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1 Supplementary appendix This appendix formed part of the original submission and has been peer reviewed. We post it as supplied by the authors. Supplement to: Geltrude Mingrone, Stefan Bornstein, Carel W Le Roux. Optimisation of follow-up after metabolic surgery. Lancet Diabetes Endocrinol 2017; published online Jan 26.
2 The strings used in our PbMed/Medline search were complications [mh] or complications [tiab] randomized controlled trial [mh] or randomized controlled trial [tiab] randomized trial [mh] or randomized trial [tiab] long term complications [mh] or medical complications [tiab] long term complications [mh] or medical complications [tiab] 1
3 pre surgery assessment protocol [mh] or pre surgery assessment protocol [tiab] before surgery exam [mh] or before surgery exam [tiab] pre surgery assessment protocol [mh] or pre surgery assessment protocol [tiab] polysomnography [mh] polysomnography [tiab] endoscopy [mh] or endoscopy [tiab] 2
4 echocardiogram [mh] or echocardiogram [tiab] stress test [mh] or stress test [tiab] polysomnography [mh] or plysomnography [tiab] vitamins [mh] or vitamins [tiab] oligoelements [mh] or oligoelements [tiab] 3
5 weight regain [mh] or weight regain [tiab] insufficient weight loss [mh] or insufficient weight loss [tiab] hypoglycemia [mh] or hypoglycemia [tiab] kidney stone [mh] or kidney stone [tiab] The only filter used was for the English language. 4
6 Reference Type of Operation Number of Pts Iron deficien cy (%) Folate deficienc y (%) Vitami n B12 deficien cy (%) Anaemia (%) Lyposoluble Vitamin s Deficien cy (%) Albumi n Deficie ncy (%) Calciu m Deficie ncy (%) Halverson et al. (1981) Amaral et al (1985) Brolin et al. (1998) Skroubis G et al. (2002) Koffman BM et al. (2006) Marcuard SP et al.() Vargas-Ruiz et al. (2008) RYGB RYGB RYGB RYGB RYGB RYGB RYGB Ruz M et al. RYGB
7 (2009) Brolin RE et al (1999) Dalcanale L. et al.(2010) Van Rutte et al. (2014) Alexandrou et al. RYGB RYGB RYGB Vit D3 81 RYGB Vit D3 89 (2014) Alexandrou et al. SG (2014) Ben-Porat T (2017) Brolin RE et al (1999) SG BPD Scopinaro N. et al. (1998) BPD night blindne ss - - Skroubis G BPD
8 et al. (2002) Dolan K et al. (2004) De Luis DA et al. (2005) Biertho L et al (2010) Gracia JA et al. (2009) BPD BPD BPD BPD Slater GH et al. (2004) BPD/Duod enal Switch Vit. A Vit. K 68 Vit. D 63 Bolckmans & Himpens (2016) BPD/Duod enal Switch in women 60 in men Vit D 77% 2.9 Ballestreros et al. (2016) BPD/Duod enal Switch Vit D
9 REFERENCES Halverson JD, Zuckerman, GR Koheler RE, et al. Gastric bypass for morbid obesity. A medical surgical assessment. Ann Surg. 1981;194: Amaral JF, Thompson WR, Caldwell MD, et al. Prospective hematologic evaluation of gastric exclusion surgery for morbid obesity. Ann Surg. 1985;201: Brolin RE, Gorman JH, Gorman RC, Petschenik AJ, Bradley LJ, Kenler HA, Cody RP. Are vitamin B12 and folate deficiency clinically important after roux-en-y gastric bypass? J Gastrointest Surg. 1998;2: Skroubis G, Sakellaropoulos G, Pouggouras K, Mead N, Nikiforidis G, Kalfarentzos F. Comparison of nutritional deficiencies after Roux-en-Y gastric bypass and after biliopancreatic diversion with Roux-en-Y gastric bypass. Obes Surg. 2002;12:551-8 Koffman BM, Greenfield LJ, Ali II, Pirzada NA. Neurologic complications after surgery for obesity. Muscle Nerve. 2006;33: Marcuard SP, Sinar DR, Swanson MS, Silverman JF, Levine JS 1989 Absence of luminal intrinsic factor after gastric bypass surgery for morbid obesity. Dig Dis Sci 34: Vargas-Ruiz AG, Hernández-Rivera G, Herrera MF. Prevalence of iron, folate, and vitamin B12 deficiency anemia after laparoscopic Roux-en-Y gastric bypass. Obes Surg. 2008;18: Ruz M, Carrasco F, Rojas P, Codoceo J, Inostroza J, Rebolledo A, Basfi-fer K, Csendes A, Papapietro K, Pizarro F, Olivares M, Sian L, Westcott JL, Hambidge KM, Krebs NF. Iron absorption and iron status are reduced after Roux-en-Y gastric bypass. Am J Clin Nutr. 2009;90: Dalcanale L, Oliveira CP, Faintuch J, Nogueira MA, Rondó P, Lima VM, Mendonça S, Pajecki D, Mancini M, Carrilho FJ. Long-term nutritional outcome after gastric bypass. Obes Surg. 2010; 20:181-7 Brolin RE, Leung M. Survey of vitamin and mineral supplementation after gastric bypass and biliopancreatic diversion for morbid obesity. Obes Surg. 1999;9:
10 Scopinaro N, Adami GF, Marinari GM, Gianetta E, Traverso E, Friedman D, Camerini G, Baschieri G, Simonelli A. Biliopancreatic diversion. World J Surg. 1998;22: Dolan K, Hatzifotis M, Newbury L, Lowe N, Fielding G. A clinical and nutritional comparison of biliopancreatic diversion with and without duodenal switch. Ann Surg. 2004;240:51-6 de Luis DA, Pacheco D, Izaola O, Romero A, Marcos JL, Pelaz J, Barrera A, Cabezas G, Terroba MC, Cuellar L, Anta A. Early clinical and surgical results of biliopancreatic diversion. Obes Surg. 2005;15: Biertho L, Biron S, Hould FS, Lebel S, Marceau S, Marceau P. Is biliopancreatic diversion with duodenal switch indicated for patients with body mass index <50 kg/m2? Surg Obes Relat Dis. 2010;6: Gracia JA, Martínez M, Elia M, Aguilella V, Royo P, Jiménez A, Bielsa MA, Arribas D. Obesity surgery results depending on technique performed: long-term outcome. Obes Surg. 2009;19: Slater GH, Ren CJ, Siegel N, Williams T, Barr D, Wolfe B, Dolan K, Fielding GA. Serum fatsoluble vitamin deficiency and abnormal calcium metabolism after malabsorptive bariatric surgery. J Gastrointest Surg. 2004;8:
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