The Use of Adjunctive Venography and Endovascular Manoeuvres In The Treatment of Saphenous Vein Insufficiency. A Prospective, Multi-centre Study
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1 The Use of Adjunctive Venography and Endovascular Manoeuvres In The Treatment of Saphenous Vein Insufficiency A Prospective, Multi-centre Study Ramon L. Varcoe, MBBS, MS, FRACS, PhD Associate Professor of Vascular Surgery University of New South Wales Sydney, Australia
2 Disclosure Speaker name:...ramon L. Varcoe... I have the following potential conflicts of interest to report: Consulting: Medtronic, Abbott Vascular, Boston Employment in industry Stockholder of a healthcare company Owner of a healthcare company Other(s) I do not have any potential conflict of interest
3 Ultrasound for Saphenous Vein Rx High quality Real-time imaging Without radiation Guide venous access Visualise ablation catheter Tumescence
4 ? Limitations of Ultrasound Anatomical complexities Venous strictures Duplicate saphenous systems Severe tortuosity Segmental occlusions Aneurysms Venous confluence deep within the leg
5
6 Prospective, Multi-Centre design Study Design Inclusion Criteria >18 yo CEAP 2-6 Great-, small-, inter-saphenous or perforator ablation (RFA or CAE) Sonographic reflux >0.5 sec Exclusion Criteria Pregnant patients Contrast allergy Renal impairment Those undergoing: Surgical ligation/stripping Simple phlebectomy Pelvic embolization Rx for May-Thurner syndrome
7 Prospective, Multi-Centre design Study Design Inclusion Criteria >18 yo CEAP 2-6 Great-, small-, inter-saphenous or perforator ablation (RFA or CAE) Sonographic reflux >0.5 sec Exclusion Criteria Pregnant patients Contrast allergy Renal impairment Those undergoing: Surgical ligation/stripping Simple phlebectomy Pelvic embolization Rx for May-Thurner syndrome
8 Prospective, Multi-Centre design Study Design Inclusion Criteria >18 yo CEAP 2-6 Great-, small-, inter-saphenous or perforator ablation (RFA or CAE) Sonographic reflux >0.5 sec Exclusion Criteria Pregnant patients Contrast allergy Renal impairment Those undergoing: Surgical ligation/stripping Simple phlebectomy Pelvic embolization Rx for May-Thurner syndrome
9 Prospective, Multi-Centre design Inclusion Criteria >18 yo CEAP 2-6 Great-, small-, inter-saphenous or perforator ablation (RFA or CAE) Sonographic reflux >0.5 sec 305 Venous trunks 268 Limbs 200 Patients Study Design Exclusion Criteria Pregnant patients Contrast allergy Renal impairment Those undergoing: Surgical ligation/stripping Simple phlebectomy Pelvic embolization Rx for May-Thurner syndrome October 2010 to May 2016
10 Patient Demographics n = 200 Age (mean ± SD, range) 60.9 ± 12.9 (33-86) Women 128 (64%) Number of legs treated 268 Number of saphenous trunks 305 Treatment Indication Primary varicose veins 169 (85%) Recurrent varicose veins 23 (12%) Thrombophlebitis 2 (1%) Ulceration 6 (3%) CEAP Classification C2 Varicose veins 85 (43%) C3 Oedema 65 (33%) C4 Skin changes 30 (15%) C5 Healed ulcer 5 (3%) C6 Active ulcer 12 (6%)
11 Patient Demographics n = 200 Age (mean ± SD, range) 60.9 ± 12.9 (33-86) Women 128 (64%) Number of legs treated 268 Number of saphenous trunks 305 Treatment Indication Primary varicose veins 169 (85%) Recurrent varicose veins 23 (12%) Thrombophlebitis 2 (1%) Ulceration 6 (3%) CEAP Classification C2 Varicose veins 85 (43%) C3 Oedema 65 (33%) C4 Skin changes 30 (15%) C5 Healed ulcer 5 (3%) C6 Active ulcer 12 (6%)
12 Patient Demographics n = 200 Age (mean ± SD, range) 60.9 ± 12.9 (33-86) Women 128 (64%) Number of legs treated 268 Number of saphenous trunks 305 Treatment Indication Primary varicose veins 169 (85%) Recurrent varicose veins 23 (12%) Thrombophlebitis 2 (1%) Ulceration 6 (3%) CEAP Classification C2 Varicose veins 85 (43%) C3 Oedema 65 (33%) C4 Skin changes 30 (15%) C5 Healed ulcer 5 (3%) C6 Active ulcer 12 (6%)
13 Insufficient Vein n = 305 Great saphenous 241 (79%) Small Saphenous 38 (13%) Anterior accessory great saphenous 6 (2%) Inter-saphenous (Giacomini) 10 (3%) Perforator 10 (3%)
14 542 runs Mean 2.0/limb Median 1.0/limb Venography Mean Time: 4.9 ±9.1 min (range 1-48) Nil contrast related morbidity* *CIN, Anaphylaxis, Anaphylactoid reactions
15 Venous Anomalies in 66%
16 Venous Anomalies in 66% Duplicate System 33%
17 Venous Anomalies in 66% Duplicate System Aneurysm 33% 28%
18 Venous Anomalies in 66% Duplicate System Aneurysm Stenosis 33% 28% 21%
19 Venous Anomalies in 66% Duplicate System Aneurysm Stenosis Large Incompetent Perforator 33% 28% 21% 11%
20 Venous Anomalies in 66% Duplicate System Aneurysm Stenosis Large Incompetent Perforator Saphenous Occlusion 33% 28% 21% 11% 4%
21 Venous Anomalies in 66% Duplicate System Aneurysm Stenosis Large Incompetent Perforator Saphenous Occlusion Filling Defect (Thrombus) 33% 28% 21% 11% 4% 3%
22
23 Adjunctive Manoeuvres in 44%
24 Adjunctive Manoeuvres in 44% Manoeuvre n = 200 Use of a low profile guide wire and angled catheter 53 (27%)
25 Use of a low profile guide wire and angled catheter 27% *
26 Adjunctive Manoeuvres in 44% Manoeuvre n = 200 Use of a low profile guide wire and angled catheter 53 (27%) Use of additional RFA or CAE in dilated segment 30 (15%)
27 Use of additional RFA or CAE in dilated segment 15%
28 Adjunctive Manoeuvres in 44% Manoeuvre n = 200 Use of a low profile guide wire and angled catheter 53 (27%) Use of additional RFA or CAE in dilated segment 30 (15%) Simultaneous treatment of multiple incompetent saphenous vein trunks 4 (2%) Selective cannulation of an incompetent saphenous vein 24 (12%)
29 Selective Cannulation in 12% Treated multiple Trunks in 2%
30
31
32 Adjunctive Manoeuvres in 44% Manoeuvre n = 200 Use of a low profile guide wire and angled catheter 53 (27%) Use of additional RFA or CAE in dilated segment 30 (15%) Simultaneous treatment of multiple incompetent saphenous vein trunks 4 (2%) Selective cannulation of an incompetent saphenous vein Fluoroscopic guidance to negotiate the superficialdeep-vein junction Fluoroscopic guidance to position the radiofrequency probe 24 (12%) 6 (3%) 27 (14%)
33 Fluoroscopic guided probe positioning in 14%
34
35 Self Reported Rate of 34/200 (17%) UNABLE TO COMPLETE Rx WITHOUT XRAY Where the operator felt that the procedure would have to be left incomplete or converted to foam without an endovascular manoeuvre.
36 Self Reported Rate of 34/200 (17%) Required Manoeuvre n = 34 Selective cannulation of an incompetent saphenous 14 (41%) trunk required Severe Tortuosity 13 (38%) Stenosis Preventing Passage of Probe/Catheter 9 (27%) Occluded Saphenous Vein (with an incompetent proximal segment) 5 (15%)
37 Based on mean 2.0 runs/limb 0.74 msv/limb Risk 1 in 36,000 fatal cancer * Source: Australian Radiation Protection and Nuclear Safety Agency
38 Based on mean 2.0 runs/limb 0.74 msv/limb Risk 1 in 36,000 fatal cancer Compared with 1.5 msv - a year s environmental exposure 1-5 msv CT Brain 5-10 msv Coronary angiography >10 msv CT Abdo/Pelvis (multi-phase) * Source: Australian Radiation Protection and Nuclear Safety Agency
39 Based on mean 2.0 runs/limb 0.74 msv/limb Risk 1 in 36,000 fatal cancer Compared with 1.5 msv - a year s environmental exposure 1-5 msv CT Brain 5-10 msv Coronary angiography >10 msv CT Abdo/Pelvis (multi-phase) Thorough treatment Less failures Less foam conversion Less recurrence * Source: Australian Radiation Protection and Nuclear Safety Agency
40 Summary A significant number of venous anomalies go unrecognised by standard duplex imaging A number of those (44%) benefit from x-ray guided endovascular assistance Without that assistance 1 in 5 will be left with incomplete treatment or converted to foam There is definite value in using x-ray guidance in selected patients
41 The Use of Adjunctive Venography and Endovascular Manoeuvres In The Treatment of Saphenous Vein Insufficiency A Prospective, Multi-centre Study Ramon L. Varcoe, MBBS, MS, FRACS, PhD Associate Professor of Vascular Surgery University of New South Wales Sydney, Australia
42 The Use of Adjunctive Venography and Endovascular Manoeuvres In The Treatment of Saphenous Vein Insufficiency A Prospective, Multi-centre Study Ramon L. Varcoe, MBBS, MS, FRACS, PhD Associate Professor of Vascular Surgery University of New South Wales Sydney, Australia
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