Placental insufficiency and the fetal brain Giardi, G., Sep 2017, In : Placenta. 57, p p. Research output: Contribution to journal Article

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1 Research outputs Listing of Research outputs Pravastatin-l-arginine combination improves umbilical artery blood flow and neonatal outcomes in dichorionic twin pregnancies through an nitric oxide-dependent vasorelaxant effect Jurisic, A., Jurisic, Z., Lefkou, E., Pombo, J. & Girardi, G., 4 Jun 2018, In : VASCULAR PHARMACOLOGY. Pravastatin therapy during preeclampsia prevents long-term adverse health effects in mice Garrett, N., Pombo, J., Umpierrez, M., Clark, J. E., Simmons, M. & Girardi, G., 19 Apr 2018, In : JCI Insight. 3, 8 Pravastatin to treat and prevent preeclampsia. Preclinical and clinical studies. Girardi, G., Nov 2017, In : Journal of Reproductive Immunology. 124, p Placental insufficiency and the fetal brain Giardi, G., Sep 2017, In : Placenta. 57, p p. Of mice and women: Statins as a potential treatment to prevent preeclampsia in antiphospholipid syndrome. Girardi, G., 6 Mar 2017, In : Pregnancy Hypertension. 7, p p. Complement inhibition by hydroxychloroquine prevents placental and fetal brain abnormalities in antiphospholipid syndrome Bertolaccini, M. L., Contento, G., Lennen, R., Sanna, G., Blower, P. J., Ma, M. T., Sunassee, K. & Girardi, G., 1 Dec 2016, In : Journal of Autoimmunity. 75, p Urinary congophilia in women with hypertensive disorders of pregnancy and pre-existing proteinuria or hypertension Mccarthy, F. P., Adetoba, A., Gill, C., Bramham, K., Bertolaccini, M., Burton, G. J., Girardi, G., Seed, P. T., Poston, L. & Chappell, L. C., Oct 2016, In : American Journal of Obstetrics and Gynecology. 215, 4, p. 464.e1-464.e7 MRI-based methods to detect placental and fetal brain abnormalities in utero Girardi, G., 1 Apr 2016, In : Journal of Reproductive Immunology. 114, p p. Statins prevent cervical remodeling, myometrial contractions and preterm labor through a mechanism that involves hemoxygenase-1 and complement inhibition Gonzalez, J. M., Pedroni, S. M. A. & Girardi, G., Jun 2014, In : MOLECULAR HUMAN REPRODUCTION. 20, 6, p p. Complement inhibition and statins prevent fetal brain cortical abnormalities in a mouse model of preterm birth. Pedroni, S. M. A., Gonzalez, J. M., Wade, J., Jansen, M. A., Serio, A., Marshall, I., Lennen, R. J. & Girardi, G., Jan 2014, In : Biochimica et Biophysica Acta. 1842, 1, p p., N/A. Imaging of activated complement using ultrasmall superparamagnetic iron oxide particles (USPIO) - conjugated vectors: an in vivo in utero non-invasive method to predict placental insufficiency and abnormal fetal brain development Girardi, G., Fraser, J., Lennen, R., Vontell, R., Jansen, M. & Hutchison, G., 2014, In : Molecular Psychiatry. 10 p. Comparison of the mechanisms responsible for cervical remodeling in preterm and term labor Gonzalez, J. M., Romero, R. & Girardi, G., Mar 2013, In : Journal of Reproductive Immunology. 97, 1, p p., N/A.

2 Can statins prevent pregnancy complications? Girardi, G., 2013, In : Journal of Reproductive Immunology. N/A, N/A, p. N/A 7 p., N/A. Classical complement activation as a footprint for murine and human antiphospholipid antibody-induced fetal loss Cohen, D., Buurma, A., Goemaere, N. N., Girardi, G., le Cessie, S., Scherjon, S., Bloemenkamp, K. W. M., de Heer, E., Bruijn, J. A. & Bajema, I. M., Dec 2011, In : The Journal of Pathology. 225, 4, p p., N/A. Cervical remodeling/ripening at term and preterm delivery: the same mechanism initiated by different mediators and different effector cells Gonzalez, J. M., Dong, Z., Romero, R. & Girardi, G., 2 Nov 2011, In : PLoS ONE. 6, 11, p. N/A 8 p., e Role of complement component C1q in the onset of preeclampsia in mice Singh, J., Ahmed, A. & Girardi, G., Oct 2011, In : Hypertension. 58, 4, p p., N/A. Complement activation in animal and human pregnancies as a model for immunological recognition Girardi, G., Prohászka, Z., Bulla, R., Tedesco, F. & Scherjon, S., Aug 2011, In : Molecular Immunology. 48, 14, p p., N/A. Complement activation triggers metalloproteinases release inducing cervical remodeling and preterm birth in mice Gonzalez, J. M., Franzke, C-W., Yang, F., Romero, R. & Girardi, G., Aug 2011, In : The American journal of pathology. 179, 2, p p., N/A. Role of tissue factor in pregnancy complications: crosstalk between coagulation and inflammation Girardi, G., Feb 2011, In : Thrombosis Research. 127, Suppl 3, p. S43-S46 4 p., N/A. Antiphospholipid antibodies promote leukocyte-endothelial cell adhesion and thrombosis in mice by antagonizing enos via β2gpi and apoer2 Ramesh, S., Morrell, C. N., Tarango, C., Thomas, G. D., Yuhanna, I. S., Girardi, G., Herz, J., Urbanus, R. T., de Groot, P. G., Thorpe, P. E., Salmon, J. E., Shaul, P. W. & Mineo, C., 4 Jan 2011, In : Journal of Clinical Investigation. 121, 1, p p., N/A. Role of tissue factor in the maternal immunological attack of the embryo in the antiphospholipid syndrome Girardi, G., Dec 2010, In : Clinical reviews in allergy & immunology. 39, 3, p p. A new mouse model to explore therapies for preeclampsia Ahmed, A., Singh, J., Khan, Y., Seshan, S. V. & Girardi, G., 27 Oct 2010, In : PLoS ONE. 5, 10, p. N/A 9 p., e An alternative role of C1q in cell migration and tissue remodeling: contribution to trophoblast invasion and placental development Agostinis, C., Bulla, R., Tripodo, C., Gismondi, A., Stabile, H., Bossi, F., Guarnotta, C., Garlanda, C., De Seta, F., Spessotto, P., Santoni, A., Ghebrehiwet, B., Girardi, G. & Tedesco, F., 1 Oct 2010, In : Journal of Immunology. 185, 7, p p., N/A.

3 Pravastatin prevents miscarriages in antiphospholipid antibody-treated mice Girardi, G., Nov 2009, In : Journal of Reproductive Immunology. 82, 2, p p., N/A. Role of tissue factor in a mouse model of thrombotic microangiopathy induced by antiphospholipid antibodies Seshan, S. V., Franzke, C-W., Redecha, P., Monestier, M., Mackman, N. & Girardi, G., 20 Aug 2009, In : Blood. 114, 8, p p., N/A. Pravastatin prevents miscarriages in mice: role of tissue factor in placental and fetal injury Redecha, P., van Rooijen, N., Torry, D. & Girardi, G., 23 Apr 2009, In : Blood. 113, 17, p p., N/A. Neutrophil activation by the tissue factor/factor VIIa/PAR2 axis mediates fetal death in a mouse model of antiphospholipid syndrome Redecha, P., Franzke, C-W., Ruf, W., Mackman, N. & Girardi, G., 1 Oct 2008, In : Journal of Clinical Investigation. 118, 10, p p., N/A. Guilty as charged: all available evidence implicates complement's role in fetal demise Girardi, G., Mar 2008, In : American Journal of Reproductive Immunology. 59, 3, p p., N/A. Antiphospholipid antibodies and pregnancy loss: a disorder of inflammation Salmon, J. E. & Girardi, G., Jan 2008, In : Journal of Reproductive Immunology. 77, 1, p p., N/A. Complement inhibition keeps mothers calm and avoids fetal rejection Girardi, G., 2008, In : Immunological Investigations. 37, 5-6, p p., N/A. Tissue factor: a link between C5a and neutrophil activation in antiphospholipid antibody induced fetal injury Redecha, P., Tilley, R., Tencati, M., Salmon, J. E., Kirchhofer, D., Mackman, N. & Girardi, G., 1 Oct 2007, In : Blood. 110, 7, p p., N/A. Fetal gene defects precipitate platelet-mediated pregnancy failure in factor V Leiden mothers Sood, R., Zogg, M., Westrick, R. J., Guo, Y-H., Kerschen, E. J., Girardi, G., Salmon, J. E., Coughlin, S. R. & Weiler, H., 14 May 2007, In : Journal of Experimental Medicine. 204, 5, p p., N/A. The antiphospholipid syndrome as a disorder initiated by inflammation: implications for the therapy of pregnant patients Salmon, J. E., Girardi, G. & Lockshin, M. D., Mar 2007, In : NATURE CLINICAL PRACTICE RHEUMATOLOGY. 3, 3, p ; quiz 1 p following p., N/A. Theodore E. Woodward Award: antiphospholipid syndrome revisited: a disorder initiated by inflammation Salmon, J. E. & Girardi, G., 2007, In : Transactions of the American Clinical and Climatological Association. 118, p p. Complement activation induces dysregulation of angiogenic factors and causes fetal rejection and growth restriction Girardi, G., Yarilin, D., Thurman, J. M., Holers, V. M. & Salmon, J. E., 4 Sep 2006, In : Journal of Experimental Medicine. 203, 9, p p., N/A.

4 The complement system in the pathophysiology of pregnancy Girardi, G., Bulla, R., Salmon, J. E. & Tedesco, F., Jan 2006, In : Molecular Immunology. 43, 1-2, p p. Requirement of activation of complement C3 and C5 for antiphospholipid antibody-mediated thrombophilia Pierangeli, S. S., Girardi, G., Vega-Ostertag, M., Liu, X., Espinola, R. G. & Salmon, J., Jul 2005, In : Arthritis & Rheumatism. 52, 7, p p. Complement activation: a novel pathogenic mechanism in the antiphospholipid syndrome Pierangeli, S. S., Vega-Ostertag, M., Liu, X. & Girardi, G., Jun 2005, In : Annals of the New York Academy of Sciences. 1051, N/A, p p., N/A. Heparin treatment in pregnancy loss: Potential therapeutic benefits beyond anticoagulation Girardi, G., Jun 2005, In : Journal of Reproductive Immunology. 66, 1, p p. TNF-alpha is a critical effector and a target for therapy in antiphospholipid antibody-induced pregnancy loss Berman, J., Girardi, G. & Salmon, J. E., 1 Jan 2005, In : Journal of Immunology. 174, 1, p p. A novel inhibitor of the alternative complement pathway prevents antiphospholipid antibody-induced pregnancy loss in mice Thurman, J. M., Kraus, D. M., Girardi, G., Hourcade, D., Kang, H. J., Royer, P. A., Mitchell, L. M., Giclas, P. C., Salmon, J., Gilkeson, G. & Holers, V. M., Jan 2005, In : Molecular Immunology. 42, 1, p p., N/A. Anti-phospholipid antibodies restore mesenteric ischemia/reperfusion-induced injury in complement receptor 2/complement receptor 1-deficient mice Fleming, S. D., Egan, R. P., Chai, C., Girardi, G., Holers, V. M., Salmon, J., Monestier, M. & Tsokos, G. C., 1 Dec 2004, In : Journal of Immunology. 173, 11, p p., N/A. Heparin prevents antiphospholipid antibody-induced fetal loss by inhibiting complement activation Girardi, G., Redecha, P. & Salmon, J. E., Nov 2004, In : Nature Medicine. 10, 11, p p. The role of complement in the antiphospholipid syndrome Salmon, J. E. & Girardi, G., 2004, In : Current directions in autoimmunity. 7, p p. Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome Girardi, G., Berman, J., Redecha, P., Spruce, L., Thurman, J. M., Kraus, D., Hollmann, T. J., Casali, P., Caroll, M. C., Wetsel, R. A., Lambris, J. D., Holers, V. M. & Salmon, J. E., Dec 2003, In : Journal of Clinical Investigation. 112, 11, p p., N/A. The role of complement in pregnancy and fetal loss Girardi, G. & Salmon, J. B., Feb 2003, In : Autoimmunity. 36, 1, p p. Complement C3 activation is required for antiphospholipid antibody-induced fetal loss Holers, V. M., Girardi, G., Mo, L., Guthridge, J. M., Molina, H., Pierangeli, S. S., Espinola, R., Xiaowei, L. E., Mao, D., Vialpando, C. G. & Salmon, J. E., 21 Jan 2002, In : Journal of Experimental Medicine. 195, 2, p p., N/A.

5 The above report is produced using the following setup Ordered by: null