CURRICULUM VITAE Name PUNNEE BUTTHEP Education Mailing Address: Research interest : Professional and Appointments Other Experience and activities:

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1 CURRICULUM VITAE Name PUNNEE BUTTHEP (พรรณ บ ตรเทพ) Education Ph.D. Medical science, Kobe University School of Medicine, Japan M.Sc. Clinical Pathology, Mahidol University B.Sc. Medical Technology, Chiang Mai University Mailing Address: Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Rama VI Road, Bangkok 10400, Thailand. Phone: ; Fax: Research interest : Hematology, Cytometry, Cell and tissue culture and Cell analysis Professional and Appointments 1999-present Associate Professor, Dept. of Pathology, Faculty of Medicine, Ramathibodi Hospital Other Experience and activities: 1989 (Sept.-Nov.) Study of In Vitro cultivation of Vascular endothelial cells, Kobe University School of Medicine, Kobe, Japan 1992 (Sept.-Dec.) Autologous culture of epithelium for skin replacement, university of California San Diego, USA Committee of cell Culture for Medical Use, Ramathibodi Hospital 1999-Present Committee of Clinical Pathology Program (M.Sc. and Ph.D.) Dept. of Pathology, Faculty of Medicine Ramathibodi Hospital Present Director of Clinical Pathology Program (M.Sc and Ph.D.) Dept. of Pathology, Faculty of Medicine Ramathibody Hospital 2004-Present Project Director of Blood Disease Diagnostic Center, Sirikit Medical Center Total Publications: About 74 Publications

2 Publication : (เร ยงจากป จจ บ น อด ต) International publication : Sanyear C, Butthep P, Nithipongvanich R, Sirankapracha P, Winichagoon P, Fucharoen S, Svasti S.Cardiomyocyte ultrastructural damage in β-thalassaemic mice.int J Exp Pathol Oct;94(5): doi: /iep Chuansumrit A, Anantasit N, Sasanakul W, Chaiyaratana W, Tangnararatchakit K, Butthep P, Chunhakan S, Yoksan S.Tumour necrosis factor gene polymorphism in dengue infection: association with risk of bleeding.paediatr Int Child Health. 2013;33(2): doi: / Y Butthep P, Chunhakan S, Yoksan S, Tangnararatchakij K, Chuansumrit A. Alteration of cytokines and chemokines during febrile episodes associated with endothelial cell damage and plasma leakage in Dengue Hemorrhagic Fever. Pediatr Infect Dis J Aug 24 [Epub ahead of print] 4. Kengkate M, Butthep P, Kupatawintu P, Kanunthong S, Chantratita W, Nathalang O, Genotyping of HPA-1 to -7 and -15 in the Thai population using multiplex PCR. Transfus Med Aug; 22(4): Sroymora S, Jindadamrongwech S, Butthep P, Chuncharunee S. Nondeletional Hb Queens Park [α32(b13)met Lys]/Hb H (β4) Disease. Hemoglobin ;36(3): Sroymora S, Jindadamrongwech S, Butthep P, Chuncharunee S. A Rare Hb H Disease Due to the - -(SEA) and 16.6 kb α-thalassemia-2 Deletions. Hemoglobin Feb 29. [Epub ahead of print] 7. Pakakasama S, Surayuthpreecha K, Pandee U, Anurathapan U, Maleewan V, Udomsubpayakul U, Butthep P, Santanirand P, Sirachainan N, Hongeng S. Clinical practice guidelines for children with cancer presenting with fever to the emergency room. Pediatr Int Dec;53(6): Munkongdee T, Pichanun D, Butthep P, Klamchuen S, Chalermpolprapa V, Winichagoon P, Svasti S, Fucharoen S. Quantitative analysis of Hb Bart s in cord blood by capillary electrophoresis system. Ann Hematol Jul; 90(7):

3 Banyatsuppasin W, Butthep P, Atichartakarn V, Thakkinstian A, Archararit N, Pattanapanyasat K, Chuncharunee S. Activation of mononuclear phagocytes and its relationship to asplenia and phosphatidylserine exposing red blood cells in hemoglobin E/β-thalassemia patients. Am J Hematol Jan; 86(1): Pichanun D, Munkongdee T, Klamchuen S, Butthep P, Winichagoon P, Fucharoen S, Svasti S. Molecular Screening of the Hbs Constant Spring (codon 142, TAA>CAA, α2) and PAKSÉ (codon 142, TAA>TAT, α2) Mutations in Thailand. Hemoglobin. 2010;34(6): Chuansumrit A, Puripokai C, Butthep P, Wongtiraporn W, Sasanakul W, Tangnararatchakit K, Chunhakan S, Yoksan S. Laboratory predictors of dengue shock syndrome during the febrile stage. Southeast Asian J Trop Med Public Health 2010; 41(2): Jindadamrongwech S, Tungbuppha N, Chuncharunee S, Butthep P. Hb Tak and Hb Q-Thailand in Thai patients are S-window hemoglobin variants revealed by high performance liquid chromatography. Hemoglobin Jan;34(2): Chunhakan S, Butthep P, Yoksan S, Tangnararatchakit K, Chuansumrit A. Early diagnosis of dengue virus infection by detection of dengue viral antigen in peripheral blood mononuclear cell. Pediatr Infect Dis J Dec;28(12): Futrakul N, Butthep P, Futrakul P. Altered vascular homeostasis in type 2 diabetic nephropathy. Ren Fail 2009; 31(3): Futrakul N, Butthep P, Futrakul P. Altered vascular homeostasis in chronic kidney disease. Clin Hemorheol Microcirc 2008; 38(3): Futrakul N, Butthep P, Laohareungpanya N, Chaisuriya P, Ratanabanangkoon K. A defective angiogenesis in chronic kidney disease. Ren. Fail. 2008; 30: Futrakul N, Butthep P, Futrakul P, Sitprija V. Improvement of renal function in type 2 diabetic nephropathy. Ren. Fail. 2007; 29(2): Butthep P, Wanrum S, Pattanapanyasat K, Vattanaviboon P, Fucharoen S, and Wilairat P. Cytoadherence between endothelial cells and P. falciparum infected and noninfected normal and thalassemic red blood cells. Cytometry B Clin Cytom. 2006; 70 (6):

4 Butthep P, Chunhakan S, Tannararachakij K, Yoksan S, Pattanapanyasat K, Chuansumrit A. Elevated soluble thrombomodulin in the febrile stage is related to patients at risk for dengue shock syndrome. Pediatr Infect Dis J. 2006; 25 (10): Futrakul N, Butthep P, Vongthavarawat V, Futrakul P, Sirisalipoch S, Chaivatanarat T, Suwanwalaikorn S. Early detection of endothelial injury and dysfunction in conjunction with correction of hemodynamic maladjustment can effectively restore renal function in type 2 diabetic nephropathy. Clin Hemorheol Microcirc. 2006; 34 (3): Futrakul N, Butthep P, Chunhakarn S, Banyatsappasin W, Futrakul P, Sitprija V. A deficient VEGF enhances endothelial cell loss and impaired renal function. Ren. Fail. 2006; 28(5): Futrakul N, Butthep P., Futrakul P., Sittipreja V. Glomerular endothelial dysfunction in type 2 diabetes mellitus. Ren Fail. 2006; 28 (6): Futrakul N, Butthep P, Patumraj S, Siriviriyakul P, Futrakul P. Microvascular disease and endothelial dysfunction in chronic kidney diseases: Therapeutic implication. Clin Hemorheol Microcirc 2006; 34(1-2) Butthep P, Wanrum S, Pattanapanyasat K, Vattanaviboon P, Fucharoen S, and Wilairat P. Cytoadherence between endothelial cells and P. falciparum infected and noninfected normal and thalassemic red blood cells. The 6 th Awaji International Forum on Infection and Immunity. 4-7 September 2006, Hyogo, Japan. 25. Butthep P, Chunhakan S, Tannararachakij K, Yoksan S, Pattanapanyasat K, Chuansumrit A. An elevated level of soluble thrombomodulin in the febrile stage is related to patients at risk for dengue shock syndrome. The 2 nd Asian Regional Dengue Research Network Meeting September 2005, Singapore. 26. Futrakul N, Butthep P. Early detection of endothelial dysfunction and early therapeutic correction effectively restore renal function in type 2 diabetic nephropathy. Ren Fail. 2005; 27 (4): Futrakul N, Butthep P, Futrakul P. Biomarkers of endothelial injury in focal segmental glomerulosclertic nephrosis. Ren Fail. 2005; 27 (4):

5 Futrakul P, Butthep P, Patumraj S, Futrakul N. Microvascular disease and endothelial dysfunction in chronic kidney diseases: Therapeutic implication. The 30 th annual meeting of Japanese Society for Microcirculation (JSM 05) February 23-24, Tokyo, Japan. 29. Butthep P, Chunhakan S, Tannararachakij K, Pattanapanyasat K, Yoksan S, Chuansumrit A, Possible evidence of endothalial cell dysfunction in dengue heorrhagic fever. The 10 th International Society of Hematology-Asia Pacific Division 2004, Nagoya, Japan. 1-4 September P Futrakul N, Panichkul T, Butthep P, Futrakul P, Jetanalin P, Patumraj S, Siriviriyakul P. Ganoderma lucidum suppresses endothelial cell cytotoxicity and proteinuria in persistent proteinuric focal segmental glomerulosclerosis (FSGS) nephrosis. Clin Hemorheol Microcir 31(4): , Butthep P, Nuchprayul I, Futrakul N. Endothelial injury and altered hemodynamics in thalassemia. Clin Hemorheol Microcirc 31(4): , Futrakul N, Siriviriyakul P, Panichakul T, Butthep P, Patumraj S, Futrakul P. Glomerular endothelial cytotoxicity and dysfunction in nephrosis with focal segmental glomerulosclerosis. Clin Hemorheol Microcirc 29 : ; Bunyaratvej A, Wisedpanichkij R, Jindadamrongwech S, Sila-asna M, Butthep P, Shirakami A, Wada K, Fujimoto K, Puntumetakul M, Sanyanusin P, Sithithaworn J, Kemtonglang N, Kuaha K, Mundee Y, Chanarat P, Nopparatana C, Rungjeadpha J, Buathong S, Thassanaleelaporn U, Kongkan C. Gold standard multi-center in Thailand. Advanced Technology in Laboratory Medicine. The 5 th Colloquium of Asian Network for Clinical Laboratory Standardization and Harmonization (ANCLS). December 2003, p Butthep P, Rummavas S, Jindadamrongwech S, Wisedpanichkij R, and Bunyaratvej A: Increased circulating activated endothelial cells, vascular endothelial growth factor and tumor necrosis factor in thalassemia. Am J of Hematology 2002 ; 70 : Futrakul N, Butthep P, Patumraj S, Tipprukmas N and Futrakul P. Enhanced tumor necrosis factor in the serum and renal hypoperfusion in nephrosis associated with focal segmental glomerulosclerosis. Renal Failure 2000; 22 (2),

6 Futrakul N, Butthep P, Patumraj S, Futrakul P. Glomerular endothelial dysfunction and altered cytokines in severe nephrosis. Nephron 2000; 86: Butthep P, Wisedpanichkij R, Jindadamrongwech S, Kaewkethong P, Pattamakom S, Sila-Asna M, Bunyaratvej A. Reticulocyte analysis in iron deficiency anemia and hemolytic anemia. J Med Assoc Thai 2000; 83 (Suppl. 1) : S114 S Butthep P, Jindadamrongwech S, Kaewkethong P, Panyayutho B, Wisedpanichkij R, Bunyaratvej A : Reticulocyte analysis in systemic lupus erythematosus and chronic renal failure using flow cytometry. Asian Pacific J of Allergy and Immunology 2000; 18 : Bunyaratvej A, Jindadamrongwech S, Sila-Asna M, Wisedpanichkij R, Butthep P, Munsawad S, Shirakami A, Fujimoto K : External Quality Assessment of Hematology Laboratories in Thailand. Sysmex J Int 1999; 9(2): Wisedpanichkij R, Jindadamrongwech S, Sila-Asns M, Butthep P and Bunyaratvej A. Precaution of Hb Constant Spring identification : A suggestive mean for the use of laboratory investigation. Abstract book of the IX Congress of ISH. Asian Pacific Division, October 1999, Thailand. Allergy and Immunology 1999; 17 (Suppl 1) : Jindadamrongwech S, Wisedpanichkij R, Sila-Asna M, Butthep P and Bunyaratvej A. Decreased Hemoglobin E levels are Suggestive for Alpha Gene interaction in Thai population. Abstract book of the IX Congress of ISH. Asian Pacific Division, October 1999, Thailand. Allergy and Immunology 1999; 17 (Suppl 1) : Kaewkathong P, Butthep P, and Bunyaratvej A. Increased CD4/ CD8 ratio in Aids patients with eosinophilia. Abstract book of the IX Congress of ISH. Asian Pacific Division, October 1999, Thailand. Allergy and Immunology 1999; 17 (Suppl 1) : Butthep P, Jindadamrongwech S, Kaewkathong P, Youngpung C, Wisedpanichkij R and Bunyaratvej A. Reticulocyte analysis in systemic lupus erythematosus and chronic renal failure using flow cytometry. Abstract book of the IX Congress of ISH. Asian Pacific Division, October 1999, Thailand. Allergy and Immunology 1999; 17 (Suppl 1) : 46.

7 Bunyaratvej A, Butthep P, Sae-Ung N, Fucharoen S, Kitaguchi H, Funahara Y. Role of thalassemic erythrocytes and endothelial cells in hemorrheology. Abstract book of The Third Asian Congress for Microcirculation. Bangkok, Thailand October 20-22, Opartkiatikul N, Funahara Y, Sukpanichnant S, Wanachiwanawin W, Fucharoen S, Sumiyoshi A, Sangtawesin W, Thientadakul P, Kitaguchi H, Hijikata- Okunomiya A, Butthep P, Bunyaratvej A : The effect of Dilazep in - thalassemia/ hemoglobin E patients. Proceedings: The Third Asian Congress for Microcirculation. Bunnag S.C.m. Srikiatkhamchorn A, Patumraj S (eds), Monduzzi Editore S.p.A. Bologna, Italy 1997; pp Butthep P, Khuhapinant A, Bunyaratvej A, Funahara Y, Kitaguchi H, Fucharoen S : Thalassemia serum inhibit endothelial cell mitosis in vitro. Southeast Asian J Trop Med Public Health 1997; 28 (Suppl 3): Sangtaweesin W, Hijikata-Okunomiya A, Opartkiattikul N, Wongtiraporn W, Luenee P, Butthep P, Kitaguchi H, Fucharoen S, Funahara Y : Surface and total tissue factor activity of endothelial cells. Southeast Asian J Trop Med Public Health 1997; 28 (Suppl 3): Bunyaratvej A, Butthep P, Yoksan S, Bhamarapravati N : Dengue viruses induce cell proliferation and morphological changes of endothelial cells. Southeast Asian J Trop Med Public Health 1997; 28 (Suppl 3): Bunyaratvej A, Butthep P, Kaewkettong P, Yuthavong Y : Malaria protection in hereditary ovalocytosis : Relation to red cell deformability, red cell parameters and degree of ovalocytosis. Southeast Asian J Trop Med Public Health 1997; 28 (Suppl 3): Butthep P, Bunyaratvej A, Funahara Y, Kitaguchi H, Fucharoen S, Sato S, Bhamarapravati N : The possible evidence of endothelial cell activation in Thalassemia : An in vitro study. Southeast Asian J Trop Med Public Health 1997; 28 (Suppl 3): A. 51. Sangtaweesin W, Hijikata-Okunomiya A, Opartkiattikul N, Wongtiraporn W, Luenee P, Butthep P, Kitaguchi H, Fucharoen S, Funahara Y : A sensitive method to study tissue factor expression of endothelial cell. Abstract book of PSU-ICMR Symposium July 1996.

8 Bunyaratvej A, Butthep P, Yoksan S, Bhamarapravati N : Dengue viruses induce cell proliferation and morphological changes of endothelial cells. Abstract book of PSU-ICMR Symposium July Bunyaratvej A, Butthep P, Kaewkettong P, Yuthavong Y : Impaired growth and invasion of Plasmodium falciparum in erythrocytes from individuals with hereditary ovalocytosis : A comparative study between patients and their parents. Abstract book of PSU-ICMR Symposium July Butthep P, Bunyaratvej A, Funahara Y, Kitaguchi H, Fucharoen S, Sato S, Bhamarapravati N : Exploration on endothelial cell activation under in vitro thalassemic conditions. Abstract book of PSU-ICMR Symposium July Bunyaratvej A, Khuhapinant A, Butthep P, Jindadamrongwech S, Fucharoen S: Reticulocyte analysis in hemoglobin H and hemoglobin constant spring. Congress Asian Pacific Division International Society of Hematology October 15-18, Brisbane, Bunyaratvej A, Butthep P, Khuhapinant A, Jindadamrongwech S, Fucharoen S: Red cell and reticulocyte analysis in thalassemia and other related disease : An approach to erythropoietic study and diagnosis. Australial Institute of Medical Scientist October 9-13, Gold Coast, Butthep P, Bunyaratvej A, Funahara Y, Kitaguchi H, Fucharoen S, Sato S, Bhamarapravati N : Alteration in vascular endothelial cell-related plasma proteins in thalassemic patients and their correlation with clinical symptoms. Thromb Haemost 1995; 74(4): Bunyaratvej A, Fucharoen S, Butthep P, Sae-Ung N, Kamchonwongpaisan S, Khuhapinant A: Alteration and pathology of thalassemic red cells: comparison between alpha- and beta- types. Southeast Asian J Trop Med Public Health 1995; 26 (Suppl 1): Butthep P, Bunyaratvej A, Bhamarapravati N: Dengue virus and endothelial cell: A related phenomenon to thrombocytopenia and granulocytopenia in dengue hemorrhagic fever. Southeast Asian J Trop Med Public Health 1993; 24 (Suppl 1):

9 Bunyaratvej A, Butthep P, Bunyaratvej P: Cytometric analysis of blood cells from malaria-infected patients and in vitro infected blood. Cytometry 1993; 14: Butthep P, Bunyaratvej A : An unusual adhesion between red cells and platelets in falciparum malaria. J Med Assoc Thai 1992; 75 (Suppl 1): Bunyaratvej A, Butthep P : Cytometric analysis of paroxysmal nocturnal hemoglobinuria erythrocytes. J Med Assoc Thai 1992; 75 (Suppl 1): Kitaguchi H, Funahara Y, Butthep P, Bunyaratvej A: Red blood cells and platelets induced differentiation of endothelial cells into capillary-like structures. Southeast Asian J Trop Med Public Health 1992; 23 (Suppl 2): Bunyaratvej A, Butthep P, Fucharoen S, Saw D: Erythrocyte volume and hemoglobin concentration in hemoglobin H disease: Discrimination between the two genotypes. Acta Haematol 1992; 87: Bunyaratvej A, Funahara Y, Butthep P, Kitaguchi H, Fucharoen S: Thalassemic serum impairs endothelial cell growth in vitro. Southeast Asian J Trop Med Public Health 1992; 23 (Suppl 2): Butthep P, Bunyaratvej A, Kitaguchi H, Funahara Y, Fucharoen S: Interaction between endothelial cells and thalassemic red cells in vitro. Southeast Asian J Trop Med Public Health 1992; 23 (Suppl 2): Bunyaratvej A, Butthep P, Sae-Ung N, Fucharoen S, Yuthavong Y: Reduced deformability of thalassemic erythrocytes and erythrocytes with abnormal hemoglobins and relation with susceptibility to Plasmodium falciparum invasion. Blood 1992; 79: Bunyaratvej A, Butthep P, Yoksan S, Bhamarapravati N: In vitro interaction between endothelial cells and dengue virus. Southeast Asian J Trop Med Public Health 1990; 21(4): Yuthavong Y, Butthep P, Bunyaratvej A, Fucharoen S : Decreased sensitivity to artesunate and chloroquine of Plasmodium falciparum infection Hemoglobin H and/ or Hemoglobin Constant Spring erythrocytes. J Clin Invest 1989; 83: Bunyaratvej A, Fucharoen S, Butthep P,Saw D : Flow cytometric analysis of thalassemia carrier states. Am J Clin Patho 1989; 92: 548.

10 Bunyaratvej A, Fucharoen S, Hathirat P, Saw D, Butthep P: Discrimination between the two genotypes of Hemoglobin H disease using the H*1 system. Am J Clin Patho 1989; 92: Yuthavong Y, Butthep P, Bunyaratvej A, Fucharoen S, Khusmith S: Impaired parasite growth and increased susceptibility to phagocytosis of Plasmodium falciparum infected alpha-thalassemia or Hemoglobin Constant Spring red blood cells. Am J Clin Patho 1988; 89: Yuthavong Y, Butthep P, Bunyaratvej A, Fucharoen S : Inhibitory effect of -thalassemia/ haemoglobin E erythrocytes on Plasmodium falciparum growth in vitro. Tran Roy Soc Trop Hyg 1987; 81: Bunyaratvej A, Butthep P, Yuthavong Y, Fucharoen S, Khusmith S, Yoksan S, Wasi P : Increased phagocytosis of P. falciparum infected erythrocytes with Haemoglobin E by peripheral blood monocyte. Acta Haematol 1986; 76: National publication : 1. Chunhakan S, Butthep P, Tungnararachakij K, Pattanapanyasat K, Yoksan S, Chuansumrit A. Elevataed level of soluble thrombomodulin in patients at risk for dengue shock syndrome. Abstract book of The Association of Medical Technologists of Thailand, 29 April-2 May 2005: no. M15: Wanrum S, Butthep P, Fucharoen S, Pattanapanyasat K, Vattanaviboon P, Wilairat P. Comparative Study of The Adhesion of Plasmodium Falciparum Infected Normal and Thalassemic Red blood cells to Cultured Endothelium Abstract book of The Association of Medical Technologists of Thailand, 29 April-2 May 2003: no. M9: p , Butthep P, Wanrum S, Fucharoen S, Pattanapanyasat K, Vattanaviboon P, Wilairat P. Comparative Study of The Adhesion of Plasmodium Falciparum Infected Normal and Thalassemic Red blood cells to Cultured Endothelium Abstract book of Ramathibodi Conference 1-3 May Ramathibodi Hospital, Bangkok; Thailand: no. 63, 2003.

11 Butthep P, Jindadamrongwech S, Wisedpanichkij R, Kaewkethong P, Bunyaratvej A. Interactive role of circulating endothelial cells and pathogenesis of vascular complications in thalassemic patients. Abstract book of The Thailand Research Fund (TRF-PDF) January 28-30, Thailand. pp , Bunyaratvej A, Khuhapinant A, Butthep P, Jindadamrongwech S, Suwiwat S, Sae-Ung N, Fucharoen S, Pattanapanyasat K, Sahaphong S : Mechanism of red cell destruction and ineffective erythropoiesis in thalassemic patients : The causes of anemia and severity of the disease. Abstract book of the 24 th Congress on Science and Technology of Thailand. October 19-21, Bangkok, Thailand, Khuhapinant A, Bunyaratvej A, Butthep P, Jindadamrongwech S, Fucharoen S. The discrepancy in hydration state of hemoglobin constant spring- containing erythrocytes occurs as early as during their reticulocyte stage. Abstract book of Third annual conference on the prevention and control of thalassemia 1.6, Butthep P, Bunyaratvej A. Susceptibility of thalassemic hemoglobinopathic erythrocytes to phagocytosis by monocytes in vitro. Abstract book of Twentieth Anniversary Ramathibodi Conference 185, Butthep P. T cell functions in infants and children with beta-thalassemia. J Med Tech Assoc Thailand 16 (2) : 139, 1988.