La chiusura dell auricola per la prevenzione dello stroke nel paziente con FA
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1 Antonio Manari U.O. Cardiologia Interventistica Azienda Ospedaliera Santa Maria Nuova Reggio Emilia Istituto di Ricovero e Cura a Carattere Scientifico La chiusura dell auricola per la prevenzione dello stroke nel paziente con FA S. Margherita 17 febbraio 2012
2 Who Gets Atrial Tachyarrhythmias? Atrial Fibrillation Demographics by Age Feinberg WM, Blackshear JL, Laupacis A. Arch Intern Med. 1995;155:
3 Prevalence of AF and Strokes attributable to AF by age. 40% 35% 30% 25% 20% 15% Prevalence of AF Strokes Attributable to AF 10% 5% 0% Framingham Study, Wolf, 1991
4 Efficacy of Antithrombotic Treatment in Non-Valvular Atrial Fibrillation META ANALYSIS 26 Trials 28,044 Patients Mean Age 71 Years Mean Follow up 1.5 years Comparison Trials Patients Reduction in Stroke Warfarin Vs. Control 6 2,900 64% Antiplatelet agents vs. control 8 4,876 22% Warfarin vs. Antiplatelet 12 12,963 39% Har RG, Ann Intern Med 2007; 146:857-86
5 Anticoagulation in atrial fibrillation Stroke risk reductions warfarin better control better AFASAK SPAF BAATAF Stroke: RRR 62% All-cause mortality: RRR 26% CAFA SPINAF EAFT Severe bleedings: 1.2%/year Aggregate 100% 50% 0-50% -100%
6 ESC Guidelines 2010 on the management of Atrial Fibrillation Warfarin is the gold standard in patients with atrial fibrillation. Eur Heart J 2010
7 REAL WORLD USE OF WARFARIN IN AF PATIENTS WITHOUT CONTRAINDICATIONS % Harrold et al, 2002 McCormick et al, 2001 Samsa et al, 2000 CQInv, 1998 Sudlow et al, 1998 Brass et al, 1997 Gurwitz et al, 1997 Whittle et al, 1997 Albers et al, 1997 Stafford & Singer, 1996 Lip et al, 1994 Bath et al,
8 Non-Valvular Atrial Fibrillation Warfarin use in AF Patients by Age % ,1 60,7 57,3 44,3 35,4 < Only 55% of AF patients with no contraindications have evidence of warfarin use in previous 3 months Other studies cite warfarin use in AF patients from 17-50% Elderly patients with increased absolute risk least likely to be taking warfarin Contraindications 30-40% Ann Int Med 131(12), 1999
9 Age-related trends in AF Unmet need >89 Age, years Wolf PA, Arch Intern Med 1987; 147: White RH, Am J Med 1999; 106:165-71
10 Narrow anticoagulant therapeutic window Hylek EM et al, N Engl J Med 1996; 335: Stroke risk increases at INR < 2 Bleeding risk increases at INR >3
11 Non-Valvular Atrial Fibrillation Adequacy of Anticoagulation in Clinic Low INR <1.6 Therapeutic INR 2-3 Efficacy 4-fold High INR >3.2 Bungard, Pharmacotherapy 20:1060, % 11
12 ORAL ANTICOAGULATION AND RISK OF BLEEDING ISCOAT Study 2,745 pts ns PT / YEAR % ELDERLY PTS Major bleeds N= 461 Age > 75 (79.9) YOUNG PTS All bleeds N= 461 Age < 70 (56.5) Palareti et al, Arch Intern Med 2000; 160:
13 RCT s & Warfarin INR al momento dello Stroke INR Ratio AFASAK CAFA SPAF I BAATAF SPINAF PT Ratio (ISI 2.4) ACCP raccomandazioni: INR: Target range per ogni studio
14 Risk adjusted percent time in therapeutic range as a quality indicator for out-patient oral anticoagulation: results of the Veterans Affairs Study to Improve Anticoagulation (VARIA). Rose AJ, Circ Cardiovasc Qual Outcomes 2011;4:22-9 In a recent analysis of anticoagulation management involving more than 120,000 patients in the Veterans Affairs health care system, the mean proportion of time in the therapeutic range was 58%, with significant variation across Sites.
15 Percentuale di tempo con INR in range in RCTs in era contemporanea % , Rivaroxaban Apixaban Dabigatran (2011) (2011) (2009)
16
17 Aderenza alla terapia nei RCTs in era contemporanea Rocket-AF% sospensione del farmaco ARISTOTLE% sospensione del farmaco ,7 Rivaroxaban 22,2 Warfarin ,3 Apixaban 27,5 Warfarin RE LY% sospensione del farmaco Dab 110 Dab 150 Warfarin
18 Rocket-AF % sospensione del farmaco The median duration of treatment exposure was 590 days; the median follow-up period was 707 days ,7 22,2 15 Rivaroxaban Warfarin
19
20 6 5 4,43 5,1 4, ,29 2,6 2,43 3,25 1 0,82 0,89 0 Dab 110 Dab 150 Warfarin < >75
21 6 5 5,29 5,44 5, ,89 1,53 3,33 2,09 3,76 2, Dab 110 Dab 150 Warfarin Cl Crea<50 Cl Crea50-70 Cl Crea >80
22 6 5, ,3 2,91 2,56 4,92 3,13 4,01 3,75 3, Dab 110 Dab 150 Warfarin Peso<50 Peso50-99 Peso100
23 ARISTOTLE Apixaban vs Warfarin
24 a high risk of bleeding (e.g., active peptic ulcer disease, a platelet count of <100,000 per cubic millimeter or hemoglobin level of <10 g per deciliter, stroke within the previous 10 days, documented hemorrhagic tendencies, or blood dyscrasias),
25 Prevenzione dello stroke embolico nella Fibrillazione Atriale
26
27
28 Mechanism of Stroke in Patients with AF
29 Devices per la chiusura percutanea
30 Left atrial appendage closure
31 Left atrial appendage closure
32 Left atrial appendage closure
33 Left atrial appendage closure
34 Left atrial appendage closure
35 Left atrial appendage closure
36 Left atrial appendage closure
37 Left atrial appendage closure
38 Left atrial appendage closure
39 Left atrial appendage closure
40 Left atrial appendage closure
41 PROTECT-AF Trial Enrollment Summary Randomized Patients N=707 Implant successful in 90.9% (408/449) of attempts Warfarin Control Group N=244 WATCHMAN Device Group N=463 Warfarin Started N=241 Warfarin Never Started N=3 Implant Attempted N=449 No Attempt N=14 Window For Procedure Lapsed N=10 Procedural Event N=12 Device Release Criteria Not Met* N=29 Unable to Implant N=41 Device Implanted N=408 Other N=3 Patient Died Before Procedure N=1 Included In Primary Analysis * One or more of the release criteria of acceptable device position, in-situ size (compression), stability, and LAA seal were not met for device release. 41 April 23, 2009
42 Primary Efficacy Results (CV deaths, stroke, systemic embolization) 707 pts with non-valvular AF (CHADS 2 1) Device Randomization allocation (2 device : 1 control) Control Posterior Probabilities Events Total Rate Events Total Rate Rel. Risk Non- Cohort (no.) pt-yr (95% CI) (no.) pt-yr (95% CI) (95% CI) inferiority Superiority 900 pt-yr (2.1, 5.2) (2.8, 7.6) (0.37, 1.41) 1 Event-free probability 0,9 WATCHMAN Control ITT Cohort: patients analyzed based on their randomly assigned group (regardless of treatment received) 0, Days
43 All Stroke Device Control Posterior probabilities Events Total Rate Events Total Rate RR Non- Superiority Cohort eve pt-yr (95% CI) (no.) pt-yr (95% CI) (95% CI) inferiority pt-yr (1.9, 5.5) (1.5, 6.3) (0.43, 2.57) pt-yr (1.5, 4.1) (1.7, 5.7) (0.36, 1.76) Event-free probability 1 0,9 0,8 900 patient-year analysis 0, Days Device Control Randomization allocation (2 device:1 control) ITT cohort: patients analyzed based on their randomly assigned group (regardless of treatment received)
44 Hemorrhagic Stroke Device Control Posterior probabilities Events Total Rate Events Total Rate RR Non- Superiority Cohort (no.) pt-yr (95% CI) (no.) pt-yr (95% CI) (95% CI) inferiority pt-yr (0.0, 0.9) (0.5, 3.9) (0.00, 0.80) > pt-yr (0.0, 0.6) (0.7, 3.7) (0.00, 0.45) Event-free probability 900 patient-year analysis Device Control Days Randomization allocation (2 device:1 control) ITT cohort: patients analyzed based on their randomly assigned group (regardless of treatment received)
45 Intent-to-Treat Primary Safety Results Randomization allocation (2 device : 1 control) Device Control Events Total Rate Events Total Rate Rel. Risk Cohort (no.) pt-yr (95% CI) (no.) pt-yr (95% CI) (95% CI) 900 pt-yr (6.4, 11.3) (2.2, 6.7) (1.18, 4.13) 1 Event-free probability 0,9 WATCHMAN Control ITT Cohort: patients analyzed based on their randomly assigned group (regardless of treatment received) 0, Days
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48 LAA occlusion Atrial fibrillation High risk of stroke Contraindication to OAC High risk of bleeding with OAC Difficult to maintain INR within the therapeutic range Poor compliance Difficulty to manage the patient because ol ogistic problems
49
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