Clinical Assessment of Heart Disease Using Cardiac Biomerker in Dogs and Cats

Size: px

Start display at page:

Download "Clinical Assessment of Heart Disease Using Cardiac Biomerker in Dogs and Cats"

Gervase McLaughlin
5 years ago
Views:

1 (2011) Clinical Assessment of Heart Disease Using Cardiac Biomerker in Dogs and Cats Yasutomo HORI Department of Small Animal Internal Medicine, School of Veterinary Medicine, Kitasato University, Higashi, Towada, Aomori Japan (ANP) B- (BNP) ANP BNP, NT-proBNP ANP BNP ANP BNP ANP BNP ANP NT-proBNP X ANP, NT-proBNP (2011) Tel: Fax: hori@vmas.kitasato-u.ac.jp 1

2 (Atrial Natriuretic Peptide; ANP) B- (Btype Natriuretic Peptide; BNP), 1. ANP 28 BNP 32 1) ANP BNP N-terminal proanp (NT-proANP) N-terminal probnp (NT-proBNP) 13) ANP 4, 5) BNP BNP NT-proBNP 13) Fig. 1 ANP NT-proBNP ml/kg/hr, 60 ANP NT-proBNP (BL) ANP NT-proBNP ANP ANP NT-proBNP A ANP B NT-proBNP C ANP NT-proBNP p0.05 vs. 60 min; p0.01 vs. BL; p0.001 vs. BL. (Hori Y, et al. 2010) 2

3 BNP 6, 7) ANP 8) NT-proBNP (Fig. 1). ANP 8) Qi ANP BNP 24 9) ANP BNP 24 9) ANP BNP (Natriuretic Peptide Receptor; NPR) NPR cgmp NPR A, B, C ANP BNP NPR-A ANP BNP 1) (Fig. 2) ANP BNP ANP Fig. 2 ANP BNP ANP BNP -A cgmp (Ruskoaho H, 2003) 14 10) BNP ANP 11) NT-proANP NT-proBNP ANP BNP 1, 12) ANP BNP 2. ANP BNP, NTproBNP 1315) 2.1 BNP NT-proBNP 1419) Takemura International Small 3

4 Animal Cardiac Health Council (ISACHC) II IIIa NTproBNP pmol/l ) NT-proBNP pmol/l pmol/l NT-proBNP BNP NT-proBNP 16, 20) Fig. 3 ISACHC ANP ISACHC I; 17 II; 26 IIIa; 14 IIIb; 21 ANP p0.01 vs. control, p vs. control, p0.01 vs. ISACHC I (Hori Y, et al. in press) ANP 14, 21) ANP pg/ml ISACHC ANP (Fig. 3) ANP 25 pg/ml ISACHC I ANP 100 pg/ml ISACHC IIIb ) ANP LA/Ao 14, 21) ANP 2.2 Chetboul NT-proBNP 1 22) NT-proBNP Greco ANP (95 pg / ml) ANP (95 pg/ml) 23) NT-proBNP ANP 4

5 BNP NT-proBNP 17, 24, 25) NT-proBNP 1 28 ANP NTproBNP 2.3 ANP BNP ANP BNP 26, 27) NTproBNP ANP 28) (Fig. 4) ANP BNP ANP 29) NT-proANP BNP 30) ANP BNP NT-proBNP BNP ANP 16) NT-proANP NT-proBNP 24) Fig. 4 ANP NT-proBNP ANP BL 3 6 BL NT-proBNP 3 6 BL vs. BL, p0.05; vs. BL, p0.01. (Hori Y, et al. 2008) 5

6 ANP NTproBNP 3. NT-proBNP (IDEXX), ANP SRL ANP ANP ANP ANP NT-proBNP EDTA ANP 34 ANP BNP ANP BNP 31, 32) ANP BNP 17, 33) X 4. Aramaki NTproBNP 34) NT-proBNP 6

7 1) Ruskoaho, H. (2003): Cardiac hormones as diagnostic tools in heart failure. Endocr. Rev., 24, ) Seilhamer, J. J., Arfsten, A., Miller, J. A., Lundquist, P., Scarborough, R. M., Lewicki, J. A. and J. G. Porter (1989): Human and canine gene homologs of porcine brain natriuretic peptide. Biochem. Biophys. Res. Commun., 165, ) Asano, K., Murakami, M., Endo, D., Kimura, T. and T. Fujinaga (1999): Complementary DNA cloning, tissue distribution, and synthesis of canine brain natriuretic peptide. Am. J. Vet. Res., 60, ) Moe, G. W., Grima, E. A., Wong, N. L., Howard, R. J. and P. W. Armstrong (1996): Plasma and cardiac tissue atrial and brain natriuretic peptides in experimental heart failure. J. Am. Coll. Cardiol., 27, ) Maeda, K., Tsutamoto, T., Wada, A., Mabuchi, N., Hayashi, M., Hisanaga, T., Kamijo, T. and M. Kinoshita (2000): Insu$cient secretion of atrial natriuretic peptide at acute phase of myocardial infarction. J. Appl. Physiol., 89, ) Magga, J., Vuolteenaho, O., Tokola, H., Marttila, M. and H. Ruskoaho (1997): Involvement of transcriptional and posttranscriptional mechanisms in cardiac overload-induced increase of B-type natriuretic peptide gene expression. Circ. Res., 81, ) Maczewski, M. and U. Mackiewicz (2007): Plasma brain natriuretic peptide correlates with infarct size but not with subsequent remodeling in the rat heart. Cardiovasc. Pathol., 16, ) Hori, Y., Sano, N., Kanai, K., Hoshi, F., Itoh, N. and S. I. Higuchi (2010): Acute cardiac volume load-related changes in plasma atrial natriuretic peptide and N-terminal pro-b-type natriuretic peptide concentrations in healthy dogs. Vet. J., 185, ) Qi, W., Kjekshus, J. and C. Hall (2000): Di#erential responses of plasma atrial and brain natriuretic peptides to acute alteration in atrial pressure in pigs. Scand. J. Clin. Lab. Invest., 60, ) Takemura, N., Koyama, H., Sako, T., Ando, K., Suzuki, K., Motoyoshi, S. and F. Marumo (1990): Pharmacokinetics of human alphaatrial natriuretic peptide (alpha-hanp) in cow and dog. Nippon Juigaku Zasshi., 52, ) Thomas, C. J. and R. L. Woods (2003): Haemodynamic action of B-type natriuretic peptide substantially outlasts its plasma half-life in conscious dogs. Clin. Exp. Pharmacol. Physiol., 30, ) Morello, A. M. and J. L. Januzzi (2006): Aminoterminal pro-brain natriuretic peptide: A biomarker for diagnosis, prognosis and management of heart failure. Expert. Rev. Mol. Diagn., 6, ) Tsutamoto, T., Wada, A., Maeda, K., Hisanaga, T., Maeda, Y., Fukai, D., Ohnishi, M., Sugimoto, Y. and M. Kinoshita (1997): Attenuation of compensation of endogenous cardiac natriuretic peptide system in chronic heart failure: prognostic role of plasma brain natriuretic peptide concentration in patients with chronic symptomatic left ventricular dysfunction. Circulation, 96, ) Asano, K., Masuda, K., Okumura, M., Kadosawa, T. and T. Fujinaga (1999): Plasma atrial and brain natriuretic peptide levels in dogs with congestive heart failure. J. Vet. Med. Sci., 61, ) Oyama, M. A., Fox, P. R., Rush, J. E., Rozanski, E. A. and M. Lesser (2008): Clinical utility of serum N-terminal pro-b-type natriuretic peptide concentration for identifying cardiac disease in dogs and assessing disease severity. J. Am. Vet. Med. Assoc., 232, ) Oyama, M. A., Sisson, D. D. and P. F. Solter (2007): Prospective screening for occult cardiomyopathy in dogs by measurement of plasma 7

8 atrial natriuretic peptide, B-type natriuretic peptide, and cardiac troponin-i concentrations. Am. J. Vet. Res., 68, ) DeFrancesco, T. C., Rush, J. E., Rozanski, E. A., Hansen, B. D., Keene, B. W., Moore, D. T. and C. E. Atkins (2007): Prospective clinical evaluation of an ELISA B-type natriuretic peptide assay in the diagnosis of congestive heart failure in dogs presenting with cough or dyspnea. J. Vet. Intern. Med., 21, ) MacDonald, K. A., Kittleson, M. D., Munro, C. and P. Kass (2003): Brain natriuretic peptide concentration in dogs with heart disease and congestive heart failure. J. Vet. Intern. Med., 17, ) Takemura, N., Toda, N., Miyagawa, Y., Asano, K., Tejima, K., Kanno, N., Arisawa, K., Kurita, T., Nunokawa, K., Hirakawa, A., Tanaka, S. and H. Hirose (2009): Evaluation of plasma N- terminal pro-brain natriuretic peptide (NTproBNP) concentrations in dogs with mitral valve insu$ciency. J. Vet. Med. Sci., 71, ) Baumwart, R. D. and K. M. Meurs (2005): Assessment of plasma brain natriuretic peptide concentration in Boxers with arrhythmogenic right ventricular cardiomyopathy. Am. J. Vet. Res., 66, ) Hori, Y., Yamano, S., Kanai, K., Hoshi, F., Itoh, N. and S. Higuchi: Clinical implications of plasma atrial natriuretic peptide levels in dogs with spontaneous heart disease. J. Am. Vet. Med. Assoc. (in press). 22) Chetboul, V., Serresm, F., Tissier, R., Lefebvre, H. P., Sampedrano, C. C., Gouni, V., Poujol, L., Hawa, G. and J. L. Pouchelon (2009): Association of plasma N-terminal pro-b-type natriuretic peptide concentration with mitral regurgitation severity and outcome in dogs with asymptomatic degenerative mitral valve disease. J. Vet. Intern. Med. 23, ) Greco, D. S., Biller, B. and C. H. Van Liew (2003): Measurement of plasma atrial natriuretic peptide as an indicator of prognosis in dogs with cardiac disease. Can. Vet. J., 44, ) Prosek, R., Sisson, D. D., Oyama, M. A. and P. F. Solter (2007): Distinguishing cardiac and noncardiac dyspnea in 48 dogs using plasma atrial natriuretic factor, B-type natriuretic factor, endothelin, and cardiac troponin-i. J. Vet. Intern. Med., 21, ) Rutten, F. H., Cramer, M. J., Zuitho#, N. P., Lammers, J. W., Verweij, W., Grobbee, D. E. and A. W. Hoes (2007): Comparison of B-type natriuretic peptide assays for identifying heart failure in stable elderly patients with a clinical diagnosis of chronic obstructive pulmonary disease. Eur. J. Heart Fail., 9, ) Lang, C. C., Choy, A. M., Turner, K., Tobin, R., Coutie, W., and A. D. Struthers (1993): The e#ect of intravenous saline loading on plasma levels of brain natriuretic peptide in man. J. Hypertens., 11, ) Wambach, G. and J. Koch (1995): BNP plasma levels during acute volume expansion and chronic sodium loading in normal men. Clin. Exp. Hypertens., 17, ) Hori, Y., Tsubaki, M., Katou, A., Ono, Y., Yonezawa, T., Li, X. and S. I. Higuchi (2008): Evaluation of NT-pro BNP and CT-ANP as markers of concentric hypertrophy in dogs with a model of compensated aortic stenosis. J. Vet. Intern. Med., 22, ) Yoshimura, M., Yasue, H., Okumura, K., Ogawa, H., Jougasaki, M., Mukoyama, M., Nakao, K. and H. Imura (1993): Di#erent secretion patterns of atrial natriuretic peptide and brain natriuretic peptide in patients with congestive heart failure. Circulation, 87, ) Berger, R., Huelsmann, M., Strecker, K., Moertl, D., Moser, P., Bojic, A., and R. Pacher (2005): Neurohormonal risk stratification for sudden death and death owing to progressive heart failure in chronic heart failure. Eur. J. Clin. Invest., 35, ) Luchner, A., Stevens, T. L., Borgeson, D. D., Redfield, M., Wei, C. M., Porter, J. G. and J. C. 8

9 Burnett, Jr. (1998): Di#erential atrial and ventricular expression of myocardial BNP during evolution of heart failure. Am. J. Physiol., 274, H1684H ) Lisy, O., Redfield, M. M., Schirger, J. A. and J. C. Burnett, Jr. (2005): Atrial BNP endocrine function during chronic unloading of the normal canine heart. Am. J. Physiol. Regul. Integr. Comp. Physiol., 288, R158R ) Boswood, A., Dukes-McEwan, J., Loureiro, J., James, R. A., Martin, M., Sta#ord-Johnson, M., Smith, P., Little, C. and S. Attree (2008): The diagnostic accuracy of di#erent natriuretic peptides in the investigation of canine cardiac disease. J. Small Anim. Pract., 49, ) Aramaki, Y., Chimura, S., Hori, Y. and T. Eguchi (2011): Therapeutic changes of plasma N-terminal pro-brain natriuretic peptide concentrations in 9 dogs with patent ductus arteriosus. J. Vet. Med. Sci., 73,

Proceedings of the 36th World Small Animal Veterinary Congress WSAVA

www.ivis.org Proceedings of the 36th World Small Animal Veterinary Congress WSAVA Oct. 14-17, 2011 Jeju, Korea Next Congress: Reprinted in IVIS with the permission of WSAVA http://www.ivis.org 14(Fri)