BIBLIOGRAFIA. ANDERSON, G.D. (1998) - A mechanistic approach to antiepileptic drug interactions. Ann. Pharmacother. 32 (1998)

Size: px
Start display at page:

Download "BIBLIOGRAFIA. ANDERSON, G.D. (1998) - A mechanistic approach to antiepileptic drug interactions. Ann. Pharmacother. 32 (1998)"

Transcription

1 VII. BIBLIOGRAFIA

2 148

3 BIBLIOGRAFIA ANDERSON, G.D. (1998) - A mechanistic approach to antiepileptic drug interactions. Ann. Pharmacother. 32 (1998) BENES, J. [et al.] (1999) - Anticonvulsant and Sodium Channel-Blocking Properties of Novel 10,11-Dihydro-5H-dibenz[b,f]azepine-5-carboxamide Derivatives. J. Med. Chem. 42 (1999) BERTRAND, P.; DUBAS, F. (1990) - Épilepsies: étiologie, diagnostic, évolution, pronostic et principes du traitement. Nouv. Quest. 2:6 (1990) BESAG, F.M.C. [et al.] (1998) Carbamazepine toxicity with Lamotrigine: pharmacokinetic or pharmacodynamic interaction? Epilepsia. 39:2 (1998) BIALER, M. (1993) - Comparative pharmacokinetics of the newer antiepileptic drugs. Epilepsy Res. 24:6 (1993) BIALER, M. (2002) - New Antiepileptic Drugs Currently in Clinical Trials: Is There a Strategy in Their Development? Ther. Drug Monit. 24 (2002) BIALER, M. [et al.] (2002) - Progress report on new antiepileptic drugs : a summary of the Sixth Eilat Conference (EILAT VI). Epilepsy Res. 51 (2002) BLAISE, F.D.; BOURGEOIS, M.D. (2000) - Pharmacokinetic properties of current antiepileptic drugs: what improvements are needed? Neurology. 55: suppl. 3 (2000) S11-S16. BOROWICZ, KK. [et al.] (2000) - Low propensity of conventional antiepileptic drugs for interaction with felbamate against maximal electroshock-induced seizures in mice. J. Neural. Transm. 107 (2000) BOROWICZ, K.K. [et al.] (2002) - Effect of Gabapentin on the Anticonvulsivant Activity Of Antiepileptic Drugs against Electroconvulsions in Mice: An Isobolographic Analysis. Epilepsia. 43:Suppl. 9 (2002) VII. BIBLIOGRAFIA 149

4 BRODIE, M.J. (2001) Do we need any more antiepileptic drugs? Epilepsy Res. 45 (2001) 3-6. BURSTEIN, A.H. (1995) - Evaluation of new drugs: Lamotrigine. Pharmacotherapy. 15:2 (1995) CASTEL-BRANCO, M.M. [et al.] (2003) - Anticonvulsant profile of lamotrigine in rats following a single intraperitoneal dose. J. Veterinary Pharmacol. Ther. Aug. 26:Suppl. 1 (2003) CASTEL BRANCO, M.M. (2002) - Caracterização neurofarmacocinética da lamotrigina em ratos. Coimbra. Laboratório de Farmacologia; Faculdade de Farmácia, Universidade de Coimbra, 2003.Tese de doutoramento. CLEMENS, B.; MÉNES, A.; NAGY, Z. (2004) Objective assessment of neurotoxicity while shifting from carbamazepine to oxcarbazepine. Acta Neurol. Scand. 109 (2004) CZUCZWAR, S.J.; BOROWICZ K.K. (2002) Polytherapy in epilepsy: the experimental evidence. Epilepsy Res. 52 (2002) DALBY, N.O.; NIELSON, E.B. (1997) - Comparison of the preclinical anticonvulsant profiles of Tiagabine, Lamotrigine, Gabapentin and Vigabatrin. Epilepsy Res. 28 (1997) DE SARRO, G. [et al.] (2001) - Influence or retigabine on the anticonvulsant activity of some antiepileptic drugs against audiogenic seizures in DBA/2 mice. Nauny-Schmiedeberg s Arch. Pharmacol. 363 (2001) DECKERS, C.L.P. [et al.] (2000) - Selection of antiepileptic drug polytherapy based on mechanisms of action: the evidence reviewd. Nov. 41:11 Epilepsia. (2000) DECKERS, C.L.P. [et al.] (2002) - Current limitations of antiepileptic drug therapy: a conference review. Epilepsy Res. 53 (2002)

5 DIAS, M.S. (1992) Epilepsia: Considerações sobre a doença e o seu tratamento. Farmácia Port.76:7/8(1992) DICHTER, M.A.; BRODIE, M.J. (1996) - Drug Therapy: New Antiepileptic drugs. N. Engl. J. Med. Jun. 334:24 (1996) DREIFUSS, F.E. (1997) - Classification of Epileptic Seizures. In ENGEL, J.; PEDLEY, T.A. ed. lit. - Epilepsy: A Comprehensive Textbook. Philadelphia: Lippincott-Raven Publishers, Raven Publishers, Vol. 1, chapter 44 (1997) ELWES, R.D.C.; BINNIE, C.D. (1996) - Clinical Pharmacokinetics of Newer Antiepileptic Drugs: Lamotrigine, Vigabatrin; Gabapentin and Oxcarbazepine. Clin. Pharmacokinet. Jun. 30:6 (1996) ENGEL, J.J.; PEDLEY, T.A. (1997) - Introduction: What is Epilepsy? In ENGEL, J.; PEDLEY,T.A. ed. lit. - Epilepsy: A Comprehensive Textbook. Philadelphia: Lippincott-Raven Publishers. Vol. 1: Chapter 1 (1997) 1-7. ESTEVES, A.; GARRETT, C. (2001) - Antiepilépicos. In OSSWALD, W.; GUIMARÃES, S. Terapêutica Medicamentosa e suas Bases Farmacológicas. 4ªed.Porto: Porto Editora, (2001) Cap.18: p FERRENDELLI, J.A. (2001) - Concerns with antiepileptic drug initiation: safety, tolerability and efficacy. Epilepsia. 42:Suppl. 4 (2001) FERRENDELLI, J.A. (1999) - Pharmacology of Antiepileptic Drug Polypharmacy. Epilepsia. 40:Suppl. 5 (1999) S81-S83. FERRENDELLI, J.A. (1995) - Relating pharmacology to clinical practice: The pharmacologic basis of rational polypharmacy. Neurology. 45: Suppl. 2 (1995) S12-S16. FILIPE, C.N. (1997) Mecanismos básicos das epilepsias. Rev Port Pedopsiq. 12 (1997) VII. BIBLIOGRAFIA 151

6 FIRMINO, H.; MARQUES, R. (1991) - Aspectos psicossociais do Doente epiléptico. Médice. 9 (1991) FITTON, A.; GOA, K.L. (1995) - Lamotrigine. An update of its pharmacology and therapeutic use in epilepsy. Drugs. 50:4 (1995) GESSNER, P.K. (1995) - Isobolographic analysis of interactions: an update on applications and utility. Toxicology. 105 (1995) GILMAN, J.T. (1995) - Lamotrigine: an antiepileptic agent for the treatment of partial seizures. Ann. Pharmacother. 29 (1995) GIL-NAGEL, A. (2003) Review of new antiepileptic drugs as initial therapy. Epilepsia. 44 (Suppl. 4) (2003) GOA, K.L.; ROSS, S.R.; CHRISP P. (1993) - Lamotrigine: a review of its pharmacological and clinical efficacy in epilepsy. Drugs. 46:1 (1993) GOODMAN, L.S. [et al.] (1958) - Comparison of maximal seizures evoked by pentylenetetrazol (metrazol) and electroshock in mice, and their modification by anticonvulsants. J. Pharmacol. Exp. Ther. 108 (1958) GRAVES, N.M.; LEPPIK, I.E. (1991) - Antiepileptic medications in development. Ann. Pharmacother. 25 (1991) GUBERMAN, A. (1998) - Monotherapy or polytherapy for Epilepsy? Can. J. Neurol. Sci. 25:Suppl. 4 (1998) S3-S8. HACHAD, H.; RAGUENEAU-MAJLESSI, I.; LEVY, R.H. (2002) - New Antiepileptic Drugs: Review on Drug Interactions. Ther. Drug. Monit. 24:1 (2002) HULSMAN, J. A. R. J. (1995) Effects of felbamate on the pharmacokinetics of oxcarbazepine. Clin. Pharmacol. Ther. 58 (1995)

7 KALIS, M.M.; HUFF, N.A. (2001) - Oxcarbazepine, an antiepileptic agent. Clin. Ther. 23: 5 (2001) KÄLVIÄINEN, R.; KERÄNEN, T.; RIEKKINEN, SR P.J. (1993) - Place of the Newer Antiepileptic Drugs in the Tratment of epilepsy. Drugs. 46:6 (1993) KUBOVA, H.; MARES, P. (1993) - Anticonvulsant action of Oxcarbazepine, Hydroxycarbazepine, and Carbazepine against metrazol-induced motor seizures in developing rats. Epilepsia. 34:1 (1993) KWAN, P.; BRODIE, M.J. (2000) Epilepsy after the first drug fails: substitution or add-on? 9 Epilepsy Quarterly. (2000) KWAN, P. (2001) - Management of Patients with Newly Diagnosed Epilepsy. Epilepsy Quarterly. 9:2 (2001) LAFFAN, R.J.; SWINYARD, E.A.; GOODMAN, L.S. (1957) - Stimulus intensity, maximal electroshock seizures, and potency of anticonvulsants in rats. Arch. Int. Pharmacodyn. Ther. 111 (1957) LEACH, J.P. (2000) Antiepileptic drugs: safety in numbers? Seizure. 9 (2000) LEPPIK, I. E. (2000) - Monotherapy and polypharmacy. Neurology 55: Suppl. 3 (2000) S25-S29. LÖSCHER, W.; FASSBENDER, C.P,; NOLTING, B. (1991) - The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsivante drugs. II. Maximal Electroshock Seizure Models. Epilepsy Res. 8 (1991) LÖSCHER, W.; SCHMIDT, D. (1994) - Strategies in antiepileptic drug development: is rational drug design superior to random screening and structural variation? Epilepsy Res. 17 (1994) LÖSCHER, W.; SCHMIDT, D. (1998) - Which animals models should be used in the search for new antiepileptic drugs? A proposal based on experimental and clinical considerations. Epilepsy Res. 2 (1998) VII. BIBLIOGRAFIA 153

8 LÖSCHER, W. (1998) - New visions in the pharmacology of anticonvulsion. Eur. J. Pharmacol. 342 (1998) LÖSCHER, W. (2002) Current status and future directions in the pharmacotherapy of epilepsy. Trends Pharmacol. Sci. 23: 3 (2002) LÖSCHER, W,; SCHMIDT, D, (2002) New horizonts in the development of antiepileptic drugs. Epilepsy Res. 50 (2002) LOWENSTEIN, D.H. (2002) Convulsões e Epilepsia. In HARRISON,T.R..- Medicina Interna. Rio de Janeiro: Mc Graw Hill; 15ª ed., Vol II chapter 360: p LUSZCZKI, J.J. [et al.] (2003a) - Interactions Between Oxcarbazepine and Conventional Antiepileptic Drugs in the Maximal Electroshock Test in Mice: An Isobolographic Analysis. Epilepsia. 44:4 (2003a) LUSZCZKI, J.J. [et al.] (2003b) - Interactions of Lamotrigine with Topiramate and First-generation Antiepileptic Drugs in the Maximal Electroshock Test in Mice: An Isobolographic Analysis. Epilepsia. 44:8 (2003b) LUSZCZKI, J.J. [et al.] (2003c) - Interactions of Tiagabine with some antiepileptics in the maximal electroshock in mice. Pharmacol. Biochem. Behav. 75 (2003c) LUSZCZKI, J.J.; CZUCZWAR, S.J. (2003d) - Isobolographic and subthreshold methods in the detection of interactions between oxcarbazepine and conventional antiepileptics - a comparative study. Epilepsy Res. 56 (2003d) LUSZCZKI, J.J.; CZUCZWAR, S.J. (2004) - Isobolographic profile of interactions between tiagabine and gabapentin: a preclinical study. Naunyn- Schmiedeberg s Arch Pharmacol. 369 (2004) MACHADO, S.G.; ROBINSON, G.A. (1994) - A direct, general approach based on isobolograms for assessing the joint of drugs in pre-clinical experiments. Stats. Med. 13 (1994)

9 MATAR, K.M. [et al.] (1999) - Effect of valproic acid on the pharmacokinetic profile of Oxcarbazepine in the rat. Pharm. Acta Helv. 73 (1999) MAY, T.W.; KORN-MERKER, E.; RAMBECK, B. (2003) - Clinical Pharmacokinetics of Oxcarbazepine. Clin. Pharmacokinet. 42:12 (2003) MCAULEY, J. [et al.] (2002) - Newer Therapies in the Drug Treatment of Epilepsy. Ann. Pharmacother. Jan. 36 (2002) MCLEAN, M.J. (1994) - Oxcarbazepine: mechanisms of action. Epilepsia. 35: Suppl. 3 (1994) S5-S9. MILLER A.A. [et al.] (1986) - Pharmacological studies on Lamotrigine, a novel potencial antiepileptic drug: I. Anticonvulsant profile in mice and rats. Epilepsia. 27:5 (1986) MILLER, A.A. [et al.] (1986a) - Lamotrigine. In MELDRUM, B.L.; PORTER, R.J., ed. Lit. - Currents problems in epilepsy. 4-New antiepileptic drugs. London: John Libbey & Co., 1986.Chapter 12:p NATSCH, S. [et al.] (1997) - Newer Anticonvulsants Drugs: role of paharmacology, drug interactions and adverse reactions in drug choice. Drug Saf. Oct. 17:4 (1997) NOVACK, G.D.; STARK, L.G.; PETERSON,S. (1978) - Anticonvulsant effects of Bezhydryl Piperazines on Maximal Electroshock seizures in Rats. J. Pharm. Exp. Ther. 208:3 (1978) PASCHOA, O.E.D. (1997) - Seizure patterns in Kindling and Cortical Stimulation models of experimental epilepsy. Brain Res. 770 (1997) PATSALOS, P.N.; DUNCAN, J.S. (1993) - Antiepileptic Drugs: A Review of Clinically Significant Drug Interactions. Drug Saf. 9:3 (1993) PATSALOS, P.N.; SANDER, J.W.A.S. (1994) - Newer Antiepileptic Drugs: Towards an improved Risk-Benefit Ratio. Drug Saf. 11:1 (1994) VII. BIBLIOGRAFIA 155

10 PATSALOS P.N. [et al.] (2002) - The importance of drug interactions in epilepsy therapy. Epilepsia. 43:4 (2002) PELLOCK, J.M. (2000) - Treatment of Epilepsy in the New Millennium. Pharmacoterapy. 20:8 Pt. 2 (2000) 129S-138S. PERUCCA E. (2002) - Marketed new antiepileptic drugs: are they better than old-generation agents? Ther. Drug Monit. 24 (2002) PERUCCA E. (2002) Overtreatment in epilepsy: adverse consequences and mechanisms. Epilepsy Res. 52 (2002) PERUCCA E. (1995) - Pharmacological principles as a basis for polytherapy. Acta Neurol. Scand. Suppl. 162 (1995) PERUCCA E. (1996) - The New Generation Antiepileptic drugs: advantages and disadvantages. Br. J. Clin. Pharmacol. 42 (1996) Rambeck, B.; Specht, U.; Wolf, P. (1996) - Pharmacokinetic Interactions of New Antiepileptic Drugs. Clin. Pharmacokinet. Oct. 31:4 (1996) Rambeck, B.; Wolf, P. (1993) - Lamotrigine clinical pharmacokinetics. Clin. Pharmacokinet. 25:6 (1993) RATAUD, J. [et al.] (1994) - Comparative study of voltage-sensitive sodium channel blockers in focal ischaemia and electric convulsions in rodents. Neuros. Letters. 172 (1994) RIVA, R. [et al.] (1996) - Pharmacokinetic Interactions between Antiepileptic Drugs. Clin. Pharmacokinet. Dec. 31:6 (1996) ROKS, G. [et al.] (1999) - Effects of Polytherapy Compared With Monotherapy in Antiepileptics Drugs: An Animal Study. J. Pharmacol. Exp. Ther. 288 (1999) SABERS, A.; GRAM, L. (2000) - Newer Anticonvulsants: comparative review of drug interactions and adverse efects. Drugs. Jul. 60:1 (2000)

11 SMITH, P.E.M. (2001) Clinical recommendations for oxcarbazepine. Seizure. 10 (2001) SCHMIDT, D.; GRAM, L. (1995) Monotherapy versus Polytherapy in Epilepsy. CNS Drugs. 3:3 (1995) SCHMIDT, D. [et al.] (2001) Recommendations on the clinical use of oxcarbazepine in the treatment of epilepsy: a consensus view. Acta Neurol. Scand. 104 (2001) SCHMIDT, D.; ELGER, C.; HOLMES, G.L. (2002) Pharmacological overtreatment in epilepsy. Mechanisms and management. Epilepsy Res. 52 (2002a) SCHMIDT, D. (2002) Strategies to prevent overtreatment with antiepileptic drugs in patients with epilepsy. Epilepsy Res. 52 (2002b) SCHMUTZ, M. [et al.] (1994) - Oxcarbazepine: preclinical anticonvulsant profile and putative mechanisms of action. Epilepsia. 35 Suppl. 5 (1994) S SCHWABE, S. (1994) Oxcarbazepine: clinical development program. Epilepsia. 35: Suppl. 5 (1994) S51-S53. SCHWINGHAMMER, T. L.; KROBOTH P.D. (1988) Basic concepts in pharmacodynamic modelling. J. Clin. Pharmacol. 28 (1988) STEPHEN, L.J., BRODIE, M.J. (2002) Seizure freedom with more than one antiepileptic drug. Seizure. 11 (2002) STEINHOFF, B.J. [et al.] (2003) - The ideal characteristics of antiepileptic therapy: an overview of old and new AEDs. Acta Neurol. Scand. 107 (2003) SWIADER, M. [et al.] (2000) - Interaction of topiramate with conventional antiepileptic drugs in mice. Eur. J. Pharmacol. Jun. 30, 399:1 (2000) SWINYARD, E.A.; WOODHEAD, J.H.; WOLF, H.H. (1989) - Use of isobolograms in predicting drug interactions. In: PITLICK W, ed. VII. BIBLIOGRAFIA 157

12 Antiepileptic Drug Interactions. Bethesda, MD: National Institute of Health. (1989). SWINYARD, E.A.; KUPFERBERG, H.J. (1985) - Antiepileptic drugs: detection, quantification, and evaluation. Federation Proc. 44:10 (1985) 1-5. TALLARIDA, R.J.; RAFFA, R.B. (1996) - Testing for synergism over a range of fixed ratio drug combinations: replacing the isobologram. Life Sci. 58:2 (1996) TALLARIDA, R.J.; [et al.] (1999) Response surface analysis of synergism between morphine and clonidine. J. Pharm. Exp. Ther. 289 (1999) TALLARIDA, R.J. (2001) - Drug synergism: its detection and applications. J. Pharm. Exp. Ther. 298 (2001) TALLARIDA, R.J. (2002) - The interaction index: a measure of drug synergism. Pain. 98 (2002) TECOMA, E.S. (1999) Oxcarbazepine. Epilepsia. 40: Suppl.5 (1999) S37- S46. THOMSON, A.H.; BRODIE, M.J. (1992) - Pharmacokinetic Optimisation of Anticonvulsant Therapy. Clin. Pharmacokinet. 23:3 (1992) TOMAN, J.E.P.; SWINYARD, E.A.; GOODMAN, L.S. (1946) - Properties of maximal seizures, and their alteration by anticonvulsant drugs and other agents. J. Neurophysiol. 9 (1946) TRACY, A.; GLAUSSER, M.D. (2001) - Oxcarbazepine in the treatment of epilepsy. Pharmacoterapy. 21:8 (2001) UPTON, N. (1994) - Mechanisms of action of new antiepileptic drugs: rational design and serendipitous findings. TIPS. Dec. 15 (1994) VAN OPSTAL, J. M. [et al.] (2004) Severe overdosage with the antiepileptic drug oxcarbazepine. Br. J. Clin. Pharmacol. 58:3 (2004)

13 URE, J.A.; PERASSOLO. M.; (2000) - Update on the pathophysiology of the epilepsies - review article. J. Neurolog. Sci. 177 (2000) WAMIL, A.W. [et al.] (1994) - Effects of oxcarbazepine and 10- hydroxycarmazepine on action potencial firing and generalized seizures. Eur. J. Pharmacol. 271 (1994) WHITE, H.S. (1999) - Comparative Anticonvulsant and Mechanistic Profile of the Established and Newer Antiepileptic Drugs. Epilepsia. 40 Suppl.5 (1999) S2-S10. WHITE, H.S. (2003) - Preclinical Development of Antiepileptic Drugs: Past, Present and Future directions. Epilepsia. 44 Suppl. 7 (2003) 2-8. WOLF, P. (1997). International Classification of the Epilepsies. In ENGEL, J.; PEDLEY,T.A. ed. lit. - Epilepsy: A Comprehensive Textbook. Philadelphia: Lippincott-Raven Publishers. (1997) Vol. 1 Chapter 68: p ZONA, C. [et al.]. (2002) - Neocortical potassium corrents are enhanced by the antiepileptic drug Lamotrigine. Epilepsia. 43:7 (2002) VII. BIBLIOGRAFIA 159

Isobolographic analysis of interactions among losigamone analog AO-620 and two conventional antiepileptic drugs

Isobolographic analysis of interactions among losigamone analog AO-620 and two conventional antiepileptic drugs Pharmacological Reports 2005, 57, 236 240 ISSN 1734-1140 Copyright 2005 by Institute of Pharmacology Polish Academy of Sciences Short communication Isobolographic analysis of interactions among losigamone

More information

THE MAXIMAL ELECTROSHOCK SEIZURE (MES) MODEL IN THE PRECLINICAL ASSESSMENT OF POTENTIAL NEW ANTIEPILEPTIC DRUGS

THE MAXIMAL ELECTROSHOCK SEIZURE (MES) MODEL IN THE PRECLINICAL ASSESSMENT OF POTENTIAL NEW ANTIEPILEPTIC DRUGS Methods Find Exp Clin Pharmacol 2009, 31(2): 101-106 Copyright 2009 Prous Science, S.A.U. or its licensors. All rights reserved. CCC: 0379-0355/2009 DOI: 10.1358/mf.2009.31.2.1338414 REVIEW ARTICLE THE

More information

, Jarogniew J. Łuszczki

, Jarogniew J. Łuszczki Wydawnictwo UR 2017 ISSN 2544-1361 (online); ISSN 2544-2406 doi: 10.15584/ejcem.2017.4.1 303 http://www.ejcem.ur.edu.pl/en/ European Journal of Clinical and Experimental Medicine Eur J Clin Exp Med 2017;

More information

Advances in Medical Sciences Vol. 54(1) 2009 pp DOI: /v Medical University of Bialystok, Poland

Advances in Medical Sciences Vol. 54(1) 2009 pp DOI: /v Medical University of Bialystok, Poland Advances in Medical Sciences Vol. 54(1) 2009 pp 75-81 DOI: 10.2478/v10039-009-0006-7 Medical University of Bialystok, Poland Interaction of tiagabine with valproate in the mouse pentylenetetrazole-induced

More information

Difficult to treat childhood epilepsy: Lessons from clinical case scenario

Difficult to treat childhood epilepsy: Lessons from clinical case scenario Difficult to treat childhood epilepsy: Lessons from clinical case scenario Surachai Likasitwattanakul, M.D. Department of Pediatrics Faculty of Medicine, Siriraj Hospital Natural history of Epilepsy Untreated

More information

Interactions of retigabine with topiramate in the mouse tonic-clonic seizure model and chimney test an isobolographic analysis

Interactions of retigabine with topiramate in the mouse tonic-clonic seizure model and chimney test an isobolographic analysis ORIGINAL ARTICLE Journal of Pre-Clinical and Clinical Research, 2017, Vol 11, No 1, 61-65 www.jpccr.eu Interactions of retigabine with topiramate in the mouse tonic-clonic seizure model and chimney test

More information

Evidence for Efficacy of Combination of Antiepileptic Drugs in Treatment of Epilepsy

Evidence for Efficacy of Combination of Antiepileptic Drugs in Treatment of Epilepsy Elmer ress Review J Neurol Res. 2015;5(6):267-276 Evidence for Efficacy of Combination of Antiepileptic Drugs in Treatment of Epilepsy Ehsan M. Sarhan a, b, Matthew C. Walker a, Caroline Selai a Abstract

More information

MONOTHERAPY OR POLYTHERAPY FOR CHILDHOOD EPILEPSIES?

MONOTHERAPY OR POLYTHERAPY FOR CHILDHOOD EPILEPSIES? MONOTHERAPY OR POLYTHERAPY FOR CHILDHOOD EPILEPSIES? Oluwaseun Egunsola 1, Helen M Sammons 1 and William P Whitehouse 2,3 1Academic Division of Child Health, University of Nottingham, Derbyshire Children

More information

The New England Journal of Medicine EARLY IDENTIFICATION OF REFRACTORY EPILEPSY. Patients

The New England Journal of Medicine EARLY IDENTIFICATION OF REFRACTORY EPILEPSY. Patients EARLY IDENTIFICATION OF REFRACTORY EPILEPSY PATRICK KWAN, M.D., AND MARTIN J. BRODIE, M.D. ABSTRACT Background More than 30 percent of patients with epilepsy have inadequate control of seizures with drug

More information

Discovery of Antiepileptic Drugs

Discovery of Antiepileptic Drugs Neurotherapeutics: The Journal of the American Society for Experimental NeuroTherapeutics Discovery of Antiepileptic Drugs Misty Smith, Karen S. Wilcox, and H. Steve White Anticonvulsant Drug Development

More information

International Journal of Innovative Pharmaceutical Sciences and Research

International Journal of Innovative Pharmaceutical Sciences and Research International Journal of Innovative Pharmaceutical Sciences and Research www.ijipsr.com DETERMINATION OF PROTECTIVE INDICES OF PHENYTOIN AND SODIUM VALPROATE USING MOUSE BEAM WALKING ASSAY FOR MOTOR COORDINATION

More information

Medications for Epilepsy What I Need to Know

Medications for Epilepsy What I Need to Know Medications for Epilepsy What I Need to Know Safiya Ladak, BSc.Phm. Toronto Western Hospital, UHN Clinical Pharmacist, Neurology and Neurosurgery June 4, 2016 Learning Objectives Treatment options for

More information

Therapeutic strategies in the choice of antiepileptic drugs

Therapeutic strategies in the choice of antiepileptic drugs Acta neurol. belg., 2002, 102, 6-10 Original articles Therapeutic strategies in the choice of antiepileptic drugs V. DE BORCHGRAVE, V. DELVAUX, M. DE TOURCHANINOFF, J.M. DUBRU, S. GHARIANI, Th. GRISAR,

More information

MONOTHERAPY IS PREferred

MONOTHERAPY IS PREferred Monotherapy in Epilepsy Role of the Newer Antiepileptic Drugs Blanca Vazquez, MD NEUROLOGICAL REVIEW Background: Monotherapy is the goal for pharmacological treatment of epilepsy. Well-controlled trials

More information

Concomitant administration of rifampicin and oxcarbazepine results in a significant decrease of the active MHD metabolite of oxcarbazepine

Concomitant administration of rifampicin and oxcarbazepine results in a significant decrease of the active MHD metabolite of oxcarbazepine Zurich Open Repository and Archive University of Zurich Main Library Strickhofstrasse 39 CH-8057 Zurich www.zora.uzh.ch Year: 2016 Concomitant administration of rifampicin and oxcarbazepine results in

More information

Can drug resistance in epilepsy be minimized? Challenging commonly held beliefs

Can drug resistance in epilepsy be minimized? Challenging commonly held beliefs Global care of patients with drug resistant epilepsy Epileptic Disord 2005; 7 (Suppl. 1): S14-S21 Can drug resistance in epilepsy be minimized? Challenging commonly held beliefs Emilio Perucca Clinical

More information

Topamax and lamictal interactions

Topamax and lamictal interactions Interactions of lamotrigine with topiramate and first-generation antiepileptic drugs in the maximal electroshock test in mice: an isobolographic analysis. Luszczki JJ( 1), Czuczwar M, Kis J, Krysa J, Pasztelan

More information

ANTIEPILEPTIC DRUGS FIFTH EDITION. Editors. RENE H. LEVY, PhD

ANTIEPILEPTIC DRUGS FIFTH EDITION. Editors. RENE H. LEVY, PhD ANTIEPILEPTIC DRUGS FIFTH EDITION Editors RENE H. LEVY, PhD Professor and Chair, Department of Pharmaceutics Professor of Neurological Surgery University ofwashington Schools of Pharmacy and Medicine Seattle,

More information

TRAMADOL, A CENTRALLY ACTING OPIOID : ANTICONVULSANT EFFECT AGAINST MAXIMAL ELECTROSHOCK SEIZURE IN MICE

TRAMADOL, A CENTRALLY ACTING OPIOID : ANTICONVULSANT EFFECT AGAINST MAXIMAL ELECTROSHOCK SEIZURE IN MICE Indian J Physiol Pharmacol 1998; 42 (3) : 407-411 TRAMADOL, A CENTRALLY ACTING OPIOID : ANTICONVULSANT EFFECT AGAINST MAXIMAL ELECTROSHOCK SEIZURE IN MICE ANSHU MANOCHA, KRISHNA K. SHARMA* AND PRAMOD K.

More information

Mariusz Œwi¹der 1, Hubert KuŸniar 1, Zdzis³aw Kleinrok 1, Stanis³aw J. Czuczwar 2,3,#

Mariusz Œwi¹der 1, Hubert KuŸniar 1, Zdzis³aw Kleinrok 1, Stanis³aw J. Czuczwar 2,3,# Copyright 23 by Institute of Pharmacology Polish Academy of Sciences Polish Journal of Pharmacology Pol. J. Pharmacol., 23, 55, 13 17 ISSN 123-62 SHORT COMMUNICATION INFLUENCE OF LY 3164, AN AMPA/KAINATE

More information

The ideal pharmacokinetic properties of an antiepileptic drug: how close does levetiracetam come?

The ideal pharmacokinetic properties of an antiepileptic drug: how close does levetiracetam come? Treatment of Epilepsy: Focus on Levetiracetam Epileptic Disord 2003; 5 (Suppl 1): S17 S26 The ideal pharmacokinetic properties of an antiepileptic drug: how close does levetiracetam come? Emilio Perucca

More information

Rational Polytherapy with Antiepileptic Drugs

Rational Polytherapy with Antiepileptic Drugs Pharmaceuticals 2010, 3, 2362-2379; doi:10.3390/ph3082362 Review OPEN ACCESS pharmaceuticals ISSN 1424-8247 www.mdpi.com/journal/pharmaceuticals Rational Polytherapy with Antiepileptic Drugs Jong Woo Lee

More information

When choosing an antiepileptic ... PRESENTATION... Pharmacokinetics of the New Antiepileptic Drugs. Based on a presentation by Barry E.

When choosing an antiepileptic ... PRESENTATION... Pharmacokinetics of the New Antiepileptic Drugs. Based on a presentation by Barry E. ... PRESENTATION... Pharmacokinetics of the New Antiepileptic Drugs Based on a presentation by Barry E. Gidal, PharmD Presentation Summary A physician s choice of an antiepileptic drug (AED) usually depends

More information

Is a hypothermic effect of LY , valproate and phenobarbital evident in mice?

Is a hypothermic effect of LY , valproate and phenobarbital evident in mice? 270 Świąder MJ, et al. Roczniki Akademii Medycznej w Białymstoku Vol. 49, 2004 Annales Academiae Medicae Bialostocensis Is a hypothermic effect of LY 300164, valproate and phenobarbital evident in mice?

More information

The Epilepsy Prescriber s Guide to Antiepileptic Drugs

The Epilepsy Prescriber s Guide to Antiepileptic Drugs The Epilepsy Prescriber s Guide to Antiepileptic Drugs The Epilepsy Prescriber s Guide to Antiepileptic Drugs Philip N. Patsalos FRCPath, PhD Professor of Clinical Pharmacology and Consultant Clinical

More information

New Medicines Profile

New Medicines Profile New Medicines Profile February 2010 Issue No. 10/02 Eslicarbazepine Concise evaluated information to support the managed entry of new medicines in the NHS Brand Name, (Manufacturer): Zebinix (Eisai Limited)

More information

Seizure 20 (2011) Contents lists available at ScienceDirect. Seizure. journal homepage:

Seizure 20 (2011) Contents lists available at ScienceDirect. Seizure. journal homepage: Seizure 20 (2011) 359 368 Contents lists available at ScienceDirect Seizure journal homepage: www.elsevier.com/locate/yseiz Review Critical review of current animal models of and epilepsy used in the discovery

More information

eslicarbazepine acetate 800mg tablet (Zebinix) SMC No. (592/09) Eisai Ltd

eslicarbazepine acetate 800mg tablet (Zebinix) SMC No. (592/09) Eisai Ltd eslicarbazepine acetate 800mg tablet (Zebinix) SMC No. (592/09) Eisai Ltd 8 October 2010 The Scottish Medicines Consortium (SMC) has completed its assessment of the above product and advises NHS Boards

More information

Seletracetam (UCB 44212)

Seletracetam (UCB 44212) Neurotherapeutics: The Journal of the American Society for Experimental NeuroTherapeutics Seletracetam (UCB 44212) Barbara Bennett,* Alain Matagne, Philippe Michel, Michèle Leonard, Miranda Cornet, Marie-Anne

More information

Epilepsy is a very individualized

Epilepsy is a very individualized ... PRESENTATION... Treatment of Epilepsy in 3 Specialized Populations Based on a presentation by Ilo E. Leppik, MD Presentation Summary When discussing the treatment of epilepsy, targeted populations

More information

Disclosure. Learning Objectives

Disclosure. Learning Objectives Linda D. Leary, M.D. Associate Clinical Professor of Pediatrics & Neurology South Texas Comprehensive Epilepsy Center UT Health Science Center San Antonio Disclosure Linda D. Leary, M.D. discloses the

More information

Mechanisms of Action of Antiepileptic Drugs

Mechanisms of Action of Antiepileptic Drugs Mechanisms of Action of Antiepileptic Drugs Piotr Czapiński 1, Barbara Blaszczyk 2, Stanislaw J. Czuczwar 3,4,* Current Topics in Medicinal Chemistry 2005, 5, 3-14 3 1 Center for Treatment of Epilepsy

More information

The Effectiveness of Monotheraby in Epileptic Sudanese Patients

The Effectiveness of Monotheraby in Epileptic Sudanese Patients The Effectiveness of Monotheraby in Epileptic Sudanese Patients Amel Elmahi Mohamed (1) Sawsan A Aldeaf (1) Alsadig Gassoum (1) Alnada Abdalla Mohamed (2) Mohamed A Arbab (1,3) and Alamin Ebrahim (2) Abstract

More information

Lacosamide (Vimpat) for partial-onset epilepsy monotherapy. December 2011

Lacosamide (Vimpat) for partial-onset epilepsy monotherapy. December 2011 Lacosamide (Vimpat) for partial-onset epilepsy monotherapy This technology summary is based on information available at the time of research and a limited literature search. It is not intended to be a

More information

Gabapentin synergistically interacts with topiramate in the mouse maximal electroshock seizure model: an isobolographic analysis

Gabapentin synergistically interacts with topiramate in the mouse maximal electroshock seizure model: an isobolographic analysis Pharmacological Reports 2006, 58, 944 954 ISSN 1734-1140 Copyright 2006 by Institute of Pharmacology Polish Academy of Sciences Short communication Gabapentin synergistically interacts with topiramate

More information

Interactions of Mexiletine with Novel Antiepileptic Drugs in the Maximal Electroshock Test in Mice: An Isobolographic Analysis

Interactions of Mexiletine with Novel Antiepileptic Drugs in the Maximal Electroshock Test in Mice: An Isobolographic Analysis Neurochemical Research (2018) 43:1887 1896 https://doi.org/10.1007/s11064-018-2606-8 ORIGINAL PAPER Interactions of Mexiletine with Novel Antiepileptic Drugs in the Maximal Electroshock Test in Mice: An

More information

Ernie Somerville Prince of Wales Hospital EPILEPSY

Ernie Somerville Prince of Wales Hospital EPILEPSY Ernie Somerville Prince of Wales Hospital EPILEPSY Overview Classification New and old anti-epileptic drugs (AEDs) Neuropsychiatric side-effects Limbic encephalitis Non-drug therapies Therapeutic wishlist

More information

Journal of Chemical and Pharmaceutical Research

Journal of Chemical and Pharmaceutical Research Available online www.jocpr.com Journal of Chemical and Pharmaceutical Research ISSN No: 0975-7384 CODEN(USA): JCPRC5 J. Chem. Pharm. Res., 2011, 3(5):468-472 Study on the anticonvulsant activity of Pentazocine

More information

VENKATESH NAGARADDI, MD

VENKATESH NAGARADDI, MD - 1 - VENKATESH NAGARADDI, MD 7777 Forest Lane, C-650 Dallas, Texas 75230 vnagaraddi@hotmail.com (972) 566 8579 NEUROLOGY/EPILEPTOLOGY North Dallas Epilepsy Sep, 16 present Director of Neurodiagnostics

More information

2018 American Academy of Neurology

2018 American Academy of Neurology Practice Guideline Update Efficacy and Tolerability of the New Antiepileptic Drugs I: Treatment of New-Onset Epilepsy Report by: Guideline Development, Dissemination, and Implementation Subcommittee of

More information

Introduction to seizures and epilepsy

Introduction to seizures and epilepsy Introduction to seizures and epilepsy Selim R. Benbadis, M.D. Professor Departments of Neurology & Neurosurgery Director, Comprehensive Epilepsy Program Symptomatic seizures Head injury (trauma) Stroke

More information

Zonisamide for migraine prophylaxis in refractory patients

Zonisamide for migraine prophylaxis in refractory patients Thomas Jefferson University Jefferson Digital Commons Department of Neurology Faculty Papers Department of Neurology March 2006 Zonisamide for migraine prophylaxis in refractory patients Avi Ashkenazi

More information

Monotherapy and polytherapy in Paediatric seizures: A prospective, observational study in a tertiary care teaching hospital

Monotherapy and polytherapy in Paediatric seizures: A prospective, observational study in a tertiary care teaching hospital Original Research Article Monotherapy and polytherapy in Paediatric seizures: A prospective, observational study in a tertiary care teaching hospital Henry Daniel Raj T 1, Sylvia A 2*, Chidambaranathan

More information

Trends in Utilization of Antiepileptic Drugs Among Pediatric Patients in a Tertiary Care Hospital

Trends in Utilization of Antiepileptic Drugs Among Pediatric Patients in a Tertiary Care Hospital Current Neurobiology 2011; 2 (2): 117123 Trends in Utilization of Antiepileptic Drugs Among Pediatric Patients in a Tertiary Care Hospital Maity N and Niveditha Gangadhar Department of Pharmacology, M.S

More information

Disclosures. Objectives 2/16/2015. Women with Epilepsy: Seizures in Pregnancy and Maternal/Fetal Outcomes

Disclosures. Objectives 2/16/2015. Women with Epilepsy: Seizures in Pregnancy and Maternal/Fetal Outcomes Women with Epilepsy: Seizures in Pregnancy and Maternal/Fetal Outcomes 40 th Annual Progress in OBGYN February 19, 2015 Jennifer L. DeWolfe, DO Associate Professor UAB Epilepsy Center Director, BVAMC Sleep

More information

2018 American Academy of Neurology

2018 American Academy of Neurology Practice Guideline Update Efficacy and Tolerability of the New Antiepileptic Drugs II: Treatment-Resistant Epilepsy Report by: Guideline Development, Dissemination, and Implementation Subcommittee of the

More information

Keywords: treatment; epilepsy; population based cohort Institute of Neurology, University College London, London WC1N 3BG, UK

Keywords: treatment; epilepsy; population based cohort Institute of Neurology, University College London, London WC1N 3BG, UK 632 Institute of Neurology, University College London, London WC1N 3BG, UK S D Lhatoo JWASSander S D Shorvon Correspondence to: Professor J W Sander, Department of Clinical and Experimental Epilepsy, Institute

More information

Cost-effective analysis of dual therapy in epilepsy, a study from India

Cost-effective analysis of dual therapy in epilepsy, a study from India Neurology Asia 2011; 16(4) : 309 314 Cost-effective analysis of dual therapy in epilepsy, a study from India 1 Sarita Goyal MD (Pharmacology), 2 DC Dhasmana MD (Pharmacology), 3 Deepak Goel MD DM (Neurology),

More information

Evidence for a rapid action of levetiracetam compared to topiramate in refractory partial epilepsy

Evidence for a rapid action of levetiracetam compared to topiramate in refractory partial epilepsy Seizure (2006) 15, 112 116 www.elsevier.com/locate/yseiz Evidence for a rapid action of levetiracetam compared to topiramate in refractory partial epilepsy Luigi M. Specchio a,e, *, Giovanni Boero b,e,

More information

Rationale and Evidence for the Use of Oxcarbazepine in Neuropathic Pain

Rationale and Evidence for the Use of Oxcarbazepine in Neuropathic Pain Vol. 25 No. 5S May 2003 Journal of Pain and Symptom Management S31 Neuropathic Pain: From Mechanisms to Treatment Strategies Rationale and Evidence for the Use of Oxcarbazepine in Neuropathic Pain Enrique

More information

PROCEEDINGS PHARMACOLOGIC TREATMENT CONSIDERATIONS * Dennis J. Dlugos, MD ABSTRACT

PROCEEDINGS PHARMACOLOGIC TREATMENT CONSIDERATIONS * Dennis J. Dlugos, MD ABSTRACT PHARMACOLOGIC TREATMENT CONSIDERATIONS * Dennis J. Dlugos, MD ABSTRACT A number of traditional and newer antiepileptic drugs (AEDs) are used for the initial treatment of new-onset epilepsy. The decision-making

More information

Combined Ketogenic Diet and Vagus Nerve Stimulation: Rational Polytherapy?

Combined Ketogenic Diet and Vagus Nerve Stimulation: Rational Polytherapy? Epilepsia, 48(1):77 81, 2007 Blackwell Publishing, Inc. C 2007 International League Against Epilepsy Combined Ketogenic Diet and Vagus Nerve Stimulation: Rational Polytherapy? Eric H. Kossoff, Paula L.

More information

Safety and Efficacy of Oxcarbazepine: Results of Randomized, Double-Blind Trials

Safety and Efficacy of Oxcarbazepine: Results of Randomized, Double-Blind Trials Safety and Efficacy of Oxcarbazepine: Results of Randomized, Double-Blind Trials Ahmad Beydoun, M.D. Oxcarbazepine is approved as monotherapy and adjunctive therapy for partial seizures with and without

More information

Changes in the Disposition of Oxcarbazepine and Its Metabolites during Pregnancy and the Puerperium

Changes in the Disposition of Oxcarbazepine and Its Metabolites during Pregnancy and the Puerperium Epilepsia, 47(3):4 9, 26 Blackwell Publishing, Inc. C 26 International League Against Epilepsy Changes in the Disposition of Oxcarbazepine and Its Metabolites during Pregnancy and the Puerperium Iolanda

More information

THE TREATMENT GAP AND POSSIBLE THERAPIES OF EPILEPSY IN SUB- SAHARAN AFRICA

THE TREATMENT GAP AND POSSIBLE THERAPIES OF EPILEPSY IN SUB- SAHARAN AFRICA THE TREATMENT GAP AND POSSIBLE THERAPIES OF EPILEPSY IN SUB- SAHARAN AFRICA DR A.O. CHARWAY-FELLI, MD, PhD NEUROLOGIST 37 MILITARY HOSPITAL, ACCRA, GHANA SECRETARY-GENERAL AFRICAN ACADEMY OF NEUROLOGY

More information

Characterization of epilepsy with onset after 60 years of age

Characterization of epilepsy with onset after 60 years of age http://dx.doi.org/10.1590/1809-98232016019.150074 343 Characterization of epilepsy with onset after 60 years of age Original Articles Igor Silvestre Bruscky 1 Ricardo André Amorim Leite 1 Carolina da Cunha

More information

Epilepsies of Childhood: An Over-view of Treatment 2 nd October 2018

Epilepsies of Childhood: An Over-view of Treatment 2 nd October 2018 Epilepsies of Childhood: An Over-view of Treatment 2 nd October 2018 Dr Sophia Varadkar MRCPI, PhD Consultant Paediatric Neurologist and Honorary Senior Lecturer Great Ormond Street Hospital for Children

More information

AN UPDATE ON ANTIEPILEPTIC AGENTS: FOCUS ON AN UPDATE ON ANTIEPILEPTIC AGENTS: FOCUS ON SECOND GENERATION TREATMENT OPTIONS

AN UPDATE ON ANTIEPILEPTIC AGENTS: FOCUS ON AN UPDATE ON ANTIEPILEPTIC AGENTS: FOCUS ON SECOND GENERATION TREATMENT OPTIONS Volume 24, Issue 1 October 2008 AN UPDATE ON ANTIEPILEPTIC AGENTS: FOCUS ON SECOND GENERATION TREATMENT OPTIONS Jason Richey, Pharm.D. Candidate Epilepsy is a neurological disorder characterized by sudden

More information

Odisha, India 3 Prof & HOD,Department of Pharmacology, V. S. S.Medical College, Burla, Sambalpur, Odisha, India

Odisha, India 3 Prof & HOD,Department of Pharmacology, V. S. S.Medical College, Burla, Sambalpur, Odisha, India IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) e-issn: 2279-0853, p-issn: 2279-0861.Volume 15, Issue 7 Ver. VI (July. 2016), PP 65-73 www.iosrjournals.org Effect of on the Antiepileptic Action

More information

New antiepileptic drugs

New antiepileptic drugs Chapter 29 New antiepileptic drugs J.W. SANDER UCL Institute of Neurology, University College London, National Hospital for Neurology and Neurosurgery, Queen Square, London, and Epilepsy Society, Chalfont

More information

The importance of pharmacogenetics in the treatment of epilepsy

The importance of pharmacogenetics in the treatment of epilepsy The importance of pharmacogenetics in the treatment of epilepsy Öner Süzer and Esat Eşkazan İstanbul University, Cerrahpaşa Faculty of Medicine, Department of Pharmacology and Clinical Pharmacology Introduction

More information

Optimizing Antiepileptic Drug Therapy in Refractory Epilepsy

Optimizing Antiepileptic Drug Therapy in Refractory Epilepsy 15 Optimizing Antiepileptic Drug Therapy in Refractory Epilepsy Nicholas P. Poolos Department of Neurology and UW Regional Epilepsy Center, University of Washington, Seattle, WA, USA Introduction: When

More information

Somnolence and Sedation Were Transient Adverse Events for Most Patients Receiving Clobazam Therapy: Post Hoc Analysis of Trial OV-1012 Data

Somnolence and Sedation Were Transient Adverse Events for Most Patients Receiving Clobazam Therapy: Post Hoc Analysis of Trial OV-1012 Data Elmer ress Short Communication J Neurol Res. 2015;5(4-5):252-256 Somnolence and Sedation Were Transient Adverse Events for Most Patients Receiving Clobazam Therapy: Post Hoc Analysis of Trial OV-1012 Data

More information

Introduction OPEN ACCESS. Peter Martin and Jörg Fahrbach

Introduction OPEN ACCESS. Peter Martin and Jörg Fahrbach Macedonian Journal of Medical Sciences. 2012 Mar 15; 5(1):85-89. http://dx.doi.org/10.3889/mjms.1857-5773.2011.0211 Clinical Science OPEN ACCESS Efficacy of Zonisamide Levetiracetam Comedication in Nine

More information

Antiepileptic Drugs (Anticonvulsants )

Antiepileptic Drugs (Anticonvulsants ) Antiepileptic Drugs (Anticonvulsants ) NEPHAR 305 Pharmaceutical Chemistry I Assist.Prof.Dr. Banu Keşanlı 1 Anticonvulsants Anticonvulsants, sometimes also called antiepileptics, belong to a diverse group

More information

Epilepsy. Seizures and Epilepsy. Buccal Midazolam vs. Rectal Diazepam for Serial Seizures. Epilepsy and Seizures 6/18/2008

Epilepsy. Seizures and Epilepsy. Buccal Midazolam vs. Rectal Diazepam for Serial Seizures. Epilepsy and Seizures 6/18/2008 Seizures and Epilepsy Paul Garcia, M.D. UCSF Epilepsy Epileptic seizure: the physical manifestation of aberrant firing of brain cells Epilepsy: the tendency to recurrent, unprovoked epileptic seizures

More information

D espite recent developments in the nonmedical

D espite recent developments in the nonmedical 581 REVIEW New drugs for the treatment of epilepsy: a practical approach S Beyenburg, J Bauer, M Reuber... The availability of new antiepileptic drugs has broadened the spectrum of medical treatment options

More information

Updated advice for nurses who care for patients with epilepsy

Updated advice for nurses who care for patients with epilepsy NICE BULLETIN Updated advice for nurses who care for patients with epilepsy NICE provided the content for this booklet which is independent of any company or product advertised NICE BULLETIN Updated advice

More information

New treatment option for partial-onset seizures: efficacy and safety of lacosamide

New treatment option for partial-onset seizures: efficacy and safety of lacosamide Therapeutic Advances in Neurological Disorders Review New treatment option for partial-onset seizures: efficacy and safety of lacosamide Steve S. Chung Ther Adv Neurol Disord (2010) 3(2) 77 83 DOI: 10.1177/

More information

Monotherapy in Newly Diagnosed Epilepsy: Levetiracetam Versus Standard Anticonvulsants

Monotherapy in Newly Diagnosed Epilepsy: Levetiracetam Versus Standard Anticonvulsants Monotherapy in Newly Diagnosed Epilepsy: Levetiracetam Versus Standard Anticonvulsants Current Literature In Clinical Science KOMET: An Unblinded, Randomised, Two Parallel-Group, Stratified Trial Comparing

More information

Mechanisms of action of antiepileptic drugs

Mechanisms of action of antiepileptic drugs Mechanisms of action of antiepileptic drugs Chapter 25 GRAEME J. SILLS Department of Molecular and Clinical Pharmacology, University of Liverpool Introduction The serendipitous discovery of the anticonvulsant

More information

Do seizures beget seizures?

Do seizures beget seizures? Does MTLE cause progressive neurocognitive damage? Andrew Bleasel Westmead Do seizures beget seizures? The tendency of the disease is toward self-perpetuation; each attack facilitates occurrence of another

More information

Pharmacological Treatment of Non-Lesional Epilepsy December 8, 2013

Pharmacological Treatment of Non-Lesional Epilepsy December 8, 2013 Pharmacological Treatment of Non-Lesional Epilepsy December 8, 2013 Michael Privitera, MD Professor of Neurology University of Cincinnati, Neuroscience Institute American Epilepsy Society Annual Meeting

More information

PRO- AND ANTIAPOPTOPIC EFFECTS OF ANTICONVULSANT DRUGS

PRO- AND ANTIAPOPTOPIC EFFECTS OF ANTICONVULSANT DRUGS PROGRESS IN ETIOPATHOGENESIS SEIZURES PRO- AND ANTIAPOPTOPIC EFFECTS OF ANTICONVULSANT DRUGS W³adys³aw Lasoñ Institute of Pharmacology, Polish Academy of Sciences, Smêtna 12, PL 31-343 Kraków, Poland According

More information

Deralakatte, Mangalore, India Dept of Pharmacology, Yenepoya Medical College, Yenepoya University,

Deralakatte, Mangalore, India Dept of Pharmacology, Yenepoya Medical College, Yenepoya University, International Journal of Universal Pharmacy and Bio Sciences 2(3): May-June 2013 INTERNATIONAL JOURNAL OF UNIVERSAL PHARMACY AND BIO SCIENCES Pharmaceutical Sciences Research Article!!! Received: 02-05-2013;

More information

Preliminary Evaluation of the Antiepileptic Activity of Lacosamide in Libyan Epileptic Center.

Preliminary Evaluation of the Antiepileptic Activity of Lacosamide in Libyan Epileptic Center. J. Pharm. Appl. Chem. 4, No. 2, 91-97 (2018) 91 Journal of Pharmaceutical and Applied Chemistry An International Journal http://dx.doi.org/10.18576/jpac/040203 Preliminary Evaluation of the Antiepileptic

More information

There has been a history of problems with

There has been a history of problems with UNDERSTANDING THE RAMIFICATIONS OF SWITCHING AMONG AEDS: WHAT ARE THE DATA? Gail D. Anderson, PhD* ABSTRACT Historically, there have been problems with generic versions of older antiepileptic drugs (AEDs),

More information

Anticonvulsants Antiseizure

Anticonvulsants Antiseizure Anticonvulsants Antiseizure Seizure disorders Head trauma Stroke Drugs (overdose, withdrawal) Brain tumor Encephalitis/ Meningitis High fever Hypoglycemia Hypocalcemia Hypoxia genetic factors Epileptic

More information

Predictors of Intractable Childhood Epilepsy

Predictors of Intractable Childhood Epilepsy ORIGINAL ARTICLE Predictors of Intractable Childhood Epilepsy Muhammad Akbar Malik 1, Muhammad Haroon Hamid 2, Tahir Masood Ahmed 2 and Qurban Ali 3 ABSTRACT Objective: To determine the prognosis of seizures

More information

Modified release drug delivery system for antiepileptic drug (Formulation development and evaluation).

Modified release drug delivery system for antiepileptic drug (Formulation development and evaluation). TITLE OF THE THESIS / RESEARCH: Modified release drug delivery system for antiepileptic drug (Formulation development and evaluation). INTRODUCTION: Epilepsy is a common chronic neurological disorder characterized

More information

Children Are Not Just Small Adults Choosing AEDs in Children

Children Are Not Just Small Adults Choosing AEDs in Children Children Are Not Just Small Adults Choosing AEDs in Children Natrujee Wiwattanadittakun, MD Neurology division, Department of Pediatrics, Chiang Mai University Hospital, Chiang Mai University 20 th July,

More information

Review of Anticonvulsant Medications: Traditional and Alternative Uses. Andrea Michel, PharmD, CACP

Review of Anticonvulsant Medications: Traditional and Alternative Uses. Andrea Michel, PharmD, CACP Review of Anticonvulsant Medications: Traditional and Alternative Uses Andrea Michel, PharmD, CACP Objectives Review epidemiology of epilepsy Classify types of seizures Discuss non-pharmacologic and pharmacologic

More information

Clinical Policy: Clobazam (Onfi) Reference Number: CP.PMN.54. Line of Business: Medicaid

Clinical Policy: Clobazam (Onfi) Reference Number: CP.PMN.54. Line of Business: Medicaid Clinical Policy: (Onfi) Reference Number: CP.PMN.54 Effective Date: 11/12 Last Review Date: 05/17 Line of Business: Medicaid Coding Implications Revision Log See Important Reminder at the end of this policy

More information

A Clinical Overview of the New Antiepileptic Drugs

A Clinical Overview of the New Antiepileptic Drugs Bahrain Medical Bulletin, Vol.28, No.3, September 2006 A Clinical Overview of the New Antiepileptic Drugs Dr. Shoaa F. Al-Shammary* Over the past decade, several new antiepileptic drugs (AEDs) have become

More information

This is a refereed journal and all articles are professionally screened and reviewed

This is a refereed journal and all articles are professionally screened and reviewed Advances in Environmental Biology, 5(7): 1866-1870, 2011 ISSN 1995-0756 1866 This is a refereed journal and all articles are professionally screened and reviewed ORIGINAL ARTICLE Effect of Nimodipine on

More information

ARTICLES Monotherapy in adults and elderly persons

ARTICLES Monotherapy in adults and elderly persons ARTICLES Monotherapy in adults and elderly persons Edward Faught, MD Address correspondence and reprint requests to Dr. Edward Faught, Department of Neurology, University of Alabama at Birmingham Epilepsy

More information

Overview: Idiopathic Generalized Epilepsies

Overview: Idiopathic Generalized Epilepsies Epilepsia, 44(Suppl. 2):2 6, 2003 Blackwell Publishing, Inc. 2003 International League Against Epilepsy Overview: Idiopathic Generalized Epilepsies Richard H. Mattson Department of Neurology, Yale University

More information

New drugs necessity for therapeutic drug monitoring

New drugs necessity for therapeutic drug monitoring New drugs necessity for therapeutic drug monitoring Stephan Krähenbühl Clinical Pharmacology & Toxicology University Hospital Basel kraehenbuehl@uhbs.ch Drugs suitable for TDM Narrow therapeutic range

More information

Seizure control with antiepileptic drug therapy in 517 consecutive adult outpatients at the Kork Epilepsy Centre

Seizure control with antiepileptic drug therapy in 517 consecutive adult outpatients at the Kork Epilepsy Centre Original article Epileptic Disord 2012; 14 (4): 379-87 Seizure control with antiepileptic drug therapy in 517 consecutive adult outpatients at the Kork Epilepsy Centre Bernhard J Steinhoff, Anke Maren

More information

Pharmaco-epidemiological and pharmaco-economic analysis of antiepileptic drugs at a tertiary level health care centre - a crosssectional

Pharmaco-epidemiological and pharmaco-economic analysis of antiepileptic drugs at a tertiary level health care centre - a crosssectional Original article: Pharmaco-epidemiological and pharmaco-economic analysis of antiepileptic drugs at a tertiary level health care centre - a crosssectional prospective study Dr. Shraddha Tatkare 1 *, Dr.

More information

WHY CHILDREN ARE DIFFERENT FROM ADULTS

WHY CHILDREN ARE DIFFERENT FROM ADULTS XXASIM May p159-165 5/14/01 9:23 AM Page 159 NEW PHARMACOLOGICAL TREATMENTS FOR PEDIATRIC EPILEPSY Blaise F.D. Bourgeois, MD KEY POINTS Antiepileptic drugs (AEDs) are tailored to pediatric epilepsy seizure

More information

Risk of seizure recurrence after antiepileptic drug withdrawal, an Indian study

Risk of seizure recurrence after antiepileptic drug withdrawal, an Indian study Neurology Asia 2006; 11 : 19 23 Risk of seizure recurrence after antiepileptic drug withdrawal, an Indian study Archana VERMA DM (Neurology) MD, Surendra MISRA DM (Neurology) FRCP (Edin) Department of

More information

AED Treatment Approaches. David Spencer, MD Director, OHSU Epilepsy Center Professor, Department of Neurology

AED Treatment Approaches. David Spencer, MD Director, OHSU Epilepsy Center Professor, Department of Neurology AED Treatment Approaches David Spencer, MD Director, OHSU Epilepsy Center Professor, Department of Neurology Audience Response Keypads Please utilize the keypad at your table to answer questions throughout

More information

p ผศ.นพ.ร งสรรค ช ยเสว ก ล คณะแพทยศาสตร ศ ร ราชพยาบาล

p ผศ.นพ.ร งสรรค ช ยเสว ก ล คณะแพทยศาสตร ศ ร ราชพยาบาล Natural Course and Prognosis of Epilepsy p ผศ.นพ.ร งสรรค ช ยเสว ก ล คณะแพทยศาสตร ศ ร ราชพยาบาล Introduction Prognosis of epilepsy generally means probability of being seizure-free after starting treatment

More information

Role of rufinamide in the management of Lennox-Gastaut syndrome (childhood epileptic encephalopathy)

Role of rufinamide in the management of Lennox-Gastaut syndrome (childhood epileptic encephalopathy) EXPERT OPINION Role of rufinamide in the management of Lennox-Gastaut syndrome (childhood epileptic encephalopathy) Gerhard Kluger 1 Bettina Bauer 2 1 Klinik für Neuropädiatrie und Neurologische Rehabilitation,

More information

Generic Name (Brand Name) Available Strengths Formulary Limits. Primidone (Mysoline) 50mg, 250mg -- $

Generic Name (Brand Name) Available Strengths Formulary Limits. Primidone (Mysoline) 50mg, 250mg -- $ MEDICATION COVERAGE POLICY PHARMACY AND THERAPEUTICS ADVISORY COMMITTEE POLICY: Epilepsy P&T DATE: 2/15/2017 THERAPEUTIC CLASS: Neurologic Disorders REVIEW HISTORY: 2/16 LOB AFFECTED: Medi-Cal (MONTH/YEAR)

More information

Revisiting the Ketogenic Diet and Related Therapies in the Modern Era

Revisiting the Ketogenic Diet and Related Therapies in the Modern Era Revisiting the Ketogenic Diet and Related Therapies in the Modern Era Heung Dong Kim M.D., Ph.D. Pediatric Epilepsy Clinic, Division of Pediatric Neurology Severance Children s Hospital Yonsei University

More information

Using antiepileptic drugs in children: recent developments and recommendations

Using antiepileptic drugs in children: recent developments and recommendations Using antiepileptic drugs in children: recent developments and recommendations 1 Hana Shabbi, 1 Anne Marie Scerri, 2 Doriette M Soler, 1 Janet Mifsud 1 Department of Clinical Pharmacology and Therapeutics,

More information

The new generation of antiepileptic drugs: advantages and disadvantages

The new generation of antiepileptic drugs: advantages and disadvantages Br J Clin Pharmacoll996; 42: 531-543 The new generation of antiepileptic drugs: advantages and disadvantages EMILIO PERUCCA Clinical Pharmacology Unit, Department of Internal Medicine and Therapeutics,

More information

An Introduction to Antiepileptic Drugs

An Introduction to Antiepileptic Drugs Epilepsia, 46(Suppl. 4):31 37, 2005 Blackwell Publishing, Inc. C International League Against Epilepsy An Introduction to Antiepileptic Drugs Emilio Perucca Clinical Pharmacology Unit, Department of Internal

More information