- GIM6 STUDY EVALUATING THE ROLE OF LHRH ANALOG (LHRHa) DURING CHEMOTHERAPY AS A STRATEGY TO REDUCE OVARIAN FAILURE IN EARLY BREAST
More informationEmerging Approaches for (Neo)Adjuvant Therapy for ER+ Breast Cancer
Emerging Approaches for (Neo)Adjuvant Therapy for E+ Breast Cancer Cynthia X. Ma, M.D., Ph.D. Associate Professor of Medicine Washington University in St. Louis Outline Current status of adjuvant endocrine
More informationTreatment of Metastatic Breast Cancer. Prof RCCoombes Imperial College London
Treatment of Metastatic Breast Cancer Prof RCCoombes Imperial College London Metastatic Breast Cancer: General Guidelines Specialized oncology nurses (if possible specialized breast nurses) should be part
More informationChemo-endocrine prevention of breast cancer
Chemo-endocrine prevention of breast cancer Andrea DeCensi, MD Division of Medical Oncology Ospedali Galliera, Genova; Division of Cancer Prevention and Genetics, European Institute of Oncology, Milano;
More informationPage. Objectives: Hormone Therapy Resistance: Challenges and Opportunities. Research Support From Merck
Hormone Therapy Resistance: Challenges and Opportunities Pamela. N. Munster, MD University of California, San Francisco Financial Disclosures Research Support From Merck Objectives: Understanding the current
More informationJohns Hopkins Clinical Update Webinar
Johns Hopkins Clinical Update Webinar Ben Ho Park, M.D., Ph.D. Department of Oncology Johns Hopkins University February 2015 This presentation is the intellectual property of the author/presenter. Contact
More informationpan-canadian Oncology Drug Review Final Economic Guidance Report Palbociclib (Ibrance) for Advanced Breast Cancer Resubmission November 21, 2016
pan-canadian Oncology Drug Review Final Economic Guidance Report Palbociclib (Ibrance) for Advanced Breast Cancer Resubmission November 21, 2016 DISCLAIMER Not a Substitute for Professional Advice This
More informationStudy Of Letrozole Extension. Coordinating Group IBCSG IBCSG BIG 1-07
tudy Of Letrozole Extension Coordinating Group IBCSG IBCSG 35-07 BIG 1-07 A phase III trial evaluating the role of continuous letrozole versus intermittent letrozole following 4 to 6 years of prior adjuvant
More informationLong Term Toxicity of Endocrine Therapy for premenopausal women with ER positive breast cancer
Global Breast Cancer Conference 2017 21 st Apr, 2017@Chezu Island Long Term Toxicity of Endocrine Therapy for premenopausal women with ER positive breast cancer Shinji Ohno, M.D., Ph.D., F.A.C.S. Breast
More informationSystemic Treatment of Breast Cancer. Hormone Therapy and Chemotherapy, Curative and Palliative
Systemic Treatment of Breast Cancer Hormone Therapy and Chemotherapy, Curative and Palliative Systemic Therapy Invasive breast cancers Two forms Curative Palliative Curative Systemic Therapy Adjuvant Therapy
More informationA Slow Starvation: Adjuvant Endocrine Therapy of Breast Cancer
A Slow Starvation: Adjuvant Endocrine Therapy of Breast Cancer Dr. Susan Ellard Surgical Oncology Update October 24, 2009 Disclosure slide Participant in various meetings or advisory boards sponsored by
More informationATAC Trial. 10 year median follow-up data. Approval Code: AZT-ARIM-10005
ATAC Trial 10 year median follow-up data Approval Code: AZT-ARIM-10005 Background FDA post-approval commitment analysis to update DFS, TTR, OS and Safety Prof. Jack Cuzick on behalf of ATAC/LATTE Trialists
More information4.7 Studies of Quality Holy Cross Hospital Bone Health Early Stage I ER/PR Positive Breast Cancer Patients December 13, 2017
4.7 Studies of Quality Holy Cross Hospital 2017 Bone Health Early Stage I ER/PR Positive Breast Cancer Patients December 13, 2017 Bone Health in Stage I ER/PR Positive Breast Cancer Patients To review
More information6/8/2017. Disclosure. High MBD Genetic vs hormonal effects. Hypotheses
1 Disclosure Stephen N Birrell MD PhD FRACS Co-Founder Chief Medical Officer Nicholas D Birrell BSc (Hons), MSc, PhD Scientific Advisor An open labelled evaluation of subcutaneous combined testosterone
More informationManejo do câncer de mama RH+ na adjuvância: o que há de novo?
II Simpósio Internacional de Câncer de Mama para o Oncologista Clínico Manejo do câncer de mama RH+ na adjuvância: o que há de novo? INGRID A. MAYER, MD, MSCI Assistant Professor of Medicine Director,
More information03/14/2019. GnRH Analogs for Fertility Preservation: What are the Data? Educational Objectives. Outline
GnRH Analogs for Fertility Preservation: What are the Data? AHN-JH SKCCC Current Topics in Breast Cancer Symposium Karen Lisa Smith MD MPH Assistant Professor Johns Hopkins Breast and Cancer Program March
More informationpan-canadian Oncology Drug Review Initial Economic Guidance Report Palbociclib (Ibrance) for Advanced Breast Cancer May 5, 2016
pan-canadian Oncology Drug Review Initial Economic Guidance Report Palbociclib (Ibrance) for Advanced Breast Cancer May 5, 2016 DISCLAIMER Not a Substitute for Professional Advice This report is primarily
More informationCase. 24 year old female presented to your office complaining of excess hair growth on her face and abdomen. Questions?
Hirsutism Case 24 year old female presented to your office complaining of excess hair growth on her face and abdomen Questions? Started around puberty with gradual progression Irregular menstrual cycle
More informationChoosing between different hormonal therapies. Rudy Van den Broecke UZ Ghent
Choosing between different hormonal therapies Rudy Van den Broecke UZ Ghent What is the golden standard in premenopausal hormonal sensitive early breast cancer? Ovarian Suppression alone 5 years Tamoxifen
More informationCohort D Xentuzumab + abemaciclib + fulvestrant (500 mg/month) Key exclusion criteria RP2D-4 NSCLC. Cohort F Xentuzumab + abemaciclib + fulvestrant
A phase Ib trial of xentuzumab and abemaciclib in patients with locally advanced or metastatic solid tumors, including hormone receptor-positive, HER2-negative breast cancer (plus endocrine therapy) Douglas
More informationOnline-Only Supplementary Materials
Online-Only Supplementary Materials Online-Only Supplementary Methods: Eligibility Criteria and Study Endpoints and Assessments Supplementary Table 1. Demographic and Baseline Characteristics in Patients
More informationWhat is new in HR+ Breast Cancer? Olivia Pagani Breast Unit and Institute of oncology of Southern Switzerland
What is new in HR+ Breast Cancer? Olivia Pagani Breast Unit and Institute of oncology of Southern Switzerland Outline Early breast cancer Advanced breast cancer Open questions Outline Early breast cancer
More informationBreast Cancer and Bone Loss. One in seven women will develop breast cancer during a lifetime
Breast Cancer and Bone Loss One in seven women will develop breast cancer during a lifetime Causes of Bone Loss in Breast Cancer Patients Aromatase inhibitors Bil Oophorectomy Hypogonadism Steroids Chemotherapy
More informationEndocrine Therapy of Metastatic Breast Cancer
Diagnosis and Treatment of Patients with Primary and Metastatic Breast Cancer Endocrine Therapy of Metastatic Breast Cancer Endocrine Therapy of Metastatic Breast Cancer Version 2002: Gerber / Friedrichs
More informationCollaborative Management of Patients With Advanced Estrogen Receptor Positive Breast Cancer
Collaborative Management of Patients With Advanced Estrogen Receptor Positive Breast Cancer Lee Schwartzberg, MD, FACP Heather Greene, FNP, AOCNP West Cancer Center Memphis, Tennessee Learning Objectives
More informationSupplementary Online Content
Supplementary Online Content Spring LM, Gupta A, Reynolds KL, et al. Neoadjuvant endocrine therapy for estrogen receptor positive breast cancer: a systematic review and meta-analysis. JAMA Oncol. Published
More informationIncreased Risk of Breast Cancer: Screening and Prevention. Elizabeth Pritchard, MD 4/5/2017
Increased Risk of Breast Cancer: Screening and Prevention Elizabeth Pritchard, MD 4/5/2017 No disclosures Defining Risk Risk Factors Modifiable Lifestyle obesity physical activity alcohol consumption breast
More informationTRIALs of CDK4/6 inhibitor in women with hormone-receptor-positive metastatic breast cancer
TRIALs of CDK4/6 inhibitor in women with hormone-receptor-positive metastatic breast cancer Marta Bonotto Department of Oncology University Hospital of Udine TRIALs of CDK4/6 inhibitor in women with hormone-receptor-positive
More informationSystemic Management of Breast Cancer
Systemic Management of Breast Cancer Why Who When What How long Etc. Vernon Harvey Rotorua, June 2014 Systemic Management of Breast Cancer Metastatic Disease Adjuvant Therapy Aims of therapy Quality of
More informationpcodr EXPERT REVIEW COMMITTEE (perc) INITIAL RECOMMENDATION
pcodr EXPERT REVIEW COMMITTEE (perc) INITIAL RECOMMENDATION The pan-canadian Oncology Drug Review (pcodr) was established by Canada s provincial and territorial Ministries of Health (with the exception
More information6/22/2017 TARGETING THE TARGETS IN 2017 TARGETING THE TARGETS IN 2017
TARGETING THE TARGETS IN 2017 Primary Care Focus Symposium July 1, 2017 Grace Wang MD I do not have any relevant financial relationships to disclose at this time TARGETING THE TARGETS IN 2017 What are
More informationRadiation therapy Radiation therapy is a cancer treatment that uses high-energy x-rays or other types of radiation to kill cancer cells or keep them from growing. Chemotherapy Chemotherapy is a cancer
More informationOnco-fertility. Fertility issues in young women with breast cancer in Japan. National Cancer Center Hospital, Tokyo Chikako Shimizu, MD
Onco-fertility Fertility issues in young women with breast cancer in Japan National Cancer Center Hospital, Tokyo Chikako Shimizu, MD COI disclosure Chikako Shimizu receives contracted research fund from
More informationApproach to ovulation induction and superovulation in women with a history of infertility. Anatte E. Karmon, MD
Approach to ovulation induction and superovulation in women with a history of infertility Anatte E. Karmon, MD Disclosures- Anatte Karmon, MD No financial relationships to disclose 2 Objectives At the
More informationEndocrine Therapy in Premenopausal Breast Cancer. Joyce O Shaughnessy, MD Baylor Sammons Cancer Center Texas Oncology, PA US Oncology
Endocrine Therapy in Premenopausal Breast Cancer Joyce O Shaughnessy, MD Baylor Sammons Cancer Center Texas Oncology, PA US Oncology Ovarian Ablation or Suppression vs. Not in ER + or ER UK Breast Cancer
More informationRadiation and DCIS. The 16 th Annual Conference on A Multidisciplinary Approach to Comprehensive Breast Care and Imaging
Radiation and DCIS The 16 th Annual Conference on A Multidisciplinary Approach to Comprehensive Breast Care and Imaging Einsley-Marie Janowski, MD, PhD Assistant Professor Department of Radiation Oncology
More informationMultimedia Appendix 6 Educational Materials Table of Contents. Intervention Educational Materials Audio Script (version 1)
Multimedia Appendix 6 Educational Materials Table of Contents Intervention Educational Materials... 1 Audio Script (version 1)... 1 Text (version 1)... 5 Slides (version 1)... 17 Audio Script (version
More informationSetting The study setting was secondary care. The economic study was carried out in Norway.
Comparing cost/utility of giving an aromatase inhibitor as monotherapy for 5 years versus sequential administration following 2-3 or 5 years of tamoxifen as adjuvant treatment for postmenopausal breast
More informationWhen is Chemotherapy indicated in Advanced Luminal Breast Cancer?
When is Chemotherapy indicated in Advanced Luminal Breast Cancer? Soo-Chin Lee Head & Senior Consultant Department of Haematology-Oncology Clinical Care National University Cancer Institute, Singapore
More informationSupplementary Online Content
Supplementary Online Content Rugo HS, Klein P, Melin SA, et al. Association between use of a scalp cooling device and alopecia after chemotherapy for breast cancer. JAMA. doi:10.1001/jama.2016.21038 Additional
More informationQamar J. Khan Bruce F. Kimler Pavan S. Reddy Priyanka Sharma Jennifer R. Klemp Carol J. Fabian
The VITAL trial Randomized trial of vitamin D3 to prevent worsening of musculoskeletal symptoms and fatigue in women with breast cancer starting adjuvant letrozole. Qamar J. Khan Bruce F. Kimler Pavan
More informationThe efficacy of second-line hormone therapy for recurrence during adjuvant hormone therapy for breast cancer
517734TAM6210.1177/1758834013517734Therapeutic Advances in Medical OncologyR Mori and Y Nagao research-article2013 Therapeutic Advances in Medical Oncology Original Research The efficacy of second-line
More informationHormonal therapies for the adjuvant treatment of early breast cancer
Society for Endocrinology comments on the assessment report for the National Institute for Health and Clinical Excellence Appraisal of Hormonal therapies for the adjuvant treatment of early breast cancer
More informationMetastatic Breast Cancer What is new? Subtypes and variation?
Metastatic Breast Cancer What is new? Subtypes and variation? Anne Blaes, MD, MS University of Minnesota, Division of Hematology/Oncology Director, Adult Cancer Survivor Program Current estimates for metastatic
More informationOutline of the presentation
Outline of the presentation Breast cancer subtypes and classification Clinical need in estrogen-positive (ER+) metastatic breast cancer (mbc) Sulforaphane and SFX-01: the preclinical evidence STEM Phase
More informationBreast cancer. Prof Arlene Chan Medical Oncologist Director Breast Clinical Trials Unit, Mount Hospital Vice-Chair Breast Cancer Research Centre - WA
Breast cancer rof Arlene Chan Medical Oncologist Director Breast Clinical Trials Unit, Mount Hospital Vice-Chair Breast Cancer Research Centre - WA Breast cancer Incidence of Breast Cancer by Stage at
More informationThe worldwide overview: updated (2005-6) meta-analyses of hormonal treatment trials
The worldwide overview: updated (2005-6) meta-analyses of hormonal treatment trials Richard Gray, for the Early Breast Cancer Trialists Collaborative Group (EBCTCG) Main questions, 2005-6 1) 5 years of
More informationTAS-108: A Novel Steroidal Anti-Estrogen for Treatment of Breast Cancer
SRI Biosciences TAS-108: A Novel Steroidal Anti-Estrogen for Treatment of Breast Cancer Potential Indications Neo-adjuvant therapy for ER + primary breast cancers in premenopausal women Adjuvant therapy
More informationEndocrine Steroids 2. Signal transduction 3. Prostaglandins
Endocrine - 2 1. Steroids 2. Signal transduction 3. Prostaglandins Estrogen Menopause (pause in the menes) ["change of life" at about 50] - lack of estrogen. (Some hysterectomy or ovarian cancer surgeries
More informationEvaluation of efficacy and safety of finasteride 1 mg in 3177 Japanese men with androgenetic alopecia
doi:./j.46-88.2.78.x Journal of Dermatology 22; 9: 27 2 ORIGINAL ARTICLE Evaluation of efficacy and safety of finasteride mg in 77 Japanese men with androgenetic alopecia Akio SATO, Akira TAKEDA 2 Tokyo
More informationORMONOTERAPIA ADIUVANTE: QUALE LA DURATA OTTIMALE? MARIANTONIETTA COLOZZA
ORMONOTERAPIA ADIUVANTE: QUALE LA DURATA OTTIMALE? MARIANTONIETTA COLOZZA THE NATURAL HISTORY OF HORMONE RECEPTOR- POSITIVE BREAST CANCER IS VERY LONG Recurrence hazard rate 0.3 0.2 0.1 0 ER+ (n=2,257)
More informationUpdates From San Antonio Breast Cancer Symposium 2017
Updates From San Antonio Breast Cancer Symposium 2017 Rob Coleman University of Sheffield Presentation Outline New Insights into adjuvant endocrine treatment Duration of treatment Perioperative therapy
More information38 years old, premenopausal, had L+snbx. Pathology: IDC Gr.II T-1.9cm N+2/4sn ER+100%st, PR+60%st, Her2-neg, KI %
38 years old, premenopausal, had L+snbx Pathology: IDC Gr.II T-1.9cm N+2/4sn ER+100%st, PR+60%st, Her2-neg, KI67 5-10% Question: What will you do now? 1. Give adjuvant chemotherapy 2. Send for Oncotype
More informationDetermining menopausal status in women receiving anti-oestrogen treatment. Luke Hughes-Davies Addenbrookes Hospital, Cambridge
Determining menopausal status in women receiving anti-oestrogen treatment Luke Hughes-Davies Addenbrookes Hospital, Cambridge Letter from GP 2017 Now that your patients are being discharged back to primary
More informationSurvivorship in Cancer Care. Samantha Gray Medical Oncologist, SJRH April 20, 2018
+ Survivorship in Cancer Care Samantha Gray Medical Oncologist, SJRH April 20, 2018 + Disclaimers n Participated in Advisory Boards for Amgen, Astellas, Bayer, Janssen, Novartis, Pfizer, Sanofi n Have
More informationAllergy, Atopy and Skin Cancer
M. Shane Cahpman, MD, MBA: Dartmouth School of Medicine Boni E. Elewski, MD: University of Alabama Kenneth J. Tomecki, MD: Cleveland Clinic Ted Rosen, MD: Baylor College of Medicine Clinical and Therapeutic
More informationIntro to Cancer Therapeutics
An Intro to Cancer Therapeutics Christopher R. Chitambar, MD Professor of Medicine Division of Hematology & Oncology Froedtert and Medical College of Wisconsin Clinical Cancer Center cchitamb@mcw.edu Intro
More informationA vision for HER2 future
School of Medical Oncology Department of Medical and Biological Sciences - University of Udine Department of Oncology - University Hospital of Udine A vision for HER2 future Current therapeutic algorithm
More informationThromboembolism and cancer: New practices. Marc Carrier
Thromboembolism and cancer: New practices Marc Carrier Marc Carrier Research Support/P.I. Employee Consultant Major Stockholder Speakers Bureau Honoraria Scientific Advisory Board Leo Pharma, BMS No relevant
More informationTherapeutic Cohort Results
Patient: SAMPLE PATIENT DOB: Sex: MRN: Menopause Plus - Salivary Profile Therapeutic Cohort Results Hormone Average Result QUINTILE DISTRIBUTION 1st 2nd 3rd 4th 5th Therapeutic Range* Estradiol (E2) 8.7
More informationBreast Cancer Survivorship. Michelle Melisko MD Assistant Clinical Professor UCSF Breast Care Center
Breast Cancer Survivorship Michelle Melisko MD Assistant Clinical Professor UCSF Breast Care Center Survivors Who are they? An estimated 210,000 women were diagnosed with breast cancer in the year 2007
More informationTargeted Agents In Breast Cancer. Wonderful Music With New Instruments
Targeted Agents In Breast Cancer Wonderful Music With New Instruments 1 Trends In Cancer Mortality In Women in US At This Rate We Will Beat Breast Cancer In 2040 Is the cause screening?? Is the cause better
More information2014 Oncology Measures Group Overview
2014 Oncology Measures Group Overview The Oncology Measures Group is a reporting option that significantly reduces the burden of participation in the Physician Quality Reporting System (PQRS). Source:
More informationCurrent Optimal Sequence and Duration of Endocrine Treatment
[Symposium 7] Present and Future of Endocrine Therapy 07 Apr, 2018@GBCC Current Optimal Sequence and Duration of Endocrine Treatment Breast Oncology Center The Cancer Institute Hospital of JFCR Shinji
More information10/15/2012. Overcoming Endocrine Therapy Resistance. The Problem in ER+ Tumors is Endocrine Therapy Resistance
Overcoming Endocrine Therapy Resistance Joyce O Shaughnessy, MD Baylor Sammons Cancer Center Texas Oncology US Oncology Slide Credits: Hope Rugo, MD The Problem in ER+ Tumors is Endocrine Therapy Resistance
More informationEarly Stage Disease. Hope S. Rugo, MD Professor of Medicine Director Breast Oncology and Clinical Trials Education UCSF Comprehensive Cancer Center
SABCS 2014: Early Stage Disease Hope S. Rugo, MD Professor of Medicine Director Breast Oncology and Clinical Trials Education UCSF Comprehensive Cancer Center Topics for Discussion Chemotherapy plus 10
More informationBreast cancer (radio)biology: hormonal treatments and aromatase-inhibitors
Breast cancer (radio)biology: hormonal treatments and aromatase-inhibitors M. Buglione, L. Costa, S. Grisanti, N. Pasinetti Department of Radiation Oncology, University of Brescia Department of Medical
More informationTerapia adiuvante con inibitori delle Kinasi Cliclina Dipendenti 4/6: quale futuro? Filippo Montemurro
Terapia adiuvante con inibitori delle Kinasi Cliclina Dipendenti 4/6: quale futuro? Filippo Montemurro Unit of Investigative Clinical Oncology Istituto di Candiolo (IRCCS) Disclosures Speaker s Honoraria
More informationREFERENCE NUMBER: NH.PST.05 EFFECTIVE DATE: 10/10
PAGE: 1 of 5 IMPORTANT REMINDER This Clinical Policy has been developed by appropriately experienced and licensed health care professionals based on a thorough review and consideration of generally accepted
More informationSetting The setting was secondary care. The economic study was carried out in Canada.
Anastrozole is cost-effective vs tamoxifen as initial adjuvant therapy in early breast cancer: Canadian perspectives on the ATAC completed-treatment analysis Rocchi A, Verma S Record Status This is a critical
More informationpan-canadian Oncology Drug Review Final Clinical Guidance Report Everolimus (Afinitor) for Advanced Breast Cancer March 25, 2013
pan-canadian Oncology Drug Review Final Clinical Guidance Report Everolimus (Afinitor) for Advanced Breast Cancer March 25, 2013 DISCLAIMER Not a Substitute for Professional Advice This report is primarily
More informationMechanisms of Resistance to. Lisa A. Carey, M.D. University of North Carolina at Chapel Hill Lineberger Comprehensive Cancer Center
Mechanisms of Resistance to Hormonal Therapy Lisa A. Carey, M.D. University of North Carolina at Chapel Hill Lineberger Comprehensive Cancer Center Antagonizing Estrogen Dependent Growth Premenopausal
More informationBreast Cancer. Dr. Andres Wiernik 2017
Breast Cancer Dr. Andres Wiernik 2017 Agenda: The Facts! (Epidemiology/Risk Factors) Biological Classification/Phenotypes of Breast Cancer Treatment approach Local Systemic Agenda: The Facts! (Epidemiology/Risk
More informationOPTIMAL ENDOCRINE THERAPY IN EARLY BREAST CANCER
OPTIMAL ENDOCRINE THERAPY IN EARLY BREAST CANCER STEPHEN E. JONES, M.D. US ONCOLOGY RESEARCH THE WOODLANDS, TX TOPICS PREMENOPAUSAL BREAST CANCER POSTMENOPAUSAL BREAST CANCER THE FUTURE TOPICS PREMENOPAUSAL
More informationWilliam J. Gradishar MD
Northwestern University Feinberg School of Medicine Adjuvant Endocrine Therapy For Postmenopausal Women SOBO 2013 William J. Gradishar MD Betsy Bramsen Professor of Breast Oncology Director, Maggie Daley
More informationScottish Medicines Consortium
Scottish Medicines Consortium anastrozole 1mg tablets (Arimidex ) No. (198/05) AstraZeneca UK Ltd New indication: for adjuvant treatment of postmenopausal women with hormone receptorpositive early invasive
More information