Ambulatory Monitoring of Pulmonary Artery Pressure: Why and How 18 th Annual San Diego Heart Failure Symposium
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1 Ambulatory Monitoring of Pulmonary Artery Pressure: Why and How 18 th Annual San Diego Heart Failure Symposium Primary Care and Internal Medicine Physicians January 19-20, 2018 Howie Tran MD, FACC Assistant Professor of Medicine University of California, San Diego Advanced Heart Failure, Cardiac Transplantation & Mechanical Circulatory Support
2 Presenter Disclosure Information I will discuss off-label use of medications and/or devices during this discussion. I do not have financial relationships with industry related to this presentation.
3 Overview of the Talk Discussion of the Burden of Heart Failure and Readmissions Prior Attempts of Remote Monitoring Ambulatory Pulmonary Artery Pressure Monitoring (CardioMEMS TM ): Champion Trial The application of CardioMEMS TM in practice The future of remote HF monitoring
4 Heart Failure prevalence in the US is projected to increase 46% by Patients with HF will rise to 8M in 2030, one in every 33 people.
5 Economic Burden of Heart Failure will continue to rise through 2030 The AHA estimates that the total medical costs for HF are projected to increase to $70B by 2030 a 2-fold increase from % of costs related to hospitalization
6 HF-related Hospitalizations are strong Predictors of Mortality Each admission decreases a patient s chance of survival
7 Current HF Management How well do current tools keep patients stable and out of the hospital? 90% of HF hospitalizations due to symptoms of pulmonary congestion 1,2 40% moderate to severe AT DISCHARGE Post-hoc analysis of 463 acute decompensated HF patients from DOSE-HF and CARRESS-HF 60% absent or mild congestion 3 congestion 3 AT 60-DAY FOLLOW-UP TODAY S TOOLS ARE INADEQUATE at relieving congestion (inpatient) and preventing re-congestion and readmission (outpatient) even at well-established HF management programs and with the best HFtrained specialists. 1. Adams KF, et al. Am Heart J Krum H and Abraham WT. Lancet Lala A, et al. JCF % of previously decongested patients had severe or partial re-congestion 3 7
8 How problematic are readmissions? ZDoggMD
9 Vicious Cycle of Congestion in HF Desai et al. Am J Cardiol 2015; vol. 116 open-access Web publication
10 The Iceberg Analogy Photo by National Geographic
11 Current HF Management How do current parameters impact HF hospitalization? Trial N Parameter Monitored/ Clinician Interaction Impact on HF Hospitalization Reference TELE-HF 1 1,653 Signs/symptoms, daily weights None Chaudhry SI et al. N Engl J Med, 2010 TIM-HF Signs/symptoms, daily weights None Koehler F et al. Circulation, 2011 TEN-HMS BEAT-HF 4 1,437 INH Signs/symptoms, daily weights, BP, nurse telephone support Signs/symptoms, daily weights, nurse communications Signs/symptoms, telemonitoring, nurse coordinated DM None Cleland JG et al. JACC, 2005 None None DOT-HF Intrathoracic impedance with patient alert Increased Ong MK et al. AHA 2015 LBCT Angermann DE et al. Circ Heart Fail, 2012 Van Veldhuisen DJ et al. Circulation, 2011 Optilink 7 1,002 Intrathoracic impedance None Bohm M et al. Eur J HF, 2011 REM-HF 8 1,650 Remote monitoring via ICD, CRT-D, or CRT-P None CowieMR et al. ESC 2016 MORE CARE Total 8,793 Remote monitoring of advanced diagnostics via CRT-D None Boriani G et al. Eur J HF, 2016 Multiple trials studying >8500 patients have demonstrated that current markers have NO IMPROVEMENT ON HF HOSPITALIZATION
12 Current HF Management: Why aren t current parameters working? Graph adapted from Adamson PB, et al. Curr Heart Fail Reports, 2009.
13 Current HF Management: How can we get ahead of symptoms associated with acute decompensation? Graph adapted from Adamson PB, et al. Curr Heart Fail Reports, 2009.
14 Intracardiac Pressures:
15 CardioMEMS TM : PA Sensor Technology Sensor = hermetically sealed capsule containing a inductor coil and pressuresensitive capacitor Anchor = Nitinol wire loops extend to stabilize the sensor in the implant location Change in blood pressure affects resonant frequency Tracked by external measurement system pulmonary artery pressure MEMS PA Sensor Technology
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17 12 HF patients NYHA III/IV Wireless PAP measurements Oral warfarin continued throughout study Echocardiographic evaluation of TR flow velocity (VTR) to obtain the systolic pulmonary artery pressure Swan Gantz (SG) catheter measurements used as reference for calibration Echo-Doppler PAP measurements at 2, 14, 30, 60, and 90 days SG measurements were repeated at day 60
18 CardioMEMS TM Correlation: Does drift happen? Correlation was observed for the Pa sys measurement between HFS and SG (r 2 = 0.90 at the initial implant and r 2 = 0.94 at follow up, p < 0.01)
19 Prospective, multicenter Randomized single-blinded trial 550 patients 64 sites in the US October 2009 until March 2010 NYHA functional Class III HF (h/o HF > 3 mos) Standard-of-care HF management CardioMEMs Follow up: month 1, 3, 6, then every 6 months thereafter, up to 36 months
20 Transmitted information Pressure trend information Target hemodynamic monitoring pressure values PA sys pressure mmhg PA dia pressure 8-20 mmhg PA mean pressure mmhg
21 Cumulative Heart Failure-related Hospitalization
22 Freedom from first Heart Failure-related hospitalization or mortality
23 Weekly Report: from St Jude Medical/Abbott
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27 Downloaded from by guest on January 21, 2017 Novel devices Telemonitoring in chronic heart failure Ayesha Hasan 1 * and Vince Paul 2 1 Division of Cardiovascular Medicine, Heart Failure Devices Clinic, Ohio State University Medical Center, Columbus, OH 43210, USA; and 2 Royal Perth Hospital, Wellington Street Campus, Perth, WA 6001, Australia Received 22 July 2010; revised 3 January 2011; accepted 11 January 2011 Clinical management of refractory heart failure remains challenging, with a high rate of rehospitalizations despite advances in medical and device therapy. Care can be provided in person, via telehomecare (by telephone), or telemonitoring, which involves wireless technology for remote follow-up. Telemonitoring wirelessly transmits parameters such as weight, heart rate, or blood pressure for review by health-care professionals. Cardiac implantable devices (defibrillators and cardiac resynchronization therapy) also transmit continually interrogated physiological data, such as heart rate variability or intrathoracic impedance, which may be of value to predict patients at greater risk of hospitalization for heart failure. The use of remote monitoring techniques facilitates a rapid and regular review of such data by health-care workers as part of a heart failure management programme. Current evidence supports the feasibility of such an approach but routinely assessed parameters have been shown not to impact patient outcomes. Devices that directly assess cardiac haemodynamic status through invasive measurement of pressures are currently under investigation and could potentially increase the sensitivity and specificity of predicting heart failure events. The current evidence for telemonitoring and remote monitoring, including implantable haemodynamic devices, will be reviewed K eyw or ds Intrathoracic impedance Telehomecare Telemonitoring Haemodynamic monitoring Intracardiac pressures Introduction Despite advances in pharmacological and device therapy for chronic heart failure management, progression of heart failure remains a health-care burden. Clinical management to prevent Results of studies have been contradictory, with many of the studies being small or having variable endpoints. However, meta-analyses have suggested that telemonitoring and telephone support may provide better clinical outcomes than usual care, with a reduction in mortality and hospital admissions 1,2 3
28 CHAMPION Trial results: Number Needed to Treat to Prevent One HF-related hospitalization PART 1: RANDOMIZED ACESS PART 2: OPEN ACCESS Intervention Trial Mean Duration of Randomized Follow-Up NNT/Year to Prevent 1 HF Hospitalization Beta-blocker 1 COPERNICUS 10 months 7 Aldosterone antagonist 2 RALES 24 months 7 CRT 3 CARE-HF 29 months 7 Beta-blocker 4 MERIT-HF 12 months 15 ACE inhibitor 5 SOLVD 41 months 15 Aldosterone antagonist 6 EMPHASIS-HF 21 months 16 Digoxin 7 DIG 37 months 17 Angiotensin receptor blocker 8 Val-HeFT 23 months 18 Angiotensin receptor blocker 9 CHARM 40 months 19 PA pressure monitoring 10 CHAMPION 18 months < 4 1. Packer M, et al. Circulation Pitt B, et al. N Engl J Med Cleland JG, et al. N Engl J Med Hjalmarson A, et al. JAMA The SOLVD Investigators. N Engl J Med Zannad F, et al. N Engl J Med Digitalis Investigation Group. N Engl J Med Cohn JN, et al. N Engl J Med Young JB, et al. Circulation Adamson, P. et al. HFSA PA PRESSURE MONITORING LED TO LOWER NNT to prevent one HF-related hospitalization vs. other therapies.
29 Current HFpEF Management What are the current recommendations?
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31 IMPLEMENTING a CardioMEMS Best practices for managing a CardioMEMs TM KEYS TO SUCCESS 1 PATIENT SELECTION Identifying patients most likely to benefit from CardioMEMS HF System is critical. Some patients are too sick (NYHA IV); some patients are too well (NYHA I-II). 2 PATIENT FLOW Patient compliance and HF team workflow revision are important to ensure appropriate interpretation and management of individual patients. 3 SERVICE MANAGEMENT Scaling the service requires process and workflow considerations.
32 Heart Failure is Complex & Subjective to Diagnose Heart Failure treatment is frequently reactive, and many patients are hospitalized because the warning signs are not recognized in time. Typical tests and in-office questions that providers may ask the patient Listen to the heart for signs of elevated S3 heart sounds Listen to the heart for signs of depressed cardiac contractility Listen to lung sounds for signs of pulmonary edema Measure blood pressure Measure if resting heart rate is elevated Ask How many pillows do you sleep on at night? Ask Are you out of breath? Have difficulty breathing? Ask Have you been feeling tired? Ask Have you gained weight? Boston Scientific Corporation or its affiliates. All rights reserved. CRM AE OCT2017
33 Introducing HeartLogic TM Heart Failure Diagnostic HeartLogic shifts heart failure patient management from reactive treatment to proactive care, and was validated in the MultiSENSE Study to have: High sensitivity of 70% for detecting heart failure events Weeks of advance notice of a potential heart failure event Low burden of less than 2 alerts per patient per year HeartLogic incorporates multiple sensors with a single composite alert Heart Sounds S1 & S3 Impedance Thoracic Respiration Rate & Volume Activity Time Spent Active Heart Rate Night Available on LATITUDE NXT for patients with Resonate family of ICDs & CRT-Ds multiple sensor measurements combined into a single, simple index with alert Boehmer, J et al., JACC-HF, 2017;5(3), Boston Scientific Corporation or its affiliates. All rights reserved. CRM AE OCT2017
34 HeartLogic Heart Failure Management Report A comprehensive report via LATITUDE NXT details HeartLogic and a diverse set of heart failure sensors. (a) HeartLogic Alert Notification (b) HeartLogic Composite Index a b e (c) HeartLogic Configurable Threshold d c (d) HeartLogic Contributing Trends (e) HeartLogic Detailed Trend Data e MultiSENSE Study Report is for educational example and purposes only Boston Scientific Corporation or its affiliates. All rights reserved. CRM AE OCT2017
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36 Conclusions: 1. The clinical and economic burden of HF in America continues to be on the rise 2. The CardioMEMS TM device MAY be a resource to guide therapy (to reduced readmissions for congestion) 3. Patient selection is crucial for remote hemodynamic monitoring
37 The Iceberg Analogy Photo by National Geographic
38 Just don t leave your patients hanging Photo by Carla Lombardo Ehrlich (World Wildlife Foundation)
39 Any other options? ZDoggMD
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