TREATMENT OPTIONS FOR CHRONIC VENOUS INSUFFICIENCY
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1 TREATMENT OPTIONS FOR CHRONIC VENOUS INSUFFICIENCY TL LUK Consultant Vascular Surgeon Sarawak General Hospital HKL Vascular Conference 19/06/2013
2 PREVALENCE OF LOWER LIMB VENOUS DISEASE Affects half of adult population. 80% have reticular or spider varices 30-50% have truncal varicose veins 5-10% have skin changes of chronic venous insufficiency (CVI) 1% have chronic venous ulcer (CVI)
3 SYMPTOMATIC VASCULAR DISEASE PREVALENCE Source: American Heart Association, SIR, Brand et al. The Epidemiology of Varicose Veins: The Framingham Study 3
4 LOWER LIMB VENOUS INSUFFICIENCY Very common condition Given low priority, both clinically & research Lead to significant reductions in health related quality of life (HRQL) Adequate treatment especially surgical intervention has been shown to significantly improve quality of life despite high recurrence rate
5 ONLY AROUND 25% OF POTENTIAL PATIENTS WERE TREATED ADEQUATELY Symptomatic seeking treatment Saphenous procedures 1.2M 312K 5
6 FLOWCHART FOR CVI
7 TREATMENT MODALITY Conservative Compression stockings/bandage Medication: daflon, pentoxyphylline Open Surgery Ligation & Stripping Endovenous Surgery EVLA RFA Foam Sclerotherapy
8 COMPRESSION mmhg compression required Class 2 compression stocking Below Knee generally adequate Only effective when worn Require replacement every 6 month Lifelong compliance a issue
9 SURGICAL INTERVENTION Patients with VV prefer and get better outcome from surgery than from compression only Provides symptomatic relief and significant improvement in quality of life even in patients with uncomplicated varicose veins
10 SUPERFICIAL VENOUS DISEASE Surgical options: Open surgery Endovenous surgery
11 VEIN LIGATION & STRIPPING: TRADITIONAL STANDARD OF CARE Groin incision and vein ligation Vein stripper inserted into GSV Stripped vein Procedure: Invasive Requires general anaesthesia in hospital Recovery: Post-op pain and bruising ~2 weeks until back to work 11
12 ENDOVENOUS SURGERY Involve percutaneous placement of catheter to deliver energy source to create damage to vein wall Less morbidity less pain and bruising post op No groin incision less risk of infection & scarring Reduced risk of nerve damage Can be done with tumescent anaesthetic alone
13 ENDOVENOUS SURGERY Two main energy source Laser Radio frequency Major developments over the last 10 years Accepted by vascular surgeons worldwide as first line treatment for varicose veins Results comparable to traditional vein ligation & stripping
14 ENDOVENOUS LASER (EVL)
15 EVL FDA approval % VV in US treated using laser 810 nm laser was the original wavelength used. Changes since then: 980nm, 1064nm, 1320nm, 1470nm More durable smaller fibres Radial fibres
16 Marketed by various companies Endovenous tumescent anaesthesia under ultrasound guidance technique Mechanism: Direct absorption of photon energy Indirectly from steam bubbles and conduction from heated blood EVL
17 EVL Complications: Bruising/haematoma Thromboplebitis/cel lulitis Numbness/nerve damage DVT/PE Retinal damage
18 BRUISING POST SURGERY 18
19 RADIOFREQUENCY ABLATION (RFA)
20 RFA Marketed by Covidien US guided endovenous procedure Segmental ablation technology Heating element treats 7cm of vein at once
21 VEIN MAPPING Make indentions in skin using a straw Remove ultrasound gel from leg Connect marks on the leg with surgical marker to identify pathway of vein and important anatomy 21
22 VEIN ACCESS Percutaneous access Ultrasound guided Transverse or longitudinal view Good access site Poor access site (multiple collateral veins) 22
23 VEIN ACCESS Flashback through needle hub and visualization confirms vein access 23
24 TUMESCENT INFILTRATION Injection into saphenous compartment under ultrasound guidance Observe vein compression around catheter Confirm vein depth 1cm from skin surface Tip position re-confirmed and adjusted as needed after infiltration 24
25 CONDUCTIVE HEATING Conductive heating is heat transmitted through direct contact Radiofrequency energy used to heat catheter coil Vein wall tissue conductively heated to induce collagen contraction and eventual fibrotic sealing of vein 25
26 METHOD OF ACTION: COLLAGEN CONTRACTION Effect of controlled heating of vein wall: Heat sensitive bonds break at 60 C Molecular structure begins to uncoil Collagen fibers shorten and thicken Vein collagen shrinkage results in obliteration of lumen Results in eventual fibrotic sealing of vessel Heat Collagen triple helix molecule Collagen fibers contract lengthwise and expand in diameter 26
27 ACUTE POST-OP SCAN Perform acute scan to confirm procedure success Check CFV, SFJ and SEV for patency Document GSV residual lumen Demonstrate occlusion of GSV using colour Doppler 27
28 FOLLOW-UP DUPLEX ASSESSMENT Periodic follow-up thereafter (eg. 3 months, 6 months and annually) Variable appearance of treated vein in terms of: Echogenicity Compressibility 28
29 RFA TRIAL REPORT 5 year result of multicentre European trial reported at American College of Phebology 12/2012 Eight centers in Europe from April 2006 to June 2007, enrolled 235 patients to treat 295 lower limbs Post op duplex ultrasound imaging and clinical examination at 3 days, 3 months, 6 months, and in yearly intervals up to 5 years At 5-year follow-up by Kaplan-Meier analysis, full occlusion of the treated vein observed in 92% of patients (vs 98% at 1 year).
30 20 patients ( 2012) Large VV ->1cm SGH EXPERIENCE Performed under GA in theatre setting Together with multiple avulsions LSV completely occluded to 12 months All patients satisfied with results & would undertake the procedure again
31 2 WEEKS POST PROCEDURE
32 PERFORATOR SURGERY US guided perforator ligation Subfascial Endoscopic Perforator Surgery (SEPS) Open/endovenous
33 OTHER ENDOVENOUS OPTIONS Clarivein Venaseal/superglue Steam Foam slerotherapy
34 DEEP VENOUS SYSTEM Thrombolysis/thrombe ctomy Endovascular venous plasty/stenting Valve reconstruction Venous bypass surgery
35 SUMMARY Lower limb chronic venous insufficiency is a very common condition. Surgical treatment can significantly improve quality of life. Endovenous Surgery is as effective as traditional surgery and has less complications.
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