Bi-Ventricular pacing after the most recent studies
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1 Seminars of the Hellenic Working Groups February 18th-20 20,, 2010, Thessaloniki, Greece Bi-Ventricular pacing after the most recent studies Maurizio Lunati MD Director EP Lab & Unit Cardiology Dpt. Niguarda Hospital Milan Italy
2 ACC/AHA/HRS Guidelines 2008
3 Italian guidelines AIAC 2006 Cardiac Resynchronisation Therapy Class I Indication Synus Rhythm, Reduced EF ( 35%) Ventricular Dyssynchrony (QRS > 120ms) NYHA III-IV despite Optimal Medical Therapy Class II Indications Synus Rhythm, Reduced EF ( 35%) Ventricular Dyssynchrony (QRS > 120ms) Symptomatic (NYHA II) and with pacing indication or Primary Prevention ICD indication Chronic Right Ventricular Pacing, Reduced EF ( 35%) Severe Ventricular Dyssynchrony NYHA III-IV despite Optimal Medical Therapy Pts In Atrial Fibrillation, Reduced EF ( 35%) Ventricular Dyssynchrony (QRS > 120ms) NYHA III-IV despite Optimal Medical Therapy Reduced EF ( 35%), QRS 120 ms Ventricular Dyssynchrony (Echo assessment) NYHA III-IV despite Optimal Medical Therapy
4 CRT: Open issues Patients in I/II NYHA functional class Patients with indication to chronic right ventricular pacing Patients with chronic atrial fibrillation Patients without electrical dyssynchrony
5 CRT: Open issues Patients in I/II NYHA functional class Patients with indication to chronic right ventricular stimulation Patients with chronic atrial fibrillation Patients without electrical dyssynchrony
6 CRT in NYHA II 186 pts in NYHA II, FE < 35% and QRS > 130ms randomized CRT ON vs CRT OFF Proportion 60% 40% 20% Clinical Composite Score 58% 36% 34% 31% 22% 20% cm Left Ventricular End Diastolic Volume P=0.04 cm Left Ventricular End Systolic Volume P=0.01 0% Improved No Change Worsened CRT OFF (n=101) CRT ON (n=85) Base 6 Mo CRT (n=69) Base 6 Mo CRT OFF (n=85) End Point CRT OFF CRT ON P Change in peak VO2 0.2± ± Change in exercise duration, s 37±186 42± % Left Ventricular Ejection Fraction P=0.02 Change in NYHA 0.01±0.63) 0.18± Change in QOL 10.7± ± Change in 6MHWT, m 33±98 38± Abraham et al., MIRACLE ICD II, Circulation Base 6 Mo
7 CRT in NYHA II 132 pts in NYHA I-II and QRS > 120ms (study subgrup) Higgins SL et al JACC 2003
8 CRT for NYHA II 952 pts analyzed: NYHA II (188 pts) vs NYHA III-IV (764) Reduction of major CV events NYHA class improvement with different % Same reverse remodeling Landolina M et al. AJC 2007
9 CRT in NYHA I-II: REVERSE & MADIT CRT The evidence!
10 CRT in NYHA II: REVERSE & MADIT CRT REVERSE presented at ACC patients (Europe) followed for 24 months Age (mean) yrs 61.3 ± 10.4 Ischemic 44% NYHA II 83% EF 27.1 ± 6.8 LVEDD (mm) 68.8 ± 9.2 MADIT-CRT presented at ESC patients (US&Europe) >30 months Age (mean) yrs Ischemic NYHA N.A. N.A. I+II EF <30% LVEDD (mm) >55 QRS (ms) ICD therapy optional 156 ± 23 68% QRS (ms) ICD therapy mandatory > % CRT OFF 82 Patients CRT ON 180 Patients CRT OFF ~728 Patients CRT ON ~1092 Patients Daubert et al JACC 2009 Moss et al NEJM 2009
11 CRT in NYHA II: REVERSE Primary End Point: Clinical Composite Response at 24-month % worsened Daubert et al JACC 2009 Entire distribution analysis of worsened, unchanged and improved: P=0.0006
12 CRT in NYHA II: REVERSE Powered Secondary End Point: LVESVi 110 LVESVi (ml/m 2 ) CRT OFF 91.6 CRT ON P< Daubert et al JACC 2009 Months Since Randomization P-value compares 24-month changes.
13 CRT in NYHA II: REVERSE Other Remodeling Parameters LVEDVi (ml/m2) LVEF (%) LVEDVi (ml/m 2 ) CRT OFF CRT ON P< Months LVEF (%) CRT ON CRT OFF P< Months Daubert et al JACC 2009 P-value compares 24-month changes.
14 CRT in NYHA II: MADIT CRT confirms REVERSE Improvements in LV function with CRT-D Changes from baseline to 1-year follow-up Moss et al NEJM 2009
15 CRT in NYHA II: REVERSE Other Secondary Endpoints: Functional Paramaters 30 Minnesota Living with HF Score 500 Six-minute Hall Walk (m) 100% NYHA Class CRT OFF CRT ON CRT ON CRT OFF 80% 60% 40% 20% % Class I or II p=0.17 % NYHA Class I 10 P= P= % Months Months Months P-values compares 24-month changes. P-value compares 24-month NYHA. Daubert et al JACC 2009
16 CRT in NYHA II: REVERSE Time to First HF Hospitalization or Death Percentage Hospitalized for HF or Died 30% 25% 20% 15% 10% 5% 0% HR (95%CI): 0.38 ( ) P=0.003 CRT OFF Months Since Randomization CRT ON 24.0% 11.7% Number at Risk CRT OFF CRT ON Daubert et al JACC 2009
17 CRT in NYHA II: MADIT CRT confirms REVERSE Primary endpoint: Heart Failure or Death Moss et al NEJM 2009
18 Predictive value of QRS: MADIT CRT-REVERSE MADIT CRT P for interaction: REVERSE 24-months
19 CRT in NYHA II: REVERSE & MADIT CRT CRT reduces Morbidity and Mortality in asymptomatic HF Patients with LVD and wide QRS REVERSE Presented at ACC09 Presented results show that CRT MADIT-CRT Presented at ESC Presented results show that CRT is associated with a Significanty reduces time to first HF hospitalization or death 1 by 62 percent (HR 0.38 ( ) p=0.003 within 24 months 1 Note:ime to First HF hospitalization or death was not the primary endpoint When compared to OMT, ICD optional Daubert et al JACC 2009 Significant 34 percent reduction (p<0.001) in death or heart failure interventions within 33 months When compared to OMT, ICD mandatory Moss et al NEJM 2009
20 There is clear and solid evidence of the benefits of Prophylactic CRT in terms of clinical outcome and verntricular remodeling
21 CRT: Open issues Patients in I/II NYHA functional class Patients with indication to chronic right ventricular pacing Patients with chronic atrial fibrillation Patients without electrical dyssynchrony
22 CRT in pts with AV block 50 pts with complete A-V block and normal pump function randomized single site RV pacing or BIV pacing Conclusions: BIV pacing preserved LV pump function and minimized LV dyssynchrony as compared to conventional RV pacing; LV pump function decreased significantly and LV dyssynchrony was more pronounced in the RV pacing group Albertsen AE et al Europace 2008
23 CRT in pts with bradycardia 177 pts with bradycardia and normal EF implanted with a CRT device Randomization 1:1 Biventricular pacing versus Right Ventricular Apical pacing Primary end-point: LVEF and LVESV at 12 mos FU Yu et al NEJM Nov 2009
24 CRT in pts with bradycardia 177 pts with bradycardia and normal EF implanted with a CRT device Randomization 1:1 Biventricular pacing versus Right Ventricular Apical pacing Subgroup analysis of LVEF and LVESV Yu et al NEJM Nov 2009
25 BioPace study Randomized, multicentric, prospective, single-blind, parallel-groupdesign International (EMEAC + Australia) 1st large scaled randomized study looking at the prevention of mechanical desynchronization Extend the benefit of BiV pacing to a broader patient population Enrollment Goal centers Follow-up phase Evaluate whether patients with standard pacing indication (pacemaker or ICD) any standard-indication for permanent ventricular pacing LVEF without any limitation any QRS-width benefit from the prevention of ventricular remodeling (induced by RV pacing) with the implantation of a BiV pacing system A landmark study which results will impact the future of pacemaker therapy
26 Biventricular pacing in patients with normal systolic function who should undergo conventional pacing (right ventricular apex) can prevent adverse left ventricular remodeling and reduction of left ventricular ejection fraction (PM-induced myopathy).
27 CRT: Open issues Patients in I/II NYHA functional class Patients with indication to chronic right ventricular stimulation Patients with chronic atrial fibrillation Patients without electrical dyssynchrony
28 CRT and AF Evaluation of CRT in 263 consecutive pts, 96 with chronic AF and 167 in sinus rhythm NYHA QOL LVEF Delnoy et al., Am J Cardiol 2007
29 CRT and AF In 162 pts with permanent AF vs 511 pts in SR 162 pts with permanent AF where: 48 pts with rhythm control by drugs; 114 pts with AVJ ablation Gasparini et al., JACC 2006
30 CRT and AF In 86 pts with AF vs 209 pts in SR 86 pts with AF where: 66 permanent AF, 20 paroxismal AF Khadjooi et al., Heart 2008
31 Biventricular pacing is as effective in patients with chronic atrial fibrillation as in patients in synus rhythm.
32 CRT: Open issues Patients in I/II NYHA functional class Patients with indication to chronic right ventricular stimulation Patients with chronic atrial fibrillation Patients without electrical dyssynchrony
33 QRS duration and dyssynchrony QRS Duration and IVMD QRS 150 ms (32%) QRS < 110 ms (46%) 110 ms QRS < 150 ms (22%) 74% 77% 68% 26% 23% 32% IVMD < IVMD < IVMD < Ghio et al EHJ 2004
34 Achilli et al. JACC 2003 CRT and narrow QRS 52 patients with severe HF and with echocardiographic evidence of interventricular and intraventricular asynchrony received biventricular pacing: ,4 3,5 Group 1: QRS > 120 ms (38pts); Group 2: QRS < 120 ms (14pts) NYHA CLASS 3,3 1,8 1,8 1,7 * * * All patients Group 1 Group \ 264 Baseline Follow-up MINUTES WALKING TEST * * ** All patients Group 1 Group \ 264 Baseline Follow-up EJECTION FRACTION 33,4 33,2 33, ,6 24,6 * * * All patients Group 1 Group \ 264 * p<0,001 vs baseline; ** p<0,01 vs baseline Baseline Follow-up LVESD 64,7 64,8 61,4 57,9 57,9 55,6 * ** ** All patients Group 1 Group \ 264 Baseline Follow-up
35 CRT and narrow QRS 172 pts with narrow QRS (<130ms), EF<35% and NYHA III Randomization 1:1 CRT ON vs CRT OFF "has raised an important question relevant to clinical practice, but due to methodological choices, was unable to provide any clear response to the question asked." Dr. J Daubert Beshai et al., RETHIN Q; NEJM 2007
36 We have no current guidance for doing something (CRT) in patients without wide QRS and dyssynchrony only.
37 EHJ 2009
38 EHJ 2009
39 ...our experience... 21% 560 patients Mean age: 63,7 + 10,9 yrs 79% female male Clinical Service data
40 Conclusions Cardiac Resynchronisation Therapy Class I Indication Synus Rhythm, Reduced EF ( 35%) Class II Indications Ventricular Dyssynchrony (QRS > 120ms) NYHA III-IV despite Optimal Medical Therapy Synus Rhythm, Reduced EF ( 35%) Ventricular Dyssynchrony (QRS > 120ms) Strong evidence!!! Symptomatic (NYHA II) and with pacing indication or Primary Prevention ICD indication Chronic Right Ventricular Pacing, Reduced EF ( 35%) Severe Ventricular Dyssynchrony Convincing evidence! NYHA III-IV despite Optimal Medical Therapy Pts In Atrial Fibrillation, Reduced EF ( 35%) Ventricular Dyssynchrony (QRS > 120ms) NYHA III-IV despite Optimal Medical Therapy Strong evidence!! Reduced EF ( 35%), QRS 120 ms Ventricular Dyssynchrony (Echo assessment) NYHA III-IV despite Optimal Medical Therapy Need of other RCTs
41 The future... Babec's Story On September 25th, 2004, the Birmingham Zoo successfully implanted the first cardiac resynchronization therapy device, or CRT, in a gorilla. One year later Babec is still alive, an unlikely scenario without the device, and his quality of life is significantly improved from that prior to surgery. Babec died in years later CRT!!!
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