Zagreb, 16. Listopad 2012
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1 Zagreb, 16. Listopad 2012
2 Fond za ulaganje u znanost i inovacije IPA komponenta III C Regionalni razvoj-regionalna konkurentnost Projekt je sufinanciran od Europske Unije Uspostava istraživačke infrastrukture za translacijsku medicinu i primijenjenu genomiku
3 Institut Rudjer Bošković Implementacija projekta Voditelj Medicinski Fakultet Zagreb Partner
4 Financije EU (75%) nacionalno sufinanciranje (25%) Grant Total: EUR ,24 iskorišteno: ca. EUR ,00
5 Nekoliko administrativni detalji... Trajanje: 18 mj. ( ) Izvještaji: kvartalni, 1 interim (M12), 1 završni, vremenici rada... Projekt monitoring: redovni sastanci sa MZOŠ, SAFU, EU predstavnicima Tendering: međunarodno, nacionalno i lokalno prateći upute PRAGa (PRAG guidelines) Novo zapošljavanje: lokalni oglasi (Narodne Novine, dnevni list, webstranica instituta) Putni troškovi: EU per diem pravila
6 Implementacija Institut Rudjer Bošković Oliver Vugrek, PhD Robert Belužić, PhD Ines Cigula, dipl. oec. Vesna Simunović, PhD* Andreja Čupić, dipl. ing. * Medicinski Fakultet Zagreb Ivo Barić, PhD, MD Ksenija Fumić, PhD,MD Mario Ćuk, MD Smiljka Vikic-Topic, M. Sc Željka Majić, dipl. ing. * * Zaposlenici na IPA projektu
7 Istraživačka infrastruktura za translacijsku medicinu... Lab Lab Bolest Pacijent Bench to bedside...
8 Diagnostika Prikaz iz drevnih vremena - Al-Razi tijekom uroskopije Point of Care Testing (POCT) jučer
9 Alergije: Pandemija... Izazovi danas...
10 Izazovi... Intolerancija na hranu...
11 Izazovi danas... Eksplosivi i biohazardi...
12 Izazovi danas... Infektivne bolesti zračne luke...
13 Izazovi danas... Drugs of Abuse testovi
14 Mikročip aplikacije - detekcija Monitoring hrane i zagađenja okoliša...
15 Izazovi danas... Zradvlje čovjeka (+ životinja)... Diagnostics Alergije Otrov / toksini Mlijeko Bolesti (životinje) Tumor markeri Kardio markeri Genotipizacija Mikrobiologija poznati alergeni ricin detekcija kontaminacija antibioticima anthrax, rabies, BSE jajnik, dojka, prostata, mehur, jetra, bubreg, gušterača, pluča, glava/vrat, leukemije etc... Troponin, BNP, probnp, etc... Krvne grupe, trombofilija, hiperkoleresterinemia, etc... sepsis, bakterijske infekcije, etc...
16 Point of Care Testing (POCT) - danas Rapidni testovi Hepatitis, HIV, Malaria, Syphilis Allergy Anemia Cardiac Marker Chagas Disease Chlamydia Cholera Dengue DIC Marker E. coli Fertility Filiariasis Group A Streptococcus Group B Streptococcus Hantavirus Hepatitis C Influenza A Leishmaniasis Leptospirosis Listeria Peptic ulcer Rheumatoid Factor Rickettsia Salmonella Thyroid Marker Tuberculosis Tumor Marker
17 Point of Care Testing (POCT)- sutra Handheld Devices (Biosensors)
18 Glavni cilj projekta... INOVACIJA Platforma za mikročip izradu i primjenu nove tehnologije
19 Minimalno invazivno (urin, krv, bris, znoj...) Mikročipovi za diagnostiku Zašto mikročipovi? Miniaturizacija - smanjenje uzorka i troškova Multi parametrijski testovi na jednom mikročipu
20 Nekoliko ekonomskih parametra... Mikročip tržište globalno u 2010.g.: $2.6 mlrd Predikcija do 2015.g.: $5.6 mlrd Rast (CAGR, compound annual growth rate) : 16.7%. Tržište Protein micročipovi - najbrže rastući segment: prognoza CAGR od 19.9% Sudjelovanje u mikročip tehnologiji utječe na regionalnu konkurentnost i pretstavlja priliku za regionalnu ekonomiju
21 Infrastruktura...
22 Mikročip priprema predmetnice 300 pl jažice bilo koji oblik... crte
23 Miniaturizirani ELISA test testova u 1 > 4 testova
24 Miniaturizirani ELISA (shema mikročipa) marker marker marker marker marker marker marker marker Primjer: procijena rizika srčanih smetnji (hs-crp) (A) nema povečani rizik (B) Povečani rizik (C) 4X povečani rizik
25 Sažetak IPA projekta... Platforma za mikročip dizajn, izradu i analizu za bazična istraživanja i primjenu u diagnostici Concept Design Klinička istraživanja Bazična istraživanja Mikročipovi - DNA, protein, antitijela, šečeri, kemikalije etc... Čip dizajn Production Mikročip izrada Application Bažična istraživanja Diagnostika & Detekcija
26 Sažetak... Tangible Opipljivo Infrastruktura (Hardware) Mikročipovi Zapošljavanje etc Non-tangible Znanje & Know-how Edukacija & trening Bolje umreživanje Bolji inovacijski potencijal Regionala ekonomija
27 Mikročip budučnosti (RH)... Ubuduće: Doprinos za zdravstvo i POCT u RH
28 Have we achieved our goals...? What are the results...? Poruka za put kući... (take home message...) Jesmo li nešto naučili za budučnost...? Bez inovacija vrlo skromni napredak!
29 Thank you for your attention!
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Telephone: Téléphone : Fax: Télécopieur :
Health Santé Health and Healthy Living Santé et Vie saine Public Health Division Division de la santé publique Communicable Disease Control Branch Prévention des maladies transmissibles Fourth Floor, 300
Telephone: (204) Téléphone: (204) Fax: (204) Télécopieur: (204)
Health Santé Healthy Living Division and Health Programs Division de la vie saine et des programmes de santé Public Health Branch Direction de la santé publique Communicable Disease Control Unit Prévention
Non-reproductive tissues and cells
Colour key Tested pathogen VIRAL Minimum requirements as set out in Directive 2004/23/EC More stringent testing - legy binding on national level More stringent testing - recommended on national level Not
Telephone: Téléphone : Fax: Télécopieur :
Health Santé Health and Healthy Living Santé et Vie saine Public Health Division Division de la santé publique Communicable Disease Control Branch Prévention des maladies transmissibles Fourth Floor, 300
Leading Causes of Death, Tarrant County, 2008
Tarrant County Public Health Division of Epidemiology and Health Information Leading Causes of Death, Tarrant County, 00 Table 1. deaths by gender, Tarrant County, 00 Male,7. 70. Female,7 0.1 7. Total,7