Outcomes of Adult Dual Kidney Transplants by KDRI in the United States
|
|
- Linda Webb
- 5 years ago
- Views:
Transcription
1 American Journal of Transplantation 2013; 13: Wiley Periodicals Inc. Brief Communication C Copyright 2013 The American Society of Transplantation and the American Society of Transplant Surgeons doi: /ajt Outcomes of Adult Dual Kidney Transplants by KDRI in the United States T. Klair 1, A. Gregg 2, J. Phair 3 and L. K. Kayler 4, * 1 Department of Surgery, Einstein College of Medicine, Bronx, NY 2 Department of Medicine, University of Florida, Gainesville, FL 3 Department of Medicine, Einstein College of Medicine, Bronx, NY 4 Department of Surgery, Montefiore Medical Center, Bronx, NY *Corresponding author: Liise Kayler, liisekayler@yahoo.com UNOS guidelines provide inadequate discriminatory criteria for kidneys that should be transplanted as single (SKT) versus dual (DKT). We evaluated the utility of the kidney donor risk index (KDRI) to define kidneys with better outcomes when transplanted as dual. Using SRTR data from 1995 to 2010 of de novo KTX recipients of adult deceased-donor kidneys, we examined outcomes of SKT and DKT stratified by KDRI group 1.4 (n ¼ ), (n ¼ ), (n ¼ 6523) and >2.2 (n ¼ 2791). DKT of kidneys with KDRI >2.2 was associated with significantly better overall graft survival [adjusted hazard ratio (ahr) 0.83, 95% confidence interval (CI) ] compared to single kidneys with KDRI >2.2. DKT was associated with significantly decreased odds of delayed graft function (top 2 KDRI categories) and significantly decreased odds of 1-year serum creatinine level >2 mg/dl (top 3 KDRI categories). Among SKT and DKT from KDRI >2.2 there were 16.1 and 13.9 graft losses per 100 patient follow-up years, respectively. KDRI >2.2 is a useful discriminatory cut-off for the determination of graft survival benefit with the use of DKT; however, the benefit of increased graft years was less than half of single kidneys from donors in the same KDRI range. Key words: Dual, KDRI, kidney transplantation Abbreviations: AHR, adjusted hazard ratio; AOR, adjusted odds ratio; BMI, body mass index; CI, confidence interval; CIT, cold ischemia time; CVA, cerebrovascular accident; DCD, donation after circulatory death; DKT, dual kidney transplantation; HLA, human leukocyte antigen; HRSA, health resources and services administration; OPO, organ procurement organization; OPTN, organ procurement and transplantation network; PRA, panel reactive antibody; SD, standard deviation; SKT, single kidney transplantation; SRTR, scientific registry of transplant recipients. Received 29 March 2013, revised and accepted 11 June 2013 Introduction The use of marginal donor kidneys has become an increasingly accepted method to expand the donor pool; however, the quality of the donated organ in kidney transplantation is one of the most crucial factors for graft survival. Concerns over the limited life span of marginal kidneys have led some surgeons to perform dual kidney transplantation based on the concept that poor long-term outcomes may be the consequence of an imbalance between the number of viable nephrons supplied and the metabolic demand of the recipient (1); therefore, concurrent transplantation of two kidneys into one recipient would increase nephron dosing (2) and maximize outcomes (3 14). Various reports have demonstrated improved graft survival or function with the use of dual rather than single kidney implantation when risk factors predict poor graft function. Criteria or scoring systems for choosing to perform dual transplantation have generally included older donor age and one or more other parameter(s) such as preimplant biopsy, donor estimated creatinine clearance, kidney weight, machine perfusion characteristics and/or long cold ischemia time (2 14). However, it is not always clear whether the criteria utilized is robust enough to select which marginal donor kidneys should be used together in order to maximize successful outcomes without reducing the organ supply that is by dual grafting when a single graft would suffice. Current UNOS policy states that kidneys from adult donors must be offered singly unless the offering OPO would not use the kidneys singly and the donor meets at least two of the following conditions: (1) age >60 years, (2) estimated creatinine clearance less than 65 ml/min based on admission serum creatinine, (3) terminal serum creatinine >2.5 mg/dl, (4) history of longstanding hypertension or diabetes mellitus and (5) histologic findings of glomerulosclerosis 16 49%. Unfortunately, UNOS criteria do not adequately identify ECD kidneys that would confer a graft survival advantage if transplanted as dual (15). 2433
2 Klair et al. The OPTN/United Network for Organ Sharing (UNOS) Kidney Transplantation Committees (KTC) recent proposal of a modified version of the kidney donor risk index (KDRI) originally described by Rao et al. (16) as a tool to improve risk assessment may also serve as useful scoring system to guide dual kidney allocation. The UNOS KDRI incorporates multiple donor parameters into a single metric quantifying risk for graft failure along a continuum. To examine the utility of the KDRI to define kidneys with better outcomes when transplanted as DKT, we examined the outcomes of dual and single kidneys for any given level of donor risk as measured by the UNOS KDRI. Materials and Methods Study design and participants We utilized data from the Scientific Registry of Transplant Recipients (SRTR). The SRTR data system includes data on all donor, wait-listed candidates, and transplant recipients in the United States, submitted by the members of the Organ Procurement and Transplantation Network (OPTN). The Health Resources and Services Administration (HRSA), U.S. Department of Health and Human Services provides oversight to the activities of the OPTN and SRTR contractors. Using the SRTR Standard Analysis File, we conducted a retrospective cohort study of patients receiving a deceased-donor kidney transplants (KTX) in the United States from January 1, 1995 to December 31, 2010 with last followup data available from October Exclusion criteria included (1) multiorgan transplant recipients, (2) previous transplant recipients, (3) ABO incompatible transplants, (4) donor or recipient age less than 18 years, (5) recipients with human immunodeficiency virus and (6) patients with missing data to calculate the KDRI. Exposure and outcome classification and assessment We utilized the KDRI model adopted by the UNOS/OPTN which includes 10 deceased-donor variables ( ContentDocuments/Guide _to_calculating_interpreting_kdpi.pdf; February 28, 2012). The KDRI was categorized into deciles, and plotted by transplant type (single vs. dual). We examined the distribution of the KDRI score at 0.2 and 0.4 intervals and in order to achieve analyzable groups, the KDRI was categorized into four groups using 0.4 intervals: 1.4, , and >2.2 which represented 66.4%, 21.1%, 8.8% and 3.8% of the transplanted kidneys, respectively. The primary outcome was graft failure which was defined as the earliest of retransplantation, return to dialysis, or patient death. Secondary outcomes were (1) death-censored graft failure (defined as retransplantation or return to dialysis), (2) patient mortality from any cause following transplantation, (3) delayed graft function (defined as at least one dialysis session within the first week posttransplantation) and (4) creatinine level >2.0 at one year. For the DGF analysis only, recipients with unknown dialysis status at the time of transplantation, those preemptively transplanted, and cases with primary nonfunction were excluded. Data on 1-year serum creatinine were missing in 14%. Of recovered adult kidneys, rates of discard were calculated during the same time frame across KDRI groups. The discard rate was defined as the number of kidneys not transplanted, divided by the total number of kidneys recovered for transplantation. Potential confounders The following recipient factors were included in the models: age (continuous), sex, race (African-American, other), duration of maintenance dialysis prior to transplantation (none, 3 years, >3 years, missing), number of HLA-A, B and DR mismatches (3, >3), panel-reactive antibody (PRA) level (>30%, 30%, missing), body mass index (30 kg/m 2, >30 kg/m 2, missing), cold ischemia time (hours; 12, 12 24, >24, missing), insurance status (private, other) and year of transplantation. Statistical analysis Baseline characteristics by dual (DKT)/single (SKT) kidney transplant status were compared with the chi-square test for categorical variables and the t-test for continuous variables whose distribution approximated normality. Continuous variables were examined for outliers, and cases with values thought to be clinically implausible were recoded as missing. The distributions of KDRI across DKT/SKT categories were visually explored using histograms. The Kaplan Meier method was used to assess time to graft failure by DKT/SKT type across KDRI categories. The log-rank test was used to evaluate differences between survival curves. Cox proportional hazards models were fitted to examine the independent association between DKT/SKT status at each KDRI quartile for the time to event outcomes while adjusting for potential recipient confounders. A model was fitted for each KDRI category and stratified by transplant type (SKT vs. DKT). Time to death or failure was determined from the date of transplant until outcome, censored for loss to follow-up, end of study period (October 31, 2011). Covariates in the Cox models were assessed for adherence to the proportional hazard assumption. No important departures from proportionality were observed. Logistic regression models were fitted to examine the relationship between DKT/SKT status across each KDRI quartile and risk of DGF or 1-year creatinine >2.0 mg/dl while adjusting for potential recipient confounders. Multivariable models were fitted with the results from cases that had complete data. No data were imputed. All analyses were performed using SAS software, version 9.2 (SAS Institute, Inc., Cary, NC). Statistical significance was identified by a p-value of less than 0.05 and all confidence intervals also used a 95% threshold. This study was approved by the Albert Einstein College of Medicine internal review board. Results A total of kidney transplant recipients were included in the study cohort. There were 1308 in the DKT group and in the SKT group. Of 1308 DKT, 11% (n ¼ 141), 25% (n ¼ 321), 30% (n ¼ 397) and 34% (n ¼ 449) of the kidneys were KDRI category 0 1.4, , and >2.2, respectively. Of the SKT 67% (n ¼ 49153), 21% (n ¼ ), 8% (n ¼ 6126) and 3% (n ¼ 2342) were KDRI category 0 1.4, , and >2.2, respectively. DKT tended to have higher KDRI and SKT tended to have lower KDRI (Figure 1). Recipient and transplant characteristics between the DKT and SKT groups across each KDRI category are shown in Tables 1a and 1b. Patients receiving dual kidneys were more likely to be older, African-American, and have less pre-transplant dialysis duration. They were less likely to be obese and sensitized. There were fewer DKT recipients with glomerular disease, and more with diabetes or hypertension, as the listed 2434 American Journal of Transplantation 2013; 13:
3 KDRI in Dual Kidney Transplantation Figure 1: Distribution of single and dual kidney transplants by kidney donor risk index (KDRI). primary etiology of renal failure. DKT transplants had more HLA mismatches and longer cold ischemia times. Graft survival Kaplan Meier curves for graft failure stratified by DKT/SKT status across KDRI categories are shown in Figure 2. The cumulative probability of graft failure among DKT recipients was similar to that of SKT recipients with KDRI 1.4, , and ; but not >2.2 where DKT outcomes were superior. Five-year graft survival rates for SKT and DKT by KDRI were as follows: 1.4 (74%, 72%), (63%, 64%), (55%, 59%) and >2.2 (48%, 54%). On multivariate analysis, DKT was associated with significantly better graft survival with kidneys designated as KDRI >2.2 (adjusted hazard ratio (ahr) 0.83, 95% confidence interval (CI) 0.71, 0.96) relative to SKT, but no benefit of DKT was seen with kidneys from other KDRI categories (Table 2). Similar patterns were noted for the outcome of deathcensored graft failure where a significant protective effect was demonstrated with the DKT use of KDRI >2.2 grafts (ahr 0.79, 95% CI 0.65, 0.97). Graft year analysis Among KTX deriving from donors with KDRI >2.2, both kidneys were transplanted in 16.1% of 2759 cases. We compared the total number of graft losses per follow-up year between SKT and DKT transplants. There were 16.1 graft losses per 100 patient follow-up years among single kidney transplants and 13.9 graft losses per 100 patient American Journal of Transplantation 2013; 13: follow-up years among dual kidney transplants. Based on these numbers, the total number of graft years per kidney was higher among solitary transplants. Patient survival Five-year patient survival rates for SKT and DKT by KDRI were as follows: 1.4 (85%, 80%), (77%, 75%), (70%, 70%) and >2.2 (65%, 67%) On multivariate analysis, there were no differences in overall patient survival with the use of DKT with kidneys from any KDRI category; however there was a trend toward a survival benefit with each increasing category of KDRI (Table 3). Graft function The incidence of delayed graft function of SKT/DKT across the KDRI groups was 1.4 (23%, 30%), (32%, 31%), (35%, 29%) and >2.2 (36%, 26%), respectively. On multivariate analysis DKT was associated with significantly worse odds of DGF with KDRI 1.4 (aor 1.54, 95% CI 1.05, 2.27) and a protective effect with a monotonic decrease across the higher KDRI categories (aor 0.91, 95% CI ), (aor 0.69, 95% CI 0.54, 0.88) and >2.2 (aor 0.62, 95%CI 0.49, 0.79; Table 3). The incidence of serum creatinine >2.0 at 1 year was 22% for DKT and 17% for SKT; and across each KDRI group for SKT and DKTs respectively was 1.4 (10%, 9%), (22%,15%), (27%, 20%) and >2.2 (32%, 21%). 2435
4 Klair et al. Table 1a: Recipient characteristics single (SKT) and dual (DKT) kidney transplants 1 Characteristic % or mean SD SKT (n ¼ ) DKT (n ¼ 1308) p-value Kidney donor risk index (KDRI) < < > Age, years < Race, African-American Sex, Female Listed primary ESRD etiology < Diabetes Hypertensive nephrosclerosis Other Glomerulonephritis Recipient dialysis No dialysis < years >3 years Recipient BMI > 30 kg/m Peak PRA > 80% < Recipient CIT < > Recipient HLA MM > < Insurance, private ESRD, end-stage renal disease; BMI, body mass index; CIT, cold ischemia time; PRA, panel reactive antibodies; HLA, human leukocyte antigen mismatch. 1 Data not shown for recipients missing information on BMI (n ¼ ; 15.5%), panel reactive antibody (n ¼ 177; 0.2%), cold ischemia time (n ¼ 6404; 8.6%), insurance type (n ¼ 161; 0.2%), HLA mismatch (n ¼ 80; 0.1%) and duration of dialysis (n ¼ 4564; 6.2%). Table 1b: Recipient characteristics single (SKT) and dual (DKT) kidney transplants across KDRI groups 1 KDRI 1.4 KDRI KDRI KDRI 2.2 Characteristic % or mean SD SKT DKT SKT DKT SKT DKT SKT DKT Age, years African-American Sex, female ESRD etiology Diabetes Hypertension Other Glomerulonephritis Recipient dialysis No dialysis years >3 years BMI > 30 kg/m Peak PRA > 80% CIT > HLA MM > Insurance, private Within each KDRI category 0 1.4, , and >2.2, total sample sizes were ¼141, 321, 397 and 449 among DKT , , 6126 and 2342 among SKT, respectively American Journal of Transplantation 2013; 13:
5 KDRI in Dual Kidney Transplantation Figure 2: Kaplan Meier plots of overall graft survival by transplant type and (A) KDRI 0 1.4, (B) KDRI , (C) KDRI and (D) >2.2. On multivariate analysis, DKT was associated with significantly decreased odds of 1-year serum creatinine level >2 mg/dl, in the top 3 KDRI categories with 39%, 36% and 51% decreased odds, respectively (Table 3). Discard rates A total of adult-donor kidneys were recovered for transplantation and 5740 were not transplanted. Discard rates across KDRI categories 1.4, , and >2.2 were 2% (980/50 274), 8% (1357/17 031), 18% (1438/7951) and 41% (n ¼ 1965/4756), respectively. Discussion The results of our study demonstrate that KDRI serves as an adequate discrimination tool to determine when American Journal of Transplantation 2013; 13: graft survival can be improved with the use of dual rather than single kidney transplantation. In this analysis, KDRI >2.2 was the cut-off value that conferred significantly better overall graft survival with DKT. Our results confirm existing knowledge that DKT of marginal grafts is associated with significantly decreased odds of delayed graft function (demonstrated with top 2 KDRI categories). Lastly, DKT significantly reduces the odds of 1-year serum creatinine level >2 mg/dl (top 3 KDRI categories); this finding likely points to a better functional reserve of dual transplant recipients because of an enhanced nephron mass. Despite our finding of a significant difference in graft survival for recipients of DKT from high KDRI kidneys, the effect size is somewhat small (17%). And, although DKT kidneys from donors with a KDRI >2.2 did offer increased graft years, the protective benefit was substantially less 2437
6 Klair et al. Table 2: Multivariable Cox model of overall graft survival following transplantation of kidneys with KDRI of >2.2 (n ¼ 2730) Patient mortality Parameters (reference group) Adjusted hazard ratio (95% CI) Dual kidney transplantation (SKT) 0.83 ( ) Recipient age, continuous per year 1.02 ( ) Recipient race, African-American (other) ( ) Recipient female (male) 0.92 ( ) Recipient body mass index >30 kg/m 2 (other) 1.21 ( ) Recipient PRA >80 (PRA 80) 1.28 ( ) Recipient HLA-mismatches >3 (3) 1.03 ( ) Cold ischemia time, hours (<12) ( ) > ( ) Recipient insurance, non-private (private) 1.18 ( ) Recipient ESRD diagnosis (glomerulonephritis) Diabetes 1.39 ( ) Hypertension 1.14 ( ) Other 1.03 ( ) Dialysis duration prior to transplant (none) <3 years 1.28 ( ) 3 years 1.43 ( ) Transplant year 0.97 ( ) Machine perfusion 0.99 ( ) HLA, human leukocyte antigen; PRA, panel reactive antibody; SKT, single kidney transplantation. than half as compared to single kidneys from donors in the same KDRI range. Therefore, from a resource perspective, with the strong caveat that SKT may be more selectively allocated than DKT kidneys, solitary transplants may offer substantially more total graft years to the recipient population despite an elevated risk. In other words, among those donor kidneys that can be successfully transplanted as singles, two transplants offer significantly more cumulative graft survival than dual transplantation. However, from an individualistic and programmatic perspective, a small yet significant optimization in graft survival, along with other indices of graft function, may be preferable. Also to consider is the possibility of improving organ utilization with DKT. Often the decision-making rationale is not DKT versus SKT, but rather DKT versus discard. Since 41% of kidneys with KDRI >2.2 are discarded, there appears to be room for improved utilization. The UNOS KDRI designation is a granular risk assessment that classifies deceased-donor kidneys according to relative risk for graft loss. Although there are significant donor risk factors not captured by the index, such as biopsy characteristics, concordance statistics indicate that the tool is especially useful for distinguishing more extreme categories of graft failure risk ( gov/contentdocuments/guide_to_calculating_interpreting_ KDPI.pdf, 16). Our multivariable Cox proportional hazards model demonstrated a significant decrease in the risk of graft failure using DKT with KDRI >2.2; however there was a stepwise decrease in the point estimates for each of the top Table 3: Final multivariable Cox model for outcomes of DKT, relative to SKT, across the KDRI categories 1 Outcome KDRI 1.4 KDRI KDRI KDRI >2.2 Adjusted hazard ratio (95% CI) Graft survival 0.97 (0.72, 1.30) 1.00 (0.85, 1.19) 0.90 (0.78, 1.05) 0.83 ( ) Death-censored graft survival 0.88 (0.56, 1.38) 0.97 ( ) 0.86 (0.70, 1.06) 0.79 (0.65, 0.97) Patient survival 1.06 (0.76, 1.47) 1.03 (0.84, 1.25) 1.03 (0.87, 1.22) 0.91 (0.77, 1.07) Adjusted odds ratio (95% CI) Delayed graft function 1.54 (1.05, 2.27) 0.91 (0.70, 1.18) 0.69 (0.54, 0.88) 0.62 (0.49, 0.79) 1-year creatinine > (0.53, 1.93) 0.61 (0.43, 0.86) 0.64 (0.48, 0.85) 0.49 (0.37, 0.65) KDRI, kidney donor risk index. 1 Within each KDRI category 0 1.4, , and >2.2, total numbers of observations used for the graft and patient survival analyses were , , 6401 and 2730, respectively. Corresponding sample sizes for the DGF analysis were , , 5921 and 1616, respectively, and for the 1-year creatinine analysis were , , 4678 and 1915, respectively American Journal of Transplantation 2013; 13:
7 KDRI in Dual Kidney Transplantation 3 KDRI categories and a narrowing of the confidence interval toward significance in KDRI category , suggesting that with a larger sample of high-kdri kidneys the cut-off value for maximizing outcomes with DKT may be lower. Another compelling scoring system to determine criteria for DKT versus SKT was reported by Remuzzi et al. (14) in The authors reported the results of a multicenter prospective analysis demonstrating excellent short- and long-term results after allocation of kidneys from donors >60 years of age based on a pre-implant biopsy 12-point histologic scoring system proposed by the Dual Kidney Transplant Group that assesses vessels, glomeruli, tubules and interstitium. Their results suggest that the histologic evaluation of donor kidneys serves to reduce variability in prognosticating outcomes. Unfortunately, the absence of UNOS data on features other than glomerulosclerosis limits the ability to validate the usefulness of histopathology in predicting graft outcome with United States registry data. On examination of the characteristics of candidates chosen to receive DKT, it is clear that the recipients are older, thinner, more likely African-American and hypertensive or diabetic, less likely to be sensitized and have less time on dialysis. This suggests selection by transplant clinicians in the process of evaluating the most appropriate candidates for dual transplantation. Selection of optimal candidates is important in DKT because it is a more extensive procedure and is typically performed in elderly recipients which have less physiologic reserve than younger recipients. Despite the greater extent of the DKT procedure, complication rates have been shown to be comparable to those of single kidney transplants (13). DKT is a potential strategy to maintain access without impairing outcomes of transplantation for older candidates. If the proposed UNOS policy, released for public review in early 2011, of survival matching by KDRI is accepted, the distribution of younger organs with lower risk would shift to younger recipients and organs from older donors at higher risk of graft failure would be allocated primarily to older individuals (17). This is projected to cut the number of deceased-donor renal transplants by 18% for candidates aged and by 33% for those aged 65 and older over a year compared to allocation based on current rules ( optn.transplant.hrsa.gov/kars.asp, Reports to the Board of Directors, June 17, 2009). Yet the proportion of candidates listed for kidney transplantation in these two age groups have increased faster than all younger age groups over recent years accounting for 44% and 20% respectively, of the active list by the end of 2012 (optn.hrsa.gov, accessed December 15, 2012). Unfortunately, the assertion arising from a review of SRTR data (18) that the 5-year probability of deceased-donor transplantation of patients aged 65 years is nearly equal to the probability of death on the waiting-list highlights the poor prognosis of the elderly on dialysis. Considering recent trends in transplantation of the elderly in the context of new allocation concepts, high-kdri American Journal of Transplantation 2013; 13: kidneys, in the absence of a living donor, may be the most realistic option for transplantation of seniors. DKT is an additional option for minimizing risk. We found discard rates of donor kidneys within the top two KDRI categories were 18% and 41%, respectively. Initiatives to improve utilization of marginal kidneys are important. Before KDRI, the ECD designation was created, in part, to increase utilization. However, despite increased recovery of ECD kidneys and despite knowledge that these organs would be predicted to provide survival benefit over dialysis for appropriate recipients (18), transplant centers were using them with greater selectivity (19). Discard rates for the lowest risk ECD kidneys increased following institution of the ECD policy (20), indicating a reluctance to transplant kidneys with poor quality. There is great variability in organ quality that is not captured by the SCD/ ECD dichotomy and it remains to be seen whether the more granular depiction of donor risk provided with the KDRI designation will result in the acceptance of kidneys that would normally be discarded under the more vague ECD designation. Given that some significant donor risk factors are not captured by the index, transplant professionals may continue to accept or decline kidneys based on additional information such as anatomy, flush characteristics, histologic features and/or machine perfusion characteristics (20,21). Transplant centers that request OPOs to release kidneys for dual transplantation are sometimes met with resistance from the OPO either because the OPO personnel believe the kidneys can be placed as singles or the kidneys do not meet UNOS criteria for dual allocation. Given evidence that UNOS criteria does not adequately identify ECD kidneys that would confer a graft survival advantage if transplanted as dual (15), more discriminating allocation criteria are needed. Allocation of kidneys with KDRI >2.2 should be considered as an option for dual placement, not only because the already poor outcomes can be improved with dual transplantation, but organ utilization may also improve particularly if more efficient placement is employed. Our results are subject to the limitations inherent in observational data. Because kidney transplant recipients are often not randomly selected to receive dual kidneys, it is possible that they are in some unmeasured way systemically less (or more) healthy than those that received single kidneys. There is the possibility for residual confounding as a result of donor, recipient or transplant factors, not included in the analysis (not available in SRTR dataset), such as some donor biopsy characteristics, transplant technique, and degree of immunosuppression. Lastly, registry data are somewhat limited toward gaining an understanding of the causes of graft or patient loss; as such it is difficult to assess the direct association of failures that would be more reflective of donor risk factors, recipient characteristic or the interaction of these. We demonstrate that the lower graft survival seen with the transplantation of kidneys with KDRI >2.2 can be offset by 2439
8 Klair et al. dual kidney transplantation. Given the poor prognosis of the elderly on the waiting list and the decreasing opportunities of this demographic for transplantation from deceased donors, dual kidney transplantation of high-kdri kidneys should be considered to improve outcomes. More efficient allocation directing high-kdri kidneys to dual transplantation should be evaluated as a way to maximize kidney utilization. Acknowledgments The data reported here have been supplied by the Minneapolis Medical Research Foundation as the contractor for the Scientific Registry of Transplant Recipients (SRTR). The interpretation and reporting of these data are the responsibility of the author(s) and in no way should be seen as an official policy of or interpretation by the SRTR or the US Government. Disclosure The authors of this manuscript have no conflicts of interest to disclose as described by the American Journal of Transplantation. References 1. Brenner BM, Milford EL. Nephron underdosing: A programmed cause of chronic renal allograft failure. Am J Kidney Dis 1993; 5: Mackenzie HS, Azuma H, Rennke HG, Tilney NL, Brenner BM. Renal mass as a determinant of late allograft outcome: Insights from experimental studies in rats. Kidney Int Suppl 1995; 52: S38 S Moore PS, Farney AC, Sundberg AK, et al. Experience with dual kidney transplants from donors at extremes of age. Surgery 2006; 140: Lu AD, Carter JT, Weinstein RJ, et al. Outcome in recipients of dual kidney transplants: An analysis of the dual registry patients. Transplantation 2000; 69: Boggi U, Barsotti M, Collini A, et al. Kidney transplantation from donors aged 65 years or more as single or dual grafts. Transplant Proc 2005; 37: Alfrey EJ, Boissy AR, Lerner SM. Dual-kidney transplants: Longterm results. Transplantation 2003: Tan JC, Alfrey EJ, Dafoe DC, et al. Dual-kidney transplantation with organs from expanded criteria donors: A long-term follow-up. Transplantation 2004; 78: Andres A, Herrero JC, Praga M, et al. Double kidney transplant (DUAL) with kidneys from older donors and suboptimal nephron mass. Transplant Proc 2001; 33: Dietl KH, Wolters H, Marschall B, Senninger N, Heidenreich S. Cadaveric two-in-one kidney transplantation from marginal donors: Experience of 26 cases after 3 years. Transplantation 2000; 70: Remuzzi G, Ruggenenti P. Renal transplantation: Single or dual for donors aging 60 years? Transplantation 2000; 69: Ruggenenti P, Perico N, Remuzzi G. Ways to boost kidney transplant viability: A real need for the best use of older donors. Am J Transplant 2006; 6: Snanoudj R, Ranant M, Timsit MO, et al. Donor-estimated GFR as an appropriate criterion for allocation of ECD kidneys into single or dual kidney transplantation. Am J Transplant 2009; 9: Ekser B, Furian L, Broggiato A, et al. Technical aspects of unilateral dual kidney transplantation from expanded criteria donors: Experience of 100 patients. Am J Transplant 2010; 10: Remuzzi G, Cravedi P, Perna A, et al. Long-term outcome of renal transplantation from older donors. NEJM 2006; 354: Gill J, Cho YW, Danovitch GM, et al. Outcomes of dual adult kidney transplants in the United States: An analysis of the OPTN/UNOS database. Transplantation 2008; 85: Rao PS, Schaubel DE, Guidinger MK, et al. A comprehensive risk quantification score for deceased donor kidneys: The kidney donor risk index. Transplantation 2009; 88: Tso PL, Dar WA, Henry WL. With respect to elderly patients: Finding kidneys in the context of new allocation concepts. Am J Transplant 2012; 12: Schold J, Srinivas TR, Sehgal AR, Meier-Kriesche HU. Half of kidney transplant candidates who are older than 60 years now placed on the waiting list will die before receiving a deceaseddonor transplant. Clin J Am Soc Nephrol 2009; 4: Hirth RA, Pan Q, Schaubel DE, Merion RM. Efficient utilization of the expanded criteria donor (ECD) deceased donor kidney pool: An analysis of the effect of labeling. Am J Transplant 2010; 10: Sung RS, Christensen LL, Leichtman AB, et al. Determinants of discard of expanded criteria donor kidneys: Impact of biopsy and machine perfusion. Am J Transplant 2008; 8: Sokolich J, Magliocca J, Kayler LK. Import kidney offers and DonorNet: A view from the trenches. Clin Transplant 2010; 25: American Journal of Transplantation 2013; 13:
Quantification of the Early Risk of Death in Elderly Kidney Transplant Recipients
Wiley Periodicals Inc. C Copyright 2012 The American Society of Transplantation and the American Society of Transplant Surgeons Quantification of the Early Risk of Death in Elderly Kidney Transplant Recipients
More informationThe New Kidney Allocation System: What You Need to Know. Anup Patel, MD Clinical Director Renal and Pancreas Transplant Division Barnabas Health
The New Kidney Allocation System: What You Need to Know Anup Patel, MD Clinical Director Renal and Pancreas Transplant Division Barnabas Health ~6% of patients die each year on the deceased donor waiting
More informationDeterminants of Discard of Expanded Criteria Donor Kidneys: Impact of Biopsy and Machine Perfusion
American Journal of Transplantation 2008; 8: 783 792 Blackwell Munksgaard C 2008 The Authors Journal compilation C 2008 The American Society of Transplantation and the American Society of Transplant Surgeons
More informationDonor Quality Assessment
Donor Quality Assessment Francesc Moreso, MD, PhD Renal Transplant Unit Hospital Universitari Vall d Hebron Barcelona. Spain 4/9/2017 Donor Quality Assessment 1 What is the problem? Across all age ranges,
More informationPredictors of cardiac allograft vasculopathy in pediatric heart transplant recipients
Pediatr Transplantation 2013: 17: 436 440 2013 John Wiley & Sons A/S. Pediatric Transplantation DOI: 10.1111/petr.12095 Predictors of cardiac allograft vasculopathy in pediatric heart transplant recipients
More informationKidney Transplant in the Elderly. Robert Santella, M.D., F.A.C.P.
Kidney Transplant in the Elderly! Robert Santella, M.D., F.A.C.P. Incident Rate of ESRD by Age Age 75+ 65-74 From US Renal Data System, 2012 Should there be an age limit? Various guidelines: Canadian,
More informationAre two better than one?
Are two better than one? Disclosures Ryutaro Hirose, MD Professor in Clinical Surgery University of California, San Francisco I have no relevant disclosures related to this presentation The PROBLEM There
More informationDonor and Recipient Age and the Allocation of Deceased Donor Kidneys for Transplantation
Donor and Recipient Age and the Allocation of Deceased Donor Kidneys for Transplantation July 26, 2006 Donor and Recipient Age and the Allocation of Deceased Donor Kidneys for Transplantation A paper prepared
More informationKidney Transplant Outcomes In Elderly Patients. Simin Goral MD University of Pennsylvania Medical Center Philadelphia, Pennsylvania
Kidney Transplant Outcomes In Elderly Patients Simin Goral MD University of Pennsylvania Medical Center Philadelphia, Pennsylvania Case Discussion 70 year old Asian male, neuropsychiatrist, works full
More informationAccess and Outcomes Among Minority Transplant Patients, , with a Focus on Determinants of Kidney Graft Survival
American Journal of Transplantation 2010; 10 (Part 2): 1090 1107 Wiley Periodicals Inc. Special Feature No claim to original US government works Journal compilation C 2010 The American Society of Transplantation
More informationScores in kidney transplantation: How can we use them?
Scores in kidney transplantation: How can we use them? Actualités Néphrologiques 2017 M Hazzan (Lille France ) Contents Scores to estimate the quality of the graft Scores to estimate old candidates to
More informationOPTN/SRTR 2016 Annual Data Report: Preface
OPTN/SRTR 2016 Annual Data Report: Preface This Annual Data Report of the US Organ Procurement and Transplantation Network (OPTN) and the Scientific Registry of Transplant Recipients (SRTR) is the twenty-sixth
More informationObesity has become an epidemic in the United States
Original Clinical ScienceçGeneral Selected Mildly Obese Donors Can Be Used Safely in Simultaneous Pancreas and Kidney Transplantation Tarek Alhamad, MD, MS, 1,2 Andrew F. Malone, MD, 1 Krista L. Lentine,
More informationClinical correlates, outcomes and healthcare costs associated with early mechanical ventilation after kidney transplantation
The American Journal of Surgery (2013) 206, 686-692 Association of Women Surgeons: Clinical Science Clinical correlates, outcomes and healthcare costs associated with early mechanical ventilation after
More informationThe New Kidney Allocation System (KAS) Frequently Asked Questions
The New Kidney Allocation System (KAS) Frequently Asked Questions Contents General: The Need for the New System and Key Implementation Details... 4 Why was the newly revised KAS necessary?... 4 What were
More informationShould Pediatric Patients Wait for HLA-DR-Matched Renal Transplants?
American Journal of Transplantation 2008; 8: 2056 2061 Wiley Periodicals Inc. C 2008 The Authors Journal compilation C 2008 The American Society of Transplantation and the American Society of Transplant
More informationGeographic Differences in Event Rates by Model for End-Stage Liver Disease Score
American Journal of Transplantation 2006; 6: 2470 2475 Blackwell Munksgaard C 2006 The Authors Journal compilation C 2006 The American Society of Transplantation and the American Society of Transplant
More informationThe Kidney Allocation System Changed in a Substantive Way on December 5, Your Patients Have Been, and Will Be, Affected by These Changes
The Kidney Allocation System Changed in a Substantive Way on December 5, 2014 Your Patients Have Been, and Will Be, Affected by These Changes 1 The New Kidney Allocation System Terms of Importance Pediatric
More informationDoes Kidney Donor Risk Index implementation lead to the transplantation of more and higher-quality donor kidneys?
Nephrol Dial Transplant (2017) 32: 1934 1938 doi: 10.1093/ndt/gfx257 Advance Access publication 21 August 2017 Does Kidney Donor Risk Index implementation lead to the transplantation of more and higher-quality
More informationConcepts for Kidney Allocation
ORGAN PROCUREMENT AND TRANSPLANTATION NETWORK Concepts for Kidney Allocation The Organ Procurement and Transplantation Network (OPTN) is seeking feedback regarding the use of two concepts in the allocation
More informationUpdate on Kidney Allocation
Update on Kidney Allocation 23rd Annual Conference Association for Multicultural Affairs in Transplantation Silas P. Norman, M.D., M.P.H. Associate Professor Division of Nephrology September 23, 2015 Disclosures
More informationCurrent status of kidney and pancreas transplantation in the United States,
American Journal of Transplantation 25; 5 (Part 2): 94 915 Blackwell Munksgaard Blackwell Munksgaard 25 Current status of kidney and pancreas transplantation in the United States, 1994 23 Gabriel M. Danovitch
More informationPrevalence and Outcomes of Multiple-Listing for Cadaveric Kidney and Liver Transplantation
American Journal of Transplantation 24; 4: 94 1 Blackwell Munksgaard Copyright C Blackwell Munksgaard 23 doi: 1.146/j.16-6135.23.282.x Prevalence and Outcomes of Multiple-Listing for Cadaveric Kidney and
More informationTransplant Update New Kidney Allocation System Transplant Referral Strategies. Antonia Harford, MD University of New Mexico
Transplant Update New Kidney Allocation System Transplant Referral Strategies Antonia Harford, MD University of New Mexico Financial Disclosures Doctor Harford has received financial support for dialysis
More informationTransplant Nephrology Update: Focus on Outcomes and Increasing Access to Transplantation
Transplant Nephrology Update: Focus on Outcomes and Increasing Access to Transplantation Titte R Srinivas, MD, FAST Medical Director, Kidney and Pancreas Transplant Programs Objectives: Describe trends
More informationThe CARI Guidelines Caring for Australians with Renal Impairment. Assessment of donors with sub-optimal kidney function/structure GUIDELINES
Assessment of donors with sub-optimal kidney function/structure Date written: June 2004 Final submission: April 2005 GUIDELINES No recommendations possible based on Level I or II evidence SUGGESTIONS FOR
More informationKidney and Pancreas Transplantation in the United States,
American Journal of Transplantation 2006; 6 (Part 2): 1153 1169 Blackwell Munksgaard No claim to original US government works Journal compilation C 2006 The American Society of Transplantation and the
More informationArticle. Simultaneous Pancreas Kidney Transplant versus Other Kidney Transplant Options in Patients with Type 2 Diabetes
Article Simultaneous Pancreas Kidney Transplant versus Other Kidney Transplant Options in Patients with Type 2 Diabetes Alexander C. Wiseman* and Jane Gralla Summary Background and objectives Current organ
More informationTechnical Aspects of Unilateral Dual Kidney Transplantation from Expanded Criteria Donors: Experience of 100 Patients
American Journal of Transplantation 2010; 10: 2000 2007 Wiley Periodicals Inc. C 2010 The Authors Journal compilation C 2010 The American Society of Transplantation and the American Society of Transplant
More informationRenal transplantation from extended criteria cadaveric donors: problems and perspectives overview
Transplant International ISSN 0934-0874 REVIEW Renal transplantation from extended criteria cadaveric donors: problems and perspectives overview Vincent Audard, Marie Matignon, Karine Dahan, Philippe Lang
More informationThe New Kidney Allocation Policy: Implications for Your Patients and Your Practice
The New Kidney Allocation Policy: Implications for Your Patients and Your Practice Clinical Practice Today CME Co-provided by Learning Objectives Upon completion, participants should be able to: Explain
More informationChapter 6: Transplantation
Chapter 6: Transplantation Introduction During calendar year 2012, 17,305 kidney transplants, including kidney-alone and kidney plus at least one additional organ, were performed in the United States.
More informationReceiving a Kidney Transplant in the Ninth Decade of Life
Trends Edmund in Transplant. Huang and 2011;5:121-7 Suphamai Bunnapradist: Receiving a Kidney Transplant in the Ninth Decade of Life Receiving a Kidney Transplant in the Ninth Decade of Life Edmund Huang
More informationLong-Term Renal Allograft Survival in the United States: A Critical Reappraisal
American Journal of Transplantation 2011; 11: 450 462 Wiley Periodicals Inc. C 2010 The Authors Journal compilation C 2010 The American Society of Transplantation and the American Society of Transplant
More informationShipping living donor kidneys and transplant recipient outcomes
Received: 8 June 2017 Revised: 20 October 2017 Accepted: 13 November 2017 DOI: 10.1111/ajt.14597 ORIGINAL ARTICLE Shipping living donor kidneys and transplant recipient outcomes Eric Treat 1 Eric K. H.
More informationTransplant Options for Patients: Choices and Consequences. Olwyn Johnston Medical Director Kidney Transplantation Vancouver General Hospital
Transplant Options for Patients: Choices and Consequences Olwyn Johnston Medical Director Kidney Transplantation Vancouver General Hospital BC Kidney Days October 6 th 2017 Non contributory Conflict of
More informationRenal Transplantation: Allocation challenges and changes. Renal Transplantation. The Numbers 1/13/2014
Renal Transplantation: Allocation challenges and changes Mark R. Wakefield, M.D., F.A.C.S. Associate Professor of Surgery/Urology Director Renal Transplantation Renal Transplantation Objectives: Understand
More informationJ Am Soc Nephrol 14: , 2003
J Am Soc Nephrol 14: 208 213, 2003 Kidney Allograft and Patient Survival in Type I Diabetic Recipients of Cadaveric Kidney Alone Versus Simultaneous Pancreas/Kidney Transplants: A Multivariate Analysis
More informationIncidence of Rejection in Renal Transplant Surgery in the LVHN Population Leading to Graft Failure: 6 Year Review
Incidence of Rejection in Renal Transplant Surgery in the LVHN Population Leading to Graft Failure: 6 Year Review Jessica Ludolph 1 Lynsey Biondi, MD 1,2 and Michael Moritz, MD 1,2 1 Department of Surgery,
More informationCOMPARISON OF THE SURVIVAL OF SHIPPED AND LOCALLY TRANSPLANTED CADAVERIC RENAL ALLOGRAFTS
COMPARISON OF THE SURVIVAL OF SHIPPED AND LOCALLY TRANSPLANTED CADAVERIC RENAL ALLOGRAFTS A COMPARISON OF THE SURVIVAL OF SHIPPED AND LOCALLY TRANSPLANTED CADAVERIC RENAL ALLOGRAFTS KEVIN C. MANGE, M.D.,
More informationORIGINAL ARTICLE. Eric F. Martin, 1 Jonathan Huang, 3 Qun Xiang, 2 John P. Klein, 2 Jasmohan Bajaj, 4 and Kia Saeian 1
LIVER TRANSPLANTATION 18:914 929, 2012 ORIGINAL ARTICLE Recipient Survival and Graft Survival are Not Diminished by Simultaneous Liver-Kidney Transplantation: An Analysis of the United Network for Organ
More informationHome Hemodialysis or Transplantation of the Treatment of Choice for Elderly?
Home Hemodialysis or Transplantation of the Treatment of Choice for Elderly? Miklos Z Molnar, MD, PhD, FEBTM, FERA, FASN Associate Professor of Medicine Division of Nephrology, Department of Medicine University
More informationChronic renal histological changes at implantation and subsequent deceased donor kidney transplant outcomes: a single-centre analysis
Chronic renal histological changes at implantation and subsequent deceased donor kidney transplant outcomes: a single-centre analysis Benedict Phillips 1, Kerem Atalar 1, Hannah Wilkinson 1, Nicos Kessaris
More informationKidney Transplant Outcomes for Prolonged Cold Ischemic Times in the Context of Kidney Paired Donation
Kidney Transplant Outcomes for Prolonged Cold Ischemic Times in the Context of Kidney Paired Donation by Yayuk Joffres Thesis Submitted in Partial Fulfillment of the Requirements for the Degree of Master
More informationImplications of the Statewide Sharing Variance on Kidney Transplantation Geographic Inequity and Allocation Efficiency
Implications of the Statewide Sharing Variance on Kidney Transplantation Geographic Inequity and Allocation Efficiency Ashley E Davis 1, 2, Sanjay Mehrotra 1, 2, 3, Lisa McElroy 2,4, John J Friedewald
More informationLiterature Review Transplantation
Literature Review 2010- Transplantation Alexander Wiseman, M.D. Associate Professor, Division of Renal Diseases and Hypertension Medical Director, Kidney and Pancreas Transplant Programs University of
More informationReview Article: In-Depth Topic. Am J Nephrol 2003;23: DOI: /
American Journal of Nephrology Review Article: In-Depth Topic Am J Nephrol 2003;23:245 259 DOI: 10.1159/000072055 Received: May 6, 2003 Accepted: May 27, 2003 Published online: July 1, 2003 Tackling the
More informationThe time interval between kidney and pancreas transplantation and the clinical outcomes of pancreas after kidney transplantation
Clin Transplant 2012: 26: 403 410 DOI: 10.1111/j.1399-0012.2011.01519.x ª 2011 John Wiley & Sons A/S. The time interval between kidney and pancreas transplantation and the clinical outcomes of pancreas
More informationInfluence of kidney offer acceptance behavior on metrics of allocation efficiency
Accepted: 11 July 2017 DOI: 10.1111/ctr.13057 ORIGINAL ARTICLE Influence of kidney offer acceptance behavior on metrics of allocation efficiency Andrew Wey 1 Nicholas Salkowski 1 Bertram L. Kasiske 1,2
More informationkidney OPTN/SRTR 2012 Annual Data Report:
kidney wait list 18 deceased donation 22 live donation 24 transplant 26 donor-recipient matching 28 outcomes 3 pediatric transplant 33 Medicare data 4 transplant center maps 43 A. J. Matas1,2, J. M. Smith1,3,
More informationThe New Kidney Allocation System: What You Need to Know. Quality Insights Renal Network 3 Annual Meeting October 2, 2014
The New Kidney Allocation System: What You Need to Know Quality Insights Renal Network 3 Annual Meeting October 2, 2014 Pre Dialysis Era Dialysis Status in USA 500,000 patients on dialysis in 2013 100,000
More informationPancreas After Islet Transplantation: A First Report of the International Pancreas Transplant Registry
American Journal of Transplantation 2016; 16: 688 693 Wiley Periodicals Inc. Brief Communication Copyright 2015 The American Society of Transplantation and the American Society of Transplant Surgeons doi:
More informationUK Liver Transplant Audit
November 2012 UK Liver Transplant Audit In patients who received a Liver Transplant between 1 st March 1994 and 31 st March 2012 ANNUAL REPORT Advisory Group for National Specialised Services Prepared
More informationAnswers to Your Questions about a Change in Kidney Allocation Policy What you need to know
Answers to Your Questions about a Change in Kidney Allocation Policy What you need to know Who are UNOS and the OPTN? The United Network for Organ Sharing (UNOS) is a nonprofit organization that operates
More informationDeveloping a Kidney Waiting List Calculator
Developing a Kidney Waiting List Calculator Jon J. Snyder, PhD* Nicholas Salkowski, PhD, Jiannong Liu, PhD, Kenneth Lamb, PhD, Bryn Thompson, MPH, Ajay Israni, MD, MS, and Bertram Kasiske, MD, FACP *Presenter
More informationKIDNEY TRANSPLANTATION IS THE
ORIGINAL CONTRIBUTION Deceased-Donor Characteristics and the Survival Benefit of Kidney Transplantation Robert M. Merion, MD Valarie B. Ashby, MA Robert A. Wolfe, PhD Dale A. Distant, MD Tempie E. Hulbert-Shearon,
More informationHasan Fattah 3/19/2013
Hasan Fattah 3/19/2013 AASK trial Rational: HTN is a leading cause of (ESRD) in the US, with no known treatment to prevent progressive declines leading to ESRD. Objective: To compare the effects of 2 levels
More informationKidney transplantation is the treatment of choice
SPECIAL ARTICLES Evidence-based Organ Allocation* Stefanos A. Zenios, PhD, Lawrence M. Wein, PhD, Glenn M. Chertow, MD, MPH BACKGROUND: There are not enough cadaveric kidneys to meet the demands of transplant
More informationBK virus infection in renal transplant recipients: single centre experience. Dr Wong Lok Yan Ivy
BK virus infection in renal transplant recipients: single centre experience Dr Wong Lok Yan Ivy Background BK virus nephropathy (BKVN) has emerged as an important cause of renal graft dysfunction in recent
More informationKidney and Pancreas Transplantation in the United States, : Access for Patients with Diabetes and End-Stage Renal Disease
American Journal of Transplantation 29; 9 (Part 2): 894 96 Wiley Periodicals Inc. No claim to original US government works Journal compilation C 29 The American Society of Transplantation and the American
More informationThe Art and Science of Increasing Authorization to Donation
The Art and Science of Increasing Authorization to Donation OPO Metrics: The Good, The Bad, and The Maybe Charlotte Arrington, MPH Arbor Research Collaborative for Health Alan Leichtman, MD University
More informationPediatric Kidney Transplantation
Pediatric Kidney Transplantation Vikas Dharnidharka, MD, MPH Associate Professor Division of Pediatric Nephrology Conflict of Interest Disclosure Vikas Dharnidharka, MD, MPH Employer: University of Florida
More informationUser Guide. A. Program Summary B. Waiting List Information C. Transplant Information
User Guide This report contains a wide range of useful information about the kidney transplant program at (FLMR). The report has three main sections: A. Program Summary B. Waiting List Information The
More informationKidney, Pancreas and Liver Allocation and Distribution
American Journal of Transplantation 2012; 12: 3191 3212 Wiley Periodicals Inc. Special Article C Copyright 2012 The American Society of Transplantation and the American Society of Transplant Surgeons doi:
More informationLiver Transplantation for Alcoholic Liver Disease in the United States: 1988 to 1995
Liver Transplantation for Alcoholic Liver Disease in the United States: 1988 to 1995 Steven H. Belle, Kimberly C. Beringer, and Katherine M. Detre T he Scientific Liver Transplant Registry (LTR) was established
More informationWait List Management. John J. Friedewald, Darshika Chhabra, and Baris Ata. The US Transplant System. National Wait List
Wait List Management John J. Friedewald, Darshika Chhabra, and Baris Ata 4 Abbreviations CDC Centers for Disease Control and Prevention CPRAs Calculated panel reactive antibodies DCD Donation after cardiac
More informationAssociation of Kidney Transplantation with Survival in Patients with Long Dialysis Exposure
Article Association of Kidney Transplantation with Survival in Patients with Long Dialysis Exposure Caren Rose,* Jagbir Gill,* and John S. Gill* Abstract Background and objectives Evidence that kidney
More informationOlder Living Kidney Donors and Recipients. Charles Le University of Colorado 6/24/11
Older Living Kidney Donors and Recipients Charles Le University of Colorado 6/24/11 Clinical Scenario HPI: 60 y/o healthy AAM with h/o CKD5 on HD x 2 yrs 2/2 HTN, was evaluated in transplant clinic for
More informationWho will not benefit from a kidney transplant. Deirdre Sawinski, MD University of Pennsylvania
Who will not benefit from a kidney transplant Deirdre Sawinski, MD University of Pennsylvania Disclosures No financial disclosures relevant to this presentation. I am a transplant nephrologist and I believe
More informationNearly half of a million individuals in the United
Access to Kidney Transplantation among the Elderly in the United States: A Glass Half Full, not Half Empty Elke S. Schaeffner,* Caren Rose, and John S. Gill *Division of Nephrology, Charité University
More informationShort-term and Long-term Survival of Kidney Allograft Cure Model Analysis
TRANSPLANTATION Short-term and Long-term Survival of Kidney Allograft Cure Model Analysis Moghaddameh Mirzaee, 1 Jalal Azmandian, 2 Hojjat Zeraati, 1 Mahmood Mahmoodi, 1 Kazem Mohammad, 1 Abbas Etminan,
More informationReduced graft function (with or without dialysis) vs immediate graft function a comparison of long-term renal allograft survival
Nephrol Dial Transplant (2006) 21: 2270 2274 doi:10.1093/ndt/gfl103 Advance Access publication 22 May 2006 Original Article Reduced graft function (with or without dialysis) vs immediate graft function
More informationA Lifetime of Allograft Function with Kidneys from Older Donors
A Lifetime of Allograft Function with Kidneys from Older Donors Caren Rose,* Elke Schaeffner, Ulrich Frei, Jagbir Gill,* and John S. Gill* *Division of Nephrology, University of British Columbia, Vancouver,
More informationNew Zealand Kidney Allocation Scheme
New Zealand Kidney Allocation Scheme The New Zealand Kidney Allocation Scheme (NZKAS) has been developed to ensure that kidney allocation in NZ is performed on an equitable, accountable and transparent
More informationAge is an important predictor of kidney transplantation outcome
1663 Nephrol Dial Transplant (2012) 27: 1663 1671 doi: 10.1093/ndt/gfr524 Advance Access publication 16 September 2011 Age is an important predictor of kidney transplantation outcome Massimiliano Veroux
More informationThe Good, The Bad, The Needs: Current Prediction Methods Used in Program Specific Reports
The Good, The Bad, The Needs: Current Prediction Methods Used in Program Specific Reports Ajay K Israni, MD, MS Deputy Director, Scientific Registry of Transplant Recipients Associate Professor of Medicine,
More informationEn-Bloc Kidney Transplantation in the United States: An Analysis of United Network of Organ Sharing (UNOS) Data from 1987 to 2003
American Journal of Transplantation 2005; 5: 1513 1517 Blackwell Munksgaard Copyright C Blackwell Munksgaard 2005 doi: 10.1111/j.1600-6143.2005.00878.x En-Bloc Kidney Transplantation in the United States:
More informationCardiovascular Risk Reduction in Kidney Transplant Recipients
Cardiovascular Risk Reduction in Kidney Transplant Recipients Rainer Oberbauer R.O. AUG 2010 CV Mortality in ESRD compared to the general population R.O.2/32 Modified from Foley et al. AJKD 32 (suppl3):
More informationSELECTED ABSTRACTS. All (n) % 3-year GS 88% 82% 86% 85% 88% 80% % 3-year DC-GS 95% 87% 94% 89% 96% 80%
SELECTED ABSTRACTS The following are summaries of selected posters presented at the American Transplant Congress on May 5 9, 2007, in San Humar A, Gillingham KJ, Payne WD, et al. Review of >1000 kidney
More informationSimultaneous kidney and pancreas (SPK) transplantation
Original Clinical ScienceçGeneral A Reassessment of the Survival Advantage of Simultaneous Kidney-Pancreas Versus Kidney-Alone Transplantation Randall S. Sung, 1 Min Zhang, 2 Douglas E. Schaubel, 2 Xu
More informationJournal of the American College of Cardiology Vol. 60, No. 1, by the American College of Cardiology Foundation ISSN /$36.
Journal of the American College of Cardiology Vol. 60, No. 1, 2012 2012 by the American College of Cardiology Foundation ISSN 0735-1097/$36.00 Published by Elsevier Inc. http://dx.doi.org/10.1016/j.jacc.2012.02.031
More informationFor more information about how to cite these materials visit
Author(s): Silas P. Norman, M.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Noncommercial Share Alike 3.0 License: http://creativecommons.org/licenses/by-nc-sa/3.0/
More informationResearch Article Intermediate-Term Outcomes of Dual Adult versus Single-Kidney Transplantation: Evolution of a Surgical Technique
Transplantation Volume 2016, Article ID 2586761, 6 pages http://dx.doi.org/10.1155/2016/2586761 Research Article Intermediate-Term Outcomes of Dual Adult versus Single-Kidney Transplantation: Evolution
More informationOrgan Procurement and Transplantation Network
OPTN Organ Procurement and Transplantation Network POLICIES This document provides the policy language approved by the OPTN/UNOS Board at its meeting in June 2015 as part of the Operations and Safety Committee
More informationTransplant Center Quality Assessment Using a Continuously Updatable, Risk-Adjusted Technique (CUSUM)
American Journal of Transplantation 2006; 6: 313 323 Blackwell Munksgaard C 2005 The Authors Journal compilation C 2006 The American Society of Transplantation and the American Society of Transplant Surgeons
More informationPatient Selection and Volume in the Era Surrounding Implementation of Medicare Conditions of Participation for Transplant Programs
Health Services Research Health Research and Educational Trust DOI: 10.1111/1475-6773.12188 RESEARCH ARTICLE Patient Selection and Volume in the Era Surrounding Implementation of Medicare Conditions of
More informationFAIRNESS/EQUITY UTILITY/EFFICACY EFFICIENCY. The new kidney allocation system (KAS) what has it done? 9/26/2018. Disclosures
The new kidney allocation system (KAS) what has it done? Disclosures No financial disclosure Ryutaro Hirose, MD Professor in Clinical Surgery University of California San Francisco Objectives Describe
More informationProgress in Pediatric Kidney Transplantation
Send Orders for Reprints to reprints@benthamscience.net The Open Urology & Nephrology Journal, 214, 7, (Suppl 2: M2) 115-122 115 Progress in Pediatric Kidney Transplantation Jodi M. Smith *,1 and Vikas
More informationSurvival Outcomes Following Liver Transplantation (SOFT) Score: A Novel Method to Predict Patient Survival Following Liver Transplantation
American Journal of Transplantation 2008; 8: 2537 2546 Wiley Periodicals Inc. C 2008 The Authors Journal compilation C 2008 The American Society of Transplantation and the American Society of Transplant
More informationLong-term prognosis of BK virus-associated nephropathy in kidney transplant recipients
Original Article Kidney Res Clin Pract 37:167-173, 2018(2) pissn: 2211-9132 eissn: 2211-9140 https://doi.org/10.23876/j.krcp.2018.37.2.167 KIDNEY RESEARCH AND CLINICAL PRACTICE Long-term prognosis of BK
More informationDonor Scoring System for Cadaveric Renal Transplantation
American Journal of Transplantation 2001; 1: 162 170 Copyright C Munksgaard 2001 Munksgaard International Publishers ISSN 1600-6135 Donor Scoring System for Cadaveric Renal Transplantation Scott L. Nyberg
More informationSimultaneous Pancreas Kidney Transplantation:
Simultaneous Pancreas Kidney Transplantation: What is the added advantage, and for whom? Alexander Wiseman, M.D. Associate Professor, Division of Renal Diseases and Hypertension Medical Director, Kidney
More informationCJASN epress. Published on September 2, 2010 as doi: /CJN
CJASN epress. Published on September 2, 2010 as doi: 10.2215/CJN.02950410 An Emerging Population: Kidney Candidates Who Are Placed on the Waiting List after Liver, Heart, and Lung ation Titte R. Srinivas,*
More informationRENAL TRANSPLANTATION HAS
ORIGINAL CONTRIBUTION Arterial Hypertension and Renal Allograft Survival Kevin C. Mange, MD Borut Cizman, MD Marshall Joffe, MD, PhD Harold I. Feldman, MD, MSCE Context Several observational studies have
More informationEvaluation of 84 elderly donors in renal transplantation
Clin Transplant 2004: 18: 440 445 DOI: 10.1111/j.1399-0012.2004.00186.x Copyright ª Blackwell Munksgaard 2004 Evaluation of 84 elderly donors in renal transplantation Rigotti P, Baldan N, Valente M, Scappin
More informationTransplant International. Impact of graft implantation order on graft survival in simultaneous pancreas-kidney transplantation.
Draft Manuscript for Review Impact of graft implantation order on graft survival in simultaneous pancreas-kidney transplantation. Journal: Manuscript ID TRI-OA--0.R Manuscript Type: Original Article Date
More informationThree Sides to Allocation. ECD Extended Criteria Donor
Kidney Allocation- Optimal Use of Deceased Donors The New US System..and impact on wait list management Three Sides to Allocation Justice Peter G Stock MD, PhD Utility Efficiency Standard Criteria Donor
More informationSupplementary Appendix
Supplementary Appendix This appendix has been provided by the authors to give readers additional information about their work. Supplement to: Weintraub WS, Grau-Sepulveda MV, Weiss JM, et al. Comparative
More informationNarender Goel et al. Middletown Medical PC, Montefiore Medical Center & Albert Einstein College of Medicine, New York
Narender Goel et al. Middletown Medical PC, Montefiore Medical Center & Albert Einstein College of Medicine, New York 4th International Conference on Nephrology & Therapeutics September 14, 2015 Baltimore,
More informationProposal to Change Waiting Time Criteria for Kidney-Pancreas Candidates
Public Comment Proposal Proposal to Change Waiting Time Criteria for Kidney-Pancreas Candidates OPTN/UNOS Pancreas Transplantation Committee Prepared by: Abigail C. Fox, MPA UNOS Policy Department Contents
More information